CN117434285A - Sample injection module and sample analyzer - Google Patents

Sample injection module and sample analyzer Download PDF

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Publication number
CN117434285A
CN117434285A CN202210856758.XA CN202210856758A CN117434285A CN 117434285 A CN117434285 A CN 117434285A CN 202210856758 A CN202210856758 A CN 202210856758A CN 117434285 A CN117434285 A CN 117434285A
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China
Prior art keywords
sample
sample tube
tube
module
processing
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CN202210856758.XA
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Chinese (zh)
Inventor
肖华
梁国绿
胡彦勇
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Shenzhen Dymind Biotechnology Co Ltd
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Shenzhen Dymind Biotechnology Co Ltd
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Priority to CN202210856758.XA priority Critical patent/CN117434285A/en
Publication of CN117434285A publication Critical patent/CN117434285A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584Control arrangements for automatic analysers
    • G01N35/0092Scheduling
    • G01N35/0095Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/026Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having blocks or racks of reaction cells or cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009Characterised by arrangements for controlling the aspiration or dispense of liquids

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  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The application discloses advance kind module and sample analyzer, this advance kind module includes sample district, transfer mechanism, dispatch mechanism and at least one processing station. The sample area is used for placing a sample tube, and the sample tube is used for storing a sample; the transfer mechanism is used for transferring the sample tube; a plurality of sample tube positions are arranged along the extending direction of the dispatching mechanism, and the sample tubes are placed at the corresponding sample tube positions by the transferring mechanism; at least one processing station is arranged along the extending direction of the dispatching mechanism and is used for processing the sample tube positioned in the processing area; the scheduling mechanism selects a corresponding step size based on the operation instruction, and drives the sample tube based on the selected step size so as to enable the sample tube to be located in the processing area. The scheduling mechanism selects the corresponding step length to drive based on the operation instruction, and can directly schedule the sample tube when the requirement of the re-diagnosis or emergency treatment exists, the scheduling mechanism does not need to return and the like, the flow is simple, and the sample injection efficiency is improved.

Description

Sample injection module and sample analyzer
Technical Field
The application relates to the technical field of medical instruments, in particular to a sample injection module and a sample analyzer.
Background
In the field of medical devices, sample analyzers are generally used for detecting and analyzing samples such as blood samples and body fluids. The sample analyzer comprises a sample injection module, wherein the sample injection module is used for conveying a container loaded with a sample to a sample suction position so that the sample analyzer can suck the sample and perform detection analysis.
The existing sample injection module dispatches the sample frames loaded with a plurality of sample tubes, the sample frames are placed in the track sample injector to realize automatic sample injection, when the requirement of a re-diagnosis or an emergency call exists, the sample frames which are in sample injection are required to be returned to the back of a buffer area to wait for sample injection of the re-diagnosis or the emergency call, the dispatching flow is complex, and the sample injection efficiency of the sample injection module is affected.
Disclosure of Invention
The application provides a sample injection module and a sample analyzer to solve the technical problem of complicated intermediate flow in the prior art.
In order to solve the above problems, the present application provides a sample injection module, which includes a sample area, a transfer mechanism, a scheduling mechanism, and at least one processing station. The sample area is used for placing a sample tube, and the sample tube is used for storing a sample; the transfer mechanism is used for transferring the sample tube; a plurality of sample tube positions are arranged along the extending direction of the dispatching mechanism, and the transfer mechanism is used for placing the sample tubes at the corresponding sample tube positions; the at least one processing station is arranged along the extending direction of the dispatching mechanism and is used for processing the sample tubes in the processing area; the scheduling mechanism selects a corresponding step length based on an operation instruction, and drives the sample tube based on the selected step length so as to enable the sample tube to be located in the processing area.
The emergency treatment sample tube is arranged in a treatment area, and the emergency treatment sample tube is arranged in the treatment area.
When the sample tube to be reexamined is positioned on the scheduling mechanism, the scheduling mechanism selects a second step length based on the reexamined instruction and drives based on the second step length so that the sample tube is positioned in the processing area.
The operation instruction is a sample injection instruction, the scheduling mechanism selects a third step length based on the sample injection instruction, the third step length corresponds to the distance between two adjacent sample tube positions, and the scheduling mechanism drives based on the third step length so that the sample tube is located in the processing area.
The sample analyzer comprises a sample tube, a sample collecting position, a transfer mechanism and a control unit, wherein the at least one processing station comprises a sample collecting position and a recovery position, the sample collecting position is used for a sample analyzer to collect samples of the sample tube, and the transfer mechanism transfers the sample tube on the recovery position to the sample area for recovery; and when the scheduling mechanism is driven according to the third step length, the driving time of the scheduling mechanism from the sample sucking position to the recovery position is longer than the detection time of the sample analyzer for acquiring the detection data.
