CN117838974A - Artificial in-vitro pancreas - Google Patents

Abstract

The invention discloses an artificial external pancreas, which comprises a bottom plate, an indwelling assembly, a medicine box and a host assembly; the main machine component comprises a main control board, the main control board is electrically connected with the monitoring probe so as to receive human physiological parameters transmitted by the monitoring probe, and the main control board is used for controlling the medicine box to output medicine liquid according to the monitoring result of the human physiological parameters. The artificial external pancreas of the invention realizes the integration of blood sugar monitoring and insulin injection, simplifies the puncture process, reduces the pain and infection risk of patients, has compact structural design, is convenient to carry and can be repeatedly used for a long time, provides the capability of continuously monitoring blood sugar and accurately delivering insulin liquid medicine, is easy to maintain and replace, and increases the practicability and economic benefit of products.

Description

Artificial in-vitro pancreas

Technical Field

The invention relates to the field of medical appliances, in particular to an artificial in-vitro pancreas.

Background

Diabetes is a worldwide epidemic chronic disease, continuous and accurate blood glucose management is critical to avoiding complications, and in modern treatment schemes, an artificial in vitro pancreas is used as an advanced technical tool, aiming at simulating the functions of human in vivo pancreas and realizing more accurate blood glucose control.

Existing artificial in vitro pancreas techniques typically employ split designs, including the following major devices:

continuous blood glucose monitor: this device continuously monitors the blood glucose level of diabetics by subcutaneously implanting sensors, while providing real-time blood glucose readings, because it is a stand-alone device, it requires a separate puncture; and

insulin pump: insulin pumps are used to deliver insulin to diabetics by another puncture, and the insulin pump may manually or automatically adjust the dosage of insulin delivered based on blood glucose readings.

Some of the core problems and challenges of the prior art include:

first, due to the split design, the continuous blood glucose monitor and insulin pump must be configured and managed separately. This adds complexity to the overall system and can be confusing to the patient or healthcare worker;

(two) the use of two separate devices means that the patient must undergo multiple punctures, which may lead to an increased risk of discomfort and skin damage, and an increased risk of infection;

third, because the monitoring and pumping functions are separate, the patient or healthcare worker may need to spend more time and effort manually coordinating these devices to ensure proper operation of the overall system;

(IV) the overall design of the existing system may limit the freedom of movement and convenience of daily life for the patient because of the need to manage and maintain multiple independent devices;

fifth, the patient may feel more discomfort and pain due to the multiple punctures and more complex procedures required.

Disclosure of Invention

In order to solve the problems, the invention provides the artificial external pancreas, integrates blood glucose monitoring and insulin injection, has a simple overall structure, realizes miniaturization of the artificial external pancreas, can realize two functions at the same time by one puncture, is convenient to use, facilitates life of patients, and effectively solves the defects in the prior art.

The invention is realized by the following technical scheme: an artificial in vitro pancreas, characterized in that: comprises a bottom plate, an indwelling component, a medicine box and a host component;

the indwelling assembly is arranged on the bottom plate and comprises an indwelling soft needle with an injection channel and a monitoring probe;

the medicine box and the host assembly are mutually assembled and integrally arranged on the bottom plate, and a medicine outlet of the medicine box is communicated with the injection channel;

the main machine assembly comprises a main control board, the main control board is electrically connected with the monitoring probe, so as to receive the physiological parameters of the human body transmitted by the monitoring probe, and the main control board is used for controlling the medicine chest to output medicine liquid according to the monitoring result of the physiological parameters of the human body.

As an optimal technical scheme, the physiological parameter of the human body transmitted by the monitoring probe is the blood sugar level, and the medicine box output medicine liquid is insulin medicine liquid.

As the preferable technical scheme, be equipped with on the bottom plate with the medical kit with the installation cell body of the whole matching of host computer subassembly, the medical kit with the whole embedding of host computer subassembly is installed in the installation cell body, just the bottom of medical kit have with keep somewhere the mounting hole of subassembly assembly.

As a preferable technical scheme, at least one side of the mounting groove body is provided with a first buckle, and the side end of the main machine component and/or the medicine chest is provided with a first clamping groove correspondingly adapted to the first buckle;

or at least one side of the mounting groove body is provided with a first clamping groove, and a first buckle correspondingly adapted to the first clamping groove is formed at the side end of the main machine component and/or the medicine chest.

As the preferable technical scheme, the bottom of bottom plate is provided with the second buckle, the bottom of host computer subassembly is equipped with the slide hole the outside of host computer subassembly still slidable mounting has the slide fastener, wherein, the top of second buckle is hook-shaped to can pass the slide hole with the slide fastener forms hook-shaped cooperation, and still is provided with the elastic component, through the elastic component can with the slide fastener with second buckle locking or release the second buckle.

As the preferable technical scheme, the medicine chest is provided with a medicine injection needle, a medicine outlet of the medicine chest is communicated with the remaining soft needle through the medicine injection needle, and the monitoring probe is arranged on the inner side of the remaining soft needle.

As an optimized technical scheme, the medicine chest is used for being connected with the main machine component, one side end of the medicine chest is provided with a connecting hole, and a connecting terminal electrically connected with the main control board can penetrate through the connecting hole and is electrically connected with a contact of the monitoring probe.

As a preferable technical scheme, the host assembly further comprises an injector connected with the piston inside the medicine chest, and the main control board is electrically connected with the injector;

the host assembly further includes a battery pack for providing electrical power.

As a preferable technical scheme, a fixing patch is arranged at the bottom of the bottom plate.

As a preferred technical solution, the artificial extracorporeal pancreas further comprises a needle assisting assembly, wherein the needle assisting assembly is used for being connected with the indwelling assembly, so that the indwelling assembly is installed on the bottom plate and simultaneously performs a puncturing operation.

The beneficial effects of the invention are as follows:

1. the invention integrates blood glucose monitoring and insulin injection into an integrated design, reduces the number of devices and the complexity of use, and improves the convenience of patients;

2. the subcutaneous puncture is completed through the indwelling assembly, and two functions of blood glucose monitoring and insulin injection can be realized at the same time through one puncture, so that the pain and discomfort of a patient are relieved, and the risk of infection is reduced;

3. compared with the traditional split design, the integrated structure of the invention is more compact, realizes the miniaturization of the artificial external pancreas, and is convenient to carry and use;

4. because the parts of the invention are designed well, the long-term repeated use of the equipment can be ensured, the service life is prolonged, the use cost is reduced, the bottom plate, the medicine box, the main machine component and other multi-component buckle clamping grooves are buckled and fixed, and the stability and the reliability of the whole equipment are enhanced;

5. the bottom plate, the indwelling assembly, the medicine box and the main machine assembly are accurately connected, so that continuous blood sugar monitoring and accurate insulin medicine liquid conveying are realized, and a more humanized treatment scheme is provided; the vibration motor and the status indicator lamps with different indication colors and indication modes realize user-friendly indication of working status; the bottom of the bottom plate is stuck with a fixed patch, so that the whole equipment is ensured to be stably stuck on the skin surface of a human body, and the risks of side effects and complications are reduced;

6. the invention conveniently completes one-time subcutaneous puncture operation and simultaneously realizes two functions through the modularized designs of the bottom plate, the indwelling assembly, the needle assisting assembly and the like, has simple needle assisting operation and is suitable for the treatment requirement of patients;

7. the detachable design of the main machine component, the medicine chest and the like is convenient for equipment maintenance and replacement, increases the practicability and economic benefit of products, can be reused for a long time, is economical and environment-friendly, and meets the long-term use requirement of patients.

