CN117481910A - Nano silver antibacterial band-aid - Google Patents
Nano silver antibacterial band-aid Download PDFInfo
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- CN117481910A CN117481910A CN202311205671.7A CN202311205671A CN117481910A CN 117481910 A CN117481910 A CN 117481910A CN 202311205671 A CN202311205671 A CN 202311205671A CN 117481910 A CN117481910 A CN 117481910A
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- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 81
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 239000010410 layer Substances 0.000 claims abstract description 98
- 239000003814 drug Substances 0.000 claims abstract description 40
- 239000000463 material Substances 0.000 claims abstract description 31
- 239000012790 adhesive layer Substances 0.000 claims abstract description 27
- 230000001070 adhesive effect Effects 0.000 claims abstract description 16
- 239000000853 adhesive Substances 0.000 claims abstract description 15
- 229940079593 drug Drugs 0.000 claims abstract description 9
- 239000000203 mixture Substances 0.000 claims description 45
- 239000007864 aqueous solution Substances 0.000 claims description 38
- FJOLTQXXWSRAIX-UHFFFAOYSA-K silver phosphate Chemical compound [Ag+].[Ag+].[Ag+].[O-]P([O-])([O-])=O FJOLTQXXWSRAIX-UHFFFAOYSA-K 0.000 claims description 24
- 229940019931 silver phosphate Drugs 0.000 claims description 24
- 229910000161 silver phosphate Inorganic materials 0.000 claims description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 21
- 239000006260 foam Substances 0.000 claims description 19
- 238000001035 drying Methods 0.000 claims description 18
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 16
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 14
- 238000003825 pressing Methods 0.000 claims description 13
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- 238000002156 mixing Methods 0.000 claims description 12
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- 238000006243 chemical reaction Methods 0.000 claims description 9
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- 229960000686 benzalkonium chloride Drugs 0.000 claims description 8
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 8
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 8
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 8
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 7
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- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000006116 polymerization reaction Methods 0.000 claims description 7
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 7
- 239000003381 stabilizer Substances 0.000 claims description 7
- 229910000166 zirconium phosphate Inorganic materials 0.000 claims description 7
- LEHFSLREWWMLPU-UHFFFAOYSA-B zirconium(4+);tetraphosphate Chemical compound [Zr+4].[Zr+4].[Zr+4].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O LEHFSLREWWMLPU-UHFFFAOYSA-B 0.000 claims description 7
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- ANCHPZQGZBCDBK-UHFFFAOYSA-N [PH2](O)=O.C1(=CC=CC=C1)C=1C(=C(C(=O)[Li])C(=CC1C)C)C Chemical group [PH2](O)=O.C1(=CC=CC=C1)C=1C(=C(C(=O)[Li])C(=CC1C)C)C ANCHPZQGZBCDBK-UHFFFAOYSA-N 0.000 claims description 4
- 238000009423 ventilation Methods 0.000 claims description 4
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000000499 gel Substances 0.000 description 65
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- 238000000034 method Methods 0.000 description 7
- 239000011148 porous material Substances 0.000 description 7
- 239000003292 glue Substances 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
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- 230000029663 wound healing Effects 0.000 description 6
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- JUYQFRXNMVWASF-UHFFFAOYSA-M lithium;phenyl-(2,4,6-trimethylbenzoyl)phosphinate Chemical compound [Li+].CC1=CC(C)=CC(C)=C1C(=O)P([O-])(=O)C1=CC=CC=C1 JUYQFRXNMVWASF-UHFFFAOYSA-M 0.000 description 3
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- HCLJOFJIQIJXHS-UHFFFAOYSA-N 2-[2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOCCOCCOC(=O)C=C HCLJOFJIQIJXHS-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 239000002250 absorbent Substances 0.000 description 2
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- 230000001580 bacterial effect Effects 0.000 description 2
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- 210000000416 exudates and transudate Anatomy 0.000 description 2
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- 239000011325 microbead Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- -1 silver ions Chemical class 0.000 description 2
- 238000009864 tensile test Methods 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
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- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The utility model relates to the technical field of medicines, and provides a nano-silver antibacterial band-aid which comprises a base material, an adhesive layer, a water-absorbing antibacterial layer and a medicine layer, wherein an adhesive is uniformly coated on one surface of the base material to form the adhesive layer, the adhesive layer is provided with a groove, the water-absorbing antibacterial layer and the medicine layer are sequentially arranged in the groove from the adhesive layer, and the water-absorbing antibacterial layer consists of a flexible gel sheet and nano-silver.
Description
Technical Field
The utility model relates to the technical field of medicines, in particular to a nano-silver antibacterial band-aid.
