CN117137432A - Parathyroid gland identification and blood supply detection device and detection method - Google Patents
Parathyroid gland identification and blood supply detection device and detection method Download PDFInfo
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- CN117137432A CN117137432A CN202310583002.7A CN202310583002A CN117137432A CN 117137432 A CN117137432 A CN 117137432A CN 202310583002 A CN202310583002 A CN 202310583002A CN 117137432 A CN117137432 A CN 117137432A
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- 238000001514 detection method Methods 0.000 title claims abstract description 140
- 230000036770 blood supply Effects 0.000 title claims abstract description 57
- 210000002990 parathyroid gland Anatomy 0.000 title claims abstract description 27
- 239000013307 optical fiber Substances 0.000 claims abstract description 78
- 230000000849 parathyroid Effects 0.000 claims abstract description 66
- 230000003287 optical effect Effects 0.000 claims abstract description 24
- 238000004458 analytical method Methods 0.000 claims abstract description 16
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 23
- 229910052760 oxygen Inorganic materials 0.000 claims description 23
- 239000001301 oxygen Substances 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 10
- 238000004364 calculation method Methods 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 17
- 230000005284 excitation Effects 0.000 description 8
- 239000000835 fiber Substances 0.000 description 5
- 210000001685 thyroid gland Anatomy 0.000 description 5
- 230000004044 response Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000000691 measurement method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000003982 Parathyroid hormone Human genes 0.000 description 1
- 108090000445 Parathyroid hormone Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000003372 endocrine gland Anatomy 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000199 parathyroid hormone Substances 0.000 description 1
- 229960001319 parathyroid hormone Drugs 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 201000002510 thyroid cancer Diseases 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14556—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases by fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14557—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted to extracorporeal circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4887—Locating particular structures in or on the body
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- Health & Medical Sciences (AREA)
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- Physics & Mathematics (AREA)
- Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
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- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The embodiment of the invention discloses a parathyroid gland identification and blood supply detection device and a detection method, wherein the device comprises an incident light path, a receiving light path and a light path detection analysis module; the incident light path comprises a near infrared light source, a red light source and an incident optical fiber; the receiving optical path comprises a receiving optical fiber; the light path detection analysis module comprises a light intensity detector and a main control circuit board, wherein the light intensity detector receives light transmitted by the receiving optical fiber, and the main control circuit board is connected with the near infrared light source, the red light source and the light intensity detector; the incident optical fiber guides near infrared light emitted by the near infrared light source and red light emitted by the red light source to a detection target; the receiving optical fiber receives the self-fluorescence and the reflected light of the detection target object. The invention has the capability of simultaneously carrying out parathyroid recognition and blood supply detection, has simple structure and relatively low cost, and is convenient for popularization and use.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to a parathyroid recognition and blood supply detection device and a detection method.
Background
Parathyroid gland is an important endocrine gland of human body, mainly secretes parathyroid hormone, regulates calcium and phosphorus metabolism of human body, and has very key effect. The protection of parathyroid glands in thyroid surgery is an important index for evaluating the quality of thyroid surgery, and in traditional radical thyroid cancer treatment, the identification of parathyroid glands and the judgment of blood supply indexes including blood oxygen and pulse information mainly depend on clinical operation experience of doctors, so that the unified operation curative effect is difficult, and the parathyroid glands can be identified and can be detected by using medical technology, so that the method has important clinical significance.
The optical detection technology is a novel parathyroid recognition and blood supply detection technology developed in recent years. When the parathyroid gland is excited by the excitation light source, the autofluorescence with the peak value near 820nm is generated, and obvious distinction is made between the autofluorescence and thyroid gland, lymph, fat and the like around the autofluorescence, and the optical recognition of the parathyroid gland can be performed by utilizing the characteristic; by utilizing the difference of absorption spectra of different components in blood, the detection of blood supply parameters such as blood oxygen, pulse and the like can be realized by using a photo-capacitance product method. At present, most of parathyroid gland detection products in the market have single functions, and the capability of simultaneously carrying out parathyroid gland identification and blood supply detection by one machine is not provided.
Disclosure of Invention
The invention aims to provide a parathyroid gland identification and blood supply detection device and a parathyroid gland identification and blood supply detection method, which are used for solving at least one technical problem.
Embodiments of the present invention are implemented as follows:
the parathyroid gland recognition and blood supply detection device comprises an incident light path, a receiving light path and a light path detection analysis module, wherein the incident light path emits a light path to a detection target object 7, the receiving light path receives autofluorescence and reflected light of the detection target object 7, and the light path analysis module is respectively connected with the incident light path and the receiving light path.
The incident light path comprises a near infrared light source 1, a red light source 4 and an incident optical fiber 6, wherein light paths emitted by the infrared light source 1 and the red light source 4 are respectively coupled into the incident optical fiber 6.
The receive optical path includes a receive optical fiber 8.
The light path detection analysis module comprises a light intensity detector and a main control circuit board 13, wherein the light intensity detector receives light transmitted by the receiving optical fiber 8, and the main control circuit board 13 is connected with the near infrared light source 1, the red light source 4 and the light intensity detector.
In the preferred embodiment of the present invention, the incident optical fiber 6 of the parathyroid recognition and blood supply detection device guides the near infrared light emitted from the near infrared light source 1 and the red light emitted from the red light source 4 to the detection target 7.
The receiving fiber 8 receives the autofluorescence and the reflected light of the detection target 7.
The technical effects are as follows: for irradiating the detection target 7, and optically recognizing by receiving the autofluorescence and reflected light of the detection target 7.
In a preferred embodiment of the present invention, the incident light path of the parathyroid recognition and blood supply detection device further includes a near infrared band-pass filter 3 and a first dichroic mirror 5.
The near infrared band pass filter 3 is disposed on the light emitting side of the near infrared light source 1.
The first dichroic mirror 5 is disposed at the light emitting side of the near infrared light source 1 and the light emitting side of the red light source 4.
The incident optical fiber 6 receives light passing through and reflected by the first dichroic mirror 5.
The technical effects are as follows: the bandpass filter allows only light of a specific wavelength band to pass. The near infrared band pass filter 3 allows near infrared light to pass.
The dichroic mirror is almost completely transparent to light of a certain wavelength and almost completely reflective to light of other wavelengths. The first dichroic mirror 5 has an initial response wavelength between the near infrared light source wavelength and the red light source wavelength, and can pass near infrared light and reflect red light.
In a preferred embodiment of the present invention, a first convex lens 201 is disposed between the near infrared light source 1 and the near infrared band-pass filter 3 of the parathyroid recognition and blood supply detection device.
A second convex lens 202 is arranged between the red light source 4 and the first dichroic mirror 5.
A third convex lens 203 is arranged between the first dichroic mirror 5 and the incident optical fiber 6.
The technical effects are as follows: and a convex lens is arranged to realize collimation or focusing of light.
In a preferred embodiment of the present invention, the light intensity detector of the parathyroid recognition and blood supply detection device includes a first light intensity detector 11 and a second light intensity detector 12.
In a preferred embodiment of the present invention, the receiving optical path of the parathyroid recognition and blood supply detection device further includes a fluorescent bandpass filter 10 and a second dichroic mirror 9.
The second dichroic mirror 9 is disposed at the light-emitting side of the receiving optical fiber 8.
The fluorescence bandpass filter 10 is provided on the light-transmitting side of the second dichroic mirror 9.
The technical effects are as follows: the second dichroic mirror 9 has an initial response wavelength between the parathyroid tissue fluorescence wavelength and the near-red light source wavelength, and is capable of passing tissue fluorescence and reflecting near-infrared light. The fluorescence band-pass filter 10 is used for passing parathyroid fluorescence and cutting off stray light in other wave bands.
In a preferred embodiment of the present invention, the first light intensity detector 11 of the parathyroid recognition and blood supply detection device is disposed on the reflected light side of the second dichroic mirror 9, receives the light reflected from the second dichroic mirror 9, and converts the light signal into an electrical signal.
The technical effects are as follows: the light intensity signal related to the parathyroid oxygen and the pulse is converted into an electric signal.
In a preferred embodiment of the present invention, the second light intensity detector 12 of the parathyroid recognition and blood supply detection device is disposed on the light passing side of the fluorescent band-pass filter 10, receives the light passing through the second dichroic mirror 9, and converts the light signal into an electrical signal.
The technical effects are as follows: the light intensity signal of parathyroid fluorescence is converted into an electrical signal.
In the preferred embodiment of the present invention, a fourth convex lens 204 is disposed between the receiving fiber 8 and the second dichroic mirror 9 of the parathyroid recognition and blood supply detection device.
A fifth convex lens 205 is arranged between the first light intensity detector 11 and the second dichroic mirror 9.
A sixth convex lens 206 is arranged between the fluorescent bandpass filter 10 and the second light intensity detector 12.
In a preferred embodiment of the present invention, the optical path detection and analysis module of the parathyroid gland recognition and blood supply detection device further includes a display terminal 14, where the display terminal 14 is connected to the main control circuit board 13, and displays the fluorescence, blood oxygen and pulse data of the parathyroid gland and the operation interface.
The technical effects are as follows: the main control circuit board 13 drives and controls the two light sources of the near infrared light source 1 and the red light source 4 to be turned on and turned off and to modulate the respective luminous intensity, receives the data of the two light intensity detectors, performs calculation and analysis according to a certain algorithm, and outputs information related to fluorescence, blood oxygen and pulse to the display terminal 14.
A method of testing using a parathyroid recognition and blood supply testing device as hereinbefore described, comprising:
the detection optical fiber is close to the detection target object 7, the detection optical fiber comprises an incident optical fiber 6 and a receiving optical fiber 8, a main control circuit board 13 controls the near infrared light source 1 to be started and the red light source 4 to be closed, and the main control circuit board 13 receives a detection signal to judge whether the detection target object 7 is parathyroid gland tissue.
If the detection target 7 is parathyroid tissue, the main control circuit board 14 controls the near infrared light source 1 and the red light source 4 to be turned on, adjusts the light emitting power of the infrared light source 1 and the light emitting power of the red light source 4 to match, and the main control circuit board 13 receives the detection signal to obtain blood oxygen and pulse information of the detection target 7.
In a preferred embodiment of the present invention, the method for detecting the parathyroid recognition and blood supply detection device includes:
the light path is guided to the detection target object 7 through the incident optical fiber 6, and the self-fluorescence and the reflected light of the detection target object 7 are received through the receiving optical fiber 8.
The second light intensity detector 12 receives and converts the fluorescence intensity signal into a corresponding electrical signal, and transmits the electrical signal to the main control circuit board 13, and the main control circuit board 13 determines whether the detection target 7 is parathyroid tissue according to a preset algorithm, and sends detection information to the display terminal 14.
In a preferred embodiment of the present invention, the parathyroid recognition and blood supply detection device includes:
the infrared light source 1 and the red light source 4 flash alternately at the same frequency.
Both optical paths are guided to the detection target 7 through the incident optical fiber 6, and reflected light of the detection target 7 is received through the receiving optical fiber 8.
The first light intensity detector 11 receives and converts the fluorescence intensity signal into a corresponding electrical signal, the electrical signal is transmitted to the main control circuit board 13, and the main control circuit board 13 obtains the blood oxygen and pulse information of the detection target 7 after processing and calculating, and sends the blood oxygen and pulse information to the display terminal 14.
The embodiment of the invention has the beneficial effects that:
the invention provides an integrated parathyroid gland identification and blood supply detection device and method. The device designs a combined measurement method for parathyroid optical identification and blood supply detection according to the device, is accurate and rapid, and is suitable for being used in thyroid operation.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a parathyroid recognition and blood supply detection device according to the present invention;
FIG. 2 is a flow chart of a method of detecting parathyroid recognition and blood supply detection apparatus of the present invention;
FIG. 3 is a schematic diagram showing the whole flow of the combined measurement method of parathyroid recognition and blood supply detection for parathyroid optical recognition and blood supply detection by the parathyroid recognition and blood supply detection device of the present invention.
In the figure: 1-a near infrared light source; 201-a first convex lens; 202-a second convex lens; 203-a third convex lens; 204-a fourth convex lens; 205-a fifth convex lens; 206-a sixth convex lens; 3-near infrared bandpass filters; 4-a red light source; 5-a first dichroic mirror; 6-an incident optical fiber; 7-detecting a target; 8-receiving an optical fiber; 9-a second dichroic mirror; 10-a fluorescent bandpass filter; 11-a first light intensity detector; 12-a second light intensity detector; 13-a main control circuit board; 14-display terminal.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. The components of the embodiments of the present invention generally described and illustrated in the figures herein can be arranged and designed in a wide variety of different configurations.
Referring to fig. 1, a first embodiment of the present invention provides a parathyroid gland recognition and blood supply detection device, which includes an incident light path, a receiving light path and a light path detection analysis module, wherein the incident light path emits a light path to a detection target object 7, the receiving light path receives auto-fluorescence and reflected light of the detection target object 7, and the light path analysis module is respectively connected to the incident light path and the receiving light path.
The incident light path comprises a near infrared light source 1, a red light source 4 and an incident optical fiber 6, wherein light paths emitted by the infrared light source 1 and the red light source 4 are respectively coupled into the incident optical fiber 6.
The red light source 4 has a red light wavelength of 600-700nm, typically 660 nm. Is matched with a near infrared light source to detect parathyroid blood oxygen and pulse signals.
The near infrared light source 1 has a near infrared wavelength of between 750 and 790nm, typically 785 nm. Can be used as an excitation light source for parathyroid fluorescence detection independently, and can also be matched with a red light source 4 to detect parathyroid blood oxygen and pulse.
The two light sources of the near infrared light source 1 and the red light source 4 may be laser light sources or non-laser light sources such as LEDs.
The receive optical path includes a receive optical fiber 8.
The light path detection analysis module comprises a light intensity detector and a main control circuit board 13, wherein the light intensity detector receives light transmitted by the receiving optical fiber 8, and the main control circuit board 13 is connected with the near infrared light source 1, the red light source 4 and the light intensity detector.
In the preferred embodiment of the present invention, the incident optical fiber 6 of the parathyroid recognition and blood supply detection device guides the near infrared light emitted from the near infrared light source 1 and the red light emitted from the red light source 4 to the detection target 7.
The receiving fiber 8 receives the autofluorescence and the reflected light of the detection target 7.
The incident optical fiber 6 and the receiving optical fiber 8 may be two independent optical fibers, or may be a dual-core Y-shaped optical fiber, or a multi-core Y-shaped optical fiber with one or more cores, or may be space light irradiation and receiving instead of the incident optical fiber 6 and the receiving optical fiber 8.
Wherein the detection target 7 is parathyroid tissue.
Preferably, the fiber optic measurement site may be formed as an elongated straight probe or as a curved probe shape to facilitate measurement.
The technical effects are as follows: for irradiating the detection target 7, and optically recognizing by receiving the autofluorescence and reflected light of the detection target 7.
In a preferred embodiment of the present invention, the incident light path of the parathyroid recognition and blood supply detection device further includes a near infrared band-pass filter 3 and a first dichroic mirror 5.
The near infrared band pass filter 3 is disposed on the light emitting side of the near infrared light source 1.
The first dichroic mirror 5 is disposed at the light emitting side of the near infrared light source 1 and the light emitting side of the red light source 4.
The incident optical fiber 6 receives light passing through and reflected by the first dichroic mirror 5.
The technical effects are as follows: the bandpass filter allows only light of a specific wavelength band to pass. The near infrared band pass filter 3 allows near infrared light to pass.
The dichroic mirror is almost completely transparent to light of a certain wavelength and almost completely reflective to light of other wavelengths. The first dichroic mirror 5 has an initial response wavelength between the near infrared light source wavelength and the red light source wavelength, and can pass near infrared light and reflect red light.
In a preferred embodiment of the present invention, a first convex lens 201 is disposed between the near infrared light source 1 and the near infrared band-pass filter 3 of the parathyroid recognition and blood supply detection device.
A second convex lens 202 is arranged between the red light source 4 and the first dichroic mirror 5.
A third convex lens 203 is arranged between the first dichroic mirror 5 and the incident optical fiber 6.
The technical effects are as follows: and a convex lens is arranged to realize collimation or focusing of light.
In a preferred embodiment of the present invention, the light intensity detector of the parathyroid recognition and blood supply detection device includes a first light intensity detector 11 and a second light intensity detector 12.
In a preferred embodiment of the present invention, the receiving optical path of the parathyroid recognition and blood supply detection device further includes a fluorescent bandpass filter 10 and a second dichroic mirror 9.
The second dichroic mirror 9 is disposed at the light-emitting side of the receiving optical fiber 8.
The fluorescence bandpass filter 10 is provided on the light-transmitting side of the second dichroic mirror 9.
The technical effects are as follows: the second dichroic mirror 9 has an initial response wavelength between the parathyroid tissue fluorescence wavelength and the near-red light source wavelength, and is capable of passing tissue fluorescence and reflecting near-infrared light. The fluorescence band-pass filter 10 is used for passing parathyroid fluorescence and cutting off stray light in other wave bands.
In a preferred embodiment of the present invention, the first light intensity detector 11 of the parathyroid recognition and blood supply detection device is disposed on the reflected light side of the second dichroic mirror 9, receives the light reflected from the second dichroic mirror 9, and converts the light signal into an electrical signal.
The technical effects are as follows: the light intensity signal related to the parathyroid oxygen and the pulse is converted into an electric signal.
In a preferred embodiment of the present invention, the second light intensity detector 12 of the parathyroid recognition and blood supply detection device is disposed on the light passing side of the fluorescent band-pass filter 10, receives the light passing through the second dichroic mirror 9, and converts the light signal into an electrical signal.
The technical effects are as follows: the light intensity signal of parathyroid fluorescence is converted into an electrical signal.
The first light intensity detector 11 and the second light intensity detector 12 may be photoelectric conversion devices such as PD, APD, PTM, spectrometers connected by optical fibers, or a combination thereof.
In the preferred embodiment of the present invention, a fourth convex lens 204 is disposed between the receiving fiber 8 and the second dichroic mirror 9 of the parathyroid recognition and blood supply detection device.
A fifth convex lens 205 is arranged between the first light intensity detector 11 and the second dichroic mirror 9.
A sixth convex lens 206 is arranged between the fluorescent bandpass filter 10 and the second light intensity detector 12.
In a preferred embodiment of the present invention, the optical path detection and analysis module of the parathyroid gland recognition and blood supply detection device further includes a display terminal 14, where the display terminal 14 is connected to the main control circuit board 13, and displays the fluorescence, blood oxygen and pulse data of the parathyroid gland and the operation interface.
When measuring blood oxygen and pulse parameters, the main control circuit board 13 modulates the luminous power of the near infrared light source 1 to be reduced to a level matched with the red light source 4.
The technical effects are as follows: the main control circuit board 13 drives and controls the two light sources of the near infrared light source 1 and the red light source 4 to be turned on and turned off and to modulate the respective luminous intensity, receives the data of the two light intensity detectors, performs calculation and analysis according to a certain algorithm, and outputs information related to fluorescence, blood oxygen and pulse to the display terminal 14.
Referring to fig. 1 to 3, a second embodiment of the present invention provides a method for combined measurement of parathyroid identification and blood supply detection for parathyroid optical identification and blood supply detection thereof, comprising:
as shown in fig. 2, a detection optical fiber is attached to the detection target object 7, the detection optical fiber includes an incident optical fiber 6 and a receiving optical fiber 8, a main control circuit board 13 controls the near infrared light source 1 to be turned on, the red light source 4 to be turned off, and the main control circuit board 13 receives a detection signal to determine whether the detection target object 7 is parathyroid tissue.
If the detection target 7 is parathyroid tissue, the main control circuit board 14 controls the near infrared light source 1 and the red light source 4 to be turned on, adjusts the light emitting power of the infrared light source 1 and the light emitting power of the red light source 4 to match, and the main control circuit board 13 receives the detection signal to obtain blood oxygen and pulse information of the detection target 7.
As shown in fig. 3, in a preferred embodiment of the present invention, the method for detecting the parathyroid recognition and blood supply detection device includes:
the light path is guided to the detection target object 7 through the incident optical fiber 6, and the self-fluorescence and the reflected light of the detection target object 7 are received through the receiving optical fiber 8.
The near infrared light is used as excitation light of parathyroid gland, is collimated by the first convex lens 201, filtered by the band-pass filter to remove component light outside the excitation band, passes through the first dichroic mirror 5, and is focused and converged into the incident optical fiber 6 by the third convex lens 203. The incident optical fiber 6 guides the excitation light to the surface of the tissue to be measured, and if the tissue to be measured is parathyroid, fluorescence with a peak wavelength of 820nm is generated more strongly than that of other tissues. The fluorescence is received by the receiving optical fiber 8 together with other stray light; the receiving optical fiber 8 introduces the received light into the receiving optical path, after being collimated by the fourth convex lens 204, the stray light is filtered by the second dichroic mirror 9 and the fluorescent bandpass filter 10, only the nearby wave band is allowed to pass, and then the light is focused on the photosurface of the second light intensity detector 12 by the sixth convex lens 206.
The near infrared light is used as excitation light of parathyroid gland, is collimated by the first convex lens 201, filtered by the band-pass filter to remove component light outside the excitation band, passes through the first dichroic mirror 5, and is focused and converged into the incident optical fiber 6 by the third convex lens 203. The incident optical fiber 6 guides the excitation light to the surface of the tissue to be measured, and if the tissue to be measured is parathyroid, fluorescence with a peak wavelength of 820nm is generated more strongly than that of other tissues. The fluorescence is received by the receiving optical fiber 8 together with other stray light; the receiving optical fiber 8 introduces the received light into the receiving optical path, after being collimated by the fourth convex lens 204, the stray light is filtered by the second dichroic mirror 9 and the fluorescent bandpass filter 10, only the nearby wave band is allowed to pass, and then the light is focused on the photosurface of the second light intensity detector 12 by the sixth convex lens 206.
The second light intensity detector 12 receives and converts the fluorescence intensity signal into a corresponding electrical signal, and transmits the electrical signal to the main control circuit board 13, the main control circuit board 13 determines whether the detection target 7 is parathyroid tissue according to a preset algorithm, and sends detection information to the display terminal 14, so that a doctor can determine whether the detected tissue is parathyroid.
In a preferred embodiment of the present invention, the parathyroid recognition and blood supply detection device includes:
the infrared light source 1 and the red light source 4 flash alternately at the same frequency.
Both optical paths are guided to the detection target 7 through the incident optical fiber 6, and reflected light of the detection target 7 is received through the receiving optical fiber 8.
Wherein, near infrared light passes through the first dichroic mirror 5 after being collimated by the first convex lens 201 and the bandpass filter, and is focused and converged into the incident optical fiber 6 by the lens; meanwhile, the red light is collimated by the lens, reflected by the first dichroic mirror 5, focused by the third convex lens 203 and converged into the incident optical fiber 6. The incident optical fiber 6 guides the light of the two wavelengths to the surface of the tissue to be measured, and a part of the incident light is absorbed by the tissue and the other part is reflected by the tissue and received by the receiving optical fiber 8. The receiving optical fiber 8 introduces the received light into the receiving optical path, after being collimated by the fourth convex lens 204, the received light is reflected by the second dichroic mirror 9, and finally is focused on the photosurface of the first light intensity detector 11 by the fifth convex lens 205.
The first light intensity detector 11 receives and converts the fluorescence intensity signal into a corresponding electrical signal, the corresponding electrical signal is transmitted to the main control circuit board 13, the main control circuit board 13 obtains the blood oxygen and pulse information of the detection target 7 after processing and calculation, and the blood oxygen and pulse information is transmitted to the display terminal 14, so that a doctor can judge the blood supply condition of the tissue to be detected at the position.
The embodiment of the invention aims to protect a parathyroid recognition and blood supply detection device and a detection method, and has the following effects:
by organically integrating the parathyroid optical recognition detection light path with the blood oxygen and pulse detection light path, the parathyroid recognition and blood supply detection functions are realized by using one set of light path, and the device has the advantages of exquisite structure and low cost. The device designs a combined measurement method for parathyroid optical identification and blood supply detection according to the device, is accurate and rapid, and is suitable for being used in thyroid operation.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explanation of the principles of the present invention and are in no way limiting of the invention. Accordingly, any modification, equivalent replacement, improvement, etc. made without departing from the spirit and scope of the present invention should be included in the scope of the present invention. Furthermore, the appended claims are intended to cover all such changes and modifications that fall within the scope and boundary of the appended claims, or equivalents of such scope and boundary.
Claims (10)
1. The parathyroid gland identification and blood supply detection device is characterized by comprising an incident light path, a receiving light path and a light path detection and analysis module, wherein the incident light path emits a light path to a detection target object (7), the receiving light path receives autofluorescence and reflected light of the detection target object (7), and the light path analysis module is respectively connected with the incident light path and the receiving light path;
the incident light path comprises a near infrared light source (1), a red light source (4) and an incident optical fiber (6), wherein light paths emitted by the infrared light source (1) and the red light source (4) are respectively coupled into the incident optical fiber (6);
the receiving optical path comprises a receiving optical fiber (8);
the light path detection analysis module comprises a light intensity detector and a main control circuit board (13), wherein the light intensity detector receives light transmitted by the receiving optical fiber (8), and the main control circuit board (13) is connected with the near infrared light source (1), the red light source (4) and the light intensity detector.
2. The parathyroid recognition and blood supply detection device of claim 1,
the incident optical fiber (6) guides near infrared light emitted by the near infrared light source (1) and red light emitted by the red light source (4) to the detection target object (7);
the receiving optical fiber (8) receives the self-fluorescence and the reflected light of the detection target object (7).
3. The parathyroid recognition and blood supply detection device of claim 1, wherein the incident light path further comprises a near infrared bandpass filter (3) and a first dichroic mirror (5);
the near infrared band-pass filter (3) is arranged on the light emitting side of the near infrared light source (1);
the first dichroic mirror (5) is obliquely arranged at the light emergent side of the near infrared light source (1) and the light emergent side of the red light source (4);
the incident optical fiber (6) receives light passing through and reflected by the first dichroic mirror (5).
4. The parathyroid recognition and blood supply detection device of claim 3,
a first convex lens (201) is arranged between the near infrared light source (1) and the near infrared band-pass filter (3);
a second convex lens (202) is arranged between the red light source (4) and the first dichroic mirror (5);
a third convex lens (203) is arranged between the first dichroic mirror (5) and the incident optical fiber (6).
5. Parathyroid recognition and blood supply detection device according to claim 1, characterized in that the light intensity detector comprises a first light intensity detector (11) and a second light intensity detector (12); the receiving light path also comprises a fluorescent bandpass filter (10) and a second dichroic mirror (9);
the second dichroic mirror (9) is obliquely arranged at the light outlet side of the receiving optical fiber (8);
the fluorescence band-pass filter (10) is arranged on the light-transmitting side of the second dichroic mirror (9).
6. The parathyroid recognition and blood supply detection device of claim 5,
the first light intensity detector (11) is arranged on the reflected light side of the second dichroic mirror (9), receives light reflected from the second dichroic mirror (9), and converts an optical signal into an electrical signal;
the second light intensity detector (12) is arranged on the light passing side of the fluorescent band-pass filter (10), receives light passing through the second dichroic mirror (9), and converts an optical signal into an electric signal;
a fourth convex lens (204) is arranged between the receiving optical fiber (8) and the second dichroic mirror (9);
a fifth convex lens (205) is arranged between the first light intensity detector (11) and the second dichroic mirror (9);
a sixth convex lens (206) is arranged between the fluorescent band-pass filter (10) and the second light intensity detector (12).
7. The parathyroid recognition and blood supply detection device of claim 1,
the optical path detection analysis module further comprises a display terminal (14), wherein the display terminal (14) is connected with the main control circuit board (13) and displays the fluorescence, blood oxygen and pulse data of the operation interface and parathyroid gland.
8. A method of using the parathyroid recognition and blood supply detection device of any one of claims 1-7, comprising:
the detection optical fiber is attached to a detection target object (7), the detection optical fiber comprises an incident optical fiber (6) and a receiving optical fiber (8), a main control circuit board (13) controls the near infrared light source (1) to be started, the red light source (4) to be closed, and the main control circuit board (13) receives a detection signal to judge whether the detection target object (7) is parathyroid gland tissue;
if the detection target object (7) is parathyroid gland tissue, the main control circuit board (14) controls the near infrared light source (1) and the red light source (4) to be started, the luminous power of the infrared light source (1) and the luminous power of the red light source (4) are adjusted to be matched, and the main control circuit board (13) receives the detection signal to obtain blood oxygen and pulse information of the detection target object (7).
9. The method according to claim 8, wherein in the determination of whether or not the detection target object (7) is parathyroid tissue, an optical path is guided to the detection target object (7) through the incident optical fiber (6), and autofluorescence and reflected light of the detection target object (7) are received through the receiving optical fiber (8);
the second light intensity detector (12) receives and converts the fluorescence intensity signal into a corresponding electric signal, the corresponding electric signal is transmitted to the main control circuit board (13), the main control circuit board (13) judges whether the detection target object (7) is parathyroid tissue according to a preset algorithm, and the detection information is transmitted to the display terminal (14).
10. The method according to claim 8, wherein, in the detection of parathyroid blood oxygen and pulse data,
the infrared light source (1) and the red light source (4) alternately flash at the same frequency;
two light paths are led to the detection target object (7) through the incidence optical fiber (6), and the reflected light of the detection target object (7) is received through the receiving optical fiber (8);
the first light intensity detector (11) receives and converts the fluorescence intensity signal into a corresponding electric signal, the corresponding electric signal is transmitted to the main control circuit board (13), the main control circuit board (13) obtains blood oxygen and pulse information of the detection target object (7) after processing and calculation, and the blood oxygen and pulse information is transmitted to the display terminal (14).
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