Drawings

In order to more clearly illustrate the embodiments of the invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, it being obvious that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of the structure of an artificial exocrine pancreas;

FIG. 2 is a schematic diagram of another view of an artificial exocrine pancreas;

FIG. 3 is an exploded view of an artificial exocrine pancreas;

FIG. 4 is an exploded view of another view of the artificial exocrine pancreas;

FIG. 5 is a cross-sectional view of an artificial exocrine pancreas;

FIG. 6 is a bottom view of a portion of the structure of an artificial exocrine pancreas;

FIG. 7 is a schematic structural view of another portion of an artificial exocrine pancreas;

FIG. 8 is a schematic structural view of a host assembly of an artificial exocrine pancreas;

FIG. 9 is an exploded view of the host assembly of the artificial exocrine pancreas;

FIG. 10 is a schematic view of a portion of the interior of a host assembly of an artificial exocrine pancreas;

FIG. 11 is a schematic view of the structure of the needle assist assembly, the indwelling assembly and the base plate of the artificial exocrine pancreas;

reference numerals illustrate:

1. a bottom plate; 2. a retention assembly; 3. a needle assist assembly; 4. a medicine box; 5. a host component; 6. a slide fastener; 11. a first buckle; 12. a second buckle; 21. a soft needle is kept; 22. monitoring a probe; 41. a drug injection needle; 42. a mounting hole; 51. a main control board; 52. a syringe; 53. a battery pack; 54. a face shell; 55. a bottom case; 56. a first clamping groove; 57. a slide hole; 58. a vibration motor; 511. and a connection terminal.

Detailed Description

All of the features disclosed in this specification, or all of the steps in a method or process disclosed, may be combined in any combination, except for mutually exclusive features and/or steps.

Any feature disclosed in this specification (including any accompanying claims, abstract and drawings), may be replaced by alternative features serving the same, equivalent or similar purpose, unless expressly stated otherwise. That is, each feature is one example only of a generic series of equivalent or similar features, unless expressly stated otherwise.

As shown in fig. 1, 3, 4 and 11, an artificial exocrine pancreas of the present invention comprises a base plate 1, an indwelling assembly 2, a medicine box 4 and a host assembly 5;

the bottom plate 1 is used as a bearing carrier, one side of the bottom plate is used for being attached to the skin of a patient, and the other side of the bottom plate is used for being provided with the indwelling assembly 2, the medicine box 4 and the host assembly 5;

the retaining component 2 is arranged on the bottom plate 1 and completes subcutaneous puncture during monitoring injection, the retaining component 2 can be fixedly arranged on the mounting position by arranging a mounting position on the bottom plate 1, the retaining component 2 can be clamped or in other connection modes, the retaining component 2 can be firmly fixed, the retaining component 2 comprises a retaining soft needle 21 with an injection channel and a monitoring probe 22, the monitoring probe 22 is used for monitoring physiological parameters of a human body, liquid medicine infusion is realized through the injection channel, the monitoring probe 22 is positioned in the retaining soft needle 21, the tip of the retaining soft needle 21 extends out of the lower end face of the bottom plate 1, the monitoring probe 22 and the retaining soft needle 21 are always retained under the skin of a patient so as to measure physiological parameters of the human body in real time, and the corresponding infusion liquid medicine of the human body is promoted, the monitoring injection effect is improved, and the skin is punctured through the arrangement of the tip so as to complete the implantation process;

the medicine box 4 is internally provided with medicine liquid for supplying injectable medicine liquid to a patient during monitoring injection, the main machine component 5 is used for integrally controlling an artificial external pancreas, the medicine box 4 is mutually assembled with the main machine component 5, the main machine component 5 and the medicine box 4 are in buckling connection during assembly, a silica gel sleeve is arranged at the buckling position, the medicine box 4 and the main machine component 5 are of L-shaped structures, then the medicine box 4 and the main machine component 5 are integrally installed on the bottom plate 1, and a medicine outlet of the medicine box 4 is communicated with an injection channel, so that the medicine liquid in the medicine box 4 is conveyed into blood of the patient through the injection channel, long-term real-time human physiological parameter monitoring and medicine liquid injection can be realized, the medicine box 4 and the indwelling component 2 are well sealed, and continuity and stability in the medicine liquid transmission process are ensured;

