CN1172696C - Medicine for preventing acute upper respiratory tract infection of children group - Google Patents
Medicine for preventing acute upper respiratory tract infection of children group Download PDFInfo
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- CN1172696C CN1172696C CNB011289600A CN01128960A CN1172696C CN 1172696 C CN1172696 C CN 1172696C CN B011289600 A CNB011289600 A CN B011289600A CN 01128960 A CN01128960 A CN 01128960A CN 1172696 C CN1172696 C CN 1172696C
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention provides medicine for preventing collective acute upper respiratory of children, which is prepared from ten kinds of traditional Chinese medicine, such as honeysuckle flower, weeping forsythia capsule, isatis root, platycodon root, cyrtomium fortunei, ledebouriella root, great burdock achene, blackberrylily rhizome, etc. The medicine solves the prevention problem of upper respiratory tract infection caused by cross infections of collective aggregate plates of children, such as nursery schools, kindergartens, primary schools, etc. The present invention has the advantages of small medication dose, sweet taste, high dependence of children, practicality, convenience and security. In addition, the medicine also has the functions of heat toxic material clearing, cold expelling and exterior security. The immunological functions of human bodies can be improved, and caries actuation bacteria of oral cavities can be killed. If sprayed before children go to hospitals and schools, the medicine for preventing collective acute upper respiratory of children can have better prevention functions.
Description
Technical field
The present invention relates to a kind of medicine, the pure Chinese medicinal preparation-Vaxigrip of especially a kind of treatment and prevention acute upper respiratory tract infection of children group.
Background technology
" flu " that acute upper respiratory tract infection is promptly usually alleged or " go up and feel " are the most common a kind of diseases of children growth phase, mainly show as nasopharyngitis, acute pharyngitis, acute tonsillitis etc., and the person accounts for more than 90% due to the viral infection.Upper respiratory tract infection also can feed through to adjacent organs or spread downwards, causes otitis media, nasosinustis, dacryocystisis, retropharyngeal abscess, cervical lymphadenitis, laryngitis, tracheitis, bronchitis, pneumonia etc.Wherein concurrent otitis media can cause permanent auditory dysesthesia.Pneumonia but is one of high reason of developing country's child mortality.Older youngster can cause diseases such as acute nephritis, rheumatic fever if suffer from streptococcus property upper respiratory tract infection.
Acute upper respiratory tract infection belongs to traditional Chinese medical science infantile common cold, and the sickness rate in the child is higher, assembles at collective childrens such as nursery school, kindergarten, primary schools particularly that ground is the easiest to cause cross infection.At present the prevention of feeling on the collective children is mainly run into following point both at home and abroad:
1. inject gamma globulin and can not reduce upward sense sickness rate effectively;
2. use the drug price costliness of raise immunity, be difficult to promote;
3. adopt furacillin solution or berberine aqueous solution spray larynx, its bitter in the mouth can't be comply with the child;
Though 4. adopt vinegar spray larynx that preventive effect is arranged, acidity is too strong, life-time service easily causes the teenager teeth decalcification, and enamel is impaired, and reduces the resistance of cariogenic bacteria, thereby brings out dental caries.In addition, vinegar also easily causes dentin hypersensitiveness and produces pain, and unfavorable to the gastrointestinal protection.
In the prior art,, be specifically designed to the prevention childhood upper respiratory tract infection, especially prevent the Chinese patent medicine of collective children upper respiratory tract infection actually rare though the Chinese medicinal formulae of multiple prevention upper respiratory tract infection is arranged.Therefore, be necessary prior art is improved.
Summary of the invention
The object of the present invention is to provide a kind ofly have heat-clearing and toxic substances removing, the consolidating superficial resistance that dispels the wind, safe and practical, and can effectively reduce the Chinese medicine preparation that the child goes up the sense sickness rate.
Technical scheme of the present invention is based on the theory of the traditional Chinese medical science to infantile common cold, and promptly infantile common cold is because of experiencing due to the ailment said due to cold or exposure, and, pharyngalgia red with heating, pharynx, watery nasal discharge, cough are cardinal symptom, and see that with heat symptom-complex sympotoms caused by cold factors are less more, and diseased region is mainly in pulmonary.And throat is the door of lung, when running into external ailment said due to cold or exposure, stands in the breach and will be encroached on.For preventing infantile common cold, at first the heresy of affection due to external wind and heat should be refused outside it " door ".Therefore, adopt the pure natural plant medicine of heat-clearing and toxic substances removing, the consolidating superficial resistance that dispels the wind, and,, have the effect of the wind heat of resisting the invasion oral cavity through the medicine that scientific formula is made according to theory of Chinese medical science.
