CN116687533A

CN116687533A - Piston type embryo transfer tube

Info

Publication number: CN116687533A
Application number: CN202310876984.9A
Authority: CN
Inventors: 毕方成; 毕胜成; 任潇宇; 孟荣华; 陈春晓; 王双
Original assignee: Taipingyang Kangtai Scientific Apparatus Jinan Co ltd
Current assignee: Taipingyang Kangtai Scientific Apparatus Jinan Co ltd
Priority date: 2023-07-18
Filing date: 2023-07-18
Publication date: 2023-09-05

Abstract

The invention relates to a piston type embryo transfer tube, which comprises an ingress pipe part, a conduit part and a pushing injection part. The right end of the ingress pipe part can be pre-bent to a certain angle. The catheter part comprises a catheter and a supporting tube sleeved on the left side of the catheter, and the right end of the catheter extends outwards relative to the supporting tube. The injection part comprises a push rod, and a piston body and a handle end which are respectively arranged at two ends of the push rod. The piston body is contacted with the inner wall of the catheter cavity after extending into the catheter cavity of the catheter, and the piston body can be pushed by the push rod to lean against the right end port of the catheter cavity. The push rod is provided with an elastic deformation section, so that the piston body can be bent relative to the push rod. This patent can guarantee in embryo transfer that the embryo fully pushes into uterus, need not to have embryo retention in follow-up inspection pipe again, can shorten the time that the ingress pipe stayed in uterus, helps reducing the stimulation to uterus in the embryo transfer, and helps improving pregnancy rate.

Description

Piston type embryo transfer tube

Technical Field

The invention relates to the technical field of embryo transplantation, in particular to an embryo transplantation tube.

Background

Embryo transfer is the process of transferring embryos to the uterus through the vagina with an embryo transfer tube. Embryo transfer tubes generally include an introduction tube (i.e., an outer tube), a catheter (i.e., an inner tube), a sheath, and the like. The embryo transfer process is roughly: placing the endoscope to expose the cervix, opening the package, taking out the ingress pipe, and stretching the ingress pipe into the cervix through the vagina of the female; opening the catheter package to remove the catheter, and connecting the connector end of the catheter to the syringe; aligning the tip of the catheter with the culture solution in the culture dish, and pulling the injector to suck the embryo with the culture solution; the catheter is extended into the uterus through the ingress pipe cavity of the ingress pipe, and the injector push rod is pushed to push the embryo and the culture solution into the uterus, so that the embryo and the culture solution are attached to the uterus wall; after the catheter is taken out, whether the catheter has embryo residue or not is checked, if no embryo remains, the ingress pipe is taken out, and embryo transplantation is finished. Therefore, there are problems in using the conventional embryo transfer tube: after removal of the catheter, it is necessary to take the catheter to an assisted reproduction laboratory for examination to confirm that the embryo is retained, during which time the introduction tube needs to remain in the uterus.

Disclosure of Invention

Aiming at the problems that the time for staying in the uterus is relatively long and the stimulation to the uterus is heavy in the use of the conventional embryo transfer tube, the invention provides a piston type embryo transfer tube which can ensure that an embryo is fully pushed into the uterus in embryo transfer, does not need to check whether the embryo stays in a conduit or not later, can shorten the time for staying in the uterus of the ingress tube, is beneficial to reducing the stimulation to the uterus in embryo transfer and is beneficial to improving the pregnancy rate.

The technical scheme adopted for solving the technical problems is as follows: a piston embryo transfer tube comprises an ingress pipe part, a conduit part and a pushing injection part.

The right end of the ingress pipe part can be pre-bent to a certain angle. The catheter part comprises a catheter and a support tube sleeved on the left side of the catheter, and the right end of the catheter extends outwards relative to the support tube, so that the right end of the catheter bends to adapt to the bending part of the ingress pipe when entering the ingress pipe cavity of the pre-bending part of the ingress pipe. The pipe extends to a section outside the support pipe relative to the support pipe, and when the pipe is inserted into the ingress pipe cavity of the ingress pipe and extends into the ingress pipe pre-bending section part, the pipe is bent in a proper state, so that the right end port of the pipe cavity is close to the right end port of the ingress pipe cavity.

The injection part comprises a push rod, and a piston body and a handle end which are respectively arranged at two ends of the push rod.

