CN117797354A - Blood purifying pipeline device - Google Patents

Abstract

The application belongs to the technical field of blood purification equipment, and discloses a blood purification pipeline device which comprises a main through pipe and a branch pipeline component; two ends of the main through pipe are respectively used for communicating an arterial pipeline and the dialyzer; the communicating pipe of the branch pipe assembly is arranged between the first branch pipe and the second branch pipe, the first branch pipe is provided with a first perfusion device, the second branch pipe is provided with a second perfusion device, the first branch pipe and the second branch pipe can be selectively communicated with the main through pipe so that the first perfusion device is connected with the dialyzer in parallel, or the second perfusion device is connected with the dialyzer in parallel, or the first perfusion device and the second perfusion device are connected with the dialyzer in parallel in sequence; the communication pipeline can be communicated with the first branch pipeline and the second branch pipeline so that the first perfusion device is connected in series with the second perfusion device and then connected in parallel with the dialyzer. The blood purification pipeline device can meet various use requirements of perfusion sequential treatment and perfusion parallel hemodialysis treatment, avoids open disassembly, has a simple structure, is easy to select and apply, and simplifies operation difficulty.

Description

Blood purifying pipeline device

Technical Field

The invention relates to the technical field of blood purification equipment, in particular to a blood purification pipeline device.

Background

Blood perfusion (hemoperfusion, HP) is a therapeutic method for introducing the blood of a patient from the body to the extracorporeal circulation system and removing the substances by the adsorption and combination of adsorbents (activated carbon, resin and other materials) in the perfusion device and metabolites, toxic substances and medicines to be removed in the body. The clinical blood perfusion has three treatment methods of single blood perfusion, serial blood perfusion of hemodialysis and combined blood perfusion combined hemodialysis. The perfusion device and the filter are connected in series by a pipeline through a serial pipeline which is used conventionally in clinic, the treatment time limit of the perfusion device is generally 2 hours, the perfusion device needs to be withdrawn after the perfusion is finished, and the service time of the filter is generally more than 4 hours, so that the perfusion device needs to be detached in an open way during the treatment, and the blood of a patient possibly overflows out of the pipeline to cause the blood infection of the patient, or the hand of medical staff is polluted, or a pollution instrument is formed, or cross infection among patients is caused, and the serious potential safety hazard exists.

The consensus of clinical application experts (2022 edition) of the artificial liver blood purification technology indicates that the role of the artificial liver blood purification technology in the treatment of liver failure is already confirmed, and the clinical application of other diseases is also expanded. Blood perfusion (HP)/Plasma Perfusion (PP) (HP/PP) is to introduce the blood of a patient from the body to an extracorporeal circulation system, and remove the substances by adsorption and combination of adsorbents (activated carbon, resin and other materials) in the perfusion apparatus and metabolites, toxins, medicines and the like to be removed in the body. HP is the whole blood of a patient directly flows through a perfusion device, and PP is the blood which is separated from the whole blood and then flows through the perfusion device, various toxins in the blood are adsorbed, and the blood form components to be combined and returned into the body. On this basis, some complicated artificial liver treatments are now being developed and implemented clinically. Currently, complex modes of artificial liver treatment include paired plasmafiltration adsorption (CPFA), dual Plasma Molecular Adsorption System (DPMAS), molecular Adsorption Recirculation System (MARS); several combined modes of treatment are also proposed in the consensus. The pipeline connection of the treatment modes is complex, and the clinical study cost is high.

In the above-described combination therapy mode, it is often necessary to use a plurality of perfusion apparatuses. The parallel pipeline can continue to effectively carry out hemodialysis treatment under the condition that a perfusion device is not required to be separated, the existing parallel pipeline for combined hemodialysis of blood perfusion generally has the problems of complex pipeline structure, higher operation difficulty and higher operation requirement on medical staff, and in the face of different treatment modes, the requirements on the number of perfusion devices and the use modes are different, so that the use requirements of sequential perfusion treatment and parallel hemodialysis perfusion treatment are difficult to be simultaneously met.

Disclosure of Invention

The invention aims to provide a blood purification pipeline device, which can solve the problems that the existing parallel pipeline device has a complex structure and high operation difficulty, and the use requirements of perfusion sequential treatment and perfusion parallel hemodialysis treatment are difficult to meet simultaneously.

To achieve the purpose, the invention adopts the following technical scheme:

providing a blood purification tubing set comprising:

one end of the main through pipe is used for being communicated with an arterial pipeline, and the other end of the main through pipe is used for being communicated with a dialyzer;

the branch pipeline assembly comprises a first branch pipeline, a first perfusion device, a second branch pipeline, a second perfusion device and a communication pipeline, wherein the communication pipeline is arranged between the first branch pipeline and the second branch pipeline, the first perfusion device is arranged on the first branch pipeline, the second perfusion device is arranged on the second branch pipeline, and the first branch pipeline and the second branch pipeline can be selectively communicated with the main through pipe so that the first perfusion device is connected with the dialyzer in parallel, or the second perfusion device is connected with the dialyzer in parallel, or the first perfusion device and the second perfusion device are sequentially connected with the dialyzer in parallel;

the communication pipeline can be communicated with the first branch pipeline and the second branch pipeline so that the first perfusion device is connected in series with the second perfusion device and then connected in parallel with the dialyzer.

