CN117686696A - Quality control measurement method and blood analyzer - Google Patents

Abstract

The invention provides a quality control measuring method which is applied to a blood analyzer, wherein the blood analyzer comprises a conventional quality control measuring mode and a specific quality control measuring mode; the control module is used for controlling the blood analyzer to perform quality control measurement in a specific quality control measurement mode, and comprises: firstly, absorbing a first quality control product to be detected, and then reacting to obtain the first quality control product to be detected; in the reaction process of the first quality control product to be detected, absorbing a second quality control product to be detected, and reacting to obtain a second quality control product to be detected; after the reaction of the first and second quality control substances to be detected is finished, the first and second quality control substances to be detected are respectively subjected to quality control measurement through the first and second detection modules. In the method, quality control measurement of various quality control products to be measured can be simultaneously executed, so that quality control measurement time of the various quality control products to be measured is at least partially overlapped, the total required detection time of the quality control measurement of the various quality control products can be effectively reduced, the quality control measurement time can be effectively saved, and reagents and human resources are saved.

Description

Quality control measurement method and blood analyzer

Technical Field

The embodiment of the invention relates to the technical field of blood analysis, in particular to a quality control measurement method and a blood analyzer.

Background

Blood is currently used for analysis of human blood for the formation of constituents, such as the enumeration of red blood cells and the differential detection of white blood cells. Some specific proteins can be used as indicators for diagnosing diseases such as acute infection, cardiovascular diseases and cancers. Such as CRP (C-reactive protein) and SAA (serum amyloid a), there is a significant difference between viral and bacterial infection. Currently, all-in-one machines for detecting blood conventionally and specific proteins are available on the market. In order to ensure the running state of the instrument, repeated detection is required by using stable reference materials, namely quality control materials are used for quality control tests.

All-in-one machines for detecting blood routine and specific proteins are available in the market, but due to the fact that detection items are numerous, quality control of all detection items needs to be carried out by using various quality control products. The user needs to select different single modes to sequentially control the quality according to the type of the quality control product, and the method has the advantages of complex operation, large reagent consumption, long time consumption and occupation of human resources in departments.

Disclosure of Invention

Accordingly, the present invention is directed to a quality control measurement method and a blood analyzer, which are used for solving the problem of long time consumption of quality control measurement of various quality control products by the existing blood analyzer.

An aspect of the embodiment of the invention provides a quality control measurement method, which is applied to a blood analyzer, wherein the blood analyzer comprises a sample transfer module, a sample collection and distribution module, a reagent supply module, a first detection module, a second detection module and a control module, and the control module is respectively and electrically connected with the first detection module, the second detection module, the sample transfer module, the sample collection and distribution module and the reagent supply module;

the blood analyzer includes a conventional quality control measurement mode and a specific quality control measurement mode; the control module is used for controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, and comprises the following components:

firstly, a first quality control product to be detected is absorbed through the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the first quality control product to be detected in the first detecting module to obtain a first quality control product to be detected;

in the reaction process of the first to-be-detected quality control product, a second to-be-detected quality control product is absorbed through the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the second to-be-detected quality control product in the second detecting module to obtain a second to-be-detected quality control product;

And after the first to-be-detected quality control product and the second to-be-detected quality control product react, respectively carrying out quality control measurement on the first to-be-detected quality control product and the second to-be-detected quality control product through the first detection module and the second detection module.

Optionally, before the first to-be-detected quality control product is sucked, the first to-be-detected quality control product in the pipe rack is transferred to a sample sucking position of the blood analyzer through the sample transferring module,

and the sample transfer module transfers the second to-be-tested quality control product in the test tube rack to a sample suction position of the blood analyzer in the process that the first to-be-tested quality control product is reacted after the sample collection and distribution module sucks samples.

Optionally, after the first detection module and the second detection module respectively perform quality control measurement on the first quality control object to be measured and the second quality control object to be measured, the method further includes:

and after the first quality control object to be detected and the second quality control object to be detected are respectively measured, executing a cleaning process.

Optionally, when the first to-be-detected quality control product is a first specific protein control product, the second to-be-detected quality control product is a second specific protein control product, and the first to-be-detected quality control product and the second to-be-detected quality control product are different kinds of quality control products, the control of the blood analyzer to perform quality control measurement in the specific quality control measurement mode further includes:

Firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control;

in the reaction process of the first specific protein control, the sample collecting and distributing module is used for sucking the second specific protein control, and the reagent conveyed by the reagent supplying module reacts with the second specific protein control in the second detecting module to obtain a second specific protein control;

and after the reaction of the first specific protein control and the second specific protein control is finished, respectively performing mass control measurement on the first specific protein control and the second specific protein control through the first detection module and the second detection module.

