CN117120042A - 即便在高温多湿环境下也能够稳定崩解的无缝胶囊及其制造方法 - Google Patents
即便在高温多湿环境下也能够稳定崩解的无缝胶囊及其制造方法 Download PDFInfo
- Publication number
- CN117120042A CN117120042A CN202280026256.2A CN202280026256A CN117120042A CN 117120042 A CN117120042 A CN 117120042A CN 202280026256 A CN202280026256 A CN 202280026256A CN 117120042 A CN117120042 A CN 117120042A
- Authority
- CN
- China
- Prior art keywords
- capsule
- seamless capsule
- liquid
- seamless
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 262
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 42
- 239000004368 Modified starch Substances 0.000 claims abstract description 27
- 229920000881 Modified starch Polymers 0.000 claims abstract description 27
- 235000019426 modified starch Nutrition 0.000 claims abstract description 27
- 229920002148 Gellan gum Polymers 0.000 claims abstract description 24
- 239000000216 gellan gum Substances 0.000 claims abstract description 24
- 235000010492 gellan gum Nutrition 0.000 claims abstract description 24
- 239000007788 liquid Substances 0.000 claims description 71
- 239000010410 layer Substances 0.000 claims description 68
- 239000011247 coating layer Substances 0.000 claims description 37
- 239000011248 coating agent Substances 0.000 claims description 33
- 238000000576 coating method Methods 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 22
- 239000000110 cooling liquid Substances 0.000 claims description 19
- 238000006073 displacement reaction Methods 0.000 claims description 15
- 239000007888 film coating Substances 0.000 claims description 15
- 238000009501 film coating Methods 0.000 claims description 15
- 239000000796 flavoring agent Substances 0.000 claims description 13
- 235000019634 flavors Nutrition 0.000 claims description 13
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 10
- 235000016357 Mirtillo rosso Nutrition 0.000 claims description 10
- 244000078534 Vaccinium myrtillus Species 0.000 claims description 10
- 235000017606 Vaccinium vitis idaea Nutrition 0.000 claims description 10
- 244000077923 Vaccinium vitis idaea Species 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 9
- 235000010980 cellulose Nutrition 0.000 claims description 9
- 229920002678 cellulose Polymers 0.000 claims description 9
- 229940041616 menthol Drugs 0.000 claims description 9
- 240000000560 Citrus x paradisi Species 0.000 claims description 8
- 235000013399 edible fruits Nutrition 0.000 claims description 8
- 239000002826 coolant Substances 0.000 claims description 7
- 239000001254 oxidized starch Substances 0.000 claims description 7
- 235000013808 oxidized starch Nutrition 0.000 claims description 7
- 235000005979 Citrus limon Nutrition 0.000 claims description 6
- 244000131522 Citrus pyriformis Species 0.000 claims description 6
- 241000207199 Citrus Species 0.000 claims description 5
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 5
- 240000009088 Fragaria x ananassa Species 0.000 claims description 5
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 5
- 235000014749 Mentha crispa Nutrition 0.000 claims description 5
- 244000246386 Mentha pulegium Species 0.000 claims description 5
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 5
- 244000078639 Mentha spicata Species 0.000 claims description 5
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 5
- 241000220317 Rosa Species 0.000 claims description 5
- 235000017848 Rubus fruticosus Nutrition 0.000 claims description 5
- 240000007651 Rubus glaucus Species 0.000 claims description 5
- 235000011034 Rubus glaucus Nutrition 0.000 claims description 5
- 235000009122 Rubus idaeus Nutrition 0.000 claims description 5
- 244000151637 Sambucus canadensis Species 0.000 claims description 5
- 235000018735 Sambucus canadensis Nutrition 0.000 claims description 5
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims description 5
- 240000001717 Vaccinium macrocarpon Species 0.000 claims description 5
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims description 5
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 5
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims description 5
- 235000021029 blackberry Nutrition 0.000 claims description 5
- 235000007123 blue elder Nutrition 0.000 claims description 5
- 235000021014 blueberries Nutrition 0.000 claims description 5
- 235000020971 citrus fruits Nutrition 0.000 claims description 5
- 235000004634 cranberry Nutrition 0.000 claims description 5
- 235000007124 elderberry Nutrition 0.000 claims description 5
- 235000008995 european elder Nutrition 0.000 claims description 5
- 235000001050 hortel pimenta Nutrition 0.000 claims description 5
- 244000144730 Amygdalus persica Species 0.000 claims description 4
- 244000099147 Ananas comosus Species 0.000 claims description 4
- 235000007119 Ananas comosus Nutrition 0.000 claims description 4
- 235000004936 Bromus mango Nutrition 0.000 claims description 4
- 244000175448 Citrus madurensis Species 0.000 claims description 4
- 235000017317 Fortunella Nutrition 0.000 claims description 4
- 241000220225 Malus Species 0.000 claims description 4
- 235000011430 Malus pumila Nutrition 0.000 claims description 4
- 235000015103 Malus silvestris Nutrition 0.000 claims description 4
- 235000014826 Mangifera indica Nutrition 0.000 claims description 4
- 240000007228 Mangifera indica Species 0.000 claims description 4
- 240000005561 Musa balbisiana Species 0.000 claims description 4
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims description 4
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 4
- 235000002357 Ribes grossularia Nutrition 0.000 claims description 4
- 244000171263 Ribes grossularia Species 0.000 claims description 4
- 235000009184 Spondias indica Nutrition 0.000 claims description 4
- 235000011453 Vigna umbellata Nutrition 0.000 claims description 4
- 240000001417 Vigna umbellata Species 0.000 claims description 4
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 4
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 4
- 240000006365 Vitis vinifera Species 0.000 claims description 4
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 4
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims 2
- 235000001537 Ribes X gardonianum Nutrition 0.000 claims 1
- 235000001535 Ribes X utile Nutrition 0.000 claims 1
- 235000016919 Ribes petraeum Nutrition 0.000 claims 1
- 244000281247 Ribes rubrum Species 0.000 claims 1
- 235000002355 Ribes spicatum Nutrition 0.000 claims 1
- 239000002304 perfume Substances 0.000 description 20
- -1 2, 4-dimethyl-3-cyclohexenyl methyl Chemical group 0.000 description 19
- 239000003921 oil Substances 0.000 description 17
- 235000019198 oils Nutrition 0.000 description 17
- 229920002472 Starch Polymers 0.000 description 15
- 235000019698 starch Nutrition 0.000 description 14
- 239000000203 mixture Substances 0.000 description 13
