CN117883217A - Individualized evaluation system for prosthetic valve-patient mismatch before transcatheter aortic valve replacement - Google Patents
Individualized evaluation system for prosthetic valve-patient mismatch before transcatheter aortic valve replacement Download PDFInfo
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- CN117883217A CN117883217A CN202311854224.4A CN202311854224A CN117883217A CN 117883217 A CN117883217 A CN 117883217A CN 202311854224 A CN202311854224 A CN 202311854224A CN 117883217 A CN117883217 A CN 117883217A
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- prosthetic valve
- pressure regulating
- regulating column
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- aortic valve
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- 210000001765 aortic valve Anatomy 0.000 title claims abstract description 35
- 238000011156 evaluation Methods 0.000 title abstract description 21
- 230000001105 regulatory effect Effects 0.000 claims abstract description 34
- 230000004872 arterial blood pressure Effects 0.000 claims abstract description 17
- 238000012360 testing method Methods 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims description 15
- 238000001356 surgical procedure Methods 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 5
- 208000032170 Congenital Abnormalities Diseases 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 206010010356 Congenital anomaly Diseases 0.000 description 3
- 238000012274 Preoperative evaluation Methods 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 210000005240 left ventricle Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000002861 ventricular Effects 0.000 description 3
- 210000000709 aorta Anatomy 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000002308 calcification Effects 0.000 description 2
- 230000000004 hemodynamic effect Effects 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 238000010146 3D printing Methods 0.000 description 1
- 206010002906 aortic stenosis Diseases 0.000 description 1
- 201000002064 aortic valve insufficiency Diseases 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 206010010371 congenital aortic valve stenosis Diseases 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 201000007119 infective endocarditis Diseases 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2472—Devices for testing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4851—Prosthesis assessment or monitoring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
- G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Cardiology (AREA)
- Veterinary Medicine (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Vascular Medicine (AREA)
- Pathology (AREA)
- Databases & Information Systems (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Data Mining & Analysis (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Business, Economics & Management (AREA)
- Business, Economics & Management (AREA)
- Prostheses (AREA)
Abstract
The invention provides a personalized evaluation system for a prosthetic valve-patient mismatch before a catheter aortic valve replacement operation, which comprises a test platform, a prosthetic valve mounting frame, a power pump arterial pressure regulating column and a venous pressure regulating column, wherein the test platform is arranged on the test platform; the sensor is electrically connected with the signal receiver, the signal receiver is electrically connected with the signal processor, and the signal processor is electrically connected with the display screen; the transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system enables surgical assessment prior to aortic valve replacement surgery, thereby reducing the risk of surgery.
Description
Technical Field
The invention belongs to the technical field of evaluation and prediction before aortic valve replacement, and particularly relates to a personalized evaluation system for prosthetic valve-patient mismatch before catheter aortic valve replacement.
Background
The normal aortic valve has three valves in total. When the heart contracts, three valves are simultaneously opened, and blood enters the aorta from the left ventricle; upon diastole, the three valves cooperatively close, preventing blood from flowing back from the aorta into the left ventricle. If the aortic valve is congenital with only two valves, called aortic valve bivalvulation, the most common congenital aortic valve stenosis deformity occurs at about 1% of the population. Often with aortic stenosis or insufficiency, and often with other congenital cardiovascular deformities. The most common of the infectious endocarditis of the aortic valve is aortic valve bivalvulation deformity.
For treating congenital aortic valve deficiency, aortic valve replacement can be used, and mechanical valve, biological valve, and homovalve can be selected. Generally, the surgical mortality rate is 1-2%. Elderly, female, aortic annulus, and ascending aortic wall severe calcification, aortic annulus small, combined with other heart operators, further increase the risk of surgery.
To reduce the risk of surgery, it is highly necessary to do a pre-operative evaluation of the aortic valve replacement procedure. However, no personalized evaluation system exists at present.
Disclosure of Invention
The invention aims to solve the problem of individualized evaluation of prosthetic valve-patient mismatch before aortic valve replacement operation so as to improve the success rate of aortic valve replacement operation for treating congenital defects of the aortic valve.
The invention provides an individual evaluation system for a prosthetic valve-patient mismatch before a catheter aortic valve replacement operation, which comprises a test platform, a prosthetic valve mounting frame, a power pump arterial pressure regulating column and a venous pressure regulating column, wherein the test platform is arranged on the test platform; the sensor is electrically connected with the signal receiver, the signal receiver is electrically connected with the signal processor, and the signal processor is electrically connected with the display screen.
Further, the prosthetic valve mounting bracket is provided with a detachable prosthetic valve.
Further, the sensor includes a plurality of pressure sensors and a plurality of flow sensors.
Further, the venous pressure regulating column and the arterial pressure regulating column are both cylindrical, and the diameter of the venous pressure regulating column is larger than that of the arterial pressure regulating column.
Further, the signal processor is also electrically connected with a buzzer.
