CN117500525A - pH调节的抗坏血酸溶液的制备 - Google Patents

pH调节的抗坏血酸溶液的制备 Download PDF

Info

Publication number
CN117500525A
CN117500525A CN202280043073.1A CN202280043073A CN117500525A CN 117500525 A CN117500525 A CN 117500525A CN 202280043073 A CN202280043073 A CN 202280043073A CN 117500525 A CN117500525 A CN 117500525A
Authority
CN
China
Prior art keywords
ascorbic acid
solution
pharmaceutically acceptable
radiolabeled compound
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202280043073.1A
Other languages
English (en)
Chinese (zh)
Inventor
G·麦克罗比
T·恩格尔
K·维克内
I·A·可汗
J·格里格
A·杰克逊
A·克拉克
J·谢尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN117500525A publication Critical patent/CN117500525A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/121—Solutions, i.e. homogeneous liquid formulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN202280043073.1A 2021-06-16 2022-06-16 pH调节的抗坏血酸溶液的制备 Pending CN117500525A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB2108608.7A GB202108608D0 (en) 2021-06-16 2021-06-16 Preparation of a ph-adjusted ascorbic acid solution
GB2108608.7 2021-06-16
PCT/EP2022/066481 WO2022263592A1 (en) 2021-06-16 2022-06-16 Preparation of a ph-adjusted ascorbic acid solution

Publications (1)

Publication Number Publication Date
CN117500525A true CN117500525A (zh) 2024-02-02

Family

ID=76954449

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280043073.1A Pending CN117500525A (zh) 2021-06-16 2022-06-16 pH调节的抗坏血酸溶液的制备

Country Status (6)

Country Link
US (1) US20240350683A1 (enExample)
EP (1) EP4355368A1 (enExample)
JP (1) JP2024523884A (enExample)
CN (1) CN117500525A (enExample)
GB (1) GB202108608D0 (enExample)
WO (1) WO2022263592A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201915206D0 (en) 2019-10-21 2019-12-04 Ge Healthcare Ltd Use of cyclodextrins as a radiostabilizer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0520527D0 (en) 2005-10-10 2005-11-16 Ge Healthcare Ltd Automated method
KR20160030589A (ko) * 2009-04-15 2016-03-18 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
DK3323810T3 (da) 2010-02-08 2022-03-28 Lantheus Medical Imaging Inc Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler
GB201915206D0 (en) * 2019-10-21 2019-12-04 Ge Healthcare Ltd Use of cyclodextrins as a radiostabilizer

Also Published As

Publication number Publication date
GB202108608D0 (en) 2021-07-28
EP4355368A1 (en) 2024-04-24
US20240350683A1 (en) 2024-10-24
JP2024523884A (ja) 2024-07-02
WO2022263592A1 (en) 2022-12-22

Similar Documents

Publication Publication Date Title
AU2018447938B2 (en) Methods for synthesis of radionuclide complex
US10584078B2 (en) Dual run cassette for the synthesis of 18F-labelled compounds
KR101479690B1 (ko) 카트리지를 이용한 방사성의약품 제조방법
CN100478035C (zh) 用18-f标记的放射性药物的稳定化
US20090155167A1 (en) Automated method
ES2953377T3 (es) Disposición de captación de fluoruro
US8968701B2 (en) Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
CN117500525A (zh) pH调节的抗坏血酸溶液的制备
US10662125B2 (en) PET tracer purification system
Loc'h et al. Preparation of [76Br] FLB 457 and [76Br] FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET
KR20240146015A (ko) 방사성 핵종 복합체의 대규모 합성 방법
CA3223802A1 (en) Method for preparing an [18f] radiolabelled compound with low water content during labelling step
EP1968651B1 (en) Stabilized compositions and methods for radiolabeling pharmaceuticals with alpha-particle emitters
CN110582494A (zh) 碘氟潘的制造方法
EP1919517B1 (en) Radiolabelled nanoparticles
Neves et al. Neutral technetium (II)-99m complexes as potential brain perfusion imaging agents
EP4559890A1 (en) Stabilized method for 18f-labeling
WO2025114063A1 (en) Stabilized method for 18f-labeling
HK40076192A (en) Use of cyclodextrins as a radiostabilizer
Eerselsa et al. Manufacturing of I-123-labelled radiopharmaceuticals
GB2231267A (en) Radiopharmaceutical compositions

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination