CN117471082A - Reaction cup detection method and sample analyzer - Google Patents
Reaction cup detection method and sample analyzer Download PDFInfo
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- CN117471082A CN117471082A CN202210869214.7A CN202210869214A CN117471082A CN 117471082 A CN117471082 A CN 117471082A CN 202210869214 A CN202210869214 A CN 202210869214A CN 117471082 A CN117471082 A CN 117471082A
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 237
- 238000001514 detection method Methods 0.000 title claims abstract description 35
- 238000000034 method Methods 0.000 claims description 35
- 230000001960 triggered effect Effects 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 3
- 238000012360 testing method Methods 0.000 abstract description 12
- 239000003153 chemical reaction reagent Substances 0.000 description 23
- 239000011324 bead Substances 0.000 description 7
- 238000007885 magnetic separation Methods 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 238000003018 immunoassay Methods 0.000 description 4
- 230000002159 abnormal effect Effects 0.000 description 3
- 238000001917 fluorescence detection Methods 0.000 description 3
- 239000000872 buffer Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
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- 230000008588 hemolysis Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
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- 239000013307 optical fiber Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
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- G01V—GEOPHYSICS; GRAVITATIONAL MEASUREMENTS; DETECTING MASSES OR OBJECTS; TAGS
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Abstract
The application discloses a reaction cup detection method and a sample analyzer. The reaction cup detection method is applied to a sample analyzer, the sample analyzer comprises a placing tray for placing reaction cups, the placing tray comprises a plurality of cup positions, the plurality of cup positions are divided into N rows of cup positions, each row of cup positions comprises M cup positions, and the detection method comprises the following steps: sequentially detecting whether the reaction cups are placed at the first row of cup positions; if the fact that the reaction cup is placed in the mth cup position of the first row of cup positions is detected, sequentially detecting whether the reaction cup is placed in the mth-1 cup positions in other rows of cup positions; if the m-1 th cup position in the other row of cup positions is detected to be provided with the reaction cups, determining the number of the reaction cups in the placing tray according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions. Through the embodiment, the detection time for detecting the reaction cup in the placing plate can be greatly shortened, and the test efficiency of the sample analyzer is improved.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to a reaction cup detection method and a sample analyzer.
Background
Sample analyzers have undergone several different development phases, such as radioimmunoassay, fluorescent immunoassay, enzyme-labeled immunoassay, chemiluminescent immunoassay, and the like.
Sample analyzers have trays for placing reaction cups, such as trays including reaction trays and the like, which typically have more cup locations for placing reaction cups, one reaction cup per cup location.
Before the sample analyzer tests, the placing condition of the reaction cups in the placing tray is detected, however, if the traditional mode is adopted, each cup position in the placing tray is detected one by one, a long time is needed, the testing time of the sample analyzer can be prolonged, and the efficient testing effect of the sample analyzer is difficult to realize.
Disclosure of Invention
In order to solve the above problems in the prior art, the present application provides a reaction cup detection method and a sample analyzer.
In order to solve the above problems, the present application provides a reaction cup detection method, which is applied to a sample analyzer, the sample analyzer includes a placement tray for placing reaction cups, the placement tray includes a plurality of cup positions, the plurality of cup positions are divided into N rows of cup positions, each row of cup positions includes M cup positions, and M and N are natural numbers greater than or equal to 2, the detection method includes: sequentially detecting whether the reaction cups are placed at the first row of cup positions; if the fact that the reaction cup is placed at the mth cup position of the first row of cup positions is detected, sequentially detecting whether the reaction cup is placed at the mth-1 cup position in other rows of cup positions, wherein M is a natural number which is more than 1 and less than or equal to M; if the m-1 th cup position in the other row of cup positions is detected to be provided with the reaction cups, determining the number of the reaction cups in the placing tray according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions.
To solve the above-described problems, embodiments of the present application provide a sample analyzer including a placement tray for placing a cuvette, the sample analyzer being configured to perform the above-described detection method.
Compared with the prior art, the reaction cup detection method is applied to a sample analyzer, the sample analyzer comprises a placing disc for placing reaction cups, the placing disc comprises a plurality of cup positions, the plurality of cup positions are divided into N rows of cup positions, each row of cup positions comprises M cup positions, M and N are natural numbers which are more than or equal to 2, and the detection method comprises the following steps: sequentially detecting whether the reaction cups are placed at the first row of cup positions; if the fact that the reaction cup is placed in the mth cup position of the first row of cup positions is detected, sequentially detecting whether the reaction cup is placed in the mth-1 cup positions in other rows of cup positions, wherein M is a natural number which is more than 1 and less than or equal to M; if the m-1 th cup position in the other row of cup positions is detected to be provided with the reaction cups, determining the number of the reaction cups in the placing tray according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions. Through the embodiment, whether the reaction cups are placed in the first row of cup positions or not is sequentially detected, when the reaction cups are placed in the mth cup position of the first row of cup positions, whether the reaction cups are placed in the mth-1 th cup positions of other row of cup positions or not is sequentially detected, so that the quantity of the reaction cups in the placing tray is determined according to the detection result, the cup holes in each placing tray are not required to be detected, the detection time for detecting the reaction cups in the placing tray can be greatly shortened, and the test efficiency of the sample analyzer is improved.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic flow chart of a first embodiment of a method for detecting a reaction cup provided in the present application;
FIG. 2 is a schematic structural view of an embodiment of a placement tray provided herein;
FIG. 3 is a schematic structural view of another embodiment of a placing tray provided in the present application;
fig. 4 is a flow chart of a second embodiment of the method for detecting a reaction cup provided in the present application.
Detailed Description
The present application is described in further detail below with reference to the drawings and examples. It is specifically noted that the following examples are only for illustration of the present application, but do not limit the scope of the present application. Likewise, the following embodiments are only some, but not all, of the embodiments of the present application, and all other embodiments obtained by one of ordinary skill in the art without inventive effort are within the scope of the present application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
In the description of the present application, it is to be understood that the terms "mounted," "configured," "connected," and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected, unless explicitly stated and defined otherwise; the connection can be mechanical connection or electric connection; may be directly connected or may be connected via an intermediate medium. It will be apparent to those skilled in the art that the foregoing is in the specific sense of this application.
The application provides a sample analyzer, which comprises a placing tray for placing a reaction cup. Among them, the sample analyzer is applied to the field of medical or biochemical analysis. A more common sample analyzer may be an immunoassay analyzer; the sample analyzer may also be other clinical laboratory equipment. The placement tray may include a reaction tray, and in other embodiments, any configuration having a cup location for placement of a reaction cup may be used herein.
The sample analyzer of the present application can be used for fluorescence detection of a sample. The immunity analyzer comprises a transportation module, a sampling module, a reagent module, a reaction module, a magnetic separation module and a fluorescence detection module. When the device is used, an original sample is transferred to the sampling module through the transportation module, the original sample is quantitatively sampled by utilizing the sampling of the sampling module, and the original sample is transferred to the reaction module to wait for reaction. The reagent module is used for containing and preparing a reagent required by sample detection, the transportation module transports the reagent which is required to be added into the sample to the reagent station, and a reagent needle of the reagent module absorbs the corresponding reagent and accurately and quantitatively adds the corresponding reagent into a reaction cup of a reaction disc of the reaction module, wherein the reagent comprises magnetic beads with specific antibodies.
The sampling needle adds the original sample to the reaction cup of the reaction plate, and the original sample needs to be incubated on the reaction plate for a period of time in order to combine the antigen in the original sample with the specific antibody in the reagent. After incubation, the magnetic separation module carries out magnetic separation on the incubated sample mixture, in the magnetic separation module, cells which do not react with the specific antibodies are separated through an immunomagnetic bead separation technology, and a magnetic bead composition obtained through magnetic separation is cleaned, so that reagents and other wastes which are not combined with the magnetic beads in a reaction disk are cleaned, and a sample to be detected is obtained. The fluorescence detection module detects a sample to be detected and converts photoelectric data to obtain detection data.
Throughout the workflow of a sample analyzer, there are numerous links to the use of solutions for the corresponding work processes, which may include buffers, hemolysis agents, reagents, etc., for example.
Taking a solution as an example, the buffer may be used for washing in a sample analyzer, specifically, washing includes but is not limited to reagent needle washing, cuvette washing, magnetic bead washing, and the like. The reagent module of the sample analyzer is provided with a cleaning position when various reagents are filled in the reaction disk, and after one reagent is filled in each reagent needle, the reagent needle needs to be cleaned at the cleaning position, so that the pollution of other reagents in the process of reusing the reagent needle is avoided; a plurality of reaction cup positions are arranged on a reaction disk of the sample analyzer, reagents, magnetic beads, original samples and the like are filled in the reaction cups, and after detection is completed, the reaction cups are required to be sucked and cleaned, so that the accuracy of subsequent detection results is prevented from being influenced; in the magnetic separation module, the reagent and other wastes which are not combined with the magnetic beads in the reaction disk are required to be cleaned, so that substances which are not combined with the reaction liquid and interfering substances in the reaction process are removed.
Referring to fig. 1, fig. 1 is a schematic flow chart of a first embodiment of a method for detecting a reaction cup provided in the present application. The cuvette detection method can be applied to the sample analyzer, and specifically, the method can comprise the following steps S101 to S103.
Step S101: and sequentially detecting whether the reaction cups are placed at the first row of cup positions.
The placing tray comprises a plurality of cup positions, the plurality of cup positions are divided into N rows of cup positions, each row of cup positions comprises M cup positions, M and N are natural numbers which are more than or equal to 2, namely, the cup positions of the placing tray can be divided into N rows and M columns and are distributed in an array. Referring to fig. 2 and 3, fig. 2 is a schematic structural view of an embodiment of a placing tray provided in the present application. Fig. 3 is a schematic structural view of another embodiment of a placing tray provided in the present application. In the placement tray shown in fig. 2 and 3, the placement tray has 36 cup positions in total, and is divided into 6 rows of cup positions, each row having 6 cup positions. Wherein the cup positions can be divided in a way that the cup positions with the serial numbers of 1-6 are in one row and the cup positions with the serial numbers of 7-12 are in one row. It is also possible to divide the numbers 1, 7, 13, 19, 25, 31 into a row, i.e. corresponding to the way of placing the discs shown in fig. 3. That is, in the embodiment of the present application, the cup positions in the tray may be placed in a row, or the cup positions in the tray may be placed in a column. In the following embodiments, the description will be made mainly in terms of a row of cup positions in a tray.
When a row of cup positions in the placing tray is used, whether the reaction cups are placed in the first row of cup positions is sequentially detected, namely, the detection is started from the first row of 1 positions in the placing tray, and then the 2 positions and the 3 positions are sequentially detected from left to right until the 6 positions are sequentially detected. Of course, in the placement tray shown in fig. 3, if a row of cup positions in the placement tray is used, it is sequentially detected whether the reaction cup is placed in the first row of cup positions, that is, from the first row of position 1 in the placement tray, then sequentially detecting the position 2, the position 3 and the position 6 from top to bottom.
Step S102: if the reaction cup is placed at the m-th cup position of the first row of cup positions, sequentially detecting whether the reaction cup is placed at the m-1 th cup position in the other row of cup positions.
Wherein M is a natural number greater than 1 and less than or equal to M. When the reaction cup is placed at the m-th cup position of the first row of cup positions, the subsequent cup positions of the m-th cup positions of the first row of cup positions and the cup positions behind the m-th cup positions in other rows of cup positions can be considered to have the reaction cup, at the moment, the step of sequentially detecting whether the reaction cup is placed at the first row of cup positions can be stopped, and the step of sequentially detecting whether the reaction cup is placed at the m-1 th cup positions in the other rows of cup positions can be started. Taking the placing tray shown in fig. 2 and 3 as an example, when detecting the cup positions 1 to 6 in the first row in sequence, if detecting the presence of a reaction cup in the cup position 3, it is not necessary to detect whether the reaction cup is in the cup position 4, but the detection in the cup position sequence can be stopped when detecting the presence of a reaction cup in any one of the cup positions, starting from the cup position 8, according to the sequence from the cup position 8 to the cup position 14 to the cup position 32, the cup position 14, the cup position 20, the cup position 26 and the cup position 32.
Step S103: if the m-1 th cup position in the other row of cup positions is detected to be provided with the reaction cups, determining the number of the reaction cups in the placing tray according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions.
If the m-1 th cup position in the other row of cup positions is detected to be placed with the reaction cup, the m-1 th cup position in the rest other row of cup positions can be considered to be the reaction cup, and the step of continuously detecting the m-1 th cup position in the other row of cup positions to be placed with the reaction cup can be stopped, and the number of the reaction cups in the placing tray is calculated according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions. Taking the placing tray shown in fig. 2 and 3 as an example, when the number 14 cup position, the number 20 cup position, the number 26 cup position and the number 32 cup position are sequentially detected in the sequence from the number 8 cup position to the number 14 cup position and from the number 14 cup position to the number 32 cup position by taking the number 8 as a starting point, and the number 14 cup position is detected to have the reaction cups, the number 20 cup position, the number 26 cup position and the number 32 cup position are determined to have the reaction cups, and the number of the reaction cups in the placing tray can be determined to be 28 reaction cups at the moment.
In one embodiment, the step of determining the number of reaction cups in the placement tray according to the position of the m-th cup position of the first row of cup positions and the positions of the m-1 th cup positions in the other rows of cup positions (step S103) includes: if the reaction cups are detected to be placed at the (m-1) th cup position in the nth row of the cup positions of the other rows, the number of the reaction cups in the placement tray is calculated according to the following mode: the number of reaction cups in the placement tray = (M-m+1) ×n+ (N-N), where N is a natural number greater than 1 and less than N.
When detecting that the reaction cup is placed at the m-th cup position of the first row of cup positions, the following cup positions of the m-th cup position of the first row can be identified, and the reaction cups exist at the cup positions after the m-th cup position of the other rows; when detecting that the reaction cup is placed at the m-1 th cup position in the nth row of cup positions, the residual cup positions in other rows can be identified to exist in the reaction cups. The formula can be used at this time: the number of reaction cups in the placing tray= (M-m+1) ×n+ (N-n+1), and the number of reaction cups in the placing tray is calculated. Taking the placing tray shown in fig. 2 and 3 as an example, if the reaction cup exists at the cup position No. 3, when the reaction cup exists at the cup position No. 14 in the third row, the number of the reaction cups in the placing tray= (6-3+1) ×6+6-3+1=28.
In one embodiment, determining the number of reaction cups in the placement tray according to the position of the m-th cup position of the first row of cup positions and the positions of the m-1 th cup positions in the other rows of cup positions comprises: if the m-1 th cup position in the other row of cup positions is detected to be not provided with the reaction cups, the number of the reaction cups in the placing tray is calculated according to the following mode: the number of reaction cups in the placement tray= (M-m+1) ×n.
When detecting that the reaction cup is placed at the m-th cup position of the first row of cup positions, the following cup positions of the m-th cup position of the first row can be identified, and the reaction cups exist at the cup positions after the m-th cup position of the other rows; when the m-1 th cup position in the other rows of cup positions is detected to be not provided with a reaction cup. The formula can be used at this time: the number of reaction cups in the placing tray= (M-m+1) ×n is calculated to obtain the number of reaction cups in the placing tray. Taking the placing tray shown in fig. 2 and fig. 3 as an example, if it is detected that the reaction cup exists at the cup position No. 3, and none of the cup positions listed in the row No. 2, the number of the reaction cups in the placing tray= (6-3+1) ×6=24 with the position No. 3 as the starting position.
In one embodiment, after the step of sequentially detecting whether the reaction cups are placed in the first row of cup positions (step S101), the method includes: if the fact that the reaction cup is not placed in the first row of cup positions is detected, sequentially detecting whether the reaction cup is placed in the last cup position in other row of cup positions or not; if the last cup position in the nth row of the cup positions of the other rows is detected to be provided with the reaction cups, the number of the reaction cups in the placing tray is calculated according to the following mode: the number of reaction cups in the holding tray = N-N +1, where N is a natural number greater than 1 and less than N.
When the reaction cups are detected to be not placed in the first row of cup positions, no reaction cups are detected in the cup positions except the last row, at the moment, whether the reaction cups exist in the other cup positions in the last row or not is only detected, and when the reaction cups are detected to be placed in the last cup position in the nth row, the reaction cups can be detected to exist in the last cup positions in the other rows after the nth row. The formula can be used at this time: the number of reaction cups in the placing tray = N-N +1 is calculated as the number of reaction cups in the placing tray. Taking the placing tray shown in fig. 2 and 3 as an example, if no reaction cup exists in the cup positions 1-6, at this time, whether a reaction cup exists in a row of cup positions including the 6 th position can be sequentially detected, and when the reaction cup exists in the 18 th position, the number of the reaction cups in the placing tray=n-n+1=6-3+1=4.
In one embodiment, after sequentially detecting whether the last cup position in the other rows of cup positions is provided with a reaction cup, the method comprises the following steps: and if the last cup position in the other cup rows is detected to be not provided with the reaction cup, determining that the reaction cup is not arranged in the arranging disc. At this time, the fact that the reaction cups are not stored in the reaction tray can be realized only through M+N-1 times of detection, and compared with the fact that each detection device detects each detection device, the detection time for detecting the reaction cups in the detection placement tray can be greatly shortened, and the test efficiency of the sample analyzer is improved.
In one embodiment, after sequentially detecting whether the reaction cups are placed in the first row of cup positions, the method comprises the following steps: if the 1 st cup position of the first row of cup positions is detected to be provided with the reaction cup, determining that all cup positions in the placing tray are provided with the reaction cup.
In order to realize the accuracy of the reaction cup detection, the reaction cup can be rechecked in the placing tray during the test by using the sample analyzer, and referring to fig. 4, fig. 4 is a flow diagram of a second embodiment of the reaction cup detection method provided in the application. Specifically, the method may include the following steps S201 to S207.
Step S201: and sequentially detecting whether the reaction cups are placed at the first row of cup positions.
Step S202: if the reaction cup is placed at the m-th cup position of the first row of cup positions, sequentially detecting whether the reaction cup is placed at the m-1 th cup position in the other row of cup positions.
Step S203: if the m-1 th cup position in the other row of cup positions is detected to be provided with the reaction cups, determining the number of the reaction cups in the placing tray according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions.
The steps S201 to S203 are the same as the steps S101 to S103, and are not described herein.
Step S204: the m-1 cup position in other rows of cup positions is used as the initial position for placing the disc.
When detecting that the reaction cup is placed at the m-th cup position of the first row of cup positions, the following cup positions of the m-th cup position of the first row can be identified, and the reaction cups exist at the cup positions after the m-th cup position of the other rows; when the reaction cup is detected to be placed at the m-1 th cup position in the other rows of cup positions, the reaction cup can be identified to exist at the m-1 th cup position in the rest other rows. At this time, the m-1 th cup position in the other rows of cup positions can be used as the initial position for placing the tray, so that the sample analyzer can test from the m-1 th cup position. Taking the placing tray shown in fig. 2 as an example, when detecting the cup position No. 3 and detecting the cup position No. 14, the cup position No. 14 is taken as the initial position of the placing tray.
Step S205: and after a row from the initial position to the last cup position of the m-1 cup positions in other rows, sequentially performing the operation of grabbing the reaction cups one by one according to the cup position of the row in which the sequence gradually increases with the m-1 cup positions.
The sample analyzer can execute grabbing operation on the reaction cup when testing, and if the grabbing operation fails, the reaction cup is determined to be abnormal at the cup position. Taking the placing tray shown in fig. 2 as an example, when detecting that the reaction cup exists in the cup position 3 and the cup position 14, the placing tray can first grasp one row with the cup position 14, grasp one row with the cup position 3, grasp one row with the cup position 4, grasp one row with the cup position 5 and grasp one row with the cup position 6 one by one.
Step S206: if an operation result that the reaction cup is failed to be grabbed at the xth cup position is detected, whether an operation instruction for replacing the placing disc is triggered or not is monitored in real time.
If the operation result of failure in grabbing the reaction cup at the x-th cup position is detected in the process of testing the sample analyzer, the reaction cup may not exist at the x-th cup position in the reaction disc, and the sample analyzer can conduct fault reminding at the moment, and can monitor whether the operation that a user opens the light shield, the instrument door part, the drawing placing disc and the like possibly replaces the placing disc in real time in the process. Wherein the xth cup position comprises any cup position which is determined to exist in the process of detecting the reaction cup before executing.
Step S207: if yes, returning to the step to sequentially detect whether the reaction cups are placed in the first row of cup positions.
When detecting that there may be an operation instruction triggering replacement of the placing tray, it may be determined that the placing tray has been replaced, and step S101 is required to sequentially detect whether the reaction cups are placed in the first row of cup positions.
In one embodiment, after the step of monitoring in real time whether the operation instruction for replacing the placing tray is triggered, the method includes: if not, detecting whether a reaction cup exists at the x-th cup position; if the reaction cup exists at the x-th cup position, the reaction cups are obtained according to the operation sequence of grabbing the reaction cups and at the cup positions after the x-th cup position.
When detecting that the operation command for replacing the placing disc is not triggered within a period of time, the x-th cup position can be detected again, so that the possibility of incorrect conclusion caused by grabbing operation errors is avoided. When the reaction cup exists in the x-th cup position, the fact that the reaction cup does not exist in the x-th cup position is determined to be a grabbing operation error, and at the moment, the fact that the reaction cups exist in the cup positions after the x-th cup position according to the operation sequence of grabbing the reaction cups can be determined.
In one embodiment, after detecting the presence of a reaction cup at the xth cup position, the method comprises: if the fact that the reaction cup does not exist in the x-th cup position is detected, detecting whether a reaction cup exists in the next cup position of the x-th cup position according to the operation sequence of grabbing the reaction cup; if the next cup position is detected to have the reaction cup, obtaining the reaction cup which is arranged at the cup position after the next cup position according to the operation sequence of grabbing the reaction cup; if the next cup position is detected to be free of the reaction cup, the reaction cup is not arranged at the cup position after the next cup position according to the operation sequence of grabbing the reaction cup.
The sample analyzer can execute grabbing operation on the reaction cup when testing, and if the grabbing operation fails, the reaction cup is determined to be abnormal at the cup position. Taking the placing tray shown in fig. 2 as an example, when detecting that the reaction cup exists in the cup position 3 and the cup position 14, the placing tray can first grasp one row with the cup position 14, grasp one row with the cup position 3, grasp one row with the cup position 4, grasp one row with the cup position 5 and grasp one row with the cup position 6 one by one. When detecting that the No. 18 cup position (x cup position) does not have a reaction cup, continuously detecting whether the No. 24 cup position (next cup position) has the reaction cup, and if detecting that the No. 24 cup position has the reaction cup, obtaining that the cup positions behind the next cup position have the reaction cup according to the operation sequence of grabbing the reaction cup, namely, the No. 30 cup position and the No. 36 cup position have the reaction cup. If no reaction cup exists in the 24 # cup positions, the reaction cup is not available in the cup positions after the next cup position (the 24 # cup position) according to the operation sequence of grabbing the reaction cup, namely, the reaction cup is not available in the 30 # cup position and the 36 # cup position, at the moment, the detection flow can be ended, and the abnormal condition of the reaction cup in the placing tray is reported.
Through the embodiment, whether the reaction cups are placed in the first row of cup positions or not is sequentially detected, when the reaction cups are placed in the mth cup position of the first row of cup positions, whether the reaction cups are placed in the mth-1 th cup positions of other row of cup positions or not is sequentially detected, so that the quantity of the reaction cups in the placing tray is determined according to the detection result, the cup holes in each placing tray are not required to be detected, the detection time for detecting the reaction cups in the placing tray can be greatly shortened, and the test efficiency of the sample analyzer is improved.
In addition, the above-described functions, if implemented in the form of software functions and sold or used as a separate product, may be stored in a mobile terminal-readable storage medium, that is, the present application also provides a storage device storing program data that can be executed to implement the method of the above-described embodiment, the storage device may be, for example, a U-disk, an optical disk, a server, or the like. That is, the present application may be embodied in a software product that includes instructions for causing a smart terminal to perform all or part of the steps of the methods described in the various embodiments.
In the description of the present application, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" is at least two, such as two, three, etc., unless explicitly defined otherwise.
Any process or method descriptions in flow charts or otherwise described herein may be understood as representing modules, segments, or portions of code which include one or more executable instructions for implementing specific logical functions or steps of the process, and further implementations are included within the scope of the preferred embodiment of the present application in which functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art of the embodiments of the present application.
Logic and/or steps represented in the flowcharts or otherwise described herein, e.g., may be considered as a ordered listing of executable instructions for implementing logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device (which can be a personal computer, server, network device, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions). For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). In addition, the computer readable medium may even be paper or other suitable medium on which the program is printed, as the program may be electronically captured, via, for instance, optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner, if necessary, and then stored in a computer memory.
The foregoing description is only of embodiments of the present application, and is not intended to limit the scope of the patent application, and all equivalent structures or equivalent processes using the descriptions and the contents of the present application or other related technical fields are included in the scope of the patent application.
Claims (10)
1. A reaction cup detection method, characterized in that it is applied to a sample analyzer, the sample analyzer includes a placement tray for placing reaction cups, the placement tray includes a plurality of cup positions, the plurality of cup positions are divided into N rows of cup positions, each row of cup positions includes M cup positions, M and N are natural numbers greater than or equal to 2, the detection method includes:
sequentially detecting whether the reaction cups are placed at the first row of cup positions;
if the fact that the reaction cup is placed at the mth cup position of the first row of cup positions is detected, sequentially detecting whether the reaction cup is placed at the mth-1 cup position in other rows of cup positions, wherein M is a natural number which is more than 1 and less than or equal to M;
if the m-1 th cup position in the other row of cup positions is detected to be provided with the reaction cups, determining the number of the reaction cups in the placing tray according to the m-1 th cup position in the first row of cup positions and the m-1 th cup position in the other row of cup positions.
2. The method of claim 1, wherein determining the number of reaction cups in the placement tray according to the position of the mth cup of the first row of cup positions and the positions of the m-1 th cup positions in the other rows of cup positions, comprises:
if the reaction cups are detected to be placed at the m-1 th cup position in the nth row of the cup positions of the other rows, the number of the reaction cups in the placement tray is calculated according to the following mode:
the number of reaction cups in the placing tray= (M-m+1) ×n+ (N-n+1), wherein N is a natural number greater than 1 and less than N.
3. The method of claim 1, wherein determining the number of reaction cups in the placement tray according to the position of the mth cup of the first row of cup positions and the positions of the m-1 th cup positions in the other rows of cup positions, comprises:
if the m-1 th cup position in the other row of cup positions is detected to be not provided with the reaction cups, the number of the reaction cups in the placing tray is calculated according to the following mode:
the number of reaction cups in the placement tray= (M-m+1) ×n.
4. The method according to claim 1, wherein after sequentially detecting whether the reaction cups are placed in the first row of cups, the method comprises:
if the fact that the reaction cup is not placed in the first row of cup positions is detected, sequentially detecting whether the reaction cup is placed in the last cup position in other row of cup positions or not;
if the last cup position in the nth row of the cup positions of the other rows is detected to be provided with the reaction cups, the number of the reaction cups in the placing tray is calculated according to the following mode:
the number of reaction cups in the placing tray=n-n+1, wherein N is a natural number greater than 1 and less than N.
5. The method according to claim 4, wherein after sequentially detecting whether the reaction cup is placed in the last cup position in the other rows of cup positions, the method comprises:
and if the last cup position in the other rows of cup positions is detected to be not provided with the reaction cup, determining that the reaction cup is not arranged in the arranging disc.
6. The method according to claim 1, wherein after sequentially detecting whether the reaction cups are placed in the first row of cups, the method comprises:
if the 1 st cup position of the first row of cup positions is detected to be provided with the reaction cup, determining that all cup positions in the placing tray are provided with the reaction cup.
7. The method according to claim 1, wherein after determining the number of reaction cups in the placement tray according to the position of the mth cup position of the first row of cup positions and the position of the m-1 th cup position in the other row of cup positions, the method comprises:
taking the (m-1) th cup position in the other rows of cup positions as the initial position of the placing tray;
sequentially performing the operation of grabbing the reaction cups one by one according to a row from the start position to the last cup position of the m-1 th cup positions in the other rows and then according to a row of cup positions in the order of gradually increasing with the m-1 th cup positions;
if an operation result that the reaction cup is failed to be grabbed at the xth cup position is detected, monitoring whether an operation instruction for replacing the placing disc is triggered or not in real time;
if yes, returning to the step to sequentially detect whether the reaction cups are placed in the first row of cup positions.
8. The method according to claim 7, wherein after monitoring in real time whether the operation instruction for replacing the placing tray is triggered, the method comprises:
if not, detecting whether a reaction cup exists in the xth cup position;
and if the reaction cup exists in the x-th cup position, obtaining the reaction cup in the cup positions after the x-th cup position according to the operation sequence of grabbing the reaction cup.
9. The method of claim 8, wherein after said detecting whether a reaction cup is present at said x-th cup position, said method comprises:
if the fact that the reaction cup does not exist in the x-th cup position is detected, detecting whether a reaction cup exists in the next cup position of the x-th cup position according to the operation sequence of grabbing the reaction cup;
if the reaction cup exists in the next cup position, obtaining the reaction cups in the cup positions after the next cup position according to the operation sequence of grabbing the reaction cups;
and if the fact that the reaction cup does not exist in the next cup position is detected, obtaining that no reaction cup exists in the cup positions after the next cup position according to the operation sequence of grabbing the reaction cup.
10. A sample analyzer comprising a placement tray for placing a cuvette, the sample analyzer being adapted to perform the detection method according to any of claims 1-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210869214.7A CN117471082A (en) | 2022-07-21 | 2022-07-21 | Reaction cup detection method and sample analyzer |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210869214.7A CN117471082A (en) | 2022-07-21 | 2022-07-21 | Reaction cup detection method and sample analyzer |
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| Publication Number | Publication Date |
|---|---|
| CN117471082A true CN117471082A (en) | 2024-01-30 |
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|---|---|---|---|
| CN202210869214.7A Pending CN117471082A (en) | 2022-07-21 | 2022-07-21 | Reaction cup detection method and sample analyzer |
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| Country | Link |
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| CN (1) | CN117471082A (en) |
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2022
- 2022-07-21 CN CN202210869214.7A patent/CN117471082A/en active Pending
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