CN117571522B - Vascular stent external loading testing device - Google Patents

Vascular stent external loading testing device Download PDF

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Publication number
CN117571522B
CN117571522B CN202410061641.1A CN202410061641A CN117571522B CN 117571522 B CN117571522 B CN 117571522B CN 202410061641 A CN202410061641 A CN 202410061641A CN 117571522 B CN117571522 B CN 117571522B
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China
Prior art keywords
guide
box body
storage box
vascular stent
connecting rod
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CN117571522A (en
Inventor
刘明远
兰茜
冯海
范振敏
郝祯
张旭
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Beijing Friendship Hospital
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Beijing Friendship Hospital
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N3/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N3/32Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces
    • G01N3/38Investigating strength properties of solid materials by application of mechanical stress by applying repeated or pulsating forces generated by electromagnetic means
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01MTESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M13/00Testing of machine parts
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0001Type of application of the stress
    • G01N2203/0005Repeated or cyclic
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/0014Type of force applied
    • G01N2203/0016Tensile or compressive
    • G01N2203/0019Compressive
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2203/00Investigating strength properties of solid materials by application of mechanical stress
    • G01N2203/003Generation of the force
    • G01N2203/005Electromagnetic means

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Prostheses (AREA)

Abstract

The invention discloses an intravascular stent in-vitro loading testing device, which comprises: a storage box body; further comprises: the guide part is arranged in the storage box body, and a vascular stent is arranged on the guide part; the test part is arranged in the storage box body and positioned at one side of the guide part, and comprises a test sleeve matched with the vascular stent; the connecting rod part is arranged in the storage box body and connected with the guide part, so that the guide part can reciprocate; a driving part which is installed in the storage box body and is connected with the connecting rod part; the driving part drives the connecting rod part to drive the guide part to move, so that the vascular stent reciprocates inside and outside the test sleeve; according to the invention, the vascular stent is installed by designing the guide part, and the guide part is driven by the driving part to move by the connecting rod part, so that the vascular stent reciprocates inside and outside the test sleeve, and further the test work of the vascular stent is completed.

