CN117619259A - Variable combination continuous double-screw wet granulation system - Google Patents
Variable combination continuous double-screw wet granulation system Download PDFInfo
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- CN117619259A CN117619259A CN202311758602.9A CN202311758602A CN117619259A CN 117619259 A CN117619259 A CN 117619259A CN 202311758602 A CN202311758602 A CN 202311758602A CN 117619259 A CN117619259 A CN 117619259A
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- 238000005550 wet granulation Methods 0.000 title claims abstract description 36
- 239000007788 liquid Substances 0.000 claims abstract description 138
- 239000011325 microbead Substances 0.000 claims abstract description 114
- 239000002245 particle Substances 0.000 claims abstract description 75
- 238000000034 method Methods 0.000 claims abstract description 42
- 239000011324 bead Substances 0.000 claims abstract description 34
- 239000000843 powder Substances 0.000 claims abstract description 31
- 239000003814 drug Substances 0.000 claims abstract description 30
- 230000008569 process Effects 0.000 claims abstract description 28
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 238000005469 granulation Methods 0.000 claims abstract description 24
- 230000003179 granulation Effects 0.000 claims abstract description 24
- 230000007423 decrease Effects 0.000 claims abstract description 4
- 239000000725 suspension Substances 0.000 claims description 76
- 239000011295 pitch Substances 0.000 claims description 42
- 238000007599 discharging Methods 0.000 claims description 41
- 238000004519 manufacturing process Methods 0.000 claims description 40
- 238000002347 injection Methods 0.000 claims description 37
- 239000007924 injection Substances 0.000 claims description 37
- 238000007789 sealing Methods 0.000 claims description 32
- 230000001105 regulatory effect Effects 0.000 claims description 16
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- 230000000712 assembly Effects 0.000 claims description 11
- 238000000429 assembly Methods 0.000 claims description 11
- 230000008859 change Effects 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
- 238000005096 rolling process Methods 0.000 claims description 11
- 238000007906 compression Methods 0.000 claims description 9
- 230000006835 compression Effects 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 239000006185 dispersion Substances 0.000 claims description 8
- 230000033228 biological regulation Effects 0.000 claims description 6
- 230000008878 coupling Effects 0.000 claims description 6
- 238000010168 coupling process Methods 0.000 claims description 6
- 238000005859 coupling reaction Methods 0.000 claims description 6
- 238000011897 real-time detection Methods 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 5
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- 239000000853 adhesive Substances 0.000 claims description 4
- 230000001070 adhesive effect Effects 0.000 claims description 4
- 238000005243 fluidization Methods 0.000 claims description 4
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- 238000012821 model calculation Methods 0.000 claims description 3
- 230000000737 periodic effect Effects 0.000 claims description 3
- 230000035485 pulse pressure Effects 0.000 claims description 3
- 230000008602 contraction Effects 0.000 claims description 2
- 229940126673 western medicines Drugs 0.000 claims description 2
- 238000005457 optimization Methods 0.000 abstract description 5
- 238000005516 engineering process Methods 0.000 description 19
- 230000006872 improvement Effects 0.000 description 15
- 238000002360 preparation method Methods 0.000 description 10
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- 210000003734 kidney Anatomy 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/22—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/10—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic in stationary drums or troughs, provided with kneading or mixing appliances
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/002—Nozzle-type elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/007—Feed or outlet devices as such, e.g. feeding tubes provided with moving parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/008—Feed or outlet control devices
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Glanulating (AREA)
Abstract
The invention discloses a variable combination continuous twin-screw wet granulation system, which comprises a granulation device, a granulation controller and a micro-droplet forming and injecting device, wherein the granulation controller is connected with the micro-droplet forming and injecting device; the granulating device comprises a variable combination shell assembly and a variable combination screw assembly; the variable combination screw assembly comprises a constant pitch frustum screw, a KE granulating module group and a conveying screw module. The invention not only realizes the function of precompression of raw material powder, but also can keep the capacity of granulating and conveying by arranging the constant pitch frustum screw; the variable combination shell assembly, the KE granulating module group, the conveying screw module and the length adjusting module are arranged, so that the variable combination shell assembly and the variable combination screw assembly can be subjected to length increase and decrease optimization combination according to different granulating processes; by arranging the micro-liquid bead forming and injecting device, continuous double-screw wet granulation of the traditional Chinese medicine high-viscosity extractum is realized; and by constructing a microbead particle size prediction model controller, online real-time control of the microbead particle size is realized.
Description
Technical Field
The invention relates to the technical field of continuous wet granulation of solid oral preparations, in particular to a variable combination continuous double-screw wet granulation system suitable for a traditional Chinese medicine high-viscosity extract granulation liquid.
Background
In the production of solid oral preparations, the solid oral preparation pelleting requires a wet granulation process. At present, the solid oral preparation is mainly produced in an intermittent batch production mode, and wet granulation is mainly carried out by adopting an intermittent batch stirring and mixing high-shear wet technology. With the continuous controllable manufacturing age of international solid oral preparations, continuous wet granulation technology and equipment are urgently needed. At present, the variable pitch continuous twin-screw wet granulation technology of Germany GEA company and the like mainly has the following main defects: (1) The continuous scientific quantitative traditional Chinese medicine high-viscosity extract micro-liquid bead injection technology is lacking, so that the continuous double-screw wet granulation method cannot be adapted to the high-viscosity extract traditional Chinese medicine oral preparation; (2) The KE granulating module, the granulating screw and the granulator housing of the existing continuous double-screw wet granulator lack variable combination functions, are difficult to adapt to the combined personalized variable combination process functions of the KE granulating module, the granulating screw and the granulator housing of different solid oral preparation processes, and the continuous double-screw wet granulator capable of realizing the variable combination functions of the granulator is urgently needed, so that the granulating process optimization is conveniently realized, the multiple purposes are realized, and the market demands of various and few-batch personalized flexible manufacturing are rapidly responded; (3) The existing continuous wet granulator adopts a variable pitch granulating screw structure with gradually reduced screw pitch to form the precompression function of raw material powder required in the wet granulation process, but the technical method with gradually reduced screw pitch of the granulating screw can realize the precompression function of the raw material powder, but the technical method has the cost of sacrificing the flow rate of conveying the powder by the screw, so that the granulating capacity of the screw is difficult to improve.
Disclosure of Invention
The invention provides a variable combination continuous double-screw wet granulation system, which aims to solve the technical problems that the existing continuous double-screw wet granulator lacks a traditional Chinese medicine high-viscosity extract granulation liquid micro-liquid bead forming and injection technology, cannot realize continuous double-screw wet granulation of a high-viscosity extract traditional Chinese medicine oral preparation, lacks a variable combination function, cannot adapt to market demands of multi-variety and small-batch personalized flexible manufacturing, and has poor process suitability of the existing variable-pitch screw precompression function, difficult granulation productivity improvement and the like.
In order to achieve the above purpose, the invention provides a variable combination continuous twin-screw wet granulation system, which is used for wet granulation of Chinese medicinal high-viscosity extract granulation liquid and wet granulation of western medicine granulation liquid, and is characterized in that: the device comprises a granulating controller, a granulating device, a micro-liquid bead forming and injecting device for high-viscosity granulating liquid of traditional Chinese medicine extract or a granulating liquid mixing and injecting device for western medicines;
the granulating device comprises a variable combination shell assembly and a variable combination screw assembly;
the variable combination shell assembly consists of a plurality of detachable modules, is convenient to detach, clean and optimize and combine in length, and comprises an upper shell, a lower shell and a length adjusting module, wherein the upper shell and the lower shell are surrounded to form a cuboid shell, the length adjusting module is arranged on the right side of the shell, and the length of the inner cavity of the variable combination shell assembly is adapted to the length of the variable combination screw assembly by changing the length adjusting modules with different length specifications;
The variable combination screw assembly is provided with two parts, the two parts are arranged in the variable combination housing assembly side by side, the left end of the variable combination screw assembly extends out of the variable combination housing assembly and is respectively connected with two output shafts of a homodromous conjugate meshing reduction gearbox driven by a variable frequency driving motor through a coupler, and the two variable combination screw assemblies are subjected to homodromous conjugate meshing rotation in the housing under the rotary driving of the variable frequency driving motor;
the variable combination screw assembly comprises a precompression unit arranged on the left side and a variable combination granulating unit arranged on the right side;
the precompression unit comprises a constant-pitch frustum screw rod, the constant-pitch frustum screw rod comprises a cylindrical section, a frustum screw rod section, a straight screw rod section and a hexagonal prism shaft section which are sequentially connected from left to right, the screw pitch of the frustum screw rod section is unchanged and equal to that of the straight screw rod section, the root diameter of the frustum screw rod section is a taper which gradually increases from left to right, the thread outer diameter of the frustum screw rod section is a taper which gradually decreases from left to right, and the thread depth of the frustum screw rod section is gradually decreased from left to right, so that raw material powder can be precompressed; the root diameter of the straight screw rod section is consistent with the root diameter of the right end of the frustum screw rod section, and the thread outer diameter of the straight screw rod section is consistent with the thread outer diameter of the right end of the frustum screw rod section;
The variable combination granulating unit is sleeved on the outer side surface of the hexagonal prism shaft section and comprises a first KE granulating module group, a first conveying screw module, a second KE granulating module group, a second conveying screw module, a third KE granulating module group and a supporting shaft sleeve which are sequentially connected from left to right, wherein the first KE granulating module group and the second KE granulating module group are respectively provided with a plurality of KE granulating modules, the first KE granulating module group and the second KE granulating module group can be used for optimally combining the disc numbers of the KE granulating modules according to different granulating processes, the appearance of the KE granulating modules is a fusiform with spiral propelling curved surfaces on the side surfaces, the screw pitches and the lengths of the first conveying screw module and the second conveying screw module can be optimally combined according to different granulating processes, and a thrust bolt is arranged on the right end surface of the hexagonal prism shaft section and can be used for axially positioning and fastening all parts of the variable combination screw assembly;
the left end of the upper side wall of the upper shell is provided with a feed inlet for feeding multicomponent raw material powder, and the left side of the upper side wall of the upper shell, which is arranged on the first KE granulating module group, is provided with a liquid inlet for granulating liquid; the micro-liquid bead forming and injection device is in sealing connection with a liquid outlet and a liquid inlet, or a granulating liquid injection nozzle of the granulating liquid mixing and injection device is in sealing connection with the liquid inlet;
The variable-frequency driving motor, the micro-liquid bead forming and injecting device or the granulating liquid mixing and injecting device are connected with the granulating controller.