In one embodiment, the communication pipeline comprises a communication main pipe, a first branch pipe and a second branch pipe, one end of the communication main pipe is connected with the main pipe, the other end of the communication main pipe is connected with the first branch pipe and the second branch pipe, the other end of the first branch pipe, which is far away from the communication main pipe, is connected with the first branch pipeline, and the other end of the second branch pipe, which is far away from the communication main pipe, is connected with the second branch pipeline; and two of the communication main pipe, the first branch pipe and the second branch pipe are selectively communicated.

In one embodiment, the first branch pipe and the second branch pipe are symmetrically arranged at two sides of the main communication pipe so that the main communication pipe is in a Y-shaped structure, and the first branch pipe and the second branch pipe are symmetrically arranged at two sides of the main communication pipe respectively so as to be connected with the first branch pipe and the second branch pipe respectively.

In one embodiment, the branch pipe assembly further comprises a first switch, a second switch and a third switch, the first switch is arranged on the main communication pipe, the second switch is arranged on the first branch pipe or the first branch pipe, the third switch is arranged on the second branch pipe or the second branch pipe, and two of the first switch, the second switch and the third switch are selectively opened, so that two of the main communication pipe, the first branch pipe and the second branch pipe are selectively communicated.

In one embodiment, an outlet end of the first perfusion device is connected with the first branch pipeline, an inlet end of the first perfusion device is connected with the first branch pipeline, and the second switch is arranged on the first branch pipeline; and/or the number of the groups of groups,

the inlet end of the second perfusion device is connected with the second branch pipeline, the outlet end of the second perfusion device is connected with the second branch pipeline, and the third switch is arranged on the second branch pipeline.

In one embodiment, along the flow direction of the liquid flow, on the main pipe, the second branch pipe, the main pipe and the first branch pipe are sequentially arranged, the branch pipe assembly further comprises a fourth switch and a fifth switch which are both arranged on the main pipe, the fourth switch is located between the first branch pipe and the main pipe, and the fifth switch is located between the main pipe and the second branch pipe.

In one embodiment, the second switch is disposed on the first branch pipeline, the third switch is disposed on the second branch pipeline, the branch pipeline assembly further includes a first perfusion switch and a second perfusion switch, the first perfusion switch is disposed on the first branch pipeline, and the second perfusion switch is disposed on the second branch pipeline.

In one embodiment, the blood purification tubing set further comprises a third emitter assembly comprising a third emitter, the dialyzer being selectively connected in parallel to either the branch tubing assembly or the third emitter assembly.

In one embodiment, the third perfusion unit further includes a third branch pipe and a fourth branch pipe, one end of the third branch pipe is connected to the outlet end of the third perfusion unit, the other end of the third branch pipe is connected to the first branch pipe, one end of the fourth branch pipe is connected to the inlet end of the third perfusion unit, and the other end of the fourth branch pipe is connected to the second branch pipe.

In one embodiment, the blood purifying pipeline device further comprises a reserved branch pipeline, the reserved branch pipeline is connected to the main through pipe, and the reserved branch pipeline can be selectively communicated with the main through pipe through liquid flow; and/or the number of the groups of groups,

the blood purification pipeline device further comprises a waste liquid discharge branch pipeline, one end of the waste liquid discharge branch pipeline is connected with the main through pipe, the other end of the waste liquid discharge branch pipeline is connected with the waste liquid collecting structure, and the waste liquid discharge branch pipeline can be selectively communicated with the main through pipe; the blood purification pipeline device further comprises a sixth switch, wherein the sixth switch is arranged on the main through pipe and is positioned at the downstream of the waste liquid discharge branch pipeline along the flowing direction of liquid flow; and/or the number of the groups of groups,

the main through pipe is provided with a first sampling interface and a second sampling interface, and the first sampling interface is respectively positioned at the upstream and downstream of the branch pipeline component along the flow direction of liquid flow.

The invention has the beneficial effects that:

the invention provides a blood purifying pipeline device which comprises a main through pipe and a branch pipeline assembly. One end of the main through pipe is used for being communicated with the arterial pipeline, and the other end of the main through pipe is used for being communicated with the dialyzer. The branch pipeline assembly comprises a first branch pipeline, a first perfusion device, a second branch pipeline, a second perfusion device and a communication pipeline. The first perfusion device is arranged on the first branch pipeline, and the second perfusion device is arranged on the second branch pipeline. The first branch pipeline and the second branch pipeline can be selectively communicated with the main through pipe so that the first perfusion device is connected with the dialyzer in parallel, or the second perfusion device is connected with the dialyzer in parallel; that is, the first branch pipeline is communicated with the main through pipe and the second branch pipeline is not communicated with the main through pipe or the second branch pipeline is communicated with the main through pipe and the first branch pipeline is not communicated with the main through pipe, so that the treatment requirement of the single perfusion device parallel dialyzer is met. When the first branch pipeline and the second branch pipeline are sequentially communicated with the main through pipe, the first perfusion device and the second perfusion device are sequentially connected with the dialyzer in parallel, so that the treatment requirement of the dialyzer which is sequentially connected with the two perfusion devices in parallel is met. The sequential communication, namely the sequential communication, can be that the first branch pipeline is communicated with the main pipe firstly, then the second branch pipeline is communicated with the main pipe, or the second branch pipeline is communicated with the main pipe firstly, then the first branch pipeline is communicated with the main pipe, and the two branch pipelines can be selectively applied according to actual treatment needs. The communication pipeline can be communicated with the first branch pipeline and the second branch pipeline so that the first perfusion device is connected in series with the second perfusion device and then connected in parallel with the dialyzer. Through the communicating effect of the communicating pipeline, the blood purifying pipeline device can realize the treatment mode of the first perfusion device and the second perfusion device which are sequentially connected with the dialyzer in parallel, or the treatment mode of the first perfusion device which is connected with the dialyzer in parallel after being connected with the second perfusion device in series and the treatment mode of the single perfusion device which is connected with the dialyzer in parallel, thereby meeting the complex plasma treatment requirement. Medical staff can select a treatment mode of sequentially connecting the first perfusion device and the second perfusion device with the dialyzer in parallel or a treatment mode of connecting the first perfusion device with the dialyzer in parallel after connecting the first perfusion device with the second perfusion device in series or connecting the single perfusion device with the dialyzer in parallel according to actual treatment needs, so that open disassembly is avoided. The device has the advantages of simple structure, easy selection and application, simplified operation difficulty and capability of simultaneously meeting various use requirements of sequential perfusion treatment and parallel perfusion hemodialysis treatment.

Drawings

FIG. 1 is a schematic view of a blood purifying tube device according to an embodiment of the present invention;

fig. 2 is a schematic structural diagram of a blood purifying tube device according to a second embodiment of the present invention.

In the figure:

1. a main pipe;

2. a branch pipe assembly; 21. a first branch pipe; 22. a second branch pipe; 23. a communication pipeline; 231. a communicating main pipe; 232. a first branch pipe; 233. a second branch pipe; 24. a first perfusion apparatus; 25. a second perfusion apparatus; 261. a first switch; 262. a second switch; 263. a third switch; 264. a fourth switch; 265. a fifth switch; 266. a first perfusion switch; 267. a second perfusion switch; 268. a seventh switch; 269. an eighth switch;

3. a third emitter assembly; 31. a third perfusion apparatus; 32. a third pipeline; 321. an outlet switch; 33. a fourth pipeline; 331. an inlet switch;

4. reserving branch pipelines; 41. a reserved switch; 42. a luer; 43. hansen interface; 5. a waste liquid discharge branch pipeline; 51. a waste discharge switch; 6. a sixth switch;

71. a first sampling interface; 72. and a second sampling interface.

Detailed Description

The invention is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting thereof. It should be further noted that, for convenience of description, only some, but not all of the structures related to the present invention are shown in the drawings.

In the description of the present invention, unless explicitly stated and limited otherwise, the terms "connected," "connected," and "fixed" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communicated with the inside of two elements or the interaction relationship of the two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.

In the present invention, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.

In the description of the present embodiment, the terms "upper", "lower", "left", "right", and the like are orientation or positional relationships based on those shown in the drawings, merely for convenience of description and simplicity of operation, and do not indicate or imply that the apparatus or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the invention. Furthermore, the terms "first," "second," and the like, are used merely for distinguishing between descriptions and not for distinguishing between them.

In the description of the present embodiments, the terms "or" and/or "as used should be construed as inclusive or meaning any one or any combination. Thus, "A, B or C" or "A, B and/or C" means any one of the following: a, A is as follows; b, a step of preparing a composite material; c, performing operation; a and B; a and C; b and C; A. b and C. An exception to this definition will occur only when a combination of elements, functions, steps or acts are in some way inherently mutually exclusive.

Example 1

As shown in fig. 1, a first embodiment of the present invention provides a blood purifying line device, which includes a main tube 1 and a branch tube assembly 2. One end of the main through pipe 1 is used for communicating with an arterial line, and the other end is used for communicating with a dialyzer (not shown in the figure). The branch circuit assembly 2 includes a first branch circuit 21, a first perfusion apparatus 24, a second branch circuit 22, a second perfusion apparatus 25, and a communication circuit 23. The communication pipeline 23 is arranged between the first branch pipeline 21 and the second branch pipeline 22, the first perfusion device 24 is arranged on the first branch pipeline 21, and the second perfusion device 25 is arranged on the second branch pipeline 22. The first branch pipe 21 and the second branch pipe 22 can be selectively communicated with the main pipe 1 so that the first perfusion device 24 is connected with the dialyser in parallel, or the second perfusion device 25 is connected with the dialyser in parallel; that is, it is possible to realize that the first branch pipe 21 communicates with the main pipe 1 and the second branch pipe 22 does not communicate with the main pipe 1 or that the second branch pipe 22 communicates with the main pipe 1 and the first branch pipe 21 does not communicate with the main pipe 1, which is suitable for the treatment requirement of the single perfusion apparatus parallel dialyzer. When the first branch pipe 21 and the second branch pipe 22 are sequentially communicated with the main pipe 1, the first perfusion device 24 and the second perfusion device 25 are sequentially connected with the dialyzer in parallel, so that the treatment requirement of requiring two perfusion devices to be sequentially connected with the dialyzer in parallel is met. The first branch pipeline 21 and the second branch pipeline 22 are sequentially communicated with the main pipe 1, the first branch pipeline 21 is communicated with the main pipe 1 firstly, then the second branch pipeline 22 is communicated with the main pipe 1, the second branch pipeline 22 is communicated with the main pipe 1 firstly, then the first branch pipeline 21 is communicated with the main pipe 1, and the first branch pipeline 21 can be used selectively according to actual treatment requirements.

And the communication pipeline 23 can be used for communicating the first branch pipeline 21 with the second branch pipeline 22 so as to enable the first perfusion device 24 to be connected in series with the second perfusion device 25 and then connected in parallel with the dialyzer. Through the communicating effect of the communicating pipeline 23, the blood purifying pipeline device can realize the treatment mode of the first perfusion device 24 and the second perfusion device 25 which are sequentially connected with the dialyzer in parallel, or the treatment mode of the first perfusion device 24 which is connected with the second perfusion device 25 in series and then connected with the dialyzer in parallel and the treatment mode of the single perfusion device which is connected with the dialyzer in parallel can meet the complex plasma treatment requirement. Medical staff can select a treatment mode of the first perfusion device 24 and the second perfusion device 25 which are sequentially connected with the dialyzer in parallel or a treatment mode of the first perfusion device 24 which is connected with the second perfusion device 25 in series and then connected with the dialyzer in parallel or a single perfusion device which is connected with the dialyzer in parallel according to actual treatment needs, so that open disassembly is avoided. The device has the advantages of simple structure, easy selection and application, simplified operation difficulty and capability of simultaneously meeting various use requirements of sequential perfusion treatment and parallel perfusion hemodialysis treatment.

Preferably, the communication pipe 23 includes a communication main 231, a first branch 232, and a second branch 233. One end of the communication main pipe 231 is connected with the main pipe 1, the other end of the communication main pipe 231 is connected with the first branch pipe 232 and the second branch pipe 233, the other end of the first branch pipe 232, which is far away from the communication main pipe 231, is connected with the first branch pipe 21, and the other end of the second branch pipe 233, which is far away from the communication main pipe 231, is connected with the second branch pipe 22. Two of the main communication pipe 231, the first branch pipe 232 and the second branch pipe 233 are selectively communicated, so that three different treatment modes of connecting the first perfusion device 24 or the second perfusion device 25 in parallel with the dialyzer, connecting the first perfusion device 24 in series with the second perfusion device 25 and then connecting the first perfusion device 24 and the second perfusion device 25 in parallel with the dialyzer or connecting the first perfusion device 24 and the second perfusion device 25 in series with the dialyzer are realized. Specifically, when the communication main pipe 231 communicates with the first branch pipe 232, the first perfusion unit 24 is connected in parallel to the dialyzer; when the main communication pipe 231 is connected to the second branch pipe 233, the second perfusion device 25 is connected in parallel to the dialyzer, so that the first perfusion device 24 and the second perfusion device 25 can be connected in parallel to the dialyzer sequentially by controlling the sequence of the main communication pipe 231 for connecting the first branch pipe 232 and the second branch pipe 233. The sequential parallel connection can be that the first perfusion device 24 is connected in parallel with the dialyzer first and then the second perfusion device 25 is connected in parallel with the dialyzer second, or that the second perfusion device 25 is connected in parallel with the dialyzer first and then the perfusion device 24 is connected in parallel with the dialyzer first, and the sequential parallel connection can be selected and applied according to the actual treatment requirement. When the first branch pipe 232 is communicated with the second branch pipe 233, the first perfusion device 24 is connected in series with the second perfusion device 25 and then connected in parallel with the dialyzer, and the adjustment and control modes are simple.

As a preferred scheme, the first branch pipe 232 and the second branch pipe 233 are symmetrically arranged at two sides of the main communication pipe 231 to enable the main communication pipe 23 to be in a Y-shaped structure, the first branch pipe 21 and the second branch pipe 22 are symmetrically arranged at two sides of the main communication pipe 23 respectively to be connected with the first branch pipe 232 and the second branch pipe 233 respectively, the pipeline design is visual and clear, the communicated pipelines can be selected according to actual treatment needs, and the operation is simple and convenient in the use process of medical staff.

Preferably, the branch pipe assembly 2 further includes a first switch 261, a second switch 262 and a third switch 263, wherein the first switch 261 is disposed on the main communication pipe 231, and the second switch 262 is disposed on the first branch pipe 232 or the first branch pipe 21. Because the first branch pipe 21 is connected to the first branch pipe 232, the second switch 262 is disposed on the first branch pipe 232 or the first branch pipe 21, so as to control whether the blood flows through the first perfusion apparatus 24; similarly, since the second branch pipe 233 is connected to the second branch pipe 22, the third switch 263 is disposed on the second branch pipe 233 or the second branch pipe 22 to control whether the blood flows through the second perfusion apparatus 25.

Specifically, two of the first switch 261, the second switch 262, and the third switch 263 are selectively opened to selectively communicate two of the communication main 231, the first branch 232, and the second branch 233. When the first switch 261 and the second switch 262 are opened and the third switch 263 is closed, the communication main pipe 231 is communicated with the first branch pipe 21, and at this time, the first perfusion unit 24 is connected in parallel with the main pipe 1; when the first switch 261 and the third switch 263 are opened and the second switch 262 is closed, the communication main pipe 231 is communicated with the second branch pipe 22, and at this time, the second perfusion device 25 is connected in parallel with the main pipe 1; when the first switch 261 is turned off, the second switch 262 and the third switch 263 are turned on, the first branch pipe 21 is communicated with the second branch pipe 22, and the first perfusion unit 24 is connected in series with the second perfusion unit 25.