- 239000008107 starch Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 8
- 239000000243 solution Substances 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 125000004432 carbon atom Chemical group C* 0.000 description 6
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 6
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 6
- 150000002576 ketones Chemical class 0.000 description 6
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 6
- DHKHKXVYLBGOIT-UHFFFAOYSA-N 1,1-Diethoxyethane Chemical compound CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 239000000194 fatty acid Substances 0.000 description 5
- 229930195729 fatty acid Natural products 0.000 description 5
- 150000004667 medium chain fatty acids Chemical class 0.000 description 5
- 238000003825 pressing Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000001797 sucrose acetate isobutyrate Substances 0.000 description 5
- 235000010983 sucrose acetate isobutyrate Nutrition 0.000 description 5
- UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 description 5
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 235000013871 bee wax Nutrition 0.000 description 4
- 239000012166 beeswax Substances 0.000 description 4
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- CATSNJVOTSVZJV-UHFFFAOYSA-N heptan-2-one Chemical compound CCCCCC(C)=O CATSNJVOTSVZJV-UHFFFAOYSA-N 0.000 description 4
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- FRISMOQHTLZZRP-UHFFFAOYSA-N nerol oxide Chemical compound CC(C)=CC1CC(C)=CCO1 FRISMOQHTLZZRP-UHFFFAOYSA-N 0.000 description 4
- ZWRUINPWMLAQRD-UHFFFAOYSA-N nonan-1-ol Chemical compound CCCCCCCCCO ZWRUINPWMLAQRD-UHFFFAOYSA-N 0.000 description 4
- XNLICIUVMPYHGG-UHFFFAOYSA-N pentan-2-one Chemical compound CCCC(C)=O XNLICIUVMPYHGG-UHFFFAOYSA-N 0.000 description 4
- 239000004014 plasticizer Substances 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical group OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 3
- 230000021736 acetylation Effects 0.000 description 3
- 238000006640 acetylation reaction Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 3
- 229930003633 citronellal Natural products 0.000 description 3
- 235000000983 citronellal Nutrition 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 238000004132 cross linking Methods 0.000 description 3
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 3
- 238000006266 etherification reaction Methods 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- HIGQPQRQIQDZMP-UHFFFAOYSA-N geranil acetate Natural products CC(C)=CCCC(C)=CCOC(C)=O HIGQPQRQIQDZMP-UHFFFAOYSA-N 0.000 description 3
- HIGQPQRQIQDZMP-DHZHZOJOSA-N geranyl acetate Chemical compound CC(C)=CCC\C(C)=C\COC(C)=O HIGQPQRQIQDZMP-DHZHZOJOSA-N 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 229940116411 terpineol Drugs 0.000 description 3
- 238000009777 vacuum freeze-drying Methods 0.000 description 3
- ULDHMXUKGWMISQ-SECBINFHSA-N (-)-carvone Chemical compound CC(=C)[C@@H]1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-SECBINFHSA-N 0.000 description 2
- GRWFGVWFFZKLTI-IUCAKERBSA-N (-)-α-pinene Chemical compound CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 2
- MBDOYVRWFFCFHM-SNAWJCMRSA-N (2E)-hexenal Chemical compound CCC\C=C\C=O MBDOYVRWFFCFHM-SNAWJCMRSA-N 0.000 description 2
- JSNRRGGBADWTMC-UHFFFAOYSA-N (6E)-7,11-dimethyl-3-methylene-1,6,10-dodecatriene Chemical compound CC(C)=CCCC(C)=CCCC(=C)C=C JSNRRGGBADWTMC-UHFFFAOYSA-N 0.000 description 2
- ZCHHRLHTBGRGOT-SNAWJCMRSA-N (E)-hex-2-en-1-ol Chemical compound CCC\C=C\CO ZCHHRLHTBGRGOT-SNAWJCMRSA-N 0.000 description 2
- HRHOWZHRCRZVCU-AATRIKPKSA-N (E)-hex-2-enyl acetate Chemical compound CCC\C=C\COC(C)=O HRHOWZHRCRZVCU-AATRIKPKSA-N 0.000 description 2
- BSAIUMLZVGUGKX-BQYQJAHWSA-N (E)-non-2-enal Chemical compound CCCCCC\C=C\C=O BSAIUMLZVGUGKX-BQYQJAHWSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 2
- ULPMRIXXHGUZFA-UHFFFAOYSA-N (R)-4-Methyl-3-hexanone Natural products CCC(C)C(=O)CC ULPMRIXXHGUZFA-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 2
- YGFGZTXGYTUXBA-UHFFFAOYSA-N (±)-2,6-dimethyl-5-heptenal Chemical compound O=CC(C)CCC=C(C)C YGFGZTXGYTUXBA-UHFFFAOYSA-N 0.000 description 2
- OHBQPCCCRFSCAX-UHFFFAOYSA-N 1,4-Dimethoxybenzene Chemical compound COC1=CC=C(OC)C=C1 OHBQPCCCRFSCAX-UHFFFAOYSA-N 0.000 description 2
- BBMCTIGTTCKYKF-UHFFFAOYSA-N 1-heptanol Chemical compound CCCCCCCO BBMCTIGTTCKYKF-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- KLIDCXVFHGNTTM-UHFFFAOYSA-N 2,6-dimethoxyphenol Chemical compound COC1=CC=CC(OC)=C1O KLIDCXVFHGNTTM-UHFFFAOYSA-N 0.000 description 2
- ZQPCOAKGRYBBMR-UHFFFAOYSA-N 2-(4-Methylcyclohex-3-en-1-yl)propane-2-thiol Chemical compound CC1=CCC(C(C)(C)S)CC1 ZQPCOAKGRYBBMR-UHFFFAOYSA-N 0.000 description 2
- PETRWTHZSKVLRE-UHFFFAOYSA-N 2-Methoxy-4-methylphenol Chemical compound COC1=CC(C)=CC=C1O PETRWTHZSKVLRE-UHFFFAOYSA-N 0.000 description 2
- CETWDUZRCINIHU-UHFFFAOYSA-N 2-heptanol Chemical compound CCCCCC(C)O CETWDUZRCINIHU-UHFFFAOYSA-N 0.000 description 2
- BYGQBDHUGHBGMD-UHFFFAOYSA-N 2-methylbutanal Chemical compound CCC(C)C=O BYGQBDHUGHBGMD-UHFFFAOYSA-N 0.000 description 2
- ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 2-octanone Chemical compound CCCCCCC(C)=O ZPVFWPFBNIEHGJ-UHFFFAOYSA-N 0.000 description 2
- JIMGVOCOYZFDKB-UHFFFAOYSA-N 2-phenylethyl 3-methylbutanoate Chemical compound CC(C)CC(=O)OCCC1=CC=CC=C1 JIMGVOCOYZFDKB-UHFFFAOYSA-N 0.000 description 2
- PFCHFHIRKBAQGU-UHFFFAOYSA-N 3-hexanone Chemical compound CCCC(=O)CC PFCHFHIRKBAQGU-UHFFFAOYSA-N 0.000 description 2
- YGHRJJRRZDOVPD-UHFFFAOYSA-N 3-methylbutanal Chemical compound CC(C)CC=O YGHRJJRRZDOVPD-UHFFFAOYSA-N 0.000 description 2
- IWTBVKIGCDZRPL-UHFFFAOYSA-N 3-methylpentanol Chemical compound CCC(C)CCO IWTBVKIGCDZRPL-UHFFFAOYSA-N 0.000 description 2
- RHLVCLIPMVJYKS-UHFFFAOYSA-N 3-octanone Chemical compound CCCCCC(=O)CC RHLVCLIPMVJYKS-UHFFFAOYSA-N 0.000 description 2
- GNKZMNRKLCTJAY-UHFFFAOYSA-N 4'-Methylacetophenone Chemical compound CC(=O)C1=CC=C(C)C=C1 GNKZMNRKLCTJAY-UHFFFAOYSA-N 0.000 description 2
- CWRKZMLUDFBPAO-SREVYHEPSA-N 4-Decenal Chemical compound CCCCC\C=C/CCC=O CWRKZMLUDFBPAO-SREVYHEPSA-N 0.000 description 2
- CHWNEIVBYREQRF-UHFFFAOYSA-N 4-Ethyl-2-methoxyphenol Chemical compound CCC1=CC=C(O)C(OC)=C1 CHWNEIVBYREQRF-UHFFFAOYSA-N 0.000 description 2
- HCFAJYNVAYBARA-UHFFFAOYSA-N 4-heptanone Chemical compound CCCC(=O)CCC HCFAJYNVAYBARA-UHFFFAOYSA-N 0.000 description 2
- NTPLXRHDUXRPNE-UHFFFAOYSA-N 4-methoxyacetophenone Chemical compound COC1=CC=C(C(C)=O)C=C1 NTPLXRHDUXRPNE-UHFFFAOYSA-N 0.000 description 2
- OALYTRUKMRCXNH-UHFFFAOYSA-N 5-pentyloxolan-2-one Chemical compound CCCCCC1CCC(=O)O1 OALYTRUKMRCXNH-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- IYTXKIXETAELAV-UHFFFAOYSA-N Aethyl-n-hexyl-keton Natural products CCCCCCC(=O)CC IYTXKIXETAELAV-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 2
