CN117771462B - Bone marrow extraction equipment - Google Patents

Bone marrow extraction equipment Download PDF

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Publication number
CN117771462B
CN117771462B CN202410206603.0A CN202410206603A CN117771462B CN 117771462 B CN117771462 B CN 117771462B CN 202410206603 A CN202410206603 A CN 202410206603A CN 117771462 B CN117771462 B CN 117771462B
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blood
fluid
flow control
stem cell
blocking
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CN117771462A (en
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胡青
潘攀
向兵
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West China Hospital of Sichuan University
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West China Hospital of Sichuan University
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Abstract

The invention relates to the technical field of bone marrow extraction, and discloses bone marrow extraction equipment which comprises a stem cell separator main body, a blood pumping tube, a blood return tube, a fluid supplementing mechanism, a flow control mechanism and a blocking mechanism, wherein the stem cell separator main body is provided with a separating case, the fluid supplementing mechanism is arranged on one side of the separating case, a plurality of drip bags are arranged above the separating case and are respectively used for containing body fluid and microelements, the drip bags are connected with the fluid supplementing mechanism through drip infusion tubes, the flow control mechanism is arranged on the fluid supplementing mechanism and is used for controlling the output quantity of each drip bag, the output end of the blood pumping tube is connected with the stem cell separator main body, the blocking mechanism is arranged on the fluid supplementing mechanism, and the input end of the blood return tube is connected with the stem cell separator main body. The invention can regulate the amount of the body fluid and microelements during the blood drawing and returning process.

Description

Bone marrow extraction equipment
Technical Field
The invention relates to the technical field of bone marrow aspiration, in particular to bone marrow aspiration equipment.
Background
Hematopoietic stem cell donation, also known as bone marrow donation. The hematopoietic stem cell harvester collects hematopoietic stem cells from the peripheral blood of the donor by the machine and delivers the hematopoietic stem cells into the body of the recipient. During the collection process, the number of the collected hematopoietic stem cells and the collection times need to be determined according to the condition and the weight of the recipient. The collected hematopoietic stem cells can be used for treating various diseases, such as leukemia, lymphoma, aplastic anemia and the like.
When donating hematopoietic stem cells, medical personnel can prick the transfusion needle respectively on two arms of donator, and donator's blood continuously gets into the separating centrifuge from the blood drawing end, and blood is through the required stem cells of centrifugal separation collection, and the remaining blood is back to donator. However, the separator needs time to separate stem cells, the early blood is largely withdrawn but cannot return, body fluid and required microelements are needed to be timely supplemented into the body of the donor so as to ensure the safety of the donor, but when the body fluid is supplemented to the donor through the drip bottle, medical staff is required to manually control the amount of the body fluid and the elements according to the blood withdrawal amount, on one hand, the operation of the medical staff is inconvenient, and on the other hand, the ratio of the body fluid and the microelements which are supplemented is required to be controlled by the medical staff according to naked eyes and experience, and the phenomenon that the control of the medical staff is inaccurate can occur.
Disclosure of Invention
The invention provides a bone marrow extraction device which can conveniently regulate the amount of body fluid and microelements during blood drawing and blood return.
In order to achieve the technical purpose, the invention adopts the following technical scheme:
The utility model provides a marrow extraction equipment, including stem cell separating centrifuge main part, the blood pump, the return vessel, fluid infusion mechanism, accuse flow mechanism, blocking mechanism, be equipped with the separation machine case in the stem cell separating centrifuge main part, fluid infusion mechanism sets up in separation machine case one side, separation machine case top is equipped with a plurality of drip bags, be used for holding body fluid, microelement respectively, drip bag passes through drip infusion tube and connects fluid infusion mechanism, accuse flow mechanism sets up on fluid infusion mechanism for the output of each drip bag is controlled, stem cell separating centrifuge main part is connected to the output of blood pump, blocking mechanism sets up on fluid infusion mechanism, stem cell separating centrifuge main part is connected to the input of return vessel.
Further, a medicine hanging frame is arranged above the separating machine case, and the drip bag is hung on the medicine hanging frame.
