CN117643680A - Electrode slice combination for tumor electric field therapeutic apparatus - Google Patents

Abstract

The application belongs to the technical field of medical equipment, and relates to the field related to tumor electric field treatment. The application discloses an electrode slice combination for a tumor electric field therapeutic apparatus, which is more convenient for attaching and using on the skin and ensures the therapeutic effect. Specifically, the electrode plate combination comprises at least 2 electrode plates, wherein a positioning groove is formed in a first electrode plate, a positioning part with a complementary shape with the positioning groove is formed in a second electrode plate, the positioning part can be embedded into the positioning groove, and the attaching position of the electrode plate can be determined through butt joint of the positioning groove and the positioning part; each electrode plate in the electrode plate combination is not connected and is independent. According to actual demands, each electrode slice in the electrode slice combination can be used independently or in combination. Any one electrode slice in the electrode slice combination can be matched and positioned according to the position of the other existing electrode slice, so that the attaching operation difficulty and cost are reduced, and the accurate attaching position and the accurate treatment effect are ensured.

Description

Electrode slice combination for tumor electric field therapeutic apparatus

Technical Field

The application belongs to the technical field of medical equipment, and particularly relates to the field of tumor electric field treatment. The application relates to an electrode slice combination for a tumor electric field therapeutic apparatus, which is more convenient for attaching and using on the skin and ensures the therapeutic effect.

Background

Treatment of cancer with a tumor therapeutic electric field ("TTField therapy"), which is a therapy performed by portable, noninvasive medical devices, is one of the leading edges of current research and development, and the principle is to apply an electric field of a specific frequency to tubulin of proliferating cancer cells, interfere with mitosis of the tumor cells, cause apoptosis of the affected cancer cells, and inhibit tumor growth.

The existing tumor electric field therapeutic apparatus mainly comprises an electric field generator and an electrode plate (namely an array of electrode elements, also called a transducer array) electrically connected with the electric field generator, wherein the electrode plate can transmit an alternating electric field. Electrode pads are placed on opposite sides of the body with intimate contact between the electrodes and the patient's skin and alternating voltages are applied between the opposite arrays at predetermined frequencies to generate the desired electric fields.

TTField therapy generally lasts for many months or even years, so that the electrode pad needs to be attached to the human skin as long as possible and needs to be attached tightly, however, the long-term wearing can have a great influence on the human skin, abnormal reactions such as local redness, ulcers, allergies and the like can occur to different degrees, and the affected skin parts can be recovered by changing the attaching positions periodically. In addition, since the electrode sheet product has a service life, the attached electrode sheet itself needs to be replaced periodically.

CN102389618A discloses an electrode for applying an electric field to a living body for a long period of time, the electrode being formed of a conductive substrate covered with a thin dielectric material, and a plurality of open spaces passing through the electrode, the distribution and size of these open spaces being such as to allow moisture located under the electrode to escape through the open spaces when the electrode is in contact with the patient's body, radiation and damage to the skin being minimized. The electrode pads still need to be periodically replaced every 2-4 days.

However, the replacement of the attached position requires a professional to operate, if the attached position is improper, the treatment effect of the tumor electric field treatment equipment is affected to different degrees, and if the professional is required to operate, the user needs to frequently go to a designated place to contact the professional for replacement, so that the convenience of use is greatly affected, and the use cost is also increased. At the same time, even the professionals cannot guarantee that each attachment is accurate, especially each time by a different professional.

In summary, if the attached position cannot be replaced regularly, the physical health of the user is affected, if the attached position is replaced regularly or the attached electrode sheet is replaced, a professional is required to operate, and the operation of a non-professional cannot ensure the accurate attached position, so that the treatment effect is reduced or the user is injured.

Disclosure of Invention

Aiming at the problems in the prior art, the application provides an electrode plate combination, which comprises at least 2 electrode plates, wherein a positioning groove is formed in a first electrode plate, a positioning part with a complementary shape with the positioning groove is formed in a second electrode plate, the positioning part can be embedded into the positioning groove, and the attachment position of the electrode plate can be determined through butt joint of the positioning groove and the positioning part; each electrode plate in the electrode plate combination is not connected and is independent.

The electrode patch can be connected with an electric field generator to be used as a tumor treatment electric field ("TTField therapy") for treating cancers, and each electrode sheet in the electrode sheet combination can be independently used or combined to be used according to actual requirements; two electrode sheets respectively provided with a positioning groove and a positioning portion may be used in combination, or a plurality of electrode sheets in the electrode sheet combination may be used in combination.

When the electrode plate combination is used in combination, a first electrode plate is attached, a second electrode plate is attached according to the attached position of the first electrode plate, and then the first electrode plate is taken down; optionally, the above operations may be repeated when replacement of the attached electrode sheet or replacement of the attached location is again required.