As a further improvement of the technology, an infinite-shaped inner cavity formed by intersecting a front circular arc inner cavity and a rear circular arc inner cavity is formed in the middle of the inside of the shell, two variable combination screw components are coaxial with the two circular arc inner cavities of the infinite-shaped inner cavity respectively, the left side of the infinite-shaped inner cavity is a conical precompression chamber consistent with the taper of the conical thread outer diameter of the conical screw section, the right side of the infinite-shaped inner cavity is a straight-through shape matched with the screw thread outer diameter of the straight screw section, and the corresponding part of the infinite-shaped inner cavity and the variable combination granulating unit is provided with a granulating chamber.
As a further improvement of the technology, a gap of 0.2-0.4 mm is reserved between the thread outer diameter of the constant-pitch frustum screw and the corresponding inner side wall of the + -shaped inner cavity; the clearance between the thread outer diameter of one variable combination screw assembly and the corresponding root diameter of the other variable combination screw assembly in the two variable combination screw assemblies which are meshed in the same direction in a conjugate way is set to be 0.2-0.4 mm.
As a further improvement of the technology, the volume compression ratio of the first screw pitch of the large end and the first screw pitch of the small end of the external thread of the conical screw section is 1.5-2.5: 1.
As a further improvement of the technology, a hexagonal through hole matched with the appearance of the hexagonal prism shaft section is arranged in the center of the KE granulating module, and every two adjacent KE granulating modules in the first KE granulating module group and the second KE granulating module group are radially staggered by 60 degrees;
the root diameter and the thread outer diameter of the first conveying screw module and the second conveying screw module are consistent with those of the straight screw section, and hexagonal through holes matched with the shapes of the hexagonal prism shaft sections are formed in the centers of the first conveying screw module and the second conveying screw module;
and a hexagonal through hole matched with the hexagonal prism shaft section is formed in the support shaft sleeve.
As a further improvement of the technology, the variable combination screw assembly further comprises a rotary impeller, the rotary impeller is fixedly connected to the outer side face of the cylindrical section, four spiral propelling curved surface blades are uniformly distributed on the outer side face of the rotary impeller in a circumference mode, the four spiral propelling curved surface blades of the rotary impeller on the two variable combination screw assemblies form homodromous conjugate meshing rotary fit, and the variable combination screw assembly is used for carrying out pre-stirring and rapid dispersion mixing effects on multi-component raw material powder entering the shell, and meanwhile propelling the raw material powder to move forwards.
As a further improvement of the technology, four rectangular open grooves which are uniformly distributed circumferentially are arranged on the internal and external threads of the frustum screw section, which is 25-33% of the length range of the frustum screw section, of the constant-pitch frustum screw, and are used for carrying out rotary stirring, dispersion and fluidization on the multi-component raw material powder entering the inner cavity of the shell.
As a further improvement of the technology, the variable combination housing assembly further comprises a left bearing box, a discharging module, a right bearing box and a bearing end cover;
the left bearing box is connected with the left end head of the shell in a sealing way and is used for supporting the left shaft end of the variable combination screw assembly;
the discharging module is connected to the right side of the length adjusting module in a sealing way, a discharging hole is formed in the lower end of the discharging module and used for discharging end product particles, the right bearing box is connected to the right side of the discharging module in a sealing way and used for supporting a right end supporting shaft sleeve of the variable combination screw assembly, and the bearing end cover is connected to the right side of the right bearing box in a sealing way;
two locking screws are respectively arranged on the front side and the rear side of the right end face of the upper shell and the right end face of the lower shell, the four locking screws are uniformly distributed in an array, the locking screws sequentially penetrate through the length adjusting module, the discharging module, the right bearing box and the bearing end cover, the end parts are locked and fixed through locking nuts, and the variable combination shell components are fixedly connected in a sealing mode;
The supporting shaft sleeve sequentially penetrates through the discharging module, the right bearing box and the bearing end cover from left to right.
As a further improvement of the technology, the left bearing box is in a waist shape with a step at the right end, a step waist-shaped hole matched with the shape of the left bearing box is arranged at the left side of the ++shaped inner cavity in the shell, the left bearing box is clamped in the step waist-shaped hole, and the rotary impeller is arranged at the right side of the left bearing box;
the left end is equipped with the first infinity shape through-hole coaxial with the infinity shape inner chamber in the left bearing box, dislocation in the both sides circular arc hole of first infinity shape through-hole is provided with the antifriction bearing that corresponds the cylinder section cooperation fastening with two changeable combination screw rod subassemblies, the cylinder section excircle is fastened with this antifriction bearing inner circle, the right-hand member is equipped with two respectively with corresponding cylinder section excircle matched with first round hole in the left bearing box, first round hole and first infinity shape through-hole correspond side circular arc hole coaxial and be linked together.
As a further improvement of the technology, a first rectangular groove is formed in the right side of the + -shaped inner cavity in the shell, a first rectangular boss matched with the first rectangular groove is arranged on the left side surface of the length adjusting module, a second rectangular groove is formed in the right side surface of the length adjusting module, a second rectangular boss matched with the second rectangular groove is arranged on the left side of the discharging module, the first rectangular boss is clamped in the first rectangular groove, and the second rectangular boss is clamped in the second rectangular groove, so that the upper shell, the lower shell, the length adjusting module and the discharging module are in sealing connection;
The length adjusting module is provided with a second infinity-shaped through hole coaxial with the infinity-shaped inner cavity of the shell, the inner diameter of the second infinity-shaped through hole is consistent with the inner diameter of the right end of the infinity-shaped inner cavity, and the length adjusting module is used for prolonging the length of the infinity-shaped inner cavity of the shell after the variable combination screw assembly is lengthened due to the change of the granulating process, so that a variable combination granulating unit can partially enter the second infinity-shaped through hole, the length adjustment of the inner cavity of the shell is realized, and the variable combination screw assembly is suitable for the optimized combination of different granulating processes;
and a third infinity-shaped through hole coaxial with the circular arc-shaped inner cavities at two sides of the infinity-shaped inner cavity is arranged in the middle of the discharging module, and the discharging port is communicated with the third infinity-shaped through hole.
As a further improvement of the technology, a first infinity-shaped reaming coaxial with a third infinity-shaped through hole is arranged on the right side of the discharging module, a infinity-shaped stepped boss matched with the third infinity-shaped through hole and the first infinity-shaped reaming is arranged on the left side of the right bearing box, and the infinity-shaped stepped boss is inserted into the third infinity-shaped through hole and the first infinity-shaped reaming to enable the right bearing box to be in sealing connection with the discharging module;
the two sides in the ≡shaped stepped boss are respectively provided with a second round hole matched with the outer diameter of the supporting shaft sleeve, the right side of the right bearing box is provided with a second ≡shaped reaming coaxial with the ≡shaped stepped boss, the second ≡shaped reaming is communicated with the second round holes on the two sides, rolling bearings matched and fastened with the outer circular surfaces of the supporting shaft sleeve corresponding to the two variable combination screw components are arranged in the circular arc holes on the two sides of the second ≡shaped reaming in a staggered manner, and the outer circular surfaces of the supporting shaft sleeve are fastened with the inner ring of the rolling bearing;
The bearing end cover is characterized in that an infinity-shaped boss coaxial with the infinity-shaped inner cavity is arranged on the left side surface of the bearing end cover, the infinity-shaped boss is inserted into the infinity-shaped reamer hole of the second infinity-shaped reamer hole and fixedly connected with the right bearing box in a sealing way, third round holes matched with the outer circle of the supporting shaft sleeve are formed in two sides of the infinity-shaped boss, and the supporting shaft sleeve extends out of the third round holes, so that the flexible change of the axial installation position of the right bearing is ensured due to the free expansion and contraction of the length change of the variable combined screw assembly due to the optimized combination of different granulating processes.
As a further improvement of the technology, the length adjusting module, the discharging module, the right bearing box and the bearing end cover are all provided with U-shaped open slots matched with locking screws at the right end of the upper shell, and two locking screws at the right end of the upper shell penetrate through the U-shaped open slots to lock the variable combined shell assembly, and the U-shaped open slots enable the upper shell to be quickly installed, detached and cleaned in an inner cavity.
As a further improvement of the technology, the microbead forming and injecting device comprises a high-frequency pulse air inlet system, a granulating liquid conveying tank, a suspension conveying pipe, a microbead manufacturing pipe, a microbead injection pipe and a microbead particle size control system;
the high-frequency pulse air inlet system is connected with the granulating controller;
The granulating liquid conveying tank comprises an upper cover, a cylinder body and a lower cover which are sequentially connected from top to bottom, a high-frequency air inlet is inserted in the middle of the upper cover, and the high-frequency pulse air inlet system is in sealing connection with the high-frequency air inlet and is used for continuously conveying granulating liquid with high viscosity of the traditional Chinese medicine extract in the tank downwards in a high-frequency pulse manner; the device comprises a cylinder body, and is characterized in that an annular groove is formed in the lower end face of the cylinder body, a cylindrical boss is arranged in the middle of the bottom face of the annular groove, the height of the boss is smaller than the depth of the annular groove, a cylindrical pit is formed in the inner surface of the bottom of the cylinder body, a horn-shaped circular arc chamfer is formed at a pit opening, a hemispherical pit is formed in the middle of the bottom of the pit, a nipple is inserted in the middle of the hemispherical pit, a lower cover is arranged on the lower end face of the cylinder body, a gap of 0.2-0.5mm is reserved between the upper end face of the lower cover and the lower end face of the cylindrical boss, a suspension conveying pipe is inserted in the middle of the lower cover, the lower end of the nipple is inserted in the suspension conveying pipe, an annular gap is reserved between the outer side wall of the nipple and the inner side wall of the suspension conveying pipe, a first air inlet is formed in the outer side wall of the lower end of the cylinder body, the first air inlet is communicated with the annular groove, a suspension air cushion is arranged at the outer end of the first air inlet and is communicated with a compressed air inlet system, compressed air is used for inputting the compressed air into the annular groove, the annular gap forms an extremely short annular air flow passage, and forms a layer of air cushion in the annular flow passage in the conveying pipe, a layer, high-frequency pulse is conveyed to the suspension pipe, and an adhesive suspension is coated on the inner side of the suspension, and an adhesive suspension is coated on the suspension, and the suspension is prevented from being granulated;
The device comprises a micro-bead manufacturing tube, a micro-bead injection tube, a suspension conveying tube, a compression air inlet system, a suspension conveying tube, a compression air inlet system and a granulating liquid micro-bead injection tube, wherein the upper end of the micro-bead manufacturing tube is provided with an opening, an outwards extending flange is arranged on the outer side surface of the upper end, the upper end surface of the flange is fixedly connected with the lower end surface of the lower cover in a sealing manner, the micro-bead injection tube is inserted in the middle of the lower bottom wall of the micro-bead manufacturing tube in a sealing manner, the lower end opening of the micro-bead injection tube is provided with a horn-shaped outlet, the suspension conveying tube is sleeved in the micro-bead manufacturing tube, a narrow gap of 0.2-0.5mm is reserved between the lower end surface of the micro-bead injection tube and the upper end surface of the micro-bead injection tube, a traction breaking air inlet tube is arranged on the outer side wall of the upper end of the micro-bead manufacturing tube, the traction breaking air inlet tube is communicated with the interior of the micro-bead manufacturing tube, the outer end of the traction breaking air inlet system is communicated with the compressed air inlet system, and is used for inputting compressed air into the micro-bead manufacturing tube, the compression air is used for forming extremely short high-speed impact air flow at the narrow gap in the narrow gap, and continuously pulsing and breaking granulating liquid output from the suspension conveying tube, so that a necking granulating liquid is in the micro-bead injection tube, a small in the granulating hole, and a small particle size, and a particle.
The invention also provides a method for forming and injecting the micro-liquid beads, which is characterized in that: the method for forming and injecting the microbeads is a method for forming and injecting the microbeads by using the device for forming and injecting the microbeads in the granulating system, and comprises the following steps of:
(1) Firstly, compressed gas entering from a suspension air cushion air inlet pipe flows through an annular gap to form an annular suspension air cushion layer in a suspension conveying pipe; then under the drive of high-frequency circulating pulse pressure difference of a high-frequency pulse air inlet system, granulating liquid with high viscosity of the traditional Chinese medicine extract in a granulating liquid conveying tank sequentially passes through a hemispherical pit and a nipple, and flows into a suspension conveying pipe to form air cushion suspension conveying under the condition of wrapping an annular suspension air cushion layer;
(2) The granulating liquid conveyed by air cushion suspension flows out of the suspension conveying pipe and flows into the micro-droplet injection pipe through a narrow gap, when the traction breaking gas entering from the traction breaking air inlet pipe enters into the narrow gap, the traction breaking gas is induced to accelerate rapidly due to sudden shrinkage of the cross section of the flow passage, and local air flow high-speed impact is necessarily formed on the granulating liquid column flowing out of the suspension conveying pipe, so that the granulating liquid column flowing through the narrow gap is locally necked;
(3) The high-speed impact air flow flowing through the narrow gap flows into the micro-droplet injection tube, and forms annular air flow wrapping the granulating liquid column with local necking, and as the air flow speed is far greater than the flow speed of the wrapped granulating liquid column, the wrapped granulating liquid column is formed to have traction and stretching effects, so that the wrapped granulating liquid column is pulled and broken by necking at the necking position, and finally the granulating liquid micro-droplet is formed at the horn-shaped outlet;
(4) The granulating liquid microbeads formed in the step (3) are sprayed out from a trumpet-shaped outlet of a microbead injection tube, flow into an + -shaped inner cavity of the shell from a liquid inlet on the upper shell, are coupled through periodic high-frequency pulse transmission, so that continuous manufacturing of the granulating liquid microbeads with high viscosity of the traditional Chinese medicine extract is realized, and the granulating liquid microbeads are continuously output from the trumpet-shaped outlet and are continuously and quantitatively conveyed to a granulating chamber of the shell.
The invention also provides a microbead particle size control system, which is used for online real-time control of microbead particle sizes of continuous quantitative output of a microbead forming and injecting device in the granulating system, and is characterized in that: comprises a micro-droplet particle size prediction model controller and a traction breaking air inlet pipe air inlet flow rate control unit.
As a further improvement of the technology, the microbead particle size prediction model controller is constructed based on a microbead particle size and gas inlet flow rate cooperative coupling associated control prediction model of a traction stretch-break gas inlet pipe, and the associated control prediction model of the prediction model controller has a calculation formula as follows:
（1）
wherein d is the particle size of the liquid microsphere of the granulating liquid; v is the flow velocity of the gas inlet at the position of the traction breaking gas inlet pipe, and e is a natural constant;
Based on the associated control prediction model calculation formula (1), programming the embedded programming of the micro-droplet particle size model prediction controller on a granulating controller host, so that the micro-droplet particle size model prediction controller can realize the online real-time regulation and control of the particle size of the granulating liquid micro-droplet of the traditional Chinese medicine high-viscosity extractum by adjusting the gas inlet flow rate of the traction stretch-break air inlet pipe.
As a further improvement of the technology, the gas inlet flow rate control unit of the traction stretch-breaking air inlet pipe comprises a gas flow sensor, a flow controller and a proportion automatic regulating valve, wherein the gas flow sensor and the proportion automatic regulating valve are arranged on the traction stretch-breaking air inlet connecting pipe, the gas flow sensor and the proportion automatic regulating valve are both connected with the flow controller, the flow controller is connected with a micro-liquid bead particle size model prediction controller, and the gas flow sensor detects the air inlet flow of the traction stretch-breaking air inlet connecting pipe in real time and transmits the air inlet flow to the flow controller; the micro-droplet particle size model predictive controller sends a gas inlet flow set value control instruction to the flow controller, and the flow controller controls the opening of the proportional automatic regulating valve according to the deviation of the gas inlet flow set value and the real-time detection data, so as to realize the constant control of the inlet flow velocity of the traction stretch-break air inlet connecting pipe.
The invention also provides an online real-time control method for the particle size of the granulating liquid microbeads of the microbead size control system, which comprises the following steps:
s1, determining a particle size index of a granulating liquid microbead according to process requirements, calculating an optimal traction stretch-breaking air inlet pipe gas inlet flow velocity v required by meeting the particle size index of the granulating liquid microbead according to a formula (1) by a microbead size prediction model controller, sending an optimal gas inlet flow set value instruction to a flow controller, and automatically updating a flow set value of the flow controller;
s2, an air flow sensor detects the air inlet flow of the traction breaking air inlet pipe on line in real time, an electric signal of real-time air inlet flow detection is transmitted to a flow controller, and the flow controller controls the opening of a proportional automatic control valve according to the deviation of an air inlet flow set value and real-time detection data, so that the constant control of the inlet flow velocity of the traction breaking air inlet pipe is realized, and the on-line real-time regulation and control of the particle size of the micro-liquid beads of the granulating liquid is realized.
Compared with the prior art, the invention has the beneficial effects that:
1. according to the invention, by arranging the constant-pitch frustum screw, the screw pitch of the frustum screw section is unchanged, but the screw depth is gradually reduced from left to right, so that the function of precompression of raw material powder is realized, the powder conveying mass flow is kept constant, the defect that the powder conveying flow is reduced due to the existing variable-pitch screw conveying technical method is overcome, and the granulating production efficiency is greatly improved;
2. According to the invention, through the rapid installation and disassembly structural design of the rapid die combination of the variable combination screw assembly and the variable combination housing assembly, the variable combination screw assembly can freely increase and decrease the number of KE modules and optimally combine the screw pitches and lengths of the first conveying screw module and the second conveying screw module in the granulating chamber according to different granulating process requirements, the variable combination housing assembly, the length adjusting module and the screw supporting shaft sleeve are arranged to adapt to the screw length increase and the screw right end bearing axis installation position change caused by the screw variable combination required by the granulating process optimization, and the technical requirement of the granulating process optimization on the flexible and variable combination of the housing is realized, so that the granulating device provided by the invention has multiple purposes and can rapidly respond to the market demands of personalized flexible manufacturing with multiple varieties and few batches.
3. According to the invention, the micro-liquid bead forming and injecting device is arranged, so that the micro-liquid beads formed by the traditional Chinese medicine high-viscosity extract are continuously conveyed in a suspension manner, and are not adhered to the wall of the suspension conveying pipe in the conveying process, so that the micro-liquid beads can be continuously and scientifically and quantitatively conveyed to the granulating chamber in the shell, and the raw material powder after the micro-liquid beads are injected is further ground and pressed by combining the same-direction conjugate meshing rotation of two variable combination screws in the shell, so that particles are formed, and the continuous and efficient granulation of the high-viscosity extract traditional Chinese medicine oral preparation is realized;
4. According to the invention, through arranging two rotating impellers which are in same-direction conjugate meshing rotation and four rectangular open grooves which are uniformly distributed in circumference at the left end of the frustum screw section, the multi-component raw material powder entering the shell is subjected to the pre-stirring rapid dispersion mixing effect and the rotary stirring dispersion fluidization effect, and is cooperatively coupled with the inherent + 'infinity' shaped spiral mixing motion of the twin-screw in same-direction conjugate rotation of the granulating device, the mixing performance of the equal-pitch frustum screw mixing conveying can be further enhanced effectively, and the relative standard deviation RSD of the multi-component powder mixing uniformity of the granulating system is easy to meet the technical standard requirement that RSD is less than or equal to 5%.
5. According to the invention, through arranging the traction breaking air inlet pipe gas inlet flow rate control unit and the microbead particle size prediction model controller constructed based on the microbead particle size and traction breaking air inlet pipe gas inlet flow rate cooperative coupling association control prediction model, the microbead particle size of the traditional Chinese medicine high-viscosity extractum is finely regulated and controlled on line in real time, so that the microbead particle size always meets the microbead particle size set value expected by a user, the efficient and rapid uniform mixing of the microbeads of the traditional Chinese medicine high-viscosity extractum granulating liquid and the raw material powder is ensured, and the phenomenon that powder agglomeration is easy to occur due to uneven mixing in traditional intermittent batch high-shear mixing wet granulation is avoided.