Further, the fluid infusion mechanism comprises a mixing cartridge, the mixing cartridge is connected with the separator case through a fixed ring, a mixing chamber is arranged at the lower part in the mixing cartridge, at least two liquid outlet hoses are arranged at the upper part of the mixing cartridge, one end of each liquid outlet hose is connected with the mixing chamber, the other end of each liquid outlet hose is connected with a drip infusion tube, and the lower end of each mixing chamber is connected with the fluid infusion tube.
Furthermore, one side of the fluid infusion tube is provided with a connecting tube connected with the blood suction tube, and the blood suction tube, the connecting tube and the fluid infusion tube are not communicated with each other.
Further, the flow control mechanism comprises flow control columns, each liquid outlet hose is sleeved with one flow control column, an expansion gas ring is arranged inside the flow control column, one end of a gas transmission hose is externally connected with the expansion gas ring, the other end of the gas transmission hose is connected with a gas box, a first extrusion sheet and a second extrusion sheet are respectively arranged on two sides of the gas box, an electromagnet is arranged on the outer side of the first extrusion sheet, and the electromagnet is electrically connected with the stem cell separator body.
Further, blocking mechanism includes the buffer tank, and the buffer tank is inside to be equipped with and blocks the body, blocks the body top and is connected with and act as go-between two, and the expansion end of acting as go-between two passes upper portion blood drawing tube and rolls up on the take-up reel, and the take-up reel is connected the manual dish that sets up at the buffer tank outer wall.
Furthermore, the blocking body is shuttle-shaped, a backflow chamber is arranged in the blocking body, and a plurality of wall punching holes communicated with the backflow chamber are formed in the outer wall of the blocking body.
Further, the winding roll is further provided with a contraction wire in a winding mode, the contraction wire penetrates through the connecting pipe to be connected with the liquid supplementing mechanism, the end head of the contraction wire is provided with a limiting ring, and the contraction wire penetrates through the limiting ring to be wound on the liquid outlet hose to form a movable buckle structure.
Furthermore, a liquid flushing pipe is fixedly arranged on one side of the buffer tank.
Further, the inner wall of the flow control column is provided with an extrusion pad fixedly connected with the expansion gas ring, and the contraction wire is wound on the outer wall of the extrusion pad.
Compared with the prior art, the invention has the beneficial effects that:
The invention can be used for extracting the blood of the bone marrow donator and separating stem cells, can control the quantity of supplementing liquid and various microelements required for the donator body according to the working time period by the liquid supplementing mechanism and the flow control mechanism, and can timely block the output of body fluid and microelements after the blood extraction is finished, thereby being beneficial to ensuring the comfort and safety of the donator body and facilitating the operation of medical staff.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic view of the structure of the air box of the present invention;
FIG. 3 is a schematic view of the interior of the mixing cartridge of the present invention;
FIG. 4 is an enlarged schematic view of portion A of FIG. 3;
FIG. 5 is a schematic view of the structure of the inside of the flow control column according to the present invention;
FIG. 6 is a schematic view of the structure of the squeeze pad of the present invention;
FIG. 7 is a schematic view of the structure of the inside of the surge tank of the present invention;
FIG. 8 is a schematic view of the structure of the blocking mechanism plane of the present invention;
In the figure: 1-a stem cell separator body; 11-separating the chassis; 12-a medicine hanging frame; 13-drip bag; 14-drip infusion tube; 2-a fluid supplementing mechanism; 21-a fixing ring; 22-mixing cartridge; 23-a gas hose; 24-electromagnet; 25-pressing the first sheet; 26-an air box; 27-extruding the second sheet; 28-a fluid supplementing pipe; 29-vascular aspiration; 30-return of blood vessels; 201-connecting a pipe; 202-a medicine mixing chamber; 3-a flow control mechanism; 31-a flow control column; 32-a liquid outlet hose; 33-expanding the gas ring; 34-squeeze pads; 4-blocking mechanism; 41-a buffer tank; 42-flushing pipe; 43-a manual control panel; 44-blocker; 46-a second stay wire; 47-winding roll; 48-a reflow chamber; 49-punching wall holes; 401-shrink threads; 402-stop collar.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments of the present application. The components of the embodiments of the present application generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
In the description of the embodiments of the present application, it should be noted that, the indicated orientation or positional relationship is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship conventionally put in place when the product of this application is used, or the orientation or positional relationship conventionally understood by those skilled in the art, is merely for convenience of describing the present application and simplifying the description, and is not indicative or implying that the apparatus or element referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.
