CN117530367A - Astaxanthin composition and preparation method and application thereof - Google Patents
Astaxanthin composition and preparation method and application thereof Download PDFInfo
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- CN117530367A CN117530367A CN202311554435.6A CN202311554435A CN117530367A CN 117530367 A CN117530367 A CN 117530367A CN 202311554435 A CN202311554435 A CN 202311554435A CN 117530367 A CN117530367 A CN 117530367A
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- astaxanthin
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- composition
- astaxanthin composition
- homogenization
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- 239000001168 astaxanthin Substances 0.000 title claims abstract description 191
- 229940022405 astaxanthin Drugs 0.000 title claims abstract description 191
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 title claims abstract description 178
- 235000013793 astaxanthin Nutrition 0.000 title claims abstract description 178
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 title claims abstract description 178
- 239000000203 mixture Substances 0.000 title claims abstract description 107
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 19
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 18
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 18
- 239000004519 grease Substances 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000004094 surface-active agent Substances 0.000 claims abstract description 12
- 238000000265 homogenisation Methods 0.000 claims description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 32
- 238000000034 method Methods 0.000 claims description 25
- 238000001035 drying Methods 0.000 claims description 24
- 239000002502 liposome Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 10
- 238000005507 spraying Methods 0.000 claims description 10
- 239000003755 preservative agent Substances 0.000 claims description 9
- 230000002335 preservative effect Effects 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 239000003921 oil Substances 0.000 claims description 3
- 235000019198 oils Nutrition 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 claims description 2
- IMOYOUMVYICGCA-UHFFFAOYSA-N 2-tert-butyl-4-hydroxyanisole Chemical compound COC1=CC=C(O)C=C1C(C)(C)C IMOYOUMVYICGCA-UHFFFAOYSA-N 0.000 claims description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical group CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 2
- 241000168517 Haematococcus lacustris Species 0.000 claims description 2
- 235000019483 Peanut oil Nutrition 0.000 claims description 2
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- 235000012682 canthaxanthin Nutrition 0.000 claims description 2
- 239000001659 canthaxanthin Substances 0.000 claims description 2
- 229940008033 canthaxanthin Drugs 0.000 claims description 2
- 235000012000 cholesterol Nutrition 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims description 2
- -1 fatty acid propylene glycol ester Chemical class 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000944 linseed oil Substances 0.000 claims description 2
- 235000021388 linseed oil Nutrition 0.000 claims description 2
- 239000000312 peanut oil Substances 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 239000010464 refined olive oil Substances 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 24
- 230000004083 survival effect Effects 0.000 abstract description 23
- 241001465754 Metazoa Species 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 5
- 239000003674 animal food additive Substances 0.000 abstract description 4
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 31
- 241000276703 Oreochromis niloticus Species 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 11
- 239000007921 spray Substances 0.000 description 11
- 230000004584 weight gain Effects 0.000 description 9
- 235000019786 weight gain Nutrition 0.000 description 9
- 238000009472 formulation Methods 0.000 description 7
- 238000009360 aquaculture Methods 0.000 description 6
- 244000144974 aquaculture Species 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 238000012136 culture method Methods 0.000 description 5
- 238000013401 experimental design Methods 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 241000252230 Ctenopharyngodon idella Species 0.000 description 4
- 241000238557 Decapoda Species 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 241000251468 Actinopterygii Species 0.000 description 3
- 241000972773 Aulopiformes Species 0.000 description 3
- 235000019688 fish Nutrition 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 235000019515 salmon Nutrition 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 241001125889 Micropterus salmoides Species 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000003859 lipid peroxidation Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 description 1
- 241000881711 Acipenser sturio Species 0.000 description 1
- 241000271566 Aves Species 0.000 description 1
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
- 241001282110 Pagrus major Species 0.000 description 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000010331 calcium propionate Nutrition 0.000 description 1
- 239000004330 calcium propionate Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/168—Steroids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3481—Organic compounds containing oxygen
- A23L3/3508—Organic compounds containing oxygen containing carboxyl groups
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
- Y02A40/818—Alternative feeds for fish, e.g. in aquacultures
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Marine Sciences & Fisheries (AREA)
- Insects & Arthropods (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses an astaxanthin composition, a preparation method and application thereof, and relates to the technical field of feed additives. The astaxanthin composition comprises the following components in parts by weight: 10-25 parts of biological film, 2-3 parts of astaxanthin, 2-5 parts of antioxidant, 2-5 parts of curing agent, 4-6 parts of surfactant and 40-60 parts of grease. According to the invention, the astaxanthin composition with long quality guarantee period and stable activity is prepared by optimizing the formula and the preparation method of the astaxanthin composition, so that the problem that astaxanthin is easy to deactivate at high temperature and under visible light is solved; the astaxanthin composition is sprayed on the surface of the puffed feed, so that the oxidation resistance and immunity of animal organisms can be effectively improved, and the survival rate of animals can be improved; meanwhile, the invention has simple production process and lower production cost.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to an astaxanthin composition, a preparation method and application thereof.