Drawings
FIG. 1 is a schematic diagram of an embodiment of the present invention;
FIG. 2 is a schematic view of the internal structure of an embodiment of the present invention (with the upper housing removed);
FIG. 3 is a schematic diagram of an exploded construction of a variable combination continuous twin screw high shear wet granulation system according to an embodiment of the present invention;
FIG. 4 is a schematic view of a variable combination screw assembly according to an embodiment of the present invention;
FIG. 5 is a schematic view of the structure of a constant pitch frustum screw according to an embodiment of the present invention;
FIG. 6 is an enlarged view of the portion I of FIG. 5;
FIG. 7 is a schematic view of the assembly engagement gap of two variable combination screw assemblies and the assembly gap between the housing according to the embodiment of the present invention;
FIG. 8 is a schematic diagram of a granulating module according to an embodiment KE of the present invention;
FIG. 9 is a schematic view of a rotary impeller according to an embodiment of the present invention;
FIG. 10 is a schematic view of a conveyor screw module according to an embodiment of the present invention;
FIG. 11 is a schematic view of a left bearing housing according to an embodiment of the present invention;
FIG. 12 is a schematic view of a length adjustment module according to an embodiment of the present invention;
FIG. 13 is a schematic view of a discharging module according to an embodiment of the present invention;
FIG. 14 is a schematic view of the right bearing housing of the present invention;
FIG. 15 is a schematic view of a bearing housing cover according to an embodiment of the present invention;
FIG. 16 is a schematic view of a high viscosity bead forming and injecting apparatus according to an embodiment of the present invention;
FIG. 17 is an enlarged view of portion II of FIG. 16;
FIG. 18 is a schematic diagram showing a process of forming beads from a high viscosity extract according to an embodiment of the present invention;
FIG. 19 is a graph showing the relationship between the particle size of the first microbeads and the viscosity of the granulation liquid of the high-viscosity extract for Chinese medicine according to the embodiment of the present invention;
FIG. 20 is a graph showing a control model of the correlation between bead size and gas inlet flow rate of a pull-apart inlet tube according to an embodiment of the present invention.
In the figure: 1. the variable combination housing assembly, 11, upper housing, 1101, feed inlet, 1102, feed inlet, 12, lower housing, 1201, half-step kidney hole, 1202, half-infinity shaped inner cavity, 1203, half first rectangular groove, 13, left bearing housing, 1301, first infinity through hole, 1302, first round hole, 14, discharge module, 1401, second rectangular boss, 1402, third infinity through hole, 1403, discharge port, 1404, screw mounting hole, 1405, U-shaped open slot, 1406, first infinity counterbore, 15, right bearing housing, 1501, infinity shaped stepped boss, 1502, second round hole, 1503, screw mounting hole, 1504, U-shaped open slot, 1505, second infinity hole, 16, bearing end cap, 1601, + -shaped boss, 1602, third round hole, 1603, screw mounting hole, 1604, U-shaped open slot, 17, length adjustment module, 1701, first rectangular boss, 1702, second infinity through hole, 3, screw mounting hole, U-shaped open slot, 17018, second rectangular slot, locking groove, 17018;
2. The variable combination screw assembly comprises a variable combination screw assembly, 21, a constant pitch frustum screw, 211, a cylindrical section, 212, a frustum screw section, 212a, a large end first pitch, 212b, a small end first pitch, 2121, a rectangular open slot, 213, a straight screw section, 214, a hexagonal prism shaft section, 22, a rotary impeller, 221, a spiral propelling curved blade, 23, a first KE granulating module group, 231, a KE granulating module, 24, a first conveying screw, 25, a second KE granulating module group, 26, a second conveying screw, 27, a third KE granulating module group, 271, an end KE block, 28, a supporting shaft sleeve, 29 and a thrust bolt;
3. the micro-droplet forming and injecting device comprises a micro-droplet forming and injecting device 31, an upper cover 311, a high-frequency air inlet, 32, a cylinder body 3201, an annular groove 3202, a boss 3203, a rectangular pit 3204, a hemispherical pit 3205, a first air inlet 321, a nipple 322, a suspension air cushion air inlet pipe 33, a lower cover 331, a suspension conveying pipe 34, a micro-droplet manufacturing pipe 341, a micro-droplet injecting pipe 342, a traction stretch-breaking air inlet pipe 35, an annular gap 36 and a narrow gap.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," and the like indicate or are based on the orientation or positional relationship shown in the drawings, merely to facilitate description of the present invention and simplify the description, but do not indicate or imply that the devices or elements being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention
As shown in fig. 1, the first embodiment of the invention is a high viscosity extract variable combination continuous twin-screw wet granulation system for traditional Chinese medicine, comprising a granulation controller, a granulation device, and a microbead forming and injecting device 3, wherein the granulation device comprises a variable combination shell component 1 and a variable combination screw component 2.
As shown in fig. 2 and 3, the variable combination housing assembly 1 is composed of a plurality of detachable modules, is convenient to detach, clean and optimize and combine in length, and comprises an upper housing 11, a lower housing 12, a left bearing box 13, a length adjusting module 17, a discharging module 14, a right bearing box 15 and a bearing end cover 16, wherein the upper housing 11 and the lower housing 12 are surrounded to form a cuboid housing, an infinite-shaped inner cavity (see a half infinite-shaped inner cavity 1202 in fig. 3) formed by intersecting a front circular arc-shaped inner cavity and a rear circular arc-shaped inner cavity is formed in the middle of the housing, the left side of the infinite-shaped inner cavity is a cone with a large left end and a small right end, and the right side of the infinite-shaped inner cavity is a straight-through shape with the same two ends.
The left bearing box 13 is in a kidney-shaped shape with a step at the right end, a step kidney-shaped hole (see a half step kidney-shaped hole 1201 in fig. 3) matched with the shape of the left bearing box 13 is arranged at the left side of an ≡shaped inner cavity in the shell, the left bearing box 13 is clamped in the step kidney-shaped hole, a first ≡shaped through hole 1301 coaxial with the ≡shaped inner cavity of the shell is arranged at the left end in the left bearing box 13, two rolling bearings are arranged in circular arc holes at two sides of the first ≡shaped through hole 1301 in a staggered manner, the rolling bearings are axially positioned in a staggered manner through positioning shaft sleeves, the rolling bearings are used for supporting the left end of the variable combination screw assembly 2 in a conjugate meshing manner, and two first circular holes 1302 which are coaxial with and communicated with circular arc holes at corresponding sides of the first ≡shaped through hole 1301 are arranged at the right end in the left bearing box 13.
As shown in fig. 2, 3, 12 and 13, a first rectangular groove (see a half first rectangular groove 1203 in fig. 3) is arranged on the right side of the +.3-shaped inner cavity in the shell, a first rectangular boss 1701 matched with the first rectangular groove is arranged on the left side surface of the length adjusting module 17, a second rectangular groove 1705 is arranged on the right side surface of the length adjusting module, a second rectangular boss 1401 matched with the second rectangular groove 1705 is arranged on the left side of the discharging module 14, the first rectangular boss 1701 is clamped in the first rectangular groove, the second rectangular boss 1401 is clamped in the second rectangular groove 1705, and the upper shell 11, the lower shell 12, the length adjusting module 17 and the discharging module 14 are in sealing connection;
The middle of the length adjusting module 17 is provided with a second infinity-shaped through hole 1702 which is coaxial with the infinity-shaped inner cavity of the shell, the inner diameter of the second infinity-shaped through hole 1702 is consistent with the inner diameter of the right end of the infinity-shaped inner cavity, and the length adjusting module is used for prolonging the length of the infinity-shaped inner cavity of the shell after the variable combination screw assembly 2 is lengthened due to the change of the granulating process, so that a variable combination granulating unit can partially enter the second infinity-shaped through hole 1702, the length adjustment of the shell is realized, and the variable combination screw assembly is suitable for the optimized combination of different granulating processes;
the length of the length adjusting module 17 is equal to the length of the shell which needs to be lengthened after the variable combination screw assembly 2 is optimally combined according to the granulating process, and the length adjusting module 17 with different lengths can adapt to the length change of the inner cavity of different granulating processes by changing, so that the shell is suitable for the market demand of personalized flexible manufacturing with multiple varieties and few batches.
The middle of the discharging module 14 is provided with a third infinity-shaped through hole 1402 which is coaxial with the circular arc inner cavities at two sides of the infinity-shaped inner cavity, the bottom of the discharging module 14 is provided with a discharging hole 1403 which is communicated with the third infinity-shaped through hole 1402 and is used for discharging end product particles, and the right side of the discharging module 14 is provided with a first infinity-shaped reaming 1406 which is coaxial with the third infinity-shaped through hole 1402.
As shown in fig. 14, the left side of the right bearing housing 15 is provided with an ≡shaped stepped boss 1501 which is matched with the third ≡shaped through hole 1402 and the first ≡shaped counterbore 1406, and the fact-shaped stepped boss 1501 is inserted into the third ≡shaped through hole 1402 and the first ≡shaped counterbore 1406 to seal and connect the right bearing housing 15 with the discharging module 14.
The two sides in the infinity-shaped stepped boss 1501 are respectively provided with a second round hole 1502, the right bearing box 15 is internally provided with a second infinity-shaped reaming 1505 which is coaxial with the infinity-shaped stepped boss 1501, the second infinity-shaped reaming 1505 is communicated with the second round holes 1502 on the two sides, two rolling bearings are arranged in the circular arc cavities on the two sides of the second infinity-shaped reaming 1505 in a staggered manner and are used for supporting the right end supporting shaft sleeve 28 of the two same-direction conjugate meshed variable combination screw assemblies 2.
As shown in fig. 15, a ≡shaped boss 1601 coaxial with the ≡shaped cavity is provided on the left side surface of the bearing cap 16, and the ≡shaped boss 1601 is inserted into the second ≡shaped counterbore 1505 and is fixedly connected with the right bearing housing 15 in a sealing manner.
And third round holes 1602 are arranged on two sides of the infinity-shaped boss 1601.
As shown in fig. 2 and 4, the variable combination screw assembly 2 is provided with two parts, which are respectively coaxial with the front circular arc inner cavity and the rear circular arc inner cavity of the + -shaped inner cavity, the input ends of the two parts of variable combination screw assembly 2 extend out of the left bearing box 13 to be respectively connected with two output shafts of a same-direction conjugate meshing reduction gear box (not shown) driven by a variable frequency driving motor, under the rotary drive of a variable frequency drive motor, the two variable combination screw assemblies 2 are in the same-direction conjugate meshing rotation in the shell; the outer circles at the left and right ends of the variable combination screw assembly 2 are respectively fastened with the inner rings of the rolling bearings in the left bearing box 13 and the right bearing box 15.