In the description of the embodiments of the present application, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; may be directly connected or indirectly connected through an intermediate medium. The specific meaning of the above terms in the present application will be understood in specific cases by those of ordinary skill in the art.
As shown in fig. 1 to 4, a bone marrow aspiration device comprises a stem cell separator body 1, a blood drawing tube 29, a blood return tube 30, a fluid infusion mechanism 2, a flow control mechanism 3 and a blocking mechanism 4; the stem cell separator main body 1 comprises a separator case 11, a medicine hanging frame 12 is arranged above the separator case 11, a plurality of drip bags 13 are hung on the medicine hanging frame 12 and are respectively used for containing body fluid and various microelements, the drip bags 13 are connected with a fluid supplementing mechanism 2 through drip infusion tubes 14, the output end of a blood pumping tube is connected with the stem cell separator main body 1, and the input end of a blood return tube 30 is connected with the stem cell separator main body 1.
As shown in fig. 1-4, the fluid infusion mechanism 2 comprises a mixing cartridge 22, the mixing cartridge 22 is connected with a separator 11 through a fixing ring 21, a mixing chamber 202 is arranged at the lower part in the mixing cartridge 22, at least two liquid outlet hoses 32 are arranged at the upper part, one end of each liquid outlet hose 32 is connected with the mixing chamber 202, the other end of each liquid outlet hose 32 is connected with a drip infusion tube 14, the lower end of each mixing chamber 202 is connected with a fluid infusion tube 28, and liquid in a drip bag 13 flows into the mixing cartridge 22 through each liquid outlet hose 32, and is input into a donator after being mixed. One side of the fluid infusion tube 28 is provided with a connecting tube 201 which is connected with a blood suction tube 29, the connecting tube 201 and the fluid infusion tube 28 are not communicated with each other, and the output end of the blood suction tube 29 is connected with the stem cell separator main body 1. When the invention is used for stem cell separation of bone marrow donors, two infusion needles are inserted into two arms of the donor, one infusion needle is connected with the input end of a blood pumping tube 29, the other infusion needle is a double-head retaining needle and is respectively connected with the output end of a fluid supplementing tube 28 and the output end of a blood return tube 30, blood pumped by the blood pumping tube 29 flows into a stem cell separator main body 1 for stem cell separation, and meanwhile, the amounts of supplementing liquid and various microelements required are regulated according to the working time period of the stem cell separator main body 1. When the blood is extracted but not refluxed, the flow control mechanism 3 controls the drip bag 13 to increase the output quantity of body fluid and microelements, and when the blood is extracted and refluxed, the flow control mechanism 3 controls the drip bag 13 to decrease the output quantity of body fluid and microelements; when the blood drawing is finished but the blood is still in a reflux state, the blocking mechanism 4 can block the blood drawing and the fluid infusion.
As shown in fig. 1-2 and fig. 4-5, the flow control mechanism 3 is used for controlling the output quantity of each drip bag 13, and comprises a flow control column 31, each liquid outlet hose 32 is sleeved with one flow control column 31, an expansion air ring 33 is arranged inside the flow control column 31, one end of the air hose 23 is externally connected with the expansion air ring 33, and the other end of the air hose 23 is connected with an air supply assembly. When body fluid and different microelements flow through the flow control mechanism 3, the inflation gas ring 33 is inflated by injecting gas into the inflation gas ring 33, so that the liquid flow rate of the liquid outlet hose 32 is controlled, the mixing proportion of the body fluid and the microelement liquid can be controlled, the microelements and the body fluid which are input into the human body are ensured to be always suitable for the body of a donor, and the change along with the time is beneficial to ensuring the safety of the donor. Preferably, the cross section of the expansion gas ring 33 is isosceles trapezoid, the inner side is an upper bottom, and the outer side is a lower bottom. The air supply assembly comprises an air box 26, an electromagnet 24, a first extrusion sheet 25 and a second extrusion sheet 27, wherein the first extrusion sheet 25 and the second extrusion sheet 27 are respectively arranged on two sides of the air box 26, the electromagnet 24 is arranged on the