Further, the sensor is electrically connected to a signal receiver, which is electrically connected to the computer.
The invention provides the individuation evaluation system for the mismatch between the prosthetic valve before the aortic valve replacement operation and the patient, which can perform operation evaluation before the aortic valve replacement operation, thereby reducing operation risk.
The invention will now be described in detail with reference to the drawings and examples.
Drawings
FIG. 1 is a block diagram of a personalized evaluation system for transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch.
Fig. 2 is a schematic diagram of a system for detecting a transcatheter aortic valve replacement pre-prosthetic valve-patient mismatch in a personalized evaluation system.
Fig. 3 is a schematic diagram of a second embodiment of a system for detecting a transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch by a personalized evaluation system.
Fig. 4 is a schematic diagram of a pressure regulating column.
Detailed Description
The following detailed description, structural features and functions of the present invention are provided with reference to the accompanying drawings and examples in order to further illustrate the technical means and effects of the present invention to achieve the predetermined objects.
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
All of the features disclosed in this specification, or all of the steps in a method or process disclosed, may be combined in any combination, except for mutually exclusive features and/or steps.
Any feature disclosed in this specification (including any accompanying claims, abstract and drawings), may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. That is, each feature is one example only of a generic series of equivalent or similar features, unless expressly stated otherwise.
Example 1
The embodiment provides a personalized evaluation system for a prosthetic valve-patient mismatch before a catheter aortic valve replacement operation shown in fig. 1-4, which comprises a test platform 1, a prosthetic valve mounting frame 2, a power pump 3, an arterial pressure regulating column 4 and a venous pressure regulating column 5, wherein the test platform 1 is provided with the prosthetic valve mounting frame 2, one end of the prosthetic valve mounting frame 2 is communicated with a liquid outlet end of the arterial pressure regulating column 4 through a pipeline 8, a liquid inlet end of the arterial pressure regulating column 4 is communicated with a liquid outlet end of the communicating venous pressure regulating column 5 through a pipeline 8, a liquid inlet end of the venous pressure regulating column 5 is communicated with a liquid outlet end of the power pump 3 through a pipeline 8, and a sensor 7 is further arranged at a liquid outlet end of the prosthetic valve mounting frame 2 communicated with the arterial pressure regulating column 4; the sensor 7 is electrically connected with a signal receiver, the signal receiver is electrically connected with a signal processor, and the signal processor is electrically connected with a display screen.
The power pump 3 employs a linear motor drive assembly that simulates ventricular systole and diastole by vertical, upward and downward movements. The power pump 3 reciprocates to simulate the ventricular operation, and the combination of the pipeline 8, the artificial valve 6, the arterial pressure regulating column 4 and the venous pressure regulating column 5 can simulate the hemodynamic characteristics of the human blood circulation system to generate parameters such as liquid pressure, flow and the like required by the test of the pulsation flow performance of the artificial heart valve. The linear motor simulates the heart beat function.
The power pump 3 is driven by a motor, the motor is controlled by a PWM controller to realize current control, namely pressure control, a driving waveform is generated by a computer, the driving waveform (left ventricle pressure waveform) can be randomly regulated according to the requirement of the test physiological condition, and an initial driving waveform is preset in a program.
In addition, the individualized evaluation system for the mismatch of the prosthetic valve and the patient before the catheter aortic valve replacement operation is further provided with a plurality of valves, and the valves are arranged at two ends of the prosthetic valve mounting frame 2, so that the operations of simulating blood, replacing the prosthetic valve and the like can be conveniently completed.
Further, the prosthetic valve mounting frame 2 is provided with a detachable prosthetic valve 6, so that the prosthetic valves of different patients can be replaced conveniently, and the preoperative evaluation is completed.
Further, the sensor 7 includes a plurality of pressure sensors and a plurality of flow sensors, so that the pressure and flow rate detection of the simulated blood flow environment can be completed, and the sensor can be arranged at a proper position in the pipeline 8 according to the detection requirement.
Further, as shown in fig. 4, the venous pressure regulating column 5 and the arterial pressure regulating column 4 are both cylindrical, and the diameter of the venous pressure regulating column 5 is larger than that of the arterial pressure regulating column 4, so that pressure difference between an artery and a vein can be formed, and the blood environment of the artery and the vein of a human body can be truly simulated.
Furthermore, the signal processor is also electrically connected with a buzzer, and when the detected pressure data and flow data exceed the normal range of the human body, a reminding sound can be sent out.
Further, the sensor 7 is electrically connected with a signal receiver, and the signal receiver is electrically connected with a computer, so that the signal receiver is another detection mode of the individual evaluation system for the mismatch between the prosthetic valve and the patient before the aortic valve replacement operation through the catheter, and the computer is used for identifying and displaying the detected pressure data and flow data, so that the preoperative evaluation of the prosthetic valve can be completed, and the evaluation result is convenient to further process.
In practical application, first, 3D printing of the artificial valve is performed, and the specific process is as follows: after CTA/TTE/CMR image data acquisition, the image data are stored in DIGITAL IMAGING AND Communications IN MEDICINE (DICOM) format and imported into MATERIALISE MIMICS 21.0.0 (Leuven, belgium) software. The interactive multi-plane reconstruction imaging function in software is utilized to obtain the optimal lesion area image. And then, segmenting the aortic root by using a threshold segmentation function, and carrying out contour sketching to carry out three-dimensional reconstruction and analysis so as to obtain an initial aortic root three-dimensional model. And then, using material 3-matrix (Leuven, belgium) software to perform digital processing such as cutting, smoothing, repairing, shell extraction and the like on the obtained aortic root three-dimensional model, completely restoring the aortic root structure, the valve leaflet morphology and calcification distribution, and finally exporting the digital model through a Standard Tessellation Language (STL) format file. And importing the STL file into STRATASYS POLYJET-850 multi-material full-color 3D printer, selecting different materials according to different organizations to match, and then finishing printing.
Then, the printed artificial valve is arranged on the artificial valve mounting frame 2, the debugging of an individual evaluation system of the artificial valve-patient mismatch before the aortic valve replacement operation is carried out, after the normal operation of each component is determined, the evaluation parameters of the system are set, the evaluation can be carried out, the flow velocity data and the pressure data are obtained through the pressure sensor and the flow sensor, the test can be completed, and the parameters such as the liquid pressure, the waveform, the flow and the like required by the implantation of the biological valve are obtained, so that the effective valve orifice area is obtained.
The personalized evaluation system for the mismatch of the prosthetic valve and the patient before the aortic valve replacement operation through the catheter adopts the linear motor to drive the component to reciprocate to simulate the operation of a ventricular pump, and combines a runner, a valve, a damping and compliance adjusting mechanism with a specific structure to simulate the hemodynamic characteristics in a circulatory system and generate parameters such as liquid pressure, waveform, flow and the like required by the pulsating flow performance test of the biological valve, thereby obtaining the effective valve orifice area.
The foregoing is a further detailed description of the invention in connection with the preferred embodiments, and it is not intended that the invention be limited to the specific embodiments described. It will be apparent to those skilled in the art that several simple deductions or substitutions may be made without departing from the spirit of the invention, and these should be considered to be within the scope of the invention.
Claims (6)
1. A transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system, characterized by: the device comprises a test platform (1), a prosthetic valve mounting frame (2), a power pump (3), an arterial pressure regulating column (4) and a venous pressure regulating column (5) which are arranged on the test platform (1), wherein one end of the prosthetic valve mounting frame (2) is communicated with the liquid outlet end of the arterial pressure regulating column (4) through a pipeline (8), the liquid inlet end of the arterial pressure regulating column (4) is communicated with the liquid outlet end of the communicated venous pressure regulating column (5) through a pipeline (8), the liquid inlet end of the venous pressure regulating column (5) is communicated with the liquid outlet end of the power pump (3) through a pipeline (8), and the liquid outlet end of the prosthetic valve mounting frame (2) communicated with the arterial pressure regulating column (4) is also provided with a sensor (7); the sensor (7) is electrically connected with the signal receiver, the signal receiver is electrically connected with the signal processor, and the signal processor is electrically connected with the display screen.
2. A transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system, characterized by: the prosthetic valve mounting frame (2) is provided with a detachable prosthetic valve (6).
3. The transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system of claim 1, wherein: the sensor (7) comprises a plurality of pressure sensors and a plurality of flow sensors.
4. The transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system of claim 1, wherein: the venous pressure regulating column (5) and the arterial pressure regulating column (4) are cylindrical, and the diameter of the venous pressure regulating column (5) is larger than that of the arterial pressure regulating column (4).
5. The transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system of claim 1, wherein: the signal processor is also electrically connected with a buzzer.
6. The transcatheter aortic valve replacement preoperative prosthetic valve-patient mismatch personalized assessment system of claim 1, wherein: the sensor (7) is electrically connected to a signal receiver, which is electrically connected to the computer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311854224.4A CN117883217A (en) | 2023-12-29 | 2023-12-29 | Individualized evaluation system for prosthetic valve-patient mismatch before transcatheter aortic valve replacement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311854224.4A CN117883217A (en) | 2023-12-29 | 2023-12-29 | Individualized evaluation system for prosthetic valve-patient mismatch before transcatheter aortic valve replacement |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117883217A true CN117883217A (en) | 2024-04-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311854224.4A Pending CN117883217A (en) | 2023-12-29 | 2023-12-29 | Individualized evaluation system for prosthetic valve-patient mismatch before transcatheter aortic valve replacement |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117883217A (en) |
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2023
- 2023-12-29 CN CN202311854224.4A patent/CN117883217A/en active Pending
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