CN1179094A - Coolant compositions - Google Patents
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- CN1179094A CN1179094A CN 96192630 CN96192630A CN1179094A CN 1179094 A CN1179094 A CN 1179094A CN 96192630 CN96192630 CN 96192630 CN 96192630 A CN96192630 A CN 96192630A CN 1179094 A CN1179094 A CN 1179094A
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Abstract
The present invention relates to compositions comprising a suitable carrier and a coolant combination of a glycol and a coolant and wherein the pH of said compositions is greater than about 8.2 in the composition itself or when used.
Description
Background of invention
The all kinds compositions is arranged, wherein added the component that refrigerant sensation can be provided mucosa and/or skin.Such compositions comprises toothpaste, collutory, perfume, lotion, the glue that shaves, back articles for use, shampoo, anti-perspirant, deodorizer, beverage, chewing gum, tobacco product and medicine etc. shave.
" refrigerant " effect of confirming alcohol already is the physiological effect that the direct effect of the hot or cold teleneuron of human body sensory is produced owing to it, rather than because the latent heat of evaporation.The effect that it is believed that alcohol is directly to stimulate the cold receptor of feeling that is positioned at teleneuron, and these receptors then stimulate the central nervous system again.
Can be used as physiological freshener although confirmed alcohol, because its intensive mint smell and relative volatility, its independent use is restricted in some compositions.
In technical literature, once reported some other chemical compound, and had the abnormal smells from the patient or the taste that are similar to alcohol, and usually be suggested in various externals and edible composition as flavoring agent or flavouring agent.For example, Japan Patent open 39-19627 has reported that the 3-hydroxymethyl has the abnormal smells from the patient of very similar 1- alcohol to alkane ( methanol), advises that it is used as the flavoring in confection, chewing gum and the Nicotiana tabacum L..In the Swiss Patent 484,032, some saccharide esters that propose alcohol can be used as the additive of Nicotiana tabacum L..French Patent (FRP) 1,572,332 have reported N, N-dimethyl 2-ethyl butyramide has mint smell and nice and cool effect, and with N, N-diethyl 2, the mint smell of 2-dimethyl propylene amide belongs to this type of.In Berichte 39,1223 (1906), reported N, the similar effect of N-diethyl 2-ethyl butyramide.At Parfums-Cosmetiques-Savons, in May, 1956, the 17-20 page or leaf has reported 2,4, and 6-trimethyl heptan-4-is pure and mild 2,4, the mint smell of 6-trimethyl hept-2-ene"-4-alcohol.Koryo, 95, among (1970) 39-43, studied and disclosed the refrigerant effect of pure and mild other relevant terpene alcohols of and derivant thereof.Also reported 2,3-to alkane glycol have intensive refrigerant taste (Beilstein, Handbuch der Organischen Chemie, 4th Ed. (1923) Vol.6, P.744).
Also disclose carboxylic acid amides and can be used for various compositionss.Two patents having described such material and compositions are United States Patent (USP)s 4,136,163 (on January 23rd, 1979, people such as Watson) and United States Patent (USP) 4,230,688 (on October 28th, 1980, people such as Rowsell).These patents and above-mentioned those all as a reference at this.
Provide the cooling properties of reinforcement although done significant effort to various products, but still improved performance need be provided, comprise more obvious refrigerant sensation.
Therefore, an object of the present invention is to provide the improved compositions that has adopted improved coolant compositions.
Also has a purpose to provide to comprise dihydroxylic alcohols and its pH improved coolant compositions greater than about 8.2 freshener.
Another object of the present invention provides the improved coolant compositions that comprises dihydroxylic alcohols, carboxylic acid amides and second kind of freshener.
To describe these and other purpose of the present invention below in detail.
Unless otherwise indicated, carry out all mensuration at 25 ℃, all percents are percetage by weight.
Summary of the invention
The invention provides the compositions that comprises a kind of suitable carriers, a kind of dihydroxylic alcohols and a kind of freshener, the pH value of described compositions is approximately greater than 8.2.Also comprise the method that refrigerant sensation is provided in scope of the present invention.
The detailed description of invention
Describe component of the present invention below in detail.