Preferably, the two electrode sheets are identical or similar in shape.

Each electrode plate in the electrode plate combination comprises a flexible circuit board assembly, wherein the flexible circuit board assembly comprises a flexible circuit board and electrode elements arranged on one side, facing skin, of the flexible circuit board, and a covering layer is arranged on one side, facing away from the skin, of the flexible circuit board. The cover layer is provided with 1 or more positioning grooves and/or positioning parts, and the number of the positioning grooves and/or the positioning parts can be 2, 3, 4, 5, 6, 7, 8 or more.

In one embodiment, the cover layer edge of the first electrode slice in the electrode slice combination forms a positioning groove, and the cover layer edge of the second electrode slice forms a positioning part with a complementary shape with the positioning groove.

Further, 1 or more positioning grooves are formed at one side edge of the cover layer of the first electrode sheet, and the number of the positioning grooves can be 2, 3, 4, 5, 6, 7, 8 or more; one side edge of the cover layer of the second electrode sheet forms 1 or more positioning parts with complementary shapes with 1 or more positioning grooves, and the positioning parts can be 2, 3, 4, 5, 6, 7, 8 or more positioning parts.

Further, the positioning groove and the positioning part are in a comb-shaped structure or a wedge-shaped structure which are meshed with each other.

In one embodiment, the shape of the cover layer of the first electrode slice in the electrode slice combination is the same as or similar to that of the flexible circuit board, and the cover layer completely covers the flexible circuit board; the shape of the cover layer of the second electrode plate is the same as or similar to that of the flexible circuit board, and the cover layer completely covers the flexible circuit board.

More specifically, the same or similar shape means that the flexible circuit board includes a trunk portion and a plurality of branch portions, and the cover layer also includes the trunk portion and the plurality of branch portions; the shapes of the trunk parts of the flexible circuit board and the covering layer are the same or similar; the shapes of the branch parts of the flexible circuit board and the cover layer are the same or similar, and the positions of the branch parts on the trunk part and the included angles of the branch parts and the trunk part are the same or similar; so that the cover layer completely covers the flexible circuit board. The branching portions on the flexible circuit board may be 2, 3, 4, 5, 6, 7, 8, or more.

Further, the flexible circuit board includes a trunk portion and a plurality of branch portions; one end of the plurality of branch parts is connected with the same side of the trunk part; the included angle between the branch part and the trunk part is 20-90 degrees; the plurality of branch parts are arranged along the length direction of the trunk part and form a comb-shaped structure together with the trunk part; the cover layer covers the trunk part and the plurality of branch parts of the flexible circuit board along the extending direction of the flexible circuit board; and a positioning groove corresponding to the shape of the branch parts is formed between two adjacent branch parts of the first electrode plate in the electrode plate combination, and one branch part of the second electrode plate is the positioning part, so that the first electrode plate and the second electrode plate in the electrode plate combination form a comb-shaped structure which is meshed with each other. One end of the trunk part is connected with a power supply cable. Preferably, the two electrode sheets are identical or similar in structure and shape.

Further, the first electrode sheet and the second electrode sheet in the electrode sheet combination each comprise two trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, and the first trunk part is connected with the tail end of the second trunk part through the extending end of the tail end branch part; the branch parts connected on the first trunk part and the branch parts connected on the second trunk part have the same extending direction; the first trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the second trunk portion of the second electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto.

Or alternatively

The first electrode plate and the second electrode plate in the electrode plate combination comprise three trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, the first trunk part is connected with the tail end of the second trunk part through the extending end of the tail end branch part, and the second trunk part is connected with the tail end of the third trunk part through the extending end of the tail end branch part; the extension directions of the branch part connected on the first trunk part, the branch part connected on the second trunk part and the branch part connected on the third trunk part are the same; the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate form an intermeshed comb-shaped structure with the third trunk part of the second electrode plate and the branch part connected with the third trunk part of the second electrode plate, and the second trunk part of the first electrode plate and the branch part connected with the second electrode plate form an intermeshed comb-shaped structure with the second trunk part of the second electrode plate and the branch part connected with the second electrode plate; the third trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb-like structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto.

Or alternatively

The first electrode plate and the second electrode plate in the electrode plate combination comprise two trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, and the first trunk part is connected with the front end of the second trunk part through the tail end branch part of the first trunk part; the branch part connected on the first trunk part and the branch part connected on the second trunk part have the same or opposite extending directions; the first trunk part of the first electrode slice and the branch part connected with the first trunk part of the first electrode slice form an intermeshed comb-shaped structure with the second trunk part of the second electrode slice and the branch part connected with the second trunk part of the second electrode slice, and the second trunk part of the first electrode slice and the branch part connected with the second electrode slice form an intermeshed comb-shaped structure with the first trunk part of the second electrode slice and the branch part connected with the second electrode slice; preferably, the first trunk portion is connected to the front end of the second trunk portion by an extension or middle of its terminal branch portion.