Optionally, when the first to-be-detected quality control product is a first specific protein control product and the second to-be-detected quality control product is a blood routine quality control product, controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, further including:

firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control;

In the reaction process of the first specific protein control, the blood routine quality control is sucked through the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the blood routine quality control in the second detecting module to obtain the blood routine quality control;

and after the reaction of the first specific protein control and the blood routine quality control is finished, respectively performing quality control measurement on the first specific protein control and the blood routine quality control through the first detection module and the second detection module.

Optionally, when the first to-be-detected quality control is a first specific protein control, the second to-be-detected quality control is a second specific protein control,

the control module is further configured to: in the same measuring process, a third detection module is controlled to carry out quality control measurement on a third quality control object to be measured, wherein the third quality control object to be measured is a blood routine quality control object;

controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, further comprising:

firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control;

In the reaction process of the first specific protein control, the sample collecting and distributing module is used for sucking the second specific protein control, and the reagent conveyed by the reagent supplying module reacts with the second specific protein control in the second detecting module to obtain a second specific protein control;

in the process that the first specific protein control and the second specific protein control are respectively reacted, the sample collection and distribution module absorbs the blood routine quality control, and the reagent conveyed by the reagent supply module reacts with the blood routine quality control in the third detection module;

and finally, respectively carrying out quality control measurement on the first specific protein control object, the second specific protein control object and the blood routine quality control object through the first detection module, the second detection module and the third detection module.

Optionally, the control module is further configured to: performing quality control measurement on a third quality control object to be measured and a fourth quality control object to be measured in the conventional quality control measurement mode, wherein the third quality control object to be measured and the fourth quality control object to be measured are the same type of quality control object and have different concentrations,

The quality control measurement method further comprises the following steps:

firstly, sucking the third to-be-detected quality control product through the sample collecting and distributing module, reacting the reagent conveyed by the reagent supplying module with the third to-be-detected quality control product to obtain a third to-be-detected quality control product, and performing quality control measurement on the third to-be-detected quality control product;

and after the third quality control object to be measured is subjected to quality control measurement, the fourth quality control object to be measured is sucked through the sample collecting and distributing module, the reagent conveyed by the reagent supplying module reacts with the fourth quality control object to be measured, so that the fourth quality control object to be measured is obtained, and the fourth quality control object to be measured is subjected to quality control measurement.

Optionally, when the first to-be-detected quality control product and the second to-be-detected quality control product are different quality control products, the duration of performing quality control measurement on the first to-be-detected quality control product and the second to-be-detected quality control product in the specific quality control measurement mode is T1; when the first to-be-detected quality control product and the second to-be-detected quality control product are different types of quality control products and have different concentrations, the duration of quality control measurement on the first to-be-detected quality control product and the second to-be-detected quality control product in a conventional quality control measurement mode is T2, and T1 is smaller than T2.

Optionally, the consumption of the reagent required for performing quality control measurement on the first to-be-measured quality control product and the second to-be-measured quality control product in the specific quality control measurement mode is a first consumption of the reagent, and the consumption of the reagent required for performing quality control measurement on the first to-be-measured quality control product and the second to-be-measured quality control product in the conventional quality control measurement mode is a second consumption of the reagent, wherein the first consumption of the reagent is smaller than the second consumption of the reagent.

An aspect of an embodiment of the present invention further provides a blood analyzer, including:

the device comprises a sample transfer module, a sample collection and distribution module, a reagent supply module, a first detection module, a second detection module and a control module, wherein the control module is respectively and electrically connected with the first detection module, the second detection module, the sample transfer module, the sample collection and distribution module and the reagent supply module;

the hematology analyzer includes a conventional quality control measurement mode and a specific quality control measurement mode,

in the specific quality control measurement mode:

the sample collection and distribution module is used for sucking the first quality control product to be tested, the reagent supply module is used for conveying a reagent, and the first detection module is used for: receiving the reagent and the first quality control product to be detected, which are conveyed by the reagent supply module, so that the reagent and the first quality control product to be detected react to obtain a first quality control product to be detected;

In the reaction process of the first to-be-detected object, the sample collecting and distributing module is also used for sucking the second to-be-detected object, and the second detecting module is used for receiving the reagent conveyed by the reagent supplying module and the second to-be-detected object so as to enable the reagent to react with the second to-be-detected object to obtain a second to-be-detected object;

after the reaction of the first quality control object to be detected and the second quality control object to be detected is completed, the first detection module is further used for performing quality control measurement on the first quality control object to be detected, and the second detection module is further used for performing quality control measurement on the second quality control object to be detected.

