CN1172723C - Swelled polymer particles filter process for preparing artificial eye holder - Google Patents
Swelled polymer particles filter process for preparing artificial eye holder Download PDFInfo
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- CN1172723C CN1172723C CNB021241341A CN02124134A CN1172723C CN 1172723 C CN1172723 C CN 1172723C CN B021241341 A CNB021241341 A CN B021241341A CN 02124134 A CN02124134 A CN 02124134A CN 1172723 C CN1172723 C CN 1172723C
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- artificial eye
- eye holder
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- 239000002245 particle Substances 0.000 title claims abstract description 13
- 229920000642 polymer Polymers 0.000 title claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 title description 3
- 239000011265 semifinished product Substances 0.000 claims abstract description 40
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000000243 solution Substances 0.000 claims abstract description 17
- 230000008961 swelling Effects 0.000 claims abstract description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000008367 deionised water Substances 0.000 claims abstract description 15
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 15
- 239000012047 saturated solution Substances 0.000 claims abstract description 14
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 9
- 239000000178 monomer Substances 0.000 claims abstract description 9
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 229920000249 biocompatible polymer Polymers 0.000 claims abstract description 6
- 238000000034 method Methods 0.000 claims abstract description 5
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 17
- 238000007789 sealing Methods 0.000 claims description 17
- 239000011148 porous material Substances 0.000 claims description 14
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 239000003999 initiator Substances 0.000 claims description 9
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 8
- 238000001291 vacuum drying Methods 0.000 claims description 7
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 6
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical group CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims description 5
- 235000019400 benzoyl peroxide Nutrition 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- OZAIFHULBGXAKX-UHFFFAOYSA-N 2-(2-cyanopropan-2-yldiazenyl)-2-methylpropanenitrile Chemical group N#CC(C)(C)N=NC(C)(C)C#N OZAIFHULBGXAKX-UHFFFAOYSA-N 0.000 claims description 4
- 229940044192 2-hydroxyethyl methacrylate Drugs 0.000 claims description 4
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 4
- 239000011837 N,N-methylenebisacrylamide Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical group C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 4
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 claims description 3
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 239000013557 residual solvent Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 239000010935 stainless steel Substances 0.000 claims description 3
- RDWSYOVJDBEKDB-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)but-3-enyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C=C)OC(=O)C(C)=C RDWSYOVJDBEKDB-UHFFFAOYSA-N 0.000 claims description 2
- WYGWHHGCAGTUCH-UHFFFAOYSA-N 2-[(2-cyano-4-methylpentan-2-yl)diazenyl]-2,4-dimethylpentanenitrile Chemical compound CC(C)CC(C)(C#N)N=NC(C)(C#N)CC(C)C WYGWHHGCAGTUCH-UHFFFAOYSA-N 0.000 claims description 2
- SFPNZPQIIAJXGL-UHFFFAOYSA-N 2-ethoxyethyl 2-methylprop-2-enoate Chemical compound CCOCCOC(=O)C(C)=C SFPNZPQIIAJXGL-UHFFFAOYSA-N 0.000 claims description 2
- YIVJZNGAASQVEM-UHFFFAOYSA-N Lauroyl peroxide Chemical compound CCCCCCCCCCCC(=O)OOC(=O)CCCCCCCCCCC YIVJZNGAASQVEM-UHFFFAOYSA-N 0.000 claims description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 2
- OBNCKNCVKJNDBV-UHFFFAOYSA-N ethyl butyrate Chemical compound CCCC(=O)OCC OBNCKNCVKJNDBV-UHFFFAOYSA-N 0.000 claims description 2
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 2
- 235000019394 potassium persulphate Nutrition 0.000 claims description 2
- 229940070710 valerate Drugs 0.000 claims description 2
- 239000000463 material Substances 0.000 abstract description 7
- 230000000977 initiatory effect Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229910001873 dinitrogen Inorganic materials 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 210000001508 eye Anatomy 0.000 description 13
- -1 ormolu Substances 0.000 description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- 210000004279 orbit Anatomy 0.000 description 4