the host assembly 5 comprises a main control board 51, the main control board 51 is electrically connected with the monitoring probe 22 to receive the human physiological parameters transmitted by the monitoring probe 22, the main control board 51 is used for controlling the medicine box 4 to output medicine liquid according to the monitoring result of the human physiological parameters, the monitoring probe 22 is contacted with the blood of a patient in real time along with the indwelling soft needle 21 so as to achieve real-time monitoring of the human physiological parameters, the whole monitoring process is intermittent, the interval value can be set manually, monitoring information is fed back to the main control board 51 in real time, after the main control board 51 receives the monitoring information, the main control board 51 is used for making medicine liquid injection instructions, namely, according to the monitoring result of the human physiological parameters, the main control board 51 is used for obtaining the corresponding medicine liquid injection mode, injection dosage and the like, and controlling the piston in the medicine box 4 to move so as to realize the timed and quantitative medicine liquid infusion;

in addition, the main control board 51 can be added with a wireless communication module to allow remote medical monitoring, and a patient, doctor or nursing staff can remotely access and control the artificial external pancreas, so that chronic disease management is more convenient, and a user interface comprising a touch screen or a matched mobile phone application program can be independently designed, so that the patient, doctor or nursing staff can monitor and adjust settings more easily, and meanwhile, historical data analysis and trend prediction can be provided.

In this embodiment, the physiological parameter of the human body is blood glucose level, the liquid medicine is insulin liquid medicine, that is, the physiological parameter of the human body transmitted by the monitoring probe 22 is blood glucose level, the liquid medicine output by the medicine chest 4 is insulin liquid medicine, the blood of the patient can be in real-time contact with the monitoring probe 22, so as to realize real-time monitoring of blood glucose, the monitoring probe 22 is electrically connected with the main control board 51, and is used for transmitting monitoring information to the main control board 51, after receiving the monitoring information, the main control board 51 performs control of insulin liquid medicine injection according to the blood glucose level fed back, so as to obtain insulin liquid medicine injection dosage corresponding to the value of the monitoring result, and achieve the purposes of real-time monitoring and real-time regulation.

In this embodiment, the whole medicine box 4 and the main machine component 5 are fixedly installed on the bottom plate 1 through the matching of the multiple groups of fastening slots, and through the design of the multiple groups of fastening slots, the whole medicine box 4 and the whole main machine component 5 can be firmly connected with the bottom plate 1, so that looseness or falling off can not occur during long-time wearing or activity, the whole medicine box 4 and the whole main machine component 5 can be easily installed and removed, special tools or complex procedures are not needed, and additional connecting materials such as screws or glue are not needed, so that the medicine box 4 and the main machine component 5 are very convenient for the connection and use of patients, fault points are reduced, the medicine box 4 and the main machine component 5 can be repeatedly used for a long time, and the use cost is reduced;

specifically, in this embodiment, as shown in fig. 1 and fig. 2, the base plate 1 is provided with a mounting groove body integrally matched with the medicine box 4 and the host component 5, the medicine box 4 and the host component 5 are integrally embedded and mounted in the mounting groove body, as shown in fig. 4, the bottom of the medicine box 4 is provided with a mounting hole 42 assembled with the retaining component 2, as shown in fig. 3 and fig. 4, at least one side of the mounting groove body is provided with a first buckle 11, the side end of the host component 5 is provided with a first buckle 56 correspondingly matched with the first buckle 11, or in another embodiment, at least one side of the mounting groove body is provided with a first buckle 56, the side end of the host component 5 is provided with a first buckle 11 correspondingly matched with the first buckle 56, of course, the first buckle 56 or the first buckle 11 can also be provided or formed at the side end of the medicine box 4, the bottom end of the base plate 1 is provided with a second buckle 12, the bottom of the host assembly 5 is provided with a slide hole 57, the second buckle 12 is formed at the bottom end of the bottom plate 1 corresponding to the position of the slide hole 57 at the bottom of the host assembly 5, the slide buckle 6 is slidably arranged outside the host assembly 5, wherein the top end of the second buckle 12 is hooked, the end can pass through the slide hole 57 to form hooked fit with the slide buckle 6, an elastic piece is further arranged between the slide buckle 6 and the equipment main body, the second buckle 12 can be locked or released with the slide buckle 6 through the elastic piece, as shown in fig. 6, the safety of connection is improved through the fit of the second buckle 12 with the slide buckle 6 with the hooked top end and the locking effect of the elastic piece, the risk of connection loosening or falling caused by accidental collision or pulling is reduced, the buckle fixing mode is not limited to the buckle fixing above, more buckles can be adopted, the number of the buckles can be adjusted according to actual needs, the slide fastener 6 can be in a key-type structure and is arranged at a conspicuous position of an artificial external pancreas, so that the slide fastener is convenient to disassemble and assemble, anti-skid textures can be arranged outside the slide fastener 6, friction force during contact is increased, slipping is prevented, and better operation is realized; during installation, the first clamping groove 56 at the side end of the host component 5 is aligned with the first clamping buckle 11 at the side end of the bottom plate 1 and inserted, the sliding hole 57 at the bottom of the host component 5 is aligned with the second clamping buckle 12 and inserted into the medicine box 4 and the host component 5, the hook positions of the sliding buckle 6 and the second clamping buckle 12 are combined to form hook-shaped matched connection, so that the medicine box 4 and the host component 5 are integrally installed relative to the bottom plate 1, during disassembly, the sliding buckle 6 is pushed to separate the hook positions of the sliding buckle 6 from the second clamping buckle 12, and then the medicine box 4 and the host component 5 are taken out from the direction deviating from the first clamping buckle 11, so that the medicine box 4 and the host component 5 are integrally disassembled relative to the bottom plate 1;

