CN117860310A - Adhesive bag, adhesive assembly and cavity mucus sampling device - Google Patents

Abstract

The invention relates to an adhesive bag, an adhesive assembly and a cavity mucus sampling device. Wherein the adhesive pouch comprises: the elastic bag comprises an elastic bag wall with elasticity and a first inner cavity wrapped in the elastic bag wall; an adhesive part which is sheet-shaped and made of a material having ductility and is used for adhering a cavity tract mucus sample; the adhesive part is adhered to the peripheral wall of the elastic bag and is detachably connected with the elastic bag; the adhesive bag comprises a contracted state and an expanded state, and in the contracted state, the elastic bag is of a tubular structure with one end provided with a first opening, wherein the first opening is used for filling or discharging fluid substances into or out of the first inner cavity; in the expansion state, the elastic bag is spherical or ellipsoidal, and fluid substances are controlled to be filled into or discharged from the first inner cavity, so that the elastic bag is driven to be switched between the expansion state and the contraction state, and meanwhile, the adhesion part is driven to deform, and therefore the problems that the mucous membrane is easily damaged in the sampling process and the collection effect is poor are solved.

Description

Adhesive bag, adhesive assembly and cavity mucus sampling device

Technical Field

The invention relates to the technical field of medical instruments, in particular to an adhesive bag, an adhesive assembly and a cavity mucus sampling device.

Background

The mucous membrane is a membranous structure formed by epithelial tissues and connective tissues in organisms (inside organs such as oral cavity, organs, stomach, intestines and urethra), and mucus is a viscous liquid secreted from a mucous membrane layer or submucosa of a human body, forms a mucous barrier attached to the mucous membrane surface of the human body, is commonly called a mucous membrane layer in medicine, and can play a role in protecting and lubricating the mucous membrane.

For example, the mucous layer at the colon is about 830.+ -.110. Mu.m, and in particular, the mucous layer is divided into two layers, the outer one being a loose mucous layer and the inner one being a tightly adhering mucous layer. The colonic mucus layer is used as a barrier for isolating intestinal contents and epithelial cells, is also a first barrier, the structural and functional integrity of the colonic mucus layer plays a very important role on the health of a human body, and theoretically, even the thickness of the mucus layer can be directly used for reflecting the antigen amount received by an intestinal immune system, the thicker the mucus layer is, the farther the intestinal contents (food, bacteria, fungi, viruses and the like) are away from the intestinal epithelial cells, the less the antigen amount borne by the intestinal immune system is, the thinner the mucus layer is, the smaller the distance between the intestinal contents and the epithelial cells is, the more antigen stimulation is borne by the intestinal immune system, once the mucus layer is directly destroyed, the intestinal contents are directly contacted with the epithelial cells, and a strong immune response is initiated, which is probably one reason that colonitis occurs. Therefore, the collection of mucus in the mucus layer of the lumen is of great importance for the study and diagnosis of diseases in the body lumen, and helps to understand the pathogenesis of early stages of the disease and develop early diagnostic kits.

At present, the mucus sampling in the alimentary canal can be realized after a sampling device is matched with an endoscope biopsy pore canal. The sampling devices reported in the published patent documents (such as CN116439751 a) are mostly hard instruments, but due to the thin wall of the digestive tract, mucous membranes are easily damaged in the sampling process, and the endoscopic sampling requires high requirements on the operation method and skill of the operator. In addition, the long digestive tract, the sampled sample is easily contaminated by non-sampling points, and is also an important factor limiting the use of mucus samples.

Disclosure of Invention

In order to solve the problems that mucous membrane is easily damaged in the sampling process and the collection effect is poor, the invention provides an adhesive bag, an adhesive assembly and a cavity mucus sampling device.

The present invention provides in a first aspect an adhesive bladder comprising:

the elastic bag comprises an elastic bag wall with elasticity and a first inner cavity wrapped in the elastic bag wall; an adhesive part which is sheet-shaped and made of a material having ductility and is used for adhering a cavity tract mucus sample; the adhesive part is adhered to the peripheral wall of the elastic bag and is detachably connected with the elastic bag; the adhesive bag comprises a contracted state and an expanded state, and in the contracted state, the elastic bag is of a tubular structure with one end provided with a first opening, wherein the first opening is used for filling or discharging fluid substances into or out of the first inner cavity; in the expanded state, the elastic bag is spherical or ellipsoidal, and fluid substances are controlled to be filled into or discharged from the first inner cavity, so that the elastic bag is driven to be switched between the expanded state and the contracted state, and meanwhile, the adhesion part is driven to deform.

In some embodiments, the adhesive portions are provided in plurality and are respectively disposed at intervals in the circumferential direction of the elastic bag.

In some embodiments, the adhesive portion is a strip-shaped sheet structure and extends in the axial direction of the elastic bag, and a space is provided between an end of the adhesive portion in the longitudinal direction and an end of the elastic bag in the axial direction.

The second aspect of the present invention also provides an adhesive assembly comprising: an adhesion unit and a gas path unit; the adhesive unit comprises the adhesive bladder of any of the embodiments of the first aspect; the gas path unit is connected with the first opening in a sealing way and enables fluid substances to be filled into or discharged out of the first inner cavity through the first opening.

In some embodiments, the adhesive unit comprises a plurality of adhesive capsules, the elastic capsules of the plurality of adhesive capsules are connected in sequence and the first inner cavities are communicated with each other; the elastic bag is also provided with a second opening, the second opening is arranged at one end of the elastic bag far away from the first opening, and the first opening of one elastic bag in two adjacent elastic bags is communicated with the second opening of the other elastic bag.

In some embodiments, the adhesive unit comprises two adhesive bladders; the air path unit comprises an air supply pipe and an exhaust pipe, and the first end of the air supply pipe is communicated with the first opening of one of the adhesive bags; the first end of the exhaust pipe extends into the first inner cavities of the two adhesive bags through the first end of the air supply pipe and extends to the second opening of the adhesive bag far away from the air supply pipe.

In some embodiments, the gas supply tube is sleeved outside the gas exhaust tube, and a gap is provided between the inner side wall of the gas supply tube and the outer side wall of the gas exhaust tube.

