CN117298357A - 具有超滑涂层的胆道支架的制备方法 - Google Patents
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Abstract
本发明公开了一种具有超滑涂层的胆道支架的制备方法,包括以下步骤:S1:使用单分散性纳米粒子制备出蛋白石型光子晶体薄膜;S2:将含有石墨烯的聚合物前驱体溶液均匀的渗入所述蛋白石型光子晶体薄膜的孔隙中,聚合后,除去其中的蛋白石型光子晶体结构,得到有序的反蛋白石结构光子晶体薄膜;S3:向附着反蛋白石结构光子晶体薄膜的胆道支架表面滴加浸润液体使其完全浸润,形成液体涂层,得到超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架,具有良好的抗菌和载药性能,药物释放过程可以通过视觉结构的颜色变化来监测。
Description
技术领域
本发明涉及药物运输技术领域,特别涉及一种超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法。这种具有超滑涂层的胆道支架可应用于药物的释放和检测。
背景技术
介入性医疗器械,如血液透析导管、气管插管、胆道支架(BS)等,近年来因其在心血管和肠道疾病的诊断和治疗中的应用越来越受到关注。然而,介入性医疗器械消毒不合格和长期留置已成为患者感染的主要原因。特别是BS在人体内的长期滞留,往往会导致蛋白质的粘附和生物膜的形成,对患者的生命造成严重威胁。为了克服这些问题,人们开发了各种方法,包括使用先进材料、化学改性或在BS表面制造微结构。虽然这些方法有很多突破,但大多数方法的生产成本较高,或只关注BS的主体,忽略了它们的技巧,这对它们的应用有很大的限制。
水凝胶因其优良的生物相容性、广泛的载药范围和药物的持续释放能力在医学领域发挥着不可或缺的作用。许多水凝胶产品在抗菌能力、药物释放能力和促进伤口愈合方面得到了开发。三维反蛋白石型石墨烯光子晶体薄膜是由层状有序的六边形结构构成的,它是通过复制蛋白石型石墨烯光子晶体模版而制备得到的。自然界中就存在这样的三维反蛋白石型光子晶体结构,但是,目前反蛋白石型石墨烯光子晶体结构的工作很少涉及到与介入性医疗机械相结合的层面,将介入性医疗机械与反蛋白石型石墨烯光子晶体薄膜相结合治疗胆道疾病的实验仍然是空白。
发明内容
发明目的:本发明目的在于提供一种具有超滑涂层的胆道支架的制备方法,其制备简单,成本低廉,具有良好的抗菌和载药性能。
技术方案:本发明提供了一种具有超滑涂层的胆道支架的制备方法,其特征在于,包括以下步骤:S1:使用单分散性纳米粒子制备出蛋白石型光子晶体薄膜;S2:将含有石墨烯的聚合物前驱体溶液均匀的渗入所述蛋白石型光子晶体薄膜的孔隙中,聚合后,除去其中的蛋白石型光子晶体结构,得到有序的反蛋白石结构光子晶体薄膜;S3:向附着反蛋白石结构光子晶体薄膜的胆道支架表面滴加浸润液体使其完全浸润,形成液体涂层,得到超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架。
所述聚合物前驱体溶液中,石墨烯的浓度为0.9-3mg/ml。
优选的,在所述S1中,通过竖直沉积法、刮膜法、旋转涂膜法、提拉法、气相沉积法或电沉积法制备所述的蛋白石型光子晶体薄膜。
优选的,在所述S1中,所述单分散性纳米粒子为以下任意一种或其组合:金属氧化物、无机盐、聚电解质、嵌段聚合物、共聚物、液晶材料、介孔纳米粒子、金或银。
优选的,所述单分散性纳米粒子的直径为200nm~400nm,浓度为0.1g/ml~0.3g/ml。
优选的,所述蛋白石型光子晶体薄膜的厚度为400nm~400μm。
优选的,所述的聚合物前躯体溶液可以是甲基丙烯酸甲酯、聚甲基丙烯酸羟乙酯、醋酸丁酸纤维素、硅氧烷甲基丙烯酸酯、氟硅甲基丙烯酸酯、全氟醚、N-乙烯吡咯烷酮、聚乙烯醇、甲基丙烯酸缩水甘油酯、二甲基丙烯酸乙二醇酯、聚二甲基硅氧烷及聚氨酯。