- 239000011259 mixed solution Substances 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 125000005395 methacrylic acid group Chemical class 0.000 description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920000520 poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 150000007984 tetrahydrofuranes Chemical group 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 206010061842 Entropion Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007159 enucleation Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 101710108497 p-hydroxybenzoate hydroxylase Proteins 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
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- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The present invention relates to a method of preparing an artificial eye holder by filtering out swelled polymer particles, which belongs to the field of biomedicine. The artificial eye holder of the present invention has the preparation method that 1) a biocompatible polymer is dissolved by solvent to obtain saturated solution; the saturated solution and a sieved pore-forming agent (with the particle diameter of 300 to 600 micrometers) are stirred and mixed, pressed into a sphere in a mould; after the solvent is volatilized, a spherical semi-finished product is obtained; 2) an initiating agent, a cross-linking agent and a polymer monomer are mixed and prepared into swelling solution; 3) the spherical semi-finished product is placed into a bunsen beaker; the solution in step 2 is poured until the spherical semi-finished product is submerged; the spherical semi-finished product is introduced with nitrogen gas, sealed and swelled for 3 to 100 hours; 4) the swelled spherical semi-finished product is taken out, placed into a reaction vessel, introduced with nitrogen gas, sealed and polymerized; 5) the sphere is taken out, immersed into deionized water which is replaced in definite time for 72 hours and taken out to obtain the required artificial eye holder. The artificial eye holder adopts press forming and has the advantages of precise shape and good cavity communication structure. The porosity of the artificial eye holder can be up to more than 80%. The performance of a material is improved greatly by a network structure generated by swelling and polymerization.
Description
Technical field
The invention belongs to biomedical sector, relate to a kind of preparation that is used to fill the artificial eye holder of eye socket and ram method.
Background technology
Artificial eye holder is to carry out after eyeball excise or ophthalmic hold enucleation, and the eye socket volume reduces, and for preventing the eye socket implant that postoperative eye socket deformity, entropion adopt, has the effect of treatment and beauty treatment simultaneously.Once used some materials in early days as glass, ormolu, plastics, cartilage, fat deposit, silicone etc., but all because complication and undesirable in various degree, as: plastics easily skid off, fat deposit easily is absorbed, silicone has rejection etc., the shortcoming of these material maximums is fixing eye muscle, gives ocular prosthesis vigor and vitality.Use at present synthetic material mainly concentrate on porous material such as polyethylene (MEDPORE, porouspolyethylene), aluminium sesquioxide (Al
2O
3), pottery and hydroxyapatite (HA) etc., but these materials are because its surface is hard, so be easy to generate inflammatory reaction.
Summary of the invention
The purpose of this invention is to provide a kind of better biocompatibility that has, be difficult for the preparation method of the artificial eye holder of initiation inflammatory reaction.
The manufacturing process of artificial eye holder of the present invention at first is to make spherical semi-finished product.With the biocompatible polymer dissolution with solvents, make saturated solution earlier, mix with the pore former of the particle diameter that sieves with standard screen in 300 microns~600 micrometer ranges then, wherein saturated solution: pore former=1: 2~3.5 (weight ratio).Said biocompatible polymer is various types of polyurethane and poly--beta-hydroxy alkanoic acid ester (PHA) class material as PAUR, EU, poly butyric ester (PHB), butyric ester-valerate copolymer (PHBV), butyric ester-alkyl caproate copolymer (PHBH) etc.Said solvent is the good solvent such as the oxolane of above-mentioned material, chloroform etc.Said pore former is NaCl, KCl, Na
2CO
3, NH
4HCO
3, NaHCO
3, water soluble particle such as white sugar.
The saturated solution that will add pore former then is poured into and is pressed into ball (mould is that two parts are formed up and down, the groove of one group of dome-type is respectively arranged, and several passages are arranged, and the diameter of groove is between 10 millimeters~30 millimeters) in the stainless steel mould.Then mould is left standstill under 20 ℃ and treated the solvent evaporates rear demoulding in 24 hours, obtain spherical semi-finished product, spherical semi-finished product are carried out the outward appearance finishing, make its neat appearance, put into the vacuum drying oven evacuation again and removed residual solvent in dry 2 hours, promptly obtain spherical semi-finished product.
After making spherical semi-finished product, initiator, cross-linking agent, polymer monomer are mixed mutually, be mixed with swelling solution.Said initiator is a radical initiator, as azodiisobutyronitrile (AIBN), 2,2'-Azobis(2,4-dimethylvaleronitrile) (ABVN), dibenzoyl peroxide (BPO), dilauroyl peroxide, potassium peroxydisulfate, Ammonium persulfate. etc.Said cross-linking agent is N,N methylene bis acrylamide, DIETHYLENE GLYCOL (DVG), vinyl ethylene glycol dimethacrylate (EDMA) etc.Said polymer monomer is methyl acrylic ester and acrylic compounds such as 2-hydroxyethyl methacry-late (HEMA), methyl methacrylate (MMA), methacrylic acid-2-ethoxy ethyl ester (EEMA), methacrylic acid (MA) etc.The formula proportion of above-mentioned three kinds of components is: (weight ratio)
Initiator 0.9%~1.0% cross-linking agent 0.4%~0.5% polymer monomer 98.5%~98.7%
Then spherical semi-finished product are put into a dry beaker, poured into the swelling solution of preparation, flooded spherical semi-finished product, logical nitrogen, sealing, swelling 3~100 hours.Take out the spherical semi-finished product after the swelling again, put into reactor, logical nitrogen, sealing, under 20 ℃~90 ℃, polyreaction 3~36 hours.Or after feeding nitrogen protection, sealing was with ultraviolet or Co60 irradiation 0.5~8 hour.Take out reacted spheroid again, it is soaked into deionized water, under 20 ℃~90 ℃, changed deionized water in per 8 hours, take out after 72 hours, the pore former dissolving is removed, promptly get artificial eye holder of the present invention.
Therefore the manufacturing process of artificial eye holder of the present invention can be stated as:
1. get the pore former of particle diameter in 300 microns~500 micrometer ranges with the standard screen sieve.
2. with the biocompatible polymer dissolution with solvents, make saturated solution, mix with sieve pore former well then, the ratio of saturated solution and pore former is: saturated solution: pore former=1: 2~3.5 (weight ratio) is poured into and is pressed into ball in the stainless steel mould.
3. mould is left standstill at 20 ℃ and treated the solvent evaporates rear demoulding in 24 hours, obtain spherical semi-finished product, spherical semi-finished product are carried out the outward appearance finishing, make its neat appearance, put into the vacuum drying oven evacuation again and removed residual solvent in dry 2 hours.
4. initiator, cross-linking agent, polymer monomer are mixed mutually, be mixed with swelling solution.
5. the spherical semi-finished product that will make are put into a dry beaker, pour the solution of preparation into, flood spherical semi-finished product, logical nitrogen, sealing, swelling 3~100 hours.
6. the spherical semi-finished product after the taking-up swelling are put into reactor, logical nitrogen, and sealing, under 20 ℃~90 ℃, polyreaction 3~36 hours.Or after feeding nitrogen protection, sealing was with ultraviolet or Co60 irradiation 0.5~8 hour.
7. take out reacted spheroid, it is soaked into deionized water, under 20 ℃~90 ℃, changed deionized water in per 8 hours, take out after 72 hours, promptly get required artificial eye holder.
Use method of the present invention, the preparation artificial eye holder has following characteristics and advantage:
1. adopt macromolecule interpenetrating networks thinking to carry out modification, make the compressive strength of porous part that very big raising arranged, but do not influence the biocompatibility of artificial eye holder.
2. the porosity of artificial eye holder can reach more than 80%, and the aperture is adjustable.
3. density of material is little, and soft durometer can be regulated by proportioning, can not produce excessive pressure to the optical fundus.
Description of drawings
Fig. 1 is the profile of spherical semi-finished product mould
Fig. 2 is the profile photo of artificial eye holder.
The specific embodiment
Embodiment 1
1. get the NaCl of particle diameter in 450 microns~520 micrometer ranges by the standard screen sieve.
2. EU saturated solution (solvent is an oxolane) is mixed solution with NaCl: the mass ratio of NaCl is 1: 2, is poured in the mould, and is tightly compacted, obtains spherical semi-finished product through nature volatilization and vacuum drying.
3. get 10 milliliters of methacrylic acids-2-ethoxy ethyl ester (EEMA), 0.1 gram DIETHYLENE GLYCOL, 40 milligrams of AIBN obtain solution in beaker.
4. the spherical semi-finished product after the finishing are placed beaker, add the solution for preparing in 3, to flooding spherical semi-finished product, feed nitrogen protection, sealing, swelling 3 hours.
5. take out spherical semi-finished product, put into beaker, feed nitrogen protection, sealing, under 70 ℃, polymerisation in bulk 24 hours.
6. take out reacted spheroid, be put in the deionized water, under 25 ℃, changed deionized water in per 8 hours, take out after 72 hours.
Embodiment 2
1. get the white sugar of particle diameter in 450 microns~520 micrometer ranges by the standard screen sieve
2. PAUR saturated solution (solvent is an oxolane) and white sugar are mixed solution: the White Sugar Quality ratio is 1: 2.5, is poured in the mould, and is tightly compacted, obtains spherical semi-finished product through nature volatilization and vacuum drying.
3. get 10 milliliters of 2-hydroxyethyl methacry-lates (HEMA), 0.1 gram N,N methylene bis acrylamide, 40 milligrams of ABVN obtain solution in beaker.
4. the spherical semi-finished product after the finishing are placed beaker, add the solution for preparing in 3, to flooding spherical semi-finished product, feed nitrogen protection, sealing, swelling 10 hours.
5. take out spherical semi-finished product, put into beaker, feed nitrogen protection, ultraviolet irradiation 5 hours are used in sealing.
6. take out reacted spheroid, be put in the deionized water, under 25 ℃, changed deionized water in per 8 hours, take out after 72 hours.
Embodiment 3
1. get the NH of particle diameter in 300 microns~400 micrometer ranges by the standard screen sieve
4HCO
3
2. with PHB saturated solution (solvent is a chloroform) and NH
4HCO
3Mix solution: NH
4HCO
3Mass ratio is 1: 3, is poured in the mould, and is tightly compacted, obtains spherical semi-finished product through nature volatilization and vacuum drying.
3. get 7 milliliters of 2-hydroxyethyl methacry-lates (HEMA), 3 milliliters of methacrylic acids (MA), 0.1 gram N,N methylene bis acrylamide, 50 milligrams of Ammonium persulfate .s obtain solution in beaker.
4. the spherical semi-finished product after the finishing are placed beaker, add the solution for preparing in 3, to flooding spherical semi-finished product, feed nitrogen protection, sealing, swelling 36 hours.
5. take out spherical semi-finished product, put into beaker, feed nitrogen protection, sealing, under 60 ℃, polymerisation in bulk 36 hours.
6. take out reacted spheroid, be put in the deionized water, under 25 ℃, changed deionized water in per 8 hours, take out after 72 hours.
Embodiment 4
1. get the KCl of particle diameter in 300 microns~400 micrometer ranges by the standard screen sieve.
2. PHBV saturated solution (solvent is a chloroform) is mixed solution with KCl: the KCl mass ratio is 1: 2, is poured in the mould, and is tightly compacted, obtains spherical semi-finished product through nature volatilization and vacuum drying.
3. get 7 milliliters of 2-hydroxyethyl methacry-lates (HEMA), 3 milliliters of methyl methacrylates (MMA), 0.1 gram DIETHYLENE GLYCOL, 40 milligrams of dibenzoyl peroxides (BPO) obtain solution in beaker.
4. the spherical semi-finished product after the finishing are placed beaker, add the solution for preparing in 3, to flooding spherical semi-finished product, feed nitrogen protection, sealing, swelling 24 hours.
5. take out spherical semi-finished product, put into beaker, feed nitrogen protection, Co60 irradiation (45GY/min) 5 hours are used in sealing.
6. take out reacted spheroid, be put in the deionized water, under 25 ℃, changed deionized water in per 8 hours, take out after 72 hours.
Claims (1)
1. a swollen-state polymerization particle leaches the method that legal system is equipped with artificial eye holder, it is characterized in that being made up of the following step:
1) gets the pore former of particle diameter in 300 microns~600 micrometer ranges with the standard screen sieve; Wherein pore former is NaCl, KCl, Na
2CO
3, NH
4HCO
3, NaHCO
3Any;
2) with the biocompatible polymer dissolution with solvents, make saturated solution, mix with sieve pore former well then, be poured into and be pressed into ball in the stainless steel mould; Wherein biocompatible polymer is a PAUR, EU, poly butyric ester, butyric ester-valerate copolymer, any in butyric ester-alkyl caproate copolymer; Solvent is any in oxolane, the chloroform; Saturated solution wherein: pore former=1: 2~3.5;
3) mould is left standstill at 20 ℃ treated the solvent evaporates rear demoulding in 24 hours, obtain spherical semi-finished product, spherical semi-finished product are carried out the outward appearance finishing, make its neat appearance, put into the vacuum drying oven evacuation again and removed residual solvent in dry 2 hours;
4) initiator, cross-linking agent, polymer monomer are mixed mutually, be mixed with swelling solution; Wherein cross-linking agent is a N,N methylene bis acrylamide, DIETHYLENE GLYCOL, any in the vinyl ethylene glycol dimethacrylate; Wherein initiator is an azodiisobutyronitrile, 2,2'-Azobis(2,4-dimethylvaleronitrile), dibenzoyl peroxide, dilauroyl peroxide, any in potassium peroxydisulfate, the Ammonium persulfate.; Polymer monomer is 2-hydroxyethyl methacry-late, methyl methacrylate, methacrylic acid-2-ethoxy ethyl ester, any in the methacrylic acid; The ratio of initiator, cross-linking agent, polymer monomer is: polymer monomer 98.5%~98.7%, initiator 0.9%~1.0%, cross-linking agent 0.4%~0.5%;
5) the spherical semi-finished product that will make are put into a dry beaker, pour the solution of preparation into, flood spherical semi-finished product, logical nitrogen, sealing, swelling 3~100 hours;
6) take out spherical semi-finished product after the swelling, put into reactor, logical nitrogen, sealing, under 20 ℃~90 ℃, polyreaction 3~36 hours, or after feeding nitrogen protection, sealing was with ultraviolet or Co60 irradiation 0.5~8 hour;
7) take out reacted spheroid, it is soaked into deionized water, under 20 ℃~90 ℃, changed deionized water in per 8 hours, take out after 72 hours, promptly get required artificial eye holder.
Priority Applications (1)
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CNB021241341A CN1172723C (en) | 2002-07-12 | 2002-07-12 | Swelled polymer particles filter process for preparing artificial eye holder |
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Application Number | Priority Date | Filing Date | Title |
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CNB021241341A CN1172723C (en) | 2002-07-12 | 2002-07-12 | Swelled polymer particles filter process for preparing artificial eye holder |
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CN1390608A CN1390608A (en) | 2003-01-15 |
CN1172723C true CN1172723C (en) | 2004-10-27 |
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CN102049063A (en) * | 2010-12-14 | 2011-05-11 | 上海纳米技术及应用国家工程研究中心有限公司 | Material for preparing expandable artificial eye table and application thereof |
CN112107734B (en) * | 2020-09-17 | 2021-09-24 | 浙江大学 | Soft porous silica gel artificial eye holder and preparation method thereof |
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