CN117379333A - 二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8护肤功效的应用 - Google Patents
二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8护肤功效的应用 Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
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Abstract
本发明涉及化妆品技术领域,公开了二肽二氨基丁酰苄基酰胺二乙酸盐在协同增效乙酰基六肽‑8中的应用。使用二肽二氨基丁酰苄基酰胺二乙酸盐与乙酰基六肽‑8以本申请所提供范围的质量份之比进行复配,可实现对乙酰基六肽‑8抗衰老功效的协同增效作用,提高皮肤胶原蛋白和弹性蛋白含量。因此,按照本申请所提供的复配比例范围在化妆品和/或护肤品中协同使用二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基四肽‑2,可在较低施用量的情况下发挥明显的皮肤抗衰老作用,提升肌肤紧致度和弹性,减少皱纹的产生。
Description
技术领域
本发明涉及化妆品技术领域,特别涉及二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8护肤功效的应用。
背景技术
生物活性肽类化合物具有高生物活性、易吸收、安全无毒的独特优势,近年来在美容护肤、抗衰老研究课题中的生理作用与生物效应逐渐引发关注。随着医学、营养学、皮肤科学和分子生物学的发展,肽正在被越来越多越深入地研究,科学家发现,肽对皮肤细胞具有各种生物学活性,这些生物学活性物质正被越来越多的揭示出来。生物活性肽为化妆品的研发和应用提供了全新方向和思路。
皮肤老化是人体衰老的一部分,是其外在表现。特征为:松弛下垂、粗糙、皱纹形成、色素失调等。其中,皮肤皱纹形成的原因主要和真皮的进行式萎缩有关。真皮主要由细胞外基质和成纤维细胞组成,在衰老过程中,作为细胞外基质的主要成分的胶原蛋白和弹性纤维变得碎片化且总量减少,引起了皱纹。持续补充或提升胶原蛋白、弹性蛋白的合成,是对抗衰老及皱纹形成的有效方式。
乙酰基六肽-8(Acetyl Hexapeptide-8)是一种神经递质抑制类肽,能抑制神经传导素乙酰胆碱的释放,减少肌肉收缩,从而减少动态纹、表情纹的产生。已有研究表明,乙酰基六肽-8可以增加I型胶原蛋白的合成,提升肌肤紧致度和弹性,减少皱纹的产生。
发明内容
本发明的目的在于提供二肽二氨基丁酰苄基酰胺二乙酸盐在协同增效乙酰基六肽-8护肤功效方面的应用。
本发明的第一方面提供二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8护肤功效的应用,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为(0.2~2):1,所述护肤功效为提高皮肤胶原蛋白和弹性蛋白的功效。
优选地,本发明提供的二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8的应用中,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为0.2:1。
优选地,本发明提供的二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8的应用中,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为1:1。