Further, the electrode elements are mounted to the trunk portion and the branch portion of the flexible circuit board.

Further, any one of the electrode sheets in the electrode sheet combination includes 24 electrode units arranged in 6 rows and 4 columns.

In one embodiment, in the electrode sheet combination described in the present application, a ring of oily paper is adhered along the edge of the cover layer of the electrode sheet, which is preferably a nonwoven fabric, at the edge of the side of the cover layer facing away from the skin.

The application is said for electrode slice combination, there is no interval between the first electrode slice and the second electrode slice.

The application also provides a use method of the electrode plate combination, when the electrode plate combination is used, the first electrode plate is attached, the second electrode plate is attached to a preset position through the comb-shaped structure which is meshed with each other, and the first electrode plate is removed after the second electrode plate is attached; optionally, the above operations may be repeated when electrode pads need to be replaced again or attachment locations need to be replaced.

In one embodiment, when the branch portion connected to the first trunk portion and the branch portion connected to the second trunk portion of each electrode sheet are opposite in extending direction;

when the electrode is combined, the first electrode plate is attached firstly, the second trunk part of the second electrode plate and the branch part connected with the second electrode plate are attached according to the positions of the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate, and the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate are taken down; attaching the first trunk part of the second electrode plate and the branch part connected with the first trunk part according to the positions of the second trunk part of the first electrode plate and the branch part connected with the second trunk part, and then removing the second trunk part of the first electrode plate and the branch part connected with the second trunk part; optionally, the above operations may be repeated when electrode pads need to be replaced again or attachment locations need to be replaced.

The present application also provides a tumor electric field treatment apparatus comprising: an electric field generating device for generating an alternating current signal; the electrode slice combination is the electrode slice combination, and the tumor electric field treatment equipment at least comprises 1 group of electrode slice combinations; any electrode plate in the electrode plate combination can be electrically connected with the electric field generating device; preferably, the tumor electric field treatment apparatus comprises at least 2 sets of said electrode sheet combinations.

The electrode plate combination has the following beneficial effects:

1. any one electrode plate can be matched and positioned according to the position of the other electrode plate, so that the attaching operation difficulty and cost are reduced, and the accurate attaching position and treatment effect are ensured.

2. The position change during the replacement of the electrode plates is controlled in a controllable range by the mutual non-interval complementary structure of the electrode plates, such as a comb-shaped structure, so that the treatment effect is ensured.

3. The comb-shaped structures formed by the flexible circuit boards of the first electrode plate and the second electrode plate are meshed with each other, no space is reserved between the comb-shaped structures, and long-time electric field treatment on a focus area can be ensured on the basis of avoiding adverse reactions when the electrode plates are replaced regularly or attached.

4. The oily paper is arranged at the edge of the back surface of the covering layer, so that the second electrode plate and the first electrode plate are prevented from being adhered to each other when the electrode plates are replaced.

Drawings

The advantages and benefits described herein, as well as other advantages and benefits, will become apparent to those of ordinary skill in the art upon reading the following detailed description of the exemplary embodiments. The drawings are only for purposes of illustrating exemplary embodiments and are not to be construed as limiting the application.

Fig. 1 is a schematic view of an electrode sheet assembly according to embodiment 1 of the present application.

Fig. 2 is a diagram showing the electrode sheet assembly according to embodiment 2 of the present application.

Fig. 3 is a schematic view of an electrode sheet assembly according to embodiment 3 of the present application.

Fig. 4 is a schematic view of an electrode sheet assembly according to embodiment 4 of the present application.

Fig. 5 is a schematic view of an electrode sheet assembly according to embodiment 5 of the present application.

DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION

Exemplary embodiments of the present disclosure will be described in more detail below, however, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

In the description of the embodiments of the present application, it should be understood that terms such as "comprises" or "comprising" are intended to indicate the presence of features, numbers, steps, acts, components, portions or combinations thereof disclosed in the present specification, and are not intended to exclude the possibility of the presence of one or more other features, numbers, steps, acts, components, portions or combinations thereof.

In the description of the present application, it should also be noted that, unless explicitly specified and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.

The terms "first," "second," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated.

The various features described herein may be combined in any suitable manner, without conflict, and the various possible combinations are not otherwise described herein in order to avoid unnecessary repetition. It should also be considered as disclosed herein, provided that it does not depart from the spirit of the present application.

In order to reduce adverse reactions of the electrode sheet to the skin, the patient needs to replace the electrode sheet after using one electrode sheet for a certain time, so that the place covered by the electrode sheet is not covered, and anaphylactic reactions caused by long-time stimulation of a certain position of the skin are avoided. However, when the attachment position is changed, the attachment position needs to be controlled to ensure the therapeutic effect. On the other hand, the attaching capability of the electrode plate can be affected in the replacement process, and the second attaching often generates the problem of infirm attaching, so that the problems of overhigh electrode temperature and poor treatment effect are caused; and therefore the electrode sheet also needs to be replaced periodically. Therefore, when the electrode plate is used for an electric field for tumor treatment, the requirement of changing the attachment position and the electrode plate exists at the same time.

The example embodiment of the application provides an electrode plate combination, which comprises at least 2 electrode plates, wherein a positioning groove is formed in a first electrode plate, a positioning part with a complementary shape with the positioning groove is formed in a second electrode plate, the positioning part can be embedded into the positioning groove, and the attachment position of the electrode plate can be determined through butt joint of the positioning groove and the positioning part; each electrode plate in the electrode plate combination is not connected and is independent.

According to actual requirements, each electrode slice in the electrode slice combination can be used independently or in combination; two electrode sheets respectively provided with a positioning groove and a positioning portion may be used in combination, or a plurality of electrode sheets in the electrode sheet combination may be used in combination.

When the electrode plate combination is used in combination, a first electrode plate is attached, a second electrode plate is attached according to the attached position of the first electrode plate, and then the first electrode plate is taken down; and when the attached electrode sheet needs to be replaced again, the above operation can be repeated.

Preferably, the electrode sheet combination in the application comprises 2 electrode sheets respectively provided with a positioning groove and a positioning part, and the two electrode sheets are not connected and are mutually independent.

The positioning groove and the positioning part are complementary or nearly complementary in shape, and the shape is not particularly limited, so long as the positioning groove and the positioning part are matched with each other, and the positioning function can be realized. The positioning groove can be of a concave structure, and the positioning part is a corresponding convex part. The shape of the protruding portion is not particularly limited, and may be square, rectangular, triangular, trapezoidal, semicircular, or other shapes, and the concave structure is a corresponding shape that can be complementary to the protruding portion to realize the positioning function.

Preferably, the two electrode sheets are identical or similar in shape.

Each electrode plate in the electrode plate combination comprises a flexible circuit board assembly, wherein the flexible circuit board assembly comprises a flexible circuit board and electrode elements arranged on one side, facing skin, of the flexible circuit board, and a covering layer is arranged on one side, facing away from the skin, of the flexible circuit board. The cover layer is preferably a nonwoven fabric. The electrode element is preferably a ceramic sheet. In the electrode sheet, foam is stuck around the electrode element of the flexible circuit board assembly, gel is stuck on the electrode element and the foam, and finally release paper is covered.

In one embodiment, 1 or more positioning grooves and/or positioning parts are arranged on the covering layer of the electrode plate, the positioning parts can be embedded into the positioning grooves, and the attachment position of the electrode plate is determined by means of the complementation of the shapes of the covering layers of the first electrode plate and the second electrode plate and the butt joint of the positioning grooves and the positioning parts.

Further, the edge of the cover layer of the first electrode plate forms a positioning groove, and the edge of the cover layer of the second electrode plate forms a positioning part with a complementary shape with the positioning groove.

Further, one side edge of the cover layer of the first electrode sheet is formed with 1 or more of the positioning grooves, and one side edge of the cover layer of the second electrode sheet is formed with a positioning portion having a complementary shape to the 1 or more positioning grooves. The positioning groove and the positioning part can be in a comb-shaped structure or a wedge-shaped structure which are meshed with each other.

When the electrode plates are combined, the first electrode plate with the cover layer edge forming the positioning groove is attached, the second electrode plate with the cover layer edge forming the positioning part is attached to a preset position through butt joint of the positioning part and the positioning groove, and the first electrode plate is removed after the second electrode plate is attached.

When the electrode plates are used, the first electrode plate needs to be removed and the second electrode plate is attached so that the area covered by the first electrode plate is exposed in order that the skin is not stimulated for a long time. However, in some cases, in order to ensure the therapeutic effect on tumor cells at a focal site, it is necessary to apply an electric field to the focal site for several days, months or longer, and thus it is necessary to control the difference between the positions of the first electrode sheet and the second electrode sheet before and after replacement within a certain range, so as to ensure that an electric field is continuously applied to the same focal site, and control the influence of the position variation of the electrode sheet during replacement on the therapy within a controllable range.

