CN117434041A - Parathyroid gland identification device and identification method thereof - Google Patents
Parathyroid gland identification device and identification method thereof Download PDFInfo
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- CN117434041A CN117434041A CN202311383640.0A CN202311383640A CN117434041A CN 117434041 A CN117434041 A CN 117434041A CN 202311383640 A CN202311383640 A CN 202311383640A CN 117434041 A CN117434041 A CN 117434041A
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- 210000002990 parathyroid gland Anatomy 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 8
- 230000005284 excitation Effects 0.000 claims abstract description 30
- 230000003287 optical effect Effects 0.000 claims abstract description 25
- 230000000849 parathyroid Effects 0.000 claims abstract description 23
- 238000001914 filtration Methods 0.000 claims abstract description 17
- 238000012545 processing Methods 0.000 claims abstract description 14
- 239000000523 sample Substances 0.000 claims abstract description 8
- 238000001228 spectrum Methods 0.000 claims description 13
- 239000002131 composite material Substances 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 7
- 239000013307 optical fiber Substances 0.000 description 5
- 210000001685 thyroid gland Anatomy 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 208000024799 Thyroid disease Diseases 0.000 description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 description 2
- 238000013480 data collection Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 206010020850 Hyperthyroidism Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 201000005895 multinodular goiter Diseases 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/06—Measuring instruments not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/373—Surgical systems with images on a monitor during operation using light, e.g. by using optical scanners
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The invention discloses a parathyroid gland identification device which comprises an excitation light module, an optical probe, a light filtering module, a data acquisition module, a data co-processing module, a camera shooting handle, a main control module and a display module. The optical filtering module comprises a slit, a reflecting mirror, a first plano-concave reflecting mirror, a plane line reflection type grating, a second plano-concave reflecting mirror and a photoelectric detector. The excitation light and parathyroid fluorescent signals are separated in space position through the optical filtering module, the influence of interference light is reduced, the photoelectric detector is controlled by the stepper motor combined with the reflecting mirror in the optical filtering module to receive optical signals with different wavelengths, single-wavelength detection or scanning detection of 820nm to 1100nm wave bands can be realized, and the interference of the excitation light is thoroughly eliminated.
Description
Technical Field
The invention relates to the technical field of biological tissue identification, in particular to a parathyroid gland identification device and an identification method thereof.
Background
The incidence of global thyroid diseases is rapidly rising, and the incidence of some provincial thyroid cancers in China has entered the first ten of malignant tumors. Thyroidectomy is a common surgical procedure for removing all or part of the thyroid gland, and is used to treat thyroid disorders, including thyroid cancer, hyperthyroidism and multinodular goiter. Parathyroid gland is gland of soybean size on thyroid gland, which plays an important role in regulating blood calcium, and serious complications can be caused by miscut in operation, if miscut is judged by pathological section, doctor needs to execute autograft in time.
The parathyroid glands have been found to fluoresce 2 to 10 times more than surrounding tissue under laser irradiation. Based on the principle, the position of the parathyroid gland can be judged by comparing the fluorescence intensity generated by the parathyroid gland excitation with the fluorescence intensity generated by the thyroid gland excitation, and miscut is prevented, so that the purpose of positioning the parathyroid gland and the thyroid gland is realized. The existing research mainly comprises the steps that excitation light enters from one end of an optical fiber through a y-shaped optical fiber, exits from a probe and irradiates on tissues, and excited fluorescence enters the optical fiber through the probe and exits from the other end of the optical fiber to a photoelectric detector with an optical filter. Because the excitation light itself is reflected at the tissue surface, the reflected excitation light and the excited fluorescence enter the photodetector 306 together through the optical fiber, and even after the excitation light is filtered through the optical filter with a deeper cut-off depth, part of the reflected excitation light still enters the photodetector, so that the detection of the weak parathyroid fluorescent signal can be interfered.
Disclosure of Invention
This section is intended to outline some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section as well as in the description summary and in the title of the application, to avoid obscuring the purpose of this section, the description summary and the title of the invention, which should not be used to limit the scope of the invention.
In order to solve the technical problems, according to one aspect of the present invention, the following technical solutions are provided:
the parathyroid recognition device comprises an excitation light module, an optical probe, a light filtering module, a data acquisition module, a data co-processing module, a camera shooting handle, a main control module and a display module.
As a preferable scheme of the parathyroid recognition device, the filtering module comprises a slit, a reflecting mirror, a first plano-concave reflecting mirror, a plane line-dividing reflecting grating, a second plano-concave reflecting mirror and a photoelectric detector, wherein the composite light beam is collimated by the first plano-concave reflecting mirror and becomes parallel light after passing through the slit to limit the aperture angle of incident light, and is reflected by the reflecting mirror and then passes through the reflecting device plane line-dividing reflecting grating to generate different diffraction angles according to different wavelengths, and the different light beams are incident on the second plano-concave reflecting mirror at different incident angles, and are distributed at different spatial positions and enter the photoelectric detector.
