CN117580829A - 作为cd38的抑制剂的喹啉及氮杂喹啉 - Google Patents
作为cd38的抑制剂的喹啉及氮杂喹啉 Download PDFInfo
- Publication number
- CN117580829A CN117580829A CN202280022060.6A CN202280022060A CN117580829A CN 117580829 A CN117580829 A CN 117580829A CN 202280022060 A CN202280022060 A CN 202280022060A CN 117580829 A CN117580829 A CN 117580829A
- Authority
- CN
- China
- Prior art keywords
- alkyl
- amino
- cyclohexyl
- compound
- imidazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163143245P | 2021-01-29 | 2021-01-29 | |
| US63/143,245 | 2021-01-29 | ||
| PCT/US2022/014221 WO2022165114A1 (en) | 2021-01-29 | 2022-01-28 | Quinolines and azaquinolines as inhibitors of cd38 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117580829A true CN117580829A (zh) | 2024-02-20 |
Family
ID=80446310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280022060.6A Pending CN117580829A (zh) | 2021-01-29 | 2022-01-28 | 作为cd38的抑制剂的喹啉及氮杂喹啉 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11952377B2 (https=) |
| EP (2) | EP4674415A3 (https=) |
| JP (2) | JP7777596B2 (https=) |
| KR (1) | KR20230141799A (https=) |
| CN (1) | CN117580829A (https=) |
| AR (1) | AR124718A1 (https=) |
| AU (1) | AU2022212035A1 (https=) |
| BR (1) | BR112023014898A2 (https=) |
| CA (1) | CA3208851A1 (https=) |
| CL (2) | CL2023002163A1 (https=) |
| CO (1) | CO2023009803A2 (https=) |
| CR (1) | CR20230323A (https=) |
| DO (1) | DOP2023000142A (https=) |
| EC (1) | ECSP23056223A (https=) |
| ES (1) | ES3042412T3 (https=) |
| HR (1) | HRP20251111T1 (https=) |
| HU (1) | HUE072981T2 (https=) |
| IL (1) | IL304466A (https=) |
| JO (1) | JOP20230160A1 (https=) |
| MX (1) | MX2023008701A (https=) |
| PE (1) | PE20232047A1 (https=) |
| PL (1) | PL4284511T3 (https=) |
| RS (1) | RS67253B1 (https=) |
| TW (1) | TW202241418A (https=) |
| WO (1) | WO2022165114A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119775288A (zh) * | 2024-12-31 | 2025-04-08 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021021986A1 (en) | 2019-07-31 | 2021-02-04 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of cd38 |
| WO2024217995A1 (en) | 2023-04-20 | 2024-10-24 | Syngenta Crop Protection Ag | Pesticidally active dihydropyridinone derivatives |
| WO2026000074A1 (en) * | 2024-06-25 | 2026-01-02 | Welnx Company Inc. | Use of cd38 inhibitors for reducing th2 inflammation |
| WO2026075971A1 (en) | 2024-10-01 | 2026-04-09 | Neolaia Inc. | Combination therapy for treatment of metabolic disorders and inflamation related disorders using incretin compounds and cd38 inhibitors |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160024096A1 (en) * | 2013-03-14 | 2016-01-28 | Convergene Llc | Methods and compositions for inhibition of bromodomain-containing proteins |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2607064T3 (es) | 2010-12-01 | 2017-03-29 | Glaxosmithkline Llc | Indoles |
| BR112014010803A2 (pt) | 2011-11-04 | 2017-04-25 | Glaxosmithkline Intellectual Property (No 2) Ltd | método de tratamento |
| AU2015356721B2 (en) | 2014-12-03 | 2018-03-15 | Glaxosmithkline Intellectual Property (No.2) Limited | CD38 inhibitors and methods of treatment |
| WO2017053604A1 (en) | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Potent antiviral pyrazolopyridine compounds |
| WO2018151830A1 (en) | 2017-02-17 | 2018-08-23 | Fronthera U.S. Pharmaceuticals Llc | Pyridinyl based apoptosis signal-regulation kinase inhibitors |
