CN117825724A - Control method for sample analyzer and sample analyzer - Google Patents

Abstract

The present application relates to a control method for a sample analyzer and a sample analyzer. The control method comprises the following steps: receiving detection tasks for a plurality of samples; the bearing mechanism rotates to a reaction container loading area corresponding to the reaction container loading mechanism so as to load an empty reaction container; the bearing mechanism rotates to a sample distribution area corresponding to the sample distribution mechanism so as to distribute part of the samples in the samples into the empty reaction container; the bearing mechanism rotates into a reagent distribution area corresponding to the reagent distribution mechanism so as to distribute detection reagent to the part of samples; moving the partial sample into the detection device to release the empty bits and detect the partial sample; wherein no other sample is dispensed during a period from the end of loading of the empty reaction vessel to the start of dispensing of the detection reagent.

Description

Control method for sample analyzer and sample analyzer

Technical Field

The present application relates to the field of chemiluminescent detection technology, and in particular, to a control method for a sample analyzer and a sample analyzer.

Background

Chemiluminescent detection is currently typically performed using fully automated chemiluminescent detection devices. The full-automatic detection device has the advantages that manual intervention or external intervention is not needed in the working process of the detection device, and the accuracy and the high efficiency of the detection process are guaranteed.

In the prior art, in order to detect as many samples as possible in a detection device at the same time, a scheme of a turntable type bearing mechanism is adopted for detection. And rotating the bearing mechanism to enable the empty load bit on the bearing mechanism to sequentially pass through the reaction container loading area, the sample distribution area and the reagent distribution area, so as to realize the loading, sample distribution and detection reagent distribution of the reaction container, and finally, moving the reaction container into the reaction area for detection so as to obtain a detection report.

However, in the above-described solutions, in order to achieve a high detection throughput, the carrying mechanism is intended to carry as high an amount of detection sample and reaction vessels as possible during the detection process, and to achieve parallel operation of the different components of the sample analyzer between different detection procedures. For example, the carrying mechanism can carry up to 200 reaction vessels, and the 200 reaction vessels can be carried by 4 carrying positions. At the same time, the carrier means has a plurality of actuating members, such as a reaction vessel loading means, a sample dispensing means and a reagent dispensing means. Therefore, what is sought is: the 4 carrying sites are all full carrying reaction vessels and different execution units may execute operations on different carrying sites simultaneously, e.g. simultaneously dispensing samples and reagents.

However, this control method can improve the detection throughput, but since the reaction vessel loading, sample dispensing and reagent dispensing are performed simultaneously and the respective operation durations are different, the operation time for the reaction vessel at each carrying position is limited by the longest operation time, i.e., the carrying mechanism is rotated again to reach the next execution part after the longest operation time is ended.

This results in a significantly longer time for the detection of the first group of samples in a batch, which is extremely disadvantageous for samples requiring urgent detection.

Disclosure of Invention

In order to solve or partially solve the problems in the prior art, the present application provides a control method for a sample analyzer and a sample analyzer, which can shorten the time from sample distribution to detection result of a first group of samples, thereby shortening the first report time and increasing the user experience.

A first aspect of the present application provides a control method for a sample analyzer having a carrying mechanism, a reaction vessel loading mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, and a detection device; the bearing mechanism is provided with a plurality of empty load positions at intervals along the circumferential direction of the bearing mechanism, and each empty load position is used for bearing a plurality of reaction containers; the bearing mechanism can rotate around the center of the bearing mechanism;

the control method comprises the following steps:

receiving detection tasks for a plurality of samples;

the bearing mechanism rotates to a reaction container loading area corresponding to the reaction container loading mechanism so as to load an empty reaction container;

the bearing mechanism rotates to a sample distribution area corresponding to the sample distribution mechanism so as to distribute part of samples in the samples into the empty reaction container;

the bearing mechanism rotates into a reagent distribution area corresponding to the reagent distribution mechanism so as to distribute the detection reagent to part of the samples;

moving a portion of the sample into a detection device to release the empty bits and detect the portion of the sample;

wherein no other sample is dispensed during a period from the end of loading of an empty reaction vessel to the start of dispensing of the detection reagent.

A second aspect of the present application provides a computer readable storage medium having stored thereon a computer program which, when executed on a control system of a sample analyzer, causes the control system to perform a method according to the above.

A third aspect of the present application provides a sample analyzer having a computer readable storage medium according to the above. Sample analyzers are in particular photo-activated chemiluminescent analyzers. The sample analyzer is equipped with two empty positions which are symmetrically distributed about the central axis of the carrier mechanism and whose initial positions correspond to the reaction vessel loading zone and the waiting zone, respectively.

A fourth aspect of the present application provides a sample analyzer having a computer readable storage medium according to the above. Sample analyzers are in particular photo-activated chemiluminescent analyzers. The sample analyzer is provided with four empty positions, the initial positions of which correspond to the reaction vessel loading zone, the sample dispensing zone, the waiting zone and the reagent dispensing zone, respectively.