For this purpose, in one embodiment, the shape of the cover layer of the first electrode sheet in the electrode sheet combination described herein is the same or similar to that of the flexible circuit board, and the cover layer completely covers the flexible circuit board; the shape of the cover layer of the second electrode plate is the same as or similar to that of the flexible circuit board, and the cover layer completely covers the flexible circuit board. The cover layer and the flexible circuit board of the first electrode plate and the cover layer and the flexible circuit board of the second electrode plate form a positioning groove and/or a positioning part in structure and shape, and the positioning part can be embedded into the positioning groove to realize the position positioning when the electrode plates are attached.

More specifically, the same or similar shape means that the flexible circuit board includes a trunk portion and a plurality of branch portions, and the cover layer also includes the trunk portion and the plurality of branch portions; the shapes of the trunk parts of the flexible circuit board and the covering layer are the same or similar; the shapes of the branch parts of the flexible circuit board and the cover layer are the same or similar, and the positions of the branch parts on the trunk part and the included angles of the branch parts and the trunk part are the same or similar; so that the cover layer completely covers the flexible circuit board. The branching portions on the flexible circuit board may be 2, 3, 4, 5, 6, 7, 8, or more.

The flexible circuit board comprises a trunk part and a plurality of branch parts; one end of the plurality of branch parts is connected with the same side of the trunk part; the included angle between the branch part and the main part is 20-90 degrees, preferably 30-90 degrees, 40-90 degrees, 45-90 degrees, 50-90 degrees, 60-90 degrees, 70-90 degrees, 80-90 degrees and 85-90 degrees; the plurality of branch parts are arranged along the length direction of the trunk part and form a comb-shaped structure together with the trunk part; the cover layer covers the trunk part and the plurality of branch parts of the flexible circuit board along the extending direction of the flexible circuit board; and a positioning groove corresponding to the shape of the branch parts is formed between two adjacent branch parts of the first electrode plate in the electrode plate combination, and one branch part of the second electrode plate is the positioning part, so that the first electrode plate and the second electrode plate in the electrode plate combination form a comb-shaped structure which is meshed with each other. The electrode elements are mounted to the trunk portion and the branch portion of the flexible circuit board. One end of the trunk part is connected with a power supply cable. Preferably, the two electrode sheets are identical or similar in structure and shape. Each flexible circuit board may include 1 backbone portion, 2 backbone portions, 3 backbone portions.

Specifically, as shown in embodiment 1 of fig. 1, the first electrode sheet and the second electrode sheet each include a longitudinal trunk portion, a plurality of branch portions are connected to one side of the trunk portion, one end of each branch portion is connected to the trunk portion, the other end of each branch portion extends to the right side, the plurality of branch portions are arranged along the longitudinal direction of the trunk portion, and the trunk portion and the branch portions together form a comb-like structure. The comb-shaped structures of the first electrode plate and the second electrode plate are meshed with each other, and the mutual non-interval attaching and positioning functions can be realized during combined use.

In a specific embodiment, the first electrode sheet and the second electrode sheet in the electrode sheet combination each comprise two trunk portions arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, and the first trunk part is connected with the tail end of the second trunk part through the extending end of the tail end branch part; the branch parts connected on the first trunk part and the branch parts connected on the second trunk part have the same extending direction; the first trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the second trunk portion of the second electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto. Or the first electrode sheet and the second electrode sheet in the electrode sheet combination comprise three trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, the first trunk part is connected with the tail end of the second trunk part through the extending end of the tail end branch part, and the second trunk part is connected with the tail end of the third trunk part through the extending end of the tail end branch part; the extension directions of the branch part connected on the first trunk part, the branch part connected on the second trunk part and the branch part connected on the third trunk part are the same; the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate form an intermeshed comb-shaped structure with the third trunk part of the second electrode plate and the branch part connected with the third trunk part of the second electrode plate, and the second trunk part of the first electrode plate and the branch part connected with the second electrode plate form an intermeshed comb-shaped structure with the second trunk part of the second electrode plate and the branch part connected with the second electrode plate; the third trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb-like structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto.

