CN117342931A - Preparation method of 5-alkyl resorcinol compound - Google Patents
Preparation method of 5-alkyl resorcinol compound Download PDFInfo
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- CN117342931A CN117342931A CN202210734889.0A CN202210734889A CN117342931A CN 117342931 A CN117342931 A CN 117342931A CN 202210734889 A CN202210734889 A CN 202210734889A CN 117342931 A CN117342931 A CN 117342931A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- GHMLBKRAJCXXBS-UHFFFAOYSA-N Resorcinol Natural products OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 title claims abstract description 10
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 14
- 239000003054 catalyst Substances 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims abstract description 9
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims abstract description 7
- 230000009471 action Effects 0.000 claims abstract description 5
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 30
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 14
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 9
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 8
- -1 p-methoxybenzyl Chemical group 0.000 claims description 8
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 8
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 7
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 7
- 229910052794 bromium Inorganic materials 0.000 claims description 7
- 229910052736 halogen Inorganic materials 0.000 claims description 7
- 150000002367 halogens Chemical class 0.000 claims description 7
- LCPVQAHEFVXVKT-UHFFFAOYSA-N 2-(2,4-difluorophenoxy)pyridin-3-amine Chemical compound NC1=CC=CN=C1OC1=CC=C(F)C=C1F LCPVQAHEFVXVKT-UHFFFAOYSA-N 0.000 claims description 6
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzonitrile Chemical compound N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000001624 naphthyl group Chemical group 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 6
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Substances [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 4
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 4
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 claims description 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims description 4
- 125000001424 substituent group Chemical group 0.000 claims description 4
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 claims description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 2
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 claims description 2
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N hexane Substances CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 235000009518 sodium iodide Nutrition 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008096 xylene Substances 0.000 claims description 2
- IRMPFYJSHJGOPE-UHFFFAOYSA-N olivetol Chemical compound CCCCCC1=CC(O)=CC(O)=C1 IRMPFYJSHJGOPE-UHFFFAOYSA-N 0.000 description 11
- 230000002829 reductive effect Effects 0.000 description 11
- 238000004440 column chromatography Methods 0.000 description 10
- 238000001914 filtration Methods 0.000 description 10
- RQGAOBDPFOADCM-UHFFFAOYSA-N methyl 2,4-dihydroxy-6-pentylbenzoate Chemical compound CCCCCC1=CC(O)=CC(O)=C1C(=O)OC RQGAOBDPFOADCM-UHFFFAOYSA-N 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- NCCWCZLEACWJIN-UHFFFAOYSA-N orsellinic acid methyl ester Chemical compound COC(=O)C1=C(C)C=C(O)C=C1O NCCWCZLEACWJIN-UHFFFAOYSA-N 0.000 description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 5
- 238000009776 industrial production Methods 0.000 description 5
- 229910052740 iodine Inorganic materials 0.000 description 5
- 239000011630 iodine Substances 0.000 description 5
- FETWVVHGLAIOOR-UHFFFAOYSA-N methyl 2-hydroxy-4-oxo-6-pentylcyclohex-2-ene-1-carboxylate Chemical compound CCCCCC1CC(=O)C=C(O)C1C(=O)OC FETWVVHGLAIOOR-UHFFFAOYSA-N 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- ALCUWNWVZNZFHQ-UHFFFAOYSA-N ethyl 2,4-dihydroxy-6-pentylbenzoate Chemical compound CCCCCC1=CC(O)=CC(O)=C1C(=O)OCC ALCUWNWVZNZFHQ-UHFFFAOYSA-N 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- CBHXMWWKQZREOA-UHFFFAOYSA-N 3-hydroxy-5-pentylcyclohex-2-en-1-one Chemical compound CCCCCC1CC(O)=CC(=O)C1 CBHXMWWKQZREOA-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 238000006845 Michael addition reaction Methods 0.000 description 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 2
- 238000005899 aromatization reaction Methods 0.000 description 2
- ILAHWRKJUDSMFH-UHFFFAOYSA-N boron tribromide Chemical compound BrB(Br)Br ILAHWRKJUDSMFH-UHFFFAOYSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 238000006114 decarboxylation reaction Methods 0.000 description 2
- 238000005984 hydrogenation reaction Methods 0.000 description 2
- SEBIQMPNDQLYOX-UHFFFAOYSA-N methyl 2-hydroxy-6-methyl-4-oxocyclohex-2-ene-1-carboxylate Chemical compound COC(=O)C1C(C)CC(=O)C=C1O SEBIQMPNDQLYOX-UHFFFAOYSA-N 0.000 description 2
- OIPPWFOQEKKFEE-UHFFFAOYSA-N orcinol Chemical compound CC1=CC(O)=CC(O)=C1 OIPPWFOQEKKFEE-UHFFFAOYSA-N 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000001308 synthesis method Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- HAQLHRYUDBKTJG-UHFFFAOYSA-N 3,5-dihydroxybenzaldehyde Chemical compound OC1=CC(O)=CC(C=O)=C1 HAQLHRYUDBKTJG-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 229910021589 Copper(I) bromide Inorganic materials 0.000 description 1
- 240000004181 Eucalyptus cladocalyx Species 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- PZHNKNRPGLTZPO-VZRGJMDUSA-N Grifolin Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CC1=C(O)C=C(C)C=C1O PZHNKNRPGLTZPO-VZRGJMDUSA-N 0.000 description 1
- PZHNKNRPGLTZPO-UHFFFAOYSA-N Grifolin Natural products CC(C)=CCCC(C)=CCCC(C)=CCC1=C(O)C=C(C)C=C1O PZHNKNRPGLTZPO-UHFFFAOYSA-N 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- CZMRCDWAGMRECN-UHFFFAOYSA-N Rohrzucker Natural products OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O CZMRCDWAGMRECN-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010064390 Tumour invasion Diseases 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 150000001323 aldoses Chemical class 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005893 bromination reaction Methods 0.000 description 1
- 125000005997 bromomethyl group Chemical group 0.000 description 1
- QHMBSVQNZZTUGM-ZWKOTPCHSA-N cannabidiol Chemical class OC1=CC(CCCCC)=CC(O)=C1[C@H]1[C@H](C(C)=C)CCC(C)=C1 QHMBSVQNZZTUGM-ZWKOTPCHSA-N 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- NKNDPYCGAZPOFS-UHFFFAOYSA-M copper(i) bromide Chemical compound Br[Cu] NKNDPYCGAZPOFS-UHFFFAOYSA-M 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- JHIVVAPYMSGYDF-PTQBSOBMSA-N cyclohexanone Chemical class O=[13C]1CCCCC1 JHIVVAPYMSGYDF-PTQBSOBMSA-N 0.000 description 1
- 238000006264 debenzylation reaction Methods 0.000 description 1
- 238000007256 debromination reaction Methods 0.000 description 1
- 230000017858 demethylation Effects 0.000 description 1
- 238000010520 demethylation reaction Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000005580 one pot reaction Methods 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 150000002972 pentoses Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/06—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation
- C07C37/07—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by conversion of non-aromatic six-membered rings or of such rings formed in situ into aromatic six-membered rings, e.g. by dehydrogenation with simultaneous reduction of C=O group in that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
Abstract
The invention relates to a preparation method of a 5-alkyl resorcinol compound. Specifically, the method comprises the steps of: under the action of a catalyst and persulfate, the compound shown in the formula (2) is subjected to dehydroaromatization reaction to obtain the 5-alkyl resorcinol compound shown in the formula (1).
Description
Technical Field
The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of a 5-alkyl resorcinol compound.
Background
The 5-alkyl resorcinol compounds are medical intermediates with higher activity and wide application. The 5-methyl resorcinol can be used for synthesizing the Blastamycin and the grifolin with anti-tumor invasion activity, and can also be used for detecting antimony, chromium, nitrate and nitrite, pentose, lignin, sugar gum, aldose, beet sugar, sucrose, amylase and the like; the 5-amyl resorcinol can be used for synthesizing cannabidiol compounds. The structural formula of the 5-amyl resorcinol is shown in the following formula (3):
the current routes for synthesizing the compounds of formula (3) are mainly as follows:
route one
The aldehyde reagent sequentially undergoes a Witting reaction, a Michael addition reaction and a Crisen condensation reaction to obtain a sodium salt intermediate, and reacts with cuprous bromide to obtain a brominated product. The 5-amylresorcinol is then obtained by debromination and decarboxylation in a final yield of about 50% (J.org.chem.1972, 37,18). The routing reagents used in this route are expensive, making this route costly. In addition, the bromination reaction in this route produces polybrominated substituents, which makes it difficult to obtain high purity products that meet market demands.
Route two
The alpha, beta-unsaturated ketone reagent is subjected to Michael addition and Criessen condensation to obtain an alpha, beta-unsaturated cyclohexanone intermediate, and then subjected to aromatization and decarboxylation under the action of bromine and DMF in one pot to obtain 5-amyl resorcinol (J.org.chem., 1977,42,21). This route also produces polybrominated substituents when brominated with equivalent amounts of bromine, resulting in purification difficulties and difficulty in obtaining a high purity product meeting market demand.
Route three
The Bn protected 3, 5-dihydroxybenzaldehyde is subjected to Witting reaction, debenzylation and reductive hydrogenation to obtain 5-amyl resorcinol (Journal of Chemical Research 2009,183). This route has a problem in that the raw materials are not commercially available and are not suitable as starting materials for the industrial production of 5-amylresorcinol.
Route four
The bromo-methyl protected resorcinol compound is subjected to coupling reaction, reductive hydrogenation and demethylation in sequence to give 5-amyl resorcinol (European Journal of Medicinal Chemistry 2020,204,112620). The route utilizes an expensive metal palladium catalyst and a large amount of boron tribromide, which is not beneficial to industrial production.
In summary, the existing synthesis method has many disadvantages, such as low total yield, high cost, many byproducts, difficult purification, many wastes, and the like, and is not suitable for industrial production.
Disclosure of Invention
Technical problem
The invention aims to provide a synthesis method of 5-alkyl resorcinol compounds, which reduces the catalyst consumption, reduces the generation of reaction waste, improves the total yield of target products, and is suitable for industrial mass production.
Technical proposal
In one aspect, the present application provides a method for preparing a 5-alkylresorcinol compound represented by formula (1), comprising the steps of:
under the action of a catalyst and persulfate, carrying out dehydroaromatization reaction on the compound shown in the formula (2) to obtain the 5-alkyl resorcinol compound shown in the formula (1):
wherein in the formula (1) and the formula (2), R 1 Selected from C 1 ～C 10 Linear or branched alkyl; r is R 2 Selected from hydrogen, -CO 2 R, wherein R is selected from C 1 ～C 10 Straight or branched alkyl, substituted or notSubstituted benzyl, substituted or unsubstituted C 6 ～C 10 One of the aryl groups, the substituted benzyl or the substituent in the substituted aryl group can be one or more and can be selected from methoxy and halogen;
wherein the catalyst can be one or more than two of iodine, potassium iodide, sodium iodide, bromine, potassium bromide and sodium bromide.
In a specific embodiment, in formula (1) and formula (2), R 1 Is one selected from methyl, ethyl, n-propyl, n-butyl and n-pentyl.
In a specific embodiment, in formula (1) and formula (2), R 2 Is hydrogen or-CO 2 R, wherein R is selected from C 1 ～C 10 A linear or branched alkyl group, a substituted or unsubstituted benzyl group, a substituted or unsubstituted phenyl group, and a substituted or unsubstituted naphthyl group, the substituted benzyl group may be selected from p-methoxybenzyl, 2, 4-dimethoxybenzyl, and monochlorobenzyl, the substituted phenyl group may be selected from phenyl substituted with methoxy or halogen, and the substituted naphthyl group may be selected from naphthyl substituted with methoxy or halogen; in particular, R 2 Is hydrogen or-CO 2 R is one selected from methyl, ethyl, n-propyl, n-butyl and n-pentyl.
In a specific embodiment, the persulfate may be selected from one or a mixture of two or more of sodium persulfate, potassium persulfate, and ammonium persulfate.
In particular embodiments, the molar ratio of the catalyst to the compound of formula (2) may be from 1:20 to 1:2.5, preferably from 1:20 to 1:5, for example from 1:15 to 1:5 or from 1:10 to 1:5.
In particular embodiments, the molar ratio of persulfate to compound of formula (2) may be from 0.9:1 to 2.0:1, preferably from 1:1 to 1.5:1.
In particular embodiments, the dehydroaromatization reaction is carried out in the presence of a solvent, and the solvent may be selected from one or more of water, methylene chloride, dichloroethane, N-dimethylformamide, N-dimethylacetamide, N-methylpyrrolidone, toluene, xylene, chlorobenzene, acetonitrile, benzonitrile, t-butanol, N-hexane, N-heptane, cyclohexane.
In specific embodiments, the reaction temperature of the dehydroaromatization reaction may be 20 to 120 ℃, preferably 30 to 90 ℃.
In a specific embodiment, the reaction time of the dehydroaromatization reaction may be 3 to 24 hours, preferably 6 to 12 hours.
According to the invention, the halogen includes fluorine, chlorine, bromine, iodine.
Advantageous effects
The invention is characterized in that the method uses cheap and easily available raw materials, and has the advantages of direct oxidation and aromatization under the action of an oxidant and a catalyst, low price and mild reaction conditions. The preparation method of the 5-alkyl resorcinol compound designed by the invention is suitable for industrial production of 5-alkyl resorcinol, and can well meet the market demand for 5-alkyl resorcinol compounds.
The invention uses the easily available chemicals as the initial raw materials to prepare the 5-alkyl resorcinol compounds, has the advantages of easily available raw materials, less byproducts, easy purification and higher total yield in the synthesis process, and is suitable for being developed into an industrial production process.
Detailed Description
The advantages of the present invention will now be further described by the following examples, which are to be understood as being for illustrative purposes only and not limiting the scope of the present invention, as obvious variations and modifications thereof by persons skilled in the art are intended to be included within the scope of the present invention.
Unless specifically indicated otherwise, the starting materials, reagents, methods, and the like used in the present invention are those conventionally or known in the art.
Example 1: preparation of methyl 2, 4-dihydroxy-6-methylbenzoate
2-hydroxy-4-oxo-6-methylcyclohex-2-ene-1-carboxylic acid methyl ester (1.84 g,1.0 eq) and potassium iodide (332 mg,0.2 eq) were placed in a 50mL reaction flask, acetonitrile (10 mL) was added, followed by potassium persulfate (3.24 g,1.2 eq) and stirred at 80℃for 12 hours, and the solids were removed by filtration to reduceAll solvents were removed by concentration under pressure, and column chromatography (petroleum ether, ethyl acetate (100:1-10:1)) gave methyl 2, 4-dihydroxy-6-methylbenzoate (1.31 g, yield 72%). 1 H NMR(500MHz,CDCl3):δ11.73(s,1H),6.29(d,J＝2.5Hz,1H),6.24(t,J＝2.5Hz,1H),5.57(s,1H),3.93(s,3H),2.50(s,3H).ESI m/z:(M+H) + 183.1.
Example 2: preparation of methyl 2, 4-dihydroxy-6-methylbenzoate
Methyl 2-hydroxy-4-oxo-6-methylcyclohex-2-ene-1-carboxylate (1.84 g,1.0 eq) was placed in a 50mL reaction flask, acetonitrile (10 mL) and elemental iodine (255 mg,0.1 eq) were added, potassium persulfate (3.24 g,1.2 eq) was added, stirred at 70℃for 12 hours, the solid was removed by filtration, the whole solvent was removed by concentration under reduced pressure, and column chromatography was performed to give methyl 2, 4-dihydroxy-6-methylbenzoate (1.53 g, yield 84%). 1 H NMR(500MHz,CDCl3):δ11.73(s,1H),6.29(d,J＝2.5Hz,1H),6.24(t,J＝2.5Hz,1H),5.57(s,1H),3.93(s,3H),2.50(s,3H).ESI m/z:(M+H) + 183.1.
Example 3: preparation of methyl 2, 4-dihydroxy-6-n-pentylbenzoate
Methyl 2-hydroxy-4-oxo-6-pentylcyclohex-2-ene-1-carboxylate (2.4 g,1.0 eq) and potassium iodide (332 mg,0.2 eq) were placed in a 50mL reaction flask, acetonitrile (10 mL) was added, potassium persulfate (3.24 g,1.2 eq) was added, stirred at 70℃for 6 hours, the solid was removed by filtration, the whole solvent was removed by concentration under reduced pressure, and column chromatography was performed to give methyl 2, 4-dihydroxy-6-pentylbenzoate (1.42 g, yield 60%). 1 H NMR(400MHz,CDCl 3 ):δ0.9(s,3H),1.2-1.7(b,6H),2.8(m,2H),4.0(s,3H),6.2(s,2H).ESI m/z:(M+H) + 238.1.
Example 4: preparation of methyl 2, 4-dihydroxy-6-n-pentylbenzoate
Methyl 2-hydroxy-4-oxo-6-pentylcyclohex-2-ene-1-carboxylate (1.9 g,1.0 eq) and potassium iodide (270 mg,0.2 eq) were placed in a 50mL reaction flask, toluene (10 mL) was added, followed by potassium persulfate (2.6 g,1.2 eq) and stirring at 80℃for 12 hours, the solids were removed by filtration, all solvents were removed by concentration under reduced pressure, and column chromatography gave methyl 2, 4-dihydroxy-6-pentylbenzoate (833 g, 60% yield). 1 H NMR(400MHz,CDCl 3 ):δ0.9(s,3H),1.2-1.7(b,6H),2.8(m,2H),4.0(s,3H),6.2(s,2H).ESI m/z:(M+H) + 238.1.
Example 5: preparation of methyl 2, 4-dihydroxy-6-n-pentylbenzoate
Methyl 2-hydroxy-4-oxo-6-pentylcyclohex-2-ene-1-carboxylate (2.4 g,1.0 eq) was placed in a 50mL reaction flask, acetonitrile (10 mL) and elemental iodine (255 mg,0.1 eq) were added, potassium persulfate (3.24 g,1.2 eq) was added, stirred at 60℃for 6 hours, the solid was removed by filtration, the whole solvent was removed by concentration under reduced pressure, and column chromatography was performed to give methyl 2, 4-dihydroxy-6-pentylbenzoate (1.90 g, yield 80%). 1 H NMR(400MHz,CDCl 3 ):δ0.9(s,3H),1.2-1.7(b,6H),2.8(m,2H),4.0(s,3H),6.2(s,2H).ESI m/z:(M+H) + 238.1.
Example 6: preparation of ethyl 2, 4-dihydroxy-6-n-pentylbenzoate
Ethyl 2-hydroxy-4-oxo-6-pentylcyclohex-2-ene-1-carboxylate (2.54 g,1.0 eq) was taken in a 50mL reaction flask, acetonitrile (10 mL) and elemental iodine (255 mg,0.1 eq) were added, followed by potassium persulfate (3.24 g,1.2 eq) and stirring at 80℃for 12 hours, the solids were removed by filtration, all solvents were removed by concentration under reduced pressure, and column chromatography gave ethyl 2, 4-dihydroxy-6-pentylbenzoate (2.06 g, yield 82%). ESI M/z (M+H) + 255.3.
Example 7: preparation of methyl 2, 4-dihydroxy-6-n-pentylbenzoate
Methyl 2-hydroxy-4-oxo-6-pentylcyclohex-2-ene-1-carboxylate (2.4 g,1.0 eq) was placed in a 50mL reaction flask, acetonitrile (10 mL) and bromine (160 mg,0.1 eq) were added, sodium persulfate (2.85 g,1.2 eq) was added, stirred at 80℃for 12 hours, the solid was removed by filtration, the whole solvent was removed by concentration under reduced pressure, and column chromatography was performed to give methyl 2, 4-dihydroxy-6-pentylbenzoate (1.55 g, yield 65%). 1 H NMR(400MHz,CDCl 3 ):δ0.9(s,3H),1.2-1.7(b,6H),2.8(m,2H),4.0(s,3H),6.2(s,2H).ESI m/z:(M+H) + 238.1.
Example 8: preparation of methyl 2, 4-dihydroxy-6-n-pentylbenzoate
2-hydroxy-4-oxo-6-n-pentylcyclohex-2-ene-1-carboxylic acid methyl ester (2.4 g,1.0 eq.) was placed in 50mL reactionAcetonitrile (10 mL) and potassium bromide (238 mg,0.2 eq) were added to the flask, followed by sodium persulfate (2.85 g,1.2 eq) and stirring at 90 ℃ for 6 hours, the solid was removed by filtration, and the whole solvent was removed by concentration under reduced pressure, followed by column chromatography to give methyl 2, 4-dihydroxy-6-n-pentylbenzoate (1.38 g, yield 58%). 1 H NMR(400MHz,CDCl 3 ):δ0.9(s,3H),1.2-1.7(b,6H),2.8(m,2H),4.0(s,3H),6.2(s,2H).ESI m/z:(M+H) + 238.1.
Example 9: preparation of 5-n-pentyl-1, 3-benzenediol
3-hydroxy-5-n-pentylcyclohex-2-en-1-one (1.82 g,1.0 eq) was placed in a 50mL reaction flask, acetonitrile (10 mL) and bromine (160 mg,0.1 eq) were added, sodium persulfate (2.85 g,1.2 eq) was added, stirring was performed at 80℃for 12 hours, the solid was removed by filtration, and the whole solvent was removed by concentration under reduced pressure, followed by column chromatography to give 5-n-pentyl-1, 3-benzenediol (0.87 g, yield 70%). 1 H NMR(400MHz,CDCl 3 ):δ6.26(t,J＝2.2Hz,1H),6.19(t,J＝2.2Hz,1H),2.50-2.38(m,2H),1.36-1.21(m,4H),0.87(q,J＝6.6Hz,3H).ESI m/z:(M+H) + 181.2.
Example 10: preparation of 5-n-pentyl-1, 3-benzenediol
3-hydroxy-5-n-pentylcyclohex-2-en-1-one (1.82 g,1.0 eq) was placed in a 50mL reaction flask, acetonitrile (10 mL) and elemental iodine (255 mg,0.1 eq) were added, sodium persulfate (2.85 g,1.2 eq) was added, stirring was performed at 80℃for 12 hours, the solid was removed by filtration, and the whole solvent was removed by concentration under reduced pressure, followed by column chromatography to give 5-n-pentyl-1, 3-benzenediol (1.53 g, yield 85%). 1 H NMR(400MHz,CDCl 3 ):δ6.26(t,J＝2.2Hz,1H),6.19(t,J＝2.2Hz,1H),2.50-2.38(m,2H),1.36-1.21(m,4H),0.87(q,J＝6.6Hz,3H).ESI m/z:(M+H) + 181.2.
Claims (10)
1. A preparation method of 5-alkyl resorcinol compounds comprises the following steps:
under the action of a catalyst and persulfate, carrying out dehydroaromatization reaction on the compound shown in the formula (2) to obtain the 5-alkyl resorcinol compound shown in the formula (1):
wherein in the formulas (1) and (2),
R 1 selected from C 1 ～C 10 Linear or branched alkyl;
R 2 selected from hydrogen, -CO 2 R, wherein R is selected from C 1 ～C 10 Straight-chain or branched alkyl, substituted or unsubstituted benzyl, substituted or unsubstituted C 6 ～C 10 One of the aryl groups, the substituted benzyl or the substituent in the substituted aryl group may be one or more and is selected from methoxy, halogen;
wherein the catalyst is selected from one or more than two of iodine, potassium iodide, sodium iodide, bromine, potassium bromide and sodium bromide.
2. The method according to claim 1, wherein, in the formula (1) and the formula (2), R 1 Is one selected from methyl, ethyl, n-propyl, n-butyl or n-pentyl.
3. The method according to claim 1, wherein, in the formula (1) and the formula (2), R 2 Is hydrogen or-CO 2 R, wherein R is selected from C 1 ～C 10 Straight or branched alkyl, substituted or unsubstituted benzyl, substituted or unsubstituted phenyl, and substituted or unsubstituted naphthyl,
wherein the substituted benzyl is selected from the group consisting of p-methoxybenzyl, 2, 4-dimethoxybenzyl, and monochlorobenzyl, the substituted phenyl is selected from the group consisting of phenyl substituted with methoxy or halogen, and the substituted naphthyl is selected from the group consisting of naphthyl substituted with methoxy or halogen.
4. The method according to claim 1, wherein, in the formula (1) and the formula (2), R 2 Is hydrogen or-CO 2 R is one selected from methyl, ethyl, n-propyl, n-butyl and n-pentyl.
5. The method according to claim 1, wherein the persulfate is one or a mixture of two or more selected from the group consisting of sodium persulfate, potassium persulfate, and ammonium persulfate.
6. The process according to claim 1, wherein the molar ratio of the catalyst to the compound of formula (2) is from 1:20 to 1:2.5, preferably from 1:20 to 1:5, such as from 1:15 to 1:5 or from 1:10 to 1:5.
7. The process according to claim 1, wherein the molar ratio of persulfate to compound of formula (2) is from 0.9:1 to 2.0:1, preferably from 1:1 to 1.5:1.
8. The process of claim 1, wherein the dehydroaromatization reaction is carried out in the presence of a solvent and the solvent is selected from one or more of water, methylene chloride, dichloroethane, N-dimethylformamide, N-dimethylacetamide, N-methylpyrrolidone, toluene, xylene, chlorobenzene, acetonitrile, benzonitrile, t-butanol, N-hexane, N-heptane, cyclohexane.
9. The process according to claim 1, wherein the dehydroaromatization reaction has a reaction temperature of 20 to 120 ℃, preferably 30 to 90 ℃.
10. The process according to claim 1, wherein the dehydroaromatization reaction has a reaction time of 3 to 24 hours, preferably 6 to 12 hours.
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