CN117546242A - 基于蛋白质结构的蛋白质语言模型 - Google Patents

基于蛋白质结构的蛋白质语言模型 Download PDF

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Publication number
CN117546242A
CN117546242A CN202280043979.3A CN202280043979A CN117546242A CN 117546242 A CN117546242 A CN 117546242A CN 202280043979 A CN202280043979 A CN 202280043979A CN 117546242 A CN117546242 A CN 117546242A
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amino acid
pathogenicity
protein
amino acids
computer
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CN202280043979.3A
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English (en)
Chinese (zh)
Inventor
T·汉普
H·高
K-H·法尔
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Inmair Ltd
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Inmair Ltd
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Priority claimed from US17/533,091 external-priority patent/US11538555B1/en
Application filed by Inmair Ltd filed Critical Inmair Ltd
Priority claimed from PCT/US2022/045825 external-priority patent/WO2023059752A1/en
Publication of CN117546242A publication Critical patent/CN117546242A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/20—Heterogeneous data integration

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  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Data Mining & Analysis (AREA)
  • Molecular Biology (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Epidemiology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Probability & Statistics with Applications (AREA)
  • Physiology (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Computing Systems (AREA)
  • Biomedical Technology (AREA)
CN202280043979.3A 2021-10-06 2022-10-05 基于蛋白质结构的蛋白质语言模型 Pending CN117546242A (zh)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US202163253122P 2021-10-06 2021-10-06
US63/253122 2021-10-06
US202163281579P 2021-11-19 2021-11-19
US202163281592P 2021-11-19 2021-11-19
US63/281579 2021-11-19
US63/281592 2021-11-19
US17/533091 2021-11-22
US17/533,091 US11538555B1 (en) 2021-10-06 2021-11-22 Protein structure-based protein language models
US17/953293 2022-09-26
US17/953286 2022-09-26
US17/953,286 US20230108241A1 (en) 2021-10-06 2022-09-26 Predicting variant pathogenicity from evolutionary conservation using three-dimensional (3d) protein structure voxels
US17/953,293 US20230108368A1 (en) 2021-10-06 2022-09-26 Combined and transfer learning of a variant pathogenicity predictor using gapped and non-gapped protein samples
PCT/US2022/045825 WO2023059752A1 (en) 2021-10-06 2022-10-05 Protein structure-based protein language models

Publications (1)

Publication Number Publication Date
CN117546242A true CN117546242A (zh) 2024-02-09

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CN202280043979.3A Pending CN117546242A (zh) 2021-10-06 2022-10-05 基于蛋白质结构的蛋白质语言模型
CN202280046302.5A Pending CN117642824A (zh) 2021-10-06 2022-10-05 使用三维(3d)蛋白质结构体素根据进化保守性预测变体致病性

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202280046302.5A Pending CN117642824A (zh) 2021-10-06 2022-10-05 使用三维(3d)蛋白质结构体素根据进化保守性预测变体致病性

Country Status (4)

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EP (3) EP4413577A1 (https=)
JP (3) JP2024538478A (https=)
KR (3) KR20240088641A (https=)
CN (2) CN117546242A (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117121110A (zh) * 2021-04-15 2023-11-24 因美纳有限公司 用于深度学习的高效体素化
CN118629516A (zh) * 2024-05-17 2024-09-10 安徽农业大学 一种基于多模态特征和孪生网络的神经肽预测方法及系统

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119560009B (zh) * 2025-01-22 2025-06-24 浙江工业大学 一种蛋白质翻译后修饰与疾病关联预测系统及方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117121110A (zh) * 2021-04-15 2023-11-24 因美纳有限公司 用于深度学习的高效体素化
CN118629516A (zh) * 2024-05-17 2024-09-10 安徽农业大学 一种基于多模态特征和孪生网络的神经肽预测方法及系统

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Publication number Publication date
JP2024538478A (ja) 2024-10-23
EP4413575A1 (en) 2024-08-14
KR20240082270A (ko) 2024-06-10
KR20240082269A (ko) 2024-06-10
EP4413577A1 (en) 2024-08-14
EP4413576A1 (en) 2024-08-14
CN117642824A (zh) 2024-03-01
KR20240088641A (ko) 2024-06-20
JP2024538477A (ja) 2024-10-23
JP2024538475A (ja) 2024-10-23

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