In some embodiments, the adhesive assembly further comprises a spacer sleeve, the spacer sleeve being tubular, the spacer sleeve being disposed outside the gas supply tube, a gap being provided between an inner sidewall of the spacer sleeve and an outer sidewall of the gas supply tube, the spacer sleeve having a receiving cavity for receiving the plurality of adhesive pockets in the contracted state, the adhesive pockets in the contracted state being disposed to extend out of or into the receiving cavity along an extension direction of the spacer sleeve.

In some embodiments, the adhesive assembly further comprises a telescoping unit comprising a bellows and a throttle plate, wherein the bellows is capable of being elongated or shortened in an axial direction, one end of the bellows is in communication with the gas supply tube, the other end of the bellows is in communication with the first opening of the adhesive bladder adjacent the gas supply tube, and the vent tube passes through the bellows in the axial direction; the throttle plate is arranged at the joint of the corrugated hose and the adhesive bag, and is provided with a plurality of through holes, wherein the sum of the sectional areas of the through holes is 5% -10% of the diameter of the air supply pipe; the bellows has an extended state and a shortened state, and the bellows is driven to switch between the extended state and the shortened state by controlling the flow of fluid substances into or out of the bellows;

In the extension state, the corrugated hose drives the adhesive bag to extend out of the accommodating cavity along the extension direction of the isolation sleeve;

in the shortened state, the corrugated hose drives the adhesive bag to enter the storage cavity along the extending direction of the isolation sleeve.

In some embodiments, the adhesion assembly further comprises a blocking unit comprising a blocking bladder in a bladder-like structure and provided with a third opening connected to the second opening of the adhesion bladder remote from the gas supply tube, and a one-way valve provided at the third opening, the one-way valve being arranged to allow one-way flow of the fluid substance into the blocking bladder;

the blocking bag comprises a first state and a second state, wherein the blocking bag is free of fluid substances and is contracted inwards in the first state, the blocking bag is in an expanded state under the drive of the flowing substances in the second state, the blocking bag in the second state is in a spherical shape, and the diameter of the blocking bag is larger than the inner diameter of the isolation sleeve.

In some embodiments, the adhesion component further comprises a support ring, the support ring is arranged at the first opening and the second opening of the adhesion bag, the support ring comprises an outer ring body, an inner ring body and connecting ribs connected between the inner ring body and the outer ring body, the outer ring body is sleeved on the outer peripheral surface of the first opening and fixedly connected to the outer peripheral surface of the adhesion bag, the inner ring body is sleeved on the outer side wall of the exhaust pipe and is attached to the outer side wall of the exhaust pipe, the connecting ribs are in a stick shape and are provided with a plurality of pieces, the connecting ribs penetrate through the side wall of the adhesion bag, two ends of the connecting ribs are connected with the inner ring body and the outer ring body respectively, and the connecting ribs penetrate through the position of the adhesion bag to be sealed.

The third aspect of the present invention also provides a device for sampling a mucus in a lumen, comprising: the hose assembly comprises a probe unit and an extension pipe which are sequentially connected, wherein the probe unit comprises a seat body, the seat body is columnar and is provided with a plurality of mounting holes penetrating through the seat body along the axial direction, and the plurality of mounting holes are arranged at intervals along the circumferential direction of the seat body;

the monitoring component is used for monitoring the state of the adhesion component;

the adhesive assembly and the monitoring assembly are disposed through the extension tube and through different mounting holes, respectively.

In some embodiments, the luminal mucus sampling device further comprises a control assembly comprising an air supply unit, an air exhaust unit, a liquid supply unit, a drive unit, and a controller;

the air supply unit is communicated with the air path unit and supplies fluid substances, the air exhaust unit is communicated with the air path unit and discharges the fluid substances, the liquid supply unit comprises a liquid supply pipe penetrating through the mounting hole and spraying flushing liquid into a human body through the liquid supply pipe, and the driving unit drives the hose assembly to extend into the human body;

the controller is used for controlling the actions of the air supply unit, the air exhaust unit, the liquid supply unit, the driving unit and the monitoring component.

In order to solve the problems that the mucous of the cavity is easy to be damaged in the sampling process and the collection effect is poor, the invention has the following advantages:

the adhesion capsule in the contracted state has smaller volume, can be matched with devices such as an endoscope and can be smoothly stretched into a position where the cavity mucus is required to be sampled, and then fluid substances are filled in the adhesion capsule to expand the adhesion capsule, so that the adhesion part arranged on the outer side wall can be fully contacted with the inner wall of the digestive tract and exert certain force, the cavity mucus can be attached to the adhesion part, and the elastic capsule is filled with the fluid substances at the moment, so that the force exerted when sampling the digestive tract wall is softer, and the bruise is not easy to occur. In addition, the adhesion part has ductility, because the surface area of the elastic bag will increase under the driving action of fluid substances in the expanding process, and then make the adhesion part attached at the elastic bag lateral surface take place to stretch, and then make the adhesion part become loose structure by comparatively dense structure, thereby the cavity way mucus of adhesion waiting to take a sample more easily, and make it be difficult to take place to drop, and further, when the elastic bag contracts, the adhesion part is retracted along with the elastic bag surface area reduction, can more closely adhere the sample on the adhesion part when becoming dense again, prevent that the sample from taking place to drop, and the sampling efficiency is higher.

Drawings

FIG. 1 shows a schematic structural view of an inflated state of an adhesive bladder of an embodiment;

FIG. 2 shows a schematic structural view of an embodiment of a contracted state of an adhesive bladder;

FIG. 3 is a schematic cross-sectional view showing an inflated state of an adhesive bag according to an embodiment;

FIG. 4 illustrates a schematic structural view of one operational state of the adhesive assembly of one embodiment;

FIG. 5 illustrates a schematic structural view of another operational state of the adhesive assembly of one embodiment;

FIG. 6 shows a schematic cross-sectional structure of FIG. 4;

FIG. 7 is a schematic view showing a partially enlarged structure of the portion A in FIG. 6;

FIG. 8 is a schematic view showing a partially enlarged structure of the portion B in FIG. 6;

FIG. 9 illustrates a schematic structural view of a hose assembly of one embodiment;

FIG. 10 is a schematic diagram showing the structure of a device for sampling a mucus in a lumen of an embodiment;

FIG. 11 is a schematic diagram showing a control mode of a controller of the luminal mucus sampling device according to an embodiment;

FIG. 12 illustrates a component relationship diagram of a detection assembly of one embodiment.

Reference numerals:

10-hose assembly; 11-extension pipe; 12-a probe unit; 121-a base; 122-a first mounting hole; 123-a second mounting hole; 124-a third mounting hole; 125-fourth mounting holes; 20-an adhesive assembly; 21-an air path unit; 211-a gas supply pipe; 212-exhaust pipe; 22-telescoping units; 221-corrugated hose; 222-a throttle plate; 23-adhesion units; 231-a support ring; 2311-an outer ring; 2312-an inner ring body; 2313-connecting ribs; 232-an adhesive sac; 2321-elastic bladder; 23211-first lumen; 2322-an adhesive; 2323—a first opening; 2324-a second opening; 24-occlusion unit; 241-occlusion balloon; 2411-a second lumen; 242-a one-way valve; 25-isolating sleeve; 251-a receiving cavity; 30-monitoring the assembly; 31-a lighting unit; 311-lighting lamp; 312-a first line; 32-an acquisition unit; 321-a camera; 322-second line; 41-an air supply unit; 42-an exhaust unit; 43-a liquid supply unit; 44-a drive unit; 45-controller.

Detailed Description

The disclosure will now be discussed with reference to several exemplary embodiments. It should be understood that these embodiments are discussed only to enable those of ordinary skill in the art to better understand and thus practice the present disclosure, and are not meant to imply any limitation on the scope of the present disclosure.

As used herein, the term "comprising" and variants thereof are to be interpreted as meaning "including but not limited to" open-ended terms. The term "based on" is to be interpreted as "based at least in part on". The terms "one embodiment" and "an embodiment" are to be interpreted as "at least one embodiment. The term "another embodiment" is to be interpreted as "at least one other embodiment". The terms "upper", "lower", "left", "right", "front", "rear", "top", "bottom", "inner", "outer", "vertical", "horizontal", "transverse", "longitudinal", etc. refer to an orientation or positional relationship based on that shown in the drawings. These terms are used primarily to better describe the present application and its embodiments and are not intended to limit the indicated device, element or component to a particular orientation or to be constructed and operated in a particular orientation. Also, some of the terms described above may be used to indicate other meanings in addition to orientation or positional relationships, for example, the term "upper" may also be used to indicate some sort of attachment or connection in some cases. The specific meaning of these terms in this application will be understood by those of ordinary skill in the art as appropriate. Furthermore, the terms "mounted," "configured," "provided," "connected," and "connected" are to be construed broadly. For example, it may be a fixed connection, a removable connection, or a unitary construction; may be a mechanical connection, or an electrical connection; may be directly connected, or indirectly connected through intervening media, or may be in internal communication between two devices, elements, or components. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art as the case may be. Furthermore, the terms "first," "second," and the like, are used primarily to distinguish between different devices, elements, or components (the particular species and configurations may be the same or different), and are not used to indicate or imply the relative importance and number of devices, elements, or components indicated. Unless otherwise indicated, the meaning of "a plurality" is two or more.

This embodiment discloses an adhesive balloon 232, as shown in fig. 1, 2 and 3, which may include: the elastic bag 2321, the elastic bag 2321 including a wall of the elastic bag 2321 having elasticity and a first inner cavity 23211 enclosed within the wall of the elastic bag 2321; an adhering portion 2322, the adhering portion 2322 being sheet-shaped and made of a material having ductility and being used for adhering a luminal mucus sample; the adhesion part 2322 is attached to the outer peripheral wall of the elastic bag 2321 and is detachably connected with the elastic bag 2321; the adhesive bladder 232 includes a contracted state and an expanded state, in which the elastic bladder 2321 is a tubular structure having a first opening 2323 disposed at one end, wherein the first opening 2323 is used to fill or drain a fluid substance into or out of the first lumen 23211; in the expanded state, the elastic balloon 2321 takes a spherical or ellipsoidal shape, and the fluid substance is controlled to be filled into or discharged from the first inner cavity 23211, so that the elastic balloon 2321 is driven to switch between the expanded state and the contracted state, and the adhesion portion 2322 is driven to deform.

In this embodiment, as shown in fig. 2, the contracted state of the adhesive sac 232 has a smaller volume, and can be matched with an endoscope or other device to smoothly extend into a position where a luminal mucus sampling is required, and then the adhesive sac 232 is inflated with a fluid substance to become a state as shown in fig. 1, so that the adhesive portion 2322 provided on the outer side wall can be sufficiently contacted with the inner wall of the digestive tract and exert a certain force, and the mucous membrane can be attached to the adhesive portion, and because the elastic sac 2321 is filled with the fluid substance at this time, the force is softer and the bruise is less likely to occur when the digestive tract wall is sampled. In addition, the adhesion portion 2322 has ductility, because the surface area of the elastic bag 2321 will be increased under the driving action of the fluid substance in the expanding process, the adhesion portion 2322 attached to the outer side surface of the elastic bag 2321 is stretched, and the adhesion portion 2322 is changed into a loose structure from a compact structure, so that the cavity mucus to be sampled is adhered more easily, and is not easy to fall off, and further, when the elastic bag 2321 is contracted, the adhesion portion 2322 is retracted together with the reduction of the surface area of the elastic bag 2321, and the sample can be adhered to the adhesion portion 2322 more tightly while the compactness is achieved again, so that the sample is prevented from falling off.