Dihydroxylic alcohols:
The term that uses in this description " dihydroxylic alcohols " refers to comprise any dihydroxylic alcohols that is applicable to the mucomembranous surface of skin, oral cavity or digestive tract etc.Suitable dihydroxylic alcohols comprises propylene glycol, butanediol, hexanediol and composition thereof.Wherein preferred dihydroxylic alcohols is a propylene glycol.
When being used alone or in combination the dihydroxylic alcohols material, its amount in compositions is about 0.1-10%, is about 1-8% preferably, preferably is about 2-6%.
Freshener:
The second kind of component that needs among the present invention is freshener.Freshener can be the various materials in the wide range.Carboxylic acid amides is wherein arranged.
It is at United States Patent (USP) 4,136 that discovery is best suited for carboxylic acid amides of the present invention, the carboxylic acid amides described in 163 (people such as Watson,, January, 23 days in 1979) and 4,230,688 (people such as Rowsell, on Augusts 28th, 1980).Two pieces of patents at this as a reference.
4,136, the carboxylic acid amides in 163 patents be N-replace-to alkane-3 carboxylic acid amides.These chemical compounds be the 3-of following formula replace-to alkane:
Wherein, when considering respectively, R ' is hydrogen or the aliphatic group that 25 carbon atoms are arranged at most; R " be hydroxyl or the aliphatic group that 25 carbon atoms are arranged at most, R when R ' is hydrogen " can also be the aromatic group that 10 carbon atoms are arranged at most, naphthyl, the pyridine radicals of benzene alkyl, naphthyl or the replacement of its optional phenyl, benzene alkyl or replacement that replaces certainly; When considering together with connected nitrogen-atoms, R ' and R " represent cyclic group or heterocyclic radical that 25 carbon atoms are arranged at most, as piperidino, morpholino etc.
In the superincumbent definition; " aliphatic series " is defined as comprising any straight chain, side chain or cyclic group or band aromatics unsaturated group, therefore comprises alkyl, cycloalkyl, alkenyl, cycloalkenyl group, alkynyl, hydroxy alkyl, acyloxy alkyl, alkoxyl, alkoxyalkyl, aminoalkyl, acylaminoalkyl, carboxyalkyl and similarly combination.
As R ' and R " be when aliphatic series, representational have methyl, ethyl, propyl group, butyl, isobutyl group, positive decyl, cyclopropyl, cyclohexyl, cyclopenta, suberyl methyl, 2-hydroxyethyl, 3-hydroxyl n-pro-pyl, 6-hydroxyl n-hexyl, 2-amino-ethyl, 2-acetoxyl group ethyl, 2-ethyl carboxy ethyl, 4-hydroxyl fourth-2-alkynyl, a carboxyl methyl etc.
As R " when being aryl, representational is benzyl, naphthyl, 4-methoxyphenyl, 4-hydroxy phenyl, 4-aminomethyl phenyl, 3-hydroxy-4-methyl phenyl, 4-fluorophenyl, 4-nitrobenzophenone, 2 hydroxy naphthalene base, pyridine radicals etc.
Patent 4,230, the carboxylic acid amides in 688 is acyclic uncle and secondary carboxylic acid amides.They have following structure
Wherein, when considering R ' and R respectively " time, R ' and R " respectively be hydrogen, C
1-C
5Alkyl or C
1-C
8Hydroxy alkyl, and total carbon number is no more than 8, when R ' is hydrogen, R " can also be the alkyl carboxyl alkyl that 6 carbon atoms are arranged at most;
When considering together, R ' and R " represent the alkylidene that 6 carbon atoms are arranged at most, the opposite end of this group is connected on the nitrogen-atoms of amide, forms azacyclo-, and its carbochain can be separated arbitrarily by oxygen;
R
1Be hydrogen or C
1-C
5Alkyl; R
2And R
3Respectively be C
1-C
5Alkyl; Condition is (i) R
1, R
2And R
3Total carbon atom number be at least 5, be preferably 5-10 carbon atom; (ii) work as R
1When being hydrogen, R
2Be C
2-C
5Alkyl, R
3Be C
1-C
5Alkyl, R
2And R
2At least one is a side chain, preferably is positioned at α or β position with respect to the carbon atom of structural formula acceptance of the bid * number.The freshener that adds comprises the material as ketal, the pure and mild glycol of .The ketal preferably that the present invention uses has following general formula
In the formula, R
1Representative has at least 1, but is no more than 3 hydroxyls, is preferably the C of 1 hydroxyl
1-C
6Alkylidene, R
2Or R
3Represent C separately respectively
1-C
10Alkyl, this alkyl can be arbitrarily be selected from hydroxyl, amino and halogen (as fluorine, chlorine, bromine or iodine), C by 1-3
5-C
7Cycloalkyl (better being cyclohexyl), C
6-C
12The group of aryl (better being phenyl) replace, condition is R
2And R
3The total number of carbon atoms be not less than 3, or R
2And R
3Represent an alkylidene together, this group with have a radicals R
2And R
3Carbon atom form 5-7 unit ring together, the basic body of this alkylidene also can be by C
1-C
6Alkyl replace.
Radicals R preferably
2And R
3Base comprises methyl, isopropyl and the tert-butyl group.
Radicals R
2And R
3The effect of effect length Compound I: short base causes effect immediately, the short time; Effect that postpone, long that long base then causes.To the cosmetics industry the very important point is the dissolubility of chemical compound in water; Especially to short radicals R
2And R
3Situation is like this really.
Basic preferably R
1Comprise 1,2-and 1, the 3-alkylidene, this base forms a dioxolanes Huo diox with two oxygen atoms and the carbon atom that is connected these two oxygen atoms.
Following formula is R wherein
2And R
3Those that represent an alkylidene together are Compound I preferably
In the formula, R
4-R
15Represent hydrogen or C separately respectively
1-C
6Alkyl, be preferably hydrogen or C
1-C
4Alkyl, m and n are respectively 0 or 1 separately.
The chemical compound preferably of formula Ia is those chemical compounds of 1 of ading up to of m+n, the i.e. ketal of any substituted Ketohexamethylene.
When having 1-3 substituent group, substituent group is methyl, isopropyl and the tert-butyl group preferably especially.
Can prepare ketal I by known method.For example, generally the acid catalyzed reaction by ketone can prepare ketal I, ketone be not less than normal C
3-C
6Aliphatic alcohol reaction, this aliphatic alcohol is not less than 3 but be not more than 5, is preferably 3 hydroxyl.General being used to prepares the ketone of ketal I and is not less than 0.5 molar equivalent, but is generally above this quantity 1.2-4 doubly, is preferably the 1.5-3 C that 3-5 hydroxyl arranged doubly
3-C
6Alcohol.The example of the acid catalyst that uses is p-methyl benzenesulfonic acid, phosphoric acid or the potassium acid sulfate (for example, every mole of ketone 0.1-3 gram p-methyl benzenesulfonic acid) of catalytically effective amount.Be preferably in to form in the organic solvent of azeotropic mixture with water and react, carry secretly, remove water that discharges when forming ketal or the auxiliary reagent that uses consume water, for example, use as ortho acid trialkyl ester by azeotropic.The example of preferred organic solvents has benzene,toluene,xylene, chloroform, dichloromethane and trichloroethane.
In the time no longer separating water outlet or no longer can separate ester output/alcohol mixture, can think to react completely.Diluted alkaline and water washing product are used in suggestion subsequently, separate and dry organic facies, remove and desolvate, if suitable, can adopt as distillatory method purification residue.Best ketal I is following those various chemical compounds
In the formula, R
1Have above-mentioned meaning, best among the ketal II-VI all is glycerol ketals.
The invention still further relates to ketal III-VI.The ketal I that uses in the compositions of the present invention can have asymmetric carbon atom; So optical isomerism can occur.According to employed raw material and preparation method, the mixture that they can optical isomer exists or exists with pure isomer.Therefore the cooling effect difference of each isomer needs to select one or another kind of isomer.
alcohol is the another kind of freshener that the present invention uses. alcohol is a component in the Oleum menthae, and it is widely used in oral care product, food additive and cosmetics.
The another kind of second suitable freshener is a glycol.Glycol is at United States Patent (USP) 4,459 preferably, those glycol that 425 people such as (, on July 10th, 1984) Amano propose, at this as a reference.A kind of glycol preferably is a 3-1-methoxy propyl-1, the 2-glycol.
In this compositions, can adopt the freshener chemical compound of any effective dose.General its amount in compositions is about 0.01-1%, better is about 0.05-0.60%, better is about 0.07-0.29%.
Carrier
Many compositionss of using above-mentioned coolant material are arranged, and can change.These compositionss comprise the various compositionss of consuming or be applied to human body for people.In a broad sense, these compositionss can be divided into edible-type compositions and topical composition, and these two terms are all considered from broad sense angle.Therefore, edible-type can be regarded as and not only comprise edible food additive and beverage, and comprises the compositions of the oral cavity absorption of not considering its nutritive value, as the tablet of taking in, antiacid preparation, laxative etc.Edible compositions also comprises can enter the oral cavity, but the edible composition that may not swallow, as chewing gum.Topical composition not only comprises the compositions that can be used for human body skin of medical or other purposes, as perfume, powder and other cosmetic product, lotion, liniment, oil and ointment, also comprise the inside mucosa that is used for human body, as nose, mouth or larynx or the compositions that when usually using, contacts with inner mucosa, and no matter it is directly or indirectly coating or suction, so they comprise spray, dentifrice, mouth-wash and the collutory compositions of nose and larynx.The present invention also comprises hygienic articles, as infiltration or be coated with the medicated napkin and the toothpick of effective cooling compounds.
Also comprising a based composition in the scope of the invention, is Nicotiana tabacum L. and the goods relevant with it, as the filter plug of the filter plug of tobacco pipe and medicated cigarette, particularly medicated cigarette.
When preparation compositions of the present invention, generally in a kind of carrier, add cooling composition, carrier can be complete inertia or contain other active component.Depend on the compositions final use, suitable carriers has a variety of, and such carrier comprises solid, liquid, emulsion, foams and gel.The typical carriers that is used for cooling composition has water or alcoholic solution; Oil ﹠ fat is as hydrocarbon-type oil, fatty acid ester, long-chain alcohol and silicone oil; The solid of pulverizing is as starch or Pulvis Talci; Cellulosic material is as paper; Nicotiana tabacum L.; Low boiling hydrocarbon and halogenated hydrocarbon as aerosol propellants; Gummy and natural or synthetic resin.
The following describes the scope that wherein can add the compositions of cooling composition:
1. the edible or the compositions of drinking comprise alcohol or non-alcohols beverage, confection, frosting, chewing gum; Jelly bean; Ice cream; Fruit jelly.
2. cosmetic product, comprise the detergent after shaving, the usefulness that shaves soap, snowization cream and foams, floral water, deodorizer and anti-perspirant, " solid cologne ", fancy soap, body lotion and salt, shampoo, scalp pomade, talcum powder, facial cream, hand cream, sunburn abluent, toilet paper, dentifrice, toothpick, dental floss (dental floss), toothbrush, mouth-wash, hair oil, dentures binding agent.
3. medicine comprises antibiotic ointment, liniment, lotion, Decongestant, counter-stimulus, cough mixture, lozenge, antacid and dyspepsia medicine, oral analgesic.
4. tobacco product comprises cigar, medicated cigarette, tobacco, quid and Folium Nicotianae preparatum; The filter plug of tobacco filter, particularly medicated cigarette.
5. various compositionss, as be used for envelope, stamp, adhesive label's etc. aqueous adhesive composition.
Below concrete goods of the present invention will be described in more detail.
Edible and the compositions of drinking:
Edible of the present invention and the compositions of drinking contain the cooling composition with edible carrier and common and flavoring agent or colorant combination.The special-effect of cooling compounds is in the oral cavity, cause refrigerant or feel cool under some situation in stomach, therefore, this compositions is in the confection of being made by sugar as chocolate, syrup, confection etc., in ice cream and the fruit jelly, and its special purposes is arranged in the chewing gum.The prescription of these confections is to obtain by common technology with according to common prescription, not as a part of the present invention.Usually, in final compositions, add coolant compositions at a convenient time, present in an amount at least sufficient in final product, produce required refrigerant sensation.As has been noted, can change its addition according to the intensity of refrigerant degree required in specific compositions, the compositions and other flavoring agent.
