CN1175926C - Conjugate linoleate microcapsule - Google Patents
Conjugate linoleate microcapsule Download PDFInfo
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- CN1175926C CN1175926C CNB011376597A CN01137659A CN1175926C CN 1175926 C CN1175926 C CN 1175926C CN B011376597 A CNB011376597 A CN B011376597A CN 01137659 A CN01137659 A CN 01137659A CN 1175926 C CN1175926 C CN 1175926C
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- microcapsules
- linoleate
- conjugate linoleate
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Abstract
The present invention relates to a microcapsule made from conjugated linoleic acid salt, which is prepared from conjugated linoleic acid salt, other fatty acid salt, a wall material, a solvent and an antioxidant. The mixed fatty acid salt powder with conjugated linoleic acid is suspended on a fluidized bed, and the wall material is dissolved in the solvent, enters the fluidized bed in a spraying way, and then is dried to obtain a microcapsule product. A great number of experiments prove that the product has the advantages of great enhancement of antioxidant stability and easy use, and moreover, the abnormal smell of the product can be masked, the release of the product can be controlled, and the shelf life of the product is efficiency enhanced.
Description
Technical field
The present invention relates to a kind of microcapsules that adopt fluid bed to prepare conjugate linoleate
Background technology
Microcapsules technology (microencapsulation) is a current new technology that develops rapidly, be meant with wall material (coating) material food composition or food additives embeddings such as the capsule heart (core) material such as grease, spices, flavouring, make it isolated, discharge again in due course with external environment.
Up to now, the method for microencapsulation can be divided into three major types: 1, the applied chemistry principle prepares the method for microcapsules, as interfacial polymerization, situ aggregation method etc.; 2, the Applied Physics principles of chemistry prepare the method for microcapsules, as single coacervation, complex coacervation, oil-phase separating method etc.; 3, Applied Physics and theory of mechanics prepare the method for microcapsules, as pot bag method, spray-on process, porous centrifugal process etc.
CLA (Conjugated Linoleic Acid) is the mixture that contains a series of octadecadienoic acids of conjugated double bond.CLA is paid close attention to by increasing scientific research both at home and abroad and medical institutions with the health care of its excellence, disease-resistant function, and competitively develops the product at food, medicine and feed industry.
According to data from abroad report CLA many functions are arranged, as:
U.S. Pat 5554646,5814663 and PCT WO 97/46230 report CLA can be induced the energy utilization and be caused body weight to descend, and do not store fat.
U.S. Pat 5428072 reports can promote effective absorption of food.
After U.S. Pat 5919767 report sportsmen are edible, can slow down metabolism, strengthen endurance.
U.S. Pat 5430066,5585400,6214372,5814210 reports can relax as immunoreactive negative interactions such as apocleisis, protein decomposition; And having anti-sudden change, the protection humans and animals is avoided the effects such as injury of a series of cancers; Simultaneously can change the bone abnormal state, keep even increase the bone content of mineral substances.
European patent EP 779033 A1 report CLA also can improve human some physiological status, as improving the level of vitamin A in the body, reduces body inner cholesterol, LDL cholesterol, HDL cholesterol level.
Because the less stable of CLA can be prepared into it and not lose bioactive various salt, to improve stability; Handle if carry out microencapsulation again, can prolong the shelf life of conjugate linoleate greatly.
In many prior arts, do not see the report of the microencapsulation that conjugate linoleate is arranged both at home and abroad as yet.The present invention adopts fluid bed to make microcapsule product conjugate linoleate.
The fatty acid mixed that the preparation of conjugate linoleate can be by will containing CLA and the metal oxide of equivalent or metal hydroxides are kept pH value 8-9 in the presence of water, 60-90 ℃ of reaction after 1 hour drying can obtain.
Summary of the invention
The object of the invention is that the microcapsules of the conjugate linoleate developed are made up of conjugate linoleate, other soaps, wall material, solvent, antioxidant, the powder suspension of mixing-in fat hydrochlorate that will contain CLA is on fluid bed, the mode that again the wall material is dissolved in the solvent with spraying enters fluid bed, carries out drying again and can obtain microcapsule product; This product has the following advantages through a large amount of experimental results show that:
1, strengthens its antioxygenic property, make it avoid the interference of extraneous undesirable element, improve bin stability at lay up period.
2, can shelter smell, stink.
3, can avoid mismatching in many components prescription the influencing each other of 5 components reduced the generation of bad change reaction.
4, can reach the purpose that control discharges.