The elastic bag 2321 can be made of medical rubber and other materials, namely has good biocompatibility and good elasticity, and can bear certain pressure without damage in the expansion process. In actual operation, the volume inflated by the elastic bladder 2321 may be precisely controlled by detecting the pressure fed back by the fluid substance in the elastic bladder 2321, and of course, the inflation of the elastic bladder 2321 may be monitored by a visual device such as an endoscope, so as to prevent the rupture thereof. Furthermore, the structure such as the reinforcing rib can be arranged on the wall of the elastic bag 2321, the reinforcing rib can be made of the same material as the elastic bag 2321, and can also be an elastic framework, so that the elastic bag 2321 can be further prevented from being broken, the expanded shape of the elastic bag 2321 can be controlled through the arrangement of the framework, the elastic bag 2321 can be made to be in a spherical, ellipsoidal, spindle-shaped, hemispherical or other structure, the outer surface of the elastic bag 2321 can be controlled to be provided with a convex or concave structure, the operation can be conveniently carried out, the sample can be further obtained, the sample can be prevented from falling off, the special shape can be also be conveniently shown, the endoscope can be conveniently observed through the endoscope, a larger visual field can be provided for the endoscope, and the operation is convenient. The adhesion portion 2322 has a certain ductility, a relatively dense fiber sheet formed by fibers may be used as the adhesion portion 2322, or a stretchable structure such as waves may be used, for example, a fiber sheet made of fibers is used as an example, the elastic bag 2321 is illustrated as a sphere in fig. 1 after being inflated, when the elastic bag 2321 is inflated, the adhesion portion 2322 stretches along with the inflation of the elastic bag 2321, particularly, the inflation of the elastic bag 2321 is strongest at the middle position along the axial direction, after the fiber sheet is stretched, a larger gap is generated between the fibers, and as the cavity mucus is a relatively thick colloid which is rich in a large amount of water and is provided with a certain viscosity and contains detached mucosal epithelial cells, biological membranes and the like, the gap between the fibers can fully absorb the mucus and simultaneously enable substances in the mucus to be fully attached to the fibers. When the elastic bag 2321 contracts, the adhesion part 2322 is driven to retract together and is changed into an initial state again, at this time, gaps between fibers are reduced, so that mucus can be captured by the fibers, and the mucus is difficult to fall off from the adhesion part 2322, and therefore the sampling effect is effectively improved. After sampling, the attachment portion 2322 may be detached from the elastic bladder 2321, and the sampled mucus may be separated from the attachment portion 2322 by treating it (e.g., placing it in a specific solution). The fluid material filled in the first cavity may be a gas or a liquid, preferably, a gas is used, because the gas can be filled or discharged from the elastic bag 2321 quickly, and the control is easy, specifically, compressed air can be selected, so that the safety is improved, and the introduced gas can be subjected to sufficient sterilization and disinfection treatment. If a liquid is used as the fluid substance to be introduced, the elastic bladder 2321 may be more flexible after inflation, and less harmful to the wall of the digestive tract during sampling.

As a further embodiment, since the extensibility and retractability of the adhesive portions 2322 may be weaker than those of the material of the elastic bag 2321, further expansion of the elastic bag 2321 may be hindered when it is expanded to a certain extent, and thus, as shown in fig. 1 and 2, the adhesive portions 2322 are provided in plurality and are respectively provided at intervals in the circumferential direction of the elastic bag 2321.

By distributing the adhesive portions 2322 along the circumferential direction of the elastic bag 2321 at intervals, the wall of the elastic bag 2321 at the interval portion between the adhesive portions 2322 can be fully stretched, the adhesive bag 232 in an expanded state is more in accordance with the expected shape, and meanwhile, the situation that the adhesive portions 2322 are excessively stretched under the driving of the elastic bag 2321, so that the adhesive portions 2322 are damaged or the ductility of the adhesive portions 2322 is damaged, the adhesive portions 2322 are difficult to retract, and sampling is affected can be avoided.

Similarly, both ends of the elastic bladder 2321 in the axial direction are required to be inflated despite the small inflation rate, and therefore, as shown in fig. 1 and 2, the adhering portion 2322 is of a strip-shaped sheet structure and is provided to extend in the axial direction of the elastic bladder 2321, and a space is provided between the end in the longitudinal direction of the adhering portion 2322 and the end in the axial direction of the elastic bladder 2321.

By the above embodiment, the influence of the adhesive portion 2322 on the expansion of the elastic bag 2321 is effectively avoided, and in addition, since the two ends of the adhesive portion 2322 are generally used for being connected with other parts, the adhesive portion 2322 can be rarely contacted with the cavity mucus, and the space is arranged at the positions, so that the use of materials of the adhesive portion 2322 can be reduced.

The second aspect of the present application also provides an adhesive assembly 20, as shown in fig. 4, 5 and 6, which in this embodiment may include: an adhesion unit 23 and a gas path unit 21; the adhesion unit 23 includes an adhesion bladder 232 in any of the embodiments of the first aspect; the gas cell 21 is sealingly connected to the first opening 2323 and charges or discharges fluid substances into or out of the first interior chamber 23211 via the first opening 2323.

In this embodiment, the first lumen 23211 of the adhesive balloon 232 can be filled with or drained of a fluid substance by the provision of the air circuit unit 21 to switch between an expanded state and a contracted state. The air path unit 21 may be configured to fill or drain the fluid material into or out of the first inner cavity 23211 by using one or more delivery pipes that are connected to the elastic bladder 2321, where the multiple delivery pipes may be sleeved or separately provided, and are hermetically connected to a position connected to the first opening 2323 of the elastic bladder 2321 to prevent leakage. The adhesion module 20 of this embodiment may be optionally extended into the alimentary canal together with an endoscope, etc., and since the other end of the air path unit 21 will extend outside the patient, the operation of the adhesion capsule 232 in the alimentary canal may be controlled by operating the extended air path unit 21 or the endoscope, etc., to complete the sampling operation.

In order to be able to extend adaptively into the digestive tract, in particular the intestinal tract, of a patient, the tubular structures used in the present application are therefore all made of a material having a certain flexibility.

To enhance the sampling effect or sampling area, a plurality of adhesive bags 232 may be optionally provided, as shown in fig. 4 and 5, the adhesive unit 23 includes a plurality of adhesive bags 232, elastic bags 2321 of the plurality of adhesive bags 232 are sequentially connected and the first inner cavities 23211 are mutually communicated; the elastic bag 2321 is further provided with a second opening 2324, the second opening 2324 is arranged at one end of the elastic bag 2321 far away from the first opening 2323, and the first opening 2323 of one elastic bag 2321 of two adjacent elastic bags 2321 is communicated with the second opening 2324 of the other elastic bag 2321.

That is, a plurality of adhesive capsules 232 are sequentially connected in series as shown in the drawing, wherein the first lumens 23211 of the plurality of adhesive capsules 232 communicate with each other, and fluid substances can be simultaneously filled or discharged, thereby controlling expansion or contraction thereof. The attachment locations of the plurality of adhesive cuffs 232 may be flexible enough to allow the plurality of adhesive cuffs 232 to naturally conform to the patient's digestive tract orientation, and to be adapted for sampling at a sampling location having a bend angle. In addition, the number of the adhesive pockets 232 should not be too large, and too many adhesive pockets 232 are too long in the axial direction after being sequentially connected, which may cause difficulty in handling, and affect the sampling operation, and specifically, may be set to 1-4, preferably, 2.