Similarly opinion may be used in the drink formula.Say that generally this compositions is applied at most in the soft drink as the carbonic acid of fruit, lemonade, cola etc. or non-carbonic acid, but also can be used in the alcoholic beverage.
Cosmetic product
Because can give and skin algefacient sensation, the main uses of cooling composition is to be used for various hygienic articles and cosmetic forehead product.Below concrete goods will be discussed for example.
A main uses is detergent after being used to shave and floral water etc., and wherein chemical compound will be used in ethanol or the aqueous alcoholic solution, and such solution generally also contains spice or deodorizer or two kinds to be had.
The Another application field is fancy soap, shampoo, body lotion etc., compositions wherein will be used in combination with fatty or a kind of natural or synthetic surfactant of a kind of oil such as soap or lauroyl sulfate, and compositions generally also contains a kind of essential oil or spice.The soap based composition comprises the soap of all kinds, as fancy soap, shaving soap, shaving foam glue etc.
Also have a class to add the make-up composition of coolant compositions, cosmetic cream and emollient are arranged, this frost and emollient generally comprise basic Emulsion and optional batching, as wax, antiseptic, spice, deodorizer, astringent, pigment etc.Be included in the lip composition that also has of this apoplexy due to endogenous wind, such compositions generally comprises a kind of oil or wax-matrix, and the batching that can add coolant compositions and routine therein is pigment, spice etc.Repeat once more, such composite formula is a versatile formulation.
The compositions that is used for oral hygiene that contains cooling composition comprises collutory and dentifrice composition, and they are preferred compositions.The first kind generally comprises a kind of water, ethanol or water-alcoholic solution of deodorizer, and deodorizer is usually painted or be the flavoring agent seasoning of 0.1-1.0 weight % with its amount.
Dentifrice composition can be powder, cream or liquid state, generally comprises a kind of abrasive or polishing material of pulverizing very carefully, as precipitated whiting, silicon dioxide, magnesium silicate, aluminium hydroxide or other similar material known in the art, also comprises detergent or foaming agent.The optional component that comprises in addition is flavoring agent and pigment, deodorizer, lubricant, thickening agent, emulsifying agent or plasticizer.
The optional component of useful in the present invention other is just like at United States Patent (USP) 4,515, the pyrophosphate described in 772 (on May 7th, 1985, the people such as Parran), at this as a reference.Also having some useful components is nonionic antibacterial, as United States Patent (USP) 4,894, and the described triclosan of 220 (January 16 nineteen ninety, people such as Nabi).Two patents are all quoted reference as proof at this.The example of such medicine comprises triclosan and other phenolic compound.
The another kind of medicine that compositions of the present invention is used is an alkali metal hydrogencarbonate, as sodium bicarbonate.These all are the commodity of stable supply, and can use with a kind of per-compound in compartment independently, as at United States Patent (USP) 4,894, disclosed in 213 and 4,528,180 (Schaeffer), quote as proof as a reference at this.
The useful mixture of freshener preferably comprises the mixture of one or more carboxylic acid amides and dihydroxylic alcohols in oral cavity composition.Freshener is measured preferably and is about 0.0500-0.2000 in the United States Patent (USP) 4320688, and the amount in the United States Patent (USP) 4136163 is about 0.0500-0.1000.
Medicine
Because cooling composition is to skin and oral cavity, larynx and nasal mucosa and gastrointestinal tract mucous cooling effect, it can be used for spray, the topical composition of oral drugs, nose and larynx, especially when a kind of counter-stimulus of needs.Particularly coolant compositions can be mixed with antacid and dyspepsia medicine, and particularly those comprise the medicine of sodium bicarbonate, magnesium oxide, calcium carbonate or magnesium, aluminium hydroxide or magnesium or magnesium trisilicate.