- DZNVIZQPWLDQHI-UHFFFAOYSA-N Citronellyl formate Chemical compound O=COCCC(C)CCC=C(C)C DZNVIZQPWLDQHI-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- NUPSHWCALHZGOV-UHFFFAOYSA-N Decyl acetate Chemical compound CCCCCCCCCCOC(C)=O NUPSHWCALHZGOV-UHFFFAOYSA-N 0.000 description 2
- QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical compound CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 description 2
- VZWGRQBCURJOMT-UHFFFAOYSA-N Dodecyl acetate Chemical compound CCCCCCCCCCCCOC(C)=O VZWGRQBCURJOMT-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- RZKSECIXORKHQS-UHFFFAOYSA-N Heptan-3-ol Chemical compound CCCCC(O)CC RZKSECIXORKHQS-UHFFFAOYSA-N 0.000 description 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 2
- 241000721662 Juniperus Species 0.000 description 2
- 244000165082 Lavanda vera Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- BTJXBZZBBNNTOV-UHFFFAOYSA-N Linalyl benzoate Chemical compound CC(C)=CCCC(C)(C=C)OC(=O)C1=CC=CC=C1 BTJXBZZBBNNTOV-UHFFFAOYSA-N 0.000 description 2
- 235000010676 Ocimum basilicum Nutrition 0.000 description 2
- 240000007926 Ocimum gratissimum Species 0.000 description 2
- PWLNAUNEAKQYLH-UHFFFAOYSA-N Octyl butanoate Chemical compound CCCCCCCCOC(=O)CCC PWLNAUNEAKQYLH-UHFFFAOYSA-N 0.000 description 2
- BYCHQEILESTMQU-UHFFFAOYSA-N Propionsaeure-nerylester Natural products CCC(=O)OCC=C(C)CCC=C(C)C BYCHQEILESTMQU-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- MOYAFQVGZZPNRA-UHFFFAOYSA-N Terpinolene Chemical compound CC(C)=C1CCC(C)=CC1 MOYAFQVGZZPNRA-UHFFFAOYSA-N 0.000 description 2
- 238000010306 acid treatment Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 2
- IGODOXYLBBXFDW-UHFFFAOYSA-N alpha-Terpinyl acetate Chemical compound CC(=O)OC(C)(C)C1CCC(C)=CC1 IGODOXYLBBXFDW-UHFFFAOYSA-N 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 235000021028 berry Nutrition 0.000 description 2
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 2
- UAHWPYUMFXYFJY-UHFFFAOYSA-N beta-myrcene Chemical compound CC(C)=CCCC(=C)C=C UAHWPYUMFXYFJY-UHFFFAOYSA-N 0.000 description 2
- NMJJFJNHVMGPGM-UHFFFAOYSA-N butyl formate Chemical compound CCCCOC=O NMJJFJNHVMGPGM-UHFFFAOYSA-N 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- CRPUJAZIXJMDBK-UHFFFAOYSA-N camphene Chemical compound C1CC2C(=C)C(C)(C)C1C2 CRPUJAZIXJMDBK-UHFFFAOYSA-N 0.000 description 2
- BQOFWKZOCNGFEC-UHFFFAOYSA-N carene Chemical compound C1C(C)=CCC2C(C)(C)C12 BQOFWKZOCNGFEC-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 235000017803 cinnamon Nutrition 0.000 description 2
- 229940043350 citral Drugs 0.000 description 2
- WTEVQBCEXWBHNA-YFHOEESVSA-N citral B Natural products CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 description 2
- 235000000484 citronellol Nutrition 0.000 description 2
- JOZKFWLRHCDGJA-UHFFFAOYSA-N citronellol acetate Chemical compound CC(=O)OCCC(C)CCC=C(C)C JOZKFWLRHCDGJA-UHFFFAOYSA-N 0.000 description 2
- 238000013329 compounding Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 235000005687 corn oil Nutrition 0.000 description 2
- 239000002285 corn oil Substances 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 description 2
- 229930008394 dihydromyrcenol Natural products 0.000 description 2
- XSNQECSCDATQEL-UHFFFAOYSA-N dihydromyrcenol Chemical compound C=CC(C)CCCC(C)(C)O XSNQECSCDATQEL-UHFFFAOYSA-N 0.000 description 2
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
- HFJRKMMYBMWEAD-UHFFFAOYSA-N dodecanal Chemical compound CCCCCCCCCCCC=O HFJRKMMYBMWEAD-UHFFFAOYSA-N 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- OMSUIQOIVADKIM-UHFFFAOYSA-N ethyl 3-hydroxybutyrate Chemical compound CCOC(=O)CC(C)O OMSUIQOIVADKIM-UHFFFAOYSA-N 0.000 description 2
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 description 2
- RGXWDWUGBIJHDO-UHFFFAOYSA-N ethyl decanoate Chemical compound CCCCCCCCCC(=O)OCC RGXWDWUGBIJHDO-UHFFFAOYSA-N 0.000 description 2
- BYEVBITUADOIGY-UHFFFAOYSA-N ethyl nonanoate Chemical compound CCCCCCCCC(=O)OCC BYEVBITUADOIGY-UHFFFAOYSA-N 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- JBFHTYHTHYHCDJ-UHFFFAOYSA-N gamma-caprolactone Chemical compound CCC1CCC(=O)O1 JBFHTYHTHYHCDJ-UHFFFAOYSA-N 0.000 description 2
- IFYYFLINQYPWGJ-UHFFFAOYSA-N gamma-decalactone Chemical compound CCCCCCC1CCC(=O)O1 IFYYFLINQYPWGJ-UHFFFAOYSA-N 0.000 description 2
- FQMZVFJYMPNUCT-UHFFFAOYSA-N geraniol formate Natural products CC(C)=CCCC(C)=CCOC=O FQMZVFJYMPNUCT-UHFFFAOYSA-N 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- NGAZZOYFWWSOGK-UHFFFAOYSA-N heptan-3-one Chemical compound CCCCC(=O)CC NGAZZOYFWWSOGK-UHFFFAOYSA-N 0.000 description 2
- FXHGMKSSBGDXIY-UHFFFAOYSA-N heptanal Chemical compound CCCCCCC=O FXHGMKSSBGDXIY-UHFFFAOYSA-N 0.000 description 2
- JARKCYVAAOWBJS-UHFFFAOYSA-N hexanal Chemical compound CCCCCC=O JARKCYVAAOWBJS-UHFFFAOYSA-N 0.000 description 2
- MWVFCEVNXHTDNF-UHFFFAOYSA-N hexane-2,3-dione Chemical compound CCCC(=O)C(C)=O MWVFCEVNXHTDNF-UHFFFAOYSA-N 0.000 description 2
- AOGQPLXWSUTHQB-UHFFFAOYSA-N hexyl acetate Chemical compound CCCCCCOC(C)=O AOGQPLXWSUTHQB-UHFFFAOYSA-N 0.000 description 2
- 239000011229 interlayer Substances 0.000 description 2
- MLFHJEHSLIIPHL-UHFFFAOYSA-N isoamyl acetate Chemical compound CC(C)CCOC(C)=O MLFHJEHSLIIPHL-UHFFFAOYSA-N 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- 150000002596 lactones Chemical class 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 235000001510 limonene Nutrition 0.000 description 2
- 229940087305 limonene Drugs 0.000 description 2
- 229930007744 linalool Natural products 0.000 description 2
- UWKAYLJWKGQEPM-LBPRGKRZSA-N linalyl acetate Chemical compound CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- GVOWHGSUZUUUDR-UHFFFAOYSA-N methyl N-methylanthranilate Chemical compound CNC1=CC=CC=C1C(=O)OC GVOWHGSUZUUUDR-UHFFFAOYSA-N 0.000 description 2
- VAMXMNNIEUEQDV-UHFFFAOYSA-N methyl anthranilate Chemical compound COC(=O)C1=CC=CC=C1N VAMXMNNIEUEQDV-UHFFFAOYSA-N 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- IJXHLVMUNBOGRR-UHFFFAOYSA-N methyl nonanoate Chemical compound CCCCCCCCC(=O)OC IJXHLVMUNBOGRR-UHFFFAOYSA-N 0.000 description 2
- JGHZJRVDZXSNKQ-UHFFFAOYSA-N methyl octanoate Chemical compound CCCCCCCC(=O)OC JGHZJRVDZXSNKQ-UHFFFAOYSA-N 0.000 description 2
- HIGQPQRQIQDZMP-FLIBITNWSA-N neryl acetate Chemical compound CC(C)=CCC\C(C)=C/COC(C)=O HIGQPQRQIQDZMP-FLIBITNWSA-N 0.000 description 2
- VKCYHJWLYTUGCC-UHFFFAOYSA-N nonan-2-one Chemical compound CCCCCCCC(C)=O VKCYHJWLYTUGCC-UHFFFAOYSA-N 0.000 description 2
- GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 2
- GJQIMXVRFNLMTB-UHFFFAOYSA-N nonyl acetate Chemical compound CCCCCCCCCOC(C)=O GJQIMXVRFNLMTB-UHFFFAOYSA-N 0.000 description 2
- NMRPBPVERJPACX-UHFFFAOYSA-N octan-3-ol Chemical compound CCCCCC(O)CC NMRPBPVERJPACX-UHFFFAOYSA-N 0.000 description 2
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 2