outer side of the first extrusion sheet 25, and the electromagnet 24 is electrically connected with the stem cell separator body 1. In this embodiment, four sets of air supply assemblies and two liquid outlet hoses 32 are provided, each expansion air ring 33 is respectively connected with two sets of air supply assemblies, an intelligent control system is arranged in the separator case 11, and can control the operation of the electromagnet 24, so that the electromagnet 24 can generate repulsive force to the first extrusion sheet 25, the first extrusion sheet 25 is pushed to extrude the air box 26, air in the air box 26 enters the expansion air ring 33 from the air transmission hose 23, and the expansion air ring 33 expands and compresses the liquid outlet hose 32, thereby controlling the flow rate of liquid. The amount of gas stored in each set of gas cells 26 may be the same or different, e.g., the amount of body fluid output is generally greater than the amount of trace elements output, and thus the associated inflation gas ring 33 is less inflated and requires less air. In actual operation, the drawn blood needs to be separated from stem cells through each pipeline in the stem cell separator main body 1, and in the initial stage, a large amount of blood is drawn before the blood starts to flow back into the patient, so that body fluid needs to be quickly and largely supplemented into the donor to ensure the safety of the donor, and trace elements such as calcium elements which need to be supplemented at the moment are not very much, the flow rate of a liquid outlet hose 32 which needs to be communicated with the body fluid is accelerated, the flow rate of the liquid outlet hose 32 for supplementing the calcium elements is slowed down, the thickness of the liquid outlet hose 32 is controlled through an expansion gas ring 33, the flow rate of the liquid is controlled, the body fluid supplement of the donor is regulated along with time change, and the safety of the donor is ensured.
As shown in fig. 1-2, fig. 4 and fig. 6-8, the blocking mechanism 4 is used for blocking the blood drawing tube 29 and the liquid outlet hose 32, and comprises a buffer tank 41, a blocking body 44 is arranged in the buffer tank 41, a second pull wire 46 is connected to the top of the blocking body 44, the movable end of the second pull wire 46 passes through the upper blood drawing tube 29 and is wound on a winding roll 47, and the winding roll 47 is connected with a manual control disc 43 arranged on the outer wall of the buffer tank 41. The winding roll 47 is also wound with a contraction wire 401, the contraction wire 401 passes through the connecting pipe 201 to be connected with the fluid infusion mechanism 2, the end of the contraction wire 401 is provided with a limiting ring 402, and the contraction wire 401 passes through the limiting ring 402 to be wound on the liquid outlet hose 32 to form a movable buckle structure. Preferably, the inner wall of the flow control column 31 is provided with a squeezing pad 34 fixedly connected with the expansion gas ring 33, the squeezing pad 34 is tightly attached to the outer wall of the liquid outlet hose 32, and the shrinkage wire 401 passes through the limiting ring 402 and is wound on the outer wall of the squeezing pad 34, so that the liquid outlet hose 32 is prevented from being damaged. The blocking body 44 is in a shuttle shape, a backflow chamber 48 is arranged in the blocking body 44, and a plurality of wall punching holes 49 communicated with the backflow chamber 48 are formed in the outer wall of the blocking body 44. A flushing pipe 42 is fixedly provided at one side of the buffer tank 41. When donation is completed, the manual control disc 43 is rotated to roll the second stay wire 46 and the shrinkage wire 401, the second stay wire 46 pulls the blocking body 44 to ascend to block the blood pumping tube 29, meanwhile, the shrinkage wire 401 is tightened to enable the liquid outlet hose 32 to be closed, the liquid supplementing to the donator is stopped timely, after blood completely flows back into the donator, medical staff injects liquid medicine into the liquid flushing tube 42 through the injector to flush residual blood in the buffer tank 41 back into the donator, meanwhile, the liquid medicine can be flushed into the backflow chamber 48, and then the backflow chamber 48 sprays the liquid medicine into the buffer tank 41 along the wall flushing hole 49, so that the effect of flushing the buffer tank 41 is achieved.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (2)