Preferably, the outlet end of the first perfusion apparatus 24 is connected to the first branch pipe 21, the inlet end is connected to the first branch pipe 232, and the second switch 262 is disposed on the first branch pipe 21; similarly, the inlet end of the second perfusion device 25 is connected with the second branch pipeline 22, the outlet end is connected with the second branch pipeline 233, the third switch 263 is arranged on the second branch pipeline 22, the structures of the first branch pipeline 21 and the second branch pipeline 22 are greatly simplified, the connection and installation of the structural components can be easily realized, and the operation is simple.

In the main pipe 1, a second branch pipe 22, a communication main pipe 231, and a first branch pipe 21 are provided in this order in the flow direction of the liquid. The branch pipe assembly 2 further includes a fourth switch 264 and a fifth switch 265 both disposed on the main pipe 1, the fourth switch 264 being located between the first branch pipe 21 and the main communication pipe 231, and the fifth switch 265 being located between the main communication pipe 231 and the second branch pipe 22. The flow direction of the blood or the pre-flushing normal saline can be controlled through the fourth switch 264 and the fifth switch 265, so that the blood or the pre-flushing normal saline does not flow through the main through pipe 1 when necessary, for example, when the first perfusion device 24 or the second perfusion device 25 is connected in parallel with the main through pipe 1, the fourth switch 264 and the fifth switch 265 are closed, the blood or the pre-flushing normal saline does not flow through the main through pipe 1 any more, and all the blood or the pre-flushing normal saline flows through the branch pipe assembly 2, so that the flow resistance is reduced.

Specifically, when the first perfusion apparatus 24 and the second perfusion apparatus 25 are required to be sequentially connected in parallel to the dialyzer in the treatment mode, for example, the first perfusion apparatus 24 is connected in parallel to the dialyzer and the second perfusion apparatus 25 first and then connected in parallel to the dialyzer, at this time, the fourth switch 264 and the third switch 263 are turned off first, the first switch 261, the second switch 262 and the fifth switch 265 are turned on, the second switch 262 and the fifth switch 265 are turned off after the treatment of the first perfusion apparatus 24 is completed, the first switch 261, the third switch 263 and the fourth switch 264 are turned on, and the first perfusion apparatus 24 after the treatment is completed is not required to be removed, thereby avoiding the open structure of the branch pipe assembly 2. Alternatively, in some treatment modes where the first and second perfusion units 24, 25 are not required, the first, second, and third switches 261, 262, 263 are closed and the fourth and fifth switches 264, 265 are opened. The method has the advantages that the hemodialysis and blood perfusion combined hemodialysis treatment mode can be switched randomly, a secondary disassembly pipeline and a perfusion device are not needed, the blood purification pipeline device is sealed in the whole process in the operation process, the risks of joint exposure, liquid dripping and air entering are avoided, the infection risk is greatly reduced, and the clinical operation time is effectively saved.

Of course, during the treatment process, only one of the first perfusion unit 24 and the second perfusion unit 25 may be used, for example, when CRRT (continuous kidney substitution therapy) or common dialysis combined HP treatment is performed, only the first perfusion unit 24 or the second perfusion unit 25 needs to be selected and connected in parallel with the dialyzer, and after the treatment of the first perfusion unit 24 or the second perfusion unit 25 is completed, the first perfusion unit 24 or the second perfusion unit 25 does not need to be disassembled, and the CRRT treatment can still be performed continuously through corresponding switch control.

As a preferred solution, the blood purification line device further comprises a reserved branch line 4, wherein the reserved branch line 4 is connected to the main tube 1. The liquid flow reserved branch pipeline 4 can be selectively communicated with the main through pipe 1, and the liquid can be supplemented or other pipelines can be connected through the reserved branch pipeline 4, so that the functions of the blood purification pipeline device are more various. Specifically, the communication of the reserved branch pipe 4 may be through a reserved switch 41 on the reserved branch pipe 4, or a three-way valve may be disposed at the connection between the reserved branch pipe 4 and the main pipe 1.

On a reserved branch pipeline 4 (refer to fig. 2), a luer 42 can be arranged, and the luer 42 is communicated with the middle of the pipelines of other treatment pipelines, so that the use is convenient; alternatively, the hansen interface 43 can be connected through the luer interface 42, and the other end of the hansen interface 43 can be connected with other dialyzer bypasses, so that the blood purifying tube device is applicable to complicated artificial liver treatment, and the functions of the blood purifying tube device are more various. In practical application, the reserved branch pipe 4 can be arranged at any position of the main pipe 1 according to the treatment requirement, and the figure is not limited by the embodiment.