- YLYBTZIQSIBWLI-UHFFFAOYSA-N octyl acetate Chemical compound CCCCCCCCOC(C)=O YLYBTZIQSIBWLI-UHFFFAOYSA-N 0.000 description 2
- HFPZCAJZSCWRBC-UHFFFAOYSA-N p-cymene Chemical compound CC(C)C1=CC=C(C)C=C1 HFPZCAJZSCWRBC-UHFFFAOYSA-N 0.000 description 2
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 2
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N pentanal Chemical compound CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- DTUQWGWMVIHBKE-UHFFFAOYSA-N phenylacetaldehyde Chemical compound O=CCC1=CC=CC=C1 DTUQWGWMVIHBKE-UHFFFAOYSA-N 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- CZCBTSFUTPZVKJ-UHFFFAOYSA-N rose oxide Chemical compound CC1CCOC(C=C(C)C)C1 CZCBTSFUTPZVKJ-UHFFFAOYSA-N 0.000 description 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 2
- 239000007901 soft capsule Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 235000013555 soy sauce Nutrition 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- XJPBRODHZKDRCB-UHFFFAOYSA-N trans-alpha-ocimene Natural products CC(=C)CCC=C(C)C=C XJPBRODHZKDRCB-UHFFFAOYSA-N 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- BGEHHAVMRVXCGR-UHFFFAOYSA-N tridecanal Chemical compound CCCCCCCCCCCCC=O BGEHHAVMRVXCGR-UHFFFAOYSA-N 0.000 description 2
- XMUJIPOFTAHSOK-UHFFFAOYSA-N undecan-2-ol Chemical compound CCCCCCCCCC(C)O XMUJIPOFTAHSOK-UHFFFAOYSA-N 0.000 description 2
- KYWIYKKSMDLRDC-UHFFFAOYSA-N undecan-2-one Chemical compound CCCCCCCCCC(C)=O KYWIYKKSMDLRDC-UHFFFAOYSA-N 0.000 description 2
- KMPQYAYAQWNLME-UHFFFAOYSA-N undecanal Chemical compound CCCCCCCCCCC=O KMPQYAYAQWNLME-UHFFFAOYSA-N 0.000 description 2
- KJIOQYGWTQBHNH-UHFFFAOYSA-N undecanol Chemical compound CCCCCCCCCCCO KJIOQYGWTQBHNH-UHFFFAOYSA-N 0.000 description 2
- ZENOXNGFMSCLLL-UHFFFAOYSA-N vanillyl alcohol Chemical compound COC1=CC(CO)=CC=C1O ZENOXNGFMSCLLL-UHFFFAOYSA-N 0.000 description 2
- ABDKAPXRBAPSQN-UHFFFAOYSA-N veratrole Chemical compound COC1=CC=CC=C1OC ABDKAPXRBAPSQN-UHFFFAOYSA-N 0.000 description 2
- PHXATPHONSXBIL-UHFFFAOYSA-N xi-gamma-Undecalactone Chemical compound CCCCCCCC1CCC(=O)O1 PHXATPHONSXBIL-UHFFFAOYSA-N 0.000 description 2
- OGLDWXZKYODSOB-UHFFFAOYSA-N α-phellandrene Chemical compound CC(C)C1CC=C(C)C=C1 OGLDWXZKYODSOB-UHFFFAOYSA-N 0.000 description 2
- PSQYTAPXSHCGMF-BQYQJAHWSA-N β-ionone Chemical compound CC(=O)\C=C\C1=C(C)CCCC1(C)C PSQYTAPXSHCGMF-BQYQJAHWSA-N 0.000 description 2
- SFEOKXHPFMOVRM-UHFFFAOYSA-N (+)-(S)-gamma-ionone Natural products CC(=O)C=CC1C(=C)CCCC1(C)C SFEOKXHPFMOVRM-UHFFFAOYSA-N 0.000 description 1
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 1
- QEBNYNLSCGVZOH-NFAWXSAZSA-N (+)-valencene Chemical compound C1C[C@@H](C(C)=C)C[C@@]2(C)[C@H](C)CCC=C21 QEBNYNLSCGVZOH-NFAWXSAZSA-N 0.000 description 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 description 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 description 1
- DTGKSKDOIYIVQL-MRTMQBJTSA-N (-)-isoborneol Chemical compound C1C[C@@]2(C)[C@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-MRTMQBJTSA-N 0.000 description 1
- DCXXKSXLKWAZNO-UHFFFAOYSA-N (2-methyl-6-methylideneoct-7-en-2-yl) acetate Chemical compound CC(=O)OC(C)(C)CCCC(=C)C=C DCXXKSXLKWAZNO-UHFFFAOYSA-N 0.000 description 1
- FINOAUDUYKVGDS-UHFFFAOYSA-N (2-tert-butylcyclohexyl) acetate Chemical compound CC(=O)OC1CCCCC1C(C)(C)C FINOAUDUYKVGDS-UHFFFAOYSA-N 0.000 description 1
- 239000001112 (2E)-1,1-diethoxy-3,7-dimethylocta-2,6-diene Substances 0.000 description 1
- MMFCJPPRCYDLLZ-CMDGGOBGSA-N (2E)-dec-2-enal Chemical compound CCCCCCC\C=C\C=O MMFCJPPRCYDLLZ-CMDGGOBGSA-N 0.000 description 1
- 239000001893 (2R)-2-methylbutanal Substances 0.000 description 1
- 239000001890 (2R)-8,8,8a-trimethyl-2-prop-1-en-2-yl-1,2,3,4,6,7-hexahydronaphthalene Substances 0.000 description 1
- HLCSDJLATUNSSI-JXMROGBWSA-N (2e)-3,7-dimethylocta-2,6-dienenitrile Chemical compound CC(C)=CCC\C(C)=C\C#N HLCSDJLATUNSSI-JXMROGBWSA-N 0.000 description 1
- CXENHBSYCFFKJS-UHFFFAOYSA-N (3E,6E)-3,7,11-Trimethyl-1,3,6,10-dodecatetraene Natural products CC(C)=CCCC(C)=CCC=C(C)C=C CXENHBSYCFFKJS-UHFFFAOYSA-N 0.000 description 1
- 239000001618 (3R)-3-methylpentan-1-ol Substances 0.000 description 1
- MTDAKBBUYMYKAR-SNVBAGLBSA-N (3r)-3,7-dimethyloct-6-enenitrile Chemical compound N#CC[C@H](C)CCC=C(C)C MTDAKBBUYMYKAR-SNVBAGLBSA-N 0.000 description 1
- 229940098795 (3z)- 3-hexenyl acetate Drugs 0.000 description 1
- NGSZDVVHIGAMOJ-YHYXMXQVSA-N (3z)-3-propylidene-2-benzofuran-1-one Chemical compound C1=CC=C2C(=C/CC)/OC(=O)C2=C1 NGSZDVVHIGAMOJ-YHYXMXQVSA-N 0.000 description 1
- GQVMHMFBVWSSPF-SOYUKNQTSA-N (4E,6E)-2,6-dimethylocta-2,4,6-triene Chemical compound C\C=C(/C)\C=C\C=C(C)C GQVMHMFBVWSSPF-SOYUKNQTSA-N 0.000 description 1
- CCEFMUBVSUDRLG-KXUCPTDWSA-N (4R)-limonene 1,2-epoxide Natural products C1[C@H](C(=C)C)CC[C@@]2(C)O[C@H]21 CCEFMUBVSUDRLG-KXUCPTDWSA-N 0.000 description 1
- MMLYERLRGHVBEK-XYOKQWHBSA-N (4e)-5,9-dimethyldeca-4,8-dienal Chemical compound CC(C)=CCC\C(C)=C\CCC=O MMLYERLRGHVBEK-XYOKQWHBSA-N 0.000 description 1
- 239000001371 (5E)-3,5-dimethylocta-1,5,7-trien-3-ol Substances 0.000 description 1
- DTCCTIQRPGSLPT-ONEGZZNKSA-N (E)-2-pentenal Chemical compound CC\C=C\C=O DTCCTIQRPGSLPT-ONEGZZNKSA-N 0.000 description 1
- 239000001211 (E)-4-phenylbut-3-en-2-one Substances 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- SSNZFFBDIMUILS-ZHACJKMWSA-N (E)-dodec-2-enal Chemical compound CCCCCCCCC\C=C\C=O SSNZFFBDIMUILS-ZHACJKMWSA-N 0.000 description 1
- FQMZVFJYMPNUCT-YRNVUSSQSA-N (E)-geranyl formate Chemical compound CC(C)=CCC\C(C)=C\COC=O FQMZVFJYMPNUCT-YRNVUSSQSA-N 0.000 description 1
- NDFKTBCGKNOHPJ-AATRIKPKSA-N (E)-hept-2-enal Chemical compound CCCC\C=C\C=O NDFKTBCGKNOHPJ-AATRIKPKSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- JGMYDQCXGIMHLL-WAYWQWQTSA-N (Z)-hexadec-11-enoic acid Chemical compound CCCC\C=C/CCCCCCCCCC(O)=O JGMYDQCXGIMHLL-WAYWQWQTSA-N 0.000 description 1
- FETSKTIMHFKZNF-AATRIKPKSA-N (e)-4-(2,4,6-trimethylcyclohex-3-en-1-yl)but-3-en-2-one Chemical compound CC1CC(C)=CC(C)C1\C=C\C(C)=O FETSKTIMHFKZNF-AATRIKPKSA-N 0.000 description 1
- VTIODUHBZHNXFP-IHWYPQMZSA-N (e)-4-hexen-1-ol Chemical compound C\C=C/CCCO VTIODUHBZHNXFP-IHWYPQMZSA-N 0.000 description 1
- CWRKZMLUDFBPAO-VOTSOKGWSA-N (e)-dec-4-enal Chemical compound CCCCC\C=C\CCC=O CWRKZMLUDFBPAO-VOTSOKGWSA-N 0.000 description 1
- HBBONAOKVLYWBI-MDZDMXLPSA-N (e)-dodec-3-enal Chemical compound CCCCCCCC\C=C\CC=O HBBONAOKVLYWBI-MDZDMXLPSA-N 0.000 description 1
- IOBHVJHSBREPFR-FPLPWBNLSA-N (z)-1,1-diethoxyhex-3-ene Chemical compound CCOC(OCC)C\C=C/CC IOBHVJHSBREPFR-FPLPWBNLSA-N 0.000 description 1
- NTXGFKWLJFHGGJ-ACCUITESSA-N 1,1-Diethoxy-3,7-dimethyl-2,6-octadiene Chemical compound CCOC(OCC)\C=C(/C)CCC=C(C)C NTXGFKWLJFHGGJ-ACCUITESSA-N 0.000 description 1
- LYLVOCPDQAOQKL-UHFFFAOYSA-N 1,1-Dimethoxynonane Chemical compound CCCCCCCCC(OC)OC LYLVOCPDQAOQKL-UHFFFAOYSA-N 0.000 description 1
- BZOOCKAFKVYAOZ-UHFFFAOYSA-N 1,1-Dimethoxyoctane Chemical compound CCCCCCCC(OC)OC BZOOCKAFKVYAOZ-UHFFFAOYSA-N 0.000 description 1
- GDDPLWAEEWIQKZ-UHFFFAOYSA-N 1,1-diethoxydecane Chemical compound CCCCCCCCCC(OCC)OCC GDDPLWAEEWIQKZ-UHFFFAOYSA-N 0.000 description 1
- UGOCNHASEZIJFQ-UHFFFAOYSA-N 1,1-diethoxyheptane Chemical compound CCCCCCC(OCC)OCC UGOCNHASEZIJFQ-UHFFFAOYSA-N 0.000 description 1
- WMQKYHTZGYIHHD-UHFFFAOYSA-N 1,1-diethoxyhex-2-ene Chemical compound CCCC=CC(OCC)OCC WMQKYHTZGYIHHD-UHFFFAOYSA-N 0.000 description 1
- NJXYRZMLVYMJHM-UHFFFAOYSA-N 1,1-dimethoxy-2-methylundecane Chemical compound CCCCCCCCCC(C)C(OC)OC NJXYRZMLVYMJHM-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- FXCYGAGBPZQRJE-ZHACJKMWSA-N 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1,6-heptadien-3-one Chemical compound CC1=CCCC(C)(C)C1\C=C\C(=O)CCC=C FXCYGAGBPZQRJE-ZHACJKMWSA-N 0.000 description 1
- VPKMGDRERYMTJX-CMDGGOBGSA-N 1-(2,6,6-Trimethyl-2-cyclohexen-1-yl)-1-penten-3-one Chemical compound CCC(=O)\C=C\C1C(C)=CCCC1(C)C VPKMGDRERYMTJX-CMDGGOBGSA-N 0.000 description 1
- ANLABNUUYWRCRP-UHFFFAOYSA-N 1-(4-nitrophenyl)cyclopentane-1-carbonitrile Chemical compound C1=CC([N+](=O)[O-])=CC=C1C1(C#N)CCCC1 ANLABNUUYWRCRP-UHFFFAOYSA-N 0.000 description 1
- 239000005968 1-Decanol Substances 0.000 description 1
- NSOAQRMLVFRWIT-UHFFFAOYSA-N 1-ethenoxydecane Chemical compound CCCCCCCCCCOC=C NSOAQRMLVFRWIT-UHFFFAOYSA-N 0.000 description 1
- AOSKXPFBGRLCEG-GQCTYLIASA-N 1-ethoxy-2-methoxy-4-[(e)-prop-1-enyl]benzene Chemical compound CCOC1=CC=C(\C=C\C)C=C1OC AOSKXPFBGRLCEG-GQCTYLIASA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- XBGUIVFBMBVUEG-UHFFFAOYSA-N 1-methyl-4-(1,5-dimethyl-4-hexenylidene)-1-cyclohexene Chemical compound CC(C)=CCCC(C)=C1CCC(C)=CC1 XBGUIVFBMBVUEG-UHFFFAOYSA-N 0.000 description 1
- MVTYXAVPKZRAMW-UHFFFAOYSA-N 1-methyl-4-(4-methylpentyl)cyclohex-3-ene-1-carbaldehyde Chemical compound CC(C)CCCC1=CCC(C)(C=O)CC1 MVTYXAVPKZRAMW-UHFFFAOYSA-N 0.000 description 1
- QQLIGMASAVJVON-UHFFFAOYSA-N 1-naphthalen-1-ylethanone Chemical compound C1=CC=C2C(C(=O)C)=CC=CC2=C1 QQLIGMASAVJVON-UHFFFAOYSA-N 0.000 description 1
- WAPNOHKVXSQRPX-UHFFFAOYSA-N 1-phenylethanol Chemical compound CC(O)C1=CC=CC=C1 WAPNOHKVXSQRPX-UHFFFAOYSA-N 0.000 description 1
- GIEMHYCMBGELGY-UHFFFAOYSA-N 10-undecen-1-ol Chemical compound OCCCCCCCCCC=C GIEMHYCMBGELGY-UHFFFAOYSA-N 0.000 description 1
- OFHHDSQXFXLTKC-UHFFFAOYSA-N 10-undecenal Chemical compound C=CCCCCCCCCC=O OFHHDSQXFXLTKC-UHFFFAOYSA-N 0.000 description 1
- WNJSKZBEWNVKGU-UHFFFAOYSA-N 2,2-dimethoxyethylbenzene Chemical compound COC(OC)CC1=CC=CC=C1 WNJSKZBEWNVKGU-UHFFFAOYSA-N 0.000 description 1
- KVGYAHNHKCCHSP-UHFFFAOYSA-N 2,2-dimethyloctanal Chemical compound CCCCCCC(C)(C)C=O KVGYAHNHKCCHSP-UHFFFAOYSA-N 0.000 description 1
- XKGZDWNQGLJWLP-UHFFFAOYSA-N 2,3,3-trimethyl-2-pentylcyclopentan-1-one Chemical compound CCCCCC1(C)C(=O)CCC1(C)C XKGZDWNQGLJWLP-UHFFFAOYSA-N 0.000 description 1
- 229940029225 2,6-dimethyl-5-heptenal Drugs 0.000 description 1
- RCYIBFNZRWQGNB-UHFFFAOYSA-N 2,6-dimethylheptan-1-ol Chemical compound CC(C)CCCC(C)CO RCYIBFNZRWQGNB-UHFFFAOYSA-N 0.000 description 1
- BEARMGATPGLSKG-UHFFFAOYSA-N 2,6-dimethyloct-7-en-2-yl acetate Chemical compound C=CC(C)CCCC(C)(C)OC(C)=O BEARMGATPGLSKG-UHFFFAOYSA-N 0.000 description 1
- WRFXXJKURVTLSY-UHFFFAOYSA-N 2,6-dimethyloctan-2-ol Chemical compound CCC(C)CCCC(C)(C)O WRFXXJKURVTLSY-UHFFFAOYSA-N 0.000 description 1
- XOHIHZHSDMWWMS-UHFFFAOYSA-N 2-(2-Methylpropoxy)naphthalene Chemical compound C1=CC=CC2=CC(OCC(C)C)=CC=C21 XOHIHZHSDMWWMS-UHFFFAOYSA-N 0.000 description 1
- VVUMWAHNKOLVSN-UHFFFAOYSA-N 2-(4-ethoxyanilino)-n-propylpropanamide Chemical compound CCCNC(=O)C(C)NC1=CC=C(OCC)C=C1 VVUMWAHNKOLVSN-UHFFFAOYSA-N 0.000 description 1
- FSKGFRBHGXIDSA-UHFFFAOYSA-N 2-(4-propan-2-ylphenyl)acetaldehyde Chemical compound CC(C)C1=CC=C(CC=O)C=C1 FSKGFRBHGXIDSA-UHFFFAOYSA-N 0.000 description 1
- 239000001278 2-(5-ethenyl-5-methyloxolan-2-yl)propan-2-ol Substances 0.000 description 1
- AWNOGHRWORTNEI-UHFFFAOYSA-N 2-(6,6-dimethyl-4-bicyclo[3.1.1]hept-3-enyl)ethyl acetate Chemical compound CC(=O)OCCC1=CCC2C(C)(C)C1C2 AWNOGHRWORTNEI-UHFFFAOYSA-N 0.000 description 1
- GUMOJENFFHZAFP-UHFFFAOYSA-N 2-Ethoxynaphthalene Chemical compound C1=CC=CC2=CC(OCC)=CC=C21 GUMOJENFFHZAFP-UHFFFAOYSA-N 0.000 description 1
- LUZDYPLAQQGJEA-UHFFFAOYSA-N 2-Methoxynaphthalene Chemical compound C1=CC=CC2=CC(OC)=CC=C21 LUZDYPLAQQGJEA-UHFFFAOYSA-N 0.000 description 1
- HIGGFWFRAWSMBR-UHFFFAOYSA-N 2-Methyl-3-hexanone Chemical compound CCCC(=O)C(C)C HIGGFWFRAWSMBR-UHFFFAOYSA-N 0.000 description 1
- ZKPFRIDJMMOODR-UHFFFAOYSA-N 2-Methyloctanal Chemical compound CCCCCCC(C)C=O ZKPFRIDJMMOODR-UHFFFAOYSA-N 0.000 description 1
- PXWNBAGCFUDYBE-UHFFFAOYSA-N 2-Phenylethyl 2-aminobenzoate Chemical compound NC1=CC=CC=C1C(=O)OCCC1=CC=CC=C1 PXWNBAGCFUDYBE-UHFFFAOYSA-N 0.000 description 1
- CWZGKTMWPFTJCS-UHFFFAOYSA-N 2-cyclopentylcyclopentan-1-one Chemical compound O=C1CCCC1C1CCCC1 CWZGKTMWPFTJCS-UHFFFAOYSA-N 0.000 description 1
- DVCHJFSLGUNEQZ-UHFFFAOYSA-M 2-ethenyl-2,6-dimethylhept-5-enoate Chemical compound CC(C)=CCCC(C)(C=C)C([O-])=O DVCHJFSLGUNEQZ-UHFFFAOYSA-M 0.000 description 1
- WQAPNRUAKQGQLB-UHFFFAOYSA-N 2-methoxy-4-[(oxiran-2-yl)methyl]phenol Chemical compound C1=C(O)C(OC)=CC(CC2OC2)=C1 WQAPNRUAKQGQLB-UHFFFAOYSA-N 0.000 description 1
- SGVBCLGVIOFAFT-UHFFFAOYSA-N 2-methyl-3-(4-methylphenyl)propanal Chemical compound O=CC(C)CC1=CC=C(C)C=C1 SGVBCLGVIOFAFT-UHFFFAOYSA-N 0.000 description 1
- LBICMZLDYMBIGA-UHFFFAOYSA-N 2-methyldecanal Chemical compound CCCCCCCCC(C)C=O LBICMZLDYMBIGA-UHFFFAOYSA-N 0.000 description 1
- JMMZCWZIJXAGKW-UHFFFAOYSA-N 2-methylpent-2-ene Chemical compound CCC=C(C)C JMMZCWZIJXAGKW-UHFFFAOYSA-N 0.000 description 1
- OVBFMEVBMNZIBR-UHFFFAOYSA-M 2-methylvalerate Chemical compound CCCC(C)C([O-])=O OVBFMEVBMNZIBR-UHFFFAOYSA-M 0.000 description 1
- ILHZVKAXFCDFMT-UHFFFAOYSA-N 2-pentylcyclopent-2-en-1-one Chemical compound CCCCCC1=CCCC1=O ILHZVKAXFCDFMT-UHFFFAOYSA-N 0.000 description 1
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 1
- GNTQOKGIVMJHQG-UHFFFAOYSA-N 2-propan-2-yloxypyridine-3-carbaldehyde Chemical compound CC(C)OC1=NC=CC=C1C=O GNTQOKGIVMJHQG-UHFFFAOYSA-N 0.000 description 1
- ALVJDUNBMKMTDC-UHFFFAOYSA-N 2-tert-butyl-1,4-dimethoxybenzene Chemical compound COC1=CC=C(OC)C(C(C)(C)C)=C1 ALVJDUNBMKMTDC-UHFFFAOYSA-N 0.000 description 1
- VMUNAKQXJLHODT-VAWYXSNFSA-N 2-tridecenal Chemical compound CCCCCCCCCC\C=C\C=O VMUNAKQXJLHODT-VAWYXSNFSA-N 0.000 description 1
- VMUNAKQXJLHODT-UHFFFAOYSA-N 2E-tridecenal Natural products CCCCCCCCCCC=CC=O VMUNAKQXJLHODT-UHFFFAOYSA-N 0.000 description 1
- VKPRTBDRPNWOGL-UHFFFAOYSA-N 3,4,4a,5,8,8a-hexahydro-3',7-dimethyl-spiro(1,4-methanonaphthalene-2(1h),2'-oxirane) Chemical compound CC1OC11C(C2C3CC=C(C)C2)CC3C1 VKPRTBDRPNWOGL-UHFFFAOYSA-N 0.000 description 1