Background
Astaxanthin is a chain-breaking antioxidant, has extremely strong antioxidant capacity, can remove nitrogen dioxide, sulfide, disulfide and the like, can reduce lipid peroxidation, and effectively inhibits lipid peroxidation caused by free radicals. Astaxanthin is widely applied in aquaculture, is mainly used as a feed additive for fishes (salmon, sturgeon, rainbow trout, red sea bream and the like) and shrimps and crabs and the like, and can enable aquatic animals to have bright color and luster and higher ornamental value; meanwhile, the astaxanthin has the same functions as human beings in preventing and treating diseases of fishes, shrimps, crabs and birds, can improve immunity and survival rate, and has important functions on normal growth and healthy cultivation, survival rate and reproduction rate; astaxanthin also increases fish flavor, either directly as a precursor compound for the flavor of salmon food or to promote the conversion of fatty acids or other lipid precursors to salmon flavor compounds. However, since astaxanthin contains many long unsaturated conjugated double bonds in its molecular structure, its properties are extremely unstable, and it is sensitive to light, heat, oxygen, etc., resulting in a great decrease in antioxidant ability in practical applications.
At present, when the feed is processed, the astaxanthin activity is reduced due to light, heat and other reasons, so that a plurality of researches adopt means such as a dry preservation method, a reduction of storage temperature, a reduction of contact time with air and the like to relieve the degradation process of the astaxanthin. However, these methods have unsatisfactory effects in the application of the puffed feed, and do not meet the requirements of the aquatic puffed feed well, so that the application of astaxanthin in the aquatic puffed feed is greatly limited.
Aiming at the problems of the astaxanthin in the feed application, the astaxanthin composition with high activity, strong stability and long storage time is found to be the focus of research in the field of the current feed additives.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an astaxanthin composition with strong stability, long storage time and higher astaxanthin activity in the composition, and a preparation method and application thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
an astaxanthin composition comprising the following components in parts by weight: 10-25 parts of biological film, 2-3 parts of astaxanthin, 2-5 parts of antioxidant, 2-5 parts of curing agent, 4-6 parts of surfactant and 40-60 parts of grease.
According to the invention, through the mutual matching of the components, the astaxanthin composition with long quality guarantee period and stable activity is prepared, and the problem that astaxanthin is easy to deactivate under high temperature and visible light is solved; the astaxanthin composition is sprayed on the surface of the puffed feed, so that the oxidation resistance and immunity of animal organisms can be effectively improved, and the survival rate of animals can be improved.
As a preferred embodiment of the astaxanthin composition according to the present invention, said astaxanthin composition comprises the following components in parts by weight: 20 parts of biological film, 3 parts of astaxanthin, 4 parts of antioxidant, 3 parts of curing agent, 5 parts of surfactant and 55 parts of grease; the inventor discovers through a large number of experiments that the growth performance and the survival rate of the feed prepared by the astaxanthin composition under the conditions of the weight portions are remarkably improved.
As a preferred embodiment of the astaxanthin composition according to the present invention, at least one of the following is used:
(1) The biofilm comprises lysolecithin and cholesterol;
(2) The astaxanthin comprises at least one of haematococcus pluvialis astaxanthin, rhodozyma-derived astaxanthin and astaxanthin synthesized by a canthaxanthin conversion method;
(3) The antioxidant is 2, 6-di-tert-butyl-p-cresol (BHT) or tert-butyl-4-hydroxy anisole (BHA);
(4) The curing agent is L-polylactic acid;
(5) The surfactant is acrylic ester copolymer or fatty acid propylene glycol ester;
(6) The grease comprises at least one of vitamin E oil, refined olive oil, peanut oil and linseed oil.