Background
The woundplast is a surgical medicine commonly used in daily life, is mostly used for treating smaller wounds, has the effects of stopping bleeding rapidly, protecting wound surfaces, preventing infection and promoting wound healing, mainly comprises rubberized fabric, a water absorption layer and an isolation layer, and is also added with a medicine layer to help the wound healing, and the part of the woundplast, which is in direct contact with the wound, is the water absorption layer, but because the water absorption layer does not have an antibacterial effect, part of the woundplast is added with antibacterial substances in the water absorption layer to enable the woundplast to achieve the antibacterial effect.
The nano silver is a metal silver simple substance with the particle size of nano, generally has the particle size of about 25 nanometers, has strong inhibition and killing effects on dozens of pathogenic bacteria such as escherichia coli, gonococcus and trachoma chlamydia, has good antibacterial property, can not generate drug resistance and any toxic reaction, can not generate stimulation reaction on skin, and can effectively promote wound healing, cell growth and damaged cell repair.
The Chinese patent No. CN204971864U proposes a nanometer silver antibacterial band-aid, including ventilative glue cloth layer, adhesive layer, cotton yarn layer and isolation protection film, the adhesive layer is located the upper surface of ventilative glue cloth layer, the intermediate position of adhesive layer upper surface is provided with cotton yarn layer, isolation protection film then pastes the both ends of adhesive layer upper surface and extends to the centre, and alternately covers on cotton yarn layer from top to bottom, the nanometer silver cotton layer that is used for inhibiting bacteria breeding has been placed between adhesive layer and the cotton yarn layer, the nanometer silver cotton layer extends to cotton yarn layer and has a plurality of nanometer silver cotton layer branches, and still is provided with a bamboo charcoal fiber layer between nanometer silver cotton layer and the adhesive layer, and it has the face yarn layer of nanometer silver, lets the band-aid have antibacterial effect, but its absorbent layer that absorbs the exudation adopts cotton yarn, and cotton yarn is common water absorbing material, but its water absorbing capacity is limited to cotton yarn is difficult to produce with the wound after absorbing water and not only influence the isolation yarn, also can not influence hemostatic effect.
The chinese patent No. CN103394113B proposes a band-aid, which uses at least partially dehydrated bio-cellulose hydrogel as a water absorbing pad, the water content of the at least partially dehydrated bio-cellulose hydrogel is lower than 40%, more preferably, the at least partially dehydrated bio-cellulose hydrogel is dried to a constant weight, as the water absorbing pad, in which the water absorbing layer uses the bio-cellulose hydrogel as the water absorbing pad, the bio-cellulose is milky white, has high water holding capacity and good water absorbing property, and is widely applied to the treatment of medical wound surface, but the band-aid is generally used as an emergency treatment, and the band-aid is stored for a long time, and the hydrogel is gradually dried and dehydrated for a long time, so that the loss of flexibility becomes a solid with higher hardness, and the band-aid is required to have sufficient softness, so that the band-aid of the hydrogel is not suitable for being prepared at home, and similar to diapers, in which the hydrogel is made into microbeads with small particle sizes and is clamped in diaper fabrics, so as to solve the long-time storage problem, but the method has certain thickness, and the problem that the band-aid is not suitable for being stored on the band-aid, but the existing technique has a certain flexibility.
Disclosure of Invention
The utility model aims to provide the nano-silver antibacterial band-aid, which can enable the band-aid to be soft like fabric and have the general water absorption capacity of hydrogel, solves the problem that the hydrogel cannot have flexibility due to brittleness and hardness after being dried, and simultaneously enables the band-aid to have good antibacterial capacity and promote wound healing due to the fact that the nano-silver particles are contained in the flexible gel piece.
In order to solve the technical problems, the technical scheme adopted by the application is as follows:
the embodiment of the application provides a nano-silver antibacterial band-aid, which comprises a base material, an adhesive layer, a water-absorbing antibacterial layer and a medicine layer, wherein adhesive is uniformly coated on one surface of the base material to form the adhesive layer, the adhesive layer is provided with a groove, and the water-absorbing antibacterial layer and the medicine layer are sequentially arranged in the groove from the adhesive layer; the preparation steps of the water-absorbing antibacterial layer are as follows: s1, preparing a flexible gel sheet: (1) preparing a mixture A and a mixture B, wherein the mixture A comprises 15-18% of acrylic acid, 5-8% of acrylamide, 0.3-0.6% of a cross-linking agent and 0.5-0.6% of a polymerization stabilizerAnd 75-78% acetic acid; the mixture B consists of 0.2-0.3% of photoinitiator and 99.7-99.8% of sodium bicarbonate solution in percentage by weight; (2) mixing the mixture A with the mixture B to obtain a foam mixture C, and carrying out the following reaction: R-COOH+NaHCO 3 →R-COONa+CO 2 (g)+H 2 O; (3) filling the foam mixture C into bags, and pressing the bags into sheets by using a pressing machine; (4) irradiating with ultraviolet rays for 2min; (5) taking out from the bag, and soaking in a mixed solution composed of 15-20% glycerol and 80-85% ethanol for 20-30min; (6) taking out and drying at normal temperature to obtain a flexible gel sheet; s2, preparing a silver phosphate aqueous solution; s3, soaking the flexible gel sheet in silver phosphate aqueous solution for 30-50min, taking out and drying; and S4, installing a medical PE film on one surface of the dried flexible gel sheet close to the base material to obtain the water-absorbing antibacterial layer.
The adhesive layer and the medicine layer are consistent with the prior art, and are different in that the water absorption layer uses a flexible gel sheet which is different from the prior art, nano silver is added on the basis of the water absorption layer to increase the antibacterial effect, the water absorption materials commonly used in the prior art are textile fabrics and hydrogels, the textile fabrics are woven by natural fibers or synthetic fibers and are usually provided with porous structures, and can absorb water through capillary action, and the adhesive layer has soft and foldable characteristics, so that the adhesive layer becomes the most commonly used water absorption material of the adhesive bandage, but the water absorption capacity of the textile fabrics is limited, and the expansion coefficient after water absorption is small, so that the adhesive bandage is often insufficient in absorbing wound exudates after being used, loose to be used after a long time, needs to be frequently replaced, and also is used for increasing the water absorption effect and the expansion coefficient of the adhesive bandage, in the prior art, hydrogel is used as a water absorbing material, the hydrogel is usually a super-absorbent polymer and has super-high water holding capacity and water absorbing capacity, but when the hydrogel is dehydrated and dried, solids with certain hardness are formed, when the hydrogel is made into a gel sheet, the hydrogel sheet does not have bending capacity, the hydrogel sheet is quite fragile after being dried, and can not be broken due to bending, the characteristics are not suitable for a band-aid, the band-aid needs to have certain flexibility and bending property, so the medical external application product using the hydrogel at present can keep the hydrogel to have the minimum water content of 40 percent and has certain flexibility, but the hydrogel sheet has thicker thickness when the water content is higher than 40 percent, the thickness is obviously not suitable for the band-aid, and the band-aid is often stored for a long time for standby, in this case, it is difficult to ensure that the hydrogel is moisturized and not dried, and therefore needs to be checked periodically and replaced in time, which clearly increases the cost of use, and in the prior art, there are also used fine particles having a small particle diameter by drying the hydrogel, such as diapers, which are provided with interlayers between fabrics and are filled with a certain number of hydrogel microbeads, so that the hydrogel has high water absorbability and can be provided with a bending capability, but because of the interlayer, the method has a certain thickness, and although it is feasible on the diaper, it is not suitable for a band-aid.
Therefore, in order to thoroughly solve the defect that the hydrogel is applied to the band-aid, the flexible gel sheet is creatively manufactured, the high water absorption capacity of the hydrogel is maintained, the flexible gel sheet can also be provided with flexibility like fabrics after drying, in order to achieve the effect, the monomer polymer with stable foam needs to be produced firstly, the porous structure of the material is achieved, the acrylic acid monomer and the non-monomer acrylamide are used in the method, acetic acid, a cross-linking agent and a polymerization stabilizer are added, sodium bicarbonate and a photoinitiator are added in the other reactant, after two mixtures are contacted, ethylene and the sodium bicarbonate react to generate carbon dioxide, the foam is formed in the monomer polymer, the polymerization stabilizer is adsorbed on the foam, so as to stabilize the foam, the mixture is placed in a bag and compressed into a sheet shape, ultraviolet irradiation is used after compression, the shape can be fixed, the polymer network can be formed around the foam due to the action of the polymerization stabilizer, the integrity of the foam is ensured, the foam can be kept in the film after the compression by using a pressing plate, the polymer is well-shaped, the glycerin can be placed in a solvent after being bent, the glycerin is well-shaped, and the water absorption film can be well-folded, the water absorption film can be well, and the water absorption film can be kept, and the flexible film can be well folded, and the adhesive sheet can be well dried, and the surface of the adhesive sheet can be folded, and the adhesive film can be well be folded, and the adhesive film can be dried.
In order to enable the water absorption layer to have an antibacterial effect, nano silver is added into the flexible gel sheet, firstly, a silver phosphate aqueous solution is needed to be prepared, the dried flexible gel sheet is soaked into the silver phosphate aqueous solution after the preparation, and due to the porous structure in the flexible gel sheet and the fact that pores are connected with each other to form an open micro-channel network, the channels promote liquid absorption into the flexible gel sheet through capillary action, silver ions enter the pores along with the solution in the process and are adsorbed on the flexible gel sheet, and after the adsorption is completed, the flexible gel sheet is taken out and dried, so that nano silver can be contained in the flexible gel sheet, and the antibacterial effect is achieved.
In some embodiments of the present utility model, the substrate is a medical polyurethane film, and the polyurethane film is also called as a PU film, which has the characteristics of good elasticity and slightly high water resistance, and also has good moisture permeability, so that the band-aid has a waterproof effect, and can discharge sweat of a human body when in use, and the PU film is environment-friendly, nontoxic, recoverable and decomposable, and can be perfectly suitable for the band-aid to be used as a substrate.
In some embodiments of the present utility model, the drug in the drug layer is benzalkonium chloride, which is a cationic surfactant, and has high-efficiency and spectral disinfection and sterilization effects, and is mainly used for disinfecting skin, mucous membrane and wounds, and can change permeability of bacterial plasma membrane, so that bacterial plasma substances are exosmosis, and metabolism is blocked to play a role in killing.
In some embodiments of the present utility model, the cross-linking agent is polyethylene glycol diacrylate, wherein polyethylene glycol diacrylate is used in the cross-linking agent, and the optimal concentration is 0.5-0.6% of the total mixture A, so that the gel sheet has good flexibility, if the concentration of polyethylene glycol diacrylate is too low, the dried gel sheet is sticky, the internal pores of the gel sheet collapse,
if the concentration of the polyethylene glycol diacrylate is too high, the dried gel sheet loses softness and hardens, the water absorption capacity of the gel sheet is reduced, and meanwhile, the inventor adopts short-chain cross-linking agents such as tetraethylene glycol diacrylate, but the cross-linking agents only shrink to 50-60% of the original volume after the gel sheet is dried, and when the polyethylene glycol diacrylate is used, the volume after drying can shrink to 10-15% of the original volume, so that the polyethylene glycol diacrylate can prove that the polyethylene glycol diacrylate can ensure the integrity of pores in the gel sheet, and the gel sheet can also generate flexibility like a fabric.
In some embodiments of the present utility model, the polymeric stabilizer is a hydrophobic modified chitosan, the hydrophobic modified chitosan can keep the gel sheet with good strength after absorbing water, at present, a part of hydrogel can lose the connection strength after absorbing excessive water, the hydrogel can not be lifted by hands, the hydrophobic modified chitosan is adsorbed on generated bubbles to form a pore network, the connection strength between the hydrophobic modified chitosan and the generated bubbles is increased, the gel sheet after absorbing water can have certain strength when guaranteeing the integrity of the bubbles, and meanwhile, the hydrophobic modified chitosan can keep the bubbles stable when being irradiated by an ultraviolet lamp, so that the gel sheet has a highly porous structure and interconnected gaps, and can not loose and collapse after ultraviolet irradiation shaping.
In some embodiments of the present utility model, the photoinitiator is phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate, the phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate is a photoinitiator, which can initiate chemical reaction under irradiation of ultraviolet light or blue light, absorb light energy under irradiation to make molecules of the photoinitiator generate excited states, thereby causing chemical reaction, wherein the excited state free radicals of the phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate can initiate polymerization reaction and crosslinking reaction, the free radicals react with monomer molecules to form a larger polymer, and the excited state free radicals react with two monomer molecules to form a crosslinking structure in the crosslinking reaction, so that the mixture A and the mixture B are fully fused to form a whole, and the required sheet shape is achieved after connection, and the crosslinking strength is good.
In some embodiments of the present utility model, the preparation steps of the silver phosphate aqueous solution are: mixing zirconium phosphate aqueous solution and silver nitrate aqueous solution in a ratio of 1:1, heating at 60-80 ℃ to obtain silver phosphate aqueous solution, preparing silver ion-containing solution in order to enable the water-absorbing antibacterial layer to contain nano silver, selecting silver phosphate aqueous solution as a carrier, carrying out displacement reaction between zirconium phosphate aqueous solution and silver nitrate aqueous solution during preparation, heating to 60-80 ℃ to react to speed up reaction, obtaining silver phosphate aqueous solution after reaction, soaking a dried flexible gel sheet in the solution, and enabling silver ions to be adsorbed in the flexible gel sheet well due to pore structures in the flexible gel sheet, so that nano silver can be attached to the flexible gel sheet after drying, thereby having antibacterial effect.
In some embodiments of the present utility model, the base material is further provided with a plurality of ventilation holes arranged at intervals, and the ventilation holes are all located in the middle of the base material, and the base material selects the PU film, so that the band-aid has a waterproof effect, and otherwise, local wounds can be airtight and wound healing is affected.
In some embodiments of the present utility model, the adhesive bandage further comprises two release papers, wherein the two release papers are respectively adhered to two ends of the adhesive layer and extend towards the middle, and are vertically and alternately covered on the medicine layer, the release papers can completely cover the adhesive layer, the adhesive bandage can be easily stored while the adhesive property of the adhesive bandage is maintained, and meanwhile, the release papers are alternately covered on the medicine layer to protect the medicine layer from being polluted, and the adhesive bandage can be torn when in use.
In some embodiments of the present utility model, the thickness of the water-absorbing antimicrobial layer is 800-1200 μm, and since the flexible gel sheet has a higher expansion coefficient after absorbing water, a suitable thickness is required to be selected, and a smaller thickness correspondingly reduces the density of the pore network in the flexible gel sheet, so that the water-absorbing capacity of the flexible gel sheet is reduced, and the thicker thickness can expand too much after absorbing water, so that the compression effect on the wound is too strong, and therefore, the thickness is selected to be 800-1200 μm in combination with the outflow of wound exudates.
Compared with the prior art, the embodiment of the utility model has at least the following advantages or beneficial effects:
1. the flexible gel sheet is used as the water absorbing material, so that the high water holding capacity and water absorbing capacity of the hydrogel material are maintained, the gel sheet has flexibility of the fabric material after drying, and the problem that the fabric material has insufficient water absorbing capacity and has no flexibility after drying in the prior art is solved.
2. The nano silver is added in the flexible gel sheet, so that the band-aid has an antibacterial effect, the effect can be reduced after the band-aid meets blood although the drug layer is provided with benzalkonium chloride, the nano silver has strong antibacterial capability, the defect of benzalkonium chloride can be overcome, wound infection is prevented, and wound healing is accelerated.
3. Because the flexible gel sheet still has textile-like flexibility after being dried, the flexible gel sheet does not need to keep certain water content, the thickness of the adhesive bandage is reduced, the adhesive bandage can be stored for a long time, and the problem of drying failure of the hydrogel adhesive bandage in the prior art is solved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present utility model and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
Fig. 1 is a schematic diagram of the overall structure of the nano-silver antibacterial band-aid provided by the utility model.
Icon: 100-substrate; 200-an adhesive layer; 300-a water-absorbing antibacterial layer; 400-drug layer; 500-release paper.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present utility model more clear, the technical solutions of the embodiments of the present utility model will be clearly and completely described below. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
It should be noted that, without conflict, the embodiments of the present utility model and features of the embodiments may be combined with each other. The present utility model will be described in detail with reference to specific examples.
A nano silver antibacterial band-aid, which comprises the following steps:
s1, using a PU film as a base material, uniformly coating medical maleic glue on the PU film to form a viscose layer, and forming a groove in the middle of the base material;
s2, preparing a medicine layer, wherein the medicine layer is made of cotton cloth, and 0.05-0.1% concentration benzalkonium chloride is smeared on the surface of the medicine layer;
s3, preparing a water-absorbing antibacterial layer:
first, a flexible gel sheet was prepared:
(1) preparing a mixture A consisting of 15-18% of acrylic acid, 5-8% of acrylamide, 0.3-0.6% of a cross-linking agent, 0.5-0.6% of a polymerization stabilizer and 75-78% of acetic acid and a mixture B consisting of 0.2-0.3% of a photoinitiator and 99.7-99.8% of sodium bicarbonate solution in percentage by weight;
(2) thoroughly mixing the mixture A and the mixture B to obtain a foam mixture C;
(3) filling the foam mixture C into bags, and pressing the bags into sheets by using a pressing machine;
(4) irradiating with ultraviolet rays for 2min;
(5) taking out from the bag, and soaking in a mixed solution composed of 15-20% glycerol and 80-85% ethanol for 20-30min;
(6) taking out and drying at normal temperature to obtain a flexible gel sheet;
secondly, preparing a silver phosphate aqueous solution: mixing zirconium phosphate aqueous solution and silver nitrate aqueous solution in a ratio of 1:1, and heating at 60-80 ℃ to obtain silver phosphate aqueous solution;
finally, the flexible gel sheet is placed into silver phosphate aqueous solution to be soaked for 30-50min, and is taken out and dried, and a medical PE film is arranged on the surface of the dried flexible gel sheet to obtain a water-absorbing antibacterial layer;
s4, trimming the water-absorbing antibacterial layer into the size of a groove, installing the water-absorbing antibacterial layer in the groove, and then installing the medicine layer in the groove to attach the water-absorbing antibacterial layer to obtain the nano-silver antibacterial band-aid;
s5, respectively adhering two pieces of release paper to two ends of the adhesive layer, extending towards the middle part, and covering the medicine layers in a crossing manner.
The features and capabilities of the present utility model are described in further detail below in connection with the examples.
Example 1
S1, using a PU film as a base material, uniformly coating medical maleic glue on the PU film to form a viscose layer, and forming a groove in the middle of the base material;
s2, preparing a medicine layer, wherein the medicine layer is made of cotton cloth, and benzalkonium chloride with the concentration of 0.05% is smeared on the surface of the medicine layer;
s3, preparing a water-absorbing antibacterial layer:
first, a flexible gel sheet was prepared:
(1) preparing a mixture A consisting of 16% acrylic acid, 6% acrylamide, 0.3% polyethylene glycol diacrylate, 0.5% hydrophobically modified chitosan and 77.2% acetic acid by weight and a mixture B consisting of 0.2% lithium phenyl-2, 4, 6-trimethylbenzoyl phosphinate by weight and 99.8% sodium bicarbonate solution by weight;
(2) thoroughly mixing the mixture A and the mixture B to obtain a foam mixture C;
(3) filling the foam mixture C into bags, and pressing the bags into sheets by using a pressing machine;
(4) irradiating with ultraviolet rays for 2min;
(5) taking out from the bag, and soaking in a mixed solution consisting of 15% glycerol and 85% ethanol by volume fraction for 30min;
(6) taking out and drying at normal temperature to obtain a flexible gel sheet;
secondly, preparing a silver phosphate aqueous solution: mixing zirconium phosphate aqueous solution and silver nitrate aqueous solution in a ratio of 1:1, and heating at 60 ℃ to obtain silver phosphate aqueous solution;
finally, the flexible gel sheet is placed into silver phosphate aqueous solution to be soaked for 50min, and is taken out to be dried, and a medical PE film is arranged on the surface of the dried flexible gel sheet to obtain a water-absorbing antibacterial layer;
s4, trimming the water-absorbing antibacterial layer into the size of a groove, installing the water-absorbing antibacterial layer in the groove, and then installing the medicine layer in the groove to attach the water-absorbing antibacterial layer to obtain the nano-silver antibacterial band-aid;
s5, respectively adhering two pieces of release paper to two ends of the adhesive layer, extending towards the middle part, and covering the medicine layers in a crossing manner.
Example 2
S1, using a PU film as a base material, uniformly coating medical maleic glue on the PU film to form a viscose layer, and forming a groove in the middle of the base material;
s2, preparing a medicine layer, wherein the medicine layer is made of cotton cloth, and 0.1% concentration benzalkonium chloride is smeared on the surface of the medicine layer;
s3, preparing a water-absorbing antibacterial layer:
first, a flexible gel sheet was prepared:
(1) preparing a mixture A consisting of 16% acrylic acid, 7% acrylamide, 0.6% polyethylene glycol diacrylate, 0.6% hydrophobically modified chitosan and 75.8% acetic acid by weight and a mixture B consisting of 0.3% lithium phenyl-2, 4, 6-trimethylbenzoyl phosphinate and 99.7% sodium bicarbonate solution by weight;
(2) thoroughly mixing the mixture A and the mixture B to obtain a foam mixture C;
(3) filling the foam mixture C into bags, and pressing the bags into sheets by using a pressing machine;
(4) irradiating with ultraviolet rays for 2min;
(5) taking out from the bag, and soaking in a mixed solution consisting of 20% glycerol and 80% ethanol by volume fraction for 20min;
(6) taking out and drying at normal temperature to obtain a flexible gel sheet;
secondly, preparing a silver phosphate aqueous solution: mixing zirconium phosphate aqueous solution and silver nitrate aqueous solution in a ratio of 1:1, and heating at 80 ℃ to obtain silver phosphate aqueous solution;
finally, the flexible gel sheet is placed into silver phosphate aqueous solution to be soaked for 30min, and is taken out to be dried, and a medical PE film is arranged on the surface of the dried flexible gel sheet to obtain a water-absorbing antibacterial layer;
s4, trimming the water-absorbing antibacterial layer into the size of a groove, installing the water-absorbing antibacterial layer in the groove, and then installing the medicine layer in the groove to attach the water-absorbing antibacterial layer to obtain the nano-silver antibacterial band-aid;
s5, respectively adhering two pieces of release paper to two ends of the adhesive layer, extending towards the middle part, and covering the medicine layers in a crossing manner.
Example 3
S1, using a PU film as a base material, uniformly coating medical maleic glue on the PU film to form a viscose layer, and forming a groove in the middle of the base material;
s2, preparing a medicine layer, wherein the medicine layer is made of cotton cloth, and 0.08% concentration benzalkonium chloride is smeared on the surface of the medicine layer;
s3, preparing a water-absorbing antibacterial layer:
first, a flexible gel sheet was prepared:
(1) preparing a mixture A consisting of 16.5% acrylic acid, 6.5% acrylamide, 0.49% polyethylene glycol diacrylate, 0.56% hydrophobically modified chitosan and 75.95% acetic acid by weight and a mixture B consisting of 0.24% lithium phenyl-2, 4, 6-trimethylbenzoyl phosphinate by weight and 99.76% sodium bicarbonate solution by weight;
(2) thoroughly mixing the mixture A and the mixture B to obtain a foam mixture C;
(3) filling the foam mixture C into bags, and pressing the bags into sheets by using a pressing machine;
(4) irradiating with ultraviolet rays for 2min;
(5) taking out from the bag, and soaking in a mixed solution consisting of 15% glycerol and 85% ethanol by volume fraction for 25min;
(6) taking out and drying at normal temperature to obtain a flexible gel sheet;
secondly, preparing a silver phosphate aqueous solution: mixing zirconium phosphate aqueous solution and silver nitrate aqueous solution in a ratio of 1:1, and heating at 70 ℃ to obtain silver phosphate aqueous solution;
finally, the flexible gel sheet is placed into silver phosphate aqueous solution to be soaked for 40min, and is taken out to be dried, and a medical PE film is arranged on the surface of the dried flexible gel sheet to obtain a water-absorbing antibacterial layer;
s4, trimming the water-absorbing antibacterial layer into the size of a groove, installing the water-absorbing antibacterial layer in the groove, and then installing the medicine layer in the groove to attach the water-absorbing antibacterial layer to obtain the nano-silver antibacterial band-aid;
s5, respectively adhering two pieces of release paper to two ends of the adhesive layer, extending towards the middle part, and covering the medicine layers in a crossing manner.
Comparative example 1
This comparative example 1 was substantially the same as example 3 except that the water-absorbing antibacterial layer was replaced with a common medical cotton cloth.
To verify the water absorption and antibacterial ability of the present utility model, tests were performed with the embodiments of examples 1 to 3 and comparative example 1, and tables 1 and 2 are test data of examples 1 to 3 and comparative example 1, and the test results are as follows:
the water absorption test is carried out by adopting a screen mesh method, and the specific method is as follows: the flexible gel sheets prepared in examples 1-3 were removed, the medical cotton cloth in comparative example 1 was removed, and after weighing, it was put into pure water to fully absorb water and swell, and the water was filtered and weighed, and calculated by the water absorption formula:
water absorption = wet weight-dry weight/dry weight.
TABLE 1
| Water absorption rate | |
| Implementation of the embodimentsExample 1 | 3.597 |
| Example 2 | 3.644 |
| Example 3 | 3.825 |
| Comparative example 1 | 1.739 |
As can be seen from Table 1, the water absorption of examples 1-3 is significantly higher than that of comparative example 1, because the water absorbing materials of examples 1-3 use flexible gel sheets, and comparative example 1 is medical cotton cloth, it can be demonstrated that the water absorbing effect of the flexible gel sheets is significantly higher than that of the common medical cotton cloth, and the water absorbing capacity of the hydrogel materials is provided.
The antibacterial effect of the prepared nano silver antibacterial adhesive tape is tested by adopting a testing method in an antibacterial (anti-bacterial) test in 2002 edition of disinfection technical Specification, 2.1.
TABLE 2
| Staphylococcus aureus inhibition zone (mm) | Coliform bacteria inhibition zone (mm) | |
| Example 1 | 16 | 14 |
| Example 2 | 17 | 16 |
| Example 3 | 19 | 18 |
| Comparative example 1 | 3 | 3 |
As can be seen from Table 2, the antibacterial effect of the nano silver antibacterial band-aid with nano silver is obviously better than that of the common medical cotton cloth, and meanwhile, the antibacterial effect of the embodiment 3 is optimal, so that the nano silver has antibacterial capability, and the antibacterial capability is very good, and the nano silver antibacterial band-aid can be suitable for the band-aid.
Comparative example 2
This comparative example 2 is substantially the same as example 3 except that the water-absorbing antibacterial layer is replaced with a bio-cellulose hydrogel.