The dispatching mechanism comprises a dispatching disc, the plurality of sample tube positions are circumferentially arranged on the dispatching disc, and the dispatching disc can rotate around the axis direction of the dispatching disc so as to drive the sample tubes to the processing stations.
The dispatching mechanism comprises a transmission piece provided with a plurality of sample tube positions, and the shape of the transmission piece comprises a ring shape and a curve shape.
The transfer mechanism comprises a triaxial movement assembly and a clamping jaw, wherein the clamping jaw is used for clamping the sample tube, and the triaxial movement assembly is used for driving the clamping jaw to perform triaxial movement relative to the dispatching mechanism so that the clamping jaw can transfer the sample tube from the sample area to the dispatching mechanism or from the dispatching mechanism to the sample area.
The transfer mechanism clamps the sample tube by controlling the opening and closing degree of the clamping jaw, and the transmission mode of the clamping jaw comprises belt transmission, gear transmission, thread transmission and connecting rod transmission.
In order to solve the above problems, the present application provides a sample analyzer, including a sample injection module, a liquid separation module and a detection module as described above. The sample injection module is used for moving the sample tube to the processing station, wherein the processing station comprises a sample suction position; the liquid separation module is used for sucking samples of the sample tube positioned at the sample sucking position so as to obtain samples; the detection module is used for detecting the sample.
The sample analyzer further comprises a reagent module, wherein the reagent module is used for adding a reagent required by detection into the sample so as to prepare a reaction solution suitable for detection by the detection module; the detection module is also used for incubating the reaction liquid prepared by the sample so as to detect the incubated reaction liquid.
The application provides a sample introduction module and sample analyzer, this sample introduction module includes sample district, transfer mechanism, dispatch mechanism and at least one processing station. The sample area is used for placing a sample tube, and the sample tube is used for storing a sample; the transfer mechanism is used for transferring the sample tube; a plurality of sample tube positions are arranged along the extending direction of the dispatching mechanism, and the sample tubes are placed at the corresponding sample tube positions by the transferring mechanism; at least one processing station is arranged along the extending direction of the dispatching mechanism and is used for processing the sample tube positioned in the processing area; the scheduling mechanism selects a corresponding step size based on the operation instruction, and drives the sample tube based on the selected step size so as to enable the sample tube to be located in the processing area. The scheduling mechanism selects the corresponding step length to drive based on the operation instruction, and can directly schedule the re-diagnosis or emergency treatment sample tube when the re-diagnosis or emergency treatment needs exist, the scheduling mechanism does not need to return and other operations, the flow is simple, and the sample injection efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art. Wherein:
FIG. 1 is a schematic diagram of an embodiment of a sample injection module according to the present disclosure;
FIG. 2 is a schematic structural diagram of another embodiment of a sample injection module provided in the present application;
FIG. 3 is a schematic diagram of another embodiment of the scheduling mechanism of FIG. 1;
FIG. 4 is a schematic view of the transfer mechanism of FIG. 1;
FIG. 5 is a schematic view of the structure of the jaw of FIG. 4;
fig. 6 is a block diagram of an embodiment of a sample analyzer provided herein.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art without making any inventive effort, are intended to be within the scope of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and rear … …) are included in the embodiments of the present invention, the directional indications are merely used to explain the relative positional relationship, movement conditions, etc. between the components in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are correspondingly changed.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.
The application first provides a sample introduction module, and this sample introduction module is applied to a sample analyzer, and this sample analyzer is applicable to medical treatment or biochemical analysis field for carry out the autoinjection detection to the sample pipe that stores the sample. The sample analyzer may be a blood cell analyzer, a biochemical analyzer, an immunity analyzer, a blood coagulation analyzer, or other diagnostic equipment.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample injection module provided in the present application. As shown in fig. 1, the sample injection module 10 of the present embodiment includes a sample region 110, a transfer mechanism 210, a scheduling mechanism 310, and at least one processing station 410.
The sample area 110 is used for placing a sample tube for storing a sample. Specifically, when the sample injection module 10 performs sample injection, a user may place a sample rack with a sample tube placed therein or a sample carrying mechanism with multiple groups of sample racks placed therein in the sample area 110. The sample area 110 may be a sample injection area set by the sample analyzer, and a user may put the sample rack or the sample carrying mechanism into the sample injection area or unload the sample rack or the sample carrying mechanism from the sample injection area at any time during the detection process of the sample analyzer, so as to realize the non-stop loading or unloading of the sample analyzer and improve the detection speed of the sample analyzer.