In order to realize the pre-flushing function, the blood purification pipeline device further comprises a waste liquid discharge branch pipeline 5, wherein one end of the waste liquid discharge branch pipeline 5 is connected to the main through pipe 1, and the other end is connected to a waste liquid collecting structure (not shown in the figure). The waste liquid collecting structure may be an ultrafiltration waste liquid pipe or a waste liquid bag, and the embodiment is not particularly limited. Along the flow direction of the liquid flow, a waste liquid discharge branch pipe 5 is arranged at the downstream of the branch pipe assembly 2, and the waste liquid discharge branch pipe 5 can be selectively communicated with the main through pipe 1. The blood purification line arrangement further comprises a sixth switch 6, the sixth switch 6 being arranged on the main conduit 1, the sixth switch 6 being located downstream of the waste drain branch conduit 5 in the direction of flow of the liquid stream and upstream of the dialyzer. When the first perfusion device 24 and/or the second perfusion device 25 are/is pre-flushed, the sixth switch 6 is closed, and waste liquid generated by pre-flushing is discharged through the waste liquid discharge branch pipeline 5 without influencing the dialyzer. Preferably, the waste liquid discharge branch pipe 5 is further provided with a waste discharge switch 51, the waste discharge switch 51 is used for controlling the opening and closing of the waste liquid discharge branch pipe 5, and after the pre-flushing is finished, the waste discharge switch 51 can be closed, and the sixth switch 6 can be opened. The waste liquid collecting structure can be arranged in a separated mode through the waste discharging switch 51, and the use is convenient. In the subsequent treatment, it is necessary to keep the sixth switch 6 in the open state all the time.

When the pre-flushing function is used, the first perfusion unit 24 and the second perfusion unit 25 may be pre-flushed separately, and when the first perfusion unit 24 is pre-flushed separately, the fourth switch 264 and the third switch 263 may be closed, and the first switch 261, the second switch 262 and the fifth switch 265 may be opened; when the second perfusion unit 25 is pre-flushed separately, the fifth switch 265 and the second switch 262 are closed, and the first switch 261, the third switch 263 and the fourth switch 264 are opened. The first perfusion unit 24 and the second perfusion unit 25 can be pre-flushed simultaneously, at this time, the first switch 261, the fourth switch 264 and the fifth switch 265 are closed, and the second switch 262 and the third switch 263 are opened, so that the use is convenient.

In addition, although the waste branch pipe 5 is disposed downstream of the branch pipe assembly 2, there are cases where the flow does not pass through the first and second perfusion units 24 and 25, that is, the first, second and third switches 261, 262 and 263 are all closed, and the flow passes through the main pipe 1 directly into the waste branch pipe 5 when the pre-flushing function is used.

Preferably, the second switch 262 is disposed on the first branch pipe 21, the third switch 263 is disposed on the second branch pipe 22, the branch pipe assembly 2 further includes a first perfusion switch 266 and a second perfusion switch 267, the first perfusion switch 266 is disposed on the first branch pipe 232, and the second perfusion switch 267 is disposed on the second branch pipe 233. Therefore, the second switch 262 and the first perfusion switch 266 are respectively located at the outlet end and the inlet end of the first perfusion apparatus 24, the third switch 263 and the second perfusion switch 267 are respectively located at the outlet end and the outlet end of the second perfusion apparatus 25, when the first perfusion apparatus 24 and the second perfusion apparatus 25 are not needed to be used, the first perfusion switch 266 can ensure that the inlet end of the first perfusion apparatus 24 is closed, the second perfusion switch 267 can ensure that the outlet end of the second perfusion apparatus 25 is closed, and the first perfusion apparatus 24 and the second perfusion apparatus 25 can be completely isolated, thereby further improving the safety of the blood purification pipeline apparatus.

It should be noted that, the first switch 261, the second switch 262, the third switch 263, the fourth switch 264, the fifth switch 265, the sixth switch 6, the waste discharge switch 51, the first perfusion switch 266 and the second perfusion switch 267 can be directly clamped on a pipeline by clips, so that the on/off of the pipeline can be controlled, and the structure is simple and the use is convenient. In other embodiments, the first switch 261, the second switch 262, the third switch 263, the fourth switch 264, the fifth switch 265, the sixth switch 6, the waste discharge switch 51, the first perfusion switch 266 and the second perfusion switch 267 may be omitted, and three-way valves may be disposed at the intersection of the pipes, for example, at the junction of the main pipe 1 and the waste discharge branch pipe 5, at the junction of the main pipe 1 and the first branch pipe 21, at the junction of the main pipe 1 and the main pipe 231, at the junction of the main pipe 1 and the second branch pipe 22, and at the junction of the main pipe 231 and the first branch pipe 232 and the second branch pipe 233, respectively, so as to control the flow direction of the blood and the pre-flushing physiological saline. The specific structure and the pipeline control mode of the three-way valve can be set according to the prior art, and the description of the embodiment is omitted here.

Preferably, the main pipe 1 is provided with a first sampling interface 71 and a second sampling interface 72, and the first sampling interface 71 and the second sampling interface 72 are respectively located upstream and downstream of the branch pipe assembly 2 along the flow direction of the liquid flow. When the clinical treatment effect needs to be checked, the first sampling interface 71 and the second sampling interface 72 can be used for sampling respectively, and checking and comparing the sampled products, so as to check the treatment effect. The arrangement of the first sampling interface 71 and the second sampling interface 72 does not affect the integral structure of the pipeline, and is convenient to use.