Specifically, embodiment 2 is shown in fig. 2. Fig. 2- (1) shows that the side of the first electrode sheet facing the skin in the electrode sheet combination comprises a first main body part and a second main body part which are arranged in parallel, wherein the first main body part and the second main body part are connected with a plurality of branch parts on the same side, the extending direction of the branch parts on the first main body part is the same as that of the branch parts on the second main body part, the first main body part and the branch parts connected with the first main body part form a comb-shaped structure, and the second main body part and the branch parts connected with the second main body part form a comb-shaped structure; the end of the first trunk portion is connected to the power supply cable, and the first trunk portion is connected to the end of the second trunk portion through the extension end of the end branch portion thereof. Fig. 2- (2) shows that the side of the second electrode sheet facing the skin in the electrode sheet combination comprises a first main part and a second main part which are arranged in parallel, wherein the first main part and the second main part are connected with a plurality of branch parts on the same side, the extending direction of the branch parts on the first main part is the same as that of the branch parts on the second main part, the first main part and the branch parts connected with the first main part form a comb-shaped structure, and the second main part and the branch parts connected with the second main part form a comb-shaped structure; the front end of the first trunk portion is connected with the power supply cable, and the first trunk portion is connected with the end of the second trunk portion through the extending end of the end branch portion. The two electrode sheets are identical or similar in structure and shape. Fig. 2- (3) shows the side of the first electrode sheet and the second electrode sheet facing the skin when the first electrode sheet and the second electrode sheet are combined, and fig. 2- (4) shows the side of the first electrode sheet and the second electrode sheet facing away from the skin when the first electrode sheet and the second electrode sheet are combined, and it can be seen that the first trunk portion of the first electrode sheet and the branch portion connected thereto form a comb-like structure engaged with each other with the second trunk portion of the second electrode sheet and the branch portion connected thereto, and the second trunk portion of the first electrode sheet and the branch portion connected thereto form a comb-like structure engaged with each other. The attachment positioning function during combined use is realized through the comb-shaped structure of the mutual engagement between the first electrode plate and the second electrode plate.

In a specific embodiment, the first electrode sheet and the second electrode sheet in the electrode sheet combination each comprise two trunk portions arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, and the first trunk part is connected with the front end of the second trunk part through the tail end branch part of the first trunk part; the branch part connected on the first trunk part and the branch part connected on the second trunk part are the same or opposite to the extending direction of the trunk part; the first trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the second trunk portion of the second electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto. Preferably, the first trunk portion is connected to the front end of the second trunk portion by an extension or middle of its terminal branch portion. The electrode elements are mounted to the trunk portion and the branch portion of the flexible circuit board.

Specifically, as shown in embodiment 3 in fig. 3, the first electrode sheet and the second electrode sheet in the electrode sheet combination each include a first trunk portion and a second trunk portion arranged in parallel; the first trunk part and the second trunk part of the first electrode slice are connected with a plurality of branch parts on the same side, the extending direction of the branch part on the first trunk part is the same as the extending direction of the branch part on the second trunk part, and the first trunk part is connected with the front end of the second trunk part through the middle of the tail end branch part of the first trunk part; the first trunk part and the branch parts connected with the first trunk part form a comb-shaped structure, and the second trunk part and the branch parts connected with the second trunk part form a comb-shaped structure; the two electrode sheets are identical or similar in structure and shape. The first trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the second trunk portion of the second electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto. The attachment positioning function during combined use is realized through the comb-shaped structure of the mutual engagement between the first electrode plate and the second electrode plate.

As shown in specific embodiments 4-5 of fig. 4 and 5, the first electrode sheet and the second electrode sheet in the electrode sheet combination each include a first trunk portion and a second trunk portion arranged in parallel. The first trunk portion of the first electrode sheet is connected to the plurality of branch portions on the right side, the first trunk portion is connected to the front end of the second trunk portion through the extension ends of the terminal branch portions thereof, the second trunk portion is connected to the plurality of branch portions on the left side, the first trunk portion and the branch portions connected thereto form a comb-like structure, and the second trunk portion and the branch portions connected thereto form a comb-like structure. The first trunk portion of the second electrode sheet is connected to the plurality of branch portions on the right side, the first trunk portion is connected to the front end of the second trunk portion through the extension ends of the terminal branch portions thereof, the second trunk portion is connected to the plurality of branch portions on the left side, the first trunk portion and the branch portions connected thereto form a comb-like structure, and the second trunk portion and the branch portions connected thereto form a comb-like structure. The first trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the second trunk portion of the second electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto.

When the electrode sheet combinations of the specific embodiments 4 to 5 are used in combination, the first electrode sheet is attached first, then the second main part of the second electrode sheet and the branch part connected with the second main part are attached according to the positions of the first main part of the first electrode sheet and the branch part connected with the first main part, and the first main part of the first electrode sheet and the branch part connected with the first main part are removed; attaching the first trunk part of the second electrode plate and the branch part connected with the first trunk part according to the positions of the second trunk part of the first electrode plate and the branch part connected with the second trunk part, and then removing the second trunk part of the first electrode plate and the branch part connected with the second trunk part; optionally, the above operations may be repeated when electrode pads need to be replaced again or attachment locations need to be replaced. The attachment positioning function during combined use is realized through the comb-shaped structure of the mutual engagement between the first electrode plate and the second electrode plate.