As a preferred embodiment of the astaxanthin composition according to the present invention, a preservative is further included in the astaxanthin composition, and the preservative is present in an amount of 3-5 parts by weight.
As a more preferred embodiment of the astaxanthin composition according to the present invention, said preservative comprises at least one of potassium sorbate, sodium benzoate, calcium propionate.
The invention also provides a preparation method of the astaxanthin composition, which comprises the following steps:
s1, mixing a biomembrane, an antioxidant, a preservative and astaxanthin, and homogenizing by ultrasonic to obtain liquid astaxanthin;
s2, carrying out ultrasonic homogenization on the liquid astaxanthin obtained in the step S1 in water to obtain suspended liposome-astaxanthin;
s3, adding a curing agent into the suspended liposome-astaxanthin in the step S2, continuing ultrasonic homogenization, and drying to obtain powdery liposome astaxanthin;
and S4, adding the powdery liposome astaxanthin in the step S3 into grease, adding a surfactant, and homogenizing and mixing to obtain the astaxanthin composition.
As a preferred embodiment of the method for preparing an astaxanthin composition according to the present invention, in the step S1, the parameters of homogenization are: the temperature is 40-55deg.C, the ultrasonic frequency is 2500-4500Hz, and the homogenizing time is 5-8min; the inventor finds through a large number of experiments that if the temperature is lower than 40 ℃, the ultrasonic frequency is lower than 2500Hz, and the homogenizing time is lower than 5min, astaxanthin cannot be uniformly distributed in the system, and layering phenomenon is easy to occur; if the temperature is higher than 55℃and the ultrasonic frequency is higher than 4500Hz, the homogenization time exceeds 8min, and astaxanthin may be partially deactivated due to the higher temperature or the ultrasonic frequency being too high.
As a preferred embodiment of the method for preparing an astaxanthin composition according to the present invention, in the step S2, the parameters of homogenization are: the temperature is 30-35 ℃, the ultrasonic frequency is 5000-7500Hz, and the homogenizing time is 5-8min; the inventor finds through a large number of experiments that if the temperature is lower than 30 ℃, the ultrasonic frequency is lower than 5000Hz, and the homogenization time is lower than 5min, the dispersion effect of astaxanthin in a pure water system is poor, and the yield of liposome astaxanthin is affected; if the temperature is higher than 35 ℃, the ultrasonic frequency is higher than 7500Hz, the homogenization time exceeds 8min, and the astaxanthin can easily overflow, thereby influencing the encapsulation efficiency of the astaxanthin.
As a preferred embodiment of the method for preparing an astaxanthin composition according to the present invention, in the step S3, the homogenizing time is 5-10min; the inventor finds through a large number of experiments that the homogenization time is lower than 5 minutes, so that the suspended liquid astaxanthin cannot be completely solidified; if the homogenization time is more than 10 minutes, the liposome astaxanthin which is solidified originally is easily combined with the newly generated liposome astaxanthin to form large granular liposome astaxanthin, which affects the activity of astaxanthin in the final composition.
As a preferred embodiment of the preparation method of astaxanthin composition according to the present invention, in the step S3, the drying temperature is 60-65 ℃ and the drying time is 30-50min, and the inventors have found through a lot of experiments that if the drying temperature is lower than 60 ℃ and the drying time is lower than 30min, the drying effect of the liposomal astaxanthin is poor and there is a phenomenon of partial wall hanging; if the drying temperature is higher than 65 ℃ and the drying time exceeds 50min, the liposome astaxanthin can start to change color, the liposome coating effect is poor, and the astaxanthin is oxidized.
As a preferred embodiment of the method for preparing an astaxanthin composition according to the present invention, in the step S4, the ultrasonic frequency is 5000-7500Hz; the inventor finds through a large number of experiments that if the ultrasonic frequency is lower than 5000HZ, then the powder liposome astaxanthin cannot be uniformly mixed in an oil system, so that the post-spraying effect is uneven, and the using effect is affected; if the ultrasonic frequency exceeds 7500HZ, a large amount of bubbles can be generated in the grease system after a period of time, the using effect of post-spraying equipment is affected, and the air spraying phenomenon can be caused by the influence of the bubbles.
The invention also provides application of the astaxanthin composition in puffed feed.
As a preferred embodiment of the use of the astaxanthin composition according to the present invention in expanded feed, said astaxanthin composition is sprayed onto the surface of the expanded feed by means of a post-spraying device.
As a preferred embodiment of the use of the astaxanthin composition according to the present invention in a puffed feed, the astaxanthin composition is present in the puffed feed in a mass percentage of 0.5% -1%.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the astaxanthin composition with long quality guarantee period and stable activity is prepared by optimizing the formula and the preparation method of the astaxanthin composition, so that the problem that astaxanthin is easy to deactivate at high temperature and under visible light is solved; the astaxanthin composition is sprayed on the surface of the puffed feed, so that the oxidation resistance and immunity of animal organisms can be effectively improved, and the survival rate of animals can be improved; meanwhile, the invention has simple production process and lower production cost.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
The reagents, methods and apparatus employed in the present invention, unless otherwise specified, are all conventional in the art.
When the parts by weight of the components involved in the examples and comparative examples of the present invention were changed, the void or deficiency generated by the change was maintained at 100 parts by the amount of deionized water.
Example 1
The formula of the astaxanthin composition according to example 1 of the present invention is shown in Table 1, and the preparation method of the astaxanthin composition comprises the following steps:
s1, mixing a biomembrane, an antioxidant, a preservative and astaxanthin according to a formula in a table 1, and carrying out ultrasonic homogenization to obtain liquid astaxanthin, wherein parameters of homogenization are as follows: the temperature is 40 ℃, the ultrasonic frequency is 4500Hz, and the homogenizing time is 5min;
s2, carrying out ultrasonic homogenization on the liquid astaxanthin in the step S1 in water to obtain suspended liposome-astaxanthin, wherein the homogenization parameters are as follows: the temperature is 30 ℃, the ultrasonic frequency is 5000Hz, and the homogenizing time is 5min;
s3, adding a curing agent into the suspended liposome-astaxanthin in the step S2, continuing ultrasonic homogenization, and drying to obtain powdery liposome-astaxanthin, wherein the homogenization time is 5min, the drying temperature is 60 ℃, and the drying time is 30min;
s4, adding the powdery liposome astaxanthin in the step S3 into grease, adding a surfactant, and homogenizing and mixing to obtain the astaxanthin composition, wherein the ultrasonic frequency is 5000Hz.
Example 2
The formulation of the astaxanthin composition according to this example is shown in Table 1, and the preparation method of the astaxanthin composition comprises the following steps:
s1, mixing a biomembrane, an antioxidant, a preservative and astaxanthin according to a formula in a table 1, and carrying out ultrasonic homogenization to obtain liquid astaxanthin, wherein parameters of homogenization are as follows: the temperature is 45 ℃, the ultrasonic frequency is 4500Hz, and the homogenizing time is 6min;
s2, carrying out ultrasonic homogenization on the liquid astaxanthin in the step S1 in water to obtain suspended liposome-astaxanthin, wherein the homogenization parameters are as follows: the temperature is 35 ℃, the ultrasonic frequency is 6000Hz, and the homogenizing time is 5min;
s3, adding a curing agent into the suspended liposome-astaxanthin in the step S2, continuing ultrasonic homogenization, and drying to obtain powdery liposome-astaxanthin, wherein the homogenization time is 8min, the drying temperature is 65 ℃, and the drying time is 30-50min;
s4, adding the powdery liposome astaxanthin in the step S3 into grease, adding a surfactant, and homogenizing and mixing to obtain the astaxanthin composition, wherein the ultrasonic frequency is 6000Hz.
Example 3
The formulation of the astaxanthin composition according to this example is shown in Table 1, and the preparation method of the astaxanthin composition comprises the following steps:
s1, mixing a biomembrane, an antioxidant, a preservative and astaxanthin according to a formula in a table 1, and carrying out ultrasonic homogenization to obtain liquid astaxanthin, wherein parameters of homogenization are as follows: the temperature is 55 ℃, the ultrasonic frequency is 4500Hz, and the homogenizing time is 8min;
s2, carrying out ultrasonic homogenization on the liquid astaxanthin in the step S1 in water to obtain suspended liposome-astaxanthin, wherein the homogenization parameters are as follows: the temperature is 35 ℃, the ultrasonic frequency is 7500Hz, and the homogenizing time is 5min;
s3, adding a curing agent into the suspended liposome-astaxanthin in the step S2, continuing ultrasonic homogenization, and drying to obtain powdery liposome-astaxanthin, wherein the homogenization time is 10min, the drying temperature is 65 ℃, and the drying time is 30-50min;
s4, adding the powdery liposome astaxanthin in the step S3 into grease, adding a surfactant, and homogenizing and mixing to obtain the astaxanthin composition, wherein the ultrasonic frequency is 7500Hz.