1. A bone marrow aspiration device, characterized by: the blood-taking and blood-supplementing device comprises a stem cell separator body (1), a blood-taking pipe (29), blood return pipes (30), a fluid supplementing mechanism (2), a flow control mechanism (3) and a blocking mechanism (4), wherein a separating machine case (11) is arranged on the stem cell separator body (1), the fluid supplementing mechanism (2) is arranged on one side of the separating machine case (11), a plurality of drip bags (13) are arranged above the separating machine case (11) and are respectively used for containing body fluid and trace elements, the drip bags (13) are connected with the fluid supplementing mechanism (2) through drip infusion pipes (14), the flow control mechanism (3) is arranged on the fluid supplementing mechanism (2) and is used for controlling output quantity of each drip bag (13), an output end of the blood taking pipe is connected with the stem cell separator body (1), the blocking mechanism (4) is arranged on the blood-taking pipe (29), and an input end of the blood return pipe (30) is connected with the stem cell separator body (1);
The liquid supplementing mechanism (2) comprises a mixing tube (22), the mixing tube (22) is connected with the separating machine case (11) through a fixing ring (21), a mixing chamber (202) is arranged at the lower part in the mixing tube (22), at least two liquid outlet hoses (32) are arranged at the upper part, one end of each liquid outlet hose (32) is connected with the mixing chamber (202), the other end of each liquid outlet hose is connected with the drip infusion tube (14), and the lower end of each mixing chamber (202) is connected with the corresponding liquid supplementing tube (28);
The flow control mechanism (3) comprises flow control columns (31), each liquid outlet hose (32) is sleeved with one flow control column (31), an expansion gas ring (33) is arranged inside the flow control column (31), one end of a gas transmission hose (23) is externally connected with the expansion gas ring (33), the other end of the gas transmission hose (23) is connected with a gas box (26), two sides of the gas box (26) are respectively provided with a first extrusion sheet (25) and a second extrusion sheet (27), an electromagnet (24) is arranged outside the first extrusion sheet (25), and the electromagnet (24) is electrically connected with the stem cell separator main body (1);
the blocking mechanism (4) comprises a buffer tank (41), a blocking body (44) is arranged in the buffer tank (41), a second stay wire (46) is connected to the top of the blocking body (44), the movable end of the second stay wire (46) passes through the upper blood drawing tube (29) and is wound on a winding roll (47), and the winding roll (47) is connected with a manual control disc (43) arranged on the outer wall of the buffer tank (41);
The blocking body (44) is in a shuttle shape, a reflux chamber (48) is arranged in the blocking body (44), and a plurality of wall punching holes (49) communicated with the reflux chamber (48) are formed in the outer wall of the blocking body (44); the top wall of the blocking body (44) is closed, an opening at the bottom of the blocking body (44) is communicated with the backflow chamber (48), a wall punching hole (49) is formed in the side wall of the blocking body (44), a flushing pipe (42) is fixedly arranged on one side of the buffer tank (41), and the flushing pipe (42) is communicated with the inside of the buffer tank (41);
The winding roll (47) is also provided with a contraction wire (401), the contraction wire (401) is connected with a fluid infusion mechanism (2), the end of the contraction wire (401) is provided with a limiting ring (402), the contraction wire (401) passes through the limiting ring (402) and is wound on the fluid outlet hose (32), the manual control disc (43) is rotated to wind the second pull wire (46) and the contraction wire (401), the second pull wire (46) pulls the blocking body (44) to ascend to block the blood suction tube (29), and meanwhile, the contraction wire (401) is tightened to seal the fluid outlet hose (32);
the inner wall of the flow control column (31) is provided with an extrusion pad (34) fixedly connected with the expansion gas ring (33), and the contraction wire (401) is wound on the outer wall of the extrusion pad (34).
2. The bone marrow aspiration device of claim 1, wherein: a medicine hanging frame (12) is arranged above the separation machine case (11), and a drip bag (13) is hung on the medicine hanging frame (12).
CN202410206603.0A 2024-02-26 2024-02-26 Bone marrow extraction equipment Active CN117771462B (en)

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CN219770387U (en) * 2023-03-13 2023-09-29 四川大学华西医院 Device convenient for sticking label of blood collection tube
CN117018321A (en) * 2023-06-30 2023-11-10 南通市第一老年病医院(上海大学附属南通医院、南通市第六人民医院、南通市肺科医院) Clysis equipment
CN117243827A (en) * 2023-09-27 2023-12-19 贵州省第二人民医院 Severe clinical liquid food feeding equipment

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