5, be made into dry pressed powder, be easier to store, transport and add.
The microcapsules of the conjugate linoleate that the present invention developed can be used for health nutrient, food additives, functional feedstuff additive, anticorrisive agent, anti-go mouldy agent and medicine and other fields.
The microcapsules of conjugate linoleate of the present invention, these microcapsules are made up of conjugate linoleate, other soaps, wall material, solvent, antioxidant, the powder suspension of mixing-in fat hydrochlorate that will contain CLA is on fluid bed, the mode that again the wall material is dissolved in the solvent with spraying enters fluid bed, carries out drying again and can obtain microcapsule product; Wherein each set of dispense ratio is:
100 grams contain conjugate linoleate 30-95%, other soap 5-70%;
Wall material 8-20 gram
Solvent 10-30 gram
Antioxidant 0-0.5 gram.
The preparation method of the microcapsules of conjugate linoleate follows these steps to carry out:
A, at first 100 grams are contained the powder suspension of mixing-in fat hydrochlorate of conjugate linoleate and other soap on fluid bed;
B, the mode that the wall material is dissolved in the solvent with spraying enter fluid bed, spray time 10-20 minute;
C, at 60-100 ℃ of following drying and forming-film, form the microcapsules of the mixing-in fat hydrochlorate contain conjugate linoleate.
Conjugate linoleate is potassium, soda slaine or calcium, magnesium, zinc slaine; Other soap is myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture.
The wall material can be natural filmogen, as natural plant gum or gelatin or gum arabic or sodium alginate or shellac or polysaccharide compound or linseed glue; Also can be product, as methylcellulose or ethyl cellulose or carboxymethyl cellulose or cellulose acetate butyrate ester or cellulose acetate-phthalate ester or hydroxyethylcellulose or hydroxypropyl cellulose or hydroxypropyl methylcellulose or Hydroxypropyl Methylcellulose Phathalate ester through chemical modification; Can also be the synthetic high polymer filmogen, as polyvinyl alcohol or methyl methacrylate or polyvinyl chloride or polyvinylidene chloride; This wall material in use can be a kind of, also can be the mixture of several wall materials.
Antioxidant is various isomers or ditert-butylhydro quinone or butylated hydroxyarisol or Yoshinox BHT or the multiple agent of propyl gallate/ascorbyl palmitate or the multiple agent of citric acid/sodium citrate or lecithin or the rosemary extract of Vitamin C or the vitamin e α, the β that comprise VE, γ, δ, ε, η.
Solvent is acetone or absolute ethyl alcohol or ethyl acetate or absolute methanol or anhydrous isopropyl alcohol.
These microcapsules are used for health nutrient or food additives or functional feedstuff additive or anticorrisive agent or anti-go mouldy agent or drug world.
The specific embodiment
Embodiment 1
A, at first 100 grams are contained the mixing-in fat acid sodium-salt powder suspension of CLA sodium salt 30%, other fatty acid sodium salt (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 70% on fluid bed;
B, wall material methylcellulose 8 gram is dissolved in the mode with spraying enters fluid bed, spray time 10 minutes in the 15 gram acetone solvents;
C, at 60 ℃ of following drying and forming-films, form the microcapsules of the mixing-in fat acid sodium-salt contain the CLA sodium salt.These microcapsules contain CLA sodium salt 28%, methylcellulose 7%, other fatty acid sodium salt 65%.
Embodiment 2
A, at first 100 grams are contained the mixing-in fat acid potassium salt powder suspension of CLA sylvite 50%, other aliphatic acid sylvite (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 50% on fluid bed;
B, wall material ethyl cellulose 10 gram is dissolved in the mode with spraying enters fluid bed, spray time 15 minutes in the 15 gram anhydrous ethanol solvents;
C, at 70 ℃ of following drying and forming-films, form the microcapsules of the mixing-in fat acid potassium salt contain CLA sylvite.These microcapsules contain CLA sylvite 45.5%, ethyl cellulose 9%, other aliphatic acid sylvite 45.5%.
Embodiment 3
A, at first 100 grams are contained the mixing-in fat acid calcium salt powder suspension of calcium salt of conjugated linolic acid 70%, other fatty acid calcium salt (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 30% on fluid bed;
B, wall material gum arabic 15 gram is dissolved in the mode with spraying enters fluid bed, spray time 20 minutes in the 20 gram absolute methanol solvents;
C, at 80 ℃ of following drying and forming-films, form the microcapsules of the mixing-in fat acid calcium salt contain calcium salt of conjugated linolic acid.These microcapsules contain calcium salt of conjugated linolic acid 61%, gum arabic 13%, other fatty acid calcium salt 26%.