The present invention's medicine is made (consumption is a weight portion) by following component:
Flos Lonicerae 8-25 Fructus Forsythiae 8-25
Radix Isatidis 8-20 Radix Platycodonis 10-20
Rhizoma Osmundae 8-20 Radix Saposhnikoviae 8-20
Fructus Arctii 8-25 Rhizoma Belamcandae 6-15
Herba Menthae 3-12 Radix Glycyrrhizae 3-12.
Adopt existing medicine process technology, above-mentioned each component is made the Chinese medicine throat spray.
Described component contains multiple anti-cold virus, rhinovirus, adenovirus, anti-microbial pathogen, and antiinflammatory, analgesic, the active drug composition of enhancing body resistance makes it to have heat-clearing and toxic substances removing, the effect of the consolidating superficial resistance that dispels the wind.Especially the chlorogenic acid in the Flos Lonicerae, Rhizoma Iridis Tectori glycoside in the Rhizoma Belamcandae and glycoside unit thereof etc. are antiviral, antibiotic, antiinflammatory, analgesic and improve the effective ingredient of body's immunity.Chlorogenic acid in the ingredient can also be killed cariogenic bacteria in addition.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the present invention is a raw material with the pure natural plant medicine all, and each constituent mass standard all meets the regulation of Chinese Pharmacopoeia, no chemical addition agent.
2, the present invention confirms that through pharmacological evaluation the maximum tolerated dose (MTD) of its white mice per os acute toxicity testing is 2435 times that the child is sprayed larynx consumption (1ml/ time), and it is safe.
3, dosage of the present invention is little, the taste sweetness, and children compliance height, economical and practical.
4, the present invention specially at Susceptible population promptly hold in the palm, young garden, collective children such as primary school and developing sprays usefulness before the child goes into garden, entrance every day, can play preventive effect preferably.
Be the Vaxigrip that the shows the present invention effect to preventing cold, the present invention is through the clinical observation of routine systems up to a hundred, and its effect is as follows:
The object of observation: the child who chooses kindergarten 3-6 year carries out random packet.Wherein 200 examples are organized in prevention, male 101 examples, women 99 examples, 4.6 years old mean age, 17.7 kilograms of average weights; Matched group 178 examples, male 88 examples, women 90 examples, 4.5 years old mean age, 17.5 kilograms of average weights.Two groups of men, women ratio, age, body weight are learned processing by statistics, no significant difference.
Method and observation index: two groups of children, go into garden and noon per morning and carry out twice inspection by the special messenger, to suffering from acute respiratory infection symptom and sign person, build the volume registration, after the inspection in morning, the prevention group is sprayed larynx with the present invention's Vaxigrip, sprays 1ml at every turn; Matched group sprays larynx with 50% vinegar, each 2ml, and spray once every day.The diagnosis of acute respiratory infection is divided into: swallow red, antiadoncus, snivel, cough generate heat five, individual ill person-time of one or a few Xiang Weiyi occur wherein.Two groups of administrations simultaneously after 80 days, observed data is gathered and carry out statistical procedures, two groups of total prevalence rates relatively see Table 1; Two groups of prevalences observe first, fourth bimester relatively see Table 2; The each age group prevalence relatively saw Table 3 before and after the prevention group was observed; Two groups the heating person-time and ill person-time relatively see Table 4.
Table 2 is observed first, fourth month prevalence relatively
The each age group prevalence relatively before and after table 3 prevention group was observed
| First month April |
| Observe the ill group of ill observation person-time person-time rate (%) person-time person-time rate (%) |
| 3,687 976 26.47 3,712 332 8.94 matched groups, 3,344 915 27.36 3,342 377 11.28 P＞0.01＜0.01 are organized in prevention |
| After observing before observing |
| Age bracket is observed the ill P value of ill observation people rate (%) the people rate (%) that tells noses that tells noses |
| 3 years old 29 9 31.03 30 00＜0.01 4 years old 84 17 20.24 81 1 1.23＜0.01 5～6 years old 80 16 20 67 3 4.48＜0.01 |
Table 1 total prevalence rate comparison sheet 4 heating person-time and ill person-time of comparison
| Group is observed person-time ill person-time of prevalence (%) |
| 14,372 2,237 15.56 matched groups, 13,133 2,206 16.80 P＜0.01 are organized in prevention |
| Ill person-time of heating of group person-time percentage ratio (%) |
| 2,237 32 1.43 matched groups, 2,206 56 2.54 P＜0.01 are organized in prevention |
The result shows: Vaxigrip and vinegar preventive effect have significant difference (P＜0.01), and Vaxigrip obviously is better than vinegar (seeing Table 1,2).Table 2 shows that also along with the prolongation of administration time, both difference is obvious more.Table 3 shows that before and after the medication of prevention group, the each age group prevalence all has significant difference, this dosage for off year the age group child more suitable, its effect is best.Table 4 shows that Vaxigrip has positive effect to the control of acute respiratory infection heating paresthesia.
The specific embodiment
Embodiment 1
Take by weighing raw material (kilogram) by following proportioning, and adopt existing process technology to make throat spray:
Flos Lonicerae 12 Fructus Forsythiaes 12
Radix Isatidis 15 Radix Platycodoniss 10
Rhizoma Osmundae 15 Radix Saposhnikoviaes 10
Fructus Arctii 8 Rhizoma Belamcandae 6
Herba Menthae 3 Radix Glycyrrhizaes 3.
Embodiment 2
Take by weighing raw material (kilogram) by following proportioning, and adopt existing process technology to make throat spray:
Flos Lonicerae 25 Fructus Forsythiaes 20
Radix Isatidis 20 Radix Platycodoniss 20
Rhizoma Osmundae 20 Radix Saposhnikoviaes 20
Fructus Arctii 25 Rhizoma Belamcandae 8
Herba Menthae 12 Radix Glycyrrhizaes 12.
Embodiment 3
Take by weighing raw material (kilogram) by following proportioning, and adopt existing process technology to make throat spray:
Flos Lonicerae 15 Fructus Forsythiaes 16
Radix Isatidis 12 Radix Platycodoniss 15
Rhizoma Osmundae 14 Radix Saposhnikoviaes 14
Fructus Arctii 18 Rhizoma Belamcandae 10
Herba Menthae 6 Radix Glycyrrhizaes 8.
Embodiment 4
Take by weighing raw material (kilogram) by following proportioning, and adopt existing process technology to make throat spray:
Flos Lonicerae 20 Fructus Forsythiaes 10
Radix Isatidis 10 Radix Platycodoniss 10
Rhizoma Osmundae 18 Radix Saposhnikoviaes 20
Fructus Arctii 20 Rhizoma Belamcandae 12
Herba Menthae 5 Radix Glycyrrhizaes 7.
Claims (1)
1, a kind of throat spray that prevents acute upper respiratory tract infection of children group is characterized in that it is made by following materials of weight proportions:
Flos Lonicerae 8-25 Fructus Forsythiae 8-25
Radix Isatidis 8-20 Radix Platycodonis 10-20
Rhizoma Osmundae 8-20 Radix Saposhnikoviae 8-20
Fructus Arctii 8-25 Rhizoma Belamcandae 6-15
Herba Menthae 3-12 Radix Glycyrrhizae 3-12.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011289600A CN1172696C (en) | 2001-10-13 | 2001-10-13 | Medicine for preventing acute upper respiratory tract infection of children group |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011289600A CN1172696C (en) | 2001-10-13 | 2001-10-13 | Medicine for preventing acute upper respiratory tract infection of children group |
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| Publication Number | Publication Date |
|---|---|
| CN1411828A CN1411828A (en) | 2003-04-23 |
| CN1172696C true CN1172696C (en) | 2004-10-27 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011289600A Expired - Fee Related CN1172696C (en) | 2001-10-13 | 2001-10-13 | Medicine for preventing acute upper respiratory tract infection of children group |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102000224B (en) * | 2010-11-22 | 2012-04-25 | 云南中医学院 | Preparation method of medicine for preventing and treating acute upper respiratory tract infection |
| CN102258674B (en) * | 2011-07-25 | 2013-02-27 | 李燕 | Traditional Chinese medicine composition for treating children upper respiratory tract infection |
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