Further, the sample rack may be a sample tube rack provided with a plurality of tube positions, and the sample carrying mechanism may be a mechanism for carrying a plurality of sample racks, for example, the sample carrying mechanism may be a basket in which a plurality of sample racks are placed. The sample bearing mechanism or the sample rack can be further provided with a handle, an anti-slip mark and the like which are easy for a user to operate and take and put, so that the use experience of the user is improved. The sample may be a blood sample, a urine sample, or a body fluid sample of the subject, and the sample type, the sample holder, and the sample carrying mechanism are not particularly limited herein.
The transfer mechanism 210 is used to transfer a sample tube, in particular, the transfer mechanism 210 is used to transfer a sample tube from the sample region 110 to the dispatch mechanism 310 or to transfer a sample tube from the dispatch mechanism 310 to the sample region 110. The transfer mechanism 210 may transfer the sample tube by clamping, rail transport, or the like.
The dispatch mechanism 310 is used to move a sample tube to a processing station 410. A plurality of sample tube positions 311 are provided along the extending direction of the dispatch mechanism 310, the sample tube positions 311 include accommodating chambers capable of accommodating sample tubes, and the transfer mechanism 210 places the sample tubes at the corresponding sample tube positions 311. The dispatching mechanism 310 can drive along the extending direction, and the sample tube is inserted into the sample tube position 311 and the position of the sample tube is changed along with the driving of the dispatching mechanism 310.
At least one processing station 410 is arranged along the extension of the scheduler 310, the processing station 410 being adapted to process sample tubes located in a processing area. Specifically, the processing station 410 is a position where the sample analyzer processes the sample tube on the dispatching mechanism 310, the sample analyzer can perform processes such as code scanning detection, sample sucking and recovery on the sample tube, and the processing station 410 can be disposed at any position of the dispatching mechanism 310. To increase the processing efficiency of the sample analyzer, the processing station 410 is secured to an area of the dispatch mechanism 310 such that the sample analyzer processes sample tubes located within the processing area.
After the transfer mechanism 210 places the sample tube into the dispatch mechanism 310, the dispatch mechanism 310 obtains an operation command corresponding to the sample tube, where the operation command includes, but is not limited to, a position, a number, and a sample injection mode of the sample tube. The scheduling mechanism 310 includes a power source for driving the transmission of the scheduling mechanism 310, the power source controlling the transmission distance of the scheduling mechanism 310 based on the step size. After receiving the operation instruction, the scheduling mechanism 310 selects a corresponding step size based on the operation instruction, and drives the sample tube based on the selected step size, so that the sample tube is located in the processing area. The step length is the pulse equivalent of the power source.
Further, the sample injection module 10 may be provided with a plurality of sample injection modes according to sample injection requirements of the sample analyzer. For example, the sample injection mode may include a regular sample injection mode in which the transfer mechanism 210 sequentially places the sample tubes into the sample tube positions 311 such that the dispatch mechanism 310 sequentially drives the sample tubes into the processing region according to the order of the sample tube positions 311; in emergency and/or re-diagnosis sample mode, the dispatch mechanism 310 directly drives the emergency and/or re-diagnosis sample tubes into the processing area in order to facilitate the sample analyzer to preferentially detect the sample tubes in need of emergency and/or re-diagnosis.
In this embodiment, the sample area 110 of the sample injection module 10 is used for placing a sample tube, and the sample tube is used for storing a sample; the transfer mechanism 210 is used for transferring the sample tube; a plurality of sample tube positions 311 are arranged along the extending direction of the dispatching mechanism 310, and the transfer mechanism 210 places the sample tubes at the corresponding sample tube positions 311; at least one processing station 410 is arranged along the extension direction of the dispatching mechanism 310 for processing the sample tubes located in the processing region; the scheduler 310 selects a corresponding step size based on the operation instruction and drives the sample tube based on the selected step size to locate the sample tube within the processing region. The scheduling mechanism 310 of the embodiment selects the corresponding step length to drive based on the operation instruction, and when there is a requirement for a review or emergency, the scheduling mechanism 310 can directly schedule the sample tube for the review or emergency, the sample injection module 10 does not need to return the sample tube being detected, the flow is simple, and the improvement of the sample injection efficiency is facilitated.
Optionally, the sample injection module 10 further includes a detection mechanism, where the detection mechanism is disposed in the sample area 110 and is used for detecting whether the sample rack or the sample carrying mechanism of the sample area 110 is in place, and the detection mechanism is further used for acquiring whether the sample rack or the sample carrying mechanism of the sample area 110 has information, so that a user can load, unload or adjust the sample according to whether the sample rack or the sample carrying mechanism of the detection mechanism has information, and the use experience of the user is improved.
Optionally, the operation instruction is an emergency instruction, where the emergency instruction includes a position, number, etc. of sample tubes, the sample injection module 10 marks the sample tube with an emergency requirement as an emergency sample tube, the transfer mechanism 210 stops the current transfer operation, and the dispatch mechanism 310 stops the current dispatch operation, so that the transfer mechanism 210 and the dispatch mechanism 310 preferentially transfer the emergency sample tube into the processing area.
Specifically, the user places the emergency sample tube in the sample area 110, and the transfer mechanism 210 is configured to place the emergency sample tube in a preset sample tube position 311, where the preset sample tube position 311 may be a sample tube position 311 in a preset area on the dispatching mechanism 310, or may be an idle sample tube position 311 in an area of the dispatching mechanism 310 near one side of the transfer mechanism 210. The scheduling mechanism 310 selects a first step size based on the emergency instruction and drives based on the first step size, wherein the first step size is a step size that the scheduling mechanism 310 moves the sample tube from the preset sample tube position 311 to the processing station 410. The emergency sample tube moves with the drive of the dispatch mechanism 310 such that the emergency sample tube is located within the processing region.
During normal sample injection, the transfer mechanism 210 sequentially places a plurality of sample tubes in the scheduling mechanism 310, and the scheduling mechanism 310 sequentially transmits the sample tubes to the processing area, and at this time, the scheduling mechanism 310 performs transmission according to a first preset direction. When the sample injection module 10 receives the emergency instruction, the transfer mechanism 210 places the emergency sample tube at the preset sample tube position 311, and the scheduling mechanism 310 drives the emergency sample tube into the processing area along the first preset direction or along a second preset direction opposite to the first preset direction. The direction in which the dispatch mechanism 310 drives the emergency sample tubes is related to the position of the processing station 410 and the preset relative position of the sample tube position 311, and is not specifically limited herein.
Wherein the first preset direction and the second preset direction may be a clockwise direction or a counterclockwise direction. For example, the first preset direction is clockwise, and the second preset direction is counterclockwise; or the first preset direction is a counterclockwise direction, and the second preset direction is a clockwise direction.
In this embodiment, the operation instruction is an emergency instruction, the transfer mechanism 210 is configured to place the emergency sample tube at a preset sample tube position 311, and the scheduling mechanism 310 selects a first step size based on the emergency instruction and performs transmission based on the first step size, so that the emergency sample tube is located in the processing area. When an emergency call is required, the dispatching mechanism 310 of the embodiment can directly dispatch the emergency call sample tube based on the emergency call instruction, and the flow is simple, which is beneficial to improving the sampling efficiency.
Optionally, when the data detected by the sample analyzer is abnormal, the sample analyzer needs to re-diagnose the abnormal sample tube so as to ensure the accuracy of the data; at this time, the operation instruction is a review instruction. After receiving the re-diagnosis instruction, the sample injection module 10 obtains the position of the sample tube to be re-diagnosed, and correlates the position of the sample tube to be re-diagnosed with the re-diagnosis instruction, the transfer mechanism 210 stops the current transfer operation, and the scheduling mechanism 310 stops the current scheduling operation, so that the sample analyzer preferentially detects the sample tube to be re-diagnosed.
Specifically, when the sample tube to be re-diagnosed is located on the scheduling mechanism 310, the scheduling mechanism 310 selects a second step length based on the re-diagnosis instruction, and performs transmission based on the second step length, so that the sample tube is located in the processing area. Wherein the second step size is the step size of the scheduling mechanism 310 moving the sample tube to be re-diagnosed from the current sample tube position 311 to the processing station 410.
During routine sample injection, the transfer mechanism 210 sequentially places a plurality of sample tubes in the dispatching mechanism 310, the dispatching mechanism 310 sequentially transfers the sample tubes into the processing area, and at this time, the dispatching mechanism 310 drives in a first preset direction. When the sample injection module 10 receives the review instruction and confirms that a certain sample tube on the dispatching mechanism 310 needs to be reviewed, the dispatching mechanism 310 rotates to retransmit the sample tube into the processing region along a second preset direction opposite to the first preset direction, so that the processing station 410 processes the sample tube to be reviewed located in the processing region preferentially. After the review is finished, the sample injection module 10 continues to execute the detection process which is suspended before.
In this embodiment, the operation instruction is a review instruction, and when the sample tube to be reviewed is located on the scheduling mechanism 310, the scheduling mechanism 310 selects a second step length based on the review instruction, and performs transmission based on the second step length, so that the sample tube is located in the processing area. The scheduling mechanism 310 of the embodiment can directly schedule the sample tube to be re-diagnosed based on the re-diagnosis instruction, and has simple flow and is beneficial to improving the sampling efficiency.