Embodiment 4
A, at first 100 grams are contained the fatty acid mixed zinc salt powder suspension of zinc conjugated linoleate 65%, other fatty acid zinc salt (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 35% on fluid bed;
B, wall material gelatin 17 gram is dissolved in the mode with spraying enters fluid bed, spray time 20 minutes in the 30 gram ethyl acetate solvents;
C, at 80 ℃ of following drying and forming-films, form the microcapsules of the fatty acid mixed zinc salt contain zinc conjugated linoleate.These microcapsules contain zinc conjugated linoleate 56%, gelatin 14%, other fatty acid zinc salt 30%.
Embodiment 5
A, at first 100 grams are contained the fatty acid mixed magnesium salts powder suspension of CLA magnesium salts 90%, other fatty acid magnesium salt (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 10% on fluid bed;
B, wall material ethyl cellulose 8 gram and carboxymethyl cellulose 10 grams are mixed be dissolved in that the mode with spraying enters fluid bed, spray time 18 minutes in the 20 gram anhydrous isopropyl alcohol solvents;
C, at 95 ℃ of following drying and forming-films, form the microcapsules of the fatty acid mixed magnesium salts contain the CLA magnesium salts.These microcapsules contain CLA magnesium salts 76%, ethyl cellulose and cmc blend 8.5%, other fatty acid magnesium salt 15.5%.
Embodiment 6
A, at first 100 grams are contained the mixing-in fat acid potassium salt, antioxidant Vitamin C 0.1 gram powder suspension of CLA sylvite 95%, other aliphatic acid sylvite (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 5% on fluid bed;
B, wall material cellulose acetate phthalate ester 6 gram and hydroxyethylcellulose 6 grams are mixed be dissolved in that the mode with spraying enters fluid bed, spray time 15 minutes in the 30 gram anhydrous ethanol solvents;
C, at 100 ℃ of following drying and forming-films, form the microcapsules of the mixing-in fat acid potassium salt contain CLA sylvite.These microcapsules contain CLA sylvite 85%, cellulose acetate phthalate ester and hydroxyethylcellulose mixture 4.5%, other aliphatic acid sylvite 10.5%.
Embodiment 7
A, at first 100 grams are contained the mixing-in fat acid sodium-salt, antioxidant vitamin e 0.05 gram powder suspension of CLA sodium salt 75%, other fatty acid sodium salt (myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 25% on fluid bed;
B, wall material polyvinyl alcohol 16 gram is dissolved in the mode with spraying enters fluid bed, spray time 15 minutes in the 20 gram absolute methanol solvents;
C, at 85 ℃ of following drying and forming-films, form the microcapsules of the mixing-in fat acid sodium-salt contain the CLA sodium salt.These microcapsules contain CLA sodium salt 65%, cellulose acetate phthalate ester and hydroxyethylcellulose mixture 13%, other fatty acid sodium salt 22%.
Embodiment 8
A, at first 100 grams are contained the fatty acid mixed zinc salt, antioxidant ditert-butylhydro quinone 0.2 gram powder suspension of zinc conjugated linoleate 45%, other fatty acid zinc salt (myristate stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture) 55% on fluid bed;
B, wall material methyl methacrylate 15 gram is dissolved in the mode with spraying enters fluid bed, spray time 15 minutes in the 10 gram ethyl acetate solvents;
C, at 65 ℃ of following drying and forming-films, form the microcapsules of the fatty acid mixed zinc salt contain zinc conjugated linoleate.These microcapsules contain zinc conjugated linoleate 39%, methyl methacrylate 13%, other fatty acid zinc salt 48%.
Claims (8)
1, a kind of microcapsules of conjugate linoleate, it is characterized in that these microcapsules are made up of conjugate linoleate, other soap, wall material, solvent, antioxidant, the powder suspension of mixing-in fat hydrochlorate that will contain CLA is on fluid bed, the mode that again the wall material is dissolved in the solvent with spraying enters fluid bed, carries out drying again and can obtain microcapsule product; Wherein each set of dispense ratio is:
100 grams contain conjugate linoleate 30-95%, other soap 5-70%;
Wall material 8-20 gram
Solvent 10-30 gram
Antioxidant 0-0.5 gram.