优选的,在所述S2中,所述聚合的方法为热聚合或紫外光聚合。
优选的,在所述S2中,通过酸腐蚀、碱腐蚀或热烧除的方法除去所述蛋白石型光子晶体结构。
优选的,在所述S3中,所述浸润液体为硅油、乙醇或超纯水。
优选的,在所述S3中,所述聚合的方法为热聚合或紫外光聚合。
有益效果:本发明是先使用单分散性纳米粒子制备三维的蛋白石型光子晶体薄膜,然后将含石墨烯的聚合物前驱体溶液均匀的渗入蛋白石型光子晶体薄膜的孔隙中,聚合后,通过牺牲模板法除去蛋白石型光子晶体结构,得到有序的反蛋白石结构光子晶体薄膜,选用合适的浸润液体浸润该薄膜,在其表面形成液体涂层,得到超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架。
本发明制备的具有超滑涂层的胆道支架是基于反蛋白结构光子晶体水凝胶的具有超润滑性的新型胆道支架。反蛋白石结构不仅赋予光滑表面可调的结构颜色,而且为液体吸收提供了充足的空间,如润滑剂和药物。光滑的液体注入多孔表面(slip)赋予光滑表面抗粘附和抗菌性能。由于水凝胶具有良好的温度敏感性,我们可以通过改变温度来控制药物的释放。特别是,药物释放过程可以通过视觉结构的颜色变化来监测。
附图说明
图1为本发明具有超滑涂层的胆道支架的结构示意图。
具体实施方式
下面结合具体实施方式对本发明进行详细的介绍。
实施方式1:
本实施方式提供了一种具有超滑涂层的胆道支架的制备方法,包括以下步骤:
(1)三维的蛋白石型石墨烯光子晶体薄膜的制备:
选择直径300nm、浓度为0.2g/ml的单分散性较好的二氧化硅纳米粒子作为制备蛋白石型光子晶体薄膜的材料,通过竖直沉积法制备得到厚度为400nm的蛋白石型光子晶体薄膜。
(2)反蛋白石型石墨烯光子晶体薄膜的制备:
将浓度为0.9-3g/ml的含石墨烯的聚二甲基硅氧烷(PDMS)前躯体溶液均匀的渗入蛋白石型光子晶体薄膜的孔隙中,热引发聚合后,通过牺牲模板法除去蛋白石型光子晶体结构,得到有序的反蛋白石型石墨烯光子晶体薄膜。
(3)具有超滑涂层的胆道支架的制备:
向反蛋白石型石墨烯光子晶体薄膜表面滴加氟化硅油(FC-70)液体,使薄膜完全浸润,形成液体涂层,得到超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架,如图1。
实施方式2:
本实施方式提供了一种具有超滑涂层的胆道支架的制备方法,包括以下步骤:
(1)三维的蛋白石型石墨烯光子晶体薄膜的制备:
选择直径260nm、浓度为0.3g/ml的单分散性较好的聚苯乙烯纳米粒子作为制备蛋白石型光子晶体薄膜的材料,通过竖直沉积法制备得到厚度为100μ
m的蛋白石型光子晶体薄膜。
(2)反蛋白石型石墨烯光子晶体薄膜的制备:
将浓度为0.9-3g/ml的含石墨烯的聚二甲基硅氧烷(PDMS)前躯体溶液均匀的渗入蛋白石型光子晶体薄膜的孔隙中,热引发聚合后,通过牺牲模板法除去蛋白石型光子晶体结构,得到有序的反蛋白石型石墨烯光子晶体薄膜。
(3)具有超滑涂层的胆道支架的制备:
向反蛋白石型石墨烯光子晶体薄膜表面滴加氟化硅油(FC-70)液体,使薄膜完全浸润,形成液体涂层,得到超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架。
实施方式3:
本实施方式提供了一种具有超滑涂层的胆道支架的制备方法,包括以下步骤:
(1)三维的蛋白石型石墨烯光子晶体薄膜的制备:
选择直径250nm、浓度为0.1g/ml的单分散性较好的石墨烯纳米粒子作为制备蛋白石型光子晶体薄膜的材料,通过竖直沉积法制备得到厚度为100μm的蛋白石型光子晶体薄膜。
(2)反蛋白石型石墨烯光子晶体薄膜的制备:
将浓度为0.9-3g/ml的含石墨烯的甲基丙烯酸羟乙酯(HEMA)前躯体溶液均匀的渗入蛋白石型光子晶体薄膜的孔隙中,热引发聚合后,通过牺牲模板法除去蛋白石型光子晶体结构,得到有序的反蛋白石型石墨烯光子晶体薄膜。
(3)具有超滑涂层的胆道支架的制备:
向反蛋白石型石墨烯光子晶体薄膜表面滴加氟化硅油(FC-70)液体,使薄膜完全浸润,形成液体涂层,得到超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架。
上述实施方式只为说明本发明的技术构思及特点,其目的在于让熟悉此项技术的人能够了解本发明的内容并据以实施,并不能以此限制本发明的保护范围。凡根据本发明精神实质所做的等效变换或修饰,都应涵盖在本发明的保护范围之内。
Claims (11)
1.一种具有超滑涂层的胆道支架的制备方法,其特征在于,包括以下步骤:
S1:使用单分散性纳米粒子制备蛋白石型光子晶体薄膜;
S2:将含有石墨烯的聚合物前驱体溶液均匀的渗入所述蛋白石型光子晶体薄膜的孔隙中,聚合后,除去其中的蛋白石型光子晶体结构,得到有序的反蛋白石型石墨烯光子晶体薄膜;
S3:向所述反蛋白石型石墨烯光子晶体薄膜的表面滴加浸润液体使其完全浸润,形成液体涂层,得超润滑的结构色可调的石墨烯光子晶体薄膜,将其与胆道支架聚合,得到具有超滑涂层的胆道支架。
2.根据权利要求1所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,所述聚合物前驱体溶液中,石墨烯的浓度范围在0.9-3mg/ml。
3.根据权利要求1所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,在所述S1中,通过竖直沉积法、刮膜法、旋转涂膜法、提拉法、气相沉积法或电沉积法制备所述的蛋白石型光子晶体薄膜。
4.根据权利要求1所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,在所述S1中,所述单分散性纳米粒子为以下任意一种或其组合:
金属氧化物、无机盐、聚电解质、嵌段聚合物、共聚物、液晶材料、介孔纳米粒子、金或银。
5.根据权利要求1至3中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,所述单分散性纳米粒子的直径为200nm~400nm,浓度为0.1g/ml~0.3g/ml。
6.根据权利要求1至3中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,所述蛋白石型光子晶体薄膜的厚度为400nm~400μm。
7.根据权利要求1至6中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,所述的聚合物前躯体溶液可以是甲基丙烯酸甲酯、聚甲基丙烯酸羟乙酯、醋酸丁酸纤维素、硅氧烷甲基丙烯酸酯、氟硅甲基丙烯酸酯、全氟醚、N-乙烯吡咯烷酮、聚乙烯醇、甲基丙烯酸缩水甘油酯、二甲基丙烯酸乙二醇酯、聚二甲基硅氧烷及聚氨酯。
8.根据权利要求1至6中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,在所述S2中,所述聚合的方法为热聚合或紫外光聚合。
9.根据权利要求1至6中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,在所述S2中,通过酸腐蚀、碱腐蚀或热烧除的方法除去所述蛋白石型光子晶体结构。
10.根据权利要求1至6中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,在所述S3中,所述浸润液体为氟化硅油、乙醇或超纯水。
11.根据权利要求1至6中任一项所述的超润滑的结构色可调的石墨烯光子晶体薄膜的制备方法,其特征在于,在所述S3中,所述聚合的方法为热聚合或紫外光聚合。
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