Example 4
The formulation of the astaxanthin composition according to this example is shown in Table 1, and the astaxanthin composition is prepared according to the same method as in example 1.
Example 5
The formulation of the astaxanthin composition according to this example is shown in Table 1, and the astaxanthin composition is prepared according to the same method as in example 1.
Comparative examples 1 to 2
Comparative examples 1-2 of the present invention differ from example 1 only in that: the astaxanthin compositions were formulated differently, and the astaxanthin compositions according to comparative examples 1-2 were prepared according to the same method and parameters as in example 1, as specified in Table 1 below.
Comparative example 3
Comparative example 3 of the present invention corresponds to the formulation of the astaxanthin composition described in example 1, with the only difference that: the preparation parameters in the preparation method of the astaxanthin composition are different, and the preparation parameters are as follows:
in the step S1, the parameters of homogenization are: the temperature is 30 ℃, the ultrasonic frequency is 1500Hz, and the homogenizing time is 2min;
in the step S2, the parameters of homogenization are: the temperature is 20 ℃, the ultrasonic frequency is 3000Hz, and the homogenizing time is 2min;
in the step S3, the homogenizing time is 2min; the drying temperature is 40 ℃ and the drying time is 20min;
in the step S4, the ultrasonic frequency is 3000Hz.
Comparative example 4
Comparative example 4 of the present invention corresponds to the formulation of the astaxanthin composition described in example 1, with the only difference that: the preparation parameters in the preparation method of the astaxanthin composition are different, and the preparation parameters are as follows:
in the step S1, the parameters of homogenization are: the temperature is 70 ℃, the ultrasonic frequency is 5000Hz, and the homogenizing time is 15min;
in the step S2, the parameters of homogenization are: the temperature is 50 ℃, the ultrasonic frequency is 8000Hz, and the homogenizing time is 10min;
in the step S3, the homogenizing time is 20min; the drying temperature is 80 ℃ and the drying time is 60min;
in the step S4, the ultrasonic frequency is 8000Hz.
TABLE 1
Test example 1
The astaxanthin composition described in example 1 was sprayed on the surface of the puffed feed using a post-spraying apparatus at 25kg astaxanthin composition per ton of puffed feed, and the astaxanthin content in the feed was quantitatively determined by sampling and an aquaculture test was performed. The test object is nile tilapia, and the average weight is 30.15g; the experimental design was divided into A, B, C groups of 3 replicates each with 50 tails of each replicate. Wherein group A is a normal puffed feed (blank group) without post-spray astaxanthin, group B is a puffed feed (control group) with astaxanthin directly added thereto, and group C is a puffed feed (test group) with astaxanthin composition prepared in example 1 added thereto by post-spray technique; the influence of water flow exchange among groups is prevented by adopting a still water culture method. The operation is carried out according to the normal feeding flow of the nile tilapia, so that the water temperature, the pH value, the dissolved oxygen and the like are ensured to be in proper ranges, the water temperature is measured once every morning and afternoon every day, and the water quality is measured once every two weeks; the feeding period is 10 weeks; the change in growth performance of nile tilapia of example 1 is shown in table 2 below.
The puffed feed disclosed by the invention is a conventional puffed feed for nile tilapia, which is prepared by a feed factory.
TABLE 2
| Index (I) | Blank group | Control group | Test group |
| Relative weight gain (%) | 182.25 | 190.41 | 240.36 |
| Coefficient of bait | 2.05 | 1.87 | 1.62 |
| Survival rate (%) | 89.52 | 91.42 | 97.42 |
As can be seen from the results in Table 2, the astaxanthin composition of the present invention has a long shelf life and high activity, and compared with the blank group and the control group, the use of the puffed feed containing the astaxanthin composition of the present invention has a significant effect on the growth performance and survival rate of the Nile tilapia; the weight gain rate of the test group is improved by 31.88 percent compared with that of the blank group and the control group, the survival rate is improved by 14.43 percent compared with that of the blank group and the control group, the survival rate is improved by 9.52 percent, and the bait coefficient is reduced by 0.43 and 0.25 compared with that of the blank group and the control group.