The variable combination screw assembly 2 comprises a precompression unit arranged on the left side and a variable combination granulation unit arranged on the right side;
the precompression unit comprises a constant pitch frustum screw 21;
as shown in fig. 5, the constant pitch frustum screw 21 includes a cylindrical section 211, a frustum screw section 212, a straight screw section 213 and a hexagonal prism shaft section 214 which are connected in this order from left to right, and the pitch of the frustum screw section 212 is unchanged and equal to the pitch of the straight screw section 213.
The cylindrical section 211 passes through the left bearing box 13 and is fastened with the inner ring of the rolling bearing in the left bearing box 13, the left end head is connected with the output shaft of the same-direction conjugate meshing reduction gearbox through a coupler, and a first round hole 1302 in the left bearing box 13 is matched and sealed with the outer diameter of the cylindrical section 211, so that raw material powder can be prevented from entering the left bearing box 13.
The root diameter of the frustum screw section 212 is gradually increased from left to right, the thread outer diameter of the frustum screw section 212 is gradually decreased from left to right, the thread depth of the frustum screw section 212 is gradually decreased from left to right, and the volume compression ratio of the large-end first thread pitch 212a to the small-end first thread pitch 212b of the external thread of the frustum screw section 212 is 1.5-2.5: 1, thereby can produce precompression function to raw materials powder, because the pitch is unchangeable, make the transportation production ability of raw materials powder invariable, solved among the prior art variable pitch precompression and carried the problem that can lead to carrying the productivity to reduce gradually, in the casing the left side tapering of +'s shape inner chamber is unanimous with the screw thread external diameter tapering of frustum screw rod section 212.
The root diameter of the straight screw section 213 is identical to the right end root diameter of the frustum screw section 212, and the thread outer diameter of the straight screw section 213 is identical to the right end thread outer diameter of the frustum screw section 212.
The variable combined granulating unit is sleeved on the outer side surface of the hexagonal prism shaft section 214 and comprises a first KE granulating module group 23, a first conveying screw module 24, a second KE granulating module group 25, a second conveying screw module 26, a third KE granulating module group 27 and a supporting shaft sleeve 28 which are sequentially connected from left to right.
The left side of the infinity-shaped inner cavity is a conical precompression chamber consistent with the conical external diameter of the conical screw thread of the frustum screw section 212, the right side of the infinity-shaped inner cavity is a straight-through shape matched with the external diameter of the screw thread of the straight screw section 213, and the corresponding part of the infinity-shaped inner cavity and the variable combination granulating unit is a granulating chamber.
As shown in fig. 7, a clearance S2 of 0.2-0.4 mm is reserved between the thread outer diameter of the variable combination screw assembly 2 and the inner side wall of the +.y-shaped inner cavity in the shell; the clearance S1 between the thread outer diameter of one variable combination screw assembly 2 and the root diameter of the other variable combination screw assembly 2 in the two variable combination screw assemblies 2 which are meshed in the same direction in a conjugate way is set to be 0.2-0.4 mm.
As shown in fig. 4, the first KE granulating module group 23 and the second KE granulating module group 25 are respectively provided with a plurality of KE granulating modules 231, and the number of the KE granulating modules 231 can be increased or decreased according to different granulating processes for optimization combination;
The external shape of the KE granulating module 231 is a fusiform with a spiral propelling curved surface on the side (as shown in fig. 8), hexagonal through holes matched with the external shape of the hexagonal prism shaft section 214 are formed in the center of the KE granulating module, and the first KE granulating module group 23 and the second KE granulating module group 25 are sleeved with the hexagonal prism shaft section 214 through the hexagonal through holes, and every two adjacent KE granulating modules 231 are radially staggered by 60 degrees.
The third KE granulation module group 27 comprises two end KE blocks 271, wherein the appearance of each end KE block 271 is identical to that of the KE granulation module 231, and the two end KE blocks 271 are radially staggered by 90 degrees.
The root diameter and the thread outer diameter of the first conveying screw module 24 and the second conveying screw module 26 are consistent with those of the straight screw section 213, the thread pitch and the screw length can be optimally combined according to different granulating processes, hexagonal through holes matched with the shapes of the hexagonal prism shaft sections 214 are formed in the centers of the first conveying screw module 24 and the first conveying screw module 26, and the first conveying screw module 24 and the first conveying screw module 26 are sleeved with the hexagonal prism shaft sections 214 through the hexagonal through holes.
A hexagonal through hole matched with the hexagonal prism shaft section 214 is formed in the support shaft sleeve 28, and the support shaft sleeve 28 is sleeved with the hexagonal prism shaft section 214 through the hexagonal through hole; the second circular aperture 1502 and the third circular aperture 1602 each have an inner diameter that matches the outer diameter of the support sleeve 28.
Preferably, the variable combination screw assembly 2 further comprises a rotary impeller 22 (as shown in fig. 9), the rotary impeller 22 is fixedly connected to the outer side surface of the cylindrical section 211 and is arranged on the right side of the left bearing box 13, four spiral propelling curved surface blades 221 are uniformly distributed on the outer side surface of the rotary impeller 22 in a circumferential manner, the four spiral propelling curved surface blades 221 of the rotary impeller 22 on the two variable combination screw assemblies 2 form the same-direction conjugate meshing fit, and the variable combination screw assembly is used for carrying out the pre-stirring and rapid dispersion mixing effects on the multi-component raw material powder entering the shell, so that the conveying and mixing effects of the constant-pitch frustum screw 21 are enhanced, and the multi-component raw material powder is more uniformly mixed.
Preferably, four rectangular open grooves 2121 (as shown in fig. 6) uniformly distributed circumferentially are formed in the internal and external threads of the variable diameter screw 212 of the constant pitch frustum screw 21 in a range of 25-33% of the length of the frustum screw 212, so as to perform rotary stirring dispersion fluidization on the multi-component raw material powder, further enhance the conveying and mixing effects of the constant pitch frustum screw 21 and enable the multi-component raw material powder to be mixed more uniformly.
As shown in fig. 4, a thrust bolt 29 is arranged on the right end surface of the six-prism shaft section 214, and all parts of the variable combination screw assembly 2 can be axially positioned and fastened by tightening the thrust bolt 29; the outer circle of the supporting shaft sleeve 28 is fastened with the inner ring of the rolling bearing in the right bearing box 15 and extends out of the third round hole 1602 for a certain length, so that the free extension and retraction of the variable combination screw assembly 2 due to the length change of the optimized combination of different granulation processes and the flexible change of the axial installation position of the right bearing are realized.
As shown in fig. 3, a feeding port 1101 for multicomponent raw material powder is arranged at the left end of the upper side wall of the upper shell 11, and a liquid inlet 1102 for granulating liquid is arranged at the left side of the first KE granulating module group 23 on the upper side wall; .
Two locking screws 18 are arranged on the front side and the rear side of the right end face of the upper shell 11 and the right end face of the lower shell 12, and four locking screws 18 are uniformly distributed in an array;
as shown in fig. 12, 13, 14 and 15, the upper end of the length adjusting module 17 is provided with two U-shaped open slots 1704 matched with the locking screw 18, the lower end is provided with two screw mounting holes 1703 matched with the locking screw 18, the upper end of the discharging module 14 is provided with two U-shaped open slots 1405 matched with the locking screw 18, and the lower end is provided with two screw mounting holes 1404 matched with the locking screw 18; the upper end of the right bearing box 15 is provided with two U-shaped open grooves 1504 matched with the locking screw 18, and the lower end is provided with two screw mounting holes 1503 matched with the locking screw 18; the upper end of the bearing end cover 16 is provided with two U-shaped open grooves 1604 which are matched with the locking screw 18, and the lower end is provided with two screw mounting holes 1603 which are matched with the locking screw 18;
the invention has the advantages that the U-shaped open slot is arranged, so that the upper shell 11 can be quickly assembled and disassembled, the optimal combination of the variable combination shell component 1 and the variable combination screw component 2 and the cleaning after working are convenient, and the granulating production efficiency is improved;
As shown in fig. 1, 2 and 3, two locking screws 18 at the right end of the upper shell 11 respectively pass through the U-shaped open grooves 1704, 1405, 1504 and 1604, and the ends are locked by locking nuts; two locking screws 18 at the right end of the lower housing 12 respectively penetrate through screw mounting holes 1703, 1404, 1503 and 1603, and the ends are locked by locking nuts to fixedly connect the variable combination housing assembly 2 in a sealing manner.
According to the invention, the shell is arranged into the variable combination shell assembly 1, so that the variable combination screw assembly 2 can be conveniently disassembled and cleaned, and can be conveniently and optimally combined according to different granulating processes, thereby realizing multiple purposes, adapting to the market demands of personalized flexible manufacturing with multiple varieties and few batches, and greatly improving the practicability of the granulating system.