To verify that the flexible gel sheets had textile-like flexibility after drying, tests were performed using the embodiments of examples 1-3 and comparative example 2, two flexible gel sheets were prepared, one for each and two biocellulose hydrogels were prepared, one for each, the flexible gel sheets and the biocellulose hydrogels were vacuum dried to constant weight at 60 ℃, and the flexible gel sheets were cut into two wide, middle narrow shapes, total length 40mm, narrow zone width 20mm, thickness 5mm, the biocellulose hydrogels were as above, the two flexible gel sheets and the biocellulose hydrogels were divided into two groups, and one group was subjected to tensile test: clamping two ends of a flexible gel sheet and two ends of a biological cellulose hydrogel, stretching at a constant speed of 2mm/min, and testing under the conditions that the tensile strength is 2kPa and the tensile modulus is 4.8 kPa; the other group was subjected to compression test: compression was performed at a compression rate of 50 μm/s, and the test was performed at a compression rate, and the recovery of the compressed material was observed, and the test results are shown in Table 3:
compression ratio = (thickness before compression-thickness after compression/thickness before compression) ×100%
TABLE 3 Table 3
As can be seen from table 3, the flexible gel sheet has good flexibility and tensile strength after drying, and can be compressed by 85% at maximum, and is restored to the original state immediately after stopping compression, and no damage or deformation occurs, so it can be confirmed that it has flexibility of textile-like material, whereas the bio-cellulose hydrogel forms a relatively brittle solid after drying, so it breaks after stretching by only 2mm in tensile test, and it is not possible to perform subsequent test by direct breaking in compression test, so it does not have flexibility of textile-like material when it is dried.
The above is only a preferred embodiment of the present utility model, and is not intended to limit the present utility model, but various modifications and variations can be made to the present utility model by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present utility model should be included in the protection scope of the present utility model.
Claims (10)
1. A nano-silver antibacterial band-aid, which is characterized by comprising: the adhesive is uniformly coated on one surface of the base material to form an adhesive layer, the adhesive layer is provided with a groove, and a water-absorbing antibacterial layer and a drug layer are sequentially arranged in the groove; the preparation steps of the water-absorbing antibacterial layer are as follows:
s1, preparing a flexible gel sheet:
(1) preparing a mixture A and a mixture B, wherein the mixture A comprises, by weight, 15-18% of acrylic acid, 5-8% of acrylamide, 0.3-0.6% of a cross-linking agent, 0.5-0.6% of a polymerization stabilizer and 75-78% of acetic acid; the mixture B comprises 0.2-0.3% of photoinitiator and 99.7-99.8% of sodium bicarbonate solution by weight percent;
(2) mixing the mixture A with the mixture B to obtain a foam mixture C, and carrying out the following reaction:
R-COOH+NaHCO 3 →R-COONa+CO 2 (g)+H 2 O；
(3) filling the foam mixture C into bags, and pressing the bags into sheets by using a pressing machine;
(4) irradiating with ultraviolet ray for 2min;
(5) taking out from the bag, and soaking in a mixed solution of 15-20% glycerol and 80-85% ethanol for 20-30min;
(6) taking out and drying at normal temperature to obtain a flexible gel sheet;
s2, preparing a silver phosphate aqueous solution;
s3, soaking the flexible gel sheet in silver phosphate aqueous solution for 30-50min, taking out and drying;
and S4, installing a medical PE film on one surface of the dried flexible gel sheet close to the base material to obtain the water-absorbing antibacterial layer.
2. The nano-silver antibacterial band-aid according to claim 1, wherein the base material is a medical polyurethane film.
3. The nano-silver antibacterial band-aid according to claim 1, wherein the drug in the drug layer is benzalkonium chloride.
4. The nano-silver antibacterial band-aid according to claim 1, wherein the cross-linking agent is polyethylene glycol diacrylate.
5. The nano-silver antibacterial band-aid according to claim 1, wherein the polymeric stabilizer is hydrophobically modified chitosan.
6. The nano-silver antibacterial band-aid according to claim 1, wherein the photoinitiator is phenyl-2, 4, 6-trimethylbenzoyl lithium phosphinate.
7. The nano-silver antibacterial band-aid according to claim 1, wherein the preparation steps of the silver phosphate aqueous solution are as follows: mixing the zirconium phosphate aqueous solution and the silver nitrate aqueous solution in a ratio of 1:1, and heating at 60-80 ℃ to obtain the silver phosphate aqueous solution.
8. The nano-silver antibacterial band-aid according to claim 1, wherein a plurality of ventilation holes are formed in the base material at intervals, and the ventilation holes are formed in the middle of the base material.
9. The nano-silver antibacterial band-aid according to claim 1, further comprising two pieces of release paper, wherein the two pieces of release paper are respectively adhered to two ends of the adhesive layer and extend towards the middle, and are vertically and crosswise covered on the medicine layer.
10. The nano-silver antibacterial band-aid according to claim 1, wherein the thickness of the water-absorbing antibacterial layer is 800-1200 μm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311205671.7A CN117481910A (en) | 2023-09-18 | 2023-09-18 | Nano silver antibacterial band-aid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311205671.7A CN117481910A (en) | 2023-09-18 | 2023-09-18 | Nano silver antibacterial band-aid |
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| CN117481910A true CN117481910A (en) | 2024-02-02 |
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| CN202311205671.7A Pending CN117481910A (en) | 2023-09-18 | 2023-09-18 | Nano silver antibacterial band-aid |
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