further, in this embodiment, two sets of the first buckle 11 and the first slot 56 are disposed correspondingly, two first buckles 11 are disposed on one side of the base plate 1, two first slots 56 are disposed on one side of the host assembly 5, and two first buckles 11 on the base plate 1 are aligned with two first slots 56 on the host assembly 5 to be inserted respectively for positioning and mounting.

In the embodiment, the medicine box 4 is provided with a medicine injection needle 41, a medicine outlet of the medicine box 4 is communicated with the indwelling soft needle 21 through the medicine injection needle 41, and the monitoring probe 22 is arranged at the inner side of the indwelling soft needle 21; the medicine box 4 is used for being connected with the host assembly 5, one side end of the medicine box is provided with a connecting hole, and a connecting terminal 511 electrically connected with the main control board 51 can pass through the connecting hole and is electrically connected with a contact of the monitoring probe 22, so that continuous monitoring of blood sugar and accurate insulin medicine liquid delivery are realized; because the insulin liquid medicine in the medicine chest 4 flows into the injection channel of the soft indwelling needle 21 through the medicine injection needle 41, and the soft indwelling needle 21 is always reserved under the skin of the patient after being implanted into the skin of the patient, the insulin liquid medicine can be conveyed into the blood of the patient, the purpose of quick injection is achieved, and long-term real-time insulin liquid medicine injection is realized; the monitoring probe 22 can continuously conduct electricity monitoring, long-term real-time blood glucose level monitoring is achieved, the connecting terminal 511 is directly connected with the contact of the monitoring probe 22 through the connecting hole on the medicine chest 4, a traditional wiring structure is omitted, the artificial external pancreas is smaller and attractive, the reduced wiring can reduce fault risks, the reliability of the artificial external pancreas is improved, the integrated design simplifies interaction among components, when the medicine chest 4, the indwelling component 2 or other components are required to be replaced or maintained, operation becomes simpler and more visual, complex connection is not needed, the connecting terminal 511 electrically connected with the main control board 51 is achieved through the connecting hole, the contact of the monitoring probe 22 is connected with the whole small design, the artificial external pancreas is attractive, comfort of a patient can be increased, the reduced volume and the simpler appearance can lighten psychological burden of the patient, the artificial external pancreas is more willing to wear for a long time, and in addition, the structure of the connecting hole and the contact can allow greater compatibility and expandability, and the medicine chest 4 or other components with different types and sizes can be matched for use.

In this embodiment, the monitoring probe 22 monitors according to a set frequency value by using a glucose sensor, receives an electrical signal (voltage) generated by an electrochemical reaction, and then reads and stores a blood glucose value converted from the electrical signal;

specifically, in this embodiment, the monitoring probe 22 is implanted into the skin of the patient, and the enzyme carried on the monitoring probe 22 can electrochemically react with glucose in the blood of the patient to generate an electrical signal (voltage), so as to measure the sugar content in the blood of the patient, i.e. the blood glucose level, and in the period of monitoring the blood glucose level in the patient in real time, the electrical signal (voltage) is received once every time T, and then the electrical signal (voltage) is converted into the blood glucose level to be read and stored, so as to realize the real-time monitoring of the sugar content in the blood of the patient, i.e. the blood glucose level, wherein T can be 10s, 20s, 30s, etc., and the specific time interval is set according to the severity of the disease of the patient, so that the monitoring probe can be set to have an adjusting function, so that the patient can adjust himself or adjust according to the doctor advice to obtain the optimal detection frequency.

Referring to fig. 8, 9 and 10, in this embodiment, the host assembly 5 includes a face shell 54 and a bottom shell 55, the face shell 54 and the bottom shell 55 are assembled to form an assembly space, the host assembly 5 further includes an injector 52 connected with the piston inside the medicine box 4, the host assembly 5 further includes a battery 53, the main control board 51, the injector 52 and the battery 53 are all installed in the assembly space, the output end of the injector 52 is connected with the piston inside the medicine box 4, when the injector 52 acts, the piston inside the medicine box 4 can be pushed to act, the purpose of insulin medicine liquid delivery is achieved, and the main control board 51 is electrically connected with the injector 52, so that according to the real-time blood glucose monitoring result, the injector 52 is controlled to push the piston to move a distance, thereby controlling the insulin medicine liquid in the medicine box 4 to enter into the blood of a patient at regular time and quantitatively, the battery 53 is used for providing electric energy, the battery 53 is arranged on the bottom shell 55 side by side with the injector 52, the main control board 51 is arranged above the injector 52 and the battery 53, the main control board 51, the injector 52 and the battery 53 are integrated in the assembly space, the main control board 52, the injector 52 and the battery 53 is arranged in the battery 53, the main control board 52 and the injector 52 and the battery 53 are arranged in the battery 53.

Referring to fig. 10, further, in this embodiment, the host assembly 5 further includes a vibration motor 58 and a status indicator lamp, the vibration motor 58 is mounted on the bottom shell 55 for vibration prompting, the status indicator lamp is mounted on the main control board 51, the status indicator lamp has different indication colors and indication modes for working status indication, the position of the face shell 54 corresponding to the status indicator lamp is set to be transparent or semitransparent, the vibration motor 58 allows the user to understand through tactile feedback, at the same time, the user can obtain visual feedback through setting the status indicator lamp with different colors and flashing modes, and the transparent or semitransparent setting on the face shell 54 enables the status indicator lamp to be visible, the combination of the two ensures wider accessibility, when abnormality occurs, the vibration 8 vibrates and the status indicator lamp lights up, thereby realizing alarm prompting to rapidly inform the user, and increasing safety.

Referring to fig. 2, in this embodiment, a fixing patch is disposed at the bottom of the bottom plate 1, wherein the fixing patch may be a medical adhesive tape, the bottom plate 1 is attached to the skin surface of a patient through the medical adhesive tape, and the bottom is provided with the fixing patch, so that the bottom plate 1 can be directly attached to the skin without using other parts for attaching, the tight attachment between the bottom plate 1 and the skin of the patient ensures the stability and the position accuracy of the artificial pancreas outside the patient, the displacement caused by movement or daily activity is avoided, the reliability of wearing for a long time is ensured, and the medical adhesive tape is generally friendly to the skin, the risk of allergy or skin irritation is reduced, and a comfortable wearing experience is provided for the patient.

As shown in fig. 11, in this embodiment, the artificial extracorporeal pancreas further includes a needle assisting component 3, the needle assisting component 3 is used for being connected with the indwelling component 2, so that the indwelling component 2 is installed on the bottom plate 1 and completes the puncturing operation at the same time, the needle assisting component 3 is provided to accurately control the puncturing depth and angle of the indwelling soft needle 21, so that the indwelling soft needle 21 can reach the required subcutaneous position more accurately, the puncturing error is reduced, then, by assisting force application of the needle assisting component 3, the indwelling soft needle 21 can be implanted into the skin of a patient more stably, sudden impact and stimulation to the skin are reduced, thereby relieving pain feeling in the puncturing process, meanwhile, the indwelling component 2 is firmly connected with the bottom plate 1, the needle assisting component 3 is withdrawn after the puncturing is completed, the monitoring probe 22 and the indwelling soft needle 21 are always reserved under the skin of the patient, in addition, the needle assisting component 3 can enable the subcutaneous puncturing operation to be simpler and more visual, the patient can operate by himself or medical staff to operate more conveniently, complexity and difficulty of operation are reduced, stable support and guide are provided, the puncturing position offset caused by the operation error is reduced, the potential risk caused by the puncturing error is reduced, and finally, the risk caused by the puncturing error is reduced, and the needle assisting component 2 is connected with the bottom plate 1 rapidly and the puncturing operation can be more effectively shortened, and the puncturing process is saved.

In this embodiment, the artificial exopancreas further comprises a drug feeder for pumping the insulin liquid medicine in the original drug bottle into the drug box 4, so that the drug box 4 is filled with the insulin liquid medicine, the insulin liquid medicine can be supplied before the artificial exopancreas is used or when the insulin liquid medicine in the drug box 4 is used up, the drug feeder is designed for transferring the insulin liquid medicine from the original drug bottle into the drug box 4 of the artificial exopancreas, and after the drug administration is completed, the drug feeder can be temporarily put aside for the next use.

The artificial in vitro pancreas is used as follows:

pumping insulin liquid medicine in the original medicine bottle into the medicine box 4 by using the medicine feeder, and taking down the whole medicine feeder after the completion, wherein the medicine feeder is designed for pumping the insulin liquid medicine in the original medicine bottle into the medicine box 4;

the bottom plate 1 is stuck on the surface of the skin of a patient through the medical adhesive tape, the design of the bottom plate 1 ensures the stable adhesion between the whole equipment and the skin of the patient, and meanwhile, the medical adhesive tape is adopted, so that the risk of skin irritation or allergy is reduced;

the subcutaneous implantation of the indwelling assembly 2 is assisted and completed by using the needle assisting assembly 3, the needle assisting assembly 3 is designed for precisely controlling the puncture depth and angle of the indwelling soft needle 21, ensuring that the indwelling soft needle 21 is correctly implanted into the subcutaneous position of a patient, then the needle assisting assembly 3 is withdrawn, the indwelling assembly 2 is firmly fixed on the bottom plate 1, meanwhile, the monitoring probe 22 and the indwelling soft needle 21 are always reserved under the subcutaneous position of the patient, an injection channel in the indwelling soft needle 21 is used as an infusion channel of insulin liquid medicine, and the monitoring probe 22 is in real time contact with the blood of the patient to continuously monitor the blood sugar level in the blood;

the medical kit 4 with the insulin liquid medicine is stored and the host computer subassembly 5 is fixedly installed with the bottom plate 1, the connecting terminal 511 electrically connected with the main control board 51 is in contact connection with the monitoring probe 22, the main control board 51 receives the blood sugar level transmitted by the monitoring probe 22, the main control board 51 controls the injector 52 to push the piston moving distance inside the medical kit 4 according to the monitoring result of the blood sugar level, the insulin liquid medicine is stored inside the medical kit 4, the medicine outlet of the medical kit 4 is communicated with the remaining soft needle 21, and under the action of internal and external pressure difference, the insulin liquid medicine in the medical kit 4 is controlled to be timely and quantitatively conveyed into the blood of a patient through the injection channel, so that the effective management of the blood sugar is realized.

The whole artificial external pancreas of the invention adopts an intelligent control algorithm to drive an electronic machine, imitates the sensing of normal human body to blood sugar and the secretion function to insulin, the monitoring probe 22 is used for measuring the blood sugar level in the diabetic patient in real time, and the injection mode and the injection dosage of insulin liquid medicine pumped by the injector 52 to the diabetic patient in time are adjusted according to the feedback of the blood sugar level, so that the blood sugar level is controlled within the standard range.

The foregoing is merely illustrative of specific embodiments of the present invention, and the scope of the invention is not limited thereto, but any changes or substitutions that do not undergo the inventive effort should be construed as falling within the scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope defined by the claims.

Claims (10)

1. An artificial in vitro pancreas, characterized in that: comprises a bottom plate (1), an indwelling component (2), a medicine box (4) and a host component (5);

the indwelling assembly (2) is arranged on the bottom plate (1), and the indwelling assembly (2) comprises an indwelling soft needle (21) with an injection channel and a monitoring probe (22);

the medicine chest (4) and the host assembly (5) are mutually assembled and integrally arranged on the bottom plate (1), and a medicine outlet of the medicine chest (4) is communicated with the injection channel;

the main machine assembly (5) comprises a main control board (51), the main control board (51) is electrically connected with the monitoring probe (22) so as to receive the physiological parameters of the human body transmitted by the monitoring probe (22), and the medicine chest (4) is controlled to output medicine liquid through the main control board (51) according to the monitoring result of the physiological parameters of the human body.

2. The artificial in vitro pancreas of claim 1, wherein: the physiological parameter of the human body transmitted by the monitoring probe (22) is the blood sugar level, and the liquid medicine output by the medicine chest (4) is insulin liquid medicine.

3. The artificial in vitro pancreas of claim 1, wherein: the bottom plate (1) is provided with an installation groove body which is integrally matched with the medicine chest (4) and the host component (5), the medicine chest (4) and the host component (5) are integrally embedded and installed in the installation groove body, and the bottom of the medicine chest (4) is provided with an installation hole (42) which is assembled with the retaining component (2).

4. The artificial in vitro pancreas of claim 3, wherein: at least one side of the mounting groove body is provided with a first buckle (11), and a first clamping groove (56) correspondingly matched with the first buckle (11) is formed at the side end of the host assembly (5) and/or the medicine chest (4);

or at least one side of the mounting groove body is provided with a first clamping groove (56), and a first buckle (11) correspondingly matched with the first clamping groove (56) is formed at the side end of the host assembly (5) and/or the medicine chest (4).

5. The artificial in vitro pancreas of claim 4, wherein: the bottom of bottom plate (1) is formed with second buckle (12), the bottom of host computer subassembly (5) is equipped with slide hole (57) the outside of host computer subassembly (5) still slidable mounting has slider (6), wherein, the top of second buckle (12) is hook-shaped to can pass slide hole (57) with slider (6) forms hook-shaped cooperation, and still is provided with the elastic component, can pass through slider (6) with second buckle (12) locking or release second buckle (12).

6. The artificial in vitro pancreas of claim 1, wherein: the medicine box (4) is provided with a medicine injection needle (41), a medicine outlet of the medicine box (4) is communicated with the remaining soft needle (21) through the medicine injection needle (41), and the monitoring probe (22) is arranged at the inner side of the remaining soft needle (21).

7. The artificial in vitro pancreas of claim 1, wherein: the medicine chest (4) is used for being connected with one side end of the host component (5) and is provided with a connecting hole, and a connecting terminal (511) electrically connected with the main control board (51) can penetrate through the connecting hole and is electrically connected with a contact of the monitoring probe (22).

8. The artificial in vitro pancreas of claim 1, wherein: the main machine assembly (5) further comprises an injector (52) connected with the piston inside the medicine chest (4), and the main control board (51) is electrically connected with the injector (52);

the host assembly (5) further comprises a battery pack (53), the battery pack (53) being for providing electrical energy.

9. The artificial in vitro pancreas of claim 1, wherein: the bottom of the bottom plate (1) is provided with a fixing patch.

10. The artificial in vitro pancreas of claim 1, wherein: the artificial extracorporeal pancreas further comprises a needle assisting assembly (3), wherein the needle assisting assembly (3) is used for being connected with the indwelling assembly (2), so that the indwelling assembly (2) is installed on the bottom plate (1) and simultaneously completes puncture operation.