优选地,本发明提供的二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8的应用中,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为2:1。
本发明的第二方面提供一种具有协同增效作用的多肽组合物,以质量份计,包含二肽二氨基丁酰苄基酰胺二乙酸盐0.2~2份、乙酰基六肽-8 1份。
优选地,本发明提供的具有协同增效作用的多肽组合物中,包含二肽二氨基丁酰苄基酰胺二乙酸盐:0.2份、乙酰基六肽-8:1份。
优选地,本发明提供的具有协同增效作用的多肽组合物中,包含二肽二氨基丁酰苄基酰胺二乙酸盐:1份、乙酰基六肽-8:1份。
优选地,本发明提供的具有协同增效作用的多肽组合物中,包含二肽二氨基丁酰苄基酰胺二乙酸盐:2份、乙酰基六肽-8:1份。
本发明的第三方面提供了本发明第二方面所述的多肽组合物在化妆品和/或护肤品中的应用。
本发明所提供的应用中,所述化妆品和/或护肤品施用于皮肤外表面。
优选地,本发明所提供的应用中,所述化妆品和/或护肤品选自眼霜、面霜、精华、乳液、面膜精华液中的一种或几种。
优选地,本发明所提供的应用中,所述多肽组合物作为添加剂分散于基质原料中,所述基质原料选自油质原料、粉质原料、胶质原料、溶剂原料中的一种或几种。
优选地,本发明所提供的应用中,所述化妆品和/或护肤品还包括:表面活性剂、香精与香料、色素、保湿剂、防腐剂、抗氧剂、紫外线吸收剂、螯合剂、收敛剂、助渗剂、营养性添加剂中的一种或几种。
相对于现有技术而言,申请人提出,使用二肽二氨基丁酰苄基酰胺二乙酸盐与乙酰基六肽-8以本申请所提供的质量份比值范围进行复配,可实现对乙酰基六肽-8抗衰老功效的显著的协同增效作用,显著提高皮肤胶原蛋白和弹性蛋白。在本申请的申请日前,二肽二氨基丁酰苄基酰胺二乙酸盐已被公开报道的功效包括减少肌肉收缩和改善鱼尾纹等表情纹;没有任何现有技术文献提到或启示,二肽二氨基丁酰苄基酰胺二乙酸盐具有促进皮肤胶原蛋白和弹性蛋白的作用。按照本申请所提供的复配比例范围在化妆品和/或护肤品中协同使用二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基四肽-2,可在较低施用量的情况下发挥明显的皮肤抗衰老作用,提升肌肤紧致度和弹性,减少皱纹的产生。
附图说明
图1为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8协同增效试验的流程示意图;
图2为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以20μg/ml单独给药或质量比为1:1联合给药,对HFF-1细胞Col-I mRNA表达的影响效果对比图;
图3为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以10μg/ml单独给药或质量比为1:5联合给药,对HFF-1细胞Elastin mRNA表达的影响效果对比图;
图4为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以10μg/ml单独给药或质量比为2:1联合给药,对HFF-1细胞Elastin mRNA表达的影响效果对比图;