Optionally, the operation instruction is a sample injection instruction, the scheduling mechanism 310 selects a third step size based on the sample injection instruction, and the scheduling mechanism 310 drives based on the third step size so that the sample tube is located in the processing area.
Specifically, during routine sample injection, the sample injection module 10 receives a sample injection instruction, the transfer mechanism 210 sequentially places a plurality of sample tubes on the sample tube positions 311 of the scheduling mechanism 310, and the scheduling mechanism 310 sequentially transfers the sample tubes into the processing region based on the third step size. Wherein the third step corresponds to the distance between two adjacent sample tube bits 311; when the sample tubes in the processing region are processed, the scheduler 310 advances the sample tube position 311 one position in the first preset direction based on the third step transmission once, so that the sample tubes adjacent to the processed sample tubes enter the processing region, and the sample tubes enter the processing station 410 in sequence. At this time, the distance by which the scheduler 310 drives once corresponds to the distance between two adjacent sample tube positions 311.
In this embodiment, the operation instruction is a sample injection instruction, the scheduling mechanism 310 selects a third step length based on the sample injection instruction, and the third step length is a distance between two adjacent sample tube positions 311, and the scheduling mechanism 310 performs transmission based on the third step length, so that the sample tube is located in the processing area. The dispatching mechanism 310 of the embodiment sequentially drives the sample tubes of the sample tube positions 311 into the processing area, no auxiliary parts are needed for positioning, and the structure is simple and easy to realize.
Optionally, the at least one processing station 410 includes a sample sucking position 411 and a recovering position 412, the sample sucking position 411 is used for a sample analyzer to suck samples stored in the sample tubes, the dispatching mechanism 310 drives the sample tubes after sucking the samples into the region of the recovering position 412, and the transferring mechanism 210 transfers the sample tubes on the recovering position 412 to the sample region 110 for recovering. For example, sample tube position 311 on scheduler 310 is provided with a number, and scheduler 310 drives the sample tube in the first position to sample suction position 411 and drives the sample tube in the first position to recovery position 412.
When the dispatching mechanism 310 drives according to the third step length, the driving time of the dispatching mechanism 310 from the sample sucking position 411 to the recovering position 412 is longer than the detection time of the sample analyzer for obtaining the detection data; or, the time for the dispatching mechanism 310 to drive the sample tube at the first position from the sample sucking position 411 to the recovering position 412 is longer than the detection time for the sample analyzer to acquire detection data; or, a preset number of sample tube positions 311 exist between the sample suction position 411 and the recovery position 412, and the time for the scheduling mechanism 310 to drive the sample tubes based on the third step length and pass through the preset number of sample tube positions 311 is longer than the detection time for the sample analyzer to acquire detection data.
Specifically, the sample suction site 411 and the recovery site 412 may be provided at any position of the dispatch mechanism 310. After the sample analyzer performs a sample sucking operation on the sample tube of the sample sucking position 411, the sample analyzer adds a reaction reagent required for detection into the sample to prepare the sample into a reaction liquid suitable for detection by the sample analyzer, and the sample analyzer detects the reaction liquid to obtain detection data. The time for the sample analyzer to acquire the detection data is the time required for the sample analyzer to prepare the reaction liquid and detect the reaction liquid.
After the sample analyzer acquires the detection data, judging whether the detection data of the sample tube is abnormal, and executing a re-diagnosis process on the sample tube by the sample analyzer when the detection data of the sample tube is abnormal; or, in the process of preparing the reaction liquid and detecting, sample loss, pollution and the like occur due to abnormal operation of the sample analyzer, and the sample analyzer executes a re-diagnosis flow on the sample tube; because the transmission time of the dispatching mechanism 310 from the sample sucking position 411 to the recovering position 412 is longer than the detection time of the sample analyzer for acquiring the detection data, when the sample tube needs to be subjected to the re-diagnosis, the sample tube is ensured to be still positioned on the dispatching mechanism 310, so that the sample injection module 10 can conveniently perform the re-diagnosis operation.
In this embodiment, the at least one processing station 410 includes a sample sucking position 411 and a recovering position 412, the sample sucking position 411 is used for a sample analyzer to suck samples stored in a sample tube, the transferring mechanism 210 transfers the sample tube on the recovering position 412 to the sample area 110 for recovering, and when the scheduling mechanism 310 is driven according to the third step, the driving time of the scheduling mechanism 310 from the sample sucking position 411 to the recovering position 412 is longer than the detection time of the sample analyzer to obtain the detection data. By the method of the embodiment, when the re-diagnosis is required, the sample tube is positioned on the dispatching mechanism 310, so that the sample injection module 10 can perform the re-diagnosis operation, and the re-diagnosis efficiency is improved.