Description

Vascular stent external loading testing device
Technical Field
The invention relates to the field of medical equipment, in particular to an in-vitro loading testing device for a vascular stent.
Background
The vascular stent is an external structure which is formed by placing an inner stent into a lesion section on the basis of the expansion and the formation of a lumen balloon so as to support a narrow occlusion section blood vessel, reduce the elastic retraction and reshaping of the blood vessel and keep the lumen blood flow smooth, and is clinically used for treating atherosclerosis by a method of intervening the vascular stent. Along with the development of the material manufacturing industry and the technical level, the requirements on the vascular stent are more and more, and the treatment method of the interventional vascular stent is quite effective, but the problems of restenosis, thrombus, endothelial hyperplasia and the like in the blood vessel can still occur after operation, and the problems are closely related to the mechanical properties of the vascular stent.
The stent used after the interventional operation needs to be compressed and then unfolded, and still has good radial supporting force to restore the vessel diameter of the lesion position.
Therefore, the compression test of the vascular stent is an important content of the vascular stent before use, and in the prior art, a testing device which has a simple structure and is convenient to operate is not used for testing the compression fatigue resistance of the vascular stent so as to ensure the use safety of the vascular stent.
Disclosure of Invention
The invention aims to: provides an external loading testing device for a vascular stent, which aims to solve the problems in the prior art.
The technical scheme is as follows: an intravascular stent in vitro loading testing device comprising:
a storage box body;
Further comprises:
the guide part is arranged in the storage box body, and a vascular stent is arranged on the guide part;
the test part is arranged in the storage box body and positioned at one side of the guide part, and comprises a test sleeve matched with the vascular stent;
The connecting rod part is arranged in the storage box body and connected with the guide part, so that the guide part can reciprocate;
a driving part which is installed in the storage box body and is connected with the connecting rod part;
the driving part drives the connecting rod part to drive the guide part to move, so that the vascular stent reciprocates inside and outside the test sleeve;
according to the invention, the vascular stent is installed by designing the guide part, and the guide part is driven by the driving part to move by the connecting rod part, so that the vascular stent reciprocates inside and outside the test sleeve, further the test work of the vascular stent is completed, the structure is simple, the operation is convenient, the compression fatigue resistance of the vascular stent is tested, and the use safety of the vascular stent is ensured.
In a further embodiment, the guide comprises:
the guide rail is arranged in the storage box body, and a guide groove is formed in the guide rail;
the guide sliding plate is arranged in the guide groove and is in sliding fit with the guide groove;
the guide support is arranged on the guide sliding plate and has a preset gradient.
In a further embodiment, the vascular stent is disposed on the guide stent.
When the guiding bracket is connected with the blood vessel bracket, the blood vessel bracket can be connected with the guiding bracket by designing a buckle, and the guiding bracket is designed with the buckle and is connected with the blood vessel bracket by the buckle;
the guiding bracket and the vascular bracket can be connected through threads, a thread groove is formed in the guiding bracket, and the vascular bracket and the guiding bracket are connected through bolts or screws;
The guide bracket has a preset gradient, so that the vascular bracket can better enter the test sleeve in a reciprocating manner, and is detachably connected with the vascular bracket, so that the vascular bracket can be better assembled and disassembled.
In a further embodiment, the test sleeve is connected with the storage box body, a chamfer angle with a preset angle is arranged at the end part of the test sleeve, and a movement groove is formed in the bottom part of the test sleeve.
The test sleeve is in order to let the better laminating of vessel support and get into, and inside both ends are equipped with predetermined angle chamfer to in order to guide support realization reciprocating motion, set up the movement groove in test sleeve's bottom.
In a further embodiment, the linkage portion includes:
The swinging parts are provided with two groups which are respectively arranged in the storage box body and are arranged in parallel, and each group comprises a connecting rod seat arranged in the storage box body and a swinging connecting rod hinged with the connecting rod seat;
The two ends of the connecting rod are respectively hinged with the swinging connecting rods in the two groups of swinging pieces;
and the rocker is hinged with any end of the connecting rod.
The two groups of swing connection, the single connecting link and the single rocker form the quick return characteristic of the four-bar mechanism, and the process of quickly entering the test sleeve after the vascular stent is arranged on the guide stent can simulate the doctor to quickly send the vascular stent into the appointed position.
In a further embodiment, the driving part includes:
the motor is arranged in the storage box body;
the crank is connected with the output end of the motor;
And the rocking block is sleeved with the rocking rod and connected with the crank.
By adjusting the rotation speed of the motor, the force and the speed of the vascular stent entering the test sleeve are controlled by controlling the angular speed change of the rotation of the crank.
In a further embodiment, the rocker is hinged to the guide slide.
In a further embodiment, a hinge is provided on the storage box, and a glass door is provided on the hinge.
The glass can be convenient for better observe the inside condition of containing box, and the hinge can be convenient for better dismantlement and installation.
In a further embodiment, a through groove is formed in the top of the accommodating box body and used for directly connecting the vascular stent with the guide.
The beneficial effects are that: the invention discloses an external loading testing device for a vascular stent, which is characterized in that a guiding part is designed for installing the vascular stent, and a driving part drives a connecting rod part to drive the guiding part to move, so that the vascular stent reciprocates inside and outside a testing sleeve, further the testing work of the vascular stent is completed, and the external loading testing device is simple in structure and convenient to operate and is used for testing the compression fatigue resistance of the vascular stent so as to ensure the use safety of the vascular stent.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a schematic diagram of a stent testing state of the present invention.