The piston body stretches into the catheter cavity of the catheter, the outer wall of the piston body is contacted with the inner wall of the catheter cavity, and the piston body can be pushed by the push rod to lean against the right end port of the catheter cavity, so that a structure similar to a syringe is formed among the push rod, the piston body and the catheter. Compared with the injector, the difference is that the elastic deformation section with a certain axial length is formed at one end of the push rod, which is close to the piston body, and the elastic deformation section can enable the push rod to push and pull the piston body smoothly in the guide pipe cavity of the guide pipe, and enable the piston body to bend relative to the push rod when the piston body moves to the pre-bending section part of the guide pipe, so that the piston body can move towards the right end port of the guide pipe cavity.

The elastically deformable section has axial rigidity and radial toughness. The elastic deformation section enables the piston body to extend into the pre-bending part of the guide pipe entering the guide pipe by bending deformation, and enables the piston body to be sufficiently close to the right end port of the guide pipe cavity of the guide pipe, so that embryos and culture fluid sucked into the guide pipe cavity are all injected into the uterus through the right end port of the guide pipe cavity.

After the elastic deformation section moves out of the ingress pipe pre-bending section, the elastic deformation section can be restored to the original state, so that the push rod is restored to be a straight rod.

Optionally, the elastic deformation section is a section of metal rod or fiber rod, and the outer diameter of the metal rod or fiber rod is smaller than that of the push rod, so that the outer diameter of the metal rod or fiber rod is 1/3 to 1/5 of that of the push rod.

Optionally, the elastically deformable section comprises at least one elastically deformable connecting plate made of metal material or fiber material. Spherical bodies are arranged at two ends of the elastic deformation connecting plate. The push rod is provided with a groove matched with the spherical body, so that the elastic deformation section can rotate around the axis relative to the push rod.

Optionally, the elastically deformable section is a balloon lumen including an outer tube and a plurality of vesicles formed in a lumen of the outer tube and communicating with each other, the vesicles being in a balloon shape. The push rod is provided with an axially extending gas delivery pipe cavity communicated with the vesicle.

The handle end is provided with an air bag and a one-way valve arranged at the port of the air delivery pipe cavity, and the air bag can be pressed to continuously send air into the air bag through the air delivery pipe cavity so as to expand the air bag.

The pipe wall of the outer pipe is made of elastic materials.

Optionally, a developing ring is arranged at the right end of the catheter, and is used for helping to judge the position of the implantation tube entering the uterus.

Optionally, a ferrule body is formed at the right end of the ingress pipe.

Optionally, a fixing ring for fixing the ingress pipe at the cervical orifice is arranged on the ingress pipe.

Optionally, an identification line a for indicating the length position is arranged on the outer wall of the ingress pipe; and a marking line b for indicating the distance length is arranged on the catheter part, which corresponds to the catheter part of the supporting tube, near the left end side.

The arrangement of the marking line a and the marking line b can help judge the length of the transplanting tube entering the uterus.

Optionally, the sleeve core part comprises a sleeve core pipe and a supporting wire, and a third seat is arranged at one end of the supporting wire. The support wire can be inserted into the sleeve core tube to keep the sleeve core tube in a branch tube state.

The length of the support wire is smaller than the length of the sleeve core tube, so that the right end of the sleeve core tube does not contain the support wire, the sleeve core tube is made of a flexible material (such as polyurethane, polyethylene or polypropylene), and the support wire is preferably made of a stainless steel material.

When the cervical guide tube is used, the right end of the guide tube is bent to a proper angle in advance, if the cervical condition is bad and the guide tube is difficult to enter the cervical, the sleeve core tube is inserted into the guide tube, and the support wire is not arranged at the front end of the sleeve core tube, so that the pre-bending angle of the front end of the guide tube cannot be changed when the sleeve core tube is inserted.

The beneficial effects of the invention are as follows: this patent helps alleviateing the stimulation degree that causes to the uterus in the embryo transfer, and the purpose that can fully push into the uterus with embryo (including the culture solution) can be realized in embryo transfer in-process to the piston embryo transfer pipe that provides, need not to confirm at follow-up inspection whether there is embryo retention in the pipe any more, so in use can shorten the time length that the ingress pipe needs to stay in the uterus, helps reducing the stimulation that causes to the uterus in the embryo transfer.