- YGCXQTYRSKMILM-UHFFFAOYSA-N 3,4-diaminobenzohydrazide Chemical compound NNC(=O)C1=CC=C(N)C(N)=C1 YGCXQTYRSKMILM-UHFFFAOYSA-N 0.000 description 1
- VMUXSMXIQBNMGZ-UHFFFAOYSA-N 3,4-dihydrocoumarin Chemical compound C1=CC=C2OC(=O)CCC2=C1 VMUXSMXIQBNMGZ-UHFFFAOYSA-N 0.000 description 1
- YXRXDZOBKUTUQZ-UHFFFAOYSA-N 3,4-dimethyloct-3-en-2-one Chemical compound CCCCC(C)=C(C)C(C)=O YXRXDZOBKUTUQZ-UHFFFAOYSA-N 0.000 description 1
- WTPYRCJDOZVZON-UHFFFAOYSA-N 3,5,5-Trimethylhexanal Chemical compound O=CCC(C)CC(C)(C)C WTPYRCJDOZVZON-UHFFFAOYSA-N 0.000 description 1
- FAGYGFPZNTYLAO-UHFFFAOYSA-N 3,7-dimethyl-2-methylideneoct-6-enal Chemical compound O=CC(=C)C(C)CCC=C(C)C FAGYGFPZNTYLAO-UHFFFAOYSA-N 0.000 description 1
- DLHQZZUEERVIGQ-UHFFFAOYSA-N 3,7-dimethyl-3-octanol Chemical compound CCC(C)(O)CCCC(C)C DLHQZZUEERVIGQ-UHFFFAOYSA-N 0.000 description 1
- DHJVLXVXNFUSMU-UHFFFAOYSA-N 3,7-dimethylnona-2,6-dienenitrile Chemical compound CCC(C)=CCCC(C)=CC#N DHJVLXVXNFUSMU-UHFFFAOYSA-N 0.000 description 1
- JRTBBCBDKSRRCY-UHFFFAOYSA-N 3,7-dimethyloct-6-en-3-ol Chemical compound CCC(C)(O)CCC=C(C)C JRTBBCBDKSRRCY-UHFFFAOYSA-N 0.000 description 1
- PRNCMAKCNVRZFX-UHFFFAOYSA-N 3,7-dimethyloctan-1-ol Chemical compound CC(C)CCCC(C)CCO PRNCMAKCNVRZFX-UHFFFAOYSA-N 0.000 description 1
- GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 1
- NMRPBPVERJPACX-QMMMGPOBSA-N 3-Octanol Natural products CCCCC[C@@H](O)CC NMRPBPVERJPACX-QMMMGPOBSA-N 0.000 description 1
- YCIXWYOBMVNGTB-UHFFFAOYSA-N 3-methyl-2-pentylcyclopent-2-en-1-one Chemical compound CCCCCC1=C(C)CCC1=O YCIXWYOBMVNGTB-UHFFFAOYSA-N 0.000 description 1
- 239000001374 3-phenylprop-2-enyl 2-aminobenzoate Substances 0.000 description 1
- YGCZTXZTJXYWCO-UHFFFAOYSA-N 3-phenylpropanal Chemical compound O=CCCC1=CC=CC=C1 YGCZTXZTJXYWCO-UHFFFAOYSA-N 0.000 description 1
- VWFXPROOUAWFEE-UHFFFAOYSA-N 41724-19-0 Chemical compound C12CC(=O)C(C)CC2C2CC1CC2 VWFXPROOUAWFEE-UHFFFAOYSA-N 0.000 description 1
- RIAHASMJDOMQER-UHFFFAOYSA-N 5-ethyl-2-methyl-1h-imidazole Chemical compound CCC1=CN=C(C)N1 RIAHASMJDOMQER-UHFFFAOYSA-N 0.000 description 1
- KMRMUZKLFIEVAO-UHFFFAOYSA-N 7,7-dimethylbicyclo[3.1.1]hept-3-ene-4-carbaldehyde Chemical compound C1C2C(C)(C)C1CC=C2C=O KMRMUZKLFIEVAO-UHFFFAOYSA-N 0.000 description 1
- QCJVKUULZGKQDG-UHFFFAOYSA-N 8,8-Dimethoxy-2,6-dimethyl-2-octanol Chemical compound COC(OC)CC(C)CCCC(C)(C)O QCJVKUULZGKQDG-UHFFFAOYSA-N 0.000 description 1
- RVOKNSFEAOYULQ-UHFFFAOYSA-N 8-Mercapto-p-menthan-3-one Chemical compound CC1CCC(C(C)(C)S)C(=O)C1 RVOKNSFEAOYULQ-UHFFFAOYSA-N 0.000 description 1
- YNMZZHPSYMOGCI-UHFFFAOYSA-N Aethyl-octyl-keton Natural products CCCCCCCCC(=O)CC YNMZZHPSYMOGCI-UHFFFAOYSA-N 0.000 description 1
- 241000717739 Boswellia sacra Species 0.000 description 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
- JPADXNMMLQEPCG-UHFFFAOYSA-N C(CCCCCC)C1C(CCC1)=O.C(CCCCC)C1C(CCC1)=O Chemical compound C(CCCCCC)C1C(CCC1)=O.C(CCCCC)C1C(CCC1)=O JPADXNMMLQEPCG-UHFFFAOYSA-N 0.000 description 1
- GKSOMMKOEYEWAA-UHFFFAOYSA-N CC(CCCCC=CC=CC=O)(C)C Chemical compound CC(CCCCC=CC=CC=O)(C)C GKSOMMKOEYEWAA-UHFFFAOYSA-N 0.000 description 1
- XDNPHSVYYLKVAX-UHFFFAOYSA-N CCCCCCCC=CC(C)=C(C)OC(C)=O Chemical compound CCCCCCCC=CC(C)=C(C)OC(C)=O XDNPHSVYYLKVAX-UHFFFAOYSA-N 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 240000003538 Chamaemelum nobile Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- GABQNAFEZZDSCM-RMKNXTFCSA-N Cinnamyl anthranilate Chemical compound NC1=CC=CC=C1C(=O)OC\C=C\C1=CC=CC=C1 GABQNAFEZZDSCM-RMKNXTFCSA-N 0.000 description 1
- DWZRENGNFQNWQZ-DHZHZOJOSA-N Citral propylene glycol acetal Chemical compound CC1COC(\C=C(/C)CCC=C(C)C)O1 DWZRENGNFQNWQZ-DHZHZOJOSA-N 0.000 description 1
- JOZKFWLRHCDGJA-LLVKDONJSA-N Citronellyl acetate Natural products CC(=O)OCC[C@H](C)CCC=C(C)C JOZKFWLRHCDGJA-LLVKDONJSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 244000183685 Citrus aurantium Species 0.000 description 1
- 235000007716 Citrus aurantium Nutrition 0.000 description 1
- 241000555678 Citrus unshiu Species 0.000 description 1
- 240000007311 Commiphora myrrha Species 0.000 description 1
- 235000006965 Commiphora myrrha Nutrition 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- 240000004784 Cymbopogon citratus Species 0.000 description 1
- 235000017897 Cymbopogon citratus Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Chemical group CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
- RZTOWFMDBDPERY-UHFFFAOYSA-N Delta-Hexanolactone Chemical compound CC1CCCC(=O)O1 RZTOWFMDBDPERY-UHFFFAOYSA-N 0.000 description 1
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 239000005698 Dodecyl acetate Substances 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- TWLLPUMZVVGILS-UHFFFAOYSA-N Ethyl 2-aminobenzoate Chemical compound CCOC(=O)C1=CC=CC=C1N TWLLPUMZVVGILS-UHFFFAOYSA-N 0.000 description 1
- XDWQYMXQMNUWID-UHFFFAOYSA-N Ethyl 2-benzylacetoacetate Chemical compound CCOC(=O)C(C(C)=O)CC1=CC=CC=C1 XDWQYMXQMNUWID-UHFFFAOYSA-N 0.000 description 1
- WBSWYVBUGLBCOV-UHFFFAOYSA-N Ethyl N-methylanthranilate Chemical compound CCOC(=O)C1=CC=CC=C1NC WBSWYVBUGLBCOV-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 239000004863 Frankincense Substances 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Chemical group O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 241000208152 Geranium Species 0.000 description 1
- GFNFPBSXMBRHRU-UHFFFAOYSA-N Heptanal propyleneglycol acetal Chemical compound CCCCCCC1OCC(C)O1 GFNFPBSXMBRHRU-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000005867 Iprodione Substances 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- WVRPFQGZHKZCEB-UHFFFAOYSA-N Isopropyl 2-methylpropanoate Chemical compound CC(C)OC(=O)C(C)C WVRPFQGZHKZCEB-UHFFFAOYSA-N 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- XMLSXPIVAXONDL-PLNGDYQASA-N Jasmone Chemical compound CC\C=C/CC1=C(C)CCC1=O XMLSXPIVAXONDL-PLNGDYQASA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical group C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Chemical group CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 241000830535 Ligustrum lucidum Species 0.000 description 1
- CCEFMUBVSUDRLG-XNWIYYODSA-N Limonene-1,2-epoxide Chemical compound C1[C@H](C(=C)C)CCC2(C)OC21 CCEFMUBVSUDRLG-XNWIYYODSA-N 0.000 description 1
- OJKMRECJBIPPRG-UHFFFAOYSA-N Linalyl caprylate Chemical compound CCCCCCCC(=O)OC(C)(C=C)CCC=C(C)C OJKMRECJBIPPRG-UHFFFAOYSA-N 0.000 description 1
- BRHDDEIRQPDPMG-UHFFFAOYSA-N Linalyl oxide Chemical compound CC(C)(O)C1CCC(C)(C=C)O1 BRHDDEIRQPDPMG-UHFFFAOYSA-N 0.000 description 1
- JBVVONYMRFACPQ-UHFFFAOYSA-N Linalylformate Natural products CC(=C)CCCC(C)(OC=O)C=C JBVVONYMRFACPQ-UHFFFAOYSA-N 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 240000003183 Manihot esculenta Species 0.000 description 1
- 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 1