图5为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以20μg/ml单独给药或质量比为1:5联合给药,对HFF-1细胞Elastin mRNA表达的影响效果对比图。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的各实施方式进行详细的阐述。然而,本领域的普通技术人员可以理解,在本发明各实施方式中,为了使读者更好地理解本申请而提出了许多技术细节。但是,即使没有这些技术细节和基于以下各实施方式的种种变化和修改,也可以实现本申请所要求保护的技术方案。
本发明的部分实施方式提供二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8护肤功效的应用,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为(0.5~2):1;所述护肤功效为提高皮肤胶原蛋白和弹性蛋白的功效。
在本发明部分实施方式提供中,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为(1~2):1。
本发明的部分实施方式提供一种具有协同增效作用的多肽组合物,以质量份计,包含:二肽二氨基丁酰苄基酰胺二乙酸盐:0.5~2份;乙酰基六肽-8:1份。
在本发明部分实施方式提供提供的具有协同增效作用的多肽组合物中,以质量份计,包含:二肽二氨基丁酰苄基酰胺二乙酸盐:1~2份;乙酰基六肽-8:1份。
本发明的部分实施方式还提供上述多肽组合物在化妆品和/或护肤品中的应用。
本发明的实施方式所提供的多肽组合物可应用于化妆品和/或护肤品中,所述化妆品和/或护肤品施用于皮肤外表面。
在本发明部分实施方式中,应用所述多肽组合物的化妆品和/或护肤品选自眼霜、面霜、精华、乳液、面膜精华液中的一种或几种。
本发明部分实施方式中,所述多肽组合物作为添加剂分散于基质原料中,所述基质原料选自油质原料、粉质原料、胶质原料、溶剂原料中的一种或几种。
其中,所述油质原料可以是下述基质原料中的任意一种或几种组合:大豆油、橄榄油、杏仁油、蓖麻油、花生油、棉籽油、茶籽油、霍霍巴油、鳄梨油、椰子油、棕榈油、可可脂、米糠油、月见草油、小麦胚芽油、玉米胚芽油、棕榈蜡、木蜡、水貂油、海龟油、蛇油、蛋黄油、牛脂、马脂、猪脂、鹿脂、卵磷脂、羊毛脂、蜂蜡、鲸蜡、虫胶蜡、石蜡、凡士林、微晶蜡、地蜡、角鲨烷、羊毛脂蜡、羊毛脂醇、羊毛脂醇酯化物、乙酰化羊毛脂、乙酰化羊毛脂醇、羊毛脂酸、羊毛脂酸酯化物、聚氧乙烯羊毛脂、聚氧乙烯羊毛醇醚、聚氧丙烯羊毛醇醚、氢化羊毛脂、烷氧基化氢化羊毛脂、硅油(如:二甲基硅油、八甲基硅油、甲基苯基聚硅氧烷)、聚硅氧烷-聚氧烷基嵌段共聚物、甲基含氢硅油、Cn脂肪酸及其酯、Cn脂肪醇及其酯;其中,n≥10,并优选为10-24,更优选为12-20,如14、16、17、18。
所述Cn脂肪酸如:月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、油酸、亚油酸、芥酸、癸酸。
所述Cn脂肪醇如:月桂醇、鲸蜡醇、硬脂醇、异硬脂醇、油醇、椰油醇。
所述Cn脂肪酸酯、Cn脂肪醇酯如:肉豆蔻酸异丙酯、肉豆蔻酸肉豆蔻酯、十四醇乳酸酯、十六醇乳酸酯、棕榈酸异丙酯、棕榈树异辛酯、硬脂酸丁酯、硬脂酸异辛酯、硬脂酸单甘油脂、硬脂酸聚乙二醇酯、油酸癸酯、辛酸甘油酯、癸酸甘油酯、甘油三油酸酯。
所述粉质原料可以是下述基质原料中的任意一种或几种组合:云母、碳酸镁、钛白粉、锌白粉、氢氧化钙、碳酸钙、高岭土、硬脂酸钙、硬脂酸锌、硬脂酸镁、滑石粉、二氧化硅、氢氧化铝、焦磷酸钙、碳酸氢钙、膨润土。
其中,胶质原料是在水中膨胀成胶体,可使固体粉质原料黏合成型,对乳状液或悬状剂起到乳化作用,此外还有增稠或凝胶化作用,常用的胶质原料包括有植物凝胶、动物明胶等。
