CN117229906A - Nucleic acid amplification device - Google Patents
Nucleic acid amplification device Download PDFInfo
- Publication number
- CN117229906A CN117229906A CN202311175748.0A CN202311175748A CN117229906A CN 117229906 A CN117229906 A CN 117229906A CN 202311175748 A CN202311175748 A CN 202311175748A CN 117229906 A CN117229906 A CN 117229906A
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- Prior art keywords
- tube
- amplification
- tube seat
- nucleic acid
- connecting rod
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- 230000003321 amplification Effects 0.000 title claims abstract description 89
- 238000003199 nucleic acid amplification method Methods 0.000 title claims abstract description 89
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 29
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 29
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 29
- 238000010438 heat treatment Methods 0.000 claims abstract description 25
- 230000003287 optical effect Effects 0.000 claims abstract description 23
- 230000005540 biological transmission Effects 0.000 claims description 16
- 238000003752 polymerase chain reaction Methods 0.000 description 22
- 238000000034 method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
Abstract
The invention discloses a nucleic acid amplification device, which belongs to the field of medical appliances, wherein an optical cover plate is fixed on a support frame; the tube seat assembly is slidably mounted on the support frame, and the tube seat driving structure drives the tube seat assembly to move along a first direction; the mounting seat is arranged on the amplification driving structure, the temperature control assembly is arranged in the mounting seat, the upper cover is arranged on the mounting seat, the amplification driving structure drives the amplification structure to move along the second direction perpendicular to the first direction, so that the heating seat is close to or far away from the PCR tube on the tube seat assembly.
Description
Technical Field
The present invention relates to the field of medical devices, and in particular to a nucleic acid amplification device.
Background
The nucleic acid amplification device is an instrument for amplifying a specific DNA by using a PCR (Polymerase chain reaction ) technique, and is widely used in medical and biological laboratories, for example, for determining whether a genetic disease is present in a sample, for diagnosing an infectious disease, for gene replication, for paternity test, and the like.
At present, most of the mainstream nucleic acid amplification devices need to manually switch a bin gate or realize the switching action of the bin gate through a motion mechanism when placing PCR tubes. In the process of opening the bin gate, the whole heating seat and related components are exposed outside the device, the exposed part has larger volume, and the heating seat is easily influenced by external environment. In addition, in the process of placing the PCR tube, the heating seat and related components also need to be moved out of the bin, and the driving force of the driving structure is required to be large, so that the driving structure is large in size.
Disclosure of Invention
In order to overcome the defects of the prior art, one of the purposes of the invention is to provide a nucleic acid amplification device which reduces the influence of the external environment on a heating seat in the process of placing a PCR tube, has small driving force of a driving structure and has small whole volume.
One of the purposes of the invention is realized by adopting the following technical scheme:
the nucleic acid amplification device comprises a support frame, an optical cover plate, a tube seat assembly, a tube seat driving structure, an amplification structure and an amplification driving structure,
the optical cover plate is fixed on the supporting frame;
the tube seat assembly is slidably mounted on the support frame, and the tube seat driving structure is in transmission connection with the tube seat assembly and drives the tube seat assembly to move along a first direction so as to extend out of the bottom of the optical cover plate to mount the PCR tube;
the amplification structure is located the tube holder subassembly bottom makes the tube holder subassembly is located the optics apron and between the amplification structure, the amplification structure includes mount pad, temperature control subassembly and upper cover, temperature control subassembly includes the heating seat, the mount pad install in the amplification drive structure, temperature control subassembly is located in the mount pad, the upper cover install in the mount pad, the drive of amplification drive structure drive the amplification structure is along perpendicular to the second direction of first direction removes, makes the heating seat is close to PCR tube control PCR tube temperature on the tube holder subassembly or keep away from PCR tube on the tube holder subassembly is convenient for the tube holder subassembly removes in first direction.
Further, the amplification driving structure is positioned at the bottom of the amplification structure.
Further, the support frame includes bottom plate, stand and crossbeam, the stand both ends respectively with the bottom plate with the crossbeam is fixed, the crossbeam with the bottom plate is parallel, the optics apron is fixed in the crossbeam, tube socket subassembly slidable mounting in the crossbeam is located optics apron bottom, the expansion drive structure is fixed in the bottom plate, the expansion structure is located tube socket subassembly bottom.
Further, the tube seat driving structure comprises a tube seat driving piece and a transmission piece, wherein the tube seat driving piece is fixed on the cross beam, the output end of the tube seat driving piece is connected with the transmission piece, and the transmission piece drives the tube seat assembly to move in a first direction.
Further, the tube seat driving piece is a motor, the transmission piece is a belt, the tube seat driving structure further comprises a connecting block, the belt is sleeved at the output end of the motor, the connecting block is fixed on the belt, and the connecting block is fixedly connected with the tube seat assembly.
Further, the tube seat assembly comprises two connecting plates and a tube seat main body, wherein two sides of the tube seat main body are respectively connected with the two connecting plates, the number of the cross beams is two, the two cross beams are parallel to each other, each connecting plate is in sliding connection with one cross beam, and the tube seat main body is provided with a plurality of mounting holes for mounting the PCR tubes.
Further, the tube seat assembly further comprises a first baffle and a first optocoupler, wherein the first baffle is fixed on the connecting plate, the first optocoupler is fixed on the cross beam, and the first baffle stretches into the first optocoupler when moving along with the connecting plate so as to detect the position of the tube seat assembly.
Further, the amplification driving structure comprises an amplification driving piece, a first connecting rod, a second connecting rod, a first guide rail fixing block and a second guide rail fixing block, the amplification driving piece is fixed on the bottom plate, the second guide rail fixing block is slidably mounted on the bottom plate, the output end of the amplification driving piece is connected with the second guide rail fixing block, the amplification driving piece drives the second guide rail fixing block to slide relative to the bottom plate, one end of the first connecting rod is rotationally connected with the second guide rail fixing block, the other end of the first connecting rod is rotationally connected with the mounting seat, one end of the second connecting rod is rotationally connected with the bottom plate, the other end of the second connecting rod is rotationally connected with the first guide rail fixing block, the first guide rail fixing block is in sliding connection with the mounting seat, and the first connecting rod is rotationally connected with the second connecting rod.
Further, the first connecting rod and the second connecting rod form an X shape.
Further, the first connecting rod and the second connecting rod are both H-shaped.
Compared with the prior art, the optical cover plate of the nucleic acid amplification device is fixed on the supporting frame; the tube seat assembly is slidably mounted on the support frame, and the tube seat driving structure is in transmission connection with the tube seat assembly and drives the tube seat assembly to move along a first direction so as to extend out of the bottom of the optical cover plate for mounting the PCR tube; the amplification structure is arranged at the bottom of the tube seat assembly to enable the tube seat assembly to be arranged between the optical cover plate and the amplification structure, the amplification structure comprises a mounting seat, a temperature control assembly and an upper cover, the temperature control assembly comprises a heating seat, the mounting seat is arranged on the amplification driving structure, the temperature control assembly is arranged in the mounting seat, the upper cover is arranged on the mounting seat, the amplification driving structure drives the amplification structure to move along a second direction perpendicular to the first direction, so that the heating seat is close to the PCR tube on the tube seat assembly to control the temperature of the PCR tube or far away from the PCR tube on the tube seat assembly to facilitate the movement of the tube seat assembly in the first direction.
Drawings
FIG. 1 is a perspective view of a nucleic acid amplification apparatus of the present invention;
FIG. 2 is a perspective view of an optical cover plate of the nucleic acid amplification apparatus of FIG. 1;
FIG. 3 is a partial perspective view of the nucleic acid amplification apparatus of FIG. 1;
FIG. 4 is a perspective view of another partial structure of the nucleic acid amplification apparatus of FIG. 1;
FIG. 5 is a perspective view of an amplification structure of the nucleic acid amplification apparatus of FIG. 4;
FIG. 6 is a perspective view of a temperature control assembly of the amplification structure of FIG. 5;
FIG. 7 is a perspective view of the mount of the amplification structure of FIG. 5;
FIG. 8 is a perspective view of an amplification driving structure of the nucleic acid amplification apparatus of FIG. 4;
FIG. 9 is a perspective view showing a further partial structure of the nucleic acid amplification apparatus of FIG. 1.
In the figure: 10. a support frame; 11. a bottom plate; 110. a plate body; 111. supporting feet; 12. a column; 13. a cross beam; 20. an optical cover plate; 21. a cover plate main body; 22. a connecting column; 23. a heat insulating plate; 24. heating the film; 25. a thermal cover; 250. a body; 251. a side edge; 30. a header assembly; 31. a connecting plate; 32. a stem body; 320. a mounting hole; 40. a tube seat driving structure; 41. a stem driver; 42. a transmission member; 43. a connecting block; 44. a first slide rail; 45. a first slider; 46. a first baffle; 47. a first optocoupler; 50. an amplification structure; 51. a mounting base; 510. a base; 5101. a fixing plate; 5102. a side plate; 5103. an opening; 511. an elastic member; 512. a fan; 513. a stop block; 514. a second baffle; 52. a temperature control assembly; 520. a heating seat; 521. a heat sink; 522. an insulating plate; 523. a positioning pin; 524. a fixing member; 525. a cooling sheet; 53. an upper cover; 60. an amplification driving structure; 61. an amplification driving member; 62. a mounting block; 63. a first link; 64. a second link; 65. a first rail fixing block; 66. a guide rail; 67. a second rail fixing block; 68. a third baffle; 69. and a third optocoupler.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It will be understood that when an element is referred to as being "fixed to" another element, it can be directly on the other element or be present as another intermediate element through which the element is fixed. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When an element is referred to as being "disposed on" another element, it can be directly on the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like are used herein for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.
As shown in FIGS. 1 to 9, the nucleic acid amplification apparatus of the present invention comprises a support frame 10, an optical cover plate 20, a stem assembly 30, a stem driving structure 40, an amplification structure 50, and an amplification driving structure 60.
The support frame 10 includes a base plate 11, uprights 12, and cross members 13. The base plate 11 includes a plate body 110 and a plurality of support legs 111 mounted to the bottom of the plate body 110. The column 12 is fixed to the plate body 110 and is perpendicular to the plate body 110. Specifically, the number of the columns 12 is four, and the four columns 12 are located at four corners of the plate 110. The cross beam 13 is fixed to the top end of the upright 12. Specifically, the number of the cross beams 13 is two, and the two cross beams 13 are parallel to each other.
The optical cover 20 includes a cover body 21, a connection post 22, a heat insulating plate 23, a heating film 24, and a heat cover 25. The cover main body 21 is fixed to the cross beams 13 through the connection posts 22, and the cover main body 21 is positioned between the two cross beams 13 and parallel to the plate body 110. The heat insulating plate 23 is mounted to the cover main body 21 on the side facing the plate body 110. The heating film 24 is mounted to the heat cover 25. The thermal cover 25 includes a body 250 and sides 251 extending from the edges of the body 250, the sides 251 being located on three sides of the body 250, the sides 251 being capable of abutting against the edges of the header body 32 so that the header body 32 can move in only one direction relative to the optical cover 20.
The header assembly 30 includes two connection plates 31 and a header body 32 positioned between the connection plates 31. Both sides of the tube seat main body 32 are respectively connected with the two connecting plates 31, so that the connecting plates 31 can drive the tube seat main body 32. The connection plate 31 is slidably connected to the cross member 13, and the socket main body 32 is provided with a mounting hole 320, and the mounting hole 320 is used for mounting the PCR tube.
The socket driving structure 40 includes a socket driving member 41, a transmission member 42, a connection block 43, a first slide rail 44, a first slider 45, a first blocking piece 46, and a first optocoupler 47. The socket driving member 41 is fixed to the cross member 13. In the present embodiment, the socket driving member 41 is a motor. The transmission member 42 is connected to the socket driving member 41 to move the socket assembly 30. In this embodiment, the transmission member 42 is a belt. The transmission member 42 is sleeved on the output end of the tube seat driving member 41 and the roller, and the roller is rotatably mounted on the cross beam 13. The connection block 43 is fixed to the belt and the connection block 43 is fixed to the connection plate 31. The first sliding block 45 is fixed at the bottom of the connecting plate 31, the first sliding rail 44 is fixed at the cross beam 13, and the connecting plate 31 is slidably mounted at the cross beam 13 by matching the first sliding block 45 with the first sliding rail 44. The first slide rail 44 extends in a first direction parallel to the plate body 110. The first blocking piece 46 is fixed on the connecting plate 31, the first optical coupler 47 is fixed on the cross beam 13, and an electric signal is generated when the first blocking piece 46 passes through the first optical coupler 47, so that the position of the tube seat assembly 30 is detected.
The amplification structure 50 includes a mounting block 51, a temperature control assembly 52, and a top cover 53.
The mounting seat 51 is used for accommodating the temperature control component 52, so as to prevent the temperature control component 52 from being influenced by external environment. The mounting base 51 includes a base 510, an elastic member 511, a fan 512, a stopper 513, a second baffle 514, and a second optocoupler. The base 510 includes a fixing plate 5101 and four side plates 5102. The four side plates 5102 are fixed to the fixing plate 5101, and the fixing plate 5101 and the four side plates 5102 form an accommodating space. Openings 5103 are provided in the opposite side plates 5102, and the openings 5103 are used for heat dissipation. The fan 512 is fixed on the surface of the fixing plate 5101, the elastic member 511 is mounted on the fixing plate 5101, and the elastic member 511 is used for carrying the temperature control assembly 52. Specifically, the number of the elastic members 511 is plural, and the plurality of elastic members 511 are distributed at four corners of the fan 512. A stopper 513 is fixed to an edge of the fixing plate 5101, and the stopper 513 serves to prevent the first rail fixing block 65 from being separated from the rail 66. The second baffle 514 is fixed on the base 510, the second optocoupler is fixed on the upright 12, and when the amplifying structure 50 moves up and down to the limit position, the second baffle 514 passes through the second optocoupler to generate an electrical signal, so as to ensure that the amplifying structure 50 moves in place.
The temperature control assembly 52 includes a heating seat 520, a heat sink 521, an insulating plate 522, a positioning pin 523, a fixing member 524, and a cooling fin 525. The heat sink 521 is fixed to the heating base 520 by a fixing member 524. The cooling fin 525 is located between the heating seat 520 and the heat sink 521, and controls the temperature of the heating seat 520. An insulating plate 522 is attached to the upper end surface of the heat sink 521, and a positioning pin 523 is fixed to the heat sink 521. The temperature control unit 52 is accommodated in the mount 51.
The upper cover 53 is mounted to the mount 51 and covers the temperature control assembly 52. The upper cover 53 is provided with a through groove, and the position of the through groove is opposite to the heating seat 520, so that the PCR tube can conveniently extend into the heating seat 520 for heating.
The amplification driving structure 60 includes an amplification driving part 61, a mounting block 62, a first link 63, a second link 64, a first rail fixing block 65, a rail 66, a second rail fixing block 67, a third shutter 68, and a third optocoupler 69. The amplification driving part 61 is fixed to the base plate 11 by a mounting block 62. In the present embodiment, the amplification driving part 61 is a linear motor. The guide rail 66 is fixed on the bottom plate 11, the second guide rail fixing block 67 is slidably mounted on the guide rail 66, and the output end of the amplification driving member 61 is connected with the second guide rail fixing block 67 to drive the second guide rail fixing block 67 to slide relative to the bottom plate 11. The first connecting rod 63 is H-shaped, one end of the first connecting rod 63 is rotationally connected with the second guide rail fixing block 67, and the other end of the first connecting rod 63 is rotationally connected with the mounting seat 51. One end of the second connecting rod 64 is rotatably connected with the bottom plate 11, the middle part is rotatably connected with the first connecting rod 63, and the other end is rotatably connected with the first guide rail fixing block 65. The first rail fixing block 65 is slidably mounted to the mount 51 via a rail 66. An X-shaped structure is formed between the first link 63 and the second link 64.
When the nucleic acid amplification device is used, the amplification driving structure 60 drives the amplification structure 50 to move (move downwards) along a second direction perpendicular to the first direction, the tube seat driving structure 40 drives the tube seat assembly 30 to move (move transversely) along the first direction, at this time, the tube seat assembly 30 moves out from the position below the optical cover plate 20, the PCR tube is mounted to the mounting hole 320 of the tube seat assembly 30, the tube seat driving structure 40 drives the tube seat assembly 30 to reset, the amplification driving structure 60 drives the amplification structure 50 to move upwards until the positioning pin 523 stretches into the positioning hole of the optical cover plate 20, the heat cover 25 is abutted against the upper end of the PCR tube, the bottom of the PCR tube is positioned in the taper hole of the heating seat 520, the second baffle 514 of the amplification structure 50 moves to the position of the second optical coupler, the PCR tube is compressed, and the temperature control assembly 52 controls the temperature of the PCR tube to realize amplification. Through the design, in the whole PCR tube placement process, the heating seat 520 is not exposed from the upper cover 53, so that the influence of the external environment on the heating seat 520 is reduced, the whole weight of the tube seat assembly 30 is small, the power requirement for driving the tube seat driving structure 40 of the tube seat assembly 30 is low, the volume of the tube seat driving structure 40 is small, the weight is light, and the volume of the nucleic acid amplification device is reduced.
The foregoing examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that, for those skilled in the art, it is possible to make several modifications and improvements without departing from the concept of the present invention, which are equivalent to the above embodiments according to the essential technology of the present invention, and these are all included in the protection scope of the present invention.
Claims (10)
1. Nucleic acid amplification device, including the support frame, its characterized in that: also comprises an optical cover plate, a tube seat assembly, a tube seat driving structure, an amplifying structure and an amplifying driving structure,
the optical cover plate is fixed on the supporting frame;
the tube seat assembly is slidably mounted on the support frame, and the tube seat driving structure is in transmission connection with the tube seat assembly and drives the tube seat assembly to move along a first direction so as to extend out of the bottom of the optical cover plate to mount the PCR tube;
the amplification structure is located the tube holder subassembly bottom makes the tube holder subassembly is located the optics apron and between the amplification structure, the amplification structure includes mount pad, temperature control subassembly and upper cover, temperature control subassembly includes the heating seat, the mount pad install in the amplification drive structure, temperature control subassembly is located in the mount pad, the upper cover install in the mount pad, the drive of amplification drive structure drive the amplification structure is along perpendicular to the second direction of first direction removes, makes the heating seat is close to PCR tube control PCR tube temperature on the tube holder subassembly or keep away from PCR tube on the tube holder subassembly is convenient for the tube holder subassembly removes in first direction.
2. The nucleic acid amplification apparatus according to claim 1, wherein: the amplification driving structure is positioned at the bottom of the amplification structure.
3. The nucleic acid amplification apparatus according to claim 1, wherein: the support frame includes bottom plate, stand and crossbeam, the stand both ends respectively with the bottom plate with the crossbeam is fixed, the crossbeam with the bottom plate is parallel, the optics apron is fixed in the crossbeam, tube socket subassembly slidable mounting in the crossbeam is located optics apron bottom, the amplification drive structure is fixed in the bottom plate, the amplification structure is located tube socket subassembly bottom.
4. The nucleic acid amplification apparatus according to claim 3, wherein: the tube seat driving structure comprises a tube seat driving piece and a transmission piece, wherein the tube seat driving piece is fixed on the cross beam, the output end of the tube seat driving piece is connected with the transmission piece, and the transmission piece drives the tube seat assembly to move in a first direction.
5. The nucleic acid amplification apparatus according to claim 4, wherein: the pipe seat driving piece is a motor, the transmission piece is a belt, the pipe seat driving structure further comprises a connecting block, the belt is sleeved at the output end of the motor, the connecting block is fixed on the belt, and the connecting block is fixedly connected with the pipe seat assembly.
6. The nucleic acid amplification apparatus according to claim 5, wherein: the tube seat assembly comprises two connecting plates and a tube seat main body, wherein two sides of the tube seat main body are respectively connected with the two connecting plates, the number of the cross beams is two, the two cross beams are parallel to each other, each connecting plate is in sliding connection with one cross beam, and the tube seat main body is provided with a plurality of mounting holes for mounting the PCR tubes.
7. The nucleic acid amplification apparatus according to claim 6, wherein: the tube seat assembly further comprises a first baffle and a first optical coupler, the first baffle is fixed on the connecting plate, the first optical coupler is fixed on the cross beam, and the first baffle stretches into the first optical coupler to detect the position of the tube seat assembly when moving along with the connecting plate.
8. The nucleic acid amplification apparatus according to claim 3, wherein: the amplification driving structure comprises an amplification driving piece, a first connecting rod, a second connecting rod, a first guide rail fixing block and a second guide rail fixing block, wherein the amplification driving piece is fixed on the bottom plate, the second guide rail fixing block is slidably mounted on the bottom plate, the output end of the amplification driving piece is connected with the second guide rail fixing block, the amplification driving piece drives the second guide rail fixing block to slide relative to the bottom plate, one end of the first connecting rod is rotationally connected with the second guide rail fixing block, the other end of the first connecting rod is rotationally connected with the mounting seat, one end of the second connecting rod is rotationally connected with the bottom plate, the other end of the second connecting rod is rotationally connected with the first guide rail fixing block, the first guide rail fixing block is in sliding connection with the mounting seat, and the first connecting rod is rotationally connected with the second connecting rod.
9. The nucleic acid amplification apparatus according to claim 8, wherein: the first connecting rod and the second connecting rod form an X shape.
10. The nucleic acid amplification apparatus according to claim 8, wherein: the first connecting rod and the second connecting rod are all H-shaped.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311175748.0A CN117229906A (en) | 2023-09-11 | 2023-09-11 | Nucleic acid amplification device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311175748.0A CN117229906A (en) | 2023-09-11 | 2023-09-11 | Nucleic acid amplification device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117229906A true CN117229906A (en) | 2023-12-15 |
Family
ID=89087268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311175748.0A Pending CN117229906A (en) | 2023-09-11 | 2023-09-11 | Nucleic acid amplification device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117229906A (en) |
-
2023
- 2023-09-11 CN CN202311175748.0A patent/CN117229906A/en active Pending
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