Optionally, the sample area 110 is used for placing a sample tube. During sample injection, a user places a plurality of groups of sample racks in the sample area 110, the transfer mechanism 210 transfers sample tubes on the sample racks to the scheduling mechanism 310, the scheduling mechanism 310 moves the sample tubes to the sample absorbing position 411 so that the sample analyzer can absorb samples of the sample tubes, the scheduling mechanism 310 continues to move the sample tubes to the recovery position 412, and the transfer mechanism 210 transfers the sample tubes on the recovery position 412 to the sample racks in the sample area 110, which are injected simultaneously with the sample tubes, so as to complete the sample injection operation.
Because the loading position and the unloading position of the sample tube are the sample frames on the sample area 110, the sample injection module 10 does not need to set a loading area and an unloading area, so that the dispatching process of loading and unloading the sample injection module 10 is reduced, a user can place the sample frames at any position of the sample area 110, and the use experience of the user is improved; and the free area of the sample area 110 can be used as a reloading area or an unloading area, which is beneficial to expanding the sample capacity by expanding the area of the sample area 110.
Optionally, to improve the efficiency of transferring the sample tubes by the transfer mechanism 210, the recycling area of the recycling position 412 is located on a side of the dispatching mechanism 310 close to the transfer mechanism 210, and a conventional sample feeding area for placing the sample tubes by the transfer mechanism 310 on the dispatching mechanism 310 and an emergency sample feeding area for placing the sample tubes by the transfer mechanism 210 under a sample feeding instruction are provided on a side of the dispatching mechanism 310 close to the transfer mechanism 210, where the sample feeding module 10 places the sample tubes by the transfer mechanism 210 under the emergency instruction.
In one embodiment, the location of the regular sample injection area and the emergency sample injection area are fixed, and the emergency sample injection area is located between the regular sample injection area and the recovery location 412. For example, during routine sampling, the dispatching mechanism 310 is driven along a first preset direction, and the side of the dispatching mechanism 310, which is close to the transferring mechanism 210, is sequentially provided with a recycling position 412, an emergency sampling area and a routine sampling area along the first preset direction.
Further, a position detector can be arranged on the emergency sample injection area, and the position detector is used for acquiring whether an emergency sample tube is placed on the emergency sample injection area. Due to the fixed location of the emergency sample injection area, the dispatch mechanism 310 directly drives based on the first step size when the emergency sample tube is placed in the emergency sample injection area. In other embodiments, the location of the emergency sample area is not fixed, the dispatch mechanism 310 obtains location information of the emergency sample tube on the dispatch mechanism 310, and selects the first step size based on the emergency instructions and the location information.
Optionally, the at least one processing station 410 may further comprise an information reading bit for obtaining sample information of the sample tube to correlate the sample information of the sample tube with the detection data of the sample.
Specifically, the information reading bit may be provided with a code scanner, a barcode is adhered on the sample tube, information on the barcode corresponds to personal information of a person to be tested, a detection item and the like, and before the sample analyzer performs a sample sucking operation on the sample tube, the sample analyzer needs to obtain sample information of the sample tube. For example, the transfer mechanism 210 places the sample tube in the dispatch mechanism 310, the dispatch mechanism 310 transfers the sample tube to the information reading station, transfers the sample tube to the sample suction station 411, and transfers the sample tube to the recovery station 412 to recover the sample tube.
In other embodiments, the information reading bit may be disposed at other positions of the sample module 10, for example, the transfer mechanism 210 transfers the sample tube to the information reading bit before the sample tube is placed at the sample tube position 311, and after the scanner of the information reading bit obtains the information of the sample tube, the transfer mechanism 210 places the sample tube at the sample tube position 311.
Referring to fig. 2, fig. 2 is a schematic structural diagram of another embodiment of a sample injection module provided in the present application. As shown in fig. 2, the dispatching mechanism 310 includes a dispatching disk 312, and a plurality of sample tube positions 311 are sequentially arranged along the circumferential direction of the dispatching disk 312, and the dispatching disk 312 can rotate around its own axis direction to drive the sample tubes to the processing stations 410.
Specifically, the dispatch plate 312 is a disk provided with a plurality of sample tube positions 311, the plurality of sample tube positions 311 are located on the same circumferential cross section of the dispatch plate 312, and the dispatch plate 312 rotates based on the first step size, the second step size or the third step size to drive the sample tubes to the processing station 410. The diameter of the dial 312 is related to the number of sample tube bits 311. The dispatching mechanism 310 further comprises a power source, and the power source drives the dispatching disk 312 to rotate through a transmission member such as a belt or a gear.