When the electrode plate combination is used for attaching in a combined mode, no space exists between the two electrode plates, and position errors generated during repeated attaching are reduced. Especially when the flexible circuit board of the electrode plates of the first electrode plate and the second electrode plate forms a comb-shaped structure which is meshed with each other, no space exists between the two electrode plates during attachment, and long-time electric field treatment on a focus area can be ensured on the basis of periodically replacing the electrode plates or avoiding adverse reaction at the attachment position.

In a specific embodiment, when the electrode plates are combined, in order to avoid adhesion of the first electrode plate and the second electrode plate when the second electrode plate is attached, a circle of oily paper is adhered to the edge of one surface of the covering layer of the electrode plate, which is away from the skin, along the edge of the covering layer. The second electrode plate can be prevented from being attached to the covering layer of the first electrode plate by mistake when the second electrode plate is attached.

The application also provides a tumor electric field treatment device, which is characterized by comprising: an electric field generating device for generating an alternating current signal; the electrode slice combination comprises at least 1 group of electrode slice combination; any electrode plate in the electrode plate combination can be electrically connected with the electric field generating device; preferably, the tumor electric field treatment apparatus comprises at least 2 sets of said electrode sheet combinations.

While the spirit and principles of this application have been described with reference to several particular embodiments, it is to be understood that this application is not limited to the particular embodiments disclosed nor does it imply that features in the various aspects are not useful in combination, nor are they intended to be in any way useful for the purposes of this description. The application is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.

Claims (22)

1. The electrode plate combination is characterized by comprising at least 2 electrode plates, wherein a positioning groove is formed in a first electrode plate, a positioning part with a complementary shape with the positioning groove is formed in a second electrode plate, the positioning part can be embedded into the positioning groove, and the attachment position of the electrode plate can be determined through butt joint of the positioning groove and the positioning part; each electrode plate in the electrode plate combination is not connected and is independent.

2. The electrode sheet combination of claim 1, wherein each electrode sheet in the electrode sheet combination comprises a flexible circuit board assembly comprising a flexible circuit board and electrode elements mounted to a skin facing side of the flexible circuit board, the skin facing side of the flexible circuit board being provided with a cover layer.

3. The electrode sheet combination according to claim 2, wherein 1 or more of the positioning grooves and/or positioning portions are provided on the cover layer.

4. The electrode sheet assembly of claim 3 wherein the cover edge of the first electrode sheet forms a detent and the cover edge of the second electrode sheet forms a detent having a complementary shape to the detent.

5. The electrode sheet assembly of claim 4 wherein one side edge of the cover layer of the first electrode sheet forms 1 or more of said positioning grooves and one side edge of the cover layer of the second electrode sheet forms 1 or more of said positioning portions having a complementary shape to the 1 or more of said positioning grooves.

6. The electrode sheet combination according to claim 5, wherein the positioning groove and the positioning portion are of a comb-like structure or a wedge-like structure engaged with each other.

7. The electrode sheet combination according to claim 2, wherein the cover layer of the first electrode sheet in the electrode sheet combination is identical or similar in shape to the flexible circuit board, and the cover layer completely covers the flexible circuit board; the shape of the cover layer of the second electrode plate is the same as or similar to that of the flexible circuit board, and the cover layer completely covers the flexible circuit board.

8. The electrode sheet combination of claim 7 wherein the flexible circuit board includes a backbone portion and a plurality of branch portions; one end of the plurality of branch parts is connected with the same side of the trunk part; the included angle between the branch part and the trunk part is 20-90 degrees; the plurality of branch parts are arranged along the length direction of the trunk part and form a comb-shaped structure together with the trunk part; the cover layer covers the trunk part and the plurality of branch parts of the flexible circuit board along the extending direction of the flexible circuit board; and a positioning groove corresponding to the shape of the branch parts is formed between two adjacent branch parts of the first electrode plate in the electrode plate combination, and one branch part of the second electrode plate is the positioning part, so that the first electrode plate and the second electrode plate in the electrode plate combination form a comb-shaped structure which is meshed with each other.