The technical scheme that this application provided can include following beneficial effect: in the embodiment of the application, during the process of executing the detection task on at least part of the samples, the distribution of other samples is not executed in a period from the end of loading of the empty reaction container to the beginning of the distribution of the detection reagent. Compared with the method in the prior art that other samples need to be completely distributed after the samples are distributed, the method in the embodiment of the invention has the advantages that the time for generating the detection report of the first group of samples in one batch is greatly shortened, namely, the first report time is greatly shortened, so that the user experience is improved. At the same time, the control method according to the application does not have a great influence on the original detection flux. Therefore, the control method of the application ensures high detection flux while realizing short first report time, and has great advantages for emergency detection samples.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.

Drawings

The foregoing and other objects, features and advantages of the application will be apparent from the following more particular descriptions of exemplary embodiments of the application as illustrated in the accompanying drawings wherein like reference numbers generally represent like parts throughout the exemplary embodiments of the application.

Fig. 1 is a schematic structural view of a bearing mechanism according to an embodiment of the present disclosure;

FIG. 2 (a) is a schematic diagram of a step 200 shown in the prior art;

fig. 2 (b) is a schematic diagram of step 201 shown in the prior art;

FIG. 2 (c) is a schematic diagram of step 202 shown in the prior art;

fig. 2 (d) is a schematic diagram of step 203 shown in the prior art;

FIG. 3 is a flow chart of a control method for a sample analyzer shown in an embodiment of the present application;

FIG. 4 (a) is a schematic diagram of step 400 shown in an embodiment of the present application;

FIG. 4 (b) is a schematic diagram of step 401 shown in an embodiment of the present application;

FIG. 4 (c) is a schematic diagram of step 402 shown in an embodiment of the present application;

FIG. 4 (d) is a schematic diagram of step 403 shown in an embodiment of the present application;

FIG. 5 (a) is a schematic diagram of step 500 shown in an embodiment of the present application;

FIG. 5 (b) is a schematic diagram of step 501 shown in an embodiment of the present application;

FIG. 5 (c) is a schematic diagram of step 502 shown in an embodiment of the present application;

FIG. 6 (a) is a schematic diagram of step 600 shown in an embodiment of the present application;

FIG. 6 (b) is a schematic diagram of step 601 shown in an embodiment of the present application;

FIG. 6 (c) is a schematic diagram of step 602 shown in an embodiment of the present application;

fig. 6 (d) is a schematic diagram of step 603 shown in an embodiment of the present application.

Reference numerals: 1. a carrying mechanism; k1, no-load bit; 2. an empty reaction vessel; 3. a reaction vessel to which a sample is added; 30. a first reaction vessel; 31. a second reaction vessel; 4. a reaction vessel containing a detection reagent; 5. a reaction vessel loading mechanism; a1, a reaction vessel loading area; a2, a sample distribution area; a3, a waiting area; a4, a reagent distribution area; and J1, a detection device.

Detailed Description

Embodiments of the present application will be described in more detail below with reference to the accompanying drawings. While embodiments of the present application are shown in the drawings, it should be understood that the present application may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

The terminology used in the present application is for the purpose of describing particular embodiments only and is not intended to be limiting of the present application. As used in this application and the appended claims, the singular forms "a," "an," and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any or all possible combinations of one or more of the associated listed items.

It should be understood that although the terms "first," "second," "third," etc. may be used herein to describe various information, these information should not be limited by these terms. These terms are only used to distinguish one type of information from another. For example, a first message may also be referred to as a second message, and similarly, a second message may also be referred to as a first message, without departing from the scope of the present application. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present application, the meaning of "a plurality" is two or more, unless explicitly defined otherwise.

In addition, in the present application, the first group of empty reaction vessels, the second and third empty reaction vessels, the i-th group of empty reaction vessels, the i+1-th group of empty reaction vessels, the i+2-th group of empty reaction vessels and the i+3-th group of empty reaction vessels are each represented by an empty reaction vessel 2 in the drawing; the reaction vessel to which the first group of samples are added, the reaction vessel to which the i-th group of samples are added, the reaction vessel to which the i+1-th group of samples are added, and the reaction vessel to which the i+2-th group of samples are added are each represented by a reaction vessel 3 to which a sample is added in the drawing; the reaction vessel to which the first group of detection reagents is added, the reaction vessel to which the i-th group of detection reagents is added, the reaction vessel to which the i+1-th group of detection reagents is added, and the reaction vessel to which the i+2-th group of detection reagents is added are each represented by a reaction vessel 4 to which a sample is added in the drawing.