The quality control measuring method and the blood analyzer provided by the embodiment of the invention comprise a sample transferring module, a sample collecting and distributing module, a reagent supplying module, a first detecting module, a second detecting module and a control module, wherein the control module is respectively and electrically connected with the first detecting module, the second detecting module, the sample transferring module, the sample collecting and distributing module and the reagent supplying module; the blood analyzer comprises a conventional quality control measuring mode and a specific quality control measuring mode; the control module is used for controlling the blood analyzer to perform quality control measurement in a specific quality control measurement mode, and comprises: firstly, a first quality control product to be detected is absorbed through a sample collecting and distributing module, and a reagent conveyed through a reagent supplying module reacts with the first quality control product to be detected in a first detecting module to obtain a first quality control product to be detected; in the reaction process of the first to-be-detected quality control product, a second to-be-detected quality control product is absorbed by a sample collecting and distributing module, and a reagent conveyed by a reagent supplying module reacts with the second to-be-detected quality control product in a second detecting module to obtain a second to-be-detected quality control product; after the reaction of the first to-be-detected quality control product and the second to-be-detected quality control product is completed, the first to-be-detected quality control product and the second to-be-detected quality control product are subjected to quality control measurement through the first detection module and the second detection module respectively. Compared with the prior art, the following scheme for quality control detection quantity aiming at different types of quality control products: finishing the quality control measurement of one type, then carrying out the quality control measurement of the next type, and the like until all types of quality control measurement and cleaning; in the embodiment of the application, the quality control measurement of various quality control products can be simultaneously executed, so that the quality control measurement time of the quality control products to be measured of various types is at least partially overlapped, the total required detection time of the quality control measurement of the quality control products of various types can be effectively reduced, the quality control measurement time can be effectively saved, and the reagent and the human resources are saved.

The invention will now be described in more detail with reference to the drawings and specific examples, which are not intended to limit the invention thereto.

Drawings

FIG. 1 schematically shows a schematic structure of a blood analyzer according to an embodiment of the present invention;

fig. 2 schematically shows a schematic diagram of a test tube rack in an embodiment of the present invention;

fig. 3 schematically shows a schematic view of the placement of quality control substances in a test tube rack according to an embodiment of the invention;

FIG. 4 schematically illustrates a schematic flow chart of a quality control measurement method according to an embodiment of the present invention;

FIG. 5 schematically illustrates a sequence of quality control measurements performed by a plurality of quality control products according to a third embodiment of the invention;

fig. 6 schematically shows a timing diagram for implementing a quality control measurement method according to the present invention.

Detailed Description

The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

It should be noted that the descriptions of "first," "second," etc. in the embodiments of the present invention are for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.

In the description of the present invention, it should be understood that the numerical references before the steps do not identify the order in which the steps are performed, but are merely used to facilitate description of the present invention and to distinguish between each step, and thus should not be construed as limiting the present invention.

Referring to fig. 1, an embodiment of the present invention provides a blood analyzer, including: comprises a detection module 10, a sample transfer module 101, a sample collection and distribution module 103, a reagent supply module and a control module 102; the detection module 10 includes a blood routine detection module 106 and at least two specific protein detection modules. Wherein, the blood analyzer comprises, but is not limited to, a blood routine and specific protein combined detection integrated machine, a blood routine+specific protein+blood sedimentation combined detection integrated machine, a blood routine+specific protein+body fluid combined detection integrated machine and the like. Taking a blood routine and specific protein combined detection integrated machine as an example, at least two specific protein detection modules comprise: a CRP measurement module 104 and a SAA detection module 105.

In the present application, the blood routine detection module 106 is configured to react and detect the dispensed sample to be detected to obtain at least one blood routine parameter; the at least two specific protein detection modules are used for carrying out corresponding reaction and detection on the allocated samples to be detected so as to respectively obtain at least one corresponding specific protein parameter; the sample collection and distribution module is used for collecting a sample to be detected and distributing the sample to be detected to the blood routine detection module 106 and the at least two specific protein detection modules, wherein the sample to be detected comprises a quality control product to be detected; the sample transfer module is used for conveying the test tube rack 20 in which the test tubes are placed; the reagent supply module is configured to supply reagents to the blood routine detection module 106 and the at least two specific protein detection modules; the control module is electrically connected to the blood routine detection module 106, the at least two specific protein detection modules, the sample collection and distribution module 103, the sample transfer module, and the reagent supply module, respectively.

Wherein please combine fig. 2-3, be provided with a plurality of test tube positions on the test-tube rack 20, correspond to on every test tube position and have test tube position number 201, as shown in the figure, including test tube position number 1, test tube position number 2, test tube position number 3, test tube position number 4, test tube position number 5, test tube position number 6, test tube position number 7, test tube position number 8, test tube position number 9, test tube position number 10 on a test-tube rack 20. Each test tube position is used for placing one test tube, and the to-be-tested objects carried in the test tube can comprise, but are not limited to, to-be-tested sample liquid used for carrying out conventional measurement flow, CRP quality control 301 used for carrying out CRP quality control measurement, SAA quality control 302 used for carrying out SAA quality control measurement, blood conventional quality control 303 used for carrying out blood conventional quality control measurement and the like. The number of test tubes placed on each test tube rack 20 and the types of the objects to be tested carried in the test tubes can be set according to actual requirements, and are not limited herein. The number of test tube positions set on each test tube rack 20 can be set according to practical requirements, and is not limited herein.

In the present application, the blood analyzer includes a conventional quality control measurement mode and a specific quality control measurement mode; the control module is used for controlling the blood analyzer to conduct quality control measurement in the specific quality control measurement mode. Specifically, the control module 102 is configured to perform the following operations of the quality control measurement method in the following embodiments. It will be appreciated that the flow charts in the method embodiments are not intended to limit the order in which the steps are performed. The following description will be made with the control module 102 as an execution body, specifically as follows:

referring to fig. 4, the controlling the blood analyzer to perform the quality control measurement in the specific quality control measurement mode may include steps S400 to S404, wherein:

in step S400, a first quality control product to be detected is first sucked by the sample collecting and distributing module 103, and the reagent conveyed by the reagent supplying module reacts with the first quality control product to be detected in the first detecting module to obtain a first quality control product to be detected.

In this application, control module acquire test tube position information of test-tube rack 20 with wait to detect quality control article information on the test-tube rack 20, wherein, test tube position information includes occupation information and idle information, wait to detect quality control article information includes: the type of the quality control product to be detected and the concentration parameter of the quality control product to be detected. The quality control concentration parameter comprises a first concentration, a second concentration and a third concentration. The first concentration corresponds to a low concentration, the second concentration corresponds to a medium concentration, and the third concentration corresponds to a high concentration. And determining the current quality control measurement mode as a specific quality control measurement mode according to the test tube position information and the quality control information to be detected.

In step S402, during the reaction process of the first to-be-detected quality control product, a second to-be-detected quality control product is sucked by the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the second to-be-detected quality control product in the second detecting module to obtain a second to-be-detected quality control product.

In step S404, after the reaction of the first to-be-detected quality control product and the second to-be-detected quality control product is completed, the first to-be-detected quality control product and the second to-be-detected quality control product are respectively measured by the first detection module and the second detection module.

Compared with the prior art, the following scheme for quality control detection quantity aiming at different types of quality control products: after finishing quality control measurement of one type and cleaning, performing quality control measurement of the next type and cleaning, and the like until quality control measurement of all types and cleaning are performed; in the embodiment of the application, the quality control measurement mode is determined by the test tube position information of the test tube rack 20 and the quality control information to be detected, when the quality control measurement mode is the specific quality control measurement mode, in the process of sucking the first quality control to be detected for reaction, the second quality control to be detected is not required to be sucked until the first quality control to be detected is completely reacted, and the second quality control to be detected can be sucked as long as the component of the sample collection and distribution module is in an idle state. In the application, before the first to-be-detected quality control product is sucked, the first to-be-detected quality control product in a pipe rack is transferred to a sample sucking position of the blood analyzer through the sample transfer module; and the sample transfer module transfers the second to-be-tested quality control product in the test tube rack to a sample suction position of the blood analyzer in the process that the first to-be-tested quality control product is reacted after the sample collection and distribution module sucks samples. When the sample collection and distribution module comprises at least two sampling needle assemblies, if the two sampling needle assemblies are in an idle state, the two sampling needle assemblies can be used for simultaneously absorbing the corresponding first to-be-detected quality control product and the corresponding second to-be-detected quality control product; when only one sampling needle component is in an idle state, a first to-be-detected quality control product can be firstly sucked through the idle sampling needle component, and at the moment, when the sampling needle component is in the idle state, a second to-be-detected quality control product can be sucked; for example, in the process that the sampling needle which absorbs the first to-be-detected quality control product moves towards the first detection module, another sampling needle component is idle, and the second to-be-detected quality control product can be absorbed through the other idle sampling needle component.

According to the scheme, quality control measurement of various quality control products to be measured can be simultaneously performed, so that quality control measurement time of the various quality control products to be measured is at least partially overlapped, the total required detection time of the quality control measurement of the various quality control products to be measured can be effectively reduced, the quality control measurement time can be effectively saved, and reagents and human resources are saved.

In an exemplary embodiment, the quality control measurement method further includes: quality control information of each test tube position in the test tube rack 20 is preset, wherein the preset quality control information comprises quality control type and quality control concentration parameters. Illustratively, a user places a corresponding quality control product test tube according to quality control product information preset in the test tube position, so as to perform quality control measurement by a blood supply analyzer. In this embodiment, the blood analyzer only needs to identify whether the corresponding test tube exists or not, and can identify the type of the quality control product to be detected and the concentration parameter of the quality control product, so that the detection efficiency is high.

In a first embodiment, the blood analyzer further comprises a sample transfer module 101, a sample collection and distribution module 103, a blood routine detection module 106, at least two specific protein detection modules, and a reagent supply module, wherein the control module 102 is electrically connected to the blood routine detection module 106, the at least two specific protein detection modules, the sample collection and distribution module 103, the sample transfer module 101, and the reagent supply module, respectively; wherein the at least two specific protein detection modules comprise a CRP detection module 104 and a SAA detection module 105.

