CN117717534A - Coating preparation for rumen dissolution of ruminant after rumen bypass and application thereof - Google Patents
Coating preparation for rumen dissolution of ruminant after rumen bypass and application thereof Download PDFInfo
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- CN117717534A CN117717534A CN202410176129.1A CN202410176129A CN117717534A CN 117717534 A CN117717534 A CN 117717534A CN 202410176129 A CN202410176129 A CN 202410176129A CN 117717534 A CN117717534 A CN 117717534A
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Landscapes
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Abstract
The invention provides a coating preparation for rumen dissolution after rumen bypass of ruminant animals and application thereof, wherein the coating preparation comprises a core material and a coating, and the coating is prepared from coating liquid; the coating liquid comprises the following components: adding polyacrylic resin into absolute ethyl alcohol, uniformly mixing to form a solution, adding a film forming auxiliary agent, and obtaining the film forming auxiliary agent after the materials are completely melted; the film forming agent comprises 6 parts by mass of polyacrylic resin and 6-24 parts by mass of film forming agent, wherein the film forming agent is vegetable phospholipid. The coating preparation provided by the invention adopts the polyacrylic resin IV and ethanol to be mixed to form the solution, and the plant phospholipid is fully mixed with the solution after being heated and melted, so that the preparation method is simple and controllable, does not need too high temperature, is beneficial to safe production, has short production period and is suitable for large-scale production.
Description
Technical Field
The invention belongs to the technical field of animal feed, and particularly relates to a coating preparation for rumen dissolution of ruminants after rumen bypass and application thereof.
Background
Ruminants are different from other monogastric animals in the digestive tract structure, and most of the ruminants have developed rumen for fermenting roughage to provide nutrient substances for animal bodies, but rich microorganisms in the rumen can degrade various high-value nutrient components, such as plant extracts, amino acids, vitamins and the like, so that nutrient loss is caused, and the utilization efficiency of the animal bodies is reduced. For this reason, ruminant rumen bypass products have been developed to avoid degradation of feed nutrients by rumen microorganisms. Common rumen bypass production techniques include saponification, hydrogenation, maillard reactions, and coating.
The rumen bypass coating is characterized in that a layer of relatively stable coating material is uniformly coated on the surface of the pellet feed through a coating technology, so that the pellet feed is prevented from being degraded by microorganisms, and the rumen bypass efficiency of the core-spun pellet is improved. The rumen bypass coating is suitable for coating which needs to be dissolved in abomasum or intestinal tract, the coating preparation needs to be kept stable in digestive juice such as rumen juice (pH value is 5.5-7.0), and core materials are released by dissolving gastric acid or intestinal solution (pH value is 7.0-8.7) in abomasum (pH value is 0.9-1.5) after passing through the rumen; the enteric coating also needs to remain stable in the abomasum of the ruminant, after which the core material is released by dissolution in the alkaline environment of the intestinal solution.
The existing rumen bypass coating preparation mainly comprises saturated fatty acid or fatty alcohol coating materials, but the coating does not have wear resistance, and the coating is damaged due to friction with roughage in the ruminant process, so that the core material is released in the rumen; another class includes macromolecular polymeric coating materials, commonly used including polyacrylic resins, which increase the cost and risk of the coating due to the large amounts of ethanol required for its film formation and the high temperatures of melting.
Patent CN115152900A discloses a rumen bypass coating preparation, a preparation method and application thereof, wherein polyacrylic resin III, absolute ethyl alcohol and solid grease are adopted to prepare the coating preparation, and the coating preparation needs to be heated to 90-110 ℃ in the production process, so that more energy is consumed; the release rate of the coated guanidinoacetic acid in artificial rumen fluid is 16%, and the rumen bypass efficiency is required to be improved.
Patent CN106798094a discloses a process of mixing saturated fatty acid with polyacrylic resin by melting at high temperature, but saturated fatty acid is insoluble in ethanol and polyacrylic resin, and the film forming effect is reduced after mixing. Some techniques use tributyl citrate as a plasticizer along with polyacrylic resin as a coating material to improve film formation, but tributyl citrate may be harmful to animal health, including liver, kidney and central nervous system effects. There is therefore a need to develop new plasticising materials.
Disclosure of Invention
Aiming at the defects existing in the prior art, the invention aims to provide a coating preparation for rumen bypass dissolution of ruminants, and a rumen bypass product with better performance is obtained at lower cost.
It is a further object of the present invention to propose the use of said coating formulation.
The technical scheme for realizing the purposes of the invention is as follows:
a coating preparation for rumen dissolution of ruminant after rumen bypass comprises a core material and a coating, wherein the coating is prepared from coating liquid; the coating liquid comprises the following components: adding polyacrylic resin into absolute ethyl alcohol, uniformly mixing to form a solution, adding a film forming auxiliary agent, and obtaining the film forming auxiliary agent after the materials are completely melted; the film forming agent comprises 6 parts by mass of polyacrylic resin and 6-24 parts by mass of film forming agent, wherein the film forming agent is vegetable phospholipid.
The polyacrylic resin is polyacrylic resin III or polyacrylic resin IV, and the plant phospholipid is phospholipid byproduct obtained after oil plants leach oil or purified phospholipid, and is one or more selected from soybean phospholipid, sunflower seed phospholipid, peanut phospholipid and corn phospholipid.
The present inventors have tested vegetable oils when selecting film forming aids and tested with hydrogenated palm oil and the like, but found that hydrogenated palm oil has poor film forming properties in the test, and shows poor compatibility with polyacrylic resins, and has poor rumen protection effect on cores as coating materials. The phospholipid in the lipid contains hydrophobic and hydrophilic groups, can be dissolved in ethanol, and the similar compatibility increases the film forming property of the polyacrylic resin dissolved in ethanol, so that the film forming effect is better than that of using saturated fatty acid to protect the core material from being degraded by rumen microorganisms. The phospholipid has energy, cell membrane components, emulsifier action, cardiovascular effect improvement and the like on animal organisms, and the phospholipid is used as the rumen bypass coating material for the first time, so that the film forming property of the film is improved, the dosage of the coating material polyacrylic resin is reduced, and the production cost of the rumen bypass product is saved.
The preparation method of the coating liquid comprises the following steps: and mixing the polyacrylic resin with absolute ethyl alcohol to form a polyacrylic resin solution, heating the plant phospholipid to 60-80 ℃, adding the polyacrylic resin solution after the materials are melted, and stirring and uniformly mixing to obtain the modified polyacrylic resin.
The preparation method of the coating liquid comprises the following steps: and mixing 6 parts by mass of polyacrylic resin with 7-10 parts by mass of absolute ethyl alcohol to form polyacrylic resin solution, heating 10-16 parts by mass of vegetable phospholipids to 60-80 ℃, adding the polyacrylic resin solution after the materials are melted, and stirring and uniformly mixing to obtain the polyacrylic resin.
Among the vegetable phospholipids, soybean phospholipids are more preferable. The soybean lecithin is a product extracted from oil residue in the production of soybean oil, mainly contains lecithin, cephalin, inositol phosphatide, phosphatidylserine, phosphatidic acid and the like, and has the advantages of low cost, easy obtainment, high nutritive value and the like.
More preferably, the polyacrylic resin is polyacrylic resin IV and the film forming aid is soybean lecithin.
According to a further preferable technical scheme, the mass ratio of the polyacrylic resin IV to the soybean lecithin is 2 (2-3).
The inventors compared formulations of polyacrylic resin IV and soybean lecithin in mass ratios of 2:2 and 2:3 in experiments, with the abomasum passage rate of the formulation of polyacrylic resin IV and soybean lecithin in mass ratio of 2:3 being lowest. The mass ratio of the polyacrylic resin IV to the soybean lecithin is more preferably 2:3.
The preparation method of the core material (core-spun material) comprises the following steps:
1) Adding water and water-soluble starch into the active ingredient powder in the core material, rotationally extruding the mixed material through a screen, blasting balls in a shot blasting machine, drying, cooling to room temperature, and selecting particles with 20-30 meshes as the core material;
2) The mass of dry matters of the core material (core-coated material) and the coating liquid (the coating does not contain ethanol after being dried, the weight of the material is the ratio for removing the absolute ethanol) is 7-9: and 1-3, feeding.