As shown in fig. 16 and 17, the bead forming and injecting apparatus 3 includes a high-frequency pulse air intake system, a granulation liquid conveying tank, a suspension conveying pipe 331, a bead manufacturing pipe 34, a bead injection pipe 341, and a bead particle diameter control system;
the granulating liquid conveying tank comprises an upper cover 31, a cylinder 32 and a lower cover 33 which are sequentially connected from top to bottom, a high-frequency air inlet 311 is inserted in the middle of the upper cover 31, and a high-frequency pulse air inlet system is in sealing connection with the high-frequency air inlet 311 and is used for continuously and pulse conveying the granulating liquid of the traditional Chinese medicine high-viscosity extractum in the tank downwards; the lower end face of the barrel 32 is provided with a ring groove 3201, a cylindrical boss 3202 is arranged in the middle of the groove bottom face of the ring groove 3201, the boss 3202 is smaller than the depth of the ring groove 3201, a cylindrical pit 3203 is arranged on the inner surface of the bottom of the barrel 32, a horn-shaped circular arc chamfer is arranged at the upper port of the pit 3203, a hemispherical pit 3204 is arranged in the middle of the bottom of the pit 3203, a nipple 321 is inserted in the middle of the hemispherical pit 3204, a lower cover 33 is arranged on the lower end face of the barrel 32, a gap h1=0.2-0.5 mm is reserved between the upper end face of the lower cover and the lower end face of the boss 3202, a suspension conveying pipe 331 is inserted in the suspension conveying pipe 331, an annular gap 35 is reserved between the outer side wall of the nipple 321 and the inner side wall of the suspension conveying pipe 331, a first air inlet 3205 is arranged on the outer side wall of the lower end of the barrel 32, the first air inlet 3205 is communicated with the ring groove 3201, an air inlet pipe 322 is arranged at the outer end and is communicated with a compressed air system, compressed air is used for inputting the compressed air into the ring groove 3201, a very-shaped air channel is formed at the position of the annular gap 35, a very-shaped air inlet channel is reserved between the upper end face of the lower cover and the boss 3202, a high-frequency adhesive layer is reserved between the suspension fluid suspension is high-adhesive layer, and is coated in the suspension is high, and is well adhered to the suspension is conveyed by the suspension, and is well in the suspension is well in the granulating layer, and is well in the suspension is well in the high-frequency, and is well in the granulating, and is well in the suspension is well in the state, and is well in the suspension is well and is well in the state;
The upper end of the microbead manufacturing tube 34 is opened, an outward extending flange is arranged on the outer side surface of the upper end, the upper end surface of the flange is fixedly connected with the lower end surface of the lower cover 33 in a sealing way, the microbead injection tube 341 is inserted in the middle of the lower bottom wall of the microbead manufacturing tube 34 in a sealing way, the orifice of the lower end of the microbead injection tube 341 is provided with a horn-shaped outlet, the suspension conveying tube sleeve 331 is arranged in the microbead manufacturing tube 34, a narrow gap 36 with h2=0.2-0.5 mm is reserved between the lower end surface and the upper end surface of the microbead injection tube 341, a traction breaking air inlet tube 342 is arranged on the outer side wall of the upper end of the microbead manufacturing tube 34, the traction breaking air inlet tube 342 is communicated with the interior of the microbead manufacturing tube 34, the outer end is communicated with a compressed air inlet system and is used for inputting compressed air into the microbead manufacturing tube 34, the compressed air forms extremely short high-speed impact air flow at the narrow gap 36, a necking traction breaking effect is generated on the high-extract granulating liquid which is continuously pulsed and suspended and output from the suspension conveying tube 331, so that the high-viscosity extract granulating liquid is formed into a granulating liquid shell of the microbead manufacturing tube 341, and the granulating liquid is continuously arranged in the granulating chamber 1102;
The high-frequency pulse air inlet system comprises a compressed air storage tank, an air filter, a high-frequency two-position three-way reversing electromagnetic valve and an intelligent circulation time relay, compressed air sequentially flows through an outlet of the compressed air storage tank, the air filter, the high-frequency two-position three-way reversing electromagnetic valve and the high-frequency pulse air inlet, and the continuous adjustable high-frequency pulse air inlet of the micro-liquid bead formation and injection device is realized by regulating and controlling the time of the intelligent circulation time relay;
the variable frequency driving motor and the high frequency pulse air inlet system are connected with the granulating controller.
As shown in fig. 18, a bead forming and injecting method of a bead forming and injecting device 3 according to a first embodiment of the present invention includes the following steps:
(1) Firstly, compressed air entering from the suspension air cushion air inlet pipe 322 flows through the annular gap 35 to form an annular suspension air cushion layer in the suspension conveying pipe 331; then under the drive of high-frequency circulating pulse pressure difference of a high-frequency pulse air inlet system, the high-viscosity extract granulating liquid in the granulating liquid conveying tank sequentially passes through the hemispherical pit 3204 and the nipple 321, and flows into the suspension conveying pipe 331 to form air cushion suspension conveying under the condition of wrapping an annular suspension air cushion layer;
(2) The granulating liquid conveyed by air cushion suspension flows out of the suspension conveying pipe 331 and flows through the narrow gap 36 into the microbead injection pipe 341, at the moment, when the traction breaking gas entering from the traction breaking gas inlet pipe 342 enters into the narrow gap 36, the traction breaking gas is induced to accelerate rapidly due to sudden shrinkage of the flow passage section, and local air flow high-speed impact is necessarily formed on the granulating liquid column flowing out of the suspension conveying pipe 331, so that the granulating liquid column flowing through the narrow gap 36 is locally necked;
(3) The high-speed impact air flow flowing through the narrow gap 36 flows into the microbead injection tube 341 and forms annular air flow wrapping the granulating liquid column with local necking, and as the air flow speed is far greater than the flow speed of the wrapped granulating liquid column, the wrapped granulating liquid column is formed to have traction and stretching effects, so that the wrapped granulating liquid column is pulled and broken by necking at the necking position, and finally, microbeads are formed at the horn-shaped outlet;
(4) The microbeads formed in the step (3) are sprayed out from the trumpet-shaped outlet of the microbead injector 341, flow into the + -shaped inner cavity of the shell from the liquid inlet 1102 on the upper shell, are coupled through the periodic high-frequency pulse transmission function, so that continuous manufacturing of the high-viscosity extractum granulating liquid microbeads is realized, and are continuously output from the trumpet-shaped outlet and continuously and quantitatively conveyed to the granulating chamber of the shell.
Fig. 19 is a graph showing the relationship between the particle size of the microbeads and the viscosity of the high-viscosity extract-type granulating liquid manufactured by the microbead forming and injecting device 3, and the result shows that the device can prepare the microbeads with 1050 [ mu ] m to 1100 [ mu ] m under the condition that the viscosity is lower than 100Pa.s, and the general saccharide melt viscosity is about 5Pa.s, so that the microbead forming and injecting device 3 can realize continuous manufacturing and quantitative micro-constant conveying of the microbeads of the high-viscosity extract-type granulating liquid, and provides technical support for continuous double-screw wet granulation of the high-viscosity extract-type granulating liquid solid oral preparation particles for traditional Chinese medicines.
Multiple experiments prove that the smaller the particle size of the micro-liquid beads is, the more uniform the distribution of the micro-liquid beads in the raw material powder is, so that the particle size of the final particle product of the granulating system of the patent is more uniform, the higher the granulating yield is, and therefore, the particle size of the micro-liquid beads needs to be regulated and controlled.
The invention provides a microbead particle size control system of a microbead forming and injecting device 3, which comprises a microbead particle size prediction model controller and a traction breaking air inlet pipe gas inlet flow rate control unit.
The microbead particle size model predictive controller is constructed based on a microbead particle size and gas inlet flow velocity collaborative coupling association control predictive model at a traction stretch-break gas inlet pipe.
As shown in fig. 20, in the first embodiment of the present invention, a cooperative coupling association control prediction model of the particle size of the micro-droplets and the gas inlet flow rate of the traction stretch-break gas inlet pipe is established on a host computer of a granulation controller, and multiple experiments show that the association control prediction model presents Boltzmann function evolution rules, so as to obtain a calculation formula of the cooperative coupling association control prediction model:
（1）/>
wherein d is the particle size of the liquid microsphere of the granulating liquid; v is the flow velocity of the gas inlet at the position of the traction breaking gas inlet pipe, and e is a natural constant;
Based on the associated control prediction model calculation formula (1), programming the embedded programming of the micro-droplet particle size model prediction controller on a granulating controller host, so that the micro-droplet particle size model prediction controller can realize the online real-time regulation and control of the particle size of the granulating liquid micro-droplet of the traditional Chinese medicine high-viscosity extractum by adjusting the flow rate of the gas inlet of the traction stretch-break air inlet pipe.
The traction breaking air inlet pipe gas inlet flow rate control unit comprises a gas flow sensor, a flow controller and a proportion automatic regulating valve, wherein the gas flow sensor and the proportion automatic regulating valve are arranged on a traction breaking air inlet pipe 342, the gas flow sensor and the proportion automatic regulating valve are both connected with the flow controller, the flow controller is connected with a micro-liquid bead particle size model prediction controller, and the gas flow sensor detects the air inlet flow of the traction breaking air inlet pipe 342 in real time and transmits the air inlet flow to the flow controller; the microbead particle size model predictive controller sends a gas inlet flow set value control instruction to the flow controller, and the flow controller controls the opening of the proportional automatic regulating valve according to the deviation of the gas inlet flow set value and the real-time detection data, so as to regulate the particle size of the microbeads.
The online real-time control method for the particle size of the micro-liquid beads in the first embodiment of the invention comprises the following steps:
S1, determining a particle size index of a granulating liquid microbead according to process requirements, calculating an optimal traction stretch-break air inlet pipe 342 air inlet flow velocity v required by meeting the particle size index of the granulating liquid microbead by a microbead size prediction model controller according to a formula (1), sending an optimal air inlet flow set value instruction to a flow controller, and automatically updating a flow set value of the flow controller;
s2, an air flow sensor detects the air inlet flow of the traction breaking air inlet pipe on line in real time, an electric signal of real-time air inlet flow detection is transmitted to a flow controller, and the flow controller controls the opening of a proportional automatic regulating valve according to the deviation of an air inlet flow set value and real-time detection data, so that the constant control of the air inlet flow velocity of the traction breaking air inlet pipe 342 is realized, and the online real-time regulation and control of the particle size of the micro-liquid beads of the granulating liquid is realized.
The second embodiment of the invention is a western medicine variable combination continuous twin-screw wet granulation system which is basically the same as the first embodiment, and is different in that western medicine granulation liquid is sprayed into the inner cavity of the variable combination housing assembly 2 by adopting the existing granulation liquid mixing and spraying device.
According to the embodiment of the invention, the variable combination shell component 1 and the variable combination screw component 2 are arranged, so that the optimized combination function of different western medicine granulation processes is realized, the multifunctional combined type granulating machine can be multipurpose, the market demand of personalized flexible manufacturing with multiple varieties and few batches is met, and the practicability of the second embodiment of the invention is greatly improved.
The foregoing is merely a preferred embodiment of the present invention, and it should be noted that modifications and substitutions can be made by those skilled in the art without departing from the technical principles of the present invention, and these modifications and substitutions should also be considered as being within the scope of the present invention.
Claims (18)
1. A variable combination continuous twin-screw wet granulation system is used for wet granulation of traditional Chinese medicine high-viscosity extract granulation liquid and wet granulation of western medicine granulation liquid, and is characterized in that: the device comprises a granulating controller, a granulating device, and a micro-liquid bead forming and injecting device for high-viscosity granulating liquid of traditional Chinese medicine extract or a granulating liquid mixing and injecting device for western medicines;
the granulating device comprises a variable combination shell assembly and a variable combination screw assembly;
the variable combination shell assembly consists of a plurality of detachable modules, is convenient to detach, clean and optimize and combine in length, and comprises an upper shell, a lower shell and a length adjusting module, wherein the upper shell and the lower shell are surrounded to form a cuboid shell, the length adjusting module is arranged on the right side of the shell, and the length of the inner cavity of the variable combination shell assembly is adapted to the length of the variable combination screw assembly by changing the length adjusting modules with different length specifications;
The variable combination screw assembly is provided with two parts, the two parts are arranged in the variable combination housing assembly side by side, the left end of the variable combination screw assembly extends out of the variable combination housing assembly and is respectively connected with two output shafts of a homodromous conjugate meshing reduction gearbox driven by a variable frequency driving motor through a coupler, and the two variable combination screw assemblies are subjected to homodromous conjugate meshing rotation in the housing under the rotary driving of the variable frequency driving motor;
the variable combination screw assembly comprises a precompression unit arranged on the left side and a variable combination granulating unit arranged on the right side;
the precompression unit comprises a constant-pitch frustum screw rod, the constant-pitch frustum screw rod comprises a cylindrical section, a frustum screw rod section, a straight screw rod section and a hexagonal prism shaft section which are sequentially connected from left to right, the screw pitch of the frustum screw rod section is unchanged and equal to that of the straight screw rod section, the root diameter of the frustum screw rod section is a taper which gradually increases from left to right, the thread outer diameter of the frustum screw rod section is a taper which gradually decreases from left to right, and the thread depth of the frustum screw rod section is gradually decreased from left to right, so that raw material powder can be precompressed; the root diameter of the straight screw rod section is consistent with the root diameter of the right end of the frustum screw rod section, and the thread outer diameter of the straight screw rod section is consistent with the thread outer diameter of the right end of the frustum screw rod section;
The variable combination granulating unit is sleeved on the outer side surface of the hexagonal prism shaft section and comprises a first KE granulating module group, a first conveying screw module, a second KE granulating module group, a second conveying screw module, a third KE granulating module group and a supporting shaft sleeve which are sequentially connected from left to right, wherein the first KE granulating module group and the second KE granulating module group are respectively provided with a plurality of KE granulating modules, the first KE granulating module group and the second KE granulating module group can be used for optimally combining the disc numbers of the KE granulating modules according to different granulating processes, the appearance of the KE granulating modules is a fusiform with spiral propelling curved surfaces on the side surfaces, the screw pitches and the lengths of the first conveying screw module and the second conveying screw module can be optimally combined according to different granulating processes, and a thrust bolt is arranged on the right end surface of the hexagonal prism shaft section and can be used for axially positioning and fastening all parts of the variable combination screw assembly;
the left end of the upper side wall of the upper shell is provided with a feed inlet for feeding multicomponent raw material powder, and the left side of the upper side wall of the upper shell, which is arranged on the first KE granulating module group, is provided with a liquid inlet for granulating liquid; the micro-liquid bead forming and injection device is in sealing connection with a liquid outlet and a liquid inlet, or a granulating liquid injection nozzle of the granulating liquid mixing and injection device is in sealing connection with the liquid inlet;
The variable-frequency driving motor, the micro-liquid bead forming and injecting device or the granulating liquid mixing and injecting device are connected with the granulating controller.
2. A variable combination continuous twin screw wet granulation system as defined in claim 1, wherein: the novel variable combination granulating device is characterized in that an infinite-shaped inner cavity formed by intersecting a front circular arc inner cavity and a rear circular arc inner cavity is formed in the middle of the inside of the shell, two variable combination screw components are coaxial with the two circular arc inner cavities of the infinite-shaped inner cavity respectively, the left side of the infinite-shaped inner cavity is a conical precompression chamber consistent with the conical outer diameter of a conical thread of a conical screw section, the right side of the infinite-shaped inner cavity is a straight-through shape matched with the outer diameter of the thread of a straight screw section, and a granulating chamber is formed at the corresponding part of the infinite-shaped inner cavity and the variable combination granulating unit.
3. A variable combination continuous twin screw wet granulation system as defined in claim 2, wherein: gaps of 0.2-0.4 mm are reserved between the thread outer diameter of the constant pitch frustum screw and the corresponding inner side wall of the + -shaped inner cavity; the clearance between the thread outer diameter of one variable combination screw assembly and the corresponding root diameter of the other variable combination screw assembly in the two variable combination screw assemblies which are meshed in the same direction in a conjugate way is set to be 0.2-0.4 mm.
4. A variable combination continuous twin screw wet granulation system as defined in claim 1, wherein: the volume compression ratio of the first screw pitch of the large end and the first screw pitch of the small end of the external thread of the screw section of the frustum is 1.5-2.5: 1.
5. a variable combination continuous twin screw wet granulation system as defined in claim 1, wherein: the center of each KE granulating module is provided with a hexagonal through hole matched with the appearance of the hexagonal prism shaft section, and every two adjacent KE granulating modules in the first KE granulating module group and the second KE granulating module group are radially staggered by 60 degrees;
the root diameter and the thread outer diameter of the first conveying screw module and the second conveying screw module are consistent with those of the straight screw section, and hexagonal through holes matched with the shapes of the hexagonal prism shaft sections are formed in the centers of the first conveying screw module and the second conveying screw module;
and a hexagonal through hole matched with the hexagonal prism shaft section is formed in the support shaft sleeve.
6. A variable combination continuous twin screw wet granulation system as defined in claim 1, wherein: the variable combination screw assembly further comprises a rotary impeller, the rotary impeller is fixedly connected to the outer side face of the cylindrical section, four spiral propelling curved surface blades are uniformly distributed on the outer side face of the rotary impeller in a circumferential mode, the four spiral propelling curved surface blades of the rotary impeller on the two variable combination screw assemblies form homodromous conjugate meshing rotary fit, and the rotary impeller is used for carrying out pre-stirring and rapid dispersion mixing effects on multi-component raw material powder entering the shell, and meanwhile propelling the raw material powder to move forwards.
7. A variable combination continuous twin screw wet granulation system as defined in claim 1, wherein: four rectangular open grooves uniformly distributed in circumference are arranged on the internal and external threads of the frustum screw section, which are 25-33% of the length range of the frustum screw section, of the constant-pitch frustum screw and are used for carrying out rotary stirring dispersion fluidization on the multi-component raw material powder entering the inner cavity of the shell.
8. A variable combination continuous twin screw wet granulation system as defined in claim 1, wherein: the variable combined shell assembly further comprises a left bearing box, a discharging module, a right bearing box and a bearing end cover;
the left bearing box is connected with the left end head of the shell in a sealing way and is used for supporting the left shaft end of the variable combination screw assembly;
the discharging module is connected to the right side of the length adjusting module in a sealing way, a discharging hole is formed in the lower end of the discharging module and used for discharging end product particles, the right bearing box is connected to the right side of the discharging module in a sealing way and used for supporting a right end supporting shaft sleeve of the variable combination screw assembly, and the bearing end cover is connected to the right side of the right bearing box in a sealing way;
two locking screws are respectively arranged on the front side and the rear side of the right end face of the upper shell and the right end face of the lower shell, the four locking screws are uniformly distributed in an array, the locking screws sequentially penetrate through the length adjusting module, the discharging module, the right bearing box and the bearing end cover, the end parts are locked and fixed through locking nuts, and the variable combination shell components are fixedly connected in a sealing mode;
The supporting shaft sleeve sequentially penetrates through the discharging module, the right bearing box and the bearing end cover from left to right.
9. A variable combination continuous twin screw wet granulation system as defined in claim 8, wherein: the left bearing box is in a kidney-shaped shape with a step at the right end, a step kidney-shaped hole matched with the shape of the left bearing box is formed in the left side of the infinity-shaped inner cavity in the shell, the left bearing box is clamped in the step kidney-shaped hole, and the rotary impeller is arranged on the right side of the left bearing box;
the left end is equipped with the first infinity shape through-hole coaxial with the infinity shape inner chamber in the left bearing box, dislocation in the both sides circular arc hole of first infinity shape through-hole is provided with the antifriction bearing that corresponds the cylinder section cooperation fastening with two changeable combination screw rod subassemblies, the cylinder section excircle is fastened with this antifriction bearing inner circle, the right-hand member is equipped with two respectively with corresponding cylinder section excircle matched with first round hole in the left bearing box, first round hole and first infinity shape through-hole correspond side circular arc hole coaxial and be linked together.
10. A variable combination continuous twin screw wet granulation system as defined in claim 8, wherein: the left side of the length adjusting module is provided with a first rectangular boss matched with the first rectangular groove, the right side of the length adjusting module is provided with a second rectangular groove, the left side of the discharging module is provided with a second rectangular boss matched with the second rectangular groove, the first rectangular boss is clamped in the first rectangular groove, and the second rectangular boss is clamped in the second rectangular groove, so that the upper shell, the lower shell, the length adjusting module and the discharging module are in sealing connection;
The length adjusting module is provided with a second infinity-shaped through hole coaxial with the infinity-shaped inner cavity of the shell, the inner diameter of the second infinity-shaped through hole is consistent with the inner diameter of the right end of the infinity-shaped inner cavity, and the length adjusting module is used for prolonging the length of the infinity-shaped inner cavity of the shell after the variable combination screw assembly is lengthened due to the change of the granulating process, so that a variable combination granulating unit can partially enter the second infinity-shaped through hole, the length adjustment of the inner cavity of the shell is realized, and the variable combination screw assembly is suitable for the optimized combination of different granulating processes;
and a third infinity-shaped through hole coaxial with the circular arc-shaped inner cavities at two sides of the infinity-shaped inner cavity is arranged in the middle of the discharging module, and the discharging port is communicated with the third infinity-shaped through hole.