2, the preparation method of the microcapsules of conjugate linoleate according to claim 1 is characterized in that following these steps to carrying out:
A, at first 100 grams are contained the powder suspension of the mixing-in fat hydrochlorate of conjugate linoleate and other soap and antioxidant on fluid bed;
B, the mode that the wall material is dissolved in the solvent with spraying enter fluid bed, spray time 10-20 minute;
C, at 60-100 ℃ of following drying and forming-film, form the microcapsules of the mixing-in fat hydrochlorate contain conjugate linoleate.
3, the microcapsules of conjugate linoleate according to claim 1 is characterized in that conjugate linoleate is potassium, soda slaine or calcium, magnesium, zinc slaine.
4, the microcapsules of conjugate linoleate according to claim 1 is characterized in that other soap is myristate, stearate, palmitate, oleate, linoleate, hexadecene hydrochlorate or above-mentioned two or more mixture.
5, the microcapsules of conjugate linoleate according to claim 1 is characterized in that the wall material can be natural filmogen, as natural plant gum or gelatin or gum arabic or sodium alginate or shellac or polysaccharide compound or linseed glue; Also can be product, as methylcellulose or ethyl cellulose or carboxymethyl cellulose or cellulose acetate butyrate ester or cellulose acetate-phthalate ester or hydroxyethylcellulose or hydroxypropyl cellulose or hydroxypropyl methylcellulose or Hydroxypropyl Methylcellulose Phathalate ester through chemical modification; Can also be the synthetic high polymer filmogen, as polyvinyl alcohol or methyl methacrylate or polyvinyl chloride or polyvinylidene chloride; This wall material in use can be a kind of, also can be the mixture of several wall materials.
6, the microcapsules of conjugate linoleate according to claim 1 is characterized in that solvent is easy dissolving, volatile acetone or absolute ethyl alcohol or ethyl acetate or absolute methanol or anhydrous isopropyl alcohol.
7, the microcapsules of conjugate linoleate according to claim 1 is characterized in that antioxidant is various isomers or ditert-butylhydro quinone or butylated hydroxyarisol or Yoshinox BHT or the multiple agent of propyl gallate/ascorbyl palmitate or the multiple agent of citric acid/sodium citrate or lecithin or the rosemary extract of Vitamin C or the vitamin e α, the β that comprise VE, γ, δ, ε, η.
8, a kind of microcapsules of conjugate linoleate are used to prepare the purposes of health nutrient, food additives, functional feedstuff additive, anticorrisive agent, anti-go mouldy agent or drug world.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011376597A CN1175926C (en) | 2001-10-31 | 2001-10-31 | Conjugate linoleate microcapsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011376597A CN1175926C (en) | 2001-10-31 | 2001-10-31 | Conjugate linoleate microcapsule |
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| CN1357406A CN1357406A (en) | 2002-07-10 |
| CN1175926C true CN1175926C (en) | 2004-11-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011376597A Expired - Fee Related CN1175926C (en) | 2001-10-31 | 2001-10-31 | Conjugate linoleate microcapsule |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD20070049A1 (en) * | 2007-02-14 | 2008-08-15 | Sila S R L | CONJUGATED LINOLEIC ACID PRODUCT AND PROCESS FOR ITS MANUFACTURE |
| CN101559045B (en) * | 2009-05-21 | 2011-05-25 | 阜宁怀仁生物有限公司 | Arachidonic acid nutrition microcapsule with high temperature resistance and preparation method thereof |
| CN101849932B (en) * | 2010-04-15 | 2011-11-16 | 广东海洋大学 | Nutrient preparation of iron and zinc and preparation method thereof |
| CN102550817B (en) * | 2011-12-31 | 2013-11-20 | 厦门金达威集团股份有限公司 | Functional oil microencapsulation and manufacturing method thereof |
| JP6586268B2 (en) * | 2014-10-07 | 2019-10-02 | 辻製油株式会社 | Method for inhibiting heat coloring of lecithin |
| CN107518175A (en) * | 2016-06-29 | 2017-12-29 | 湖南晶天科技实业有限公司 | A kind of feed addictive coating aliphatic acid copper and preparation method thereof and a kind of feed |
| CN106578141A (en) * | 2016-12-20 | 2017-04-26 | 乌鲁木齐上善元生物科技有限公司 | Conjugated linoleic acid microcapsule and preparation method thereof |
| AU2021368862A1 (en) * | 2020-10-30 | 2023-06-08 | Animal Control Technologies (Australia) Pty Ltd | Hygroscopic salt microencapsulation, and uses thereof |
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2001
- 2001-10-31 CN CNB011376597A patent/CN1175926C/en not_active Expired - Fee Related
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