其中,所述溶剂原料可以是下述基质原料中的任意一种或几种组合:水、乙醇、丙醇、异丙醇、异丁醇、乙二醇、1,2-丙二醇、环己烷、二氯二氟甲烷、四氟二氯乙烷、乙二醇单乙醚、二甘醇单乙醚、丙酮、甲基异丁基甲酮、醋酸乙酯、醋酸丁酯、乙酸戊酯、邻苯二甲酸二丁酯。
在本发明部分实施方式中,应用所述多肽组合物的化妆品和/或护肤品还包括:表面活性剂、香精与香料、色素、保湿剂、防腐剂、抗氧剂、紫外线吸收剂、螯合剂、收敛剂、助渗剂、营养性添加剂中的一种或几种。
其中,所述表面活性剂可以是:1)阴离子表面活性剂,如:C12-14脂肪醇硫酸铵、C12-14脂肪醇聚氧乙烯醚羧酸盐、十二烷基硫酸二乙醇胺盐、C12-14脂肪醇聚氧乙烯醚硫酸铵、十二烷基硫酸三乙醇胺、醇醚邻苯二甲酸单酯钠盐、酰化肽、月桂酸单乙醇酰胺硫酸钠、正辛醇聚氧丙烯醚琥珀酸单酯磺酸盐、十六醇琥珀酸单酯磺酸盐、磺基琥珀酸单酯二钠盐、琥珀酸单十八酯二钠盐、醇醚磺基琥珀酸单酯二钠盐、脂肪醇聚氧乙烯醚(钠)磺基琥珀酸单酯铵盐、油酰胺磺基琥珀酸单酯二钠盐、N-酰基谷氨酸钾盐、吡咯烷酮羧酸钠、聚丙烯酸钠、脂肪醇聚氧乙烯醚磷酸酯、脂肪醇聚氧乙烯醚磷酸单酯及其盐、脂肪醇聚氧乙烯醚磷酸单酯乙醇胺盐、烷基酚聚氧乙烯醚磷酸单酯及其盐、壬基酚醚磷酸单酯乙醇胺盐、烷基磷酸酯盐、邻苯二甲酸单月桂醇酯盐、十一碳烯酸锌、阴离子型氨基酸表面活性剂、N-C12-18酰基谷氨酸钠、N-月桂酰L-丙氨酸钠、N-硬脂酰基谷氨酸单钠盐、N-椰子酰基谷氨酸单钠盐、N-混合脂肪酰基谷氨酸单钠盐、长直链烷基芳醚磺酸钠TH;2)非离子表面活性剂,如:油醇聚氧乙烯醚(如乳化剂VO系列)、烷基酚聚氧乙烯醚(如乳化剂OPE系列)、硬脂酸聚氧乙烯酯、乙二醇单硬脂酸酯、二硬脂酸乙二醇酯、聚乙二醇单硬脂酸酯、聚乙二醇双硬脂酸酯、聚乙二醇双月桂酸酯、双硬脂酸甘油酯、三硬脂酸甘油酯、蔗糖硬脂酸酯、聚氧乙烯甘油醚单硬脂酸酯、N-月桂酰基谷氨酸双烷醇酯、苯甲酸脂肪醇酯、山梨醇单脂肪酸酯(司盘,Span,如司盘-20、司盘60、司盘65、司盘-80、司盘-83、司盘-85)、聚氧乙烯醚山梨醇单脂肪酸酯(吐温,Tween,如吐温-20、吐温-40、吐温-60、吐温-61、吐温-80)、二乙醇胺、三乙醇胺、脂肪酸单乙醇酰胺(如椰子油酸单乙醇酰胺、月桂酸单乙醇酰胺、棕榈酸单乙醇酰胺)、椰子油酸二乙醇酰胺、月桂酸二乙醇酰胺、甲基葡萄糖苷硬脂酸酯、聚氧乙烯甲基葡萄糖苷硬脂酸酯、乙二醇葡萄糖苷硬脂酸酯、丙二醇基葡萄糖苷硬脂酸酯、C8-16烷基葡萄糖苷、甘油葡萄糖苷硬脂酸酯、琥珀酸月桂醇醚单酯、月桂醇甘油酯聚氧乙烯醚、硬脂酸甘露醇酐酯、聚氧乙烯貂油、貂油酸甲酯、貂油酸异丙酯;3)阳离子表面活性剂,如氯化C12-18烷基三烷基铵(如氯化十六烷基二甲基烷基铵、氯化十八烷基三甲基铵、氯化十六烷基三甲基铵)、氯化油酰胺丙基二羟丙基二甲基铵、氯化二羟丙基二甲基十二烷基铵、氯化二甲基二烯丙基铵/丙烯酰胺共聚物、氯化油酰胺丙基-2,3-二羟丙基二甲基铵、乙基硫酸油酰胺丙基二甲基乙基铵、氯化双C12-18基二甲基铵、聚季铵-11调理剂、M-505聚季铵-7调理剂、貂油酰胺丙基胺-壳聚糖、貂油酰胺丙基胺-水解蛋白、阳离子蛋白肽、瓜尔胶-羟丙基三甲基氯化铵盐、聚纤维素醚季铵盐、单油酸三乙醇胺酯、DNP系列;4)两性离子表面活性剂,如C12-18烷基二羟乙基甜菜碱、N-C12-18烷基-N-(2-羟乙基)-N-(2-甲酰胺基乙基)铵乙酸盐、C12-18烷氧基羟丙基甜菜碱、氧化椰油酰胺基丙基胺、椰油羟乙基磺酸钠、氧化十八烷基二甲基胺、椰油酰二乙醇胺氧化胺、N-烷基-β-氨基丙酰二乙醇胺、氧化月桂酰基丙胺、N-C12-18酰基谷氨酸、羟乙基癸酸咪唑啉甜菜碱、羟乙基肉豆蔻酸咪唑啉甜菜碱、羟乙基棕榈酸咪唑啉甜菜碱。
其中,所述香精与香料可以是选自:1)天然香料,如苦艾油、桉叶油、八角茴香油、白柠檬油、白丁香浸膏、丁香油、白兰花油、白兰花浸膏、白兰叶油、柏木油、薄荷油、苍术硬脂、草木犀浸膏、橙叶油、丁香罗勒油、大花茉莉浸膏、冬青油、当归油、当归浸膏、地衣酸、地檀香油、玳玳花油、玳玳叶油、风信子浸膏、枫香浸膏、芳樟油、黄樟油、甘松油、桂花浸膏、红橘油、胡萝卜籽油、海狸香、黄葵油、黄兰油、藿香油、黄蒿油、九里香浸膏、金合欢浸膏、姜油、橘子油、椒样薄荷油、菊花浸膏、枯茗油、龙涎香、留兰香油、灵猫香、腊梅油、铃兰浸膏、木香根油、米兰花油、玫瑰香叶油、玫瑰油、茉莉浸膏、牡蛎油、墨红浸膏、墨红油、柠檬桉叶油、柠檬油、七里香浸膏、楠叶油、芹菜籽油、肉豆蔻油、肉桂油、山苍子油、水貂香膏酊、水仙浸膏、松针油、树苔浸膏、素馨浸膏、麝香、麝鼠香膏、甜橙油、檀香油、晚香玉油、晚香玉浸膏、万寿菊精油、小茴香油、血桧木油、香茅油、香叶油、康乃馨油、紫苏油、香紫苏油、香附油、香柠檬薄荷油、岩兰草油、香薷油、香薷草浸膏、悬钩子蔷薇花油、悬钩子蔷薇花浸膏、薰衣草油、月桂叶油、依兰依兰油、芫荽籽油、鱼香草油、岩蔷薇浸膏、岩桂油、柚皮油、鸢尾油、烟草花油、香橼叶油、栀子花浸膏、紫穗槐油、紫罗兰叶浸膏、愈创木酚、4-甲基愈创木酚、4-乙基愈创木酚、天然香兰素、樟脑;2)合成香精,如柠檬烯、长叶烯、乙位石竹烯、异长叶烯、异长叶烯酮、异长叶烷酮、溴代苏合香烯、二苯甲烷、二苯醚、间甲基二苯醚、丁香酚、异丁香酚、乙位萘甲醚、乙位萘乙醚、对甲基茴香醚、异丁香酚苄醚、玫瑰醚、檀香醚、水仙醚(或茉莉醚)、降龙涎香醚、甲基柏木醚、环氧柏木烷、埃林塔尔、埃林塔尔N、3-己烯醇、癸醇、月桂醇、苯甲醇、苯乙醇、对甲氧基苄醇、肉桂醇、二甲基苄基甲醇、香叶醇、橙花醇、芳樟醇、玫瑰醇、松油醇、香茅醇、消旋薄荷脑、薄荷脑、冰片、柏木醇、柏木烷酮、甲基柏木酮、3,4-二氧亚甲基苯甲醇、α-甲基-3,4-二氢亚甲基苯丙醛、2-叔丁基-4-甲基环己醇、香紫苏醇、檀香醇、3-甲基-5-(2’,2’,3’-三甲基环戊烯-1’-基)戊-2-醇、苯甲醛、苯乙酮、苯乙酸、对甲基苯乙酮二苯甲酮、月桂醛、肉桂醛、肉桂酸、α-戊基-β-苯基丙烯醛、α-苯基丙醛、铃兰醛、新铃兰醛、兔耳草醛、3,4-二氧亚甲基苯甲醛、3,7-二甲基-6-辛烯醛、3,7-二甲基-7-羟基辛醛、柠檬醛、乙位环高柠檬醛、艾薇醛、柑青醛、4-羟基-3-甲氧基苯甲醛、α-二氢突厥酮、β-突厥烯酮、紫罗兰酮、6-甲基紫罗兰酮、橙花酮、香芹酮、胡椒基丙酮、覆盆子酮、药草酮、顺式茉莉酮、庚醛乙二醇缩醛、苯乙醛二甲缩醛、辛醛二甲缩醛、α-戊基桂醛二甲缩醛、柠檬醛二甲缩醛、柠檬醛二乙缩醛、茴香醛二甲缩醛、蘑菇醛、叶青素、风信子素、苹果酯、吉普缩酮、甲酸香叶酯、甲酸香茅酯、阿弗曼酯、乙酸叶醇酯、乙酸苄酯、乙酸苯乙酯、乙酸肉桂酯、乙酸松油酯、乙酸龙脑酯、乙酸芳樟酯、乙酸香叶酯、乙酸对叔丁基环己酯、乙酸邻叔丁基环己酯、乙酸香根酯、乙酸琥珀酯、乙酸阿弗曼酯、乙酸十氢萘酯、乙酸柏木酯、丙酸香叶酯、乙酸三氯甲基苯甲酯、丁酸苄酯、丁酸叶醇酯、丁酸香叶酯、2-甲基戊酸苯乙酯、异丁酸对甲酚酯、2-壬烯酸甲酯、苯甲酸乙酯、苯甲酸甲酯、苯甲酸叶醇酯、苯甲酸苄酯、苯乙酸乙酯、苯乙酸对甲酚酯、肉桂酸乙酯、水杨酸丁酯、水杨酸异丁酯、水杨酸异戊酯、水杨酸叶醇酯、水杨酸己酯、水杨酸苄酯、水杨酸苯乙酯、水杨酸环己酯、茉莉素、茉莉酯、2-戊基环戊酮醋酸甲酯、橙花素、γ-壬内酯、γ-十一内酯、香豆素、吲哚、3-甲基吲哚、3,7-二甲基-2,6-辛二烯腈、对甲氧基苯甲腈、二甲苯麝香、酮麝香、2,6-二硝基-3-甲氧基-4-叔丁基甲苯、1,1-二甲基-4-乙酰基-6-叔丁基茚满、六甲基三环异色满麝香、1,1,2,3,3,6-六甲基-5-乙酰基茚满、麝香-T、麝香-M、麝香-L、麝香-F、11-氧杂环十六内酯、吐纳麝香;3)香精,玫瑰香精、茉莉香精、檀香香精、白兰香精。
其中,所述色素可以是选自如下组分中的一种或几种:二氧化锆、醋酸铅、硝酸银、叶绿素、叶绿素铜、亚铁氰化铁、鸟嘌呤、坚牢红、食品红I、还原红I、胭脂红、食用杨梅红、食用樱桃红、食品红17、苋菜红、坚牢绿、食品黄3、食用柠檬黄、食用苏丹黄、食用靛蓝、食品蓝2、荧光桃红、β-胡萝卜素、指甲花、栀子红色素、栀子绿色素、栀子蓝色素、栀子黄色素、钛云母珠光颜料、氧化铁红、氧化铁黄、氧化铁黑、氧化铬绿、氧氯化铋、碱性桃红、银朱R、喹啉黄、紫草宁、紫胶红色素、群青、酸性红87、酸性绿25、酸性荧光黄、酸性橙7、金光红53、立索尔宝红BK、立索尔宝红2R、永固橙。
其中,所述防腐剂可以是选自如下组分中的一种或几种组合:山梨酸及其盐、丙酸盐、对羟基苯甲酸酯、苯甲醇、苯甲酸及其盐、5-氯-2-甲基-4-异噻唑啉-3-酮、-2-甲基-4-异噻唑啉-3-酮、卡松、咪唑烷基脲、脱氢醋酸及其盐、亚硫酸钠、亚硫酸氢钠、焦亚硫酸钠、2,2-溴-2-硝基-1,3-丙二醇(布罗波尔)、异抗坏血酸及其盐、曲酸及其酯、壬二酸、松萝酸、间苯二酚。
其中,所述抗氧剂可以是选自如下组分中的一种或几种组合:SOD、丁基羟基茴香醚、没食子酸酯、抗坏血酸及其盐、异抗坏血酸及其盐、谷甾醇、芦丁、生育酚。
其中,所述保湿剂可以是选自如下组分中的一种或几种组合:1,2-丁二醇、山梨醇、木糖醇、甘油、乳酸盐、聚乙二醇、DL-吡咯烷酮羧酸盐、D-葡萄糖、曲酸及其酯、尿酸、乳清酸、果胶酸、昆布氨酸、胶原蛋白、海藻糖、12、羟基硬脂酸胆甾醇酯。
其中,所述紫外线吸收剂可以是选自如下组分中的一种或几种组合:吡哆醇盐酸盐、曲酸及其酯、芦丁、芦荟苷、咖啡氨酸、橙皮素、2-乙基己基水杨酸酯、2-乙基己基对二甲基氨基苯酸酯、2-乙基己基对甲氧基肉桂酸酯、水杨酸苯酯、基邻氨基苯甲酸酯、2-羟基-4-甲氧基二苯甲酮、2-羟基-4-甲氧基二苯甲酮-5-磺酸、2-羟基-4-辛氧基二苯甲酮。
其中,所述螯合剂可以是选自如下组分中的一种或几种组合:EDTA二钠盐、双吡啶硫酮锌、硫代硫酸钠。
其中,所述收敛剂可以是选自如下组分中的一种或几种组合:苯酚对磺酸锌、羟基氯化铝、硫酸铝、硫酸铝钾、硫酸锌、氯化铝、氯化锌、卡拉明。
其中,所述助渗剂可以是选自如下组分中的一种或几种组合:二甲基亚砜、1-正十二烷基氮杂环庚-2-酮、2-氨基乙醇。
其中,所述pH值调节剂可以是选自如下组分中的一种或几种组合:酒石酸、乳酸、硼酸、琥珀酸。
其中,所述营养性添加剂可以是选自如下组分中的一种或几种组合:甲壳素、壳聚糖、丝肽、丝素、卵磷脂、表皮细胞生长因子、海藻糖、乳糖、珍珠粉、胶原蛋白、胶原水解物、透明质酸及其盐、蛋膜素、植物甾醇、氯化溶菌酶、硫酸软骨素钠、蜂乳、蜂胶、蜂蜜、甘草酸、甘草次酸、γ-亚麻酸、曲酸及其酯、赤霉酸、甘氨酸、L-天冬氨酸及其盐、L-胱氨酸及其盐、DL-丙氨酸、L-丝氨酸、DL-丝氨酸、L-蛋氨酸、DL-蛋氨酸、L赖氨酸盐酸盐、L苏氨酸、肌醇、麦芽醇、泛酸盐、D-泛醇、视黄醇醋酸酯、尿囊素、吡哆醇盐酸盐、可的松、烟酰胺、维生素、雌激素、苏木素、尿酸、乳清酸、芦荟苷、壬二酸、松香酸、松萝酸、昆布氨酸、胸腺素、茜草素、柠檬烯、黄芩黄素、脱氧胆酸、愈疮木萸、橙皮素、鞣酸、二硫化硒、茶皂苷、柠檬酸三乙酯、丁基羟基甲苯、植酸、聚氯化二甲基二烯丙基铵。
实验例
实验例中用到的仪器、试剂盒、细胞和试剂均可通过公开的商业渠道购买,为本领域常用的仪器、试剂盒、细胞和试剂,仪器和试剂盒的使用操作步骤按照其说明书的指导进行。
一、主要仪器与试剂
表1试验所用主要仪器
表2试验所用主要试剂
表3试验所用引物序列
二、试验系统
1、试验原料
原料1:乙酰基六肽-8,商品名:Amplified peptide。
原料2:二肽二氨基丁酰苄基酰胺二乙酸盐,商品名:-AKE。
2、试验细胞
细胞品种:HFF-1人皮肤成纤维样细胞。
来源:中国科学院典型培养物保藏委员会上海细胞库。
细胞类型:贴壁细胞。
培养条件:5%CO2,37℃恒温培养箱。
培养基:89%DMEM+10%FBS+1%双抗。
3、试验方法
3.1试剂的配制
受试物和对照品用DMSO或者ddH2O配制成母液,再用无血清培养基或者PBS稀释至合适浓度。
Col-I抗体用抗体稀释液进行1:100稀释,Elastin抗体用抗体稀释液进行1:50稀释,注意避光,现配现用。
3.2试验分组
二肽二氨基丁酰苄基酰胺二乙酸盐与乙酰基六肽-8协同增效试验的分组与给药剂量如表4所示:
表4二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8协同增效试验分组与给药
(联合给药中,例如,二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以总10μg/ml、质量比为1:1给药的具体方案为:二肽二氨基丁酰苄基酰胺二乙酸盐5μg/ml和乙酰基六肽-8 5μg/ml复配联合给药。)
3.3操作步骤
3.3.1 qPCR法检测
取指数生长期的细胞制成单细胞悬液,HFF-1以1×105cells/mL的密度接种于6孔板中,用含10%胎牛血清的培养基37℃培养24h使细胞贴壁,培养终体积为2mL。而后吸弃上清,加入无血清培养基或新鲜制备的含不同浓度药物的无血清培养基孵育,培养终体积为2mL。48h后,按RNA提取标准操作流程提取各孔RNA,qPCR法检测Col-I mRNA、Elastin mRNA的表达。
图1为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8协同增效试验的流程示意图。
4、实验结果
每个实验组进行3次平行实验,实验结果的录入采用Excel录入和Prism(Version7)软件包统计处理,以均数±标准误表示。各数据做单因素方差分析,认为p<0.05有统计学差异。
图2为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以20μg/ml单独给药或质量比为1:1联合给药,对HFF-1细胞Col-I mRNA表达的影响效果对比图;
图3为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以10μg/ml单独给药或质量比为1:5联合给药,对HFF-1细胞Elastin mRNA表达的影响效果对比图;
图4为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以10μg/ml单独给药或质量比为2:1联合给药,对HFF-1细胞Elastin mRNA表达的影响效果对比图;
图5为二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以20μg/ml单独给药或质量比为1:5联合给药,对HFF-1细胞Elastin mRNA表达的影响效果对比图。
注:(1)图2~5中,采用#、##、###代表与乙酰基六肽-8单独给药相比,联合给药的功效具有显著性提高,#:p<0.05;##:p<0.01;###:p<0.001。
(2)图2~5中,采用*、**、***代表与二肽二氨基丁酰苄基酰胺二乙酸盐单独给药相比,联合给药的功效具有显著性提高,*:p<0.05;**:p<0.01;***:p<0.001。
试验结果表明:
与乙酰基六肽-8单独给药相比,二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以质量比为(0.2~2):1联合给药,能显著促进HFF-1细胞Col-I mRNA、Elastin mRNA的表达。
Col-I(I型胶原蛋白)是占人体胶原蛋白总量最多的一类胶原蛋白,是脊椎动物中最丰富的蛋白质,对肌肤的紧致和弹性起着关键作用。Elastin是弹性蛋白,和胶原蛋白一样是皮肤中最重要的结构蛋白,其表达量的增加能起到显著的抗衰皮肤老作用。本发明通过对比例和实验例清楚和明确地证实,在化妆品和/或护肤品中协同使用二肽二氨基丁酰苄基酰胺二乙酸盐和乙酰基六肽-8以质量比为(0.2~2):1复配,即可在较低施用量的情况下发挥更为明显的皮肤抗衰老功效,在促进HFF-1细胞Col-I mRNA和Elastin mRNA的表达方面实现协同增效,显著提高皮肤胶原蛋白和弹性蛋白,提升肌肤紧致度和弹性,减少皱纹的产生。
本领域的普通技术人员可以理解,上述各实施方式是实现本发明的具体实施例,而在实际应用中,可以在形式上和细节上对其作各种改变,而不偏离本发明的精神和范围。
Claims (10)
1.二肽二氨基丁酰苄基酰胺二乙酸盐协同增效乙酰基六肽-8护肤功效的应用,其特征在于,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为(0.2~2):1;所述护肤功效为促进皮肤胶原蛋白和弹性蛋白的功效。
2.根据权利要求1所述的应用,其特征在于,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为0.2:1。
3.根据权利要求1所述的应用,其特征在于,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为1:1。
4.根据权利要求1所述的应用,其特征在于,所述二肽二氨基丁酰苄基酰胺二乙酸盐和所述乙酰基六肽-8的质量份之比为2:1。
5.一种具有协同增效作用的多肽组合物,其特征在于,以质量份计,包含:二肽二氨基丁酰苄基酰胺二乙酸盐:0.2~2份、乙酰基六肽-8:1份;
优选地,二肽二氨基丁酰苄基酰胺二乙酸盐:0.2份、乙酰基六肽-8:1份;优选地,二肽二氨基丁酰苄基酰胺二乙酸盐:1份、乙酰基六肽-8:1份;优选地,二肽二氨基丁酰苄基酰胺二乙酸盐:2份、乙酰基六肽-8:1份。
6.权利要求5所述的具有协同增效作用的多肽组合物在化妆品和/或护肤品中的应用。
7.根据权利要求6所述的应用,其特征在于,所述化妆品和/或护肤品施用于皮肤外表面。
8.根据权利要求6所述的应用,其特征在于,所述化妆品和/或护肤品选自眼霜、面霜、精华、乳液、面膜精华液中的一种或几种。
9.根据权利要求6所述的应用,其特征在于,所述多肽组合物作为添加剂分散于基质原料中,所述基质原料选自油质原料、粉质原料、胶质原料、溶剂原料中的一种或几种。
10.根据权利要求6所述的应用,其特征在于,所述化妆品和/或护肤品还包括:表面活性剂、香精与香料、色素、保湿剂、防腐剂、抗氧剂、紫外线吸收剂、螯合剂、收敛剂、助渗剂、营养性添加剂中的一种或几种。
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