9. The electrode sheet combination according to claim 8, wherein,

the first electrode plate and the second electrode plate in the electrode plate combination comprise two trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, and the first trunk part is connected with the tail end of the second trunk part through the extending end of the tail end branch part; the branch parts connected on the first trunk part and the branch parts connected on the second trunk part have the same extending direction; the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate form an intermeshed comb-shaped structure with the second trunk part of the second electrode plate and the branch part connected with the second trunk part of the second electrode plate, and the second trunk part of the first electrode plate and the branch part connected with the second electrode plate form an intermeshed comb-shaped structure;

or alternatively

The first electrode plate and the second electrode plate in the electrode plate combination comprise three trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, the first trunk part is connected with the tail end of the second trunk part through the extending end of the tail end branch part, and the second trunk part is connected with the tail end of the third trunk part through the extending end of the tail end branch part; the extension directions of the branch part connected on the first trunk part, the branch part connected on the second trunk part and the branch part connected on the third trunk part are the same; the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate form an intermeshed comb-shaped structure with the third trunk part of the second electrode plate and the branch part connected with the third trunk part of the second electrode plate, and the second trunk part of the first electrode plate and the branch part connected with the second electrode plate form an intermeshed comb-shaped structure with the second trunk part of the second electrode plate and the branch part connected with the second electrode plate; the third trunk part of the first electrode plate and the branch part connected with the third trunk part of the first electrode plate form an intermeshed comb-shaped structure with the first trunk part of the second electrode plate and the branch part connected with the first trunk part of the second electrode plate;

or alternatively

The first electrode plate and the second electrode plate in the electrode plate combination comprise two trunk parts which are arranged in parallel; a plurality of branch parts are arranged on the first side of each trunk part; one end of the first trunk part is connected with the power supply cable, and the first trunk part is connected with the front end of the second trunk part through the tail end branch part of the first trunk part; the branch part connected on the first trunk part and the branch part connected on the second trunk part have the same or opposite extending directions; the first trunk portion of the first electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the second trunk portion of the second electrode sheet and the branch portion connected thereto form an intermeshed comb structure with the first trunk portion of the second electrode sheet and the branch portion connected thereto.

10. The electrode sheet combination according to claim 8 or 9, wherein the electrode element is mounted to a trunk portion and a branch portion of the flexible circuit board.

11. The electrode sheet combination according to claim 10, wherein any one of the electrode sheets in the electrode sheet combination comprises 24 electrode units arranged in 6 rows and 4 columns.

12. The electrode sheet combination according to any one of claims 2-9, 11, wherein a ring of oily paper is adhered along the edge of the cover layer of the electrode sheet at the edge of the side facing away from the skin.

13. The electrode sheet combination of claim 12 wherein the cover layer is a nonwoven fabric.

14. The electrode sheet combination according to claim 10, wherein a ring of oiled paper is adhered along the edge of the cover layer of the electrode sheet on the side facing away from the skin.

15. The electrode sheet combination of claim 14 wherein the cover layer is a nonwoven fabric.

16. The electrode sheet combination of any one of claims 1-9, 11, 13-15, wherein there is no spacing between the first electrode sheet and the second electrode sheet.

17. The electrode sheet combination of claim 10, wherein there is no gap between the first electrode sheet and the second electrode sheet.

18. The electrode sheet combination of claim 12, wherein there is no gap between the first electrode sheet and the second electrode sheet.

19. The method of using an electrode sheet assembly according to any one of claims 1 to 18, wherein each electrode sheet can be used independently or in combination;

when the electrode is combined, the first electrode plate is attached firstly, the second electrode plate is attached later according to the position of the attached first electrode plate, and then the first electrode plate is taken down; optionally, the above operations may be repeated when electrode pads need to be replaced again or attachment locations need to be replaced.

20. The method of any one of claims 9-18, wherein when the branch portion of each electrode pad connected to the first trunk portion and the branch portion connected to the second trunk portion extend in opposite directions; each electrode sheet can be used independently or in combination;

when the electrode is combined, the first electrode plate is attached firstly, the second trunk part of the second electrode plate and the branch part connected with the second electrode plate are attached according to the positions of the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate, and the first trunk part of the first electrode plate and the branch part connected with the first trunk part of the first electrode plate are taken down; attaching the first trunk part of the second electrode plate and the branch part connected with the first trunk part according to the positions of the second trunk part of the first electrode plate and the branch part connected with the second trunk part, and then removing the second trunk part of the first electrode plate and the branch part connected with the second trunk part; optionally, the above operations may be repeated when electrode pads need to be replaced again or attachment locations need to be replaced.

21. A tumor electric field treatment apparatus, comprising:

an electric field generating device for generating an alternating current signal;

the electrode slice combination is the electrode slice combination of any one of claims 1-18, and the tumor electric field treatment equipment at least comprises 1 group of the electrode slice combination; any electrode plate in the electrode plate combination can be electrically connected with the electric field generating device.

22. The oncological electric field therapy device according to claim 21, wherein the oncological electric field therapy device comprises at least 2 sets of the electrode sheet combinations.