11. A variable combination continuous twin screw wet granulation system as defined in claim 8, wherein: the right side of the discharging module is provided with a first infinity-shaped reaming coaxial with the third infinity-shaped through hole, the left side of the right bearing box is provided with a infinity-shaped stepped boss matched with the third infinity-shaped through hole and the first infinity-shaped reaming, and the infinity-shaped stepped boss is inserted into the third infinity-shaped through hole and the first infinity-shaped reaming to enable the right bearing box to be in sealing connection with the discharging module;
the two sides in the ≡shaped stepped boss are respectively provided with a second round hole matched with the outer diameter of the supporting shaft sleeve, the right side of the right bearing box is provided with a second ≡shaped reaming coaxial with the ≡shaped stepped boss, the second ≡shaped reaming is communicated with the second round holes on the two sides, rolling bearings matched and fastened with the outer circular surfaces of the supporting shaft sleeve corresponding to the two variable combination screw components are arranged in the circular arc holes on the two sides of the second ≡shaped reaming in a staggered manner, and the outer circular surfaces of the supporting shaft sleeve are fastened with the inner ring of the rolling bearing;
The bearing end cover is characterized in that an infinity-shaped boss coaxial with the infinity-shaped inner cavity is arranged on the left side surface of the bearing end cover, the infinity-shaped boss is inserted into the infinity-shaped reamer hole of the second infinity-shaped reamer hole and fixedly connected with the right bearing box in a sealing way, third round holes matched with the outer circle of the supporting shaft sleeve are formed in two sides of the infinity-shaped boss, and the supporting shaft sleeve extends out of the third round holes, so that the free expansion and contraction of the variable combined screw assembly due to the length change of the optimized combination of different granulating processes and the flexible change of the axial installation position of the bearing at the right end are realized.
12. A variable combination continuous twin screw wet granulation system as defined in claim 8, wherein: the length adjusting module, the discharging module, the right bearing box and the bearing end cover are all provided with U-shaped open slots matched with locking screws at the right end of the upper shell, two locking screws at the right end of the upper shell penetrate through the U-shaped open slots to lock the variable combination shell assembly, and the U-shaped open slots enable the upper shell to be quickly installed, detached and cleaned in an inner cavity.
13. A variable combination continuous twin screw wet granulation system according to any of claims 1 to 12, wherein: the microbead forming and injecting device comprises a high-frequency pulse air inlet system, a granulating liquid conveying tank, a suspension conveying pipe, a microbead manufacturing pipe, a microbead injection pipe and a microbead particle size control system;
The high-frequency pulse air inlet system is connected with the granulating controller;
the granulating liquid conveying tank comprises an upper cover, a cylinder body and a lower cover which are sequentially connected from top to bottom, a high-frequency air inlet is inserted in the middle of the upper cover, and the high-frequency pulse air inlet system is in sealing connection with the high-frequency air inlet and is used for continuously conveying granulating liquid with high viscosity of the traditional Chinese medicine extract in the tank downwards in a high-frequency pulse manner; the device comprises a cylinder body, and is characterized in that an annular groove is formed in the lower end face of the cylinder body, a cylindrical boss is arranged in the middle of the bottom face of the annular groove, the height of the boss is smaller than the depth of the annular groove, a cylindrical pit is formed in the inner surface of the bottom of the cylinder body, a horn-shaped circular arc chamfer is formed at a pit opening, a hemispherical pit is formed in the middle of the bottom of the pit, a nipple is inserted in the middle of the hemispherical pit, a lower cover is arranged on the lower end face of the cylinder body, a gap of 0.2-0.5mm is reserved between the upper end face of the lower cover and the lower end face of the cylindrical boss, a suspension conveying pipe is inserted in the middle of the lower cover, the lower end of the nipple is inserted in the suspension conveying pipe, an annular gap is reserved between the outer side wall of the nipple and the inner side wall of the suspension conveying pipe, a first air inlet is formed in the outer side wall of the lower end of the cylinder body, the first air inlet is communicated with the annular groove, a suspension air cushion is arranged at the outer end of the first air inlet and is communicated with a compressed air inlet system, compressed air is used for inputting the compressed air into the annular groove, the annular gap forms an extremely short annular air flow passage, and forms a layer of air cushion in the annular flow passage in the conveying pipe, a layer, high-frequency pulse is conveyed to the suspension pipe, and an adhesive suspension is coated on the inner side of the suspension, and an adhesive suspension is coated on the suspension, and the suspension is prevented from being granulated;
The device comprises a micro-bead manufacturing tube, a micro-bead injection tube, a suspension conveying tube, a compression air inlet system, a suspension conveying tube, a compression air inlet system and a granulating liquid micro-bead injection tube, wherein the upper end of the micro-bead manufacturing tube is provided with an opening, an outwards extending flange is arranged on the outer side surface of the upper end, the upper end surface of the flange is fixedly connected with the lower end surface of the lower cover in a sealing manner, the micro-bead injection tube is inserted in the middle of the lower bottom wall of the micro-bead manufacturing tube in a sealing manner, the lower end opening of the micro-bead injection tube is provided with a horn-shaped outlet, the suspension conveying tube is sleeved in the micro-bead manufacturing tube, a narrow gap of 0.2-0.5mm is reserved between the lower end surface of the micro-bead injection tube and the upper end surface of the micro-bead injection tube, a traction breaking air inlet tube is arranged on the outer side wall of the upper end of the micro-bead manufacturing tube, the traction breaking air inlet tube is communicated with the interior of the micro-bead manufacturing tube, the outer end of the traction breaking air inlet system is communicated with the compressed air inlet system, and is used for inputting compressed air into the micro-bead manufacturing tube, the compression air is used for forming extremely short high-speed impact air flow at the narrow gap in the narrow gap, and continuously pulsing and breaking granulating liquid output from the suspension conveying tube, so that a necking granulating liquid is in the micro-bead injection tube, a small in the granulating hole, and a small particle size, and a particle.
14. A method for forming and injecting micro-liquid beads is characterized in that: the method for forming and injecting the microbeads is a method for forming and injecting the microbeads by using the device for forming and injecting the microbeads in the granulating system as claimed in claim 13, and comprises the following steps:
(1) Firstly, compressed gas entering from a suspension air cushion air inlet pipe flows through an annular gap to form an annular suspension air cushion layer in a suspension conveying pipe; then under the drive of high-frequency circulating pulse pressure difference of a high-frequency pulse air inlet system, granulating liquid with high viscosity of the traditional Chinese medicine extract in a granulating liquid conveying tank sequentially passes through a hemispherical pit and a nipple, and flows into a suspension conveying pipe to form air cushion suspension conveying under the condition of wrapping an annular suspension air cushion layer;
(2) The granulating liquid conveyed by air cushion suspension flows out of the suspension conveying pipe and flows into the micro-droplet injection pipe through a narrow gap, when the traction breaking gas entering from the traction breaking air inlet pipe enters into the narrow gap, the traction breaking gas is induced to accelerate rapidly due to sudden shrinkage of the cross section of the flow passage, and local air flow high-speed impact is necessarily formed on the granulating liquid column flowing out of the suspension conveying pipe, so that the granulating liquid column flowing through the narrow gap is locally necked;
(3) The high-speed impact air flow flowing through the narrow gap flows into the micro-droplet injection tube, and forms annular air flow wrapping the granulating liquid column with local necking, and as the air flow speed is far greater than the flow speed of the wrapped granulating liquid column, the wrapped granulating liquid column is formed to have traction and stretching effects, so that the wrapped granulating liquid column is pulled and broken by necking at the necking position, and finally the granulating liquid micro-droplet is formed at the horn-shaped outlet;
(4) The granulating liquid microbeads formed in the step (3) are sprayed out from a trumpet-shaped outlet of a microbead injection tube, flow into an + -shaped inner cavity of the shell from a liquid inlet on the upper shell, are coupled through periodic high-frequency pulse transmission, so that continuous manufacturing of the granulating liquid microbeads with high viscosity of the traditional Chinese medicine extract is realized, and the granulating liquid microbeads are continuously output from the trumpet-shaped outlet and are continuously and quantitatively conveyed to a granulating chamber of the shell.
15. A microbead particle size control system for online real-time control of microbead particle size of continuous quantitative output of a microbead forming and injecting device in a granulating system as claimed in claim 13, characterized in that: comprises a micro-droplet particle size prediction model controller and a traction breaking air inlet pipe air inlet flow rate control unit.
16. The microbead particle size control system of claim 15, wherein: the microbead particle size prediction model controller is constructed based on a gas inlet flow rate cooperative coupling association control prediction model of a microbead particle size and a traction stretch-break gas inlet pipe, and the association control prediction model of the prediction model controller has a calculation formula as follows:
（1）
wherein d is the particle size of the liquid microsphere of the granulating liquid; v is the flow velocity of the gas inlet at the position of the traction breaking gas inlet pipe, and e is a natural constant;
Based on the associated control prediction model calculation formula (1), programming the embedded programming of the micro-droplet particle size model prediction controller on a granulating controller host, so that the micro-droplet particle size model prediction controller can realize the online real-time regulation and control of the particle size of the granulating liquid micro-droplet of the traditional Chinese medicine high-viscosity extractum by adjusting the gas inlet flow rate of the traction stretch-break air inlet pipe.
17. The microbead particle size control system of claim 16, wherein: the flow rate control unit of the gas inlet of the traction breaking inlet pipe comprises a gas flow sensor, a flow controller and a proportion automatic regulating valve, wherein the gas flow sensor and the proportion automatic regulating valve are arranged on the traction breaking inlet connecting pipe, the gas flow sensor and the proportion automatic regulating valve are both connected with the flow controller, the flow controller is connected with the micro-droplet particle size model prediction controller, and the gas flow sensor detects the inlet flow of the traction breaking inlet connecting pipe in real time and transmits the inlet flow to the flow controller; the micro-droplet particle size model predictive controller sends a gas inlet flow set value control instruction to the flow controller, and the flow controller controls the opening of the proportional automatic regulating valve according to the deviation of the gas inlet flow set value and the real-time detection data, so as to realize the constant control of the inlet flow velocity of the traction stretch-break air inlet connecting pipe.
18. The microbead particle size control system of claim 17, wherein: the granulating liquid microbead particle size online real-time control method of the microbead particle size control system comprises the following steps:
s1, determining a particle size index of a granulating liquid microbead according to process requirements, calculating an optimal traction stretch-breaking air inlet pipe gas inlet flow velocity v required by meeting the particle size index of the granulating liquid microbead according to a formula (1) by a microbead size prediction model controller, sending an optimal gas inlet flow set value instruction to a flow controller, and automatically updating a flow set value of the flow controller;
s2, an air flow sensor detects the air inlet flow of the traction breaking air inlet pipe on line in real time, an electric signal of real-time air inlet flow detection is transmitted to a flow controller, and the flow controller controls the opening of a proportional automatic control valve according to the deviation of an air inlet flow set value and real-time detection data, so that the constant control of the inlet flow velocity of the traction breaking air inlet pipe is realized, and the on-line real-time regulation and control of the particle size of the micro-liquid beads of the granulating liquid is realized.
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