CN117339093B

CN117339093B - Internal medicine feeding device

Info

Publication number: CN117339093B
Application number: CN202311503768.6A
Authority: CN
Inventors: 毕方成; 毕胜成; 孟荣华; 陈春晓; 王双
Original assignee: Taipingyang Kangtai Scientific Apparatus Jinan Co ltd
Current assignee: Taipingyang Kangtai Scientific Apparatus Jinan Co ltd
Priority date: 2023-11-13
Filing date: 2023-11-13
Publication date: 2024-04-09
Anticipated expiration: 2043-11-13
Also published as: CN117339093A

Abstract

The invention relates to an internal drug delivery device, which comprises an inner tube and an outer tube. The outer tube is formed with at least one axial passageway and a shank at the left end of the tube body. The inner tube can be arranged in a channel on the outer tube in a penetrating way and can axially move relative to the outer tube. The left end of the inner tube is formed with a first grip block and the first grip block can be maintained in a state of relatively protruding outside the outer tube, and the right end can be selectively protruded outside the outer tube. The right-hand end of the inner tube is formed with an end section at the end of the right-hand balloon segment of the plurality of balloon tubes Duan Ju. A plurality of medium flow passages are formed on the wall of the inner tube and are correspondingly communicated with the bag tube sections respectively. After the medium is filled into the bag tube sections, each bag tube section can be deformed into a straight tube and a bent tube which is bent towards the direction which is not completely consistent. By means of the deformation capability of the plurality of balloon catheter sections, the orientation of the end sections can be adjusted, and the purpose of aligning the end sections and gradually inserting the end sections into the oviduct is achieved. The patent can improve the in-vivo administration condition and promote the treatment effect of the medicine.

Description

Internal medicine feeding device

Technical Field

The invention relates to the field of drug delivery devices for delivering media such as drugs into or onto a human body, in particular to a drug delivery device capable of implementing drug delivery operation in the human body.

Background

The interventional therapy is a minimally invasive therapeutic means for diagnosing and locally treating focus positions in a human body by introducing precise instruments such as a special catheter into the human body, and is mostly carried out with the aid of medical imaging equipment. The interventional therapy mode combines the digital technology, can enlarge the visual field and shorten the therapy distance.

The operation performance of the medical instrument used in the interventional therapy is important for overcoming the interventional diagnosis and treatment means, such as difficulty in performing interventional diagnosis and treatment and interventional diagnosis and treatment operation, and the achievable diagnosis and treatment effect. The ovarian disease is a gynecological disease widely existing in female patients at present, and the treatment difficulty is mainly that the distance between the medicine and the nearby focus is far after the medicine is delivered through vagina, so that the treatment effect is not ideal, and the effective treatment effect is difficult to achieve.

In view of this, it is urgent to design an interventional drug delivery device for ovaries, which can make the drug directly enter the ovary part and approach the focus position to achieve the effective therapeutic purpose, with reference to the minimally invasive therapeutic principle of the oviduct interventional recanalization.

Disclosure of Invention

In order to improve the in-vivo administration conditions of organs such as ovaries and the like and promote the treatment effect of medicines, the invention provides an in-vivo administration device which can directly deliver medicines to focus positions in the organs such as ovaries, prostates and the like, so that the focus positions form an environment with higher local medicine concentration, thereby being beneficial to improving the effect of the medicines, shortening the time required for the effective effect of the medicines, realizing accurate administration and being beneficial to improving the clinical curative effect.

The technical scheme adopted for solving the technical problems is as follows: an in vivo drug delivery device includes an outer tube and an inner tube.

At least one channel along the axial direction is formed in the tube body of the outer tube, and a handle for holding is formed at the left end of the tube body.

The inner tube can be arranged in a channel on the outer tube in a penetrating way and can axially reciprocate relative to the outer tube.

The left end of the inner tube is formed with a first grip block for gripping and the first grip block can be maintained in a state of relatively extending out of the outer tube, and the right end of the inner tube can be selectively extended out of the outer tube and retracted into the outer tube.

A section of pipe wall near the right end of the inner pipe is formed into a plurality of bag pipe sections, and the end part of the bag pipe section at the outermost side is formed with an end section.

A plurality of medium flow channels along the axial direction of the inner tube are formed on the wall of the inner tube and are respectively communicated with the bag tube sections in a one-to-one correspondence mode, and the inlet ends of the medium flow channels extend to the first handle blocks. Media, such as physiological saline or gas, can be injected into the balloon segment through a media flow channel arranged on the wall of the inner tube.

After the medium is filled into the bag pipe sections, each bag pipe section can be deformed into a straight pipe and a bent pipe which is bent towards the direction which is not completely consistent. Therefore, if the number of the arranged bag tube sections is two, the bending deformation directions of the two bag tube sections are different, and if the number of the arranged bag tube sections is more than three, the bending deformation directions of part of the bag tube sections can be consistent; in general, the directions in which the adjacent two balloon segments are subjected to bending deformation are set to different directions.

It should be noted that: the same direction of bending deformation of the balloon segments does not of course mean that the bending forms a uniform shape. Furthermore, when the balloon tube segment is deformed into a straight tube, it is understood to include the case of a straight tube without any bends and the case of a straight tube with less bends, and not just the case of an absolute straight tube. The specific shape that the balloon segment can be changed is preset during manufacturing, so that the balloon segment can be changed into a straight tube shape or a preset bent tube shape as long as the filled medium reaches a certain amount to change the internal pressure of the balloon body to a certain interval.

The ability of the plurality of balloon catheter segments to deform allows for flexible adjustment of the orientation of the end segments to facilitate the alignment and gradual insertion of the end segments into the fallopian tube.

The medium amount filled in each bag tube can be controlled independently, so that when part of the bag tube sections are kept in a straight tube state, the other part of the bag tube sections can be kept in a bent tube state, and the specific bag tube sections and the specific number of the bag tube sections kept in the straight tube state and the bent tube state can be adjusted and changed at any time according to actual needs.

Under the scheme, the therapeutic drug can be sent to the vicinity of the focus in the ovary through the axial cavity of the inner tube, namely the first axial cavity, and an environment with higher local drug concentration is formed at the focus, so that the accuracy of drug administration is remarkably improved, and the full play of drug administration efficacy is facilitated.

Optionally, the lumen of the end section is formed into a first cavity and a second cavity, the second cavity is directly communicated with the right port of the inner tube, and a plurality of inner flanges distributed at intervals around the circumference are formed on the inner wall at the joint of the first cavity and the second cavity. And a telescopic sleeve which can elastically deform in the axial direction is fixedly arranged at one end, close to the port of the inner tube, in the second cavity. Also included are flexible tubing, hoses and needle assemblies.

The flexible pipe penetrates through the shaft cavity of the inner pipe and the capsule cavities of the capsule pipe sections, the right end of the flexible pipe extends to the first cavity, the left end of the flexible pipe extends to the outside of the inner pipe, and a second handle block for holding operation is formed. The second handle block can be maintained in a state of relatively protruding out of the inner tube. The flexible tube has the capability of transmitting axial pushing force and pulling force, and the flexible tube can elastically deform along with the bending deformation of the bag tube section, in other words, the flexible tube can be pulled to bend when the bag tube section bends.

And the hose penetrates through the shaft cavity of the flexible pipe, so that the right end extends to the first cavity and the left end extends to the outside of the flexible pipe.

A needle assembly including a seat disposed in the first cavity and a needle head secured to the seat. The needle head is correspondingly arranged at the right end of the cavity tube on the seat and is communicated with the cavity tube. The seat is fixedly connected with the right end of the flexible pipe, and the left end of the cavity pipe on the seat is fixedly connected with the hose. A plurality of outer flanges are formed on the side wall of the seat in spaced relation around the circumference.

The seat is axially movable relative to the first cavity to selectively permit the free end of the needle to be switched between retracted into the lumen of the end section and extended out of the lumen of the end section, during which the outer flange is passed through the space between the inner flanges to permit the seat to extend into the second cavity, and screwing the flexible tube to rotate the seat to bring the inner and outer flanges into axial correspondence to inhibit movement of the seat axially into the first cavity.

After the seat stretches into the second die cavity, the telescopic sleeve can be compressed and deformed, and the outer flange can be pushed to press the inner flange, so that the two axially opposite surfaces can be contacted.

The needle head can shuttle in the axle center hole of the telescopic sleeve when the seat moves axially relative to the first cavity.

The flexible tube is screwed to drive the seat to rotate, so that the interval formed between the outer flange and the adjacent inner flange is axially re-corresponding, and the purpose that the seat can be axially retracted into the first cavity and the needle is retracted into the cavity of the end block is achieved.

Optionally, the flexible pipe comprises a skeleton and an envelope layer made of elastic materials, wherein the envelope layer wraps the skeleton inside the envelope layer, and the skeleton can support the envelope layer to form the flexible pipe shaft cavity. The right end of the framework is fixedly connected with the seat.

The armature has the ability to transmit axial pushing and pulling forces, and to elastically deform following the bending of the balloon segment.

Optionally, the skeleton includes a plurality of flexible lead screws that are alternately distributed around the circumference, makes flexible lead screw extend along the axial and makes flexible lead screw right-hand member fixed connection on the seat. The flexible screw rod is made of elastic materials. When no external force is applied, the flexible screw rod can be kept in a straight rod state along the axial direction, and has the capability of elastic deformation, namely, after the flexible screw rod is subjected to other external forces except the force along the axial direction, the rod body of the flexible screw rod can be bent/bent and deformed, and after the external force is removed, the straight rod state can be restored.

After the two ends of the flexible screw rod are subjected to axial acting force, the rod body has a tendency of flexible deformation, but the rod body is simultaneously subjected to elastic blocking action of the coating layer, so that the flexible screw rod has the capability of transmitting axial thrust, and the seat can be driven to move into the second cavity along the axial direction.

Optionally, a plurality of support beam blocks are also included, which are distributed at intervals along the axial direction. The support beam block is annular, and a plurality of through holes along the axial direction are distributed on the annular wall at intervals around the circumference; each through hole on the plurality of support beam blocks which are arranged at intervals along the axial direction can form a plurality of through shaft holes relatively in the axial direction; the flexible screw rods are matched with the through shaft holes in a one-to-one correspondence mode. The inner diameter of the through hole on the supporting beam block is not smaller than the outer diameter of the flexible screw rod.

The walls of the support beam block should be thin and also be encased within the envelope layer. The support beam block can promote the capability of the flexible screw rod or the flexible screw rod group to transmit axial thrust so as to better push the seat to move along the axial direction.

Alternatively, the flexible screw is a relatively thin spring rod, which should have a relatively small tensile deformation capacity. The wires from which the spring rods are made are relatively thin elastic wires.

Optionally, the skeleton comprises a plurality of axial cell bars and a plurality of radial cell bars.

Every four axial unit rods are in a group. In each group, every two axial unit rods are arranged as a pair which is butted in the axial direction, and the two pairs of axial unit rods in each group are oppositely distributed at two ends in the radial direction. Radial directions of two pairs of axial unit rods in two adjacent groups are distributed oppositely, and projections in the axial direction can be crossed into an X shape or a cross shape.

The other end parts of the axial unit rods except the end parts of the axial unit rods fixedly connected with the seat can be spliced at the end parts or the middle parts of the radial unit rods, and a hinge structure can be formed at the splicing part.

Optionally, two first channels and two second channels along the axial direction of the first channels are formed in the tube body of the outer tube, and the inner tube is correspondingly matched with the first channels. The second channel is matched with the ultrasonic probe device and can enable the ultrasonic probe to extend into the outer part of the right end of the outer tube.

Optionally, the lumen of the end section is formed with a first cavity and a second cavity, and the second cavity is directly communicated with the right port of the inner tube. And a plurality of inner flanges distributed at intervals around the circumference are formed on the inner wall of the joint of the first cavity and the second cavity. And an elastic block is filled in the second cavity. Further comprises:

the flexible pipe penetrates through the shaft cavity of the inner pipe and the capsule cavities of the capsule pipe sections, so that the right end of the flexible pipe extends to the first cavity, and the left end of the flexible pipe extends to the outside of the inner pipe and is provided with a second handle block. The flexible tube has the ability to transmit axial pushing and pulling forces and is capable of elastically deforming following the bending of the balloon segment.

The hose penetrates through the shaft cavity of the flexible pipe, so that the right end of the hose extends to the first cavity, and the left end of the hose extends to the outside of the flexible pipe.

The needle assembly comprises a seat arranged in the first cavity and a needle head fixed on the seat, and the needle head is correspondingly arranged at the right end of the cavity tube on the seat and is communicated with the cavity tube. The seat is fixedly connected with the right end of the flexible pipe, and the left end of the cavity pipe on the seat is fixedly connected with the hose. A plurality of outer flanges are formed on the side wall of the seat in spaced relation around the circumference.

The elastic block is always corresponding to the middle part of the needle head, namely the free end of the needle head is always positioned outside the elastic block and is arranged in the end hole of the end section. The elastic block can be a sponge block or an elastic resin block, etc.

The outer flange is able to pass through the space between the inner flanges so that the seat can extend into the second cavity.

The twisting of the flexible tube can drive the seat to rotate, and can selectively switch the outer flange between a corresponding relationship with the inner flanges in the axial direction and a corresponding relationship with the interval between two adjacent inner flanges in the axial direction.

The seat is axially movable relative to the first cavity to selectively permit the free end of the needle to be switched between a retracted condition within the lumen of the end segment and an extended condition outside the lumen of the end segment.

After the seat stretches into the second die cavity, the elastic block can be pressed to deform, so that the elastic block generates acting force for pushing the outer flange to press one side of the inner flange.

The beneficial effects of the invention are as follows: the medicine can improve the administration condition of organs in the body, promote the improvement of the treatment effect of the medicine, can be used in the internal administration treatment process of organs such as the intra-ovarian administration treatment, the intra-prostate administration treatment and the like, is beneficial to improving the accuracy of the administration position, enables local parts near focuses to form a higher medicine concentration environment, and is beneficial to the improvement of the treatment effect.

The in-vivo drug delivery device can directly deliver the drug to focus in organs such as ovaries and the like, so that the focus forms an environment with higher local drug concentration, thereby being beneficial to improving the effect of the drug, shortening the time required by the effect of the drug, realizing accurate drug delivery and being beneficial to improving the clinical curative effect. If the drug is a drug which damages healthy cells of human body, the drug administration mode can also reduce the damage degree of the drug to the human body and reduce the scope of serious damage.

In addition, by arranging the matching structure related to the needle assembly, the accurate administration operation to the inside of a focus can be realized, the accurate determination of administration is further improved, the full play of the efficacy of the administration is promoted, and the damage degree or range of the damage to healthy cells or peripheral areas of the focus is reduced by aiming at the medicament (such as a chemotherapeutic medicament) taking destructiveness as a treatment target; besides the administration, the medicine can also be used in the puncture treatment process; the design of the structure is realized for the contraction action of the needle head under the corresponding proposal, and the puncture to the inner wall of the body or organ can be prevented in the process of extending into the focus position and the process of extracting. Therefore, under the whole scheme, the feeding and removing processes of the needle head integrate the flexibility of azimuth adjustment and the protection, and have important therapeutic significance.

Drawings

Fig. 1 is a schematic view of a partial cross-sectional structure of an embodiment of the present patent (needle assembly in retracted state).

Fig. 2 is a schematic view of a partial cross-sectional structure of an embodiment of the present patent (with the needle assembly in an extended state).

FIG. 3 is a schematic view of a partially enlarged structure of a portion of the balloon segment extending beyond the inner tube and undergoing bending deformation.

Fig. 4 is a schematic view of a partial cross-sectional structure of the lower end section of the embodiment of the present invention (with the needle retracted).

Fig. 5 is a schematic view of a partial cross-sectional structure at the lower end section of the embodiment of the present patent (with the needle in an extended state).

Fig. 6 is a schematic cross-sectional view of the structure shown in fig. 5 A-A.

Fig. 7 is a schematic view of a partial modification of the embodiment shown in fig. 6.

Fig. 8 is a schematic view of a partially enlarged structure of the junction of the ductile body and the seat.

Fig. 9 is a schematic view of a partially enlarged structure of the inner tube at one end of the stem block of the malleable body.

Fig. 10 is a schematic structural diagram of an embodiment of the ductile body according to the present patent.

Fig. 11 is a schematic structural view of another embodiment of the ductile body according to the present patent.

In the figure: 10 an outer tube; 10a handle; 11 a first channel; a second channel 12; 20 inner tubes; 20a first axial lumen; 20b first handle block; a 21-balloon segment; 22 end sections; 221 a first cavity; 222 a second cavity; 223 inner flange; 2231 stop; 224 end holes; 23 injection holes; 24 medium flow channels; 30 flexible tubing; 30a second axial lumen; 30b a second handle block; 31 flexible screw rod; 31a, 31b: an axial unit rod; 31c, 31d: a radial cell rod; 32 coating layers; 33 supporting the beam block; 331 through holes; a 40 hose; a 50-needle assembly; 51 seats; 511 outer flange; 52 needles; 53 telescoping sheath.

Detailed Description

The structures, proportions, sizes, etc. shown in the drawings are shown only in connection with the disclosure of the present invention, and are not intended to limit the scope of the invention, which is defined by the claims, but rather by the terms of modification, variation of proportions, or adjustment of sizes, without affecting the efficacy or achievement of the present invention, should be understood as falling within the scope of the present invention. Also, the terms such as "upper", "lower", "front", "rear", "middle", and the like are used herein for descriptive purposes only and are not intended to limit the scope of the invention for which the invention may be practiced or for which the relative relationships may be altered or modified without materially altering the technical context.

An in vivo administration device as shown in fig. 1 to 11 comprises an outer tube 10, an inner tube 20, a flexible tube 30, hoses, 40 and a needle assembly 50.

Two channels, namely a first channel 11 and a second channel 12, are formed in the tube body of the outer tube 10 along the axial direction thereof. A handle portion 10a for gripping and convenient operation is formed at the left end of the tube body of the outer tube 10.

The inner tube 20 can be inserted into the first channel 11 on the outer tube 10 and can reciprocate in the first channel 11 along the axial direction (i.e. the left-right direction, the same applies hereinafter) relative to the outer tube 10. The lumen of the inner tube 20 is a first lumen 20a as shown, a first grip block 20b for gripping and convenient manipulation is formed at the left end of the inner tube 20 and the first grip block 20a can be maintained in a state of being relatively protruded out of the outer tube 10, and the right end of the inner tube 20 can be selectively protruded out of the outer tube 10 and retracted into the outer tube 10. A wall portion of the inner tube 20 near the right end is formed as a plurality of balloon segments 21, and an end portion 22 is formed at an end portion of the outermost (rightmost) balloon segment 21.

A plurality of medium flow passages 24 are formed on the wall of the inner tube 20 along the axial direction thereof to communicate with (wall cavities of) the bag tube section 21 in one-to-one correspondence, and an inlet end (i.e., an injection hole 23 as shown) of the medium flow passages 24 is extended on the first handle block 20 b. The wall cavity of the balloon pipe section 21 can be inflated or deflated by injecting or extracting medium into or from the wall cavity of the balloon pipe section 21 through a medium flow passage 24 provided on the wall of the inner pipe 20. The medium can be any one of physiological saline or medical gas. After filling the (wall cavities of the) bag tube sections 21 with a medium, each bag tube section 21 can be inflated to be deformed into a straight tube and an elbow tube which is bent and deformed in a direction which is not completely consistent.

It should be noted that: if the number of the balloon segments 21 to be provided is two, the bending deformation directions of the two balloon segments 21 are different, and if the number of the balloon segments to be provided is three or more (three are shown in the drawing), the bending deformation directions of the partial balloon segments 21 can be made uniform; in general, the directions in which the adjacent two bag segments 21 are subjected to bending deformation are set to different directions. The same direction of bending deformation of the balloon segment 21 does not necessarily mean that the shape of the bending is uniform (the bending curvature, the angle of refraction may be different). Further, when the bag section 21 is deformed into a straight tube, it is understood to include a case of a straight tube without any bend and a case of a straight tube with a smaller bend, and not to refer to only an absolute straight tube case.

The specific shape that the balloon segment 21 can be changed is preset during manufacturing, and the balloon segment 21 can be changed into a straight tube shape or a preset bent tube shape as long as the filled medium reaches a certain amount to change the internal pressure of the balloon body to a certain interval.

The ability to deform the plurality of balloon segments 21 allows flexible adjustment of the orientation of the (free end ports) of the end segments 22 to facilitate alignment and gradual insertion of the end segments 22 into the fallopian tubes.

The amount of medium filled in each bag tube 21 can be controlled independently, so that when part of the bag tube sections 21 are kept in a straight tube state, the other part of the bag tube sections 21 are kept in a bent tube state, and the specific bag tube sections and the specific number of the bag tube sections kept in the straight tube state and the bent tube state can be adjusted and changed at any time according to actual needs, so that the orientation of the end sections 22 can be controlled flexibly and at multiple angles.

The above-designed related embodiments of the structural features of the outer tube 10 and the inner tube 20 can achieve the purpose that the therapeutic drug is delivered to the vicinity of the lesion in the ovary through the first axial cavity 20a of the inner tube 20, and can form an environment with higher local drug concentration at the lesion, thereby remarkably improving the accuracy of drug administration and helping to achieve full play of drug administration efficacy.

To better realize the visual operation environment, an ultrasonic probe device is arranged in the second channel 12 in the tube body of the outer tube 10, so that the ultrasonic probe can extend to the outside of the right end of the outer tube 10.

To cooperate with the use of the needle assembly 50 to achieve penetration into a lesion site, more accurate delivery of medication, or for purposes of penetration therapy, the following specific designs may be provided:

the lumen/shaft of the end section 22 is formed as a first cavity 221 and a second cavity 222, and the second cavity 222 is in direct communication with the right port of the inner tube 20 (i.e., the right lumen port of the end section 22, illustrated as end bore 224). Four inner flanges 223 (see fig. 6 and 7) are formed on the inner wall of the junction between the first cavity 221 and the second cavity 222, and the four inner flanges are distributed around the circumference. A telescopic sleeve 53 which can be elastically deformed in the axial direction is fixedly provided in the second cavity 222 at one end which is close to the right end of the inner tube 20.

The flexible tube 30 penetrates through the first shaft cavity 20a of the inner tube 20 and the balloon cavities of the balloon segments 21 (i.e., the axial tube cavities of the balloon segments 21), so that the right end of the flexible tube 30 extends to the first cavity 221, and the left end of the flexible tube 30 extends to the outside of the inner tube 20 and is provided with a second handle block 30b for holding and convenient operation. The second grip block 30b can be maintained in a state of being relatively protruded out of the inner tube 20.

The flexible tube 30 has its wall designed to provide axial pushing and pulling forces, while the flexible tube 30 is elastically deformed following the bending deformation of the balloon segment 21, in other words, the balloon segment 21 is bent to pull or force the bending of the flexible tube 30 (corresponding portion).

The hose 40 penetrates the second shaft cavity 30a of the flexible tube 30, so that the right end of the hose 40 extends to the first cavity 221, the left end of the hose 40 extends to the outside of the flexible tube 30, and a relatively long end length extends outwards relative to the flexible tube 30, so that the hose can be connected with a syringe.

The needle assembly 50 includes a seat 51 capable of being placed in the first cavity 221 and a needle 52 fixed on the seat 51, and the needle 52 is correspondingly arranged on the right end of the cavity tube on the seat 51 and is communicated with the cavity tube.

The seat 51 is fixedly connected to the right end of the flexible tube 30, and the left end of the lumen on the seat 51 is fixedly connected to the flexible tube 40, so that substances such as medicines, puncture extracts and the like can be transported through the second lumen 30a of the flexible tube 40 and the lumen of the needle 52.

Four outer flanges 511 (see fig. 6 and 7) are formed on the side wall of the seat 51 so as to be spaced apart around the circumference. The seat 51 is axially movable relative to the first cavity 221 to selectively permit the free end of the needle 52 to be switched between a retracted condition within the lumen of the end section 22 and an extended condition outside the lumen of the end section 22.

The outer flange 511 is able to be moved through the space formed between two adjacent inner flanges 223, so that the seat 51 can extend into the second cavity 222 and retract into the first cavity 221.

The screwing of the flexible tube 30 can drive the rotation of the seat 51, so as to selectively switch the outer flange 511 between the correspondence in the axial direction with the inner flanges 223 and the correspondence in the axial direction with the interval formed between the adjacent two inner flanges 223. In detail, screwing the flexible tube 30 can drive the seat 51 to rotate (around the counterclockwise direction) so as to bring the inner flange 223 and the outer flange 511 into the opposite relationship in the axial direction, thereby achieving the purpose of preventing the seat 51 from moving axially into the first cavity 221; screwing the flexible tube 30 drives the seat 51 (clockwise) in rotation, enabling the spacing between the outer flange 511 and the adjacent two inner flanges 223 to be axially re-side-to-side, with the aim of axially retracting the seat 51 into the first cavity 221 and the needle 52 into the lumen of the end block 22.

After the seat 51 extends into the second cavity 222, the telescopic sleeve 53 can be compressed (elastically) to deform, so as to push the outer flange 511 to press against the inner flange 223, so that axially opposite surfaces of the seat 51 can be contacted, and a profile matching relationship is formed between the seat 51 and the left port of the telescopic sleeve 53, thus the needle 52 can be firmly fixed relative to the end section 22, and the needle 52 is not easy to shake.

Because needle 52 is not extended from the interior of end segment 22 until it is sufficiently close to the lesion, the length of needle 52 need not be too long, and generally a short needle is used, which is safe to handle, is easy to align, and does not cause unnecessary stabs to the inside wall of the organ during alignment.

During axial movement of the seat 51 relative to the first cavity 221, the needle 52 is able to shuttle through the axial bore of the bellows 53. After the administration or the puncturing is completed, the end of the needle 52 is first withdrawn from the affected part, and the flexible tube 30 is manipulated to adjust the correspondence between the outer flange 511 and the inner flange 223, and then the seat 51 is withdrawn into the first cavity 221, so that the free end of the needle 52 is retracted into the end hole 224 of the end section 22.

Because the right end of the flexible tube 30 and the right end of the hose 40 are both secured to the seat 51, the needle assembly 50 moves axially, and the flexible tube 30 and the hose 40 move axially with the seat 51, while moving axially with respect to the inner tube 20.

Typically, the inner diameter of the first axial cavity 20a of the inner tube 20 is larger than the outer diameter of the flexible tube 30, and the latter can be set to be 0.75 to 0.95 times that of the former; the second shaft cavity 30a of the flexible tube 30 has an inner diameter larger than the outer diameter of the hose 40, and the second shaft cavity can be 1/2 to 2/3 of the first shaft cavity. The wall of the inner tube 20 at the other parts except the part of the balloon segment 21 has certain rigidity, so that the tube body of the inner tube 20 can be kept in a straight tube state, but the capacity of generating elastic (bending) deformation with certain amplitude is not excluded. The hose 40 may be made of an elastic material, so that the tube body has a soft characteristic, and the lumen of the hose 40 should not be easily blocked by bending of the tube body. Moreover, the walls of the hose 40 may have elastic deformability.

As shown in fig. 7, a stopper 2231 is formed at one end of the inner flange 223 on the end surface of the inner flange 223 facing the second cavity 222. When the outer flange 511 and the inner flange 223 are in an axially opposite relationship (rotated around a counterclockwise direction by a certain angle in the illustrated state), the stopper 2231 can serve to prevent the rotation angle of the outer flange 511 relative to the inner flange 223 in the counterclockwise direction, so that the size of the joint surface or the facing surface between the outer flange 511 and the inner flange 223 when they are in an axially opposite relationship (made large enough) can be controlled, and the inner flange 223 can stably block the movement trend of the seat 51 toward the first cavity 221, thereby preventing the seat 51 from axially dislocating when the free end of the needle 52 is forced and from stabbing the inner wall of the organ (outside the affected part).

The number of inner flanges 223 is preferably, but not strictly required, in principle the same as the number of outer flanges 511. The interval length between two adjacent inner flanges 223 in the circumferential direction should be appropriately longer than the length of the outer flange 511 in the circumferential direction, and the difference in length therebetween is not easily excessively large.

As shown in fig. 4 to 11, the flexible tube 30 includes a frame and an envelope layer 32 made of an elastic material, the envelope layer 32 wraps the frame inside the envelope layer, and the frame can support the envelope layer 32 to form a second axial cavity 30a of the flexible tube 30, so that the flexible tube 40 can be prevented from being stuck to the frame. The right end of the skeleton establishes a fixed connection with the seat 51. The armature should be provided with the ability or properties to transmit axial pushing and pulling forces and the ability or properties to elastically deform following the bending of the balloon segment.

As shown in fig. 4 to 9, the skeleton includes a plurality of flexible screw rods 31 (three or six are shown in the drawings, more may be provided in practice) distributed at intervals around the circumference, and the flexible screw rods 31 are extended in the axial direction and the right ends of the flexible screw rods 31 are fixedly connected to the seats 51, so that the left ends of the flexible screw rods 31 are fixed to the second handle block 30b. The flexible screw rod 31 is made of an elastic material. When no external force is applied, the flexible screw rod 31 can be kept in a straight rod state along the axial direction, and can bear the axial thrust and pressure. The flexible screw rod 31 has an elastic deformation capability or property, that is, after the flexible screw rod 31 is subjected to an external force (other acting forces except axial force, such as a flexible acting force, a torque force, etc.), the rod body of the flexible screw rod 31 can be bent/curved and deformed, and after the external force is removed, the rod body can be restored to a straight rod state.

After the two ends of the flexible screw rod 31 are subjected to axial force, the rod body will have a tendency of flexible deformation, but the rod body will also be subjected to elastic blocking action of the coating layer 32, so that the flexible screw rod 31 (or the flexible screw rod set) has the capability of transmitting axial thrust force, so as to drive the seat 51 to move into the second cavity 222 along the axial direction.

As shown in fig. 11, the flexible screw 31 may alternatively be a relatively thin spring rod, which should have a relatively small tensile deformation capacity. The wires from which the spring rods are made are relatively thin elastic wires. The spring rod should be relatively easy to bend and deform. This helps to make the bending change process relatively softer and smoother when the flexible tube 30 is deformed along with the balloon segment 21, and no significant internal stress exists after a plurality of bending positions.

A plurality of support beam blocks 33, which may be axially spaced apart, are mated with the flexible lead screw set.

The support beam block 33 is annular, and a plurality of through holes 331 are distributed on the annular wall at intervals around the circumference along the axial direction. The through holes 331 of the plurality of support blocks 33 that are arranged alternately in the axial direction can be formed to be opposed to each other in the axial direction. The flexible screw rods 31 are matched with the through shaft holes in a one-to-one correspondence mode.

The inner diameter of the through hole 331 on the support beam block 33 is not smaller than the outer diameter of the flexible screw rod 31.

The walls of the support beam block 33 should be thin and also be encased within the envelope layer 32. The support beam block 33 can promote the capability of the flexible screw rod 31 or the flexible screw rod group to transmit axial thrust, and can better push the seat 51 to move along the axial direction and enter the second cavity 222.

As shown in fig. 10, the skeleton includes a plurality of axial unit rods 31a, 31b and a plurality of radial unit rods 31c, 31d.

The axial unit rods 31a, 31b are grouped into one group, as shown, four axial unit rods 31a are grouped into one group, and four axial unit rods 31b are grouped into one group, so that two adjacent groups are formed. In each group, each two axial unit rods 31a, 31b are provided as a pair butted in the axial direction, and the two pairs of axial unit rods 31a, 31b in each group are oppositely distributed at both ends in the radial direction. The radial directions of the two pairs of axial unit rods 31a, 31b in the adjacent two groups are distributed oppositely, and projections in the axial direction can be crossed into a cross shape. The other ends of the axial unit rods 31a, 31b, except for the ends of the axial unit rods 31a, 31b fixedly connected to the seat 51, may be inserted into the ends or the middle of the radial unit rods 31c, 31d, and may form a hinge structure at the insertion portion.

Under the above embodiment, the flexible screw rod 31 is divided into the plurality of axial unit rods 31a, 31b butted in the axial direction, and the end portions of the axial unit rods 31a, 31b are hinged with the end portions or the middle portions of the radial unit rods 31c, 31d, which contributes to reducing the internal stress of bending/buckling deformation of the flexible screw rod group and can effectively transmit the pushing force and the pulling force in the axial direction.

The telescopic sleeve 53 provided in the second cavity 222 may be replaced with an elastic block filled in the second cavity 222. The resilient block is always in correspondence with the middle of the needle 52, i.e. the free end of the needle 52 is always outside the resilient block and is initially placed in the end hole 224 of the end section 22. The elastic block can be a sponge block, an elastic resin block, a polyester fiber block or the like.

After the outer flange 511 extends into the second cavity 222 from the space between the inner flanges 223, the seat 51 can press the elastic block to deform (give way), and at this time, the reaction force (elastic force) of the elastic block acting on the seat 51 can push the outer flange 511 to press the inner flange 223.

The absorption of the lubricating fluid in the elastic block (for example in a sponge block or in a cellular polyester block) significantly reduces the resistance to rotation of the seat 51 with respect to the elastic block. When the seat 51 and the telescopic bush 53 are configured to be matched, on the one hand, it is necessary to prevent the elastic reaction force applied to the seat 51 by the telescopic bush 53 from becoming too large, and on the other hand, the contact area between the opposing faces can be reduced (for example, a line-face matching relationship, a point-face matching relationship, or the like) to reduce the resistance at the time of relative rotation.

The scope of protection of this patent should not be construed restrictively as administration, but also includes use in the administration of puncture therapy to the affected area. The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. The present invention is capable of modifications in the foregoing embodiments, as obvious to those skilled in the art, without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.

Claims

1. An in vivo drug delivery device, characterized by: comprises an inner tube and an outer tube;

at least one channel along the axial direction is formed in the tube body of the outer tube, and a handle is formed at the left end of the tube body;

the inner pipe can be arranged in a channel on the outer pipe in a penetrating way and can move axially relative to the outer pipe;

the left end of the inner tube is provided with a first handle block, the first handle block can be kept in a state of relatively extending out of the outer tube, and the right end can be selectively extended out of the outer tube;

a section of pipe wall near the right end of the inner pipe is formed into a plurality of bag pipe sections, and the end part of the bag pipe section at the outermost side is formed with an end section;

a plurality of medium flow channels along the axial direction are formed on the wall of the inner tube and are respectively communicated with the bag tube section correspondingly, and the inlet ends of the medium flow channels extend to the first handle block;

after filling the medium into the bag pipe sections, each bag pipe section can be deformed into a straight pipe and a bent pipe which is bent towards the direction which is not completely consistent; the orientation of the end sections can be adjusted by means of the deformation capability of the plurality of balloon tube sections, so that the end sections can be aligned and gradually inserted into the oviduct;

the pipe cavity of the end section is provided with a first cavity and a second cavity, and the second cavity is directly communicated with the right port of the inner pipe; a plurality of inner flanges which are distributed at intervals around the circumference are formed on the inner wall of the joint of the first cavity and the second cavity; a telescopic sleeve which can elastically deform in the axial direction is fixedly arranged at one end close to the port of the inner tube in the second cavity; further comprises:

the flexible pipe penetrates through the shaft cavity of the inner pipe and the capsule cavities of the capsule pipe sections, so that the right end of the flexible pipe extends to the first cavity, and the left end of the flexible pipe extends to the outside of the inner pipe and is provided with a second handle block; the flexible pipe has the capability of transmitting axial pushing force and pulling force and can elastically deform along with the bending of the bag pipe section;

the hose penetrates through the shaft cavity of the flexible pipe, so that the right end of the hose extends to the first cavity, and the left end of the hose extends to the outside of the flexible pipe;

the needle assembly comprises a seat arranged in the first cavity and a needle head fixed on the seat, and the needle head is correspondingly arranged at the right end of a cavity tube on the seat and is communicated with the cavity tube; the seat is fixedly connected with the right end of the flexible pipe, and the left end of the cavity pipe on the seat is fixedly connected with the hose; a plurality of outer flanges are formed on the side wall of the seat and are distributed at intervals around the circumference;

the outer flange can pass through the interval between the inner flanges, so that the seat can extend into the second die cavity;

screwing the flexible tube can drive the seat to rotate, and can selectively switch the outer flange between a corresponding relation in the axial direction with the inner flanges and a corresponding relation in the axial direction with the interval between two adjacent inner flanges;

the seat being axially movable relative to the first cavity to selectively enable the free end of the needle to be switched between a retracted condition within the lumen of the end section and an extended condition outside the lumen of the end section;

the seat can press the telescopic sleeve to generate compression deformation after extending into the second cavity, so that the telescopic sleeve generates acting force for pushing the outer flange to press one side of the inner flange.

2. The in vivo administration device according to claim 1, wherein: the flexible pipe comprises a framework and an envelope layer made of elastic materials, wherein the envelope layer wraps the framework in the membrane layer, and the framework can support the envelope layer to form an axial cavity of the flexible pipe; the right end of the framework is fixedly connected with the seat; the armature has the ability to transmit axial pushing and pulling forces, and to elastically deform following the bending of the balloon segment.

3. The in vivo administration device according to claim 2, wherein: the framework comprises a plurality of flexible screw rods which are distributed at intervals around the circumference, so that the flexible screw rods extend along the axial direction and the right end of the flexible screw rods are fixedly connected to the seat;

the flexible screw rod has the capability of being kept in a straight rod state along the axial direction and has the capability of being elastically deformed;

the rod body of the flexible screw rod is blocked by the coating layer when the rod body of the flexible screw rod is in a flexible deformation trend, so that the flexible screw rod has the capability of transmitting thrust in the axial direction.

4. The in vivo administration device as claimed in claim 3, wherein: the device also comprises a plurality of support beam blocks which are distributed at intervals along the axial direction; the support beam block is annular, and a plurality of through holes along the axial direction are distributed on the annular wall at intervals around the circumference;

each through hole on the plurality of support beam blocks which are arranged at intervals along the axial direction can form a plurality of through shaft holes relatively in the axial direction;

the flexible screw rods are matched with the through shaft holes in a one-to-one correspondence mode.

5. The in vivo administration device as claimed in claim 3, wherein: the flexible screw rod is a spring rod.

6. The in vivo administration device according to claim 2, wherein: the framework comprises a plurality of axial unit rods and a plurality of radial unit rods;

every four axial unit rods are in a group; in each group, every two axial unit rods are arranged as a pair which is butted along the axial direction, and the two pairs of axial unit rods in each group are oppositely distributed at two ends in the radial direction;

radial directions of two pairs of axial unit rods in two adjacent groups are distributed oppositely, and projections in the axial direction can be crossed into an X shape or a cross shape;

the other end parts of the axial unit rods are inserted into the end parts or the middle parts of the radial unit rods except the end parts of the axial unit rods fixedly connected with the seat, and a hinge structure can be formed at the inserted part.

7. The in vivo administration device according to claim 1, wherein: two first channels and two second channels along the axial direction of the outer tube are formed in the tube body of the outer tube, and the inner tube is correspondingly matched with the first channels; the second channel is matched with the ultrasonic probe device and can enable the ultrasonic probe to extend into the outer part of the right end of the outer tube.

8. An in vivo drug delivery device, characterized by: comprises an inner tube and an outer tube;

the pipe cavity of the end section is provided with a first cavity and a second cavity, and the second cavity is directly communicated with the right port of the inner pipe; a plurality of inner flanges which are distributed at intervals around the circumference are formed on the inner wall of the joint of the first cavity and the second cavity, and elastic blocks are filled in the second cavity; further comprises:

the elastic block is always corresponding to the middle part of the needle head;

9. The in vivo administration device as claimed in claim 8, wherein: the flexible pipe comprises a framework and an envelope layer made of elastic materials, wherein the envelope layer wraps the framework in the membrane layer, and the framework can support the envelope layer to form an axial cavity of the flexible pipe; the right end of the framework is fixedly connected with the seat; the armature has the ability to transmit axial pushing and pulling forces, and to elastically deform following the bending of the balloon segment.