Fig. 3 is a detailed structural schematic of the present invention.
The reference numerals are:
1. A link portion; 11. a connecting rod seat; 12. swinging the connecting rod; 13. a connecting rod; 14. a rocker;
2. A driving section; 21. a motor; 22. a crank; 23. a rocker;
3. a guide part; 31. a guide slide plate; 32. a guide rail; 33. a guide bracket;
4. a test section; 42. a test sleeve;
5. A vascular stent.
Detailed Description
The application relates to an intravascular stent in-vitro loading testing device, which is explained in detail below through specific embodiments.
An intravascular stent in vitro loading testing device comprising:
a storage box body;
Further comprises:
a guiding part 3 which is arranged in the storage box body, wherein a vascular stent 5 is arranged on the guiding part 3;
A test part 4 which is arranged in the storage box body and is positioned at one side of the guide part 3 and comprises a test sleeve 42 matched with the vascular stent 5;
A link part 1 provided in the storage case and connected to the guide part 3 to reciprocate the guide part 3;
a driving part 2 installed in the storage box body and connected with the connecting rod part 1;
The driving part 2 drives the connecting rod part 1 to drive the guide part 3 to move, so that the intravascular stent 5 reciprocates inside and outside the test sleeve 42, when the intravascular stent 5 enters the test sleeve 42, the intravascular stent 5 is compressed by the test sleeve 42, and when the intravascular stent comes out of the test sleeve 42, the intravascular stent 5 is spread, and the fatigue strength test of the intravascular stent 5 is finished through repeated compression and spreading.
According to the invention, the vascular stent 5 is installed by designing the guide part 3, and the guide part 3 is driven by the driving part 2 to move by driving the connecting rod part 1, so that the vascular stent 5 reciprocates inside and outside the test sleeve 42, further the test work of the vascular stent 5 is finished, and the vascular stent 5 compression fatigue resistance testing device is simple in structure and convenient to operate and is used for testing the compression fatigue resistance of the vascular stent 5, so that the use safety of the vascular stent 5 is ensured.
The guide part 3 includes:
the guide rail 32 is arranged in the storage box body, and a guide groove is formed in the guide rail 32;
A guide sliding plate 31 arranged in the guide groove and in sliding fit with the guide groove;
a guide bracket 33 mounted on the guide slide plate 31, the guide bracket 33 having a predetermined gradient.
The vascular stent 5 is arranged on the guide stent 33.
When the guide bracket 33 is connected with the blood vessel bracket 5, the blood vessel bracket 5 can be connected with the guide bracket 33 through designing a buckle, and the blood vessel bracket 5 can be connected with the guide bracket 33 through designing the buckle on the guide bracket 33;
The guide bracket 33 and the vascular bracket 5 can be connected through threads, the vascular bracket 5 and the guide bracket 33 can be connected through a bolt or a screw by forming a thread groove on the guide bracket 33;
The guide bracket 33 has a predetermined gradient, so that the vessel bracket 5 can better enter the test sleeve 42 in a reciprocating motion, and the guide bracket 33 and the vessel bracket 5 form detachable connection, so that the vessel bracket 5 can be better assembled and disassembled.
The test sleeve 42 is connected with the storage box body, a chamfer angle with a preset angle is arranged at the end part of the test sleeve 42, and a movement groove is formed in the bottom.
The test sleeve 42 is provided with predetermined angular chamfers at both ends of the inside for better fitting and access of the stent 5, and a movement groove is provided at the bottom of the test sleeve 42 for reciprocating movement of the guide stent 33.
The link portion 1 includes:
The swinging parts are provided with two groups which are respectively arranged in the storage box body and are arranged in parallel, and each group comprises a connecting rod seat 11 arranged in the storage box body and a swinging connecting rod 12 hinged with the connecting rod seat 11;
The two ends of the connecting link 13 are respectively hinged with the swinging links 12 in the two groups of swinging pieces;
and a rocker 14 hinged with any end of the connecting rod 13.
The quick return characteristic of the four-bar mechanism is formed by the two groups of swing connection, the single connecting link 13 and the single rocker 14, and the process of quickly entering the test sleeve 42 after the vascular stent 5 is arranged on the guide stent 33 can simulate the doctor to quickly send the vascular stent 5 into a designated position.
The driving section 2 includes:
a motor 21 disposed inside the storage box;
The crank 22 is connected with the output end of the motor 21;
and a rocker 23 sleeved with the rocker 14 and connected with the crank 22.
By adjusting the rotational speed of the motor 21, the force and speed of the stent 5 as it enters the test sleeve 42 is controlled by controlling the angular speed of rotation of the crank 22.
The rocker 14 is hinged to the guide slide 31.
The storage box body is provided with a hinge, and the hinge is provided with a glass door.
The glass can be convenient for better observe the inside condition of containing box, and the hinge can be convenient for better dismantlement and installation.
The top of the storage box body is provided with a through groove for directly completing connection between the vascular stent 5 and the guide.
Description of working principle: during operation, the motor 21 drives the crank 22 to complete swinging, the rocker 23 is driven to slide along the rocker 14, the rocker 14 is driven to complete swinging, the guide sliding plate 31 is driven to move during swinging, the blood vessel is driven to directly enter the test sleeve 42, the blood vessel bracket 5 can shrink into the test sleeve 42 through the chamfer arranged on the sleeve, and the performance test of the blood vessel bracket 5 is completed through reciprocating entering;
The principle of the test is that the vascular stent 5 is reciprocated in and out from the test sleeve 42, the vascular stent 5 is compressed when entering, the vascular stent 5 is spread when exiting, and the fatigue strength of the vascular stent 5 is tested through multiple times of compression and spreading.
The preferred embodiments of the present invention have been described in detail above with reference to the accompanying drawings, but the present invention is not limited to the specific details of the above embodiments, and various equivalent changes can be made to the technical solutions of the present invention within the scope of the technical concept of the present invention, and these equivalent changes all fall within the protection scope of the present invention.

Claims (3)

1. An intravascular stent in vitro loading testing device comprising:
a storage box body;
Characterized by further comprising:
A guide part (3) which is arranged in the storage box body, wherein a vascular stent (5) is arranged on the guide part (3);
A test part (4) which is arranged in the storage box body and is positioned at one side of the guide part (3) and comprises a test sleeve (42) which is matched with the vascular stent (5);
a connecting rod part (1) arranged in the storage box body and connected with the guide part (3) so as to enable the guide part (3) to reciprocate;
A driving part (2) which is installed in the storage box body and is connected with the connecting rod part (1);
The driving part (2) drives the connecting rod part (1) to drive the guide part (3) to move, so that the vascular stent (5) reciprocates inside and outside the test sleeve (42);
The vascular stent (5) is reciprocated in and out from the test sleeve (42), the vascular stent (5) is compressed when entering, and the vascular stent (5) is spread when exiting;
the guide part (3) comprises:
The guide rail (32) is arranged in the storage box body, and a guide groove is formed in the guide rail (32);
The guide sliding plate (31) is arranged in the guide groove and is in sliding fit with the guide groove;
a guide bracket (33) mounted on the guide slide plate (31);
the vascular stent (5) is arranged on the guide stent (33);
the testing sleeve (42) is connected with the storage box body, a chamfer angle with a preset angle is arranged at the end part of the testing sleeve (42), and a movement groove is formed in the bottom part of the testing sleeve;
The link part (1) includes:
The swinging parts are provided with two groups which are respectively arranged in the storage box body and are arranged in parallel, each group comprises a connecting rod seat (11) arranged in the storage box body and a swinging connecting rod (12) hinged with the connecting rod seat (11);
the two ends of the connecting rod (13) are respectively hinged with the swinging connecting rods (12) in the two groups of swinging pieces;
the rocker (14) is hinged with any end of the connecting rod (13);
The drive unit (2) comprises:
a motor (21) arranged inside the storage box body;
the crank (22) is connected with the output end of the motor (21);
the rocking block (23) is sleeved with the rocking rod (14) and connected with the crank (22);
the rocker (14) is hinged with the guide sliding plate (31).
2. The stent graft in vitro loading testing device of claim 1, wherein: the storage box body is provided with a hinge, and the hinge is provided with a glass door.
3. The stent graft in vitro loading testing device of claim 1, wherein: the top of the storage box body is provided with a through groove.
CN202410061641.1A 2024-01-16 2024-01-16 Vascular stent external loading testing device Active CN117571522B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202410061641.1A CN117571522B (en) 2024-01-16 2024-01-16 Vascular stent external loading testing device

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Application Number Priority Date Filing Date Title
CN202410061641.1A CN117571522B (en) 2024-01-16 2024-01-16 Vascular stent external loading testing device

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CN117571522B true CN117571522B (en) 2024-05-14

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Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004298572A (en) * 2003-04-01 2004-10-28 Aruze Corp Blood fatigue degree sensor
CN206120922U (en) * 2016-07-27 2017-04-26 中国人民解放军第二军医大学 Pipe with annular sacculus
CN107764675A (en) * 2017-09-11 2018-03-06 湖北阳超机电科技有限公司 A kind of knee joint abrasion tester
CN109490110A (en) * 2018-03-29 2019-03-19 中国科学院金属研究所 With the Corrosion Fatigue Crack Propagation experimental rig of high temperature and pressure recirculated water and its application
CN209606068U (en) * 2019-03-04 2019-11-08 深圳市美好创亿医疗科技有限公司 Silicon stent device for testing endurance
CN112198053A (en) * 2020-09-29 2021-01-08 江苏理工学院 External loading device for blood vessel stent
CN112255129A (en) * 2020-10-22 2021-01-22 江苏理工学院 External torsion loading device for intravascular stent
CN112255128A (en) * 2020-10-22 2021-01-22 江苏理工学院 Vascular stent mechanics loading device
CN218995021U (en) * 2022-12-02 2023-05-09 上海臻亿医疗科技有限公司 Fatigue testing device

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6810751B2 (en) * 2002-07-29 2004-11-02 Michael R. Moreno Method and apparatus for vascular durability and fatigue testing

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004298572A (en) * 2003-04-01 2004-10-28 Aruze Corp Blood fatigue degree sensor
CN206120922U (en) * 2016-07-27 2017-04-26 中国人民解放军第二军医大学 Pipe with annular sacculus
CN107764675A (en) * 2017-09-11 2018-03-06 湖北阳超机电科技有限公司 A kind of knee joint abrasion tester
CN109490110A (en) * 2018-03-29 2019-03-19 中国科学院金属研究所 With the Corrosion Fatigue Crack Propagation experimental rig of high temperature and pressure recirculated water and its application
CN209606068U (en) * 2019-03-04 2019-11-08 深圳市美好创亿医疗科技有限公司 Silicon stent device for testing endurance
CN112198053A (en) * 2020-09-29 2021-01-08 江苏理工学院 External loading device for blood vessel stent
CN112255129A (en) * 2020-10-22 2021-01-22 江苏理工学院 External torsion loading device for intravascular stent
CN112255128A (en) * 2020-10-22 2021-01-22 江苏理工学院 Vascular stent mechanics loading device
CN218995021U (en) * 2022-12-02 2023-05-09 上海臻亿医疗科技有限公司 Fatigue testing device

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Simulations of Self-Expanding Braided Stent Using Macroscopic Model of NiTi Shape Memory Alloys Covering R-Phase;M. Frost等;《Journal of Materials Engineering and Performance》;20140408;第23卷(第7期);第2584-2590页 *
基于Sim Vascular的腹主动脉复杂模型构建与血流动力学仿真研究;吴全玉等;《江苏理工学院学报》;20190430;第25卷(第2期);第2-9页 *
非血管支架疲劳性能体外试验装置;李雨轩等;《实验技术与管理》;20230531;第40卷(第5期);第154-159页 *

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