3) And (3) performing bottom coating by adopting a coating machine, and sieving after coating material spraying to obtain the rumen bypass coating preparation.
In the step 1), 98 parts of active ingredient powder is taken, 1-4 parts of water-soluble starch is added, and 15-20 parts of water is added for uniform mixing; and (3) carrying out rotary extrusion on the mixed materials through a 0.5-2.0 mm screen, performing shot blasting in a shot blasting machine for 2-5 minutes, drying, cooling to room temperature, and selecting particles with 20-30 meshes as core materials.
More preferably, 8 is used in step 2): and 2, feeding the core coating material and the dry matter mass of the coating liquid.
Preferably, in the step 3), a fluidization coating machine is adopted for bottom spraying coating, and after coating material spraying is finished, the coating material is cooled to room temperature and screened so as to avoid adhesion. Sieving with 15-25 mesh sieve to obtain rumen bypass coating preparation.
The invention relates to an application of a coating preparation dissolved in rumen bypass abomasum in the production of ruminant feed additives.
The invention has the beneficial effects that:
1. the coating preparation provided by the invention adopts the polyacrylic resin IV and ethanol to be mixed to form the solution, and the plant phospholipid is fully mixed with the solution after being heated and melted, so that the preparation method is simple and controllable, does not need too high temperature, is beneficial to safe production, has short production period and is suitable for large-scale production.
2. The coating preparation product has good rumen bypass effect, and has high release rate in abomasum after rumen bypass, thereby being convenient for subsequent small intestine absorption.
3. The coating provided by the application has reasonable composition and proportion, and the obtained coating has good film forming property and is suitable for various coatings requiring rumen bypass medicines or additives.
Drawings
FIG. 1 shows the effect of in vitro rumen fluid anaerobic fermentation for 16 hours for the sample of example 2 of the present application;
FIG. 2 is an evaluation of the effect of 2 hours of artificial abomasum digestion of the sample of example 2 of the present application.
Detailed Description
The following examples are illustrative of the invention and are not intended to limit the scope of the invention.
Unless otherwise indicated, all technical means employed in the specification are those known in the art, and all raw materials used are commercially available.
The soybean phospholipids used in examples and comparative examples were obtained from medium grain oil and fat (lotus) limited and had a hard paste-like texture at ordinary temperature. Polyacrylic resin III was purchased from the pharmaceutical excipients of West An Jin Hunan Co.Ltd and was an irregular particle. Anhydrous ethanol was purchased from chinese medicine.
Unless otherwise specified, "parts" in examples and comparative examples are parts by mass.
The nutrients used in the examples and comparative examples were alfalfa flavonoids, but the scope of the present invention also includes other plant extracts having similar properties. Core material preparation is described in further detail herein, but the scope of protection of the present application is not limited thereto.
Comparative example 1
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for bonding and pelleting, and the specific operation is as follows: 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 20 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) And (3) taking 18 parts of soybean lecithin, heating to 70 ℃ to melt, pouring 6 parts of ethanol solution into the melted soybean lecithin, and obtaining the coating liquid after the materials are completely melted.
3) The mass of the core-spun material and the dry matter of the coating liquid is 8: and 2, feeding the weight of the coating core material and the coating liquid. And (3) carrying out bottom coating by adopting a fluidization coating machine, cooling to room temperature after coating material spraying is finished, and sieving to avoid adhesion. Sieving with 15-25 mesh sieve to obtain rumen bypass coating preparation.
Comparative example 2
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for agglomeration into pills, and the specific operation is that 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 20 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) And adding 9 parts of absolute ethyl alcohol into 6 parts of polyacrylic resin III, and obtaining the coating liquid after the materials are completely melted.
Step 3) was the same as in comparative example 1.
Comparative example 3
The core material was prepared as in comparative example 1.
2 parts of polyacrylic resin IV is taken, 3 parts of absolute ethyl alcohol is added, and the mixture is uniformly mixed to form a solution. Heating to about 70deg.C, and adding 0.5 parts of superfine talcum powder with particle size of more than 1000 before use.
Step 3) was the same as in comparative example 1.
Example 1
The present example provides a coated preparation, the preparation method is as follows:
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for agglomeration into pills, and the specific operation is that 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 16 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) 6 parts of polyacrylic resin IV is taken, 9 parts of absolute ethyl alcohol is added, and the mixture is uniformly mixed to form a solution. And (3) taking 6 parts of soybean lecithin, heating to 60-80 ℃ to melt, pouring an ethanol solution of polyacrylic resin IV into the melted soybean lecithin, and obtaining the coating liquid after the materials are completely melted.
3) The mass of the core-spun material and the dry matter of the coating liquid is 8: and 2, feeding the weight of the coating core material and the coating liquid. And (3) carrying out bottom coating by adopting a fluidization coating machine, cooling to room temperature after coating material spraying is finished, and sieving to avoid adhesion. Sieving with 15-25 mesh sieve to obtain rumen bypass coating preparation.
The rumen bypass coating preparation prepared by the preparation method has the advantages that various components are compatible and uniformly mixed, after a coating solution is prepared, the viscosity of materials is moderate when the materials are heated to 60-80 ℃, the film forming property is good, a coating finished product obtained by coating the solid medicine preparation by using the rumen bypass coating preparation is tightly attached to a medicine core, the coating is complete, light yellow oily luster is realized, the color is attractive, the coating is smooth and attractive, and various requirements of film coating of the solid medicine preparation can be better met.
Example 2
The present example provides a coated preparation, the preparation method is as follows:
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for agglomeration into pills, and the specific operation is that 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 18 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) 6 parts of polyacrylic resin IV is taken, 9 parts of absolute ethyl alcohol is added, and the mixture is uniformly mixed to form a solution. 9 parts of soybean lecithin is taken and heated to 70 ℃ to be melted, an ethanol solution of polyacrylic resin IV is poured into the melted soybean lecithin, and the coating liquid is obtained after the materials are completely melted.
Step 3) was the same as in example 1.
The rumen bypass coating preparation prepared by the preparation method has the advantages that various components are compatible and uniformly mixed, after a coating solution is prepared, the viscosity of materials is moderate when the materials are heated to 70 ℃, the film forming property is good, a coating finished product obtained by coating the solid medicine preparation by using the rumen bypass coating preparation is tightly attached to a medicine core, the coating is complete, light yellow oily luster is realized, the color is attractive, the coating is smooth and attractive, and various requirements of film coating of the solid medicine preparation can be better met.
Example 3
The present example provides a coated preparation, the preparation method is as follows:
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for agglomeration into pills, and the specific operation is that 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 20 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) 6 parts of polyacrylic resin IV is taken, 9 parts of absolute ethyl alcohol is added, and the mixture is uniformly mixed to form a solution. And (3) taking 18 parts of soybean lecithin, heating to 70 ℃ to melt, pouring an ethanol solution of polyacrylic resin IV into the melted soybean lecithin, and obtaining the coating liquid after the materials are completely melted.
Step 3) was the same as in example 1.
The rumen bypass coating preparation prepared by the preparation method has the advantages that various components are compatible and uniformly mixed, after a coating solution is prepared, the viscosity of materials is moderate when the materials are heated to 70 ℃, the film forming property is good, a coating finished product obtained by coating the solid medicine preparation by using the rumen bypass coating preparation is tightly attached to a medicine core, the coating is complete, light yellow oily luster is realized, the color is attractive, the coating is smooth and attractive, and various requirements of film coating of the solid medicine preparation can be better met.
Example 4
This example provides a coated formulation prepared by the steps of:
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for bonding and pelleting, and the specific operation is that 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 15-20 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) And adding 9 parts of absolute ethyl alcohol into 6 parts of polyacrylic resin III, and uniformly mixing to form a swelling material. Mixing uniformly to form a solution, taking 12 parts of soybean phospholipid, heating to 70 ℃ to melt, pouring an ethanol solution of polyacrylic resin III into the melted soybean phospholipid, and adding 0.5 part of superfine talcum powder with granularity more than 1000 meshes before use after the materials are completely melted to obtain a coating solution.
3) The mass of the core-spun material and the dry matter of the coating liquid (the coating is free of ethanol after drying, and the weight of the material is the proportion of the anhydrous ethanol removed) are according to 7:3-9:1, feeding. In this example, 8: and 2, feeding the weight of the coating core material and the coating liquid. And (3) carrying out bottom coating by adopting a fluidization coating machine, cooling to room temperature after coating material spraying is finished, and sieving to avoid adhesion. Sieving with 15-25 mesh sieve to obtain rumen bypass coating preparation.
Example 5
The present example provides a coated preparation, the preparation method is as follows:
1) Preparation of core-spun materials: comparative examples and examples use alfalfa flavonoids, a plant extract, as the active ingredient in the core-spun material. In order to facilitate coating, the water-soluble starch is used for agglomeration into pills, and the specific operation is that 98 parts of alfalfa flavone powder is taken, 2 parts of water-soluble starch is added, and 20 parts of water is added for uniform mixing. The mixed materials are subjected to rotary extrusion through a screen mesh with the diameter of 1.0mm, shot blasting is carried out for 3 minutes in a shot blasting machine, the materials are cooled to room temperature after being dried, and particles with the diameter of 20-30 meshes are selected to be reserved as core materials.
2) 6 parts of polyacrylic resin IV is taken, 9 parts of absolute ethyl alcohol is added, and the mixture is uniformly mixed to form a solution. And taking 12 parts of hydrogenated palm oil, heating to 110 ℃ to melt, pouring an ethanol solution of polyacrylic resin IV into the melted hydrogenated palm oil, and obtaining the coating liquid after the materials are completely melted.
Step 3) was the same as in example 1.
The above procedure gave rumen bypass coating formulations of comparative examples 1-3 and examples 1-5, which were subjected to application tests.
Application examples
Rumen bypass performance test was performed on the rumen bypass coating formulations prepared in comparative examples 1 to 3 and examples 1 to 5.
And (3) preparation of a reagent:
(1) trace element solution a:13.2g CaCl 2 •2H 2 O，10g MnCl 2 •4H 2 O，1g CoCl 2 •6H 2 O，8g FeCL 2 •6H 2 O, distilled water constant volume to 100mL
(2) Artificial saliva B:35g NaHCO 3 ，4g NH 4 HCO 3 Distilled water to a constant volume of 1000mL
(3) Macroelement solution C5.7 g Na 2 HPO 4 ，6.2g KH 2 PO 4 ，0.6g MgSO 4 •7H 2 O, distilled water is fixed to 1000 mL;
(4) 0.1% (w/v) of resazurin solution: weighing 100mg of resazurin, and fixing the volume to 100mL
(5) Reducing agent solution: weighing 625mg Na 2 S•9H 2 O, add 4 mL NaOH solution (4 g NaOH, distilled water to volume 100 mL) with concentration 1M, distilled water to volume 100mL.
Preparing a buffer solution: according to the experimental design requirement, the medicaments are added and prepared according to the following sequence and proportion: 400mL of distilled water, 0.1mL of trace element solution A and artificial saliva B:200mL of macroelement solution C, 200mL of resazurin solution, 0.1% (w/v): 1mL of reducing agent solution: 40mL; the preparation of the buffer solution is completed at night the day before the test starts, and the buffer solution is placed into a dark light-resistant container to be sealed and preserved by covering. The next day the test was prepared, reducing agent was added and the buffer was heated in a 39 ℃ water bath. Normally, after adding resazurin, the mixed solution appears red. Slowly and continuously introducing CO while heating in 39 ℃ water bath 2 The gas is kept for about 30min, the color of the mixed solution is changed from red to pink, and finally the mixed solution is colorless until the pH is approximately equal to 6.85.
Collecting rumen fluid: 3 pieces of Angas Niu Liuwei liquid with permanent rumen fistula are taken, passed through four layers of gauze and then brought back to a laboratory by a sealed thermos flask. The temperature is kept at 39 ℃ in the laboratory and carbon dioxide is introduced to maintain an anaerobic environment.
About 1g rumen protected sample was added to a 100mL fermentation flask and the exact weight was recorded, 25mL rumen fluid, 50 mL buffer solution, carbon dioxide was introduced, anaerobic fermentation at 39 ℃ for 16 hours, after which undigested sample in the fermentation flask was collected with a nylon bag (300 mesh pore size and weighed in advance) and dried to constant weight at 45 ℃ (avoiding high temperature film melting). Rumen passage rate was calculated as follows:
rumen pass (%) = (m) 3 -m 1 )÷m 2 ×100%
Wherein m is 1 Weight of nylon bag, m 2 For rumen bypass product weight, m 3 Is the weight of the nylon bag and the remainder after digestion.
Detection of overabomasal properties:
the sample is subjected to in vitro rumen fluid anaerobic fermentation for 16 hours, undigested parts are placed in a nylon bag, and the bag is sealed and placed in a culture flask. In vitro 2L of hydrochloric acid solution with pH=1.9 containing 1g/L pepsin (P-7000, sigma) was added to the flask, and the solution was preheated in advance. The flask was placed in an ANKOM Daisy II in vitro simulated fermentation incubator and spun at 39℃for 2h. Cleaning nylon bags with water and drying. The abomasum passing rate calculation principle is the same as the rumen passing rate calculation mode.
Description: when the abomasum passing rate is 0 (i.e., 100% of the sample disappears in the nylon bag), the small intestine passing performance test is no longer performed; when the passing rate at abomasum is greater than 0, the passing rate of the passing sample at small intestine is further examined.
And (3) preparation of a reagent:
179.07g of disodium hydrogen phosphate (Na) 2 HPO 4 ·12H 2 O, analytically pure), in distilled water to a volume of 1000mL.
78.01g of sodium dihydrogen phosphate (NaH) was taken as the solution B 2 PO 4 ·2H 2 O, analytically pure), in distilled water to a volume of 1000mL.
0.5mol/L phosphate buffer: 915mL of A solution and 85mL of B solution are taken and mixed, the pH is adjusted, when the pH is lower than 7.8, the A solution is properly increased, otherwise, the B solution is properly increased, and the pH is adjusted to 7.8.
To this buffer was added 50mg/L thymol and 3g/L trypsin (sigma-P-7545).
The nylon bag was removed and cleaned, and 2L of pre-warmed 0.5mol/L phosphate buffer containing 3g/L trypsin and 50mg/L thymol was added. And placing the culture flask in an ANKOMDAISY II in vitro simulated fermentation incubator, and culturing at 39deg.C for 24 hr. The nylon bag was taken out and washed to water clear, and baked in an oven at 45 ℃ to constant weight (48 h) to simulate a residue sample after digestion of the small intestine, and weighed. The small intestine passing rate calculation principle is the same as the rumen passing rate calculation mode.
The results of all examples are shown in Table 1.
TABLE 1
| Project | In vitro rumen passage% | 2 hours abomasum pass% | Small intestine pass rate% |
| Comparative example 1 | 10.2 | 0 | - |
| Comparative example 2 | 91.3 | 44.7 | 0 |
| Comparative example 3 | 98.6 | 6.7 | 0 |
| Example 1 | 98.6 | 3.5 | 0 |
| Example 2 | 97.2 | 0 | - |
| Example 3 | 78.5 | 0 | - |
| Example 4 | 87.5 | 25.8 | 0 |
| Example 5 | 83.6 | 0 | - |
As can be seen from table 1, the ratio of the phospholipid and the polyacrylic resin IV in the coating agent affects the passing rate of the rumen bypass coated product for 16h in vitro rumen bypass, wherein the passing rate of the rumen bypass coated product for 16h in vitro rumen bypass is 97.2% when 9 parts of vegetable phospholipid and 6 parts of polyacrylic resin IV are used, the passing rate of the rumen bypass coated product for 2h is 0 at the minimum, and the active ingredients of the core material are completely released (see fig. 1 and 2). As is clear from the comparison of example 5 with examples 1, 2 and 4, the use of hydrogenated palm oil as the coating material is not as effective as vegetable phospholipids dissolved in ethanol because it is not miscible with ethanol.
The main difference between example 2 and example 4 is represented by the use of polyacrylic resin IV for example 2 and polyacrylic resin iii for example 4. It can be seen that the use of polyacrylic resin III does not allow good dissolution of the coated product in the abomasum, and that 25.8% of the products after rumen bypass pass through the abomasum, which is not conducive to rapid release of the core-spun material after rumen bypass. Therefore, the present invention preferably uses polyacrylic resin IV as a coating material for rumen bypass and release in abomasum, and uses vegetable phospholipids to facilitate rapid release of the core-spun material (example 2 vs. comparative example 3).
Although the invention has been described by way of examples, it will be appreciated by those skilled in the art that modifications and variations may be made thereto without departing from the spirit and scope of the invention.
Claims (7)
1. A coating preparation for rumen dissolution of ruminant after rumen bypass comprises a core material and a coating, wherein the coating is prepared from coating liquid; the coating liquid is characterized in that: adding polyacrylic resin into absolute ethyl alcohol, uniformly mixing to form a solution, adding a film forming auxiliary agent, and obtaining the film forming auxiliary agent after the materials are completely melted; 6 parts by mass of polyacrylic resin and 6-24 parts by mass of film forming auxiliary agent, wherein the film forming auxiliary agent is vegetable phospholipid;
the film forming auxiliary agent is soybean lecithin, and the mass ratio of the polyacrylic resin IV to the soybean lecithin is 2 (2-3).
2. The coating preparation for rumen bypass and abomasal dissolution of ruminants according to claim 1, wherein the preparation method of the coating liquid comprises the following steps: and mixing the polyacrylic resin with absolute ethyl alcohol to form a polyacrylic resin solution, heating the plant phospholipid to 60-80 ℃, adding the polyacrylic resin solution after the materials are melted, and stirring and uniformly mixing to obtain the modified polyacrylic resin.
3. The coating preparation for rumen bypass and abomasal dissolution of ruminants according to claim 2, wherein the preparation method of the coating liquid comprises the following steps: and mixing 6 parts by mass of polyacrylic resin with 7-10 parts by mass of absolute ethyl alcohol to form polyacrylic resin solution, heating 6-9 parts by mass of vegetable phospholipids to 60-80 ℃, adding the polyacrylic resin solution after the materials are melted, and stirring and uniformly mixing to obtain the polyacrylic resin.
4. A ruminant rumen bypass and abomasal dissolution coating formulation according to any of claims 1-3, characterized in that the core material is prepared by a method comprising:
1) Adding water and water-soluble starch into the active ingredient powder in the core material, rotationally extruding the mixed material through a screen, blasting balls in a shot blasting machine, drying, cooling to room temperature, and selecting particles with 20-30 meshes as the core material;
2) The mass of dry matters of the core material and the coating liquid is 7-9: 1-3, feeding;
3) And (3) performing bottom coating by adopting a coating machine, and sieving after coating material spraying to obtain the rumen bypass coating preparation.
5. The ruminant rumen bypass and abomasum dissolved coating preparation according to claim 4, wherein in step 1), 98 parts of active ingredient powder is taken, 1-4 parts of water-soluble starch is added, and 15-20 parts of water is added for uniform mixing; and (3) carrying out rotary extrusion on the mixed materials through a screen mesh with the size of 0.5-20 mm, performing shot blasting in a shot blasting machine for 2-5 minutes, drying, cooling to room temperature, and selecting particles with the size of 20-30 meshes as core materials.
6. The coating preparation dissolved in rumen bypass and abomasum of ruminant animals according to claim 4, wherein in the step 3), a fluid coating machine is adopted for carrying out bottom coating, the coating preparation is cooled to room temperature after coating material spraying, and is screened by a 15-25-mesh screen, so as to obtain the rumen bypass coating preparation.
7. Use of the coating formulation of any one of claims 1 to 6 for rumen bypass, abomasal dissolution in the production of a ruminant feed additive.
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