CN117297522A - Digestive tract capsule pH detection device - Google Patents
Digestive tract capsule pH detection device Download PDFInfo
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- CN117297522A CN117297522A CN202311318370.5A CN202311318370A CN117297522A CN 117297522 A CN117297522 A CN 117297522A CN 202311318370 A CN202311318370 A CN 202311318370A CN 117297522 A CN117297522 A CN 117297522A
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- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 36
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- 229910052742 iron Inorganic materials 0.000 claims description 18
- 238000000498 ball milling Methods 0.000 claims description 17
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- 238000000034 method Methods 0.000 claims description 14
- OMNKZBIFPJNNIO-UHFFFAOYSA-N n-(2-methyl-4-oxopentan-2-yl)prop-2-enamide Chemical compound CC(=O)CC(C)(C)NC(=O)C=C OMNKZBIFPJNNIO-UHFFFAOYSA-N 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 229910001289 Manganese-zinc ferrite Inorganic materials 0.000 claims description 9
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- 238000007789 sealing Methods 0.000 claims description 3
- -1 carbonyl ferric oxide Chemical compound 0.000 claims 1
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N iron oxide Inorganic materials [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 claims 1
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- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical group CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 5
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00131—Accessories for endoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00147—Holding or positioning arrangements
- A61B1/00158—Holding or positioning arrangements using magnetic field
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/045—Control thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
- A61B1/2736—Gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/07—Endoradiosondes
- A61B5/073—Intestinal transmitters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
- H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
- H01F41/00—Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties
- H01F41/02—Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformers; Apparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils, or magnets
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Power Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Physiology (AREA)
- Manufacturing & Machinery (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a digestive tract capsule pH detection device, which comprises a capsule detector; a magnetic force driving mechanism for driving and controlling the capsule detector; the magnetic driving mechanism comprises a magnetic air bag, the magnetic air bag comprises an air bag, and the inner ring of the air bag is provided with a fold structure; a plurality of inner bags are arranged in the inner cavity of the air bag; the other end of each inner bag is communicated with the outer bag; the inner bag and the outer bag are filled with magnetic slurry; the air bag is provided with an air charging hole which is communicated with the air pump through an air charging pipeline; an electromagnet rod is also arranged in the outer bag. The invention also discloses a preparation method of the magnetic slurry and the magnetic fluid. The invention does not depend on different pH values of the alimentary canal to position, and uses the magnetic force generated by the magnetic force driving mechanism to drive the movement and the positioning of the capsule detector, and is also applicable no matter whether the pH value of the alimentary canal of a patient is normal or not. Also, for critically ill patients, the positioning of the capsule detector in the intestine and the expulsion problem can be solved.
Description
Technical Field
The application belongs to the technical field of medical detection, and designs a pH detection device of a digestive system, in particular to a magnetic force driving mechanism for a digestive tract capsule pH detection device and a preparation method of magnetic slurry and magnetic fluid.
Background
The pH value of the digestive tract is monitored, and the method has important value for the treatment effects of mucous membrane state, flora fixation, absorption of nutrient substances in intestines, intestinal administration and the like.
Capsule medical devices for the digestive tract are increasing: the capsule endoscope is fully called as an intelligent capsule digestive tract endoscope system and can be used for acquiring images of digestive tract surface characteristics; the remote release capsule can finish fixed-point administration in the alimentary canal; also capsules that can be sampled in the digestive tract; the product "Smart pill" (Smart pill) developed by American Diagnostics is specially used for detecting indexes such as pressure, PH value and the like in the digestive tract, and the data are important for diagnosing gastrointestinal motility diseases such as gastroesophageal reflux disease. Smart pill, contains pH detector, baroreceptor equipment, and wherein pH detector is used for locating the position of capsule according to different pH values of alimentary canal, so it is only suitable for patient with normal pH value of alimentary canal to detect whether there is abnormality in the power of alimentary canal. For patients lying in bed for a long time and patients with disturbed intestinal pH, the problem of positioning and discharging the capsule in the body still cannot be solved.
For the difficult problem, an invention patent disclosed by an authorized bulletin number CN103356154B of the second army medical university of the free army of Chinese people, which is a multifunctional capsule endoscope system suitable for the alimentary canal, can be solved; however, in actual use, after the capsule is taken by a subject, the subject is laid on a medical electric bed, a doctor controls a table to control a five-dimensional motion platform and a magnetic head, a magnetic field generated by the magnetic head controls a magnet in the capsule, so that the capsule in the body is controlled to be observed at any position in the digestive tract, meanwhile, a pH value sensor is selected to be started to detect the pH value of the position according to actual detection needs, when the doctor judges that the pH value detection capsule needs to stay at a certain position to make a timing pH value, the subject can wear a waistcoat or a waistband, the position and the number of the magnet in the waistcoat or the waistband are adjusted according to the observed position, so that the magnetic field generated by the portable magnet array of the waistcoat or the waistband reaches optimal distribution, and the magnetic field distribution can keep the position of the capsule in vivo in a specific time, thereby realizing the timing pH value detection of the specific position in the digestive tract. The research on the technology shows that the capsule is driven to move in the digestive tract by only relying on a five-dimensional motion platform and a magnetic head through magnetic spacing, and the magnetic head is not fine enough in motion track control of the capsule, particularly in the intestinal tract, and is far limited. In addition, a certain distance exists between the magnetic head and a patient, the movement track and flexibility of the magnetic head are limited, on one hand, the magnetic head needs to generate a very large magnetic field to drive the capsule to move, and once the capsule is in misoperation, the capsule can be extruded and impacted in the intestinal tract instantly, and very serious discomfort and even pain can be caused to the patient; finally, the capsule in the human body can be positioned only by adjusting the positions and the number of the magnets in the waistbelt or the waistbelt according to the observed position, the adjustment process is very dependent on experience and takes longer time, once the capsule is displaced in the adjustment process, the position is required to be corrected again, the magnets in the waistbelt or the waistbelt are taken down, and the user can feel bad after getting heavy, and the adjustment process is time-consuming and labor-consuming.
Disclosure of Invention
According to the defects existing in the prior art, the invention provides a novel digestive tract capsule pH value detection device, which comprises a capsule detector; a magnetic force driving mechanism for driving and controlling the capsule detector; the magnetic driving mechanism comprises a magnetic air bag, the magnetic air bag comprises an air bag, and a fold structure is arranged on the inner ring of the air bag; a plurality of inner bags are arranged in the inner cavity of the air bag; one end of each inner bag is connected with the inner wall of the air bag close to the fold structure, and the other end of each inner bag is communicated with the outer bag; the inner bag and the outer bag are filled with magnetic slurry; the air bag is provided with an air inflation hole which is communicated with the air pump through an air inflation pipeline; an electromagnet rod is further arranged in the outer bag.
Preferably, the magnetic force air bag is of a circular ring structure, and a lifting plate is correspondingly arranged below the inner side of the magnetic force air bag. Preferably, the inner bag is of a semi-ellipsoidal structure, the long axis direction of the inner bag is arranged along the radial direction of the air bag, and one end of the short axis direction of the inner bag is connected with the inner wall of the air bag, which is close to the fold structure; the other end of the short axis direction of the inner bag is communicated with the outer bag; the outer bag is of a football-shaped structure, and the long axis direction of the outer bag is coaxial with the long axis direction of the inner bag.
Preferably, the ratio of the volume of the outer pouch to the volume of the inner pouch is 3-3.5:1.
preferably, the communication position between two adjacent inner bags and the outer bag is also provided with a vibration ball, and the vibration ball is fixedly connected with the inner wall of the air bag.
Preferably, the magnetic force compensation ring is sleeved on the outer side of the magnetic force air bag; the outer ring of the air bag is connected with the inner ring of the magnetic force compensation ring in a sealing way; the magnetic force compensation ring comprises a shell, wherein an iron medium is arranged in the shell, a magnetic fluid accommodating cavity is formed between the outer wall of the iron medium and the inner wall of the shell, and magnetic fluid is filled in the magnetic fluid accommodating cavity; an electromagnet block is arranged in the iron medium.
Further preferably, the cross section of the iron medium is triangular.
Further preferably, the section of the iron medium is a right triangle, and two right-angle sides corresponding to the iron medium are in contact connection with the inner wall of the shell.
Further preferably, a protruding portion is arranged on the oblique side corresponding to the iron medium, and the protruding portion and the inner wall of the shell form a magnetic fluid accommodating cavity.
Further preferably, the cross section of the protruding portion is arc-shaped.
Further preferably, an exhaust valve is arranged at the upper end of the shell, and the exhaust valve is communicated with the magnetic fluid accommodating cavity; the lower end of the shell is provided with a magnetic fluid input valve and a magnetic fluid output valve, the magnetic fluid input valve and the magnetic fluid output valve are both communicated with the magnetic fluid accommodating cavity, and the magnetic fluid input valve and the magnetic fluid output valve are both externally connected with a peristaltic pump.
The invention also provides a preparation method of the magnetic slurry, which comprises the steps of ball milling manganese zinc ferrite, chitosan quaternary ammonium salt, butyl hydroxy benzoate and water, and defoaming after ball milling is finished to prepare the magnetic slurry.
Further preferably, the rotation direction of the ball mill is maintained during ball milling.
Further preferably, defoaming is performed by adopting a vacuum defoaming mode, and the magnetic slurry is obtained after defoaming is finished.