When the first to-be-detected quality control product is a first specific protein control product, the second to-be-detected quality control product is a second specific protein control product, and the first to-be-detected quality control product and the second to-be-detected quality control product are different types of quality control products, wherein the first specific protein control product is a CRP quality control product, and the second specific protein control product is an SAA quality control product; controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, further comprising:

firstly, sucking the first specific protein control through the sample collecting and distributing module 103, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain a first specific protein control; in the reaction process of the first specific protein control, the sample collecting and distributing module 103 is used for sucking the second specific protein control, and the reagent conveyed by the reagent supplying module reacts with the second specific protein control in the second detecting module to obtain a second specific protein control; and after the reaction of the first specific protein control and the second specific protein control is finished, respectively performing mass control measurement on the first specific protein control and the second specific protein control through the first detection module and the second detection module.

In this application, when it is determined that a hematology analyzer requires a quality control measurement of two specific proteins, a specific quality control measurement mode is determined to be employed. In the first embodiment, the first specific protein control is an SAA quality control, the second specific protein control is a CRP quality control, and since the reaction time of the SAA quality control and the CRP quality control is relatively slow, which quality control is first to sample, the previous reaction has little influence on the total detection time required by executing the specific quality control measurement mode at this time, and the measurement time can be overlapped, so as to achieve the effect of shortening the total measurement time; therefore, the sequential sample suction sequence of the two quality control products to be detected is not limited. In other embodiments, specific protein controls may also include, but are not limited to PCT (procalcitonin), hbA1c (glycosylated hemoglobin).

In a second embodiment, when the first to-be-detected quality control product is a first specific protein control product, the second to-be-detected quality control product is a blood routine quality control product, the first detection module is a first specific protein detection module, and the second detection module is a blood routine detection module 106, the control unit is configured to control the blood analyzer to perform quality control measurement in the specific quality control measurement mode, and the control unit further includes:

Firstly, sucking the first specific protein control through the sample collecting and distributing module 103, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain a first specific protein control; in the reaction process of the first specific protein control, the blood routine quality control is sucked through the sample collecting and distributing module 103, and the reagent conveyed through the reagent supplying module reacts with the blood routine quality control in the second detecting module to obtain the blood routine quality control; and after the reaction of the first specific protein control and the blood routine quality control is finished, respectively performing quality control measurement on the first specific protein control and the blood routine quality control through the first detection module and the second detection module. In this application, when it is determined that the blood analyzer requires quality control measurements for a first specific protein control and a blood routine quality control, a specific quality control measurement mode is determined to be employed. In the second embodiment, since the time for blood routine quality control measurement is shorter than that for the first specific protein control measurement, the quality control measurement mode of sampling the first specific protein control and then sucking the blood routine quality control can superimpose the measurement time of the two kinds of quality control to be measured, thereby achieving the effect of shortening the total measurement time. Among other things, blood routine measurements include CBC mode (for whole blood count) measurements and DIFF mode (for classifying white blood cells) measurements. Illustratively, the mode combination for performing the quality control measurement according to the second embodiment includes: CBC+CRP/SAA; diff+crp/SAA; CBC+DIFF+CRP/SAA.

In a third embodiment, when the first to-be-detected quality control product is a first specific protein control product, the second to-be-detected product is a second specific protein control product, the first detection module is a CRP detection module 104, and the second detection module is a SAA detection module 105; the control module is further configured to: in the same measuring process, a third detection module is controlled to carry out quality control measurement on a third quality control object to be measured, wherein the third quality control object to be measured is a blood routine quality control object; the third detection module is a blood routine detection module;

controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, further comprising:

firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control; in the reaction process of the first specific protein control, the sample collecting and distributing module is used for sucking the second specific protein control, and the reagent conveyed by the reagent supplying module reacts with the second specific protein control in the second detecting module to obtain a second specific protein control; in the process that the first specific protein control and the second specific protein control are respectively reacted, the sample collection and distribution module absorbs the blood routine quality control, and the reagent conveyed by the reagent supply module reacts with the blood routine quality control in the third detection module; and finally, respectively carrying out quality control measurement on the first specific protein control object, the second specific protein control object and the blood routine quality control object through the first detection module, the second detection module and the third detection module. In the third embodiment, since the time of blood routine quality control measurement is shorter than the time of the first specific protein control measurement and the second specific protein control measurement, the measurement time of three kinds of quality control substances to be measured can be overlapped by sampling the quality control measurement mode of firstly sucking the first specific protein control substance, then sucking the second specific protein control substance and then sucking the blood routine quality control substance, thereby achieving the effect of shortening the total measurement time. Illustratively, the mode combination for performing the quality control measurement according to the third embodiment includes: cbc+diff+crp+saa. For example, referring to fig. 5, the following operations are performed according to the step flow illustrated by the arrows from left to right and from top to bottom in fig. 5: when the quality control variety to be tested comprises a CRP quality control product 301, an SAA quality control product 302 and a blood routine quality control product 303, firstly, transferring the CRP quality control product 301 in the test tube rack 20 to a sample suction position of the blood analyzer through the sample transfer mechanism; sucking a first object to be detected in the CRP quality control product 301 through the sample collection and distribution module 103 and reacting; secondly, in the process of reacting the CRP quality control product, the SAA quality control product 302 in the test tube rack 20 is transferred to a sample suction position of the blood analyzer through the sample transfer mechanism; sucking a second object to be detected in the SAA quality control product 302 through the sample collection and distribution module 103 and reacting; finally, in the process of reacting the SAA quality control product, transferring the blood routine quality control product 303 in the test tube rack 20 to a sample sucking position of the blood analyzer through the sample transfer mechanism; and the sample collection and distribution module 103 is used for sucking a third to-be-detected object in the blood routine quality control product 303, and the reagent conveyed by the reagent supply module and the third to-be-detected object react and are detected by the blood routine detection module 106. In the above embodiment, when two or more types of the quality control substances to be detected are detected, the time for starting the sample suction of the specific protein control substances is earlier than the time for starting the sample suction of the blood conventional quality control substances as long as at least one specific protein control substance and the blood conventional quality control substances 303 are present. Parameters obtained by blood routine quality control detection are not used for a specific protein detection module, namely, in the process of quality control measurement, the specific protein detection does not need to correct the measurement result of the related specific protein by using parameters obtained by blood routine detection, such as HCT parameters (hematocrit).

In an exemplary embodiment, after the first detection module and the second detection module perform quality control measurement on the first quality control object to be measured and the second quality control object to be measured respectively, the method further includes:

and after the first quality control object to be measured and the second quality control object to be measured are measured respectively, a cleaning flow is executed to clean the blood analyzer.

In the present application, the control module 102 receives an application quality control command; after the sample information of the sample to be tested of each test tube position of the test tube rack 20 is detected, if the sample information of the sample to be tested includes quality control information of the quality control to be tested, then measurement information of the quality control is generated according to the application quality control command, and the measurement information includes the quality control information to be tested, the test tube position information and the target quality control measurement mode. The control module 102 generates a control measurement instruction according to the measurement information of the quality control product, so that the blood analyzer can respond to the control measurement instruction to execute the corresponding control measurement operation.

In a fourth embodiment, the control module is further configured to: performing quality control measurement on a third quality control object to be measured and a fourth quality control object to be measured in the conventional quality control measurement mode, wherein the third quality control object to be measured and the fourth quality control object to be measured are the same type of quality control object and have different concentrations,

The quality control measurement method further comprises the following steps:

firstly, sucking the third to-be-detected quality control product through the sample collecting and distributing module, reacting the reagent conveyed by the reagent supplying module with the third to-be-detected quality control product to obtain a third to-be-detected quality control product, and performing quality control measurement on the third to-be-detected quality control product; and after the third quality control object to be measured is subjected to quality control measurement, the fourth quality control object to be measured is sucked through the sample collecting and distributing module, the reagent conveyed by the reagent supplying module reacts with the fourth quality control object to be measured, so that the fourth quality control object to be measured is obtained, and the fourth quality control object to be measured is subjected to quality control measurement.

An exemplary conventional quality control measurement mode is described, when the quality control variety to be measured includes a conventional quality control material 303, and the conventional quality control material 303 includes three conventional quality control materials 303 with different concentration parameters, for example, the third quality control material to be measured is one of a high-concentration conventional quality control material, a medium-concentration conventional quality control material and a low-concentration conventional quality control material, and the fourth quality control material to be measured is another of the high-concentration conventional quality control material, the medium-concentration conventional quality control material and the low-concentration conventional quality control material; and carrying out quality control measurement on the quality control product to be detected in sequence according to the sequence of the test tube positions of the quality control product to be detected. In the application, quality control measurement is sequentially performed on quality control substances to be detected according to the sample injection direction of the test tube rack 20, the sample transfer module 101 is not required to be driven reversely, and the quality control measurement efficiency of the blood analyzer is effectively improved.

In an exemplary embodiment, when the first to-be-measured quality control product and the second to-be-measured quality control product are different types of quality control products, a duration of performing quality control measurement on the first to-be-measured quality control product and the second to-be-measured quality control product in the specific quality control measurement mode is T1; when the first to-be-detected quality control product and the second to-be-detected quality control product are different types of quality control products and have different concentrations, the duration of quality control measurement on the first to-be-detected quality control product and the second to-be-detected quality control product in a conventional quality control measurement mode is T2, and T1 is smaller than T2. In the application, according to the consideration of the reaction time length of different types of quality control products to be detected and the total time length of quality control measurement of the same type of quality control products to be detected, a specific quality control measurement mode is adopted for the different types of quality control products, a conventional quality control measurement mode is adopted for the same type of quality control products with different concentrations, the selection of the quality control measurement mode is combined with the types of the quality control products to be detected, the quality control measurement efficiency under different modes is effectively improved, and the quality control measurement time is saved. Referring to fig. 6, taking crp+saa+blood conventional quality control measurement as an example, the conventional quality control measurement mode is: firstly, sucking a sample CRP quality control product, and performing reaction, quality control detection and cleaning; after CRP quality control detection and cleaning are finished, the sample SAA quality control product is absorbed again, and reaction, quality control detection and cleaning are carried out; after SAA quality control, detection and cleaning are finished, finally, sucking a conventional quality control product of sample blood, and performing reaction, quality control, detection and cleaning, wherein the required time length can be understood as T2; the scheme of the quality control measurement method in the application is as follows: the sample CRP quality control product is firstly absorbed, the sample SAA quality control product can be absorbed after the CRP quality control product is injected into the detection module, the sample blood routine quality control product can be absorbed after the SAA quality control product is injected into the detection module, and the reaction and detection time of the CRP quality control product, the SAA quality control product and the blood routine quality control product are overlapped, so that the required duration can be understood as the T1.

In an exemplary embodiment, the reagent consumption required for performing quality control measurement on the first to-be-measured quality control product and the second to-be-measured quality control product in the specific quality control measurement mode is a first reagent consumption, and the reagent consumption required for performing quality control measurement on the first to-be-measured quality control product and the second to-be-measured quality control product in the conventional quality control measurement mode is a second reagent consumption, and the first reagent consumption is smaller than the second reagent consumption. Illustratively, CRP+SAA+blood routine performed in a specific quality control measurement mode is sequentially sampled, then subsequent reactions are performed and the total reagent consumption of the next single mode measurement is performed after the single mode measurement is sequentially completed in a reagent consumption < blood routine mode, CRP mode and SAA mode in the whole quality control measurement process.

The application has at least the following beneficial effects:

(1) The required time of quality control measurement of various quality control is reduced, the total time length of at least two quality control measurement is far less than the required time length of at least two quality control independent quality control measurement, the quality control measurement time is saved, the reagent is saved, and the human resources are liberated;

(2) According to the quality control measurement method, the to-be-measured objects in a plurality of quality control products can be sucked for simultaneous measurement according to the quantity and the types of the quality control products, so that the detection time can be greatly shortened, and the consumption of reagents is reduced.

The foregoing embodiment numbers of the present invention are merely for the purpose of description, and do not represent the advantages or disadvantages of the embodiments.

The foregoing description is only of the preferred embodiments of the present invention, and is not intended to limit the scope of the invention, but rather is intended to cover any equivalents of the structures or equivalent processes disclosed herein or in the alternative, which may be employed directly or indirectly in other related arts.

Claims (10)

1. The quality control measurement method is characterized by being applied to a blood analyzer, wherein the blood analyzer comprises a sample transfer module, a sample collection and distribution module, a reagent supply module, a first detection module, a second detection module and a control module, and the control module is respectively and electrically connected with the first detection module, the second detection module, the sample transfer module, the sample collection and distribution module and the reagent supply module;

the blood analyzer includes a conventional quality control measurement mode and a specific quality control measurement mode; the control module is used for controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, and comprises the following components:

firstly, a first quality control product to be detected is absorbed through the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the first quality control product to be detected in the first detecting module to obtain a first quality control product to be detected;

In the reaction process of the first to-be-detected quality control product, a second to-be-detected quality control product is absorbed through the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the second to-be-detected quality control product in the second detecting module to obtain a second to-be-detected quality control product;

and after the first to-be-detected quality control product and the second to-be-detected quality control product react, respectively carrying out quality control measurement on the first to-be-detected quality control product and the second to-be-detected quality control product through the first detection module and the second detection module.

2. The quality control measurement method according to claim 1, wherein,

before the first quality control product to be detected is sucked, the first quality control product to be detected in the pipe rack is transferred to a sample sucking position of the blood analyzer through the sample transferring module,

and the sample transfer module transfers the second to-be-tested quality control product in the test tube rack to a sample suction position of the blood analyzer in the process that the first to-be-tested quality control product is reacted after the sample collection and distribution module sucks samples.

3. The quality control measurement method according to claim 2, wherein after the first and second detection modules perform quality control measurement on the first and second quality control objects, respectively, the method further comprises:

And after the first quality control object to be detected and the second quality control object to be detected are respectively measured, executing a cleaning process.

4. The quality control measurement method according to claim 3, wherein,

when the first to-be-detected quality control product is a first specific protein control product, the second to-be-detected quality control product is a second specific protein control product, and the first to-be-detected quality control product and the second to-be-detected quality control product are different types of quality control products, the control of the blood analyzer to perform quality control measurement in the specific quality control measurement mode further comprises:

firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control;

in the reaction process of the first specific protein control, the sample collecting and distributing module is used for sucking the second specific protein control, and the reagent conveyed by the reagent supplying module reacts with the second specific protein control in the second detecting module to obtain a second specific protein control;

and after the reaction of the first specific protein control and the second specific protein control is finished, respectively performing mass control measurement on the first specific protein control and the second specific protein control through the first detection module and the second detection module.

5. The quality control measurement method according to claim 3, wherein when the first quality control to be measured is a first specific protein control and the second quality control to be measured is a blood routine quality control, the quality control measurement by the blood analyzer is controlled in the specific quality control measurement mode, further comprising:

firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control;

in the reaction process of the first specific protein control, the blood routine quality control is sucked through the sample collecting and distributing module, and the reagent conveyed by the reagent supplying module reacts with the blood routine quality control in the second detecting module to obtain the blood routine quality control;

and after the reaction of the first specific protein control and the blood routine quality control is finished, respectively performing quality control measurement on the first specific protein control and the blood routine quality control through the first detection module and the second detection module.

6. The method of claim 3, wherein when the first test substance is a first specific protein control and the second test substance is a second specific protein control,

The control module is further configured to: in the same measuring process, a third detection module is controlled to carry out quality control measurement on a third quality control object to be measured, wherein the third quality control object to be measured is a blood routine quality control object;

controlling the blood analyzer to perform quality control measurement in the specific quality control measurement mode, further comprising:

firstly, sucking the first specific protein control through the sample collecting and distributing module, and reacting the reagent conveyed by the reagent supplying module with the first specific protein control in the first detecting module to obtain the first specific protein control;

in the reaction process of the first specific protein control, the sample collecting and distributing module is used for sucking the second specific protein control, and the reagent conveyed by the reagent supplying module reacts with the second specific protein control in the second detecting module to obtain a second specific protein control;

in the process that the first specific protein control and the second specific protein control are respectively reacted, the sample collection and distribution module absorbs the blood routine quality control, and the reagent conveyed by the reagent supply module reacts with the blood routine quality control in the third detection module;

And finally, respectively carrying out quality control measurement on the first specific protein control object, the second specific protein control object and the blood routine quality control object through the first detection module, the second detection module and the third detection module.

7. The quality control measurement method of claim 3, wherein the control module is further configured to: performing quality control measurement on a third quality control object to be measured and a fourth quality control object to be measured in the conventional quality control measurement mode, wherein the third quality control object to be measured and the fourth quality control object to be measured are the same type of quality control object and have different concentrations,

the quality control measurement method further comprises the following steps:

firstly, sucking the third to-be-detected quality control product through the sample collecting and distributing module, reacting the reagent conveyed by the reagent supplying module with the third to-be-detected quality control product to obtain a third to-be-detected quality control product, and performing quality control measurement on the third to-be-detected quality control product;

and after the third quality control object to be measured is subjected to quality control measurement, the fourth quality control object to be measured is sucked through the sample collecting and distributing module, the reagent conveyed by the reagent supplying module reacts with the fourth quality control object to be measured, so that the fourth quality control object to be measured is obtained, and the fourth quality control object to be measured is subjected to quality control measurement.

8. The quality control measurement method according to any one of claims 3 to 7, wherein when the first quality control to be measured and the second quality control to be measured are different types of quality control, a duration of performing quality control measurement on the first quality control to be measured and the second quality control to be measured in the specific quality control measurement mode is T1; when the first to-be-detected quality control product and the second to-be-detected quality control product are different types of quality control products and have different concentrations, the duration of quality control measurement on the first to-be-detected quality control product and the second to-be-detected quality control product in a conventional quality control measurement mode is T2, and T1 is smaller than T2.

9. The quality control measurement method according to claim 8, wherein the consumption of the reagent required for quality control measurement of the first quality control to be measured and the second quality control to be measured in the specific quality control measurement mode is a first consumption of the reagent, and the consumption of the reagent required for quality control measurement of the first quality control to be measured and the second quality control to be measured in the regular quality control measurement mode is a second consumption of the reagent, the first consumption of the reagent being smaller than the second consumption of the reagent.

10. A blood analyzer, comprising: the device comprises a sample transfer module, a sample collection and distribution module, a reagent supply module, a first detection module, a second detection module and a control module, wherein the control module is respectively and electrically connected with the first detection module, the second detection module, the sample transfer module, the sample collection and distribution module and the reagent supply module;

The hematology analyzer includes a conventional quality control measurement mode and a specific quality control measurement mode,

in the specific quality control measurement mode:

the sample collection and distribution module is used for sucking the first quality control product to be tested, the reagent supply module is used for conveying a reagent, and the first detection module is used for: receiving the reagent and the first quality control product to be detected, which are conveyed by the reagent supply module, so that the reagent and the first quality control product to be detected react to obtain a first quality control product to be detected;

in the reaction process of the first to-be-detected object, the sample collecting and distributing module is also used for sucking the second to-be-detected object, and the second detecting module is used for receiving the reagent conveyed by the reagent supplying module and the second to-be-detected object so as to enable the reagent to react with the second to-be-detected object to obtain a second to-be-detected object;

after the reaction of the first quality control object to be detected and the second quality control object to be detected is completed, the first detection module is further used for performing quality control measurement on the first quality control object to be detected, and the second detection module is further used for performing quality control measurement on the second quality control object to be detected.