As a preferable mode of the parathyroid identifying device, the photoelectric detector is an APD avalanche photodiode.
As a preferable mode of the parathyroid identifying device, the reflecting mirror is a laser vibrating mirror or a DMD reflecting mirror.
As a preferable mode of the parathyroid gland recognition device, the data acquisition module comprises an operational amplifier and a stepping motor, and the stepping motor is used for controlling the position of the photoelectric detector so as to measure signals of different spatial positions.
As a preferable mode of the parathyroid identifying device, the wavelength of the excitation light is 785nm, and the wavelength of the light signal to be acquired is 820nm to 1100nm.
As a preferable mode of the parathyroid identifying device, the focal length of the first plano-concave reflecting mirror is 50mm, and the focal length of the second plano-concave reflecting mirror is 100mm.
As a preferable mode of the parathyroid identifying device of the present invention, the line pair number of the planar reticle reflection type grating is 300 lines/mm.
As a preferable scheme of the parathyroid gland recognition device, the data acquisition mode of the data acquisition module can be single-point acquisition or scanning acquisition, the single-point acquisition mode is used for fixing the angle of a laser vibrating mirror or a DMD (digital micromirror device) reflector, a stepping motor is controlled to acquire 830nm spectrum data, the scanning acquisition mode is used for controlling the angle of the laser vibrating mirror or the DMD reflector, and the position of a photoelectric detector is fixed, so that the spectrum of 830-1100nm periodically falls into the photoelectric detector, and the spectrum data of a target to be detected is obtained.
Compared with the prior art, the invention has the following beneficial effects: the excitation light and parathyroid fluorescent signals are separated in space position through the optical filtering module, the influence of interference light is reduced, the photoelectric detector is controlled by the stepper motor combined with the reflecting mirror in the optical filtering module to receive optical signals with different wavelengths, single-wavelength detection or scanning detection of 820nm to 1100nm wave bands can be realized, and the interference of the excitation light is thoroughly eliminated.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following detailed description will be given with reference to the accompanying drawings and detailed embodiments, it being obvious that the drawings in the following description are only some embodiments of the present invention, and that other drawings may be obtained from these drawings without inventive faculty for a person skilled in the art. Wherein:
FIG. 1 is a schematic diagram of a system configuration of a parathyroid recognition device in accordance with the present invention;
FIG. 2 is a schematic view of a filtering module of a parathyroid recognition device according to the present invention;
FIG. 3 is a spatial distribution diagram of 785.+ -.10 nm excitation light and 820nm fluorescence light of a parathyroid recognition device of the present invention after passing through a spectroscopic system;
fig. 4 is a schematic structural diagram of a data acquisition module of the parathyroid recognition device of the present invention.
Detailed Description
In order that the above objects, features and advantages of the invention will be readily understood, a more particular description of the invention will be rendered by reference to the appended drawings.
Next, the present invention will be described in detail with reference to the drawings, wherein the sectional view of the device structure is not partially enlarged to general scale for the convenience of description, and the drawings are only examples, which should not limit the scope of the present invention. In addition, the three-dimensional dimensions of length, width and depth should be included in actual fabrication.
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, embodiments of the present invention will be described in further detail below with reference to the accompanying drawings.
Fig. 1 to 4 are schematic views showing the overall structure of an embodiment of a parathyroid recognition device according to the present invention, referring to fig. 1 to 4, a parathyroid recognition method and device according to the present embodiment includes an excitation light module 10, an optical probe 20, a light filtering module 30, a data acquisition module 40, a data co-processing module 50, a camera handle 60, a main control module 70 and a display module 80.
Further, the data acquisition module 40 includes: operational amplifier, stepper motor 402, photodetector 306 is fixed on stepper motor 402, stepper motor 402 is used to control the position of photodetector 306, thereby measuring signals at different spatial positions
Further, the mirror 302 may be a laser galvanometer or DMD mirror 302.
Further, the filtering module 30 includes a slit 301, a mirror 302, a first plano-concave mirror 303, a planar reticle reflection grating 304, and a second plano-concave mirror 305, where the aperture angle of the incident light is limited by the slit, the composite light beam is collimated by the first plano-concave mirror 303 and then becomes parallel light, and is reflected by the mirror 302 and then is incident on the second plano-concave mirror 305 at different incident angles by generating different diffraction angles according to different wavelengths by the planar reticle reflection grating 304 of the reflecting device, and the light beams with different wavelengths are distributed at different spatial positions.
In this embodiment, the excitation light and the parathyroid fluorescent signal are separated in space position by the optical filtering module 30, so that the influence of the interference light is reduced, the step motor 402 is combined with the reflecting mirror 302 in the optical filtering module 30 to control the photoelectric detector to receive the optical signals with different wavelengths, so that the scanning detection of the signals with the wave bands of 820nm to 1100nm can be realized, and the position of the photoelectric detector 306 can be adjusted so that the interference excitation light does not enter the photoelectric detector 306, and the single-wavelength detection can be performed.
Further, the photodetector 306 is an APD avalanche photodiode.
Further, the wavelength of the excitation light is 785nm, and the wavelength required for collecting the optical signal is 820nm to 1100nm.
In this embodiment, the focal length of the first plano-concave mirror 303 is 50mm and the focal length of the second plano-concave mirror 305 is 100mm.
Further, the planar reticle reflective grating 304 has a line pair number of 300 lines/mm.
Further, the camera handle 60 may receive 820-1100nm optical signals.
Further, the data collection mode of the data collection module 40 may be single-point collection or scanning collection, the single-point collection mode fixes the angle of the laser galvanometer or the DMD reflector 302, the stepping motor 402 is controlled to collect 830nm spectrum data, the scanning collection mode controls the angle of the laser galvanometer or the DMD reflector 302, and the position of the photoelectric detector 306 is fixed, so that the spectrum of 830-1100nm periodically falls into the photoelectric detector 306, and thus the spectrum data of the target to be measured at 830-1100nm is obtained.
In this embodiment, the light source is 785nm excitation light reflected back from the tissue surface and 820nm to 1100nm fluorescence excited by the excitation light. The composite light passes through the precise optical slit 301 to limit the aperture angle on the y axis, so that the resolution is improved, the light is collimated by the first plano-concave reflecting mirror 303 and then is changed into parallel light, so that the incident angle of the incoming grating is the same, and then different diffraction angles are generated according to the difference of wavelengths by the plane reticle reflecting grating 304, so that the light beams with the same wavelength and the same incident angle are incident on the second plano-concave reflecting mirror 305 at different incident angles, the light beams with the same incident angle are focused on the same position of the photodetector 306, the light beams with different wavelengths and different incident angles are focused on different positions of the space, and the photodetector 306 is an APD avalanche photodiode; the microprocessor can collect the desired light signal by controlling the position of the photodetector 306.
As shown in FIG. 2, there is a trace of 785.+ -.10 nm excitation light and 820nm fluorescence after passing through the spectroscopic system, where the wavelength range of the excitation light is from 775nm to 795nm in the test, considering that the excitation light with a wavelength of 785nm actually has a certain width. In this figure, light of 795nm and 820nm are separated by a distance of 1mm.
The invention also provides an identification method of the parathyroid gland identification device, which comprises the following steps:
s1: the data co-processing module 50 controls the excitation light module 10 to emit excitation light;
s2: the optical signal received by the optical probe 20 is filtered out a specific spectrum signal by the filtering module 30,
s3: the data acquisition module 40 converts the received optical signal into an electrical signal and amplifies the electrical signal to output to the data co-processing module 50,
s4: the data co-processing module 50 AD-converts the received signal, and transmits the converted signal to the main control module 70,
s5: the main control module 70 processes the image signal output by the camera handle 60 and the spectrum signal output by the data co-processing module 50, and sends the processing result to the display module 80 to be presented to the user.
Although the invention has been described hereinabove with reference to embodiments, various modifications thereof may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In particular, the features of the disclosed embodiments may be combined with each other in any manner as long as there is no structural conflict, and the exhaustive description of these combinations is not given in this specification merely for the sake of omitting the descriptions and saving resources. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed, but that the invention will include all embodiments falling within the scope of the appended claims.
Claims (10)
1. The parathyroid recognition device is characterized by comprising an excitation light module (10), an optical probe (20), a light filtering module (30), a data acquisition module (40), a data co-processing module (50), a camera handle (60), a main control module (70) and a display module (80).
2. The parathyroid recognition device according to claim 1, wherein the filtering module (30) comprises a slit (301), a reflecting mirror (302), a first plano-concave reflecting mirror (303), a plane scribing reflection type grating (304), a second plano-concave reflecting mirror (305) and a photodetector (306), the composite light beam is collimated by the first plano-concave reflecting mirror (303) and becomes parallel light after limiting the aperture angle of the incident light by the slit (301), the parallel light is reflected by the reflecting mirror (302) and is incident on the second plano-concave reflecting mirror (305) at different incident angles according to different diffraction angles of wavelengths, and the light beams with different wavelengths are distributed at different spatial positions and enter the photodetector (306).
3. A parathyroid recognition device in accordance with claim 2 wherein the photodetector (306) is an APD avalanche photodiode.
4. A parathyroid recognition device in accordance with claim 3, characterized in that the mirror (302) is a laser galvanometer or a DMD mirror.
5. A parathyroid gland recognition device in accordance with claim 1, characterized in that the data acquisition module (40) comprises an op-amp, a stepper motor (402), the stepper motor (402) being adapted to control the position of the photo detector (306) so as to measure signals of different spatial positions.
6. The parathyroid recognition device of claim 1, wherein the excitation light has a wavelength of 785nm and the light signal is required to be collected has a wavelength of 820nm to 1100nm.
7. A parathyroid recognition device in accordance with claim 1 wherein the first plano-concave mirror (303) has a focal length of 50mm and the second plano-concave mirror (305) has a focal length of 100mm.
8. A fingerprint attendance machine as claimed in claim 1, characterized in that the planar reticle reflection grating (304) has a line pair number of 300 lines/mm.
9. The parathyroid gland recognition device according to claim 1, wherein the data acquisition mode of the data acquisition module (40) can be single-point acquisition or scanning acquisition, the single-point acquisition mode is used for fixing the angle of a laser vibrating mirror or a DMD reflector (302), the stepping motor (402) is controlled to acquire 830nm spectrum data, the scanning acquisition mode is used for controlling the angle of the laser vibrating mirror or the DMD reflector (302), and the position of the photoelectric detector (306) is fixed, so that the spectrum periodicity of 830-1100nm falls into the photoelectric detector (306), and the spectrum data of a target to be detected in 830-1100nm is obtained.
10. A method of identifying a parathyroid gland identification device as claimed in any one of claims 1 to 9 comprising the steps of:
s1: the data co-processing module (50) controls the excitation light module (10) to emit excitation light;
s2: the optical signals received by the optical probe (20) are filtered out specific spectrum signals by a filtering module (30),
s3: the data acquisition module (40) converts the received optical signals into electric signals, amplifies the electric signals and outputs the electric signals to the data co-processing module (50),
s4: the data co-processing module (50) performs AD conversion on the received signal and transmits the converted signal to the main control module (70),
s5: the main control module (70) processes the image signal output by the camera handle (60) and the spectrum signal output by the data co-processing module (50), and sends the processing result to the display module (80) to be presented to the user.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311383640.0A CN117434041A (en) | 2023-10-24 | 2023-10-24 | Parathyroid gland identification device and identification method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311383640.0A CN117434041A (en) | 2023-10-24 | 2023-10-24 | Parathyroid gland identification device and identification method thereof |
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| CN117434041A true CN117434041A (en) | 2024-01-23 |
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| CN202311383640.0A Pending CN117434041A (en) | 2023-10-24 | 2023-10-24 | Parathyroid gland identification device and identification method thereof |
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| US20060228260A1 (en) * | 2003-12-16 | 2006-10-12 | Canon Kabushiki Kaisha | Optical analysis device |
| JP2013148542A (en) * | 2012-01-23 | 2013-08-01 | Hamamatsu Photonics Kk | Fluorescence measurement device |
| US20180306697A1 (en) * | 2015-10-27 | 2018-10-25 | Sony Corporation | Fine particle detection device |
| CN109864715A (en) * | 2019-04-04 | 2019-06-11 | 济南显微智能科技有限公司 | A kind of hand-held human body spontaneous fluorescence detection device |
| CN112190219A (en) * | 2020-11-04 | 2021-01-08 | 王松 | Parathyroid gland cavity mirror system capable of identifying near-infrared light in real time and using method |
| CN113552090A (en) * | 2021-08-12 | 2021-10-26 | 重庆理工大学 | Near-infrared fluorescence spectrometer based on micro scanning grating micro-mirror |
| CN116602623A (en) * | 2023-05-18 | 2023-08-18 | 济南国科医工科技发展有限公司 | Parathyroid optical detection system |
-
2023
- 2023-10-24 CN CN202311383640.0A patent/CN117434041A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060228260A1 (en) * | 2003-12-16 | 2006-10-12 | Canon Kabushiki Kaisha | Optical analysis device |
| JP2013148542A (en) * | 2012-01-23 | 2013-08-01 | Hamamatsu Photonics Kk | Fluorescence measurement device |
| US20180306697A1 (en) * | 2015-10-27 | 2018-10-25 | Sony Corporation | Fine particle detection device |
| CN109864715A (en) * | 2019-04-04 | 2019-06-11 | 济南显微智能科技有限公司 | A kind of hand-held human body spontaneous fluorescence detection device |
| CN112190219A (en) * | 2020-11-04 | 2021-01-08 | 王松 | Parathyroid gland cavity mirror system capable of identifying near-infrared light in real time and using method |
| CN113552090A (en) * | 2021-08-12 | 2021-10-26 | 重庆理工大学 | Near-infrared fluorescence spectrometer based on micro scanning grating micro-mirror |
| CN116602623A (en) * | 2023-05-18 | 2023-08-18 | 济南国科医工科技发展有限公司 | Parathyroid optical detection system |
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