- ACCRBMDJCPPJDX-UHFFFAOYSA-N Methyl 3-hydroxyhexanoate Chemical compound CCCC(O)CC(=O)OC ACCRBMDJCPPJDX-UHFFFAOYSA-N 0.000 description 1
- ICBJCVRQDSQPGI-UHFFFAOYSA-N Methyl hexyl ether Chemical compound CCCCCCOC ICBJCVRQDSQPGI-UHFFFAOYSA-N 0.000 description 1
- 239000005641 Methyl octanoate Substances 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 244000179970 Monarda didyma Species 0.000 description 1
- 235000010672 Monarda didyma Nutrition 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- KMRMUZKLFIEVAO-RKDXNWHRSA-N Myrtenal Natural products C1[C@H]2C(C)(C)[C@@H]1CC=C2C=O KMRMUZKLFIEVAO-RKDXNWHRSA-N 0.000 description 1
- 241000606266 Nardostachys Species 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- ZSBOMYJPSRFZAL-RAXLEYEMSA-N Neryl butyrate Chemical compound CCCC(=O)OC\C=C(\C)CCC=C(C)C ZSBOMYJPSRFZAL-RAXLEYEMSA-N 0.000 description 1
- DJNTZVRUYMHBTD-UHFFFAOYSA-N Octyl octanoate Chemical compound CCCCCCCCOC(=O)CCCCCCC DJNTZVRUYMHBTD-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- PXRCIOIWVGAZEP-UHFFFAOYSA-N Primaeres Camphenhydrat Natural products C1CC2C(O)(C)C(C)(C)C1C2 PXRCIOIWVGAZEP-UHFFFAOYSA-N 0.000 description 1
- RKDOXCGYGLYOBV-BNFZFUHLSA-N Propyl 2,4-decadienoate Chemical compound CCCCC\C=C\C=C\C(=O)OCCC RKDOXCGYGLYOBV-BNFZFUHLSA-N 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 240000000513 Santalum album Species 0.000 description 1
- 235000008632 Santalum album Nutrition 0.000 description 1
- 241000790234 Sphingomonas elodea Species 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- XIGFNCYVSHOLIF-UHFFFAOYSA-N Tetrahydro-5-isopropenyl-2-methyl-2-vinylfuran Chemical compound CC(=C)C1CCC(C)(C=C)O1 XIGFNCYVSHOLIF-UHFFFAOYSA-N 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 240000006909 Tilia x europaea Species 0.000 description 1
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 244000263375 Vanilla tahitensis Species 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- 235000007769 Vetiveria zizanioides Nutrition 0.000 description 1
- 244000284012 Vetiveria zizanioides Species 0.000 description 1
- YZYPQKZWNXANRB-UXBLZVDNSA-N [(e)-3-phenylprop-2-enyl] butanoate Chemical compound CCCC(=O)OC\C=C\C1=CC=CC=C1 YZYPQKZWNXANRB-UXBLZVDNSA-N 0.000 description 1
- IKHGUXGNUITLKF-XPULMUKRSA-N acetaldehyde Chemical compound [14CH]([14CH3])=O IKHGUXGNUITLKF-XPULMUKRSA-N 0.000 description 1
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N acetaldehyde dimethyl acetal Natural products COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 1
- 150000001241 acetals Chemical class 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical group O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- YHBUQBJHSRGZNF-HNNXBMFYSA-N alpha-bisabolene Natural products CC(C)=CCC=C(C)[C@@H]1CCC(C)=CC1 YHBUQBJHSRGZNF-HNNXBMFYSA-N 0.000 description 1
- UZFLPKAIBPNNCA-UHFFFAOYSA-N alpha-ionone Natural products CC(=O)C=CC1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-UHFFFAOYSA-N 0.000 description 1
- UZFLPKAIBPNNCA-BQYQJAHWSA-N alpha-ionone Chemical compound CC(=O)\C=C\C1C(C)=CCCC1(C)C UZFLPKAIBPNNCA-BQYQJAHWSA-N 0.000 description 1
- VYBREYKSZAROCT-UHFFFAOYSA-N alpha-myrcene Natural products CC(=C)CCCC(=C)C=C VYBREYKSZAROCT-UHFFFAOYSA-N 0.000 description 1
- OGLDWXZKYODSOB-SNVBAGLBSA-N alpha-phellandrene Natural products CC(C)[C@H]1CC=C(C)C=C1 OGLDWXZKYODSOB-SNVBAGLBSA-N 0.000 description 1
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 235000019445 benzyl alcohol Nutrition 0.000 description 1
- 229930008407 benzylideneacetone Natural products 0.000 description 1
- DTCCTIQRPGSLPT-UHFFFAOYSA-N beta-Aethyl-acrolein Natural products CCC=CC=O DTCCTIQRPGSLPT-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- POIARNZEYGURDG-FNORWQNLSA-N beta-damascenone Chemical compound C\C=C\C(=O)C1=C(C)C=CCC1(C)C POIARNZEYGURDG-FNORWQNLSA-N 0.000 description 1
- 229930006722 beta-pinene Natural products 0.000 description 1
- 229930003493 bisabolene Natural products 0.000 description 1
- SIIVGPQREKVCOP-UHFFFAOYSA-N but-1-en-1-ol Chemical compound CCC=CO SIIVGPQREKVCOP-UHFFFAOYSA-N 0.000 description 1
- HUIYGGQINIVDNW-UHFFFAOYSA-N butyl anthranilate Chemical compound CCCCOC(=O)C1=CC=CC=C1N HUIYGGQINIVDNW-UHFFFAOYSA-N 0.000 description 1
- 229930006739 camphene Natural products 0.000 description 1
- ZYPYEBYNXWUCEA-UHFFFAOYSA-N camphenilone Natural products C1CC2C(=O)C(C)(C)C1C2 ZYPYEBYNXWUCEA-UHFFFAOYSA-N 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930006737 car-3-ene Natural products 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Natural products CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- IRAQOCYXUMOFCW-CXTNEJHOSA-N cedrene Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@H]1C(C)=CC2 IRAQOCYXUMOFCW-CXTNEJHOSA-N 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- CCRCUPLGCSFEDV-UHFFFAOYSA-N cinnamic acid methyl ester Natural products COC(=O)C=CC1=CC=CC=C1 CCRCUPLGCSFEDV-UHFFFAOYSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- VZWCCPAVZNSCEO-ARJAWSKDSA-N cis-3-Hexenyl 2-aminobenzoate Chemical compound CC\C=C/CCOC(=O)C1=CC=CC=C1N VZWCCPAVZNSCEO-ARJAWSKDSA-N 0.000 description 1
- NPFVOOAXDOBMCE-PLNGDYQASA-N cis-3-Hexenyl acetate Natural products CC\C=C/CCOC(C)=O NPFVOOAXDOBMCE-PLNGDYQASA-N 0.000 description 1
- RRGOKSYVAZDNKR-ARJAWSKDSA-M cis-3-hexenylacetate Chemical compound CC\C=C/CCCC([O-])=O RRGOKSYVAZDNKR-ARJAWSKDSA-M 0.000 description 1
- IVLCENBZDYVJPA-ARJAWSKDSA-N cis-Jasmone Natural products C\C=C/CC1=C(C)CCC1=O IVLCENBZDYVJPA-ARJAWSKDSA-N 0.000 description 1
- GQVMHMFBVWSSPF-UHFFFAOYSA-N cis-alloocimene Natural products CC=C(C)C=CC=C(C)C GQVMHMFBVWSSPF-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- BLBJUGKATXCWET-UHFFFAOYSA-N cyclaprop Chemical compound C12CC=CC2C2CC(OC(=O)CC)C1C2 BLBJUGKATXCWET-UHFFFAOYSA-N 0.000 description 1
- MMFCJPPRCYDLLZ-UHFFFAOYSA-N dec-2-enal Natural products CCCCCCCC=CC=O MMFCJPPRCYDLLZ-UHFFFAOYSA-N 0.000 description 1
- ZJIQIJIQBTVTDY-SREVYHEPSA-N dehydrolinalool Chemical compound CC(=C)\C=C/CC(C)(O)C=C ZJIQIJIQBTVTDY-SREVYHEPSA-N 0.000 description 1
- IRAQOCYXUMOFCW-UHFFFAOYSA-N di-epi-alpha-cedrene Natural products C1C23C(C)CCC3C(C)(C)C1C(C)=CC2 IRAQOCYXUMOFCW-UHFFFAOYSA-N 0.000 description 1
- DMSHWWDRAYHEBS-UHFFFAOYSA-N dihydrocoumarin Natural products C1CC(=O)OC2=C1C=C(OC)C(OC)=C2 DMSHWWDRAYHEBS-UHFFFAOYSA-N 0.000 description 1
- NKDDWNXOKDWJAK-UHFFFAOYSA-N dimethoxymethane Chemical compound COCOC NKDDWNXOKDWJAK-UHFFFAOYSA-N 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- MMCDSVCBSAMNPL-UHFFFAOYSA-N dodec-4-enal Chemical compound CCCCCCCC=CCCC=O MMCDSVCBSAMNPL-UHFFFAOYSA-N 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- OPCRGEVPIBLWAY-QNRZBPGKSA-N ethyl (2E,4Z)-deca-2,4-dienoate Chemical compound CCCCC\C=C/C=C/C(=O)OCC OPCRGEVPIBLWAY-QNRZBPGKSA-N 0.000 description 1
