CN117940771A - 用于评估候选药剂的治疗性质的方法和模型系统以及相关的计算机可读介质和系统 - Google Patents

用于评估候选药剂的治疗性质的方法和模型系统以及相关的计算机可读介质和系统 Download PDF

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CN117940771A
CN117940771A CN202280061668.XA CN202280061668A CN117940771A CN 117940771 A CN117940771 A CN 117940771A CN 202280061668 A CN202280061668 A CN 202280061668A CN 117940771 A CN117940771 A CN 117940771A
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cell
cells
balanced
cell types
culture
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H·古达兹
约翰尼·余
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
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    • C12N2510/00—Genetically modified cells
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    • C12N2513/00—3D culture

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  • Evolutionary Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Computing Systems (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202280061668.XA 2021-07-23 2022-07-22 用于评估候选药剂的治疗性质的方法和模型系统以及相关的计算机可读介质和系统 Pending CN117940771A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163225209P 2021-07-23 2021-07-23
US63/225,209 2021-07-23
PCT/US2022/038069 WO2023004149A1 (en) 2021-07-23 2022-07-22 Methods and model systems for assessing therapeutic properties of candidate agents and related computer readable media and systems

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CN117940771A true CN117940771A (zh) 2024-04-26

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US (1) US20250003953A1 (https=)
EP (1) EP4374169A4 (https=)
JP (1) JP2024529939A (https=)
CN (1) CN117940771A (https=)
WO (1) WO2023004149A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118692590B (zh) * 2024-07-23 2024-12-27 浙江大学 基于单细胞转录组图谱的药物筛选分析方法、介质及设备

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518035B1 (en) * 1998-06-02 2003-02-11 Rosetta Inpharmatics, Inc. Targeted methods of drug screening using co-culture methods
WO2015182159A1 (ja) * 2014-05-30 2015-12-03 株式会社クラレ 培養方法及び細胞塊
US20190114390A1 (en) * 2017-10-13 2019-04-18 BioAge Labs, Inc. Drug repurposing based on deep embeddings of gene expression profiles
WO2021046027A1 (en) * 2019-09-02 2021-03-11 The Broad Institute, Inc. Rapid prediction of drug responsiveness
US20220404340A1 (en) * 2019-10-25 2022-12-22 Massachusetts Institute Of Technology Methods and compositions for high-throughput compressed screening for therapeutics

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US20250003953A1 (en) 2025-01-02
JP2024529939A (ja) 2024-08-14
WO2023004149A1 (en) 2023-01-26
EP4374169A4 (en) 2025-06-11
EP4374169A1 (en) 2024-05-29

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