Example two

As shown in fig. 2, the second embodiment provides a blood purifying line device having the main tube 1 and the branch tube assembly 2 of the first embodiment. The branch pipe assembly 2 comprises a first branch pipe 21, a second branch pipe 22 and a communication pipe 23, wherein the first branch pipe 21 and the second branch pipe 22 can be selectively communicated with the main pipe 1 so as to enable the first perfusion device 24 to be connected with the dialyser in parallel, or enable the second perfusion device 25 to be connected with the dialyser in parallel; the first perfusion device 24 is connected in parallel with the dialyzer by the first branch pipeline 21 being communicated with the main through pipe 1 and the second branch pipeline 22 being not communicated with the main through pipe 1, and the second perfusion device 25 is connected in parallel with the dialyzer by the second branch pipeline 22 being communicated with the main through pipe 1 and the first branch pipeline 21 being not communicated with the main through pipe 1, so that the treatment requirement of the single perfusion device parallel dialyzer is met. When the first branch pipe 21 and the second branch pipe 22 are sequentially communicated with the main pipe 1, the first perfusion device 24 and the second perfusion device 25 are sequentially connected with the dialyzer in parallel, so that the treatment requirement of requiring two perfusion devices to be sequentially connected with the dialyzer in parallel is met. And the communication pipeline 23 can be used for communicating the first branch pipeline 21 and the second branch pipeline 22 so that the first perfusion device 24 is connected in series with the second perfusion device 25 and then connected in parallel with the dialyzer.

The second embodiment also provides a blood purifying line device, which further includes a third perfusion unit 3, where the third perfusion unit 3 includes a third perfusion unit 31, and the dialyzer is selectively connected in parallel to the branch line unit 2 or the third perfusion unit 3. When the dialyzer is connected in parallel with the branch pipeline assembly 2, the first perfusion device 24 can be connected in parallel with the dialyzer, or the second perfusion device 25 can be connected in parallel with the dialyzer, or the first perfusion device 24 is connected in series with the second perfusion device 25 and then connected in parallel with the dialyzer; when the dialyzer is connected in parallel to the third emitter assembly 3, the dialyzer is connected in parallel to the third emitter 31. Different perfusion apparatus can have different types of adsorption columns, and the removal capacity of different toxins such as inflammatory medium, bilirubin and the like is different. In a complex treatment requirement requiring more than two perfusion apparatuses, the treatment requirement includes three perfusion apparatuses connected in parallel sequentially, and multiple treatment modes such as two perfusion apparatuses connected in series and a third perfusion apparatus 31 connected in parallel sequentially, which can be achieved by the blood purification pipeline apparatus provided in the second embodiment. The three perfusion devices can simultaneously meet the requirements of blood perfusion (HP)/blood Plasma Perfusion (PP), the pipeline connection is simple, and the clinical cost is greatly reduced.

Preferably, the third perfusion apparatus 3 further includes a third pipeline 32 and a fourth pipeline 33, one end of the third pipeline 32 is connected to the outlet end of the third perfusion apparatus 31, the other end is connected to the first pipeline 21, one end of the fourth pipeline 33 is connected to the inlet end of the third perfusion apparatus 31, and the other end is connected to the second pipeline 22.

Specifically, the first branch pipe 21 is provided with an opening to communicate with the third branch pipe 32, so that the first branch pipe 21 and the third branch pipe 32 together form a stable Y-shaped structure; similarly, the second branch pipe 22 is provided with an opening for communicating with the fourth branch pipe 33, so that the second branch pipe 22 and the fourth branch pipe 33 together form a stable Y-shaped structure. The third and fourth branch pipes 32 and 33 are provided with an outlet switch 321 and an inlet switch 331, respectively, to select whether or not the inlet and outlet ends of the third perfusion unit 31 communicate with the main pipe 1.

In order to improve the isolation between the third perfusion apparatus 31 and the first perfusion apparatus 24, the second perfusion apparatus 25, a seventh switch 268 is added between the first perfusion apparatus 24 and the third branch pipe 32 on the first branch pipe 21; accordingly, an eighth switch 269 is provided between the second perfusion apparatus 25 and the fourth perfusion apparatus 33 on the second perfusion apparatus 22, so that blood or pre-flushing physiological saline is prevented from entering the first perfusion apparatus 24 and the second perfusion apparatus 25 during use or pre-flushing of the third perfusion apparatus 31, and reliability of the blood purification apparatus is improved.

It is to be understood that the above examples of the present invention are provided for clarity of illustration only and are not limiting of the embodiments of the present invention. Various obvious changes, rearrangements and substitutions can be made by those skilled in the art without departing from the scope of the invention. It is not necessary here nor is it exhaustive of all embodiments. Any modification, equivalent replacement, improvement, etc. which come within the spirit and principles of the invention are desired to be protected by the following claims.

Claims (10)

1. A blood purification circuit device, comprising:

one end of the main through pipe (1) is used for being communicated with an arterial pipeline, and the other end of the main through pipe (1) is used for being communicated with a dialyzer;

a branch pipe assembly (2), the branch pipe assembly (2) comprises a first branch pipe (21), a first perfusion device (24), a second branch pipe (22), a second perfusion device (25) and a communication pipe (23), the communication pipe (23) is arranged between the first branch pipe (21) and the second branch pipe (22), the first perfusion device (24) is arranged on the first branch pipe (21), the second perfusion device (25) is arranged on the second branch pipe (22), the first branch pipe (21) and the second branch pipe (22) can be selectively communicated with the main pipe (1) so that the first perfusion device (24) is connected with the dialyzer in parallel, or the second perfusion device (25) is connected with the dialyzer in parallel, or the first perfusion device (24) and the second perfusion device (25) are sequentially connected with the dialyzer in parallel;

the communication pipeline (23) can be used for communicating the first branch pipeline (21) and the second branch pipeline (22) so that the first perfusion device (24) is connected in series with the second perfusion device (25) and then connected in parallel with the dialyzer.

2. The blood purification line device according to claim 1, wherein the communication line (23) includes a communication main pipe (231), a first branch pipe (232) and a second branch pipe (233), one end of the communication main pipe (231) is connected to the main pipe (1), the other end is connected to the first branch pipe (232) and the second branch pipe (233), the other end of the first branch pipe (232) away from the communication main pipe (231) is connected to the first branch pipe (21), and the other end of the second branch pipe (233) away from the communication main pipe (231) is connected to the second branch pipe (22); and two of the communication main pipe (231), the first branch pipe (232) and the second branch pipe (233) are selectively communicated.

3. The blood purification tube device according to claim 2, wherein the first branch tube (232) and the second branch tube (233) are symmetrically disposed at both sides of the main communication tube (231) so that the communication tube (23) has a Y-shaped structure, and the first branch tube (21) and the second branch tube (22) are symmetrically disposed at both sides of the communication tube (23) respectively so as to connect the first branch tube (232) and the second branch tube (233) respectively.

4. The blood purification line set according to claim 2, wherein the branch line set (2) further includes a first switch (261), a second switch (262) and a third switch (263), the first switch (261) is provided on the communication main pipe (231), the second switch (262) is provided on the first branch pipe (232) or the first branch line (21), the third switch (263) is provided on the second branch pipe (233) or the second branch line (22), and two of the first switch (261), the second switch (262) and the third switch (263) are selectively opened to selectively communicate two of the communication main pipe (231), the first branch pipe (232) and the second branch pipe (233).

5. The blood purification line device according to claim 4, wherein an outlet end of the first perfusion apparatus (24) is connected to the first branch line (21), an inlet end is connected to the first branch line (232), and the second switch (262) is disposed on the first branch line (21); and/or the number of the groups of groups,

the inlet end of the second perfusion device (25) is connected with the second branch pipeline (22), the outlet end of the second perfusion device is connected with the second branch pipeline (233), and the third switch (263) is arranged on the second branch pipeline (22).

6. The blood purification line set according to claim 5, wherein the second branch line (22), the communication main pipe (231) and the first branch line (21) are sequentially disposed on the main pipe (1) in a flow direction of the liquid, the branch line assembly (2) further includes a fourth switch (264) and a fifth switch (265) each disposed on the main pipe (1), the fourth switch (264) being located between the first branch line (21) and the communication main pipe (231), and the fifth switch (265) being located between the communication main pipe (231) and the second branch line (22).

7. The blood purification tubing set according to claim 5, wherein the second switch (262) is disposed on the first branch tube (21), the third switch (263) is disposed on the second branch tube (22), the branch tube assembly (2) further comprises a first perfusion switch (266) and a second perfusion switch (267), the first perfusion switch (266) is disposed on the first branch tube (232), and the second perfusion switch (267) is disposed on the second branch tube (233).

8. The blood purification tubing set according to claim 1, further comprising a third perfusion assembly (3), the third perfusion assembly (3) comprising a third perfusion (31), the dialyzer being selectively connected in parallel to the branch tubing assembly (2) or the third perfusion assembly (3).

9. The blood purification tubing set according to claim 8, wherein the third perfusion assembly (3) further comprises a third branch tube (32) and a fourth branch tube (33), one end of the third branch tube (32) is connected to the outlet end of the third perfusion (31), the other end is connected to the first branch tube (21), one end of the fourth branch tube (33) is connected to the inlet end of the third perfusion (31), and the other end is connected to the second branch tube (22).

10. The blood purification line device according to any one of claims 1-9, further comprising a reserve branch line (4), said reserve branch line (4) being connected to said main conduit (1), said reserve branch line (4) being capable of selectively communicating with said main conduit (1); and/or the number of the groups of groups,

the blood purification pipeline device further comprises a waste liquid discharge branch pipeline (5), one end of the waste liquid discharge branch pipeline (5) is connected with the main through pipe (1), the other end of the waste liquid discharge branch pipeline is connected with a waste liquid collecting structure, and the waste liquid discharge branch pipeline (5) can be selectively communicated with the main through pipe (1); the blood purification pipeline device further comprises a sixth switch (6), the sixth switch (6) is arranged on the main through pipe (1), and the sixth switch (6) is positioned at the downstream of the waste liquid discharge branch pipeline (5) along the flowing direction of liquid flow; and/or the number of the groups of groups,

the main pipe (1) is provided with a first sampling interface (71) and a second sampling interface (72), and the first sampling interface (71) and the second sampling interface (72) are respectively positioned at the upstream and the downstream of the branch pipe assembly (2) along the flow direction of liquid flow.