In the prior art, in order to detect as many samples as possible in a detection device at the same time, a scheme of a turntable type bearing mechanism is adopted for detection. Referring to fig. 1, 4 empty load bits K1 are provided on the carrying mechanism 1, and a reaction container loading mechanism 5, a sample dispensing mechanism (not shown), and a reagent dispensing mechanism (not shown) are provided around the carrying mechanism 1. The portion of the reaction container loading mechanism 5 corresponding to the carrying mechanism 1 forms a reaction container loading area A1, the portion of the sample distribution mechanism corresponding to the carrying mechanism 1 forms a sample distribution area A2, the portion of the reagent distribution mechanism corresponding to the carrying mechanism 1 forms a reagent distribution area A4, and a waiting area A3 is arranged between the sample distribution position A2 and the detection reagent distribution position A4. The 4 empty load bits K1 sequentially pass through a reaction container loading area A1, a sample distribution area A2, a waiting area A3 and a reagent distribution area A4 to realize the loading, sample distribution and detection reagent distribution of the reaction container, and finally, the empty load bits K1 are moved into a detection device J1 for detection to obtain a detection report.

In this application, "first report" is understood as: the sample analyzer detects a first group of samples in the samples after receiving a new batch of samples to obtain a detection result; in particular, the detection result of the detection of the first group of samples in the first batch after the transition of the carrier from the stationary standby state to the operating state can be understood as a result.

The specific procedure of generating the first report in the prior art includes steps 200 to 204:

step 200: referring to fig. 2 (a), a first group of empty reaction vessels in a first batch are loaded onto a carrier 1 at empty load position K1 of the reaction vessel loading zone A1 (i.e. 6 o' clock).

Step 201: referring to fig. 2 (b), the carrying mechanism 1 is driven to rotate 90 ° clockwise, the first group of empty reaction vessels in the original 6 o 'clock direction is rotated to the sample distribution area A2 (i.e., 9 o' clock direction), and the first group of samples in the first batch are distributed to the first group of empty reaction vessels and denoted as first reaction vessels 30; at the same time, empty load bit K1 located in reagent dispensing zone A4 (i.e., 3 o 'clock) is transferred to reaction vessel loading zone A1 (i.e., 6 o' clock) and a second set of empty reaction vessels in the first batch are loaded into this empty load bit K1.

Step 202: referring to fig. 2 (c), the carrier 1 is continuously driven to rotate clockwise by 90 °, the first reaction vessel 30 is rotated to the waiting area A3 (i.e., 12 o' clock direction), the second group of empty reaction vessels is rotated to the sample distribution area A2, and the second group of samples are distributed to the second group of empty reaction vessels and denoted as second reaction vessel 31; while continuing to load a third set of empty reaction vessels onto another empty load position K1 located in the reaction vessel loading zone A1 (i.e., 6 o' clock).

Step 203: referring to fig. 2 (d), after the first group of samples are dispensed, the carrying mechanism 1 is driven to rotate 90 ° clockwise again, so that the first reaction vessel 30 is rotated to the reagent dispensing area A4, the second reaction vessel 31 is rotated to the waiting area A3, and the third group of empty reaction vessels is rotated to the sample dispensing area A2; and dispensing a first set of detection reagents into the first reaction vessel 30 and a third set of samples into a third set of empty reaction vessels; while continuing to load an empty reaction vessel onto empty load position K1 located in reaction vessel load zone A1 (i.e., 6 o' clock).

Step 204: step 203 is repeated until detection of all samples in the first batch is completed.

In the above-described flow, the first reaction vessel 30 needs to wait for the second reaction vessel 31 to perform the second group sample distribution at the waiting position A3 after completing the first group sample distribution. Since the sample dispensing time is far longer than the reaction vessel loading time, the time from the loading of the first reaction vessel 30 from the empty reaction vessel to the dispensing of the first set of detection reagents corresponds to the sum of the one reaction vessel loading time and the two sample dispensing times. In other words, the time elapsed for the first reaction vessel before reaching the detection device J1 includes one reaction vessel loading time, two sample dispensing times, and one reagent dispensing time, which results in a longer time to generate the first report. This is extremely disadvantageous for emergency detection tasks and also reduces the user experience.

In view of the above problems, embodiments of the present application provide a control method for a sample analyzer, which can shorten the time from sample distribution to detection of a first group of samples in a first batch, thereby shortening the first report time and increasing the user experience.

The following describes the technical scheme of the embodiments of the present application in detail with reference to the accompanying drawings.

The sample analyzer of the embodiment of the present application has a carrying mechanism 1, a reaction container loading mechanism 5, a sample dispensing mechanism, a reagent dispensing mechanism, and a detection device J1. The carrying mechanism 1 is of a disc type structure, and a plurality of empty load positions K1 which are arranged at intervals along the circumferential direction of the carrying mechanism 1 are arranged on the carrying mechanism 1, and each empty load position is used for carrying a plurality of reaction containers. And the circumference direction of the bearing mechanism 1 is sequentially provided with a reaction container loading mechanism 5, a sample distribution mechanism and a reagent distribution mechanism at intervals, and a luminescence detection mechanism is arranged close to the reagent distribution mechanism. The carrying mechanism 1 is provided with a reaction container loading area A1, a sample dispensing area A2 and a reagent dispensing area A4 at positions corresponding to the reaction container loading mechanism 5, the sample dispensing mechanism and the reagent dispensing mechanism, respectively, and a waiting area A3 is formed between the sample dispensing area A2 and the reagent dispensing area A4. The reaction vessel loading mechanism 5 is used for loading the empty reaction vessel 2 to the empty load position K1 when the load mechanism 1 rotates to the position that the empty load position K1 on the load mechanism 1 is positioned in the reaction vessel loading area A1; the sample distribution mechanism is used for distributing samples to the empty reaction container 2 when the bearing mechanism 1 rotates until the empty reaction container 2 is positioned in the sample distribution area A2; the reagent dispensing mechanism is used for dispensing detection reagent to the reaction container 3 added with the sample when the bearing mechanism 1 rotates to the position that the reaction container 3 added with the sample is positioned in the reagent dispensing zone A4; the luminescence detection means is for performing luminescence detection of a mixture of the sample and the reagent in the reaction container 4 to which the detection reagent is added.

Fig. 3 is a flow chart of a control method for an exemplary sample analyzer shown in an embodiment of the present application.

Referring to fig. 3, the control method for a sample analyzer includes steps 300 to 303:

step 300: it is determined whether the carrying mechanism 1 is in the initial no-load operation state.

The initial idle running state means that the carrying mechanism 1 transits from a stationary standby state to a running state, and the carrying positions on the carrying mechanism 1 are all idle states.

Step 301: if the carrying mechanism 1 is in an initial idle running state, executing a front detection task of a first group of samples in a first batch, wherein the front detection task refers to a task executed before the samples are subjected to luminescence detection, and the front detection task comprises loading of a first group of empty reaction containers, distribution of the first group of samples and distribution of a first group of detection reagents; wherein no further sample is dispensed during a period from the end of loading of the first set of empty reaction vessels to the start of dispensing of the first set of detection reagents.

When the carrying mechanism 1 is in the initial no-load running state, the detection result generated by detecting the first group of samples in the first batch is reported.

The dispensing of the other samples is not performed during the period from the end of the loading of the first set of empty reaction vessels to the start of the dispensing of the first set of detection reagents, but the loading of the other empty reaction vessels may be performed. If the loading of the second set of empty reaction vessels is performed during this time period, but the dispensing of the second set of samples is not performed, this means that the dispensing of the second set of samples can only be performed at the earliest of the same time as the dispensing of the first set of detection reagents. This is because the second group of empty reaction vessels has not reached the sample distribution area A2 in this previous period of time, and thus no other sample distribution can be performed.

In the process of the pre-detection task of the first group of samples in the first batch, the second group of samples are not waited for to be distributed, so that the time from the loading of the empty reaction container to the distribution of the detection reagent is greatly shortened for the first group of samples in the first batch, namely, the time is equivalent to the sum of the time for loading the empty reaction container and the time for distributing the samples, and compared with the prior art flow shown in fig. 2, the time for distributing the samples is shortened. Therefore, the generation time of the first report is greatly shortened, and the user experience is improved.

As one embodiment of the present application, the loading of the second set of empty reaction vessels is performed during a period of time from the end of the dispensing of the first set of samples to the beginning of the dispensing of the first set of detection reagents.

In connection with the above description, it is because the loading of the second set of empty reaction containers is in a period from the end of the dispensing of the first set of samples to the start of the dispensing of the first set of detection reagents, so that the dispensing of other samples cannot be performed in a period from the end of the loading of the first set of empty reaction containers to the start of the dispensing of the first set of detection reagents.

Step 302: after the end of the task of pre-detection of the first set of samples in the first batch is performed, the first set of samples is transferred to the detection device to release the empty bit K1.

The first group of samples are transferred to the detection device along with the reaction container, and the corresponding position on the transfer bearing mechanism 1 is an empty load position K1.

Step 303: a first set of samples in a first batch is tested in a testing device J1.

And after the detection of the first group of samples in the first batch is completed, the generated detection result is the first report.

In the embodiment of the application, when the carrying mechanism 1 is in the initial idle running state, the distribution of the second group of samples is not waited in the process of executing the pre-detection task of the first group of samples in the first batch, so that the pre-detection task time of the first group of samples in the first batch is greatly shortened, and the generation time of the first report is greatly shortened.

As an alternative embodiment of the present application, the carrying mechanism 1 for executing the sample analyzer of fig. 3 includes four empty bits K1, and the four empty bits K1 are uniformly spaced apart along the circumferential direction of the carrying mechanism 1; and the initial positions of the four empty bits K1 correspond to the reaction container loading area A1, the sample dispensing area A2, the waiting area A3, and the reagent dispensing area A4. In this embodiment, the four idle bits K1 are spaced apart by 90 °. The carrying mechanism 1 is driven to rotate 90 degrees in a clockwise direction each time, so that four empty load positions K1 are respectively positioned in the reaction vessel loading area A1, the sample distribution area A2, the waiting area A3 and the reagent distribution area A4.