The oral pain alleviating compositions also can comprise coolant compositions, as situation, in as those nasal decongestants that contain ephedrine, also can comprise coolant compositions at aspirin or its salt, acetaminophen (acetamenophin), ibuprofen, naproxen and other propanoic derivatives.
To some compositions of the present invention be described by following indefiniteness example.These examples only are used for illustrative purposes, and the present invention is not construed as limiting, and under situation without departing from the spirit and scope of the present invention, can make various changes.
Embodiment 1
Provide an example of representative dentifrice composition of the present invention below.
1United States Patent (USP) 4,136,163 (on January 23rd, 1979, people such as Watson)
2United States Patent (USP) 4,230,688 (on October 28th, 1980, Rowwsell people)
| Component | Weight % |
| Sorbitol | 52.512 |
| Silicon dioxide | 20.000 |
| Water | 11.165 |
| Propylene glycol | 5.000 |
| Synthesis of alkyl sodium sulfate | 4.000 |
| Sodium bicarbonate | 1.5000 |
| Tertiary sodium phosphate | 1.450 |
| Flavoring agent | 1.000 |
| Sodium hydroxide | 0.600 |
| Mono phosphoric acid ester sodium | 0.590 |
| Titanium dioxide | 0.525 |
| Sodium fluoride | 0.243 |
| Xanthan gum | 0.475 |
| Saccharin sodium | 0.350 |
| Carbopol | 0.300 |
| WS-23 1 | 0.200 |
| WS-3 2 | 0.090 |
Embodiment 2-5
Be other toothpaste below.
| Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | |
| Compositions | Weight % | Weight % | Weight % | Weight % |
| Sorbitol | 52.512 | 47.223 | 22.514 | 39.750 |
| Silicon dioxide | 20.000 | 20.00 | 22.500 | 15.000 |
| Water | 11.165 | 10.201 | 23.261 | 10.000 |
| Propylene glycol | 5.000 | 5.000 | 5.000 | 5.000 |
| Synthesis of alkyl sodium sulfate | 4.000 | 5.000 | 4.000 | 4.000 |
| Sodium bicarbonate | 1.500 | 1.500 | 1.500 | 20.000 |
| Tertiary sodium phosphate | 1.450 | 1.330 | ||
| Flavoring agent | 1.000 | 0.963 | 0.900 | 1.000 |
| Sodium hydroxide | 0.600 | 0.600 | 0.600 | |
| Mono phosphoric acid ester sodium | 0.590 | 0.800 | ||
| Titanium dioxide | 0.525 | 0.500 | 0.350 | |
| Xanthan gum | 0.475 | 0.600 | ||
| Saccharin sodium | 0.350 | 0.330 | 0.460 | 0.517 |
| Carbopol | 0.300 | 0.220 | 0.200 | |
| WS-23 | 0.200 | 0.200 | 0.200 | 0.200 |
| WS-3 | 0.090 | 0.090 | 0.090 | 0.090 |
| Sodium fluoride | 0.243 | 0.243 | 0.243 | 0.243 |
| Glycerol | 5.000 | 4.000 | 2.000 | |
| Tetrapotassium pyrophosphate | 6.382 | |||
| PEG?300 | 3.000 | |||
| Sodium acid pyrophosphate | 2.100 | |||
| Tetrasodium pyrophosphate | 2.050 | |||
| The blue #1 of FD﹠C | 0.050 | 0.400 | ||
| Sodium carbonate | 1.000 | |||
| Carboxymethyl cellulose | 0.750 | 0.850 |
Embodiment 6
Be the representative example of collutory of the present invention below.
| Component | Weight % |
| Glycerol | ??7.5000 |
| Flavoring agent | ??0.1200 |
| Benzoic acid | ??0.0030 |
| Ethanol | ??8.5000 |
| PS (polysorbate 80) | ??0.1200 |
| Poloxomer?407 | ??0.2000 |
| Water | ??82.7291 |
| WS-23 | ??0.0500 |
| WS-3 | ??0.0250 |
| Propylene glycol | ??1.2500 |
| Sodium bicarbonate | ??0.3750 |
| Domiphen bromide | ??0.0050 |
| Cetylpyridinium chloride (cetylpyridinium chloride) | ??0.0450 |
| Saccharin sodium | ??0.0765 |
| Pigment | ??0.0014 |
Embodiment 7
Be the representative example of larynx drop of the present invention below.
