CN117159614A - Traditional Chinese medicine composition for treating ankylosing spondylitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating ankylosing spondylitis and preparation method thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The application discloses a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The application discloses a traditional Chinese medicine composition for treating ankylosing spondylitis, which comprises the following raw materials in parts by weight: 30-50 parts of cassia twig, 10-20 parts of fructus psoraleae, 10-20 parts of diverse wormwood herb, 15-60 parts of cowherb seed, 30-50 parts of evening primrose, 40-60 parts of rhizoma cibotii, 5-15 parts of eucommia ulmoides, 1-10 parts of philippine flemingia root, 10-30 parts of plantain herb and 1-10 parts of beautiful millettia root. The traditional Chinese medicine composition has the advantages of convenient use, rapid curative effect, high cure rate and lasting effect.
Description
Technical Field
The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof.
Background
Ankylosing Spondylitis (AS) is a disease with inflammation of the sacroiliac joint and spinal attachment points AS the main symptoms. Has strong association with HLA-B27. Some microorganisms (e.g., klebsiella) have common antigens with the tissues of the susceptible individual themselves, which can elicit an aberrant immune response. Is a chronic inflammatory disease characterized by the large joints of limbs, fibrosis and ossification of the fibrous annulus of the intervertebral disc and connective tissues nearby, and joint rigidity. Ankylosing spondylitis belongs to the category of rheumatism, and causes are not clear, and is a chronic disease taking a spine as a main lesion part, involves sacroiliac joints, causes spine ankylosis and fibrosis, causes eye, lung, muscle and skeleton lesions of different degrees, and is an autoimmune disease.
In the field of traditional Chinese medicine, AS has the characteristics of complexity and difficult treatment, besides the symptoms of various medial axis joints, the AS also has joint appearance, and joint stiffness and deformity are serious. The basic pathogenesis of the disease is based on kidney deficiency and governor vessel, and exogenous six-pathogenic factors and traumatic evil are used as the principal. "Su Wen-Sheng Qi Tong Tian Lun" means: the yang qi is effective in nourishing spirit, and softening tendons, and has the effects of nourishing, warming and protecting skin, muscle, vein and bone joints, so as to relieve damage and joint deformation of skin, muscle, vein and bone joints. The term "clinical diagnosis and treatment of traditional Chinese medicine" was named "spinal arthralgia" in 1997 and is explained as follows: pain in the lumbar spine, and even more, can be manifested as deformity of the spine, and limited function of strengthening; or severe pain with back muscle, tiredness or severe overcast and rainy weather symptoms. Jiao Shude the term "Dakets" in "Su-Sheng Qi Tong Tian Lun" refers to serious disease, ankylosing and humpback deformity, so it is discussed that the arthralgia of the spine is classified as "Dakets" in traditional Chinese medicine.
Modern researches have shown that the traditional Chinese medicine has definite curative effect on ankylosing spondylitis, can reduce the acute-phase inflammation index, remarkably improve the spinal pain, BASDAI, BASF, finger-ground distance, occipital wall distance and thoracic cavity mobility of patients, has higher safety and is superior to the single western medicine treatment.
The traditional Chinese medicine has 1) needling therapy for AS treatment, and has the characteristics of unexpected curative effect and high safety when being used for treating the axial type spinal arthropathy by adopting common needling, and the acupuncture can achieve the purposes of dredging channels and collaterals, harmonizing yin and yang, strengthening vital qi to eliminate evil, running qi and blood and preventing and treating diseases. 2) Moxibustion therapy Ai Jiuyou has the effects of strengthening body resistance and restoring yang, warming channels and dispelling cold, and promoting qi circulation and dredging collaterals, and is very suitable for deficiency-cold syndrome. There are studies showing that: moxibustion has effects of activating yang qi, warming yang and dispelling cold. 3) Moxibustion, medicine and needle combination methods are adopted by people in the prior art to treat ankylosing spondylitis in the active period by combining bee needles with celecoxib, and bee venom and chelation are used for stimulating channels and collaterals and acupoints to perform one of three effects of moxibustion, medicine and needle, so that the effects of warming and dredging channels and collaterals, relieving swelling and pain, removing blood stasis and activating blood circulation, eliminating evil and strengthening body resistance can be achieved for the treatment of arthralgia. In the above-mentioned therapies, doctors are required to have very specialized skills, but most doctors prescribe medicines, and do not have specialized skills such as needling or moxibustion, so that patients cannot be truly treated.
The prior art also discloses a plaster for treating ankylosing spondylitis, named as ling xian snake-scorpion plaster, but the plaster has complex components, contains radix clematidis, zaocys dhumnade, scorpion, radix aconiti kusnezoffii, nux vomica, notopterygium root, radix angelicae pubescentis, rhizoma drynariae, garden balsam stem, ground beetle, centipede, olibanum, myrrh, aconite, tripterygium wilfordii, glabrous greenbrier rhizome, rhizoma corydalis, white mustard seed, eucommia bark, rhizoma cibotii, aconite root, deer horn gum, caulis sinomenii, yellow lead, perfume and the like, wherein the components such as the aconite root and the garden balsam stem are toxic; radix Clematidis with small toxicity; plumbum Preparatium, pungent and slightly cold, is toxic. The raw material medicines required in the existing researches and technologies for treating rheumatic diseases often have the defects of difficult acquisition, narrow source range, high consumption cost, complex formula, large preparation process difficulty, long treatment period, slow effect, large risk (toxic) and the like.
Disclosure of Invention
The application provides a traditional Chinese medicine composition for treating ankylosing spondylitis and a preparation method thereof, which are used for solving the technical problems of high treatment cost, side effects and the like in the prior art, and has good curative effect on orthopedic diseases, especially ankylosing spondylitis, long-term effective treatment effect, no toxic or side effects, and simultaneously has the effects of promoting qi and blood regulation of a human body, ensuring smooth channels and collaterals, and avoiding the need of acupuncture and moxibustion skills, and is convenient to use.
In a first aspect, the application provides a traditional Chinese medicine composition for treating ankylosing spondylitis, which comprises the following raw materials in parts by weight:
30-50 parts of cassia twig, 10-20 parts of fructus psoraleae, 10-20 parts of diverse wormwood herb, 15-60 parts of cowherb seed, 30-50 parts of evening primrose, 40-60 parts of rhizoma cibotii, 5-15 parts of eucommia ulmoides, 1-10 parts of philippine flemingia root, 10-30 parts of plantain herb and 1-10 parts of beautiful millettia root.
Preferably, the material comprises the following raw materials in parts by weight:
30-40 parts of cassia twig, 10-15 parts of fructus psoraleae, 15-20 parts of diverse wormwood herb, 15-30 parts of cowherb seed, 45-50 parts of evening primrose, 45-50 parts of rhizoma cibotii, 5-10 parts of eucommia ulmoides, 1-5 parts of philippine flemingia root, 10-20 parts of plantain herb and 1-5 parts of beautiful millettia root.
Preferably, the material comprises the following raw materials in parts by weight:
35 parts of cassia twig, 12 parts of fructus psoraleae, 18 parts of diverse wormwood herb, 30 parts of cowherb seed, 50 parts of evening primrose, 45 parts of rhizoma cibotii, 8 parts of eucommia ulmoides, 2 parts of philippine flemingia root, 15 parts of plantain herb and 3 parts of beautiful millettia root.
Preferably, sesame oil or rapeseed oil is also included.
Preferably, the sesame oil is 500-800 parts by weight, and the rapeseed oil is 800-1000 parts by weight.
In a second aspect, the present application provides a method for preparing the traditional Chinese medicine composition for treating ankylosing spondylitis according to any one of the first aspect, comprising the following steps:
weighing the raw materials according to the weight portion, drying cassia twig, evening primrose, plantain, diverse wormwood herb and philippine flemingia root, and crushing into powder to obtain medicinal powder;
mixing semen Vaccariae, fructus Psoraleae, rhizoma Cibotii, eucommiae cortex and radix et rhizoma Rhei, adding oleum Sesami or oleum Rapae, heating, decocting, and filtering to remove residue to obtain medicinal oil;
heating the medicinal oil, slowly adding the medicinal powder, and adding pharmaceutically acceptable matrix.
Preferably, the pharmaceutically acceptable base comprises one or more of vegetable oil, animal oil, honey, wax, lanolin, petrolatum, glyceryl monostearate and stearyl alcohol.
Preferably, the traditional Chinese medicine composition is a paste and further comprises a dressing patch for bearing the traditional Chinese medicine composition.
Preferably, the heating and boiling temperature is 80-100 ℃, and the heating and boiling time is 30-60 min.
Preferably, the heating temperature of the medicinal oil is 50-60 ℃, and the medicinal powder is added under the heating and stirring states.
Compared with the prior art, the technical scheme provided by the embodiment of the application has at least the following advantages:
1. the traditional Chinese medicine composition provided by the application has the effects of opening the brown house, strengthening the spleen, tonifying qi and nourishing blood, raw materials required in the preparation process are natural, environment-friendly, safe, nontoxic, easily available and widely available materials, the preparation cost is low, the preparation method is simple, and the traditional Chinese medicine composition is used as paste without more professional technical assistance and is more practical for ordinary people.
2. The traditional Chinese medicine composition is not a simple combination of various medicinal materials, but is selected on the basis of considering the properties, taste, medicinal properties and incompatibility of various medicinal materials, and the prescription is prepared according to a certain proportion, and all the prescription have the functions of both organic coordination and mutual promotion. The Chinese medicinal composition has reasonable monarch, minister, assistant and guide compatibility, and all the medicaments are combined, can penetrate into the body through the skin directly, play the functions of promoting qi and activating blood, dispelling wind and dispelling cold of the medicament, is convenient to use, and is suitable for patients unsuitable for oral administration, inconvenient acupuncture or moxibustion due to various reasons.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present application are commercially available or may be prepared by existing methods.
In a first aspect, the application provides a traditional Chinese medicine composition for treating ankylosing spondylitis, which comprises the following raw materials in parts by weight:
30-50 parts of cassia twig, 10-20 parts of fructus psoraleae, 10-20 parts of diverse wormwood herb, 15-60 parts of cowherb seed, 30-50 parts of evening primrose, 40-60 parts of rhizoma cibotii, 5-15 parts of eucommia ulmoides, 1-10 parts of philippine flemingia root, 10-30 parts of plantain herb and 1-10 parts of beautiful millettia root.
The traditional Chinese medicine composition can treat common orthopedic diseases such as vertebral disease, lumbar vertebra disease, disc herniation, scapulohumeral periarthritis, sciatica, hyperosteogeny, rheumatic arthritis, ankylosing spondylitis, traumatic injury, sprain, fracture and the like, wherein the traditional Chinese medicine composition has a particularly effective curative effect on ankylosing spondylitis, and has no side effect and no dependence. For patients suffering from ankylosing spondylitis for a long time, a plurality of treatment courses are needed, and the traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, regulating qi and relieving pain, and also has a certain effect on improving the immunity of the patients after recovery.
Various embodiments of the application may exist in a range of forms; it should be understood that the description in a range format is merely for convenience and brevity and should not be construed as a rigid limitation on the scope of the application; it is therefore to be understood that the range description has specifically disclosed all possible sub-ranges and individual values within that range. For example, it should be considered that a description of a range from 1 to 6 has specifically disclosed sub-ranges, such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as single numbers within the range, such as 1, 2, 3, 4, 5, and 6, wherever applicable. In addition, whenever a numerical range is referred to herein, it is meant to include any reference number (fractional or integer) within the indicated range.
Specifically, the weight portion of the cassia twig can be 30 portions, 32 portions, 35 portions, 40 portions, 42 portions, 43 portions, 45 portions, 47 portions, 48 portions or 50 portions, etc.
The parts by weight of the fructus psoraleae can be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts and the like.
The weight parts of diverse wormwood herb can be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts and the like.
The weight parts of the seed of cowherb can be 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45 parts, 50 parts, 55 parts or 60 parts, etc.
The evening primrose may be 30 parts, 31 parts, 33 parts, 35 parts, 36 parts, 37 parts, 39 parts, 40 parts, 42 parts, 44 parts, 45 parts, 46 parts, 48 parts, 50 parts, etc.
The weight parts of the rhizoma cibotii can be 40 parts, 41 parts, 42 parts, 43 parts, 44 parts, 45 parts, 46 parts, 47 parts, 48 parts, 49 parts, 50 parts, 51 parts, 52 parts, 53 parts, 54 parts, 55 parts, 56 parts, 57 parts, 58 parts, 59 parts, 60 parts or the like.
The weight parts of eucommia can be 5 parts, 6 parts, 7.5 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 14.5 parts or 15 parts, etc.
The weight portion of the philippine flemingia root can be 1 portion, 2 portions, 3 portions, 4 portions, 5 portions, 6 portions, 7 portions, 8 portions, 9 portions or 10 portions, etc.
The parts by weight of the cart may be 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts, 30 parts, or the like.
And, the weight parts of the millettia speciosa champ can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, etc.
In the application, cassia twig is pungent and sweet in taste, warm in nature, enters heart, lung and bladder meridians, and has the effects of inducing sweat to relieve muscle, warming and activating meridians, supporting yang to transform qi, and calming the pulse to reduce qi. The medical Yingzhong Shenxi Ji (Chinese character of the application) has cloud: it has effects in dispersing exterior and interior, regulating nutrient and defensive qi, warming muscle, promoting blood circulation, relieving exterior syndrome, and relieving paralysis. Gui Zhi can induce sweat to relieve exterior syndrome and also can strengthen yang. It can be used for treating wind-cold invasion, injury of the skin and exterior, no matter the exterior is deficient or excessive. Modern pharmacological researches have found that cassia twig contains volatile oil and has the effects of regulating immunity, resisting inflammation, easing pain, inhibiting osteoclast, promoting osteoblast proliferation, resisting oxidation, promoting glycolipid metabolism and the like.
Bu Gu Zhi is sweet in flavor and neutral in nature. Enter kidney and lung meridians. Has effects of tonifying deficiency, moistening lung, strengthening tendons and activating collaterals, and can be used for treating lumbar muscle strain, rheumarthritis, lung heat, cough due to deficiency of lung, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, spermatorrhea, and leucorrhea. The drug theory states that "main man's lumbago, cold knee capsule dampness, various Leng Bi stubbles, convenience in stopping small and cold abdomen". Fructus Psoraleae can treat diseases, improve disease resistance, strengthen physical strength, promote phagocytic ability of macrophages, promote regeneration of leukocytes in human body, and improve immunoglobulin activity in human body and immunity of patients.
Liu Huan is bitter and pungent in flavor and warm in nature. It enters heart, liver and spleen meridians. Has the functions of breaking blood, dredging channels, removing food retention, stopping bleeding and relieving swelling. Is mainly used for treating amenorrhea due to blood stagnation, dysmenorrhea, postpartum abdominal stasis, abdominal pain due to stagnation of food, traumatic injury, golden sore hemorrhage, hematuria, carbuncle toxin and scald. Materia medica true: herba Artemisiae Anomalae, bitter and slightly warm in taste, can break stasis and unblock menstruation, relieve symptoms and distention, stop bleeding from golden sore, relieve constipation and remove blood, and toxic materials due to decoction. In the people with the border blood, the body is very noble and free, the blood is beneficial to the stagnation but not going, the abdominal distention is even more and more, the blood is also stagnated but not received, the blood is beneficial to the bleeding, and the herba artemisiae is always a blood-breaking product, so that the stagnant people can be broken and passed, and the general people can be broken and received.
Vaccaria is bitter in flavor and neutral in nature. Enter liver and stomach meridians. Has effects of promoting blood circulation, dredging channels, promoting lactation, relieving swelling, inducing diuresis, and treating stranguria, and can be used for treating amenorrhea, dysmenorrhea, galactorrhea, acute mastitis swelling and pain, and stranguria. The book of this application describes "Jinchuang hemostatic, pain-relieving and thorny-inducing, wind-dispelling arthralgia and internal cold-dispelling". Long-term taking of the health care tea can reduce weight, resist aging and prolong life.
Evening primrose taste sweet; bitter; warm nature. Has the functions of dispelling wind-damp and strengthening tendons and bones. Wind-cold-dampness arthralgia; soreness and weakness of bones and muscles, promoting blood circulation and removing obstruction in collaterals; calming endogenous wind and suppressing hyperactive liver; swelling and sore healing. Chest pain; stroke hemiplegia; the internal movement of the wind; infantile hyperactivity; rheumatalgia; abdominal pain and diarrhea; dysmenorrhea; the fox confusion; sores and ulcers; eczema. Modern medicine shows that evening primrose oil can resist platelet aggregation and prevent thrombosis.
Rhizoma Cibotii is bitter and sweet in taste, warm in nature, enters liver and kidney meridians, and has the effects of dispelling wind-damp, tonifying liver and kidney and strengthening waist and knee. "Shennong Ben Cao Jing" means that: strong waist and back, slow shutdown, zhou Bihan wet knee pain, and good for the elderly). It is indicated for wind-cold-dampness obstruction with strong waist and back, and pain in waist and knees because it can dispel wind-damp and nourish liver and kidney. Modern pharmacological researches have proved that rhizoma Cibotii has the effects of anti-inflammatory, analgesic, antirheumatic, anti-osteoporosis, protecting liver, resisting oxidation, resisting cancer, treating body ulcer, promoting blood circulation, stopping bleeding, resisting platelet aggregation, protecting brain nerve, etc., and chemical components in rhizoma Cibotii extract have therapeutic effects on cardiovascular and cerebrovascular diseases, and have modern pharmacological support.
Du Zhongwei it is sweet and warm in nature and enters liver and kidney meridians. Has effects in nourishing liver and kidney, strengthening tendons and bones, and preventing miscarriage. Eucommia ulmoides is the third most frequently used in this study. Medicinal herbs: "Kidney Cold, kidney lumbago; the people are deficient and have strong body and wind; for use, it is not convenient to use. Eucommia ulmoides can make tendons and bones mutually similar, so it is good at treating spasm of tendons and vessels, pain due to lumbar rigidity and pain, lumbago due to kidney deficiency. Modern pharmacological researches show that eucommia ulmoides contains various chemical components such as lignans, flavonoids, iridoids and the like, and has the effects of resisting inflammation, resisting oxidation, resisting osteoporosis, regulating immunity, protecting liver and kidney, resisting tumor, preventing miscarriage, regulating blood sugar, blood fat, blood pressure and the like.
Qian Qiao is sweet and pungent in flavor and warm in nature. Has effects of dispelling pathogenic wind, removing dampness, removing blood stasis, and removing toxic substances. Is used for treating rheumatalgia, chronic nephritis, traumatic injury, carbuncle, swelling, and throat moth. The "Ling nan Ji Yao Lu" records "dispelling wind and removing dampness. For arthralgia of hands and feet, rheumatism in waist, traumatic injury, it can relax tendons and activate collaterals.
Da Qian is sweet and astringent and cool in nature. Can be used for treating urinary tract infection, lithangiuria, nephritic edema, tinea pedis edema, common cold cough, bronchitis, enteritis diarrhea, hypertension, acute conjunctivitis, glaucoma, and umbilical infection of newborn. Can be used for treating oliguria, edema, diarrhea due to summer heat and dampness, hematemesis, pyretic stranguria and pain, cough due to phlegm heat, carbuncle, skin sore, parotitis, aphtha, stomatocace, chronic bronchitis, and gouty arthritis.
Niu Dali is sweet in flavor and neutral in nature. Enter kidney and lung meridians. Has effects of tonifying deficiency, moistening lung, strengthening tendons and activating collaterals, and can be used for treating lumbar muscle strain, rheumarthritis, lung heat, cough due to deficiency of lung, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, spermatorrhea, and leucorrhea. The radix et rhizoma Rhei has effects of relaxing muscles and tendons, dredging collaterals, promoting blood circulation, and relieving pain, and can be used for relieving swelling and pain symptoms caused by rheumatalgia, traumatic injury, lumbar muscle strain, etc.
Preferably, the material comprises the following raw materials in parts by weight:
30-40 parts of cassia twig, 10-15 parts of fructus psoraleae, 15-20 parts of diverse wormwood herb, 15-30 parts of cowherb seed, 45-50 parts of evening primrose, 45-50 parts of rhizoma cibotii, 5-10 parts of eucommia ulmoides, 1-5 parts of philippine flemingia root, 10-20 parts of plantain herb and 1-5 parts of beautiful millettia root.
Preferably, the material comprises the following raw materials in parts by weight:
35 parts of cassia twig, 12 parts of fructus psoraleae, 18 parts of diverse wormwood herb, 30 parts of cowherb seed, 50 parts of evening primrose, 45 parts of rhizoma cibotii, 8 parts of eucommia ulmoides, 2 parts of philippine flemingia root, 15 parts of plantain herb and 3 parts of beautiful millettia root.
Preferably, sesame oil or rapeseed oil is also included.
Preferably, the sesame oil is 500-800 parts by weight, and the rapeseed oil is 800-1000 parts by weight.
In a second aspect, the present application provides a method for preparing the traditional Chinese medicine composition for treating ankylosing spondylitis according to any one of the first aspect, comprising the following steps:
weighing the raw materials according to the weight portion, drying cassia twig, evening primrose, plantain herb, diverse wormwood herb and philippine flemingia root, crushing into powder, and sieving with a 80-200 mesh sieve to obtain medicinal powder;
mixing semen Vaccariae, fructus Psoraleae, rhizoma Cibotii, eucommiae cortex and radix et rhizoma Rhei, adding 500-800 parts of sesame oil or 800-1000 parts of oleum Rapae, heating, decocting at 80-100deg.C for 30-60 min, and filtering to remove residue to obtain medicinal oil;
heating the medicinal oil to 50-60 ℃, slowly adding the medicinal powder in a heating and stirring state, adding a pharmaceutically acceptable matrix to prepare paste, and uniformly spreading the paste on a dressing patch.
Heating and decocting the above materials. The fire should not be too high to prevent the materials from burning and deteriorating, and it is usually decocted with slow fire.
Preferably, the pharmaceutically acceptable base comprises one or more of vegetable oil, animal oil, honey, wax, lanolin, petrolatum, glyceryl monostearate and stearyl alcohol.
Wherein the vegetable oil can be sesame oil, rapeseed oil, etc.
The principles and features of the present application are described below in connection with the following examples, which are set forth to illustrate, but are not to be construed as limiting the scope of the application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
Example 1
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
35g of cassia twig, 12g of fructus psoraleae, 18g of herba artemisiae, 30g of semen vaccariae, 50g of evening primrose, 45g of rhizoma cibotii, 8g of eucommia ulmoides, 2g of radix philippici, 15g of plantain herb and 3g of radix millettiae speciosa.
Example 2
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
30g of cassia twig, 10g of fructus psoraleae, 10g of herba artemisiae, 15g of semen vaccariae, 30g of evening primrose, 40g of rhizoma cibotii, 5g of eucommia ulmoides, 1g of radix philippici, 10g of plantain and 1g of radix millettiae speciosa.
Example 3
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
50g of cassia twig, 20g of fructus psoraleae, 20g of herba artemisiae, 60g of semen vaccariae, 50g of evening primrose, 60g of rhizoma cibotii, 15g of eucommia ulmoides, 10g of radix philippici, 30g of plantain herb and 10g of radix millettiae speciosa.
Example 4
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
40g of cassia twig, 15g of fructus psoraleae, 15g of herba artemisiae, 20g of semen vaccariae, 45g of evening primrose, 45g of rhizoma cibotii, 10g of eucommia ulmoides, 2g of radix philippici, 15g of plantain herb and 6g of radix millettiae speciosa.
Example 5
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
32g of cassia twig, 18g of fructus psoraleae, 16g of herba artemisiae, 50g of semen vaccariae, 45g of evening primrose, 42g of rhizoma cibotii, 8g of eucommia ulmoides, 5g of radix philippici, 15g of plantain herb and 5g of radix millettiae speciosa.
Example 6
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
50g of cassia twig, 10g of fructus psoraleae, 10g of herba artemisiae, 60g of semen vaccariae, 30g of evening primrose, 60g of rhizoma cibotii, 5g of eucommia ulmoides, 6g of radix philippici, 10g of plantain and 4g of radix millettiae speciosa.
Example 7
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
35g of cassia twig, 18g of fructus psoraleae, 12g of herba artemisiae, 28g of semen vaccariae, 36g of evening primrose, 42g of rhizoma cibotii, 8g of eucommia ulmoides, 3g of radix philippici, 25g of plantain herb and 7g of radix millettiae speciosa.
Example 8
A Chinese medicinal composition for treating ankylosing spondylitis comprises the following raw materials in part by weight:
40g of cassia twig, 15g of fructus psoraleae, 18g of herba artemisiae, 30g of semen vaccariae, 40g of evening primrose, 50g of rhizoma cibotii, 12g of eucommia ulmoides, 7g of radix philippici, 27g of plantain and 3g of radix millettiae speciosa.
Example 9
The traditional Chinese medicine composition for treating ankylosing spondylitis of the above examples 1-8 is prepared by the following method:
weighing the raw materials according to the weight ratio, drying cassia twig, evening primrose, plantain, diverse wormwood herb and philippine flemingia root, pulverizing into powder, and sieving with a 80-mesh sieve to obtain medicinal powder;
mixing semen Vaccariae, fructus Psoraleae, rhizoma Cibotii, eucommiae cortex and radix et rhizoma Rhei, adding 1000g oleum Rapae, heating, decocting at 100deg.C for 30min, and filtering to remove residue to obtain medicinal oil;
heating the medicinal oil to 50deg.C, slowly adding medicinal powder under heating and stirring, adding small amount of vaseline to obtain paste, spreading the paste on 15x15cm plaster cloth, and weighing about 12g per patch.
Specific cases:
symptoms that are judged to be ankylosing spondylitis include:
(1) Main symptoms are as follows: lumbosacral pain, back pain, limited movement of the back, severe morning stiffness, severe cold, reduced heat, cold hands and feet, and heel pain;
(2) Secondary symptoms: cold pain in the joints of the limbs, heavy limbs, listlessness, lusterless complexion, soreness and weakness of the waist and knees, spermatorrhea;
(3) Tongue pulse: a pale tongue with white coating or slippery water and a wiry slippery pulse.
Judgment standard: satisfying 2 main symptoms +1 secondary symptoms or 2 main symptoms + tongue pulse or 1 main symptoms +2 secondary symptoms + tongue pulse.
The using method comprises the following steps: the affected part is firstly washed by sterile water or warm boiled water and light brine, and is washed by white wine or medicinal liquor, and then the plaster prepared by the proportion of the embodiment 1 of the application is baked by fire or infrared lamp, gas fire source and the like and then is stuck on the affected part, one paste is stuck every three days, and 7 pastes are taken as one treatment course, and three (or more) treatment courses are treated.
The traditional Chinese medicine composition is not suitable for pregnant women, metrorrhagia women or women in lactation period, mental patients and the like, and is also not suitable for patients with allergic symptoms to the medicine in the formula.
Case 1: luo Mou male, 39 years old, lumbosacral pain, restricted movement, debilitation, loose stool and normal urination. Dark tongue with thick and greasy coating and weak pulse. After three treatment courses of the plaster of the embodiment 1 of the application are used, the pain of the waist is obviously relieved, the stool is normal, the joint movement degree is increased, and after two treatment courses, the pain of the waist is disappeared and the rest symptoms are not obvious.
Case 2: some women, 45 years old, pain in the back, listlessness, soreness of the waist and knees, pale tongue with thin and white coating, deep and wiry pulse. After three treatment courses of the plaster of the embodiment 1 of the application, the tongue is light red, the coating is thin and white, and the pulse is wiry. The illness state of the patient is stable, and symptoms disappear.
Case 3: yang Mou A, 46 years old, cold pain in waist and limbs, localized aversion to cold, aggravation in cold and lightening in heat, and wiry and tight pulse. After three treatment courses of the plaster of the embodiment 1 of the application are used, the joint movement is also partially limited, but the life and the work are not affected, and the aversion to cold is improved; the medicine is continuously used for three courses of treatment, clinical symptoms disappear, and no recurrence occurs after return visit.
Case 4: chen Mou A, 35 years old, pain in the back and excessive months, stiff feeling, mild tenderness in joints, mild impaired activity, aversion to cold, nocturia, distention of the stomach, and loose stool. The plaster of the embodiment 1 of the application is applied to the affected part for treatment, pain disappears after 3 treatment courses, slight discomfort exists after the affected part, and the illness state is stable after 1 treatment course is consolidated.
Case 5: guo somewhere, male, 41 years old, spinal pain, obvious morning stiffness, hypodynamia, emaciation, mild anemia and persistent low fever. The plaster of the embodiment 1 of the application is applied to the affected part for treatment, and after 3 treatment courses, various symptoms basically disappear; consolidation was carried out with continued treatment with the plaster of example 1 of the present application for 2 courses of treatment. After half a year, return visit is made to all normal.
The foregoing is only a specific embodiment of the application to enable those skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A traditional Chinese medicine composition for treating ankylosing spondylitis is characterized by comprising the following raw materials in parts by weight:
30-50 parts of cassia twig, 10-20 parts of fructus psoraleae, 10-20 parts of diverse wormwood herb, 15-60 parts of cowherb seed, 30-50 parts of evening primrose, 40-60 parts of rhizoma cibotii, 5-15 parts of eucommia ulmoides, 1-10 parts of philippine flemingia root, 10-30 parts of plantain herb and 1-10 parts of beautiful millettia root.
2. The traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight:
30-40 parts of cassia twig, 10-15 parts of fructus psoraleae, 15-20 parts of diverse wormwood herb, 15-30 parts of cowherb seed, 45-50 parts of evening primrose, 45-50 parts of rhizoma cibotii, 5-10 parts of eucommia ulmoides, 1-5 parts of philippine flemingia root, 10-20 parts of plantain herb and 1-5 parts of beautiful millettia root.
3. The traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 1 or 2, characterized by comprising the following raw materials in parts by weight:
35 parts of cassia twig, 12 parts of fructus psoraleae, 18 parts of diverse wormwood herb, 30 parts of cowherb seed, 50 parts of evening primrose, 45 parts of rhizoma cibotii, 8 parts of eucommia ulmoides, 2 parts of philippine flemingia root, 15 parts of plantain herb and 3 parts of beautiful millettia root.
4. The traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 1 or 2, further comprising sesame oil or rapeseed oil.
5. The traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 4, wherein the sesame oil is 500-800 parts by weight and the rapeseed oil is 800-1000 parts by weight.
6. A method for preparing a traditional Chinese medicine composition for treating ankylosing spondylitis according to any one of claims 1 to 5, characterized by comprising the following steps:
weighing the raw materials according to the weight portion, drying cassia twig, evening primrose, plantain, diverse wormwood herb and philippine flemingia root, and crushing into powder to obtain medicinal powder;
mixing semen Vaccariae, fructus Psoraleae, rhizoma Cibotii, eucommiae cortex and radix et rhizoma Rhei, adding oleum Sesami or oleum Rapae, heating, decocting, and filtering to remove residue to obtain medicinal oil;
heating the medicinal oil, slowly adding the medicinal powder, and adding pharmaceutically acceptable matrix.
7. The method of claim 6, wherein the pharmaceutically acceptable base comprises one or more of vegetable oil, animal oil, honey, wax, lanolin, petrolatum, glyceryl monostearate, and stearyl alcohol.
8. The method for preparing a traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 6, wherein the traditional Chinese medicine composition is a paste and further comprises a dressing for bearing the traditional Chinese medicine composition.
9. The method for preparing a traditional Chinese medicine composition for treating ankylosing spondylitis according to claim 6, wherein the heating and boiling temperature is 80-100 ℃ and the heating and boiling time is 30-60 min.
10. The method for preparing a pharmaceutical composition for treating ankylosing spondylitis according to claim 6, wherein the temperature of heating the medicinal oil is 50 to 60 ℃, and the medicinal powder is added in a heated and stirred state.
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