- BRGRZPQESQKATK-UHFFFAOYSA-N ethyl 2-acetyloctanoate Chemical compound CCCCCCC(C(C)=O)C(=O)OCC BRGRZPQESQKATK-UHFFFAOYSA-N 0.000 description 1
- YUIDGONLMDUWNF-UHFFFAOYSA-N ethyl 3-chloro-4h-thieno[3,2-b]pyrrole-5-carboxylate Chemical compound S1C=C(Cl)C2=C1C=C(C(=O)OCC)N2 YUIDGONLMDUWNF-UHFFFAOYSA-N 0.000 description 1
- LYRIITRHDCNUHV-UHFFFAOYSA-N ethyl 3-hydroxyhexanoate Chemical compound CCCC(O)CC(=O)OCC LYRIITRHDCNUHV-UHFFFAOYSA-N 0.000 description 1
- 229940093499 ethyl acetate Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- LTUMRKDLVGQMJU-UHFFFAOYSA-N famesylacetone Natural products CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=O LTUMRKDLVGQMJU-UHFFFAOYSA-N 0.000 description 1
- 229930009668 farnesene Natural products 0.000 description 1
- LTUMRKDLVGQMJU-IUBLYSDUSA-N farnesyl acetone Chemical compound CC(C)=CCC\C(C)=C\CC\C(C)=C\CCC(C)=O LTUMRKDLVGQMJU-IUBLYSDUSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000005755 formation reaction Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- IFYYFLINQYPWGJ-VIFPVBQESA-N gamma-Decalactone Natural products CCCCCC[C@H]1CCC(=O)O1 IFYYFLINQYPWGJ-VIFPVBQESA-N 0.000 description 1
- OALYTRUKMRCXNH-QMMMGPOBSA-N gamma-Nonalactone Natural products CCCCC[C@H]1CCC(=O)O1 OALYTRUKMRCXNH-QMMMGPOBSA-N 0.000 description 1
- PHXATPHONSXBIL-JTQLQIEISA-N gamma-Undecalactone Natural products CCCCCCC[C@H]1CCC(=O)O1 PHXATPHONSXBIL-JTQLQIEISA-N 0.000 description 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 description 1
- 229940020436 gamma-undecalactone Drugs 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- HNZUNIKWNYHEJJ-UHFFFAOYSA-N geranyl acetone Natural products CC(C)=CCCC(C)=CCCC(C)=O HNZUNIKWNYHEJJ-UHFFFAOYSA-N 0.000 description 1
- HNZUNIKWNYHEJJ-FMIVXFBMSA-N geranyl acetone Chemical compound CC(C)=CCC\C(C)=C\CCC(C)=O HNZUNIKWNYHEJJ-FMIVXFBMSA-N 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- NDFKTBCGKNOHPJ-UHFFFAOYSA-N hex-2-enal Natural products CCCCC=CC=O NDFKTBCGKNOHPJ-UHFFFAOYSA-N 0.000 description 1
- UBSCLHIMTAASFS-UHFFFAOYSA-N hexadeca-2,4-dienal Chemical compound CCCCCCCCCCCC=CC=CC=O UBSCLHIMTAASFS-UHFFFAOYSA-N 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-M hexanoate Chemical compound CCCCCC([O-])=O FUZZWVXGSFPDMH-UHFFFAOYSA-M 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- WPFVBOQKRVRMJB-UHFFFAOYSA-N hydroxycitronellal Chemical compound O=CCC(C)CCCC(C)(C)O WPFVBOQKRVRMJB-UHFFFAOYSA-N 0.000 description 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 description 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 description 1
- ONUFESLQCSAYKA-UHFFFAOYSA-N iprodione Chemical compound O=C1N(C(=O)NC(C)C)CC(=O)N1C1=CC(Cl)=CC(Cl)=C1 ONUFESLQCSAYKA-UHFFFAOYSA-N 0.000 description 1
- 229940117955 isoamyl acetate Drugs 0.000 description 1
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- QVDTXNVYSHVCGW-ONEGZZNKSA-N isopentenol Chemical compound CC(C)\C=C\O QVDTXNVYSHVCGW-ONEGZZNKSA-N 0.000 description 1
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
- 229940011051 isopropyl acetate Drugs 0.000 description 1
- 229940024423 isopropyl isobutyrate Drugs 0.000 description 1
- ZNJFBWYDHIGLCU-HWKXXFMVSA-N jasmonic acid Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-HWKXXFMVSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- UWKAYLJWKGQEPM-UHFFFAOYSA-N linalool acetate Natural products CC(C)=CCCC(C)(C=C)OC(C)=O UWKAYLJWKGQEPM-UHFFFAOYSA-N 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229930007503 menthone Natural products 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- CCRCUPLGCSFEDV-BQYQJAHWSA-N methyl trans-cinnamate Chemical compound COC(=O)\C=C\C1=CC=CC=C1 CCRCUPLGCSFEDV-BQYQJAHWSA-N 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229930008383 myrcenol Natural products 0.000 description 1
- DUNCVNHORHNONW-UHFFFAOYSA-N myrcenol Chemical compound CC(C)(O)CCCC(=C)C=C DUNCVNHORHNONW-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- 150000007823 ocimene derivatives Chemical class 0.000 description 1
- AVBRYQRTMPHARE-UHFFFAOYSA-N octyl formate Chemical compound CCCCCCCCOC=O AVBRYQRTMPHARE-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- VWMVAQHMFFZQGD-UHFFFAOYSA-N p-Hydroxybenzyl acetone Natural products CC(=O)CC1=CC=C(O)C=C1 VWMVAQHMFFZQGD-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- KRIOVPPHQSLHCZ-UHFFFAOYSA-N phenyl propionaldehyde Natural products CCC(=O)C1=CC=CC=C1 KRIOVPPHQSLHCZ-UHFFFAOYSA-N 0.000 description 1
- 229940100595 phenylacetaldehyde Drugs 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229960005235 piperonyl butoxide Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 229940116317 potato starch Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- GTVITUZSWANKRK-UHFFFAOYSA-N propan-2-yloxycyclododecane Chemical compound CC(C)OC1CCCCCCCCCCC1 GTVITUZSWANKRK-UHFFFAOYSA-N 0.000 description 1
- 239000000798 propyl (2E,4E)-deca-2,4-dienoate Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- GRWFGVWFFZKLTI-UHFFFAOYSA-N rac-alpha-Pinene Natural products CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 1
- NJGBTKGETPDVIK-UHFFFAOYSA-N raspberry ketone Chemical compound CC(=O)CCC1=CC=C(O)C=C1 NJGBTKGETPDVIK-UHFFFAOYSA-N 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000004170 rice bran wax Substances 0.000 description 1
- 235000019384 rice bran wax Nutrition 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 229930007790 rose oxide Natural products 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 229930006978 terpinene Natural products 0.000 description 1
- 150000003507 terpinene derivatives Chemical class 0.000 description 1
- MHRKPCRXBAHJGS-OAHLLOKOSA-N tert-butyl n-[[(3r)-1-benzylpyrrolidin-3-yl]methyl]carbamate Chemical compound C1[C@@H](CNC(=O)OC(C)(C)C)CCN1CC1=CC=CC=C1 MHRKPCRXBAHJGS-OAHLLOKOSA-N 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- MBDOYVRWFFCFHM-UHFFFAOYSA-N trans-2-hexenal Natural products CCCC=CC=O MBDOYVRWFFCFHM-UHFFFAOYSA-N 0.000 description 1
- NPFVOOAXDOBMCE-UHFFFAOYSA-N trans-3-hexenyl acetate Natural products CCC=CCCOC(C)=O NPFVOOAXDOBMCE-UHFFFAOYSA-N 0.000 description 1
- BWHOZHOGCMHOBV-BQYQJAHWSA-N trans-benzylideneacetone Chemical compound CC(=O)\C=C\C1=CC=CC=C1 BWHOZHOGCMHOBV-BQYQJAHWSA-N 0.000 description 1
- HRHOWZHRCRZVCU-UHFFFAOYSA-N trans-hex-2-enyl acetate Natural products CCCC=CCOC(C)=O HRHOWZHRCRZVCU-UHFFFAOYSA-N 0.000 description 1
- VTIODUHBZHNXFP-UHFFFAOYSA-N trans-hex-4-en-1-ol Natural products CC=CCCCO VTIODUHBZHNXFP-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- XMLSXPIVAXONDL-UHFFFAOYSA-N trans-jasmone Natural products CCC=CCC1=C(C)CCC1=O XMLSXPIVAXONDL-UHFFFAOYSA-N 0.000 description 1
- OVQVOKLGCDAZBX-UHFFFAOYSA-N triacontyl acetate Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCOC(C)=O OVQVOKLGCDAZBX-UHFFFAOYSA-N 0.000 description 1
- WKSPQBFDRTUGEF-UHFFFAOYSA-N tridec-2-enenitrile Chemical compound CCCCCCCCCCC=CC#N WKSPQBFDRTUