CN117462854A - Photodynamic therapy system and method for tumor - Google Patents
Photodynamic therapy system and method for tumor Download PDFInfo
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- CN117462854A CN117462854A CN202311608614.3A CN202311608614A CN117462854A CN 117462854 A CN117462854 A CN 117462854A CN 202311608614 A CN202311608614 A CN 202311608614A CN 117462854 A CN117462854 A CN 117462854A
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- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 55
- 238000002428 photodynamic therapy Methods 0.000 title claims abstract description 39
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000011282 treatment Methods 0.000 claims abstract description 51
- 239000013307 optical fiber Substances 0.000 claims abstract description 40
- 239000003504 photosensitizing agent Substances 0.000 claims abstract description 28
- 238000012544 monitoring process Methods 0.000 claims abstract description 25
- 230000003287 optical effect Effects 0.000 claims abstract description 21
- 230000005540 biological transmission Effects 0.000 claims abstract description 14
- 230000008569 process Effects 0.000 claims description 12
- 230000000694 effects Effects 0.000 claims description 9
- 238000012545 processing Methods 0.000 claims description 6
- 238000013523 data management Methods 0.000 claims description 5
- 238000013500 data storage Methods 0.000 claims description 5
- 238000007405 data analysis Methods 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 206010052428 Wound Diseases 0.000 claims description 3
- 208000027418 Wounds and injury Diseases 0.000 claims description 3
- DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 claims description 3
- 230000002924 anti-infective effect Effects 0.000 claims description 3
- 238000001574 biopsy Methods 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 3
- 230000001427 coherent effect Effects 0.000 claims description 3
- 239000004020 conductor Substances 0.000 claims description 3
- 238000011156 evaluation Methods 0.000 claims description 3
- 238000003384 imaging method Methods 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000007726 management method Methods 0.000 claims description 3
- 230000000737 periodic effect Effects 0.000 claims description 3
- 238000005086 pumping Methods 0.000 claims description 3
- 238000002310 reflectometry Methods 0.000 claims description 3
- 238000007619 statistical method Methods 0.000 claims description 3
- 239000012780 transparent material Substances 0.000 claims description 3
- DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 claims description 2
- 229960002105 amrinone Drugs 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- WREDNSAXDZCLCP-UHFFFAOYSA-N methanedithioic acid Chemical compound SC=S WREDNSAXDZCLCP-UHFFFAOYSA-N 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 abstract description 2
- 238000013461 design Methods 0.000 abstract description 2
- 230000006378 damage Effects 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010034972 Photosensitivity reaction Diseases 0.000 description 1
- 208000000453 Skin Neoplasms Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 150000002023 dithiocarboxylic acids Chemical class 0.000 description 1
- 230000005281 excited state Effects 0.000 description 1
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- 208000014829 head and neck neoplasm Diseases 0.000 description 1
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- 230000001105 regulatory effect Effects 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0642—Irradiating part of the body at a certain distance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
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- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
The invention provides a photodynamic therapy system and a photodynamic therapy method for tumors, and relates to the field of photodynamic therapy. The photodynamic therapy system for the tumor comprises a photosensitizer, a laser light source, a light transmission system, a monitoring and control system and a data recording and analyzing system, wherein the laser light source comprises a laser, a light emitting diode and an optical fiber light source, the light transmission system comprises a light guide, an optical fiber and a light guide pipe, and the monitoring and control system comprises an optical power meter, a photosensitizer concentration monitoring system, a temperature monitoring system and a control unit. The depth and the range of light transmission are increased by using the light guide capable of carrying a plurality of optical fibers, the optical fibers are inserted into a treatment area through the surface of the skin, the tail ends of the optical fibers can be placed near tumor tissues, so that the light of a light source can be transmitted to the tumor area, the irradiation of tumors is realized, reasonable light irradiation design is carried out according to the positions and the shapes of the tumors, and the problem of insufficient irradiation quantity of dead cancer cells of normal cells is avoided.
Description
Technical Field
The invention relates to the technical field of photodynamic therapy, in particular to a photodynamic therapy system and a photodynamic therapy method for tumors.
Background
Photodynamic therapy of tumors is a method of treating tumors using photosensitizers and laser light sources of specific wavelengths. It combines photochemical and photothermal effects, and activates photosensitizers to induce cell injury and death, thereby achieving the purpose of treating tumor. The basic principle of photodynamic therapy is as follows: the patient first receives an injection of a particular photosensitizer. A photosensitizer is a specific drug or compound that has photosensitivity to a specific wavelength. Photosensitizers accumulate in tumor tissue or target tumor cells in vivo. A laser light source of a specific wavelength is irradiated to the tumor region at a certain time after the photosensitizer is injected. The laser light source activates the photosensitizer to bring it into an excited state, producing an active substance. The activated photosensitizer will interact with oxygen molecules to produce reactive oxygen molecules, such as singlet oxygen. Active oxygen molecules have strong oxidizing property, can damage cell membranes and damage internal structures of cells, and cause damage and death of tumor cells. In addition to photochemical effects, photodynamic therapy can also destroy tumor cells by photothermal effects. After activation, the photosensitizer may generate localized heat, raising the temperature of the tumor tissue, which in turn leads to apoptosis or necrosis. Photodynamic therapy has certain advantages such as topical treatment, selective action, non-invasive and fewer side effects. It can be used for treating various tumor types including superficial skin cancer, early lung cancer, head and neck tumor, etc.
In deep tumor treatment, the penetration depth of laser beams may be limited, so that the full irradiation of tumors is difficult to achieve, and therefore, according to the invention of the applicant, a photodynamic treatment system and a treatment method for tumors are invented, and the problem of limited irradiation range and depth is solved.
Disclosure of Invention
(one) solving the technical problems
Aiming at the defects of the prior art, the invention provides a photodynamic therapy system and a photodynamic therapy method for tumors, which solve the problem of limited irradiation range and depth.
(II) technical scheme
In order to achieve the above purpose, the invention is realized by the following technical scheme: a photodynamic therapy system for a tumor, comprising:
the system comprises a photosensitizer, a laser light source, a light transmission system, a monitoring and control system and a data recording and analyzing system, wherein the laser light source comprises a laser, a light emitting diode and an optical fiber light source, the light transmission system comprises a light guide, an optical fiber and a light guide pipe, and the monitoring and control system comprises an optical power meter, a photosensitizer concentration monitoring system, a temperature monitoring system and a control unit;
the data recording and analyzing system comprises data acquisition equipment, a data storage and management system and a data analysis and processing worker.
Preferably, the laser is a light source for generating highly focused, monochromatic and coherent light, can generate a laser beam with high energy and has higher light intensity and penetration depth, the structure of the laser comprises a laser medium, an optical resonant cavity and a pumping source, the light emitting diode converts electric energy into visible light, when current passes through the light emitting diode, electrons and holes are combined to release photons, the LED has lower power and light intensity and is suitable for photodynamic therapy with low energy, the optical fiber light source consists of a laser, an optical fiber and a coupler, and the laser generates light and transmits the light to a treatment area through the optical fiber.
Preferably, the photosensitizer is one of sodium aluminum phthalocyanine chloride, methyl-amrinone phenanthroline and dithiocarboxylic acid.
Preferably, the light guide has a high reflectivity internal surface to ensure minimal loss of light during transmission, and the optical fiber is an elongated flexible optical conductor for transmitting light generated by the light source to the treatment area. The optical fiber consists of one or more optical fibers consisting of a core with a high refractive index and a cladding with a low refractive index, and the light guide is made of a transparent material.
Preferably, the optical power meter monitors the stability of the light source and the accuracy of the output power, ensures the consistency and controllability of the light intensity in the treatment process, and the temperature monitoring system monitors the temperature change of the treatment area in real time. Thermal effects can occur during photodynamic therapy.
Preferably, the data acquisition device is used for acquiring various data generated in the treatment process, including light source output power, photosensitizer concentration, treatment area temperature and irradiation time, the data acquisition device is electrically connected with a sensor and a monitoring device, acquires the data in real time and transmits the data to the data recording and analyzing system, the data storage and management system is used for storing and managing the data acquired in the treatment process, and the data analyzing and processing tool extracts useful information and reveals relevance and trend in the treatment process by using statistical analysis, chart drawing and model establishment methods.
A method of photodynamic therapy of a tumour comprising the steps of: 7. a method of photodynamic therapy of a tumour, characterised by: the method comprises the following steps:
s1, before treatment, performing imaging scanning and tissue biopsy on a patient to determine the position, size and type of tumor, evaluating the physical condition and tumor characteristics of the patient, and determining whether photodynamic therapy is suitable;
s2, the photosensitizer is directly smeared on the surface of the tumor through local injection;
s3, selecting a proper laser or a light guide to guide light with a specific wavelength to a tumor area, and inserting a required number of optical fibers according to the requirement;
s4, monitoring the temperature, the optical power and the photosensitizer concentration of a treatment area in the treatment process, ensuring the safety and the effectiveness of treatment, adjusting and controlling the treatment when required, and deciding by a medical team according to real-time data;
s5, completing light irradiation treatment, performing wound treatment, pain management, subsequent care of anti-infective drugs and performing periodic follow-up visit and evaluation on patients to monitor treatment effects and treat any possible complications.
Preferably, the decision in S4 includes adjusting the light irradiation time and light power to achieve the optimal therapeutic effect.
(III) beneficial effects
The invention provides a photodynamic therapy system and a photodynamic therapy method for tumors. The beneficial effects are as follows:
the depth and the range of light transmission are increased by using the light guide capable of carrying a plurality of optical fibers, the optical fibers are inserted into a treatment area through the surface of the skin, the tail ends of the optical fibers can be placed near tumor tissues, so that the light of a light source can be transmitted to the tumor area, the irradiation of tumors is realized, reasonable light irradiation design is carried out according to the positions and the shapes of the tumors, and the problem of insufficient irradiation quantity of dead cancer cells of normal cells is avoided.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The embodiment of the invention provides a photodynamic therapy system for tumors, which comprises a photosensitizer, a laser light source, a light transmission system, a monitoring and control system and a data recording and analyzing system, wherein the laser light source comprises a laser, a light emitting diode and an optical fiber light source, the light transmission system comprises a light guide, an optical fiber and a light guide pipe, the monitoring and control system comprises a light power meter, a photosensitizer concentration monitoring system, a temperature monitoring system and a control unit, the laser is a light source for generating highly focused, monochromatic and coherent light, can generate a high-energy laser beam, has higher light intensity and penetration depth, the structure of the laser comprises a laser medium, an optical resonant cavity and a pumping source, the light emitting diode converts electric energy into visible light, and when current flows through the light emitting diode, electrons and holes are combined to release photons, the LED has lower power and light intensity, is suitable for low-energy photodynamic therapy, the optical fiber light source consists of a laser, an optical fiber and a coupler, the laser generates light, the light is transmitted to a treatment area through the optical fiber, the optical fiber light source has flexibility and controllability, the light can be guided to a narrow or hard-to-reach part, the optical fiber part of the optical fiber light source can be inserted into the treatment area through the skin surface, the tail end of the optical fiber can be placed near tumor tissue so as to transmit the light of the light source to the tumor area, the irradiation of the tumor is performed, the optical fiber light source is inserted under the skin or in the tissue in the operation, a light guide needle or a light guide tube is generally used for guiding the optical fiber, the light can be ensured to be accurately transmitted to a target area, the damage to surrounding tissues is avoided to the greatest extent, and the photosensitizer is sodium aluminum phthalocyanine, methyl-aminoprofilanthin, one of the dithiocarboxylic acids (DMSO), the light guide has a high reflectivity of the inner surface to ensure minimal loss of light during transmission, and the optical fiber is an elongated flexible optical conductor for transmitting light generated by the light source to the treatment area. The optical fiber consists of one or more optical fibers, the fibers consist of a core with a high refractive index and a cladding with a low refractive index, the optical pipe is made of transparent materials, the optical pipe is a flexible optical pipeline for transmitting light rays to a specific treatment area, the optical pipe has flexible and bendable characteristics, so that the light rays can flexibly reach a focus part, the inner diameter of the optical pipe is 1-2 times of the diameter of the optical fiber and is used for inserting a plurality of light rays, the optical power meter monitors the stability of a light source and the accuracy of output power, the consistency and the controllability of the light intensity in the treatment process are ensured, and the temperature monitoring system monitors the temperature change of the treatment area in real time. The control unit is used for controlling and regulating the light source, the light power and the light transmission system, the control unit is used for adjusting the light irradiation parameters in real time according to treatment requirements and monitoring results to ensure the accuracy and the effectiveness of photodynamic treatment, the data acquisition equipment is used for acquiring various data generated in the treatment process, including the light source output power, the photosensitizer concentration, the treatment area temperature and the irradiation time, the data acquisition equipment is electrically connected with the sensor and the monitoring equipment and acquires the data in real time and transmits the data to the data recording and analyzing system, the data storage and management system is used for storing and managing the data acquired in the treatment process, and the data analysis and processing tool uses statistical analysis, graph drawing and model establishment methods to extract useful information and reveal the relevance and trend in the treatment process.
The data recording and analyzing system comprises a data acquisition device, a data storage and management system and a data analysis and processing tool.
A method of photodynamic therapy of a tumour comprising the steps of: before treatment, the patient performs imaging scanning and tissue biopsy to determine the position, size and type of tumor, evaluates the physical condition and tumor characteristics of the patient, determines whether photodynamic therapy is suitable, S2, a photosensitizer is locally injected or directly smeared on the surface of the tumor, S3, a proper laser or a light guide is selected so as to guide light with specific wavelength to the tumor area, and a needed number of optical fibers are inserted according to needs, S4, the temperature, the optical power and the photosensitizer concentration of the treatment area are monitored during treatment, the safety and the effectiveness of the treatment are ensured, and regulation and control are performed when needed, a medical team makes decisions according to real-time data, the decisions in S4 comprise adjusting the light irradiation time and the optical power to achieve the optimal treatment effect, S5, completing the light irradiation treatment, performing wound treatment, pain management, subsequent care of anti-infective drugs and periodic follow-up and evaluation on the patient to monitor the treatment effect and treat any possible complications.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A photodynamic therapy system for a tumour, comprising:
the system comprises a photosensitizer, a laser light source, a light transmission system, a monitoring and control system and a data recording and analyzing system, wherein the laser light source comprises a laser, a light emitting diode and an optical fiber light source, the light transmission system comprises a light guide, an optical fiber and a light guide pipe, and the monitoring and control system comprises an optical power meter, a photosensitizer concentration monitoring system, a temperature monitoring system and a control unit;
the data recording and analyzing system comprises a data acquisition device, a data storage and management system and a data analysis and processing tool.
2. A photodynamic therapy system for tumours according to claim 1, wherein: the laser is a light source for generating highly focused, monochromatic and coherent light, the structure of the laser comprises a laser medium, an optical resonant cavity and a pumping source, the light emitting diode converts electric energy into visible light, and the optical fiber light source consists of the laser, an optical fiber and a coupler.
3. A photodynamic therapy system for tumours according to claim 1, wherein: the photosensitizer is one of sodium aluminum phthalocyanine chloride, methyl-amrinone phenanthroline and dithiocarboxylic acid.
4. A photodynamic therapy system for tumours according to claim 1, wherein: the light guide has a high reflectivity internal surface to ensure minimal loss of light during transmission, the optical fiber is an elongated flexible optical conductor, the light guide is made of a transparent material, and the light guide has an inner diameter 1-2 times the diameter of the optical fiber.
5. A photodynamic therapy system for tumours according to claim 1, wherein: the optical power meter monitors the stability of the light source and the accuracy of the output power, ensures the consistency and controllability of the light intensity in the treatment process, and the temperature monitoring system monitors the temperature change of the treatment area in real time, adjusts the light irradiation parameters in real time according to the treatment requirement and the monitoring result, and ensures the accuracy and the effectiveness of photodynamic treatment.
6. A photodynamic therapy system for tumours according to claim 1, wherein: the data acquisition equipment is electrically connected with a sensor and a monitoring equipment, acquires data in real time and transmits the data to the data recording and analyzing system, and the data analyzing and processing tool extracts useful information and reveals relevance and trend in the treatment process by using statistical analysis, chart drawing and model building methods.
7. A method of photodynamic therapy of a tumour, characterised by: the method comprises the following steps:
s1, before treatment, performing imaging scanning and tissue biopsy on a patient to determine the position, size and type of tumor, evaluating the physical condition and tumor characteristics of the patient, and determining whether photodynamic therapy is suitable;
s2, the photosensitizer is directly smeared on the surface of the tumor through local injection;
s3, selecting a proper laser or a light guide to guide light with a specific wavelength to a tumor area, and inserting a required number of optical fibers according to the requirement;
s4, monitoring the temperature, the optical power and the photosensitizer concentration of a treatment area in the treatment process, ensuring the safety and the effectiveness of treatment, adjusting and controlling the treatment when required, and deciding by a medical team according to real-time data;
s5, completing light irradiation treatment, performing wound treatment, pain management, subsequent care of anti-infective drugs and performing periodic follow-up visit and evaluation on patients to monitor treatment effects and treat any possible complications.
8. A method of photodynamic therapy of a tumour according to claim 7, wherein: the decision in S4 includes adjusting the light irradiation time and light power to achieve the optimal therapeutic effect.
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| CN202311608614.3A CN117462854A (en) | 2023-11-29 | 2023-11-29 | Photodynamic therapy system and method for tumor |
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| CN202311608614.3A CN117462854A (en) | 2023-11-29 | 2023-11-29 | Photodynamic therapy system and method for tumor |
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