| Component | Weight % |
| Propylene glycol | 0.500 |
| Sodium bicarbonate | 0.200 |
| WS-23 | 0.020 |
| WS-3 | 0.015 |
| Larynx drop substrate | Add to 100.00 |
Embodiment 8
Below for the representative example of chewing gum of the present invention.
| Component | Weight % |
| WS-23 | 0.200 |
| WS-3 | 0.090 |
| Propylene glycol | 2.000 |
| Sodium bicarbonate | 1.500 |
| Chewing gum base | Add to 100.00 |
Claims (13)
1. compositions, comprised a kind of dihydroxylic alcohols, a kind of coolant material and suitable carriers compositions, dihydroxylic alcohols is selected from propylene glycol, butanediol, hexanediol and composition thereof, it is characterized in that the pH value of described compositions, in mensuration compositions itself or when it uses, greater than about 8.2.
2. compositions as claimed in claim 1, its feature are that also freshener is selected from carboxylic acid amides, alcohol, ketal, glycol and composition thereof.
3. compositions as claimed in claim 1 or 2, its feature are that also described compositions contains a kind of bicarbonate as the pH regulator agent.
4. as the described compositions of arbitrary claim among the claim 1-3, its feature is that also described compositions contains a kind of bicarbonate as the pH regulator agent.
5. as the described compositions of arbitrary claim among the claim 1-4, its feature is that also its freshener is a carboxylic acid amides.
6. as the described compositions of arbitrary claim among the claim 1-5, its feature is that also described compositions is the form of toothpaste.
7. as the described compositions of arbitrary claim among the claim 1-6, it is characterized in that described compositions also contains a kind of abrasive in addition.
8. as the described compositions of arbitrary claim among the claim 1-7, it is characterized in that described compositions also contains a kind of soluble fluoride ion source in addition.
9. compositions as claimed in claim 4, its feature are that also its abrasive is the silicon dioxide abrasive.
10. compositions as claimed in claim 4, its feature are that also described compositions is the collutory form.
11. as the described compositions of arbitrary claim among the claim 1-4, its feature is that also described compositions is the form of cough drops.
12. as the described compositions of arbitrary claim among the claim 1-4, its feature is that also described compositions is a gum formats.
13. compositions as claimed in claim 8, its feature are that also described compositions contains bicarbonate in addition, and occupy the part of common adjustment container, another part of container contains a kind of peroxide source.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96192630 CN1179094A (en) | 1995-03-16 | 1996-02-20 | Coolant compositions |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/405,311 | 1995-03-16 | ||
| CN 96192630 CN1179094A (en) | 1995-03-16 | 1996-02-20 | Coolant compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1179094A true CN1179094A (en) | 1998-04-15 |
Family
ID=5128382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96192630 Pending CN1179094A (en) | 1995-03-16 | 1996-02-20 | Coolant compositions |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1179094A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103082399A (en) * | 2012-10-09 | 2013-05-08 | 方力 | Snuff and preparation method thereof |
| CN102215808B (en) * | 2008-11-20 | 2014-04-23 | 宝洁公司 | Personal care compositions providing enhanced cooling sensation |
| CN111084419A (en) * | 2012-04-30 | 2020-05-01 | 菲利普莫里斯生产公司 | Smoking article mouthpiece with cooling agent inclusion compound |
-
1996
- 1996-02-20 CN CN 96192630 patent/CN1179094A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102215808B (en) * | 2008-11-20 | 2014-04-23 | 宝洁公司 | Personal care compositions providing enhanced cooling sensation |
| CN111084419A (en) * | 2012-04-30 | 2020-05-01 | 菲利普莫里斯生产公司 | Smoking article mouthpiece with cooling agent inclusion compound |
| CN103082399A (en) * | 2012-10-09 | 2013-05-08 | 方力 | Snuff and preparation method thereof |
| CN103082399B (en) * | 2012-10-09 | 2015-02-04 | 方力 | Snuff and preparation method thereof |
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