Referring to fig. 3, fig. 3 is a schematic structural diagram of another embodiment of the scheduling mechanism in fig. 1. As shown in fig. 3, the dispatching mechanism 310 includes a driving member 313 provided with a plurality of sample tube positions 311, and the shape of the driving member 313 includes a ring shape and a curve shape.
Specifically, the transmission member 313 includes, but is not limited to, a chain or ring such as a transmission chain or a conveying chain, the transmission member 313 is fixed with a plurality of container bases, the container bases are provided with sample tube positions 311, and the transmission member 313 can drive the container bases to rotate relatively so as to transmit the sample tubes of the sample tube positions 311 to the processing station 410. As shown in fig. 1, in one embodiment, the transmission member 313 is annular in shape; in another embodiment, as shown in fig. 3, the shape of the transmission member 313 is curved.
Alternatively, in an embodiment, the plurality of sample tube bits 311 are equally spaced on the transmission member 313, and the scheduling mechanism 310 may track and position the sample tubes according to the spacing between two adjacent sample tube bits 311. In another embodiment, the intervals between the sample tube positions 311 on the transmission member 313 are not equal, and in this case, the scheduling mechanism 310 is further provided with a blocking member and a positioning member to position the sample tube positions.
Referring to fig. 4, fig. 4 is a schematic structural view of the transfer mechanism in fig. 1. As shown in fig. 4, transfer mechanism 210 includes a tri-axial motion assembly 211 and a jaw 220, jaw 220 being configured to grip a sample tube, tri-axial motion assembly 211 being configured to drive jaw 220 in tri-axial motion relative to dispatch mechanism 310 such that jaw 220 transfers a sample tube from sample region 110 to dispatch mechanism 310 or from dispatch mechanism 310 to sample region 110.
Specifically, triaxial movement assembly 211 includes a first movement member 213, a second movement member 214, and a third movement member 215, wherein first movement member 213 is used for driving jaw 220 to move in the X direction, second movement member 214 is used for driving jaw 220 to move in the Y direction, and third movement member 215 is used for driving jaw 220 to move in the Z direction. The triaxial motion assembly 211 may be driven by a power source such as a motor or a cylinder, or may be driven by a transmission assembly such as a belt, a screw, a rack and pinion.
The clamping jaw 220 is disposed on the third moving member 215, the clamping jaw 220 is used for clamping a sample tube, the clamping function of the clamping jaw 220 can be realized by an elastic clamping jaw or a power clamping jaw, the power clamping jaw is an active open-close clamping jaw, and the power source of the power clamping jaw comprises but is not limited to a motor, a cylinder, an electromagnet and the like.
Referring to fig. 5, fig. 5 is a schematic structural diagram of the clamping jaw in fig. 4. As shown in fig. 5, when the clamping jaw 220 is a power clamping jaw, the transfer mechanism 210 clamps the sample tube by controlling the opening and closing degree of the clamping jaw 220, and the transmission modes of the clamping jaw 220 include belt transmission, gear transmission, thread transmission and link transmission. The degree of opening and closing of the jaws 220 may be controlled by an optical sensor, a magnetic switch, etc.
Specifically, the clamping jaw 220 includes a first clamping end 221 and a second clamping end 222, the first clamping end 221 and the second clamping end 222 move toward each other to clamp the sample tube, and the first clamping end 221 and the second clamping end 222 move away from each other to release the sample tube. The relative movement of the first and second clamping ends 221, 222 may be accomplished by way of a drive belt 223 (shown in fig. 5-a), a gear 224 and rack 225 (shown in fig. 5-b), threads (shown in fig. 5-c), a link 226 (shown in fig. 5-d), and the like.
Referring to fig. 6, fig. 6 is a frame diagram of an embodiment of a sample analyzer provided in the present application. As shown in fig. 6, the present application also provides a sample analyzer for analyzing and measuring a sample of blood, urine, or the like. The sample analyzer comprises a sample introduction module 10, a liquid separation module 20 and a detection module 30 as described in any of the embodiments above.
The sample introduction module 10 is used for moving the sample tube to a processing station 410, wherein the processing station 410 comprises a sample suction position 411; the liquid separation module 20 is used for sucking samples from the sample tube positioned at the sample sucking position 411 to obtain samples; the detection module 30 is used for detecting the sample.
Optionally, the sample analyzer further includes a reagent module 40, the liquid separation module 20 is connected to the reagent module 40, and the reagent module 40 is used for adding a reagent required for detection to the sample, so as to prepare a reaction liquid suitable for detection by the detection module 30; the detection module 30 is further used for incubating a reaction solution prepared by a sample, so as to detect the reaction solution after the incubation is completed.