In addition, as shown in fig. 6, 7 and 8, the adhesion unit 23 includes two adhesion capsules 232; the gas path unit 21 includes a gas supply pipe 211 and a gas discharge pipe 212, a first end of the gas supply pipe 211 being communicated with a first opening 2323 of one of the adhesive capsules 232; the first end of the exhaust pipe 212 extends through the first end of the gas supply pipe 211 into the first lumen 23211 of the two adhesive bladders 232 and extends to a second opening 2324 of the adhesive bladder 232 remote from the gas supply pipe 211.

I.e., two adjacent adhesive capsules 232, the second opening 2324 of the first adhesive capsule 232 is communicated with the first opening 2323 of the second adhesive capsule 232, such that after the plurality of adhesive capsules 232 are sequentially connected, as shown in fig. 6 and 7, the first opening 2323 of the first adhesive capsule 232 of the adhesive capsules 232 is connected with the air supply pipe 211, and further, the exhaust pipe 212 is sequentially passed through the first cavities of the adhesive capsules 232, as shown in fig. 8, until reaching the second opening 2324 of the last adhesive capsule 232. The arrangement allows the plurality of adhesive capsules 232 to be inflated by filling the fluid material from a position close to the air supply tube 211, and the exhaust process is reversed, so that the fluid material can be discharged from the one adhesive capsule 232 farthest from the digestive tract, and the exhaust tube 212 can easily move axially relative to the exhaust tube 212 due to the gap provided between the exhaust tube 212 and the air supply tube 211, and after the fluid material in the farthest one adhesive capsule 232 is exhausted, the extending end of the exhaust tube 212 can be gradually moved toward the direction close to the air supply tube 211, so that the fluid material can be sufficiently discharged. In addition, since the air supply pipe 211 and the air discharge pipe 212 are both made of a flexible material, it is easier to pull the air discharge pipe 212 outwardly while pushing the air discharge pipe 212 inwardly is difficult, which is also why the initial position of the air discharge pipe 212 is set at the second opening 2324 extending to the adhesive pocket 232 away from the air supply pipe 211 at one end.

As a specific embodiment, as shown in fig. 6, the air supply pipe 211 is fitted over the outer side of the exhaust pipe 212, and a gap is provided between the inner side wall of the air supply pipe 211 and the outer side wall of the exhaust pipe 212.

It should be noted that the air supply tube 211 and the air exhaust tube 212 need to extend continuously to the outside of the patient and be connected to the air supply device or the air exhaust device, and the air supply tube 211 and the air exhaust tube 212 are shown only by way of example and not limitation of the present application. The gas supply pipe 211 and the gas exhaust pipe 212 are sleeved in order to reduce the connection interface with the first opening 2323 of the elastic bag 2321, as shown in the figure, only the connection part of the gas supply pipe 211 and the first opening 2323 needs to be sealed, and the structure is simplified, so that gas leakage can be effectively prevented. Alternatively, the air supply pipe 211 and the air discharge pipe 212 may be arranged opposite to those shown in the drawings, that is, the air discharge pipe 212 is fitted to the outside of the air supply pipe 211. Meanwhile, the exhaust pipe 212 is sleeved on the inner side of the air supply pipe 211 and is not in contact with the alimentary canal of the patient, so that damage to the alimentary canal of the patient due to repeated drawing devices can be effectively avoided.

In order to better prevent the collected samples from falling off and polluting during the transportation process outside the patient, as shown in fig. 4, 5 and 6, the adhesion assembly 20 further comprises a spacer sleeve 25, the spacer sleeve 25 is tubular, the spacer sleeve 25 is arranged on the outer side of the air supply pipe 211, a gap is arranged between the inner side wall of the spacer sleeve 25 and the outer side wall of the air supply pipe 211, the spacer sleeve 25 is provided with a containing cavity 251 for containing a plurality of adhesion bags 232 in a contracted state, and the adhesion bags 232 in a contracted state are arranged to extend out of or enter the containing cavity 251 along the extending direction of the spacer sleeve 25.

Through the setting of spacer 25, can accomodate the adhesion bag 232 that is in the shrink state completely in accomodating the chamber 251, then when gathering the end and taking out the sample to the alimentary canal outside, adhesion bag 232 remains in accomodating the chamber 251 all the time, from this, can effectively avoid the sample to suffer the pollution of the mucous membrane of non-sampling point at the in-process of taking out, or because friction leads to droing. In addition, in the process of endoscopy, sterile water is often injected to flush the mucous membrane so as to achieve the purposes of cleaning the operative field, removing impurities and the like, but the sterile water is accumulated in the digestive tract to generate effusion, the effusion also contaminates the sample in the process of taking out the sample, and the arrangement of the isolation sleeve 25 can also prevent the effusion from polluting the sample, thereby improving the quality of the sample and the collection efficiency.

In addition, in order to conveniently drive the adhesive bladder 232 in the contracted state to extend or enter the receiving chamber 251, as shown in fig. 6 and 7, the adhesive assembly 20 further includes a telescopic unit 22, the telescopic unit 22 including a bellows hose 221 and a throttle plate 222, wherein the bellows hose 221 is capable of being elongated or shortened in an axial direction, one end of the bellows hose 221 is communicated with the air supply pipe 211, the other end of the bellows hose 221 is communicated with a first opening 2323 of the adhesive bladder 232 adjacent to the air supply pipe 211, and the exhaust pipe 212 passes through the bellows hose 221 in the axial direction; the throttle plate 222 is arranged at the joint of the corrugated hose 221 and the adhesive bag 232, and a plurality of through holes are arranged on the throttle plate 222, wherein the sum of the sectional areas of the through holes is 5% -10% of the diameter of the air supply pipe 211; the bellows 221 has an extended state and a shortened state, and the bellows 221 is driven to switch between the extended state and the shortened state by controlling the flow of fluid substances into or out of the bellows 221; in the extended state, the bellows 221 drives the adhesive bag 232 to extend out of the accommodating chamber 251 along the extending direction of the spacer 25; in the shortened state, the bellows 221 brings the adhesive bag 232 into the receiving chamber 251 in the extending direction of the spacer 25.

In the above-mentioned technical solution, the expansion and contraction capability of the bellows 221 is utilized, so as to achieve the purpose of driving the adhesion capsule 232 in the contracted state to extend out of or into the receiving cavity 251, and as an alternative embodiment, the bellows 221 and the adhesion capsule 232 may have different air supply pipes 211, respectively, to control expansion and contraction of the bellows 221 and expansion of the adhesion capsule 232, respectively, but excessive pipelines may be intertwined during the extending into the digestive tract, resulting in device failure. In order to prevent the above, as shown in fig. 6, a bellows 221 may be selectively provided between the adhesive bladder 232 and the air supply tube 211 connected thereto, and in order to prevent the adhesive bladder 232 from being inflated before the bellows 221 extends the adhesive bladder 232 out of the receiving chamber 251, a throttle plate 222 is provided at the junction of the bellows 221 and the adhesive bladder 232, and a through hole is provided in the throttle plate 222 to allow the fluid substance to slowly pass therethrough, so that the fluid substance preferentially fills the space in the bellows 221 when the adhesive bladder 232 is driven to sample, thereby allowing the bellows 221 to elongate before the adhesive bladder 232 is inflated and pushing the adhesive bladder 232 to extend out of the receiving chamber 251, as shown in fig. 5. When the sampled adhesive bag 232 is accommodated in the accommodating chamber 251, the end of the exhaust pipe 212 is positioned in the adhesive bag 232, so that the fluid substance in the corrugated hose 221 is discharged only after the fluid substance in the adhesive bag 232 is substantially discharged, and at this time, the corrugated hose 221 is converted to a shortened state and drives the adhesive bag 232 to enter the accommodating chamber 251.

In addition, the throttle plate 222 may be replaced by a structure capable of breaking under a certain pressure, such as a pressure membrane, so that the bellows 221 and the adhesive bag 232 are not connected before the set pressure is reached, and the fluid substance cannot enter the adhesive bag 232 at this time, only the bellows 221 is extended to the longest position, after the state shown in fig. 5 is reached, the pressure in the bellows 221 continues to increase, and after the set pressure of the pressure membrane is reached, the pressure membrane breaks, and at this time, the fluid substance can enter the first cavity of the adhesive bag 232.

Because the sampled sample has flexibility and fluidity, in order to further prevent loss of the sample, as shown in fig. 4, 5, 6 and 8, the adhesion assembly 20 further includes a blocking unit 24, the blocking unit 24 including a blocking bladder 241 and a check valve 242, the blocking bladder 241 being of a bladder-like structure and being provided with a third opening, the third opening being connected to a second opening 2324 of the adhesion bladder 232 remote from the gas supply tube 211, the check valve 242 being provided at the third opening, the check valve 242 being provided to allow one-way flow of the fluid substance into the blocking bladder 241; the blocking balloon 241 includes a first state in which there is no fluid substance in the blocking balloon 241 and is contracted inward, and a second state in which the blocking balloon 241 is in an expanded state by the driving of the fluid substance, the blocking balloon 241 in the second state is in a spherical shape, and the diameter of the blocking balloon 241 is larger than the inner diameter of the spacer 25.

For the arrangement of the occlusion balloon 241, in its second state, its second lumen 2411 is filled with fluid material, now having a diameter greater than the inner diameter of the spacer 25, and the occlusion balloon 241 can occlude the opening of the receiving lumen 251 into the alimentary canal after the adhesive balloon 232 has entered the receiving lumen 251. When the adhesive balloon 232 is transitioned to the inflated state, fluid material may flow through the check valve 242 into the second lumen 2411 of the occlusion balloon 241, but since the fluid material within the adhesive balloon 232 is expelled as it transitions to the deflated state, the occlusion balloon 241 is transitioned from the second state to the first state in order to prevent the fluid material from being expelled therewith, the check valve 242 is provided such that fluid material cannot be expelled from the second lumen 2411 to the first lumen 23211, and thus the occlusion balloon 241 is capable of maintaining the second state even if the fluid material of the first lumen 23211 is exhausted. The blocking pouch 241 is only required to block the receiving cavity 251, and the diameter of the blocking pouch 241 in the second state is only required to be slightly larger than the inner diameter of the spacer 25 in order to avoid the influence of the blocking pouch 241 when the sample is withdrawn from the digestive tract.

As an alternative embodiment, as shown in fig. 6, 7 and 8, the adhesion assembly 20 further includes a support ring 231, the support ring 231 is disposed at the first opening 2323 and the second opening 2324 of the adhesion capsule 232, the support ring 231 includes an outer ring 2311, an inner ring 2312, and a connection rib 2313 connected between the inner ring 2312 and the outer ring 2311, the outer ring 2311 is sleeved on the outer circumferential surface of the first opening 2323 and fixedly connected to the outer circumferential surface of the adhesion capsule 232, the inner ring 2312 is sleeved on the outer side wall of the exhaust pipe 212 and is adhered to the outer side wall of the exhaust pipe 212, the connection rib 2313 is in a rod shape and is provided with a plurality of connection ribs 2313 passing through the side wall of the adhesion capsule 232, and both ends of the connection rib 2313 are respectively connected with the inner ring 2312 and the outer ring 2311, and the connection rib 2313 passes through the position of the adhesion capsule 232 to be sealed.

Since both the adhesive balloon 232 and the blocking balloon 241 are made of flexible materials, if the length in the axial direction is too long, the sampling operation is not easy to perform due to lack of toughness. Through the supporting ring 231 that sets up for the junction of adhesion capsule 232 and other parts can all have certain toughness, and these junctions are elastic material preparation, and the outer ring body 2311 of supporting ring 231 and the lateral wall fixed connection of adhesion capsule 232, make between adhesion capsule 232 and the supporting ring 231 do not have relative movement, and the junction can have certain toughness, does not lead to being difficult to control because the structure is too soft. Meanwhile, the space between the inner ring 2312 and the outer ring 2311 having the interval can allow the fluid substance to flow therethrough, so that dead zones are prevented from being formed at the joints due to excessive bending of the joints, and the flow of the fluid substance is blocked. In addition, as shown in fig. 7 and 8, the outer ring 2311 may have a certain width, two support rings 231 may be provided at the connection between the two adhesive pockets 232, and the interval between the two support rings 231 is not large, and when the two adhesive pockets 232 are axially deflected, the edges of the two support rings 231 may come into contact, thereby limiting further bending of the two adhesive pockets 232.

The inner ring 2312 is attached to the outer sidewall of the exhaust pipe 212, and as shown in fig. 6 and 7, the exhaust pipe 212 sequentially passes through the inner rings 2312, so that a certain supporting effect can be generated on the exhaust pipe 212, and as the exhaust pipe 212 is only used for supplying fluid substances, the exhaust pipe 212 is only required to have a certain flexibility in material selection, so that the exhaust pipe can conform to bending of the digestive tract, and the toughness of the material can be higher than that of the adhesive sac 232 and the blocking sac 241, so that the exhaust pipe 212 can also serve as a framework to prevent the positions of the first opening 2323 and the second opening 2324 of the adhesive sac 232 from being excessively bent.

The third aspect of the present invention also provides a device for sampling a mucus in a lumen, as shown in fig. 10, comprising: the hose assembly 10, the monitoring assembly 30 and the adhesive assembly 20 according to any one of the second aspect of the present application, wherein the hose assembly 10 comprises a probe unit 12 and an extension pipe 11 which are sequentially connected, the probe unit 12 comprises a base 121, the base 121 is columnar, a plurality of mounting holes penetrating the base 121 along the axial direction are arranged, and the plurality of mounting holes are arranged at intervals along the circumferential direction of the base 121; the monitoring assembly 30 is used for monitoring the state of the adhesion assembly 20; the adhesion assembly 20 and the monitoring assembly 30 are disposed through the extension pipe 11 and through different mounting holes, respectively.

The hose assembly 10 can be used as a carrier for carrying other components in the device, wherein, because the digestive tract is of a long and narrow structure, a plurality of components in the device need to have long connecting wires and connecting pipes in order to extend into the affected part, and the extending pipe 11 can wrap the connecting wires and the connecting pipes therein, so that the connecting wires and the connecting pipes can be prevented from winding when conveniently extending into the digestive tract, and the operation is prevented from being affected. The housing 121, which is connected to the extension tube 11, is adapted to carry end portions of a plurality of components, such as the camera 321, the illumination lamp 311, etc. of the monitoring assembly 30, with different mounting holes, so that the positions of these devices are relatively fixed. Specifically, as shown in fig. 9, the base 121 is provided with a first mounting hole 122, a second mounting hole 123, a third mounting hole 124 and a fourth mounting hole 125, the first mounting hole 122 may be used for providing an illumination lamp 311, the second mounting hole 123 may be used for providing a camera 321, the third mounting hole 124 may be provided with a rinsing head capable of spraying rinsing liquid or liquid medicine, and the fourth mounting hole 125 may be used for mounting the adhesive assembly 20. Wherein the adhesive assembly 20 can be individually withdrawn or fed along the fourth mounting hole 125 and the extension tube 11 to perform sampling of a plurality of sampling points in one sampling operation. For example, after the sampling of the first sampling point is completed, the adhesive assembly 20 is withdrawn, and a new adhesive assembly 20 is replaced, so that the whole cavity mucus sampling device is not required to be withdrawn, and the pain of the patient is reduced.

The detection assembly may include an illumination unit 31 for illumination, as shown in fig. 12, where the illumination unit 31 includes an illumination lamp 311 and a first line 312 connected to the illumination lamp 311, the first line 312 providing power supply to the illumination lamp 311, and illumination light emitted from the illumination lamp 311 may illuminate an operation field. The detection assembly may further comprise an acquisition unit 32, wherein the acquisition unit 32 is configured to transmit the image in real time, and comprises a camera 321 and a second line 322 connected to the camera 321. The camera 321 can collect video data and transmit the video data to the display device through the second line 322, so that medical staff can observe the situation in the digestive tract.

In addition, the cavity mucus sampling device further comprises a control component, wherein the control component comprises an air supply unit 41, an air exhaust unit 42, a liquid supply unit 43, a driving unit 44 and a controller 45; the air supply unit 41 is communicated with the air path unit 21 and supplies fluid substances, the air exhaust unit 42 is communicated with the air path unit 21 and discharges the fluid substances, the liquid supply unit 43 comprises a liquid supply pipe penetrating through the mounting hole and spraying flushing liquid into a human body through the liquid supply pipe, and the driving unit 44 drives the hose assembly 10 to extend into the human body; the controller 45 is used for controlling the actions of the air supply unit 41, the air discharge unit 42, the liquid supply unit 43, the driving unit 44, and the monitoring assembly 30.

Specifically, the air supply unit 41 communicates with the air supply pipe 211 of the adhesive assembly 20, and is capable of supplying a fluid substance thereto, and of controlling the start and end of the supply. The exhaust unit 42 is in communication with the exhaust pipe 212 of the adhesion assembly 20, and the exhaust unit 42 may be provided with a pump and may be capable of withdrawing fluid substances through the exhaust pipe 212. The liquid supply unit 43 can spray the flushing liquid to the alimentary canal through the liquid supply pipe for cleaning the surgical field, instruments, sundries in the alimentary canal, and the like. The drive unit 44 is used to drive the luminal mucus sampling device, and in particular, the flexible tube assembly 10, into or out of the patient along the alimentary tract. As shown in fig. 11, the controller 45 is electrically connected to the air supply unit 41, the air discharge unit 42, the liquid supply unit 43, the driving unit 44, and the monitoring unit 30, and thus can control the operations of the above units, and by controlling the operations of the air discharge unit 42 and the air supply unit 41, the operations of the adhesive assembly 20 can be further controlled.

It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples of implementing the disclosure, and that various changes in form and details may be made therein without departing from the spirit and scope of the disclosure.

Claims (13)

1. An adhesive pouch, the adhesive pouch comprising:

an elastic bag, wherein the elastic bag comprises an elastic bag wall with elasticity and a first inner cavity wrapped in the elastic bag wall;

an adhesive part which is sheet-shaped and made of a material having ductility and is used for adhering a luminal mucus sample; the adhesion part is adhered to the peripheral wall of the elastic bag and is detachably connected with the elastic bag;

the adhesive bag comprises a contracted state and an expanded state, and in the contracted state, the elastic bag is of a tubular structure with a first opening at one end, wherein the first opening is used for filling or discharging fluid substances into or out of the first inner cavity;

in the expansion state, the elastic bag is spherical or ellipsoidal, and fluid substances are controlled to be filled into or discharged from the first inner cavity, so that the elastic bag is driven to be switched between the expansion state and the contraction state, and meanwhile, the adhesion part is driven to deform.