Performing a pre-detection task for a first set of samples in a first batch includes steps 400 through 405:

steps 400 to 405 are specifically described below with reference to fig. 4 (a) to 4 (d):

step 400: referring to fig. 4 (a), the carrier 1 is rotated until an empty load K1 on the carrier 1 is located in the reaction vessel loading area A1, and a first group of empty reaction vessels in a first lot is loaded into the empty load K1.

An empty reaction vessel means that the reaction vessel is empty and no sample or detection reagent is dispensed.

Step 401: referring to fig. 4 (b), the carrier 1 is rotated again until the first group of empty reaction vessels is within the sample distribution area A2, and the first group of samples in the first lot are distributed into the first group of empty reaction vessels.

This step only performs the operation of distributing the first set of samples in the first batch into the first set of empty reaction vessels, and does not perform any operation on the other empty bits K1.

Step 402: as shown in fig. 4 (c), the carrier 1 is continuously rotated until another empty load K1 on the carrier 1 is located in the reaction vessel loading area A1, and a second group of empty reaction vessels in the first batch is loaded to the empty load K1; simultaneously, the reaction container added with the first group of samples rotates to a waiting area A3 to wait for loading of the second group of empty reaction containers; and no operation is performed on the other empty bits K1.

The waiting area A3 in the embodiment of the present application is located between the sample distribution area A2 and the reagent distribution area A4, but the specific position of the waiting area A3 is not limited, and the other one of the empty positions K1 is transferred into the reaction vessel loading area A1. When the other empty load position K1 is transferred into the reaction vessel loading area A1, the position of the reaction vessel added with the first group of samples on the bearing mechanism 1 is the waiting area A3.

In addition, the second group of empty reaction containers are loaded to the other empty load bit K1 for the parallel detection of multiple groups of samples, so that the subsequent detection efficiency is improved.

Step 403: referring to fig. 4 (d), the rotation of the carrier 1 is continued until the reaction vessel to which the first set of samples is added is within the reagent dispensing zone A4, and the first set of detection reagents in the first lot is dispensed into the reaction vessel.

As a preferred embodiment, when the first set of samples is within the reagent dispensing zone A4, the second set of empty reaction vessels is located in the sample dispensing zone A2; a second set of samples is dispensed to a second set of empty reaction vessels while a first set of detection reagents is dispensed to the reaction vessels to which the first set of samples is added within the reagent dispensing zone A4.

Because the time of the detection reagent distribution and the sample distribution are close, the distribution of the first group of samples and the distribution of the second group of detection reagents can be simultaneously performed, so that the first report time can be shortened, and the subsequent detection is not influenced.

Step 404: the reaction vessel with the first set of detection reagents added thereto is moved into the detection device J1 to perform luminescence detection on the first set of samples in the first lot.

Step 405: and after the luminescence detection of the first group of samples in the first batch is completed, generating a first report.

In addition, the operation of dispensing the second set of samples in the first lot can be performed during the process of moving the reaction vessel to which the first set of detection reagents in the first lot is added into the detection device J1.

Since the first report generation time is the sum of the pre-detection and the luminescence detection time, and the luminescence detection time is fixed, the first report generation time is mainly determined by the pre-detection time. The pre-detection time includes a pre-detection time, i.e., a time from the first group of samples in the first lot to the time when the reaction vessel to which the first group of detection reagents in the first lot is added is pushed into the detection device J1. In the process of generating the first report, when the reaction container added with the first group of samples in the first batch is in the waiting area A3, another empty load bit K1 on the carrying mechanism 1 is located in the reaction container loading area A1, and the second group of empty reaction containers in the first batch are loaded to the empty load bit K1. Compared with the method in the prior art that the first group of samples are dispensed and then the next group of samples are required to be dispensed at the waiting position A3, the pre-detection time in the prior art is the loading time T4 of a group of empty reaction vessels, the time 2T1 of two groups of samples are dispensed, the time T2 of one group of detection reagents is dispensed, and the time T3 from the reaction vessel 4 with the detection reagents pushed to the detection device J1 is added; the pre-detection time in the embodiment of the present application is a loading time t4 of a set of empty reaction vessels, a sample distribution time t1+a detection reagent distribution time t2+a time T3 from the reaction vessel 4 with the detection reagent pushed into the detection device J1. Because the loading time of the empty reaction container is greatly shorter than the sample distribution time, the embodiment of the application improves the acquisition efficiency of the first report by shortening the pre-detection time, thereby increasing the user experience.

As a preferred embodiment, the control method further comprises the steps of:

step 500: referring to fig. 5 (a), when the first set of samples is located in the reagent dispensing area A4, the other empty-load bit K1 on the carrying mechanism 1 is located in the reaction-container loading area A1, and the second set of empty reaction containers is located in the sample dispensing area A2, the second set of samples is dispensed to the second set of empty reaction containers and the third set of empty reaction containers is loaded to the other empty-load bit K1 while the dispensing task of the first set of detection reagents is performed.

Since the first group of samples in the first batch generates a first report after luminescence detection, the detection of the subsequent samples is required after the first report. In order to realize synchronous and parallel detection of multiple groups of samples in the first batch and utilize all empty-load bits K1, the embodiment of the application distributes detection reagents into the reaction containers added with the first group of samples in the first batch and distributes samples into the second group of empty reaction containers in the first batch; and loading a third group of empty reaction vessels in the first batch to the empty load bit K1 positioned in the reaction vessel loading area A1 on the bearing mechanism 1 so as not to influence the generation of subsequent detection results.

As a preferred embodiment, after the detection of the first set of samples in the first batch in the detection device J1, the following steps are further included:

loading an n+1th group of empty reaction containers to an empty position located in the reaction container loading area when the n group of empty reaction containers is located in the sample distribution area and the n group of samples is distributed, wherein n >1;

sequentially moving the nth group of samples to the waiting area and the reagent distribution area to finish distribution of detection reagents;

the nth set of samples is transferred to a detection device for detection.

The above steps can be specifically described by steps 501 to 503:

step 501: referring to fig. 5 (b), the rotation of the carrying mechanism 1 is continued until the reaction vessel to which the i-th group sample is added and the i+1th group sample are located in the waiting area A3 and the sample distributing area A2, and the i+1th group sample is distributed to the i+1th group; simultaneously loading the i+2th group to an empty load bit K1 positioned in a reaction vessel loading area A1 on the bearing mechanism 1; wherein, the reaction vessel to which the i-th group sample is added is denoted as a first reaction vessel 30, and the reaction vessel to which the i+1th group sample is added is denoted as a second reaction vessel 31; where i=2, 3, 4..m, m is the total number of groups of samples in the first batch, and m is a positive integer.

Since the sample-added reaction vessel 3 located in the sample distribution area A2 is formed after the sample addition, the sample-added reaction vessel 3 located in the waiting area A3 is referred to as a first reaction vessel 30 and the sample-added reaction vessel 3 located in the sample distribution area A2 after the sample addition is referred to as a second reaction vessel 31 in order to distinguish the sample-added reaction vessel 3 from the sample-added reaction vessel 3 located in the waiting area A3.

In addition, in the embodiment of the present application, after the first report is generated, the first reaction container 30 waits for the loading of the next group and the loading of the next group in the waiting area A3, so that all the four empty load bits K1 are utilized, so as not to affect the overall detection speed.

Step 502: as shown in fig. 5 (c), the rotation of the carrying mechanism 1 is continued until the first reaction container 30, the second reaction container 31 and the i+2 th component are located in the reagent dispensing area A4, the waiting area A3 and the sample dispensing area A2, and the i-th detection reagent and the i+2-th sample are respectively dispensed to the first reaction container 30 and the i+2-th component; and simultaneously loading the ith+3rd group to an empty load bit K1 positioned in a reaction vessel loading area A1 on the bearing mechanism 1.

Step 503: after the first reaction vessel 30 completes the dispensing of the ith group of detection reagents, the ith group of samples in the first reaction vessel 30 are subjected to luminescence detection.

In the process of moving the first reaction container 30 into the detection device J1, the next group of sample distribution and the next group of loading can be still performed, so that parallel operation of multiple tasks is realized in time, and the detection efficiency is improved.

The subsequent detection only needs to repeat the steps 501 to 503, and the four idle load bits K1 are fully utilized, so that the detection efficiency is improved to the greatest extent.

As a further alternative embodiment, the support means can be further improved on the basis of the embodiment shown in fig. 3 to 5 (c) in order to further reduce costs.

The carrier 1 of the sample analyzer comprises two empty carriers K1, which are symmetrically distributed about the central axis of the carrier, i.e. spaced apart by 180 °. The initial positions of the two empty load bits K1 respectively correspond to the loading area and the waiting area of the reaction vessel.

The reaction vessel loading area A1, the sample distribution area A2, the waiting area A3 and the reagent distribution area A4 in the embodiment of the application are distributed in a 90-degree mode. The carrying mechanism 1 is driven to rotate 90 degrees in a clockwise direction each time, so that two empty load positions K1 are respectively positioned in two areas which are distributed at 180 degrees in two of the reaction vessel loading area A1, the sample distribution area A2, the waiting area A3 and the reagent distribution area A4.

The present embodiment performs the same steps 600 to 603 for all samples. Specifically, fig. 6 (a) shows step 600, fig. 6 (b) shows step 601, fig. 6 (c) shows step 602, and fig. 6 (d) shows step 603.

Step 600: referring to fig. 6 (a), the carrier 1 is rotated until an empty load position K1 on the carrier 1 is located in the reaction vessel loading area A1, and a set of empty reaction vessels is loaded into the empty load position K1.

Step 601: referring to fig. 6 (b), the carrying mechanism 1 is rotated again until the loaded set of empty reaction containers is within the sample distribution area A2, and a set of samples is distributed into the first set of empty reaction containers.

Step 602: as shown in fig. 6 (c), the carrier 1 is continuously rotated until another empty load K1 on the carrier 1 is located in the reaction vessel loading area A1, and another group of empty reaction vessels is loaded into the empty load K1; at the same time, the reaction vessel to which the sample has been added is rotated to the waiting area A3 to wait for loading of another set of empty reaction vessels.

Step 603: referring to fig. 6 (d), the rotation of the carrier 1 is continued until the reaction vessel to which the sample has been added is located in the reagent dispensing zone A4, and the detection reagent is dispensed into the reaction vessel. At the same time, another set of empty reaction vessels is in sample distribution area A2, and another set of samples is distributed to this set of reaction vessels.

In summary, in embodiments of the present application:

when the nth group reaction container added with the nth group sample is positioned in the waiting area A3, loading the (n+1) th group empty reaction container into the empty position K1 positioned in the reaction container loading area A1, wherein n is more than 1;

moving the nth set of samples to the reagent dispensing zone to complete the dispensing of the test reagent;

the nth set of samples is transferred to a detection device for detection.

Thus, after the first report is generated, sample distribution and detection reagent distribution are alternately performed on the two empty-load bits K1 to complete all subsequent detections.

In this embodiment, by reducing the idle bits to two, the acquisition efficiency of the first report is also improved.

The following compares the prior art scheme (comparative example below) with the two schemes of the present embodiment (the first scheme is that the carrier 1 has four empty bits K1, and the second scheme is that the carrier has two empty bits K1).

Assuming that the loading takes 20 seconds, the sample dispensing takes 10 minutes, and the total of 15 minutes (64 reaction vessels can be carried per empty load) is required for the detection reagent dispensing and pushing the reaction vessel 4 with the detection reagent into the detection device J1. The limiting factor in the speed of testing is the speed of sample dispensing or reagent dispensing. In this embodiment, the test reagent dispensing time is 15 minutes, i.e., 900 seconds, which is greater than the sample dispensing time as assumed above. Thus, limit test speed= (3600 s/test reagent dispensing time) number of reaction vessels per empty load.

The prior art protocol and the two protocols of the examples of the present application have the following table of pre-test times and limit test speeds:

	time to pre-detection	Limit test speed
			Comparative example	35min	256 test/h
First scheme	25min20s	256 test/h
			Second scheme	25min20s	250 test/h

The pre-detection time in the comparative example is the time 2T1 of two sets of samples dispensing+the time T2 of one set of detection reagents dispensing+the time T3 from one reaction vessel 4 to which the detection reagent is pushed into the detection device J1. The total time was 35 minutes.

The pre-detection time in the first and second aspects is the loading time t4 of a set of empty reaction vessels, the time t1 of a set of sample distributions, the time t2 of a set of detection reagent distributions, and the time T3 from the reaction vessel 4 with the detection reagent pushed into the detection device J1. Totaling 25 minutes and 20 seconds. The time period is shortened by 9 minutes and 40 seconds compared with the comparative example.

For the first scheme, since the time required for the step of the first report sum is the same as that of the comparative example, its limit test speed= (3600/900) ×64=256 tests/h; the same as in the comparative example.

For the second scheme, since each round of testing requires a separate waiting load, an additional 20 seconds is required, limit test speed= (3600/920) 64=250 tests/h.

From the data, the control method of the application not only greatly shortens the generation time of the first report, but also ensures the detection flux. Even in the second scheme of shortening the first reporting time by reducing the idle bits, there is no great influence on the limit detection throughput.

Corresponding to the foregoing embodiments of the application function implementation device, the present application further provides a computer-readable storage medium, a sample analyzer, and corresponding embodiments, where the computer-readable storage medium stores a computer program, and when the computer program is executed on a control system of the sample analyzer, the computer program causes the control system to at least execute the control method shown in fig. 6 (a) to 6 (d).

The sample analyzer has the aforementioned computer-readable storage medium.

In an alternative embodiment, the control system of the sample analyzer may include a determination module and a control module.

The judging module is used for judging whether the bearing mechanism 1 is in an initial no-load running state.

The control module is connected to the judging module and is used for receiving the judging result of the judging module, and if the judging result is that the bearing mechanism 1 is in the initial idle running state, executing a computer program stored on a computer readable storage medium, wherein the computer program enables the control system to execute the control method described with reference to fig. 3 to 5 (c).

The embodiments of the present application have been described above, the foregoing description is exemplary, not exhaustive, and not limited to the embodiments disclosed. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the various embodiments described. The terminology used herein was chosen in order to best explain the principles of the embodiments, the practical application, or the improvement of technology in the marketplace, or to enable others of ordinary skill in the art to understand the embodiments disclosed herein.