Optionally, the sample analyzer further includes a reaction module, on which a plurality of cup positions for carrying reaction cups are disposed, and after the liquid separation module 20 sucks the sample, the sample is injected into the reaction cups, and the liquid separation module 20 quantitatively sucks and separates the reagent stored in the reagent module 40 into the reaction cups, so that the sample in the reaction cups reacts with the reagent to obtain a reaction liquid; the detection module 30 heats and incubates the reaction liquid, and detects the incubated reaction liquid to obtain detection data.
The foregoing description is only of embodiments of the present application, and is not intended to limit the scope of the patent application, and all equivalent structures or equivalent processes using the descriptions and the contents of the present application or other related technical fields are included in the scope of the patent application.

Claims (11)

1. A sample introduction module, comprising:
a sample area for placing a sample tube for storing a sample;
a transfer mechanism for transferring the sample tube;
the transfer mechanism is used for placing the sample tubes at the corresponding sample tube positions;
at least one processing station arranged along the extending direction of the dispatching mechanism and used for processing the sample tube positioned in the processing area;
the scheduling mechanism selects a corresponding step length based on an operation instruction, and drives the sample tube based on the selected step length so that the sample tube is located in the processing area.
2. The sample injection module of claim 1, wherein the operation instruction is an emergency instruction, the transfer mechanism is configured to place an emergency sample tube at a preset sample tube position, and the scheduling mechanism selects a first step size based on the emergency instruction and performs transmission based on the first step size so that the emergency sample tube is located in the processing area.
3. The sample injection module of claim 1, wherein the operating instruction is a review instruction, and wherein when the sample tube to be reviewed is located on the scheduling mechanism, the scheduling mechanism selects a second step size based on the review instruction and drives based on the second step size so that the sample tube is located within the processing region.
4. A sample injection module according to any one of claims 2 to 3, wherein the operation instruction is a sample injection instruction, the scheduling mechanism selects a third step length based on the sample injection instruction, the third step length corresponds to a distance between two adjacent sample tube positions, and the scheduling mechanism performs transmission based on the third step length so that the sample tube is located in the processing region.
5. The sample injection module of claim 4, wherein the at least one processing station comprises a sample suction station and a recovery station, the sample suction station is used for a sample analyzer to suck the sample tube, and the transfer mechanism transfers the sample tube on the recovery station to the sample area for recovery; and when the scheduling mechanism is driven according to the third step length, the driving time of the scheduling mechanism from the sample sucking position to the recovery position is longer than the detection time of the sample analyzer for acquiring the detection data.
6. The sample injection module of claim 1, wherein the dispatch mechanism comprises a dispatch disc circumferentially provided with the plurality of sample tube locations, the dispatch disc rotatable about its own axis to transfer the sample tubes to the processing stations.
7. The sample introduction module of claim 1, wherein the scheduling mechanism comprises a transmission member provided with the plurality of sample tube positions, the transmission member having a shape comprising a ring shape and a curve shape.
8. The sample injection module of any one of claims 6-7, wherein the transfer mechanism comprises a tri-axial motion assembly for gripping the sample tube and a jaw for driving the jaw in tri-axial motion relative to the dispatch mechanism to cause the jaw to transfer the sample tube from the sample region to the dispatch mechanism or from the dispatch mechanism to the sample region.
9. The sample injection module of claim 8, wherein the transfer mechanism clamps the sample tube by controlling the degree of opening and closing of the clamping jaw, and the clamping jaw is driven by a belt drive, a gear drive, a thread drive or a connecting rod drive.
10. A sample analyzer, comprising:
the sample introduction module of any one of claims 1-9 for moving the sample tube to the processing station, wherein the processing station comprises a sample suction station;
the liquid separation module is used for sucking samples of the sample tube positioned at the sample sucking position so as to obtain samples;
and the detection module is used for detecting the sample.
11. The sample analyzer of claim 10, further comprising a reagent module for adding reagents required for detection to the sample to prepare a reaction solution suitable for detection by the detection module; the detection module is also used for incubating the reaction liquid prepared by the sample so as to detect the incubated reaction liquid.
CN202210856758.XA 2022-07-12 2022-07-12 Sample injection module and sample analyzer Pending CN117434285A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210856758.XA CN117434285A (en) 2022-07-12 2022-07-12 Sample injection module and sample analyzer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210856758.XA CN117434285A (en) 2022-07-12 2022-07-12 Sample injection module and sample analyzer

Publications (1)

Publication Number Publication Date
CN117434285A true CN117434285A (en) 2024-01-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210856758.XA Pending CN117434285A (en) 2022-07-12 2022-07-12 Sample injection module and sample analyzer

Country Status (1)

Country Link
CN (1) CN117434285A (en)

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