| EP3434692A1 (en) | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
| WO2021021986A1 (en) | 2019-07-31 | 2021-02-04 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of cd38 |
| US20230025807A1 (en) | 2019-10-30 | 2023-01-26 | Mitobridge Inc. | Cd38 inhibitors |
| BR112022020291A2 (pt) | 2020-04-07 | 2022-12-06 | Mitobridge Inc | Inibidores de cd38 |
-
2022
- 2022-01-28 HR HRP20251111TT patent/HRP20251111T1/hr unknown
- 2022-01-28 CA CA3208851A patent/CA3208851A1/en active Pending
- 2022-01-28 CR CR20230323A patent/CR20230323A/es unknown
- 2022-01-28 RS RS20250955A patent/RS67253B1/sr unknown
- 2022-01-28 PL PL22704226.4T patent/PL4284511T3/pl unknown
- 2022-01-28 MX MX2023008701A patent/MX2023008701A/es unknown
- 2022-01-28 AR ARP220100173A patent/AR124718A1/es unknown
- 2022-01-28 TW TW111103880A patent/TW202241418A/zh unknown
- 2022-01-28 EP EP25188747.7A patent/EP4674415A3/en active Pending
- 2022-01-28 EP EP22704226.4A patent/EP4284511B1/en active Active
- 2022-01-28 AU AU2022212035A patent/AU2022212035A1/en active Pending
- 2022-01-28 BR BR112023014898A patent/BR112023014898A2/pt unknown
- 2022-01-28 CN CN202280022060.6A patent/CN117580829A/zh active Pending
- 2022-01-28 PE PE2023002190A patent/PE20232047A1/es unknown
- 2022-01-28 KR KR1020237027359A patent/KR20230141799A/ko active Pending
- 2022-01-28 HU HUE22704226A patent/HUE072981T2/hu unknown
- 2022-01-28 ES ES22704226T patent/ES3042412T3/es active Active
- 2022-01-28 JP JP2023544674A patent/JP7777596B2/ja active Active
- 2022-01-28 WO PCT/US2022/014221 patent/WO2022165114A1/en not_active Ceased
- 2022-01-28 US US17/586,939 patent/US11952377B2/en active Active
-
2023
- 2023-07-13 IL IL304466A patent/IL304466A/en unknown
- 2023-07-20 JO JOJO/P/2023/0160A patent/JOP20230160A1/ar unknown
- 2023-07-24 CL CL2023002163A patent/CL2023002163A1/es unknown
- 2023-07-25 DO DO2023000142A patent/DOP2023000142A/es unknown
- 2023-07-25 EC ECSENADI202356223A patent/ECSP23056223A/es unknown
- 2023-07-25 CO CONC2023/0009803A patent/CO2023009803A2/es unknown
-
2024
- 2024-02-28 US US18/590,300 patent/US20240279224A1/en active Pending
- 2024-05-22 CL CL2024001535A patent/CL2024001535A1/es unknown
-
2025
- 2025-06-25 JP JP2025107301A patent/JP2025160175A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160024096A1 (en) * | 2013-03-14 | 2016-01-28 | Convergene Llc | Methods and compositions for inhibition of bromodomain-containing proteins |
Non-Patent Citations (2)
| Title |
|---|
| CURT D: "discovery, synthesis and biological evaluation of thiazoloquin(az)olin(on)es as potent CD38 inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 58, no. 8, 31 December 2015 (2015-12-31), pages 3548 - 3571 * |
| SCULLY STEPHEN S: "synthesis and evaluation of thiazoloquinolinones wiith", ACS MEDICINAL CHEMISTRY LETTERS, vol. 8, no. 2, 31 December 2017 (2017-12-31), pages 196 - 200 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119775288A (zh) * | 2024-12-31 | 2025-04-08 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
| CN119775288B (zh) * | 2024-12-31 | 2025-10-10 | 浙江工业大学 | 一种cd38抑制化合物及应用 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information |
Country or region after: Germany Address after: Ingham, Germany Applicant after: BOEHRINGER INGELHEIM INTERNATIONAL GmbH Address before: German Ingelheim Applicant before: Bollinger Ingelheim International Ltd. Country or region before: Germany |
|
| CB02 | Change of applicant information |