Claims (11)

1. A control method for a sample analyzer, characterized in that the sample analyzer has a carrying mechanism, a reaction vessel loading mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, and a detecting device; the bearing mechanism is provided with a plurality of empty load positions at intervals along the circumferential direction of the bearing mechanism, and each empty load position is used for bearing a plurality of reaction containers; the bearing mechanism can rotate around the center of the bearing mechanism;

the control method comprises the following steps:

receiving detection tasks for a plurality of samples;

the bearing mechanism rotates to a reaction container loading area corresponding to the reaction container loading mechanism so as to load an empty reaction container;

the bearing mechanism rotates to a sample distribution area corresponding to the sample distribution mechanism so as to distribute part of the samples in the samples into the empty reaction container;

the bearing mechanism rotates into a reagent distribution area corresponding to the reagent distribution mechanism so as to distribute detection reagent to the part of samples;

moving the partial sample into the detection device to release the empty bits and detect the partial sample;

wherein no other sample is dispensed during a period from the end of loading of the empty reaction vessel to the start of dispensing of the detection reagent.

2. The control method according to claim 1, characterized in that the control method further comprises:

judging whether the bearing mechanism is in an initial idle running state or not;

if yes, executing a front detection task of a first group of samples in the first batch, wherein the front detection task comprises loading of a first group of empty reaction containers, distribution of the first group of samples and distribution of a first group of detection reagents; wherein no further sample is dispensed during a period from the end of loading of the first set of empty reaction vessels to the start of dispensing of the first set of detection reagents.

3. The method according to claim 2, wherein the loading of the second set of empty reaction vessels is performed during a period from the end of the dispensing of the first set of samples to the start of the dispensing of the first set of detection reagents.

4. A control method for a sample analyzer according to claim 3, wherein the performing the pre-detection task of the first set of samples in the first batch comprises the steps of:

rotating the bearing mechanism to enable one empty load bit on the bearing mechanism to sequentially pass through the reaction container loading area, the sample distribution area, the waiting area and the reagent distribution area;

when the first group of samples are in the waiting area, the other empty load position on the bearing mechanism is positioned in the loading area of the reaction container, and the second group of empty reaction containers are loaded on the empty load position.

5. The control method for a sample analyzer according to claim 4, wherein:

the second set of empty reaction vessels is located in the sample distribution region when the first set of samples is within the reagent distribution region;

and dispensing a second set of samples to the second set of empty reaction vessels while dispensing the first set of detection reagents to the reaction vessels with the first set of samples added thereto within the reagent dispensing zone.

6. The control method for a sample analyzer according to claim 5, characterized in that:

the carrying mechanism is provided with four empty load positions, the four empty load positions are uniformly distributed at intervals along the circumferential direction of the carrying mechanism, and the initial positions of the four empty load positions respectively correspond to the reaction container loading area, the sample distribution area, the waiting area and the reagent distribution area.

7. The control method for a sample analyzer according to claim 6, further comprising the steps of:

loading an n+1th set of empty reaction vessels to empty bits located in the reaction vessel loading zone when the n-th set of empty reaction vessels is located in the sample distribution zone and the n-th set of samples is distributed, wherein n >1;

moving the nth group of samples to the waiting area and the reagent distribution area in sequence to finish detection reagent distribution;

the nth set of samples is transferred to the detection device for detection.

8. The control method for a sample analyzer according to claim 1, characterized in that:

the bearing mechanism is provided with two empty load positions, the two empty load positions are symmetrically distributed about the central axis of the bearing mechanism, and the initial positions of the two empty load positions respectively correspond to the loading area and the waiting area of the reaction container.

9. A computer readable storage medium, on which a computer program is stored, characterized in that the computer program, when executed on a control system of a sample analyzer, causes the control system to perform the method according to any one of claims 1 to 8.

10. A sample analyzer having the computer readable storage medium of claim 9, the sample analyzer having a carrier mechanism, a reaction vessel loading mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, and a detection device; wherein, the bearing mechanism is provided with two empty load positions along the circumferential direction at intervals, and each empty load position is used for bearing a plurality of reaction containers; the bearing mechanism can rotate around the center of the bearing mechanism, the two empty load positions are symmetrically distributed around the central axis of the bearing mechanism, and the initial positions of the two empty load positions respectively correspond to the loading area and the waiting area of the reaction container.

11. A sample analyzer having the computer readable storage medium of claim 9, the sample analyzer having a carrier mechanism, a reaction vessel loading mechanism, a sample dispensing mechanism, a reagent dispensing mechanism, and a detection device; the bearing mechanism is provided with four empty load positions at intervals along the circumferential direction of the bearing mechanism, and each empty load position is used for bearing a plurality of reaction containers; and the bearing mechanism can rotate around the center of the bearing mechanism, and the initial positions of the four idle positions respectively correspond to the loading area, the sample distribution area, the waiting area and the reagent distribution area of the reaction container.