2. An adhesive pouch according to claim 1, wherein,

the adhesion parts are arranged in a plurality and are respectively arranged at intervals along the circumferential direction of the elastic bag.

3. An adhesive pouch according to claim 1, wherein,

The adhesive part is of a strip-shaped sheet structure and extends along the axial direction of the elastic bag, and a space is arranged between the end part of the adhesive part in the length direction and the end part of the elastic bag in the axial direction.

4. An adhesive assembly, the adhesive assembly comprising:

an adhesion unit and a gas path unit; the adhesive unit comprising the adhesive pouch of any one of the preceding claims 1-3; the gas path unit is in sealing connection with the first opening and enables fluid substances to be filled into or discharged out of the first inner cavity through the first opening.

5. An adhesive assembly according to claim 4, wherein,

the adhesion unit comprises a plurality of adhesion bags, the elastic bags of the adhesion bags are sequentially connected, and the first inner cavities are mutually communicated; the elastic bag is further provided with a second opening, the second opening is arranged at one end, far away from the first opening, of the elastic bag, and the first opening of one elastic bag of two adjacent elastic bags is communicated with the second opening of the other elastic bag.

6. An adhesive assembly according to claim 5, wherein,

The adhesive unit comprises two adhesive capsules;

the air path unit comprises an air supply pipe and an exhaust pipe, wherein the first end of the air supply pipe is communicated with the first opening of one of the adhesive bags;

the first end of the exhaust pipe extends into the first inner cavities of the two adhesive bags through the first end of the air supply pipe and extends to the second opening of the adhesive bag far away from the air supply pipe.

7. An adhesive assembly according to claim 6, wherein,

the air supply pipe is sleeved with the outer side of the exhaust pipe, and a gap is arranged between the inner side wall of the air supply pipe and the outer side wall of the exhaust pipe.

8. An adhesive assembly according to claim 7, wherein,

the adhesive assembly further comprises a tubular isolation sleeve, the isolation sleeve is arranged on the outer side of the air supply pipe, a gap is formed between the inner side wall of the isolation sleeve and the outer side wall of the air supply pipe, the isolation sleeve is provided with a containing cavity for containing a plurality of adhesive bags in the contracted state, and the adhesive bags in the contracted state are arranged to extend out of or enter the containing cavity along the extending direction of the isolation sleeve.

9. An adhesive assembly according to claim 8, wherein,

the adhesion assembly further comprises a telescopic unit, the telescopic unit comprises a corrugated hose and a throttle plate, wherein the corrugated hose can be lengthened or shortened along the axial direction, one end of the corrugated hose is communicated with the air supply pipe, the other end of the corrugated hose is communicated with the first opening of the adhesion bag close to the air supply pipe, and the exhaust pipe penetrates through the corrugated hose along the axial direction;

the throttle plate is arranged at the joint of the corrugated hose and the adhesive bag, and is provided with a plurality of through holes, wherein the sum of the sectional areas of the through holes is 5% -10% of the diameter of the air supply pipe;

the bellows having an extended state and a shortened state, the bellows being driven to switch between the extended state and the shortened state by controlling the flow of fluid material into or out of the bellows;

in the extension state, the corrugated hose drives the adhesive bag to extend out of the accommodating cavity along the extension direction of the isolation sleeve;

in the shortened state, the corrugated hose drives the adhesive bag to enter the accommodating cavity along the extending direction of the isolation sleeve.

10. An adhesive assembly according to claim 9, wherein,

the adhesion assembly further comprises a blocking unit, the blocking unit comprises a blocking bag and a one-way valve, the blocking bag is of a bag-shaped structure and is provided with a third opening, the third opening is connected with the second opening of the adhesion bag far away from the air supply pipe, the one-way valve is arranged at the third opening, and the one-way valve is arranged to enable fluid substances to flow into the blocking bag in a one-way mode;

the blocking bag comprises a first state and a second state, wherein in the first state, no fluid substance exists in the blocking bag and contracts inwards, in the second state, the blocking bag is in an expanded state under the drive of flowing substances, the blocking bag in the second state is in a spherical shape, and the diameter of the blocking bag is larger than the inner diameter of the isolation sleeve.

11. An adhesive assembly according to claim 6, wherein,

the adhesion assembly further comprises a support ring, the support ring is arranged at the first opening and the second opening of the adhesion bag, the support ring comprises an outer ring body, an inner ring body and connecting ribs connected between the inner ring body and the outer ring body, the outer ring body is sleeved on the outer peripheral surface of the first opening and fixedly connected to the outer peripheral surface of the adhesion bag, the inner ring body is sleeved on the outer side wall of the exhaust pipe and is attached to the outer side wall of the exhaust pipe, the connecting ribs are in a stick shape and are arranged in a plurality of, pass through the side wall of the adhesion bag, the two ends of the connecting ribs are connected with the inner ring body and the outer ring body respectively, and the connecting ribs pass through the position of the adhesion bag and are sealed.

12. A luminal mucus sampling device, wherein the luminal mucus sampling device comprises:

the hose assembly comprises a probe unit and an extension pipe which are sequentially connected, wherein the probe unit comprises a seat body, the seat body is columnar and is provided with a plurality of mounting holes penetrating through the seat body along the axial direction, and the plurality of mounting holes are arranged at intervals along the circumferential direction of the seat body;

the monitoring component is used for monitoring the state of the adhesion component;

the adhesive assembly and the monitoring assembly are disposed through the extension tube and through different ones of the mounting holes, respectively.

13. The device of claim 12, wherein,

the cavity mucus sampling device further comprises a control component, wherein the control component comprises an air supply unit, an air exhaust unit, a liquid supply unit, a driving unit and a controller;

the air supply unit is communicated with the air path unit and supplies fluid substances, the air exhaust unit is communicated with the air path unit and discharges the fluid substances, the liquid supply unit comprises a liquid supply pipe penetrating through the mounting hole and spraying flushing liquid into a human body through the liquid supply pipe, and the driving unit drives the hose assembly to extend into the human body;

The controller is used for controlling actions of the air supply unit, the air exhaust unit, the liquid supply unit, the driving unit and the monitoring component.