Further preferably, the manganese-zinc-ferrite is in the form of powder having a particle size d50=1.2 μm and a specific surface area of 13.6m 2 /g。
The invention also provides a preparation method of the magnetic fluid, which comprises the steps of ball milling carbonyl iron oxide, diacetone acrylamide, glycerol and water, and defoaming after ball milling is finished to prepare the magnetic fluid.
Further preferably, the rotation direction of the ball mill is maintained during ball milling.
Further preferably, defoaming is performed by adopting a vacuum defoaming mode, and the magnetic slurry is obtained after defoaming is finished.
Further preferably, the carbonyl iron oxide is in the form of a powder having a particle size d50=0.8 μm and a specific surface area of 32.2m 2 And/g. Compared with the prior art, the invention has the beneficial effects that:
1. the digestive tract capsule pH detection device provided by the invention has the advantages that the capsule detector enters from the oral cavity to be discharged from the rectum, or is input into the capsule detector through a gastroscope to be discharged through the rectum, and the whole detection process can be realized through a magnetic driving mechanism. The capsule detector is provided with a pH value sensor which can measure the pH values of different positions in the digestive tract under the drive of magnetic force. The detection device of the present application may also be considered in the future in combination with positioning techniques for UWB.
2. The invention solves the advancing power problem of the capsule detector by means of external magnetic force drive, and finally the capsule detector can be discharged from rectum very smoothly. It does not depend on different pH values of the digestive tract to position the position, and is applicable to patients no matter whether the pH value of the digestive tract is normal or not. Also, for critically ill patients, the positioning of the capsule detector in the intestine and the expulsion problem can be solved.
3. The annular magnetic force air bag can be adjusted according to the body shape of a patient, so that the magnetic force of the magnetic force driving mechanism for driving or controlling the capsule detector in a spaced mode is adjusted more effectively, more flexibly, and has good magnetic force adjusting effect and good universality.
Drawings
FIG. 1 is a schematic diagram of the capsule detector of the present invention.
Fig. 2 is a schematic structural view of the magnetic driving mechanism of the present invention.
FIG. 3 is a schematic diagram of the magnetic force compensation ring of the present invention.
Fig. 4 is a schematic structural view of the magnetic airbag of the present invention.
Detailed Description
Embodiment-referring to fig. 1, the magnetic driving mechanism of this embodiment is used in combination with a digestive tract capsule pH detection device.
The digestive tract capsule pH detection device comprises a capsule detector, wherein the capsule detector comprises a capsule shell 10, one end of the capsule shell 10 is provided with a transparent end 11, an image acquisition unit 14, a pH value sensor 13 and a permanent magnet 12 are arranged in the capsule shell 10, and the image acquisition unit 14 is opposite to the transparent end 11; the permanent magnet 12 has a spherical structure.
Although the present embodiment describes the related content of the digestive tract capsule pH detection device, it also belongs to the prior art, and specific principles, structures and uses thereof can be referred to and directly used as disclosed in patent document "a multifunctional capsule endoscope system suitable for use in digestive tract" (patent publication No. CN 103356154B).
Referring to fig. 2 and 4, the present embodiment mainly discloses a magnetic driving mechanism for a digestive tract capsule pH detection device, the magnetic driving mechanism includes a circular magnetic air bag 30, and a magnetic compensation ring 20 sleeved outside the magnetic air bag 30.
The magnetic airbag 30 comprises a circular airbag 31, the outer ring of the airbag 31 is in sealing connection with the inner ring of the shell 21, the inner ring of the airbag 31 is provided with a fold structure 34, the inner cavity of the airbag 31 is provided with a plurality of inner bags 33, the inner bags 33 are of semi-ellipsoidal structures, the long axis direction of the inner bags 33 is arranged along the radial direction of the airbag 31, one end of the short axis direction of the inner bags 33 is connected with the inner wall of the airbag 31 close to the fold structure into a whole, the inner cavity of the airbag 31 is also provided with an outer bag 35 communicated with the inner bags 33, and the other end of the short axis direction of the inner bags 33 is communicated with the outer bag 35; the outer bag 35 has a football-shaped structure, and the long axis direction of the outer bag 35 is coaxial with the long axis direction of the inner bag 33; the inside of interior bag 33 and outer bag 35 all is filled with the magma, still installs the electromagnetism stick in the outer bag 35, is provided with the inflation hole on the air bag 31, and the inflation hole is linked together with the air pump through the inflation pipeline, and the gas of inflating is in air cavity 32, and air cavity 32 is located between the outer wall of interior bag 33 and outer bag 35 and the inner wall of air bag 35.
In this embodiment, the semi-ellipsoidal structure refers to a structure obtained by cutting an ellipsoid along the direction of its major axis or minor axis. In this embodiment, the inner bag 33 is a semi-ellipsoidal structure obtained by cutting an ellipsoid along the direction of its minor axis.
The magnetic field generated by the magnetic driving mechanism in this embodiment can generate magnetic force to the permanent magnet 12 in the capsule detector, so that whether the capsule detector moves or stays at a specific position is driven or controlled in a spaced manner.
When the inflatable magnetic force air bag is used, the lifting plate 40 is correspondingly arranged below the hollow in the center of the magnetic force air bag 30, a patient stands above the electric lifting plate 40, and the patient is lifted through the electric lifting plate 40, so that the magnetic force air bag 30 is controlled to be positioned at the waist and abdomen of the patient and is mainly flush with the stomach of the patient, after the patient wears the capsule detector, the capsule detector enters the stomach of the patient, the air bag 31 is inflated and pressurized through inflating and pressurizing the air bag 31, the air bag 31 is shrunken and gradually inflated, and as the periphery of the air bag 31 is limited by the magnetic force compensation ring 20, the inner ring of the air bag 31 is provided with the fold structure 34, and the fold structure can be expanded or extruded and tightened by the air bag 31 in the inflation process, so that the inner ring of the air bag 31 can be clung to the chest and abdomen of the patient, and the space between the outer bag 35, the inner bag 33 and the inner permanent magnet 12 of the capsule detector is shortened to the greatest extent. The magnetic paste in the outer bag 35 and the inner bag 33 becomes an electromagnet to generate magnetic force after the electromagnet rod is electrified, so that the attractive or repulsive magnetic force can be applied to the inner permanent magnet 12 of the capsule detector, the outer bag 35 and the inner bag 33 are symmetrically distributed around a patient and can be arranged into 18 groups, 36 groups, 72 groups and the like, so that the inner permanent magnet 12 of the capsule detector can be controlled more conveniently and flexibly, and the movement track of the capsule detector can be adjusted. Since a gap, that is, a blank area, needs to exist between the adjacent two outer bags 35 (or the inner bag 33), and in addition, deformation may occur when the air bag 31 is inflated, there may be a portion of the outer bag 35 and the inner bag 33 that are distorted or deformed, and thus magnetic field compensation by the magnetic force compensation ring 20 is required.
Example two
This embodiment is a preferred embodiment of the first embodiment, and referring to fig. 4, in the air bag 31, the ratio of the volumes of the outer bag 35 and the inner bag 33 is 3.3:1, the easier such volume ratio is to orient the inward deformation for retraction, thereby clamping the patient, thereby shortening the space between the inner pouch 33 and the patient. Because the slurry within the inner pouch 33 is maintained in a large enough area to be aligned with the patient, the minor axis of the ellipse must be aligned with the patient.
Since the slurry is like a "toothpaste" and if it is not, a large amount of slurry may flow back from the inner pouch 33 into the outer pouch 35, and the inner pouch 33 may not have a stable and sufficient amount of slurry. In the present invention, due to the special structures of the inner bag 33 and the outer bag 35, when the magnetic slurry in the outer bag 35 is extruded by an external force (extrusion force of the upper and lower sides of the outer bag 35), the magnetic slurry easily enters the inner bag 33, and when the inner bag 33 is extruded by a plane perpendicular to the minor axis of the ellipse, the magnetic slurry in the inner bag 33 is not easily poured into the outer bag 35. The specific test is as follows:
if the outer bag 35 is ellipsoidal instead of being football-shaped, the weight is directly used to press against the upper side of the outer bag 35; it was found that under the same 500g pressure, the football-shaped outer pouch 35, in which the magma was more likely to squeeze into the inner pouch 33, increased the weight of the magma in the inner pouch 33 by 32%. If the outer bladder 35 is spherical, it was found that under the same 500g pressure, the football-shaped outer bladder 35 would have a greater tendency for the magma to squeeze into the inner bladder 33, and the weight of the magma in the inner bladder 33 would be increased by 71%.
If the inner bag 33 is hemispherical (obtained by cutting along the diameter of the sphere), the cylinder is used for vertically extruding the surface of the inner bag 33, the extruding force of the cylinder is 0.1bar, the inner bag 33 is filled with magnetic slurry, and the outer bag 35 is free of magnetic slurry; after extrusion, the slurry was cut along the communication port, and the weight of the slurry extruded into the outer bag 35 was measured. It was found that under the same squeezing force, the semi-elliptical inner pouch 33 had less tendency for the slurry to squeeze into the outer pouch 35, 53% less of the slurry weight was squeezed into the outer pouch 35, relative to the hemispherical shape. Also, the semi-ellipsoidal inner pouch 33 has less tendency for the slurry to squeeze into the outer pouch 35 and less than 37% of the slurry weight in the outer pouch 35 than a semi-football shape (cut along the minor axis of a football).
If the volume of the outer bladder 35 is too large, the ratio of the volume of the outer bladder 35 to the volume of the inner bladder 33 is 5:1, the air bag 31 slightly deforms, so that a plurality of inner bags 33 are filled with magnetic slurry in a plurality of outer bags 35; if the volume of the outer bladder 35 is too small, the ratio of the volume of the outer bladder 35 to the volume of the inner bladder 33 is 1:1, the air bag 31 needs to be deformed more, so that the magnetic slurry in the outer bag 35 corresponding to the extrusion deformation position can be filled in the inner bag 33 corresponding to the extrusion deformation position, and both the two situations are not suitable for practical use.
Example III
In this embodiment, referring to fig. 4, because of some patients with excessive thin body, the deformation degree of the outer bag 35 and the inner bag 33 is large, in order to ensure that the magnetic slurry therein is continuously and uniformly distributed, the communication position between the outer bag 35 and the inner bag 33 is a communication port, and the adjacent two communication ports are further provided with vibration balls 36, and the vibration balls 36 are fixedly connected with the inner wall of the air bag 31.
The vibration balls 36 vibrate with a small amplitude when energized, so that the magnetic slurry in the outer bag 35 and the inner bag 33 in the vicinity thereof can be distributed more uniformly in a vibrating manner, and continuity can be effectively maintained.
Example IV
In this embodiment, referring to fig. 2 and 3, the magnetic force compensation ring 20 includes a circular ring-shaped housing 21, a circular ring-shaped iron medium 22 is disposed inside the housing 21, in this embodiment, the cross section of the iron medium 22 is a right triangle, two right-angle sides of the right triangle are both in contact with and fixedly connected with the inner wall of the housing 21, a protruding portion 221 is disposed at a hypotenuse of the iron medium 22, the cross section of the periphery of the protruding portion 221 is arc-shaped, a gap is disposed between the upper end of the protruding portion 221 and the upper end of the housing 21, a gap is disposed between the lower end of the protruding portion 221 and the inner ring of the housing 21, the inner ring of the housing 21 is made of ferromagnetic material, and the rest of the housing 21 can be made of non-magnetic material; the inside of the shell 21 is provided with a magnetic fluid accommodating cavity 23, magnetic fluid is filled in the magnetic fluid accommodating cavity 23, and an electromagnet block is embedded in the iron medium 22.
In specific use, as shown in fig. 3, the inner ring of the air bag 31 is pressed and bound at the waist and abdomen of a patient, and the air bag 31 is pulled into a basin shape through the electric lifting plate 40 to cover the whole abdomen, and the experience is better than that of direct pressing and covering. The outer pocket 35 and the inner pocket 33 are no longer coplanar with the magnetic force compensating ring 20. The magnetic force compensation ring 20 can quantitatively input or output magnetic fluid into the magnetic fluid accommodating cavity 23 through the peristaltic pump, so that the amount of the magnetic fluid in the magnetic fluid accommodating cavity 23 is accurately controlled. Through the height of the magnetic fluid in the magnetic fluid accommodating cavity 23 and the magnetic force and magnetic polarity generated by the electromagnetic iron block in the iron medium 22, in the actual adjustment process, the magnetic field generated in the magnetic fluid accommodating cavity 23 can generate corresponding magnetic force for the capsule detector, if the magnetic force air bag 30 has dead angles for controlling the capsule detector, the magnetic field generated in the magnetic fluid accommodating cavity 23 can not only enable the capsule detector to stay at a certain position in the alimentary canal, but also drive the capsule detector downwards or upwards, but the control precision is not as high as that of the magnetic force air bag 30; the magnetic force compensation ring 20 is used as an auxiliary compensation for the magnetic force air bag 30, the magnetic force air bag 30 and the magnetic force compensation ring can be combined, the control effect is better, and the control dead angle of the magnetic force air bag 30 is eliminated.
The doctor can perform experimental adjustment in the stomach of the patient, and the experimental magnetic force air bag 30 can adjust whether the capsule detector can reach the range of 0-360 degrees (along the circumferential direction of the magnetic force compensation ring 20), the adjustment precision is 1 degree, 2 degrees, 5 degrees, 10 degrees and the like, so that whether the magnetic force compensation ring 20 is started for further compensation adjustment is conveniently selected or not in the follow-up. The magnetic slurry in the outer bag 35 and the inner bag 33 is similar to a magnetic needle after being magnetized, the axial direction of the magnetic slurry can be horizontal, and the later stage is inclined generally (the inclination degree can be realized by adjusting the lifting height of the electric lifting plate 40, the inflation degree in the air bag 31 and the like), so that the moving track of the capsule detector can be accurately controlled by controlling the magnetic force of the magnetic needle in different directions.
The protrusion 221 is arranged, so that the liquid level of the magnetic fluid has larger volume change corresponding to the magnetic fluid under the same change amplitude. If the boss 221 is not provided, the liquid level of the magnetic fluid has smaller volume change under the same variation amplitude. In addition, the cambered surface is arranged, so that the magnetic fluid can flow into the magnetic fluid accommodating cavity 23 more easily.
Example five
In order to facilitate the exhaust, the upper end of the housing 21 is provided with an exhaust valve 25, and the exhaust valve 25 is communicated with the magnetic fluid accommodating cavity 23; the lower end of the shell 21 is provided with a magnetic fluid input valve 24 and a magnetic fluid output valve 26, the magnetic fluid input valve 24 and the magnetic fluid output valve 26 are communicated with the magnetic fluid accommodating cavity 23, and the magnetic fluid input valve 24 and the magnetic fluid output valve 26 are externally connected with a peristaltic pump. The peristaltic pump can quantitatively convey the magnetic fluid into the magnetic fluid accommodating cavity 23 or pump the magnetic fluid out of the magnetic fluid accommodating cavity 23, so that the amount of the magnetic fluid in the magnetic fluid accommodating cavity 23 is conveniently controlled.
Example six
The embodiment is a preferable scheme of the first embodiment, and specifically discloses a method for manufacturing magnetic slurry, which comprises the following steps: 2000g of manganese zinc ferrite, 690g of chitosan quaternary ammonium salt, 130g of butyl hydroxy benzoate and 1160g of water are ball-milled in a ball mill, the rotation direction of the ball mill is kept unchanged during ball milling, ball milling is carried out for 12 hours, defoaming is carried out by adopting a vacuum defoaming mode, and magnetic slurry is obtained after defoaming is finished. Wherein the manganese zinc ferrite is in powder form, the powder granularity D50=1.2 μm, and the specific surface area is 13.6m 2 /g。
The magnetic slurry prepared by the method can generate magnetic force on the whole after being magnetized, and has the property similar to a toothpaste.
The magnetic slurry is tested by adopting a laboratory 150ml short neck triangular funnel, 150ml magnetic slurry is poured into the short neck triangular funnel, and after 30 minutes observation, the magnetic slurry can not leak from the short neck triangular funnel. However, if a 500g weight is used on the surface of the slurry in the short neck triangle funnel, 63ml will flow out within 3 minutes.
Comparative example 1
The amount of butyl oxybenzene in this example was reduced to 20g, the remainder was replaced with methylisothiazolinone, that is, the formulation was: 2000g of manganese zinc ferrite, 690g of chitosan quaternary ammonium salt, 20g of butyl oxybenzene, 110g of methylisothiazolinone and 1160g of water. The remainder was unchanged, and the final product was slurry 1.
The magnetism of the slurry 1 after magnetism is conducted is the same as that of the magnetic slurry prepared in the embodiment, a laboratory 150ml short neck triangular funnel is adopted for testing, 150ml of the slurry 1 is poured into the short neck triangular funnel, and after 10min observation, the slurry 1 is found to leak from the short neck triangular funnel, and the outflow is 21ml; if a weight of 500g is placed on the surface of slurry 1 in a short neck triangle funnel, 98ml will flow out in 3 min.
The butyl oxybenzene has the antibacterial and antiseptic effects, and the purpose of the butyl oxybenzene is to improve the antibacterial and antiseptic properties of the magnetic slurry, after all, the butyl oxybenzene meets the use environment of hospitals. However, it was found that the addition was raised to a certain extent (ratio to manganese zinc ferrite exceeding 5%) so that the slurry formed a "toothpaste-like" character, requiring a certain extrusion force for extrusion.
Comparative example 2
The butyl oxybenzene in this example was replaced with methylisothiazolinone in its entirety, and the remainder was unchanged, to finally prepare slurry 2.
The magnetism of the slurry 2 after magnetism is conducted is the same as that of the magnetic slurry prepared in the embodiment, a laboratory 150ml short neck triangular funnel is adopted for testing, 150ml of the slurry 2 is poured into the short neck triangular funnel, and after 10min observation, the slurry 1 is found to leak from the short neck triangular funnel, and the outflow is 24ml; if a weight of 500g is placed on the surface of slurry 2 in a short neck triangle funnel, 92ml will flow out in 3 min.
That is, at lower levels of addition, the use of butyl oxybenzene or methylisothiazolinone does not result in a "toothpaste" like nature of the slurry. The magnetic slurry with the property is not easy to generate sedimentation and has even magnetic force distribution.
Comparative example 3
The butyl oxybenzene in the embodiment is replaced by chitosan quaternary ammonium salt with the same quality, namely, the formula is as follows: 2000g of manganese zinc ferrite, 820g of chitosan quaternary ammonium salt and 1160g of water, and the balance being unchanged, and finally preparing the slurry 3.
The magnetism of the slurry 3 after magnetization is the same as that prepared in the embodiment, a laboratory 150ml short neck triangular funnel is adopted for testing, 150ml of the slurry 3 is poured into the short neck triangular funnel, and after 10min observation, the slurry 1 is found to leak from the short neck triangular funnel, and the outflow is 19ml; if a weight of 500g is placed on the surface of the slurry 3 in the short neck triangle funnel, 105ml will flow out in 3 minutes.
It can be seen that the addition amount of butyl oxybenzene and methylisothiazolinone is reduced, so that the prepared magnetic slurry does not form a dental cream.
Example seven
The embodiment is a preferable scheme of the fourth embodiment, and specifically discloses a method for manufacturing magnetic fluid, which comprises the following steps:
1000g of carbonyl iron oxide, 70g of diacetone acrylamide, 750g of glycerol and 880g of water are subjected to ball milling in a ball mill, the rotation direction of the ball mill is kept unchanged during ball milling, the ball milling is carried out for 24 hours, defoaming is carried out by adopting a vacuum defoaming mode, and magnetic fluid is obtained after defoaming is finished. Wherein the carbonyl iron oxide is in powder form, the powder particle size D50=0.8 μm, and the specific surface area is 32.2m 2 /g。
When the electromagnet is electrified to generate magnetic force, the magnetic fluid is easy to magnetize.
In addition, the magnetic fluid is not easily adhered to the inner wall of the housing 21, and the specific test is: the method comprises the steps of adopting an aluminum alloy tank to contain magnetic fluid, standing the aluminum alloy tank with the average surface roughness of the inner wall of the aluminum alloy tank being 1.6 mu m for 5min, installing a valve at the bottom of the aluminum alloy tank, opening the valve to drain the magnetic fluid in the aluminum alloy tank, wiping the inner wall of the aluminum alloy tank by using dry non-woven fabrics until all attachments possibly existing on the surface of the inner wall of the aluminum alloy tank are wiped clean, and enabling the attachment rate to be = (m) 1 -m 2 )/S，m 1 For the quality of the non-woven fabric after wiping, m 2 For the quality of the non-woven fabric before wiping, S is the total area of the inner wall of the aluminum alloy groove.
The attachment rate of the magnetic fluid in the embodiment is less than or equal to 88mg/cm 2 This is because a part of the mixture of glycerin and water adheres to the inner wall of the aluminum alloy tank. As a reference, the reference agent is prepared by mixing 750g of glycerol and 880g of water, and the magnetic fluid is replaced by the reference agent, and finallyThe attachment rate of the reference agent was found to be 37mg/cm 2 。
Comparative example 4
All diacetone acrylamide in this example was replaced with glycerol and the final formulation was: 1000g carbonyl iron oxide, 820g glycerol, 880g water, the remainder unchanged, to finally obtain fluid 1. Fluid 1 was tested with reference to the test method for the adhesion rate in this example, and the adhesion rate of fluid 1 was 1975mg/cm 2 。
Comparative example 5
The diacetone acrylamide in this example was replaced with water throughout, and the final formulation was: 1000g carbonyl iron oxide, 750g glycerol, 950g water, the remainder unchanged, to finally obtain fluid 2. Fluid 2 was tested with reference to the test method for the adhesion rate in this example, and the adhesion rate of fluid 2 was 1032mg/cm 2 。
Comparative example 6
The amount of diacetone acrylamide in this example was increased and the final formulation was: 1000g carbonyl iron oxide, 110g diacetone acrylamide, 750g glycerol, 880g water, the remainder unchanged, to finally obtain fluid 3. Fluid 3 was tested with reference to the test method for the adhesion rate in this example, and the adhesion rate of fluid 3 was 93mg/cm 2 。
Comparative example 7
The amount of diacetone acrylamide in this example was reduced and the final formulation was: 1000g carbonyl iron oxide, 50g diacetone acrylamide, 750g glycerol, 880g water, the remainder unchanged, to finally obtain fluid 4. Fluid 4 was tested with reference to the test method for the adhesion rate in this example, and the adhesion rate of fluid 4 was 252mg/cm 2 。
The addition of diacetone acrylamide can obviously reduce the attachment rate of the magnetic fluid on the inner wall of the shell 21, so that the magnetic fluid is not easy to adhere on the inner wall of the shell 21, and the magnetic field in the shell 21 can be uniformly and intensively distributed, which is more beneficial to the magnetic force compensation ring 20 to exert the magnetic force compensation function.
Even if the magnetic fluid slightly subsides in the housing 21, the magnetic force compensation function is not affected, because the permanent magnet 12 is located below the housing 21 in actual use, the occurrence of the subsidence can concentrate the magnetic force to exert the magnetic force control on the permanent magnet 12.
The present invention is not described in detail in the present application, and is well known to those skilled in the art.
The foregoing describes in detail preferred embodiments of the present invention. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention by one of ordinary skill in the art without undue burden. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (13)
1. The utility model provides a alimentary canal capsule pH detection device which characterized in that:
comprises a capsule detector;
a magnetic force driving mechanism for driving and controlling the capsule detector;
the magnetic driving mechanism comprises a magnetic air bag, the magnetic air bag comprises an air bag, and a fold structure is arranged on the inner ring of the air bag; a plurality of inner bags are arranged in the inner cavity of the air bag; one end of each inner bag is connected with the inner wall of the air bag close to the fold structure, and the other end of each inner bag is communicated with the outer bag; the inner bag and the outer bag are filled with magnetic slurry; the air bag is provided with an air inflation hole which is communicated with the air pump through an air inflation pipeline;
an electromagnet rod is further arranged in the outer bag.
2. The digestive tract capsule pH detection device according to claim 1, wherein:
the inner bag is of a semi-ellipsoidal structure, the long axis direction of the inner bag is arranged along the radial direction of the air bag, and one end of the short axis direction of the inner bag is connected with the inner wall of the air bag, which is close to the fold structure; the other end of the short axis direction of the inner bag is communicated with the outer bag;
the outer bag is of a football-shaped structure, and the long axis direction of the outer bag is coaxial with the long axis direction of the inner bag.
3. The digestive tract capsule pH detection device according to claim 1, wherein:
the ratio of the volume of the outer pouch to the volume of the inner pouch is 3-3.5:1.
4. the digestive tract capsule pH detection device according to claim 1, wherein:
and vibrating balls are further arranged at the communication positions of the two adjacent inner bags and the outer bag, and are fixedly connected with the inner wall of the air bag.
5. The digestive tract capsule pH detection device according to claim 1, wherein:
the outer side of the magnetic force air bag is sleeved with a magnetic force compensation ring; the outer ring of the air bag is connected with the inner ring of the magnetic force compensation ring in a sealing way;
the magnetic force compensation ring comprises a shell, wherein an iron medium is arranged in the shell, a magnetic fluid accommodating cavity is formed between the outer wall of the iron medium and the inner wall of the shell, and magnetic fluid is filled in the magnetic fluid accommodating cavity; an electromagnet block is arranged in the iron medium.
6. The digestive tract capsule pH detection device according to claim 5, wherein:
the section of the iron medium is a right triangle, and two right-angle sides corresponding to the iron medium are in contact connection with the inner wall of the shell.
7. The digestive tract capsule pH detection device according to claim 6, wherein:
the magnetic fluid containing cavity is formed by the bulge and the inner wall of the shell.
8. The digestive tract capsule pH detection device of claim 7, wherein:
the cross section of the protruding part is arc-shaped.
9. The digestive tract capsule pH detection device according to claim 5, wherein:
an exhaust valve is arranged at the upper end of the shell and is communicated with the magnetic fluid accommodating cavity; the lower end of the shell is provided with a magnetic fluid input valve and a magnetic fluid output valve, the magnetic fluid input valve and the magnetic fluid output valve are both communicated with the magnetic fluid accommodating cavity, and the magnetic fluid input valve and the magnetic fluid output valve are both externally connected with a peristaltic pump.
10. A method of preparing a magnetic slurry according to any one of claims 1 to 9, characterized in that:
ball milling is carried out on manganese zinc ferrite, chitosan quaternary ammonium salt, butyl hydroxy benzoate and water, and defoaming is carried out in a vacuum defoaming mode after ball milling is finished, so that magnetic slurry is prepared; the rotation direction of the ball mill was kept unchanged during ball milling.
11. The method of manufacturing according to claim 10, wherein:
the manganese-zinc ferrite is in a powder shape, the powder granularity D50=1.2 mu m, and the specific surface area is 13.6m 2 /g。
12. A method of preparing a magnetic fluid according to any one of claims 5 to 9, wherein:
performing ball milling on carbonyl iron oxide, diacetone acrylamide, glycerol and water, and defoaming in a vacuum defoaming mode after ball milling is finished to prepare magnetic slurry; the rotation direction of the ball mill was kept unchanged during ball milling.
13. The method of manufacturing according to claim 12, wherein:
the carbonyl ferric oxide is in powder form, the powder granularity D50=0.8 mu m, and the specific surface area is 32.2m 2 /g。
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311318370.5A CN117297522A (en) | 2023-10-11 | 2023-10-11 | Digestive tract capsule pH detection device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202311318370.5A CN117297522A (en) | 2023-10-11 | 2023-10-11 | Digestive tract capsule pH detection device |
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| CN117297522A true CN117297522A (en) | 2023-12-29 |
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| CN202311318370.5A Pending CN117297522A (en) | 2023-10-11 | 2023-10-11 | Digestive tract capsule pH detection device |
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| CN (1) | CN117297522A (en) |
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2023
- 2023-10-11 CN CN202311318370.5A patent/CN117297522A/en active Pending
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