Drawings

Fig. 1 is a schematic diagram of a split structure according to a first embodiment of the present disclosure.

Fig. 2 is a schematic diagram of an assembly structure of the first embodiment of the present patent.

Fig. 3 is a schematic cross-sectional view of a push rod according to the first embodiment of the present disclosure.

Fig. 4 is a schematic cross-sectional view of a push rod in the second embodiment of the present disclosure.

Fig. 5 is a schematic cross-sectional view of an assembled structure of a third embodiment of the present patent.

Fig. 6 is a schematic diagram of a split structure of a third embodiment of the present patent.

In the figure: 10 ingress pipe part, 11 ingress pipe, 11a ingress pipe cavity, 12 first seat, 13 fixing ring, 14 mark line a,15 head body; 20 conduit part, 21 conduit, 21a conduit cavity, 22 support tube, 23 mark line b,24 second seat, 25 developing ring; the device comprises a pushing and injecting part 30, a pushing rod 31, a 31a gas transmission pipe cavity, a 32 piston body, a 33 elastic deformation section, a 33a elastic deformation connecting plate, a 33b spherical body, a 34 handle end, a 34a air bag and a 34b one-way valve;

Detailed Description

The structures, proportions, sizes, etc. shown in the drawings are shown only in connection with the disclosure of the present invention, and are not intended to limit the scope of the invention, which is defined by the claims, but rather by the terms of modification, variation of proportions, or adjustment of sizes, without affecting the efficacy or achievement of the present invention, should be understood as falling within the scope of the present invention. Also, the terms such as "upper", "lower", "front", "rear", "middle", and the like are used herein for descriptive purposes only and are not intended to limit the scope of the invention for which the invention may be practiced or for which the relative relationships may be altered or modified without materially altering the technical context.

The piston type embryo transfer tube as shown in fig. 1 to 6 includes an introduction tube portion 10, a tube portion 20, and a push injection portion 30.

The introduction pipe portion 10 includes an introduction pipe 11, a first seat 12 provided at the left end of the introduction pipe 11, a fixing ring 13 provided on the introduction pipe 11, a mark line a provided on the introduction pipe 11, and a header body 15 provided at the right end of the introduction pipe 11. The shape of the head body 15 is similar to that of a mushroom head, and on one hand, the head body plays a role in enlarging cervix, which is beneficial to delivering the ingress pipe 11 into uterus, and on the other hand, the round design of necking can reduce the damage degree of the delivering process to endometrium. The marking line a is provided in the middle of the outer wall of introducing pipe 11 for indicating the length position. The identification lines a are axially distributed at a certain length distance on introducing pipe 11. The right end of introduction tube 11 can be pre-bent at an angle, generally between 5 and 60 degrees, to conform to the physiological structure of the human body, facilitating introduction tube 11 into the uterus.

The catheter section 20 includes a catheter 21, a support tube 22 fitted around the left side of the catheter 21, a marker line b23 provided on the outer wall of the support tube 22 near the left end for indicating the length position, a second seat 24 provided on the left end of the support tube 22, and a developing ring 25 provided on the right end of the catheter 21. The right end of the guide tube 21 relatively protrudes to the outside of the support tube 22 and has a certain length. When the support tube 22 is in a form of engagement with the inside of the catheter 21, the identification line b23 is provided on the outer wall of the catheter 21. Therefore, in both cases of cooperation between the support tube 22 and the catheter 21, the arrangement of the identification line b23 thereof can be expressed as: the guide pipe portion 20 is provided with a mark line b23 for indicating a distance length at a position near the left end side of a guide pipe 21 section corresponding to the support pipe 22.

Securing ring 13 is used to secure introduction tube 11 at the cervical orifice. The arrangement of the identification line a14 and the identification line b23 can help to judge the length of the implantation tube entering the uterus. The visualization ring 25 can be used to help determine the location of the graft into the uterus.

The pipe 21 is bent in a proper manner so that the right end port of the pipe chamber 21a is brought into contact with the right end port of the introducing pipe chamber 11a when the pipe 21 is inserted into the introducing pipe chamber 11a of the introducing pipe 11 and is inserted into the portion of the introducing pipe 11 where the pipe is bent in advance, at a portion of the supporting pipe 22 extending outside the supporting pipe 22.

The injection part 30 comprises a push rod 31, a piston body 32 and a handle end 34 which are respectively arranged at two ends of the push rod 31.

After the piston body 32 is inserted into the guide tube cavity 21a of the guide tube 21, the outer wall of the piston body 32 is in contact with the inner wall of the guide tube cavity 21a, and the piston body 32 can be pushed by the push rod 31 to lean against the right end port of the guide tube cavity 21a, so that a syringe-like structure is formed among the push rod 31, the piston body 32 and the guide tube 21. The difference from the syringe is that the end of the push rod 31 near the piston body 32 is formed with an elastically deformed section 33 having a certain axial length, and the elastically deformed section 33 allows the push rod 31 to smoothly push and pull the piston body 32 in the guide tube chamber 21a of the guide tube 21, and allows the piston body 32 to bend relative to the push rod 31 when the piston body 32 moves to the pre-bent section portion of the guide tube 11 when the guide tube 21 enters the guide tube 11, so that the piston body 32 can move and lean against the right end port of the guide tube chamber 11 a.

The elastically deformable section 33 has rigidity in the axial direction and toughness in the radial direction. The elastic deformation section 33 allows the piston body 32 to extend into the pre-bent portion of the guide tube 21 into the introduction tube 11 by bending deformation, and allows the piston body 32 to be sufficiently close to the right end port of the guide tube chamber 21a of the guide tube 21, so that the embryo and the culture medium sucked into the guide tube chamber 21a are all injected into the uterus through the right end port of the introduction tube chamber 11 a.

After the elastically deformed section 33 is moved out of the pre-bent section of the introduction pipe 11, the push rod 31 can be restored to the original state to be a straight rod.

As shown in fig. 3, the elastically deformable section 33 is a section of metal rod or fiber rod, and the outer diameter of the metal rod or fiber rod is smaller than the outer diameter of the push rod 31, so that the outer diameter of the metal rod or fiber rod is 1/3 to 1/5 of the outer diameter of the push rod 31.

As shown in fig. 4, the elastically deformable section 33 includes three elastically deformable connecting plates 33a made of metal or fiber materials. Spherical bodies 33b are provided at both ends of the elastically deformable connecting plate 33a. A groove matching with the spherical body 33b is formed in the push rod 31 so that the elastically deformed section 33 can rotate around an axis with respect to the push rod 31.

The above-described configuration in which the elastically deformable member 33 is rotatable about the axis of the pushrod 31 with respect to the pushrod 31 facilitates the adjustment of the plate surface of the elastically deformable connecting plate 33a by the rotation of the elastically deformable connecting plate 33a when the piston body 32 moves relatively to the pre-bent member, and promotes the bending of the plate surface, so that the piston body 32 is smoothly brought into contact with the right port of the introduction chamber 11a of the introduction pipe 11.

The elastic deformation joint plates 33a are thin plates, and if the number of the elastic deformation joint plates 33a is a plurality, the plate thickness can be made relatively thin, and if the number of the elastic deformation joint plates 33a is a single, the plate thickness can be made relatively large.

As shown in fig. 5 and 6, the elastically deformable section 33 is a balloon lumen including an outer tube and a plurality of vesicles formed in the lumen of the outer tube and communicating with each other, the vesicles being in the form of beads. The push rod 31 is provided with an axially extending air delivery pipe cavity 31a communicated with the vesicle. The handle end 34 is formed with a balloon 34a and a one-way valve 34b arranged at the port of the air delivery pipe cavity 31a, and the balloon can be inflated by pressing the balloon 34a to continuously send air into the balloon through the air delivery pipe cavity 31 a. The pipe wall of the outer pipe is made of elastic materials.

The first seat and the second seat are mainly used for holding or connecting. In use, when the right end of introducing tube 11 is bent to a proper angle in advance and cervical condition is not good and introducing tube 11 is difficult to enter the cervix, a sleeve tube is inserted into introducing tube 21, and the pre-bending angle of the front end of introducing tube 11 is not changed by the insertion of the sleeve tube because the front end of the sleeve tube has no supporting wire. Next, after washing the cervix with the culture medium, introducing tube 11 is placed. The injection part 30 is integrally combined with the catheter 21, the push rod 31 extends into the catheter cavity 21a of the catheter 21, and the piston body 32 is close to the right port of the catheter cavity 21a, so that embryo culture medium is sucked through the right port of the catheter 21. The core tube in introducing tube 11 is taken out, and catheter 21 is inserted into introducing tube 11 up to the implantation site. The (indication) mark lines on introducing tube 11 and catheter 21 can help judge the length of the graft/catheter entering the uterine cavity, and the (B-ultrasonic) developing ring at the front end of catheter 21 can help judge the position of the graft entering the uterine cavity. Finally, after catheter 21 is removed from introduction tube 11, introduction tube 11 is removed from the uterus, and the implantation procedure is completed.

The above embodiments are merely illustrative of the principles of the present invention and its effectiveness, and are not intended to limit the invention. The present invention is capable of modifications in the foregoing embodiments, as obvious to those skilled in the art, without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications and variations of the invention be covered by the claims, which are within the ordinary skill of the art, be within the spirit and scope of the present disclosure.

Claims

1. A piston type embryo transfer tube comprises an ingress pipe part and a conduit pipe part; the right end of the ingress pipe part can be pre-bent to a certain angle; the catheter part comprises a catheter and a supporting tube sleeved on the left side of the catheter, and the right end of the catheter extends outwards relative to the supporting tube; the method is characterized in that: the device also comprises a pushing injection part, wherein the pushing injection part comprises a push rod, a piston body and a handle end which are respectively arranged at two ends of the push rod;

the piston body is contacted with the inner wall of the catheter cavity after extending into the catheter cavity of the catheter, and can be pushed by the push rod to lean against the right end port of the catheter cavity;

the push rod is provided with an elastic deformation section with a certain axial length, the elastic deformation section can enable the push rod to push and pull the piston body smoothly to move in the guide tube cavity, and the piston body can be bent relative to the push rod when the piston body moves to a pre-bending section part of the guide tube where the guide tube enters.

2. A piston embryo transfer tube as claimed in claim 1, in which: the elastic deformation section is a section of rod, and the outer diameter of the rod is smaller than that of the push rod.

3. A piston embryo transfer tube as claimed in claim 1, in which: the elastic deformation section comprises at least one elastic deformation connecting plate; spherical bodies are arranged at two ends of the elastic deformation connecting plate;

the push rod is provided with a groove matched with the spherical body, so that the elastic deformation section can rotate around the axis relative to the push rod.

4. A piston embryo transfer tube as claimed in claim 1, in which: the elastic deformation section is a vesicle cavity tube, which comprises an outer tube and a plurality of vesicles which are formed in the lumen of the outer tube and are communicated with each other, and the vesicles are in a ball shape;

the push rod is provided with an axially extending gas delivery pipe cavity communicated with the vesicle;

the handle end is provided with an air bag and a one-way valve arranged at the port of the air delivery pipe cavity, and the air bag can be pressed to continuously send air into the vesicle through the air delivery pipe cavity so as to expand the vesicle;

the pipe wall of the outer pipe is made of elastic materials.

5. A piston embryo transfer tube as claimed in any one of claims 1 to 4, in which: the right end of the catheter is provided with a developing ring.

6. A piston embryo transfer tube as claimed in claim 5, in which: the ingress pipe is provided with a fixing ring for fixing the ingress pipe at the cervical orifice.

7. A piston embryo transfer tube as claimed in claim 5, in which: the outer wall of the ingress pipe is provided with a marking line a for indicating the distance length; the guide pipe part is provided with a marking line b which is used for indicating the distance length at the position close to the left end side and corresponds to the guide pipe section of the support pipe.

8. A piston embryo transfer tube as claimed in any one of claims 1 to 4, in which: the right end of the ingress pipe is provided with a packet head body.

9. A piston embryo transfer tube as claimed in any one of claims 1 to 4, in which: the ingress pipe is provided with a fixing ring for fixing the ingress pipe at the cervical orifice.

10. A piston embryo transfer tube as claimed in any one of claims 1 to 4, in which: the outer wall of the ingress pipe is provided with a marking line a for indicating the distance length; the guide pipe part is provided with a marking line b which is used for indicating the distance length at the position close to the left end side and corresponds to the guide pipe section of the support pipe.