Test example 2
The astaxanthin composition described in example 2 was sprayed on the surface of the puffed feed using a post-spraying apparatus at 15kg astaxanthin composition per ton of puffed feed, and the astaxanthin content in the feed was quantitatively determined by sampling and an aquaculture test was performed. The test object is grass carp, and the average weight is 346 g/strip; the experimental design was divided into A, B, C groups of 3 replicates each with 50 tails of each replicate. Wherein group A is a normal puffed feed (blank group) without post-spray astaxanthin, group B is a puffed feed (control group) with astaxanthin directly added thereto, and group C is a puffed feed (test group) with astaxanthin composition prepared in example 2 by post-spray technique; the influence of water flow exchange among groups is prevented by adopting a still water culture method. The normal feeding process of grass carp is operated in the period, so that the water temperature, the pH value, the dissolved oxygen and the like are in proper ranges, the water temperature is measured once every morning and afternoon every day, and the water quality is measured once every two weeks; the feeding period is 10 weeks; the change in growth performance of grass carp of example 2 is shown in table 3 below.
TABLE 3 Table 3
| Index (I) | Blank group | Control group | Test group |
| Relative weight gain (%) | 65.55 | 68.36 | 76.25 |
| Coefficient of bait | 1.45 | 1.32 | 1.02 |
| Survival rate (%) | 90.21 | 92.42 | 97.35 |
As can be seen from the results in Table 3, the astaxanthin composition of the present invention has a long shelf life and high activity, and compared with the blank group and the control group, the puffed feed using the astaxanthin composition of the present invention has a significant effect on the growth performance and survival rate of grass carp; as shown in Table 3, the weight gain rate of the test group is improved by 16.32% compared with that of the blank group and the control group, the survival rate is improved by 7.91% compared with that of the blank group and the control group, the survival rate is improved by 5.33%, and the bait coefficient is reduced by 0.43 and 0.3 compared with that of the blank group and the control group.
Test example 3
The astaxanthin composition described in example 3 was sprayed on the surface of the puffed feed using a post-spraying apparatus at 15kg astaxanthin composition per ton of puffed feed, and the astaxanthin content in the feed was quantitatively determined by sampling and an aquaculture test was performed. The test object is a weever with the average weight of 211 g/strip; the experimental design was divided into A, B, C groups of 3 replicates each with 50 tails of each replicate. Wherein group A is a normal puffed feed (blank group) without post-spray astaxanthin, group B is a puffed feed (control group) with astaxanthin directly added thereto, and group C is a puffed feed (test group) with astaxanthin composition prepared in example 3 added thereto by post-spray technique; the influence of water flow exchange among groups is prevented by adopting a still water culture method. The method is operated according to the normal feeding flow of the weever in California, so that the water temperature, the pH, the dissolved oxygen and the like are all in proper ranges, the water temperature is measured once every morning and afternoon every other day, and the water quality is measured once every two weeks; the feeding period is 10 weeks; the changes in growth performance of the micropterus salmoides of example 3 are shown in Table 4 below.
TABLE 4 Table 4
The results in Table 4 show that the astaxanthin composition of the present invention has long shelf life and high activity, and compared with the blank group and the control group, the puffed feed using the post-spray astaxanthin of the present invention has significant influence on the growth performance and survival rate of the micropterus salmoides; as shown in Table 4, the weight gain rate of the test group is improved by 38.85 percent compared with that of the blank group and the control group, the survival rate is improved by 7.94 percent and 5.88 percent respectively compared with that of the blank group and the control group, and the bait coefficient is reduced by 0.35 and 0.24 respectively compared with that of the blank group and the control group.
Test example 4
The astaxanthin composition described in example 4 was sprayed on the surface of the puffed feed using a post-spraying apparatus at 25kg astaxanthin composition per ton of puffed feed, and the astaxanthin content in the feed was quantitatively determined by sampling and an aquaculture test was performed. The test object is nile tilapia, and the average weight is 30.42g; the experimental design was divided into A, B, C groups of 3 replicates each with 50 tails of each replicate. Wherein group A is a normal puffed feed (blank group) without post-spray astaxanthin, group B is a puffed feed (control group) with astaxanthin directly added thereto, and group C is a puffed feed (test group) with astaxanthin composition prepared in example 4 by post-spray technique; the influence of water flow exchange among groups is prevented by adopting a still water culture method. The operation is carried out according to the normal feeding flow of the nile tilapia, so that the water temperature, the pH value, the dissolved oxygen and the like are ensured to be in proper ranges, the water temperature is measured once every morning and afternoon every day, and the water quality is measured once every two weeks; the feeding period is 10 weeks; the change in growth performance of nile tilapia of example 4 is shown in table 5 below.
TABLE 5
| Index (I) | Blank group | Control group | Test group |
| Relative weight gain (%) | 178.32 | 191.64 | 251.24 |
| Coefficient of bait | 2.26 | 1.92 | 1.52 |
| Survival rate (%) | 88.52 | 92.45 | 99.41 |
As is clear from the results of Table 5, the astaxanthin composition of the present invention has a long shelf life and high activity, and the use of the puffed feed containing the astaxanthin composition of the present invention has a significant effect on the growth performance and survival rate of Nile tilapia, as compared with the blank group and the control group. Compared with the blank group and the control group, the relative weight gain rate of the test group is respectively increased by 40.89 percent, 31.09 percent, the survival rate is respectively increased by 12.30 percent, 7.52 percent, and the bait coefficient is respectively decreased by 0.74,0.4 percent.
Test example 5
The astaxanthin composition described in example 5 was sprayed on the surface of the puffed feed using a post-spraying apparatus at 25kg astaxanthin composition per ton of puffed feed, and the astaxanthin content in the feed was quantitatively determined by sampling and an aquaculture test was performed. The test object is nile tilapia, and the average weight is 31.26g; the experimental design was divided into A, B, C groups of 3 replicates each with 50 tails of each replicate. Wherein group A is a normal puffed feed (blank group) without post-spray astaxanthin, group B is a puffed feed (control group) with astaxanthin directly added thereto, and group C is a puffed feed (test group) with astaxanthin composition prepared in example 5 by post-spray technique; the influence of water flow exchange among groups is prevented by adopting a still water culture method. The operation is carried out according to the normal feeding flow of the nile tilapia, so that the water temperature, the pH value, the dissolved oxygen and the like are ensured to be in proper ranges, the water temperature is measured once every morning and afternoon every day, and the water quality is measured once every two weeks; the feeding period is 10 weeks; the change in growth performance of nile tilapia of example 5 is shown in table 6 below.
The puffed feed disclosed by the invention is a conventional puffed feed for nile tilapia, which is prepared by a feed factory.
TABLE 6
| Index (I) | Blank group | Control group | Test group |
| Relative weight gain (%) | 181.53 | 188.85 | 255.62 |
| Coefficient of bait | 2.08 | 1.76 | 1.48 |
| Survival rate (%) | 90.43 | 91.66 | 99.53 |
As is clear from the results of Table 6, the astaxanthin composition of the present invention has a long shelf life and high activity, and the use of the puffed feed containing the astaxanthin composition of the present invention has a significant effect on the growth performance and survival rate of Nile tilapia, as compared with the blank group and the control group. The weight gain rate of the test group is increased by 40.81 percent, 35.35 percent, the survival rate is increased by 10.06 percent, 8.58 percent and the bait coefficient is decreased by 0.60,0.28 percent compared with the blank group and the control group respectively.
Test example 6
The astaxanthin compositions according to examples of the present invention and comparative example were stored at room temperature for 90 days, sampled periodically, and the antioxidant activity of astaxanthin was measured by DPPH-free radical assay, and the test results are shown in Table 7 below; the common astaxanthin is untreated astaxanthin.
TABLE 7
As can be seen from Table 7, the astaxanthin composition according to the example of the present invention has a relatively excellent antioxidant ability, and in particular, the composition according to example 5 has the most excellent antioxidant ability; comparative examples 1 and 2 since the formulation of the composition was not within the scope of the present invention, comparative examples 3 and 4 since the preparation parameters were not within the scope of the present invention, the antioxidant capacity of the final composition was not as good as that of the examples.
In summary, the astaxanthin composition with long quality guarantee period and stable activity is prepared by optimizing the formula and the preparation method of the astaxanthin composition, and the problem that astaxanthin is easy to inactivate under high temperature and visible light is solved; the astaxanthin composition is sprayed on the surface of the puffed feed, so that the oxidation resistance and immunity of animal organisms can be effectively improved, and the survival rate of animals can be improved; meanwhile, the invention has simple production process and lower production cost.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention and not for limiting the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that the technical solution of the present invention may be modified or substituted equally without departing from the spirit and scope of the technical solution of the present invention.
Claims (10)
1. An astaxanthin composition, characterized in that the astaxanthin composition comprises the following components in parts by weight: 10-25 parts of biological film, 2-3 parts of astaxanthin, 2-5 parts of antioxidant, 2-5 parts of curing agent, 4-6 parts of surfactant and 40-60 parts of grease.
2. The astaxanthin composition of claim 1, wherein the astaxanthin composition comprises the following components in parts by weight: 20 parts of biological film, 3 parts of astaxanthin, 4 parts of antioxidant, 3 parts of curing agent, 5 parts of surfactant and 55 parts of grease.
3. Astaxanthin composition according to claim 1 or 2, characterized in that at least one of the following is used:
(1) The biofilm comprises lysolecithin and cholesterol;
(2) The astaxanthin comprises at least one of haematococcus pluvialis astaxanthin, rhodozyma-derived astaxanthin and astaxanthin synthesized by a canthaxanthin conversion method;
(3) The antioxidant is 2, 6-di-tert-butyl-p-cresol or tert-butyl-4-hydroxy anisole;
(4) The curing agent is L-polylactic acid;
(5) The surfactant is acrylic ester copolymer or fatty acid propylene glycol ester;
(6) The grease comprises at least one of vitamin E oil, refined olive oil, peanut oil and linseed oil;
(7) The astaxanthin composition also comprises 3-5 parts by weight of preservative.
4. A process for the preparation of an astaxanthin composition according to any one of claims 1-3, wherein said process comprises the steps of:
s1, mixing a biomembrane, an antioxidant, a preservative and astaxanthin, and homogenizing by ultrasonic to obtain liquid astaxanthin;
s2, carrying out ultrasonic homogenization on the liquid astaxanthin obtained in the step S1 in water to obtain suspended liposome-astaxanthin;
s3, adding a curing agent into the suspended liposome-astaxanthin in the step S2, continuing ultrasonic homogenization, and drying to obtain powdery liposome astaxanthin;
and S4, adding the powdery liposome astaxanthin in the step S3 into grease, adding a surfactant, and homogenizing and mixing to obtain the astaxanthin composition.
5. The method of claim 4, wherein in the step S1, the parameters of homogenization are: the temperature is 40-55deg.C, the ultrasonic frequency is 2500-4500Hz, and the homogenizing time is 5-8min.
6. The method of claim 4, wherein in the step S2, the parameters of homogenization are: the temperature is 30-35 ℃, the ultrasonic frequency is 5000-7500Hz, and the homogenizing time is 5-8min.
7. The method of claim 4, wherein the homogenizing time in step S3 is 5-10min.
8. The method of claim 4, wherein the drying temperature in step S3 is 60-65deg.C and the drying time is 30-50min.
9. Use of an astaxanthin composition according to any one of claims 1-3 in a puffed feed, wherein the astaxanthin composition is present in the puffed feed in a mass percentage of 0.5% -1%.
10. Use of an astaxanthin composition according to claim 9 in a puffed feed, wherein said astaxanthin composition is sprayed onto the surface of the puffed feed using post-spraying equipment.
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| JPH06269250A (en) * | 1993-03-18 | 1994-09-27 | Kanegafuchi Chem Ind Co Ltd | Feed pellet for pisciculture |
| WO2009027499A2 (en) * | 2007-08-31 | 2009-03-05 | Basf Se | Method for producing oil-containing solutions of astaxanthin derivatives |
| CN110353100A (en) * | 2019-07-03 | 2019-10-22 | 广州市博仕奥生物科技有限公司 | Composite feed additive and its preparation method and application is sprayed after a kind of feed |
| CN110558435A (en) * | 2019-09-30 | 2019-12-13 | 广东海洋大学 | Astaxanthin nano liposome and preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06269250A (en) * | 1993-03-18 | 1994-09-27 | Kanegafuchi Chem Ind Co Ltd | Feed pellet for pisciculture |
| WO2009027499A2 (en) * | 2007-08-31 | 2009-03-05 | Basf Se | Method for producing oil-containing solutions of astaxanthin derivatives |
| CN110353100A (en) * | 2019-07-03 | 2019-10-22 | 广州市博仕奥生物科技有限公司 | Composite feed additive and its preparation method and application is sprayed after a kind of feed |
| CN110558435A (en) * | 2019-09-30 | 2019-12-13 | 广东海洋大学 | Astaxanthin nano liposome and preparation method and application thereof |
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