CN110025815B - Silver ion dressing used after anorectal operation and gynecological operation and preparation method thereof - Google Patents
Silver ion dressing used after anorectal operation and gynecological operation and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention belongs to the technical field of sensory control medical dressings, and particularly relates to a silver ion dressing used after anorectal surgery and gynecological surgery and a preparation method thereof. The silver ion dressing provided by the invention comprises a functional layer, a water absorption layer, an adhesive layer and release paper, wherein the functional layer comprises silver ions and medical cotton base cloth, and the water absorption layer comprises cotton fibers, starch grafted acrylate polymers and chitosan fibers. The silver ion dressing prepared by the invention has the advantages of obvious moisture absorption and preservation effects and good wound protection, antibiosis and infiltration absorption effects, can effectively promote wound healing, and is particularly suitable for anorectal operations such as: TST postoperative, anal fistula postoperative, perianal abscess postoperative, hemorrhoid postoperative and gynecological operation as follows: the dressing is an ideal moisture-absorbing and antibacterial dressing for antibacterial, suction and infiltration and nursing of wound surfaces after induced abortion, drug abortion, cervix uteri, vagina operation, uterus operation and the like.
Description
Technical Field
The invention belongs to the technical field of sensory control medical dressings, and particularly relates to a silver ion dressing used after anorectal surgery and gynecological surgery and a preparation method thereof.
Background
The medical dressing is a medical material for temporarily covering the surfaces of various wounds and wounds, can prevent the wounds from being affected by bacterial infection and other external factors, and plays a role in protecting the wounds and the wound surfaces. Wound or wound healing is a continuous dynamic process, which is the process of interactions between cells, cells and matrix and soluble media. Modern studies have found that in wet environments wound healing is 2 times faster than in dry environments, but in damp warm environments bacterial growth is also accelerated, especially after gynaecological surgery such as: after induced abortion, after drug abortion, after cervix uteri, after vagina, after uterus, and the like, after anorectal surgery, such as: wounds which are easy to bleed and purulent, such as TST postoperative wounds, anal fistula postoperative wounds, perianal abscess postoperative wounds, hemorrhoid postoperative wounds and the like, are easy to become important sources of cross infection in the affected area.
The traditional dressing mainly utilizes padding, gauze, lining cloth or similar covering materials to protect wounds and wound surfaces, and has the main functions of stopping bleeding, sterilizing and absorbing exudate of the wound surfaces. The effect is not satisfactory, and the traditional dressings are easy to dry after imbibing, are easy to adhere to wounds to cause secondary wounds, damage new tissues during removal and bring great pain to patients; and the gauze gas permeability is strong, and the probability of bacterial infection also can be along with increasing, if wrap thickness too big then lead to the gas permeability poor, need frequently change the dressing.
In order to prevent the postoperative adhesion of patients when the dressings are used after operation, the dressings for preventing postoperative adhesion in different forms such as solution type, gel type or film type have been developed, and some dressings have been clinically used, including anti-adhesion medical dressings in different properties, different materials and different forms such as water solubility, water insolubility, biodegradability and non-degradability, natural polymer type and synthetic polymer type.
Patent document CN107693836A discloses an antibacterial alginate hydrocolloid dressing and a preparation method thereof, wherein the antibacterial alginate hydrocolloid dressing is composed of gelatin, modified sodium alginate, polyethylene glycol, polyethylene and antibacterial peptide D2a 21. The prepared antibacterial alginate hydrogel dressing has the advantages of strong water absorption, excellent performance, good biocompatibility and antibacterial effect.
Patent document CN107875432A discloses a composite nanofiber antibacterial dressing and a preparation method thereof, the composite nanofiber antibacterial dressing is prepared by utilizing the water absorption of polyaspartic acid material, and after polyaspartic acid hydrogel nanofiber is prepared, silver ions are adsorbed and then reduced into nano silver, so that the interference of adding nano silver into a spinning solution to the spinning process can be avoided; the ionic complexation property of the polyaspartic acid is utilized to complex with silver ions firstly, and then the silver ions are reduced into nano silver, so that the agglomeration of nano silver particles can be avoided; the polyaspartic acid hydrogel/nano-silver composite nanofiber antibacterial dressing prepared by combining the advantages of polyaspartic acid materials and the bactericidal property of nano-silver has the advantages of high specific surface area of a nanofiber structure, capability of quickly absorbing liquid, antibacterial effect, simple method and low cost.
However, the current antibacterial moisture absorption dressing has poor moisture absorption effect or has a water absorption layer, but the penetrating fluid can quickly diffuse to other areas in the process of absorbing the liquid, so that the surrounding healthy skin can be damaged due to long-term impregnation by the wound penetrating fluid, and the ideal protection effect cannot be achieved.
Disclosure of Invention
In order to overcome the defects of the antibacterial moisture-absorbing dressing in the prior art, the invention aims to provide a silver ion dressing to solve the defects.
The invention provides a silver ion dressing used after anorectal surgery and gynecological surgery, which comprises a functional layer, a water absorption layer, an adhesive layer and release paper, wherein the functional layer is composed of silver ions and medical cotton base cloth, and the water absorption layer is composed of cotton fibers, starch grafted acrylate polymers and chitosan fibers. The anion is selected from silver sulfate, silver nitrate, silver chloride or zirconium sodium phosphate and the like.
Further, the content of the silver in the functional layer is 0.001-1.00% of the mass of the functional layer.
Further, the water absorption layer comprises the following components in parts by weight:
40-50 parts of cotton fiber, 65-75 parts of starch grafted acrylate polymer and 15-25 parts of chitosan fiber.
Further, the water absorption layer comprises the following components in parts by weight:
45 parts of cotton fiber, 68 parts of starch grafted acrylate polymer and 20 parts of chitosan fiber.
Furthermore, the length of the cotton fiber is 33-40 mm, and the linear density is 1.50-1.20 dtex.
Further, the starch grafted acrylate polymer is a copolymer of starch and acrylamide/acrylic acid. The preparation method of the copolymer of the starch and the acrylamide/acrylic acid is prepared by referring to the synthesis method of the starch binary grafted super absorbent resin in the papers published by Wanjuan and entitled "synthesis and application of starch grafted acrylate polymers".
Further, the chitosan fiber is a hydrophobic chitosan fiber.
Further, the adhesive layer is a polyethylene pressure-sensitive adhesive layer.
Further, the pH value of the silver ion dressing is 4.0-7.0.
In addition, the invention also provides a preparation method of the silver ion dressing, which comprises the following steps:
preparing a water absorption layer by a hot melting mode, compounding a functional layer and the water absorption layer together by the hot melting mode, then adhering the functional layer and the water absorption layer to an adhesive layer, covering release paper outside the adhesive layer, and performing irradiation sterilization, wherein the irradiation sterilization conditions are as follows: and (5) carrying out cobalt 60 gamma ray with the dosage of 25-40 kGy to obtain the product.
Currently, dressings for wound care are required to have high moisture absorption and retention properties, which may be more advantageous for wound healing. The silver ion dressing for anorectal surgery and gynecological surgery comprises a functional layer, a water absorption layer, an adhesive layer and release paper, wherein the functional layer contains 0.001-1.00% of silver ions in mass of the functional layer, so that bacterial growth of wounds can be inhibited, and infection and purulence of the wounds can be prevented; the water absorption layer mainly plays a role in absorbing and preserving moisture, a moist environment is provided for wounds, healing of the wounds is promoted, secondary damage of new tissues can be prevented when dressing is replaced, meanwhile, starch grafted acrylate polymers and cotton fibers in the water absorption layer can quickly absorb penetrating fluid of the wounds, the penetrating fluid of the wounds can be effectively prevented from penetrating into peripheral healthy skin, the healthy skin is prevented from being damaged, in addition, chitosan fibers in the water absorption layer can also effectively prevent the penetrating fluid from spreading, the quick penetrating fluid of the wounds can be promoted, and the quick penetrating fluid flows to the water absorption layer vertically.
The specific principle that the water absorption layer provided by the invention can quickly and vertically absorb the wound penetrating fluid is as follows: the copolymer of starch and acrylamide/acrylic acid adopted by the invention is formed by mutually interpenetration of starch, grafted potassium acrylate and acrylamide straight chain, a developed water-absorbing three-dimensional network structure with holes is formed, a plurality of ionic groups are distributed in the network structure, and the ionic groups can quickly absorb water to enter the three-dimensional network structure, so that the effect of quickly absorbing wound penetrating fluid is achieved, and meanwhile, the absorbed water is fixed in the network, so that a very good moisturizing effect can be achieved. The three-dimensional network structure has elasticity, so that a large number of water molecules can be accommodated, and a good water absorption and moisture preservation effect is achieved. Meanwhile, a certain amount of cotton fiber is added, so that the absorption of wound penetrating fluid can be promoted, the crosslinking density of the starch grafted acrylate polymer can be reduced, the molecular chain of the resin can be further stretched, and the water absorption effect of the copolymer of the starch and the acrylamide/acrylic acid can be further improved. In addition, the addition of a certain amount of chitosan fiber can not only prevent the transverse permeation of wound penetrant and prevent the damage of peripheral healthy skin, but also dredge the network structure of the copolymer of starch and acrylamide/acrylic acid and increase the storage space of water molecules, thereby improving the moisture retention of the copolymer of starch and acrylamide/acrylic acid. Therefore, the water absorption layer provided by the invention can achieve good water absorption and moisture preservation effects under the interaction of the components.
The silver ion dressing for anorectal operation and gynecological operation provided by the invention has good wound protection, antibacterial and infiltration absorption effects, and is particularly suitable for gynecological operation such as: after induced abortion, after drug abortion, after cervix uteri, after vagina, after uterus, and the like, after anorectal surgery, such as: antibacterial, suction and infiltration and nursing of wound surfaces after TST operation, anal fistula operation, perianal abscess operation, hemorrhoid operation and the like. The using method comprises the following steps: before use, the affected part of the skin is cleaned, and then the silver ion dressing with a proper size is selected and lightly applied to the affected part or stuck to the inner side of underpants of a patient, so that the silver-containing dressing core is tightly adhered to the wound surface to achieve the functions of suction, infiltration and antibiosis. The dressing is changed according to the exudation condition of the wound surface.
The silver ion dressing for anorectal surgery and gynecological surgery provided by the invention comprises a functional layer, a water absorption layer, an adhesive layer and release paper: the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 0.01-5 mm, and the gram weight of the prepared functional layer is 1-100 g/square meter; the water absorbing layer comprises the following components in parts by weight: 40-50 parts of cotton fiber, 65-75 parts of starch grafted acrylate polymer and 15-25 parts of chitosan fiber, wherein the length of the cotton fiber is 33-40 mm, the linear density is 1.50-1.20 dtex, the thickness is 1-15 mm, and the gram weight of the prepared water absorbing layer is 8-300 g/square meter; the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness is 0.01 mm-5 mm, and the gram weight of the prepared adhesive layer is 10 g-500 g/square meter; the pH value of the silver ion dressing is 4.0-7.0. The product specification of the invention can be divided into the following specifications according to the size: a silver-containing core: 3cm × 4cm, 5cm × 5cm, 8cm × 8cm, 5cm × 10cm, 5cm × 15cm, 5cm × 20cm, 5cm × 25cm, 6cm × 8cm, 6cm × 15cm, 6cm × 20cm, 6cm × 24cm, 10cm × 10cm, 10cm × 20cm, 15cm × 20cm, and 15cm × 25 cm. The actual side length of the prepared dressing is not less than 90% of the marked side length.
In a word, compared with the prior art, the silver ion dressing for anorectal operation and gynecological operation provided by the invention has the advantages of obvious moisture absorption and moisture retention effects and good wound protection, antibacterial and infiltration effects, can effectively promote wound healing, and is particularly suitable for gynecological operation such as: after induced abortion, after drug abortion, after cervix uteri, after vagina, after uterus, and the like, after anorectal surgery, such as: the wound surface after TST operation, anal fistula operation, perianal abscess operation, hemorrhoid operation and the like is antibacterial and nursing, and the dressing is an ideal moisture-absorbing and antibacterial dressing.
Description of the drawings:
fig. 1 is an overall view of a silver ion dressing of the present invention used after anorectal surgery and gynecological surgery, in which: 1 is a functional layer, and 3 is an adhesive layer;
fig. 2 is a structural view of the silver ion dressing for anorectal surgery and gynecological surgery according to the present invention, wherein: 1 is a functional layer, 2 is a water absorption layer, 3 is an adhesive layer, and 4 is release paper.
Detailed Description
The present invention is further described below by way of specific examples, but the present invention is not limited to only the following examples. Variations, combinations, or substitutions of the invention, which are within the scope of the invention or the spirit, scope of the invention, will be apparent to those of skill in the art and are within the scope of the invention.
Example 1 silver ion dressing for use after anorectal and gynecological operations
The silver ion dressing comprises a functional layer, a water absorption layer, an adhesive layer and release paper:
the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 1mm, and the gram weight of the prepared functional layer is 47.4 g/square meter;
the water absorbing layer comprises the following components in parts by weight:
40 parts of cotton fiber, 65 parts of copolymer of starch and acrylamide/acrylic acid and 15 parts of hydrophobic chitosan fiber, wherein the length of the cotton fiber is 33mm, the linear density is 1.50dtex, the thickness is 2mm, and the gram weight of the prepared water absorption layer is 90.3 g/square meter;
the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness of the adhesive layer is 1mm, and the gram weight of the prepared adhesive layer is 155.1 g/square meter; the pH value of the silver ion dressing is 4.0-7.0.
The preparation method comprises the following steps:
preparing a water absorption layer by a hot melting mode, compounding a functional layer and the water absorption layer together by the hot melting mode, then adhering the functional layer and the water absorption layer to an adhesive layer, covering release paper outside the adhesive layer, and performing irradiation sterilization, wherein the irradiation sterilization conditions are as follows: and (5) carrying out cobalt 60 gamma ray with the dosage of 25-40 kGy to obtain the product.
Example 2 silver ion dressing for use after anorectal and gynecological operations
The silver ion dressing comprises a functional layer, a water absorption layer, an adhesive layer and release paper:
the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 1mm, and the gram weight of the prepared functional layer is 47.4 g/square meter;
the water absorbing layer comprises the following components in parts by weight:
45 parts of cotton fiber, 68 parts of starch grafted acrylate polymer and 20 parts of chitosan fiber, wherein the length of the cotton fiber is 35mm, the linear density is 1.30dtex, the thickness is 2mm, and the gram weight of the prepared water absorption layer is 90.3 g/square meter;
the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness of the adhesive layer is 1mm, and the gram weight of the prepared adhesive layer is 155.1 g/square meter; the pH value of the silver ion dressing is 4.0-7.0.
The preparation method is similar to example 1.
Example 3 silver ion dressing for use after anorectal and gynecological operations
The silver ion dressing comprises a functional layer, a water absorption layer, an adhesive layer and release paper:
the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 1mm, and the gram weight of the prepared functional layer is 47.4 g/square meter;
the water absorbing layer comprises the following components in parts by weight:
50 parts of cotton fiber, 75 parts of copolymer of starch and acrylamide/acrylic acid and 25 parts of hydrophobic chitosan fiber, wherein the length of the cotton fiber is 40mm, the linear density is 1.20dtex, the thickness is 2mm, and the gram weight of the prepared water absorbing layer is 90.3 g/square meter;
the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness of the adhesive layer is 1mm, and the gram weight of the prepared adhesive layer is 155.1 g/square meter; the pH value of the silver ion dressing is 4.0-7.0.
The preparation method is similar to example 1.
Comparative example 1 silver ion dressing for use after anorectal and gynecological operations
The silver ion dressing comprises a functional layer, a water absorption layer, an adhesive layer and release paper:
the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 1mm, and the gram weight of the prepared functional layer is 47.4 g/square meter;
the water absorption layer is made of cotton fibers, the length of the cotton fibers is 35mm, the linear density is 1.30dtex, the thickness of the cotton fibers is 2mm, and the gram weight of the prepared water absorption layer is 90.3 g/square meter;
the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness of the adhesive layer is 1mm, and the gram weight of the prepared adhesive layer is 155.1 g/square meter; the pH value of the silver ion dressing is 4.0-7.0.
The preparation method is similar to example 1.
Comparative example 2 silver ion dressing for use after anorectal and gynecological operations
The silver ion dressing comprises a functional layer, a water absorption layer, an adhesive layer and release paper:
the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 1mm, and the gram weight of the prepared functional layer is 47.4 g/square meter;
the water absorbing layer comprises the following components in parts by weight:
45 parts of cotton fiber, 68 parts of carboxymethyl cellulose fiber and 20 parts of hydrophobic chitosan fiber, wherein the length of the cotton fiber is 35mm, the linear density is 1.30dtex, the thickness is 2mm, and the gram weight of the prepared water absorption layer is 90.3 g/square meter;
the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness of the adhesive layer is 1mm, and the gram weight of the prepared adhesive layer is 155.1 g/square meter; the pH value of the silver ion dressing is 4.0-7.0.
The preparation method is similar to example 1.
Comparative example 3 silver ion dressing for use after anorectal and gynecological operations
The silver ion dressing comprises a functional layer, a water absorption layer, an adhesive layer and release paper:
the functional layer consists of silver ions and medical cotton base cloth, the content of silver in the functional layer is 0.001-1.00% of the mass of the functional layer, the thickness of the functional layer is 1mm, and the gram weight of the prepared functional layer is 47.4 g/square meter;
the water absorbing layer comprises the following components in parts by weight:
45 parts of cotton fiber, 68 parts of starch grafted acrylate polymer and 20 parts of hydrophilic chitosan fiber, wherein the length of the cotton fiber is 35mm, the linear density is 1.30dtex, the thickness is 2mm, and the gram weight of the prepared water absorbing layer is 90.3 g/square meter;
the adhesive layer is a polyethylene pressure-sensitive adhesive layer, the thickness of the adhesive layer is 1mm, and the gram weight of the prepared adhesive layer is 155.1 g/square meter; the pH value of the silver ion dressing is 4.0-7.0.
The preparation method is similar to example 1.
Test example I test for testing the Properties of silver ion dressings
1. Test materials:
the silver ion dressings prepared in example 1, example 2 and example 3.
2. The test method comprises the following steps:
the silver ion dressings prepared in example 1, example 2 and example 3 were tested for product appearance, liquid absorbability, tack, peel strength and bacteriostatic effect (bacteriostatic rate of 24 h). Wherein: the appearance of the product is detected by visual observation; the liquid absorbency was measured with reference to YY/T0471.1-2004, 3.2; the viscosity is detected according to specification B.2 in YY/T0148-2006; the peel strength was determined with reference to the specification B.3 in YY/T0148-2006; the bacteriostasis effect (24h bacteriostasis rate) is detected by referring to a method of 'disinfection technical Specification' 2002 edition.
3. And (3) test results:
the test results are shown in table 1.
Table 1 performance testing of silver ion dressings
As can be seen from Table 1, the silver ion dressing for anorectal surgery and gynecological surgery provided by the invention has the advantages of uniform appearance and color, neat appearance, no foreign matters, and liquid absorbability of more than 22g/100cm2The 24-hour bacteriostasis rate is more than 99.9 percent, and the silver ion dressing is an ideal silver ion dressing.
Test example II Water absorption test of silver ion dressing
1. Test materials:
the silver ion dressings prepared in example 2, comparative example 1, comparative example 2 and comparative example 3.
2. The test method comprises the following steps:
the liquid absorbency of the silver ion dressings prepared in example 2, comparative example 1, comparative example 2 and comparative example 3 was measured with reference to 3.2 in YY/T0471.1-2004.
3. And (3) test results:
the test results are shown in table 2.
Table 2 water absorption test of silver ion dressing
| Liquid absorbency (g/100 cm)2) | |
| Example 2 | 26 |
| Comparative example 1 | 10 |
| Comparative example 2 | 17 |
| Comparative example 3 | 13 |
As can be seen from table 2, the silver ion dressing for use after anorectal surgery and gynecological surgery provided by the present invention has good liquid absorbability, and is suitable for use after anorectal surgery such as: TST postoperative, anal fistula postoperative, perianal abscess postoperative, haemorrhoids postoperative etc. do like after the gynaecology's operation: such as the antibiosis, the impermeability and the nursing of wound surfaces after artificial abortion, drug abortion, cervix uteri, vagina operation, uterus operation and the like, is an ideal moisture absorption and antibiosis dressing.
Claims (9)
1. The utility model provides a silver ion dressing for anorectal postoperative and gynaecology postoperative, includes functional layer, absorbs water layer, adhesive layer and release paper, its characterized in that, the functional layer comprises silver ion and medical cotton base cloth, the layer that absorbs water comprises the following weight of parts's component: 40-50 parts of cotton fiber, 65-75 parts of starch grafted acrylate polymer and 15-25 parts of chitosan fiber; the chitosan fiber is hydrophobic chitosan fiber.
2. The silver ion dressing of claim 1, wherein the functional layer comprises silver in an amount of 0.001 to 1.00% by mass of the functional layer.
3. The silver ion dressing of claim 1, wherein the water-absorbing layer consists of the following components in parts by weight:
45 parts of cotton fiber, 68 parts of starch grafted acrylate polymer and 20 parts of chitosan fiber.
4. The silver ion dressing of claim 1, wherein said cotton fibers have a length of 33 to 40mm and a linear density of 1.50 to 1.20 dtex.
5. The silver ion dressing of claim 1, wherein said starch grafted acrylate based polymer is a copolymer of starch and acrylamide/acrylic acid.
6. The silver ion dressing of claim 1, wherein said adhesive layer is a polyethylene pressure sensitive adhesive layer.
7. The silver ion dressing of claim 1, wherein the silver ion dressing has a pH of 4.0 to 7.0.
8. The silver ion dressing of claim 1, wherein said silver ion dressing is attached by means of being attached to the inside of the underpants of the patient.
9. The method for preparing the silver ion dressing according to any one of claims 1 to 8, comprising the steps of:
preparing a water absorption layer by a hot melting mode, compounding a functional layer and the water absorption layer together by the hot melting mode, adhering the functional layer and the water absorption layer to an adhesive layer, covering release paper outside the adhesive layer, and performing irradiation sterilization, wherein the irradiation sterilization conditions are as follows: and (5) carrying out cobalt 60 gamma ray with the dosage of 25-40 kGy to obtain the product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910335565.8A CN110025815B (en) | 2019-04-24 | 2019-04-24 | Silver ion dressing used after anorectal operation and gynecological operation and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910335565.8A CN110025815B (en) | 2019-04-24 | 2019-04-24 | Silver ion dressing used after anorectal operation and gynecological operation and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
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| CN110025815A CN110025815A (en) | 2019-07-19 |
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| CN110522719A (en) * | 2019-09-16 | 2019-12-03 | 江苏美生元生物科技有限公司 | A kind of preparation method of vagina externally used antimicrobial gel |
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| US7462753B2 (en) * | 2006-06-19 | 2008-12-09 | Chung Shan Institute Of Science And Technology, Armaments Bureau, M.N.D. | Nano-silver wound dressing |
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| CN202458927U (en) * | 2012-03-30 | 2012-10-03 | 深圳市源兴纳米医药科技有限公司 | Nano-silver antimicrobial self-adhesive tape capable of powerfully sucking pus |
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| CN206508116U (en) * | 2016-08-16 | 2017-09-22 | 广东泰宝医疗科技股份有限公司 | A kind of dressing of hemorrhoid Postoperative Dressing |
| CN108066065A (en) * | 2018-01-02 | 2018-05-25 | 成都美益达医疗科技有限公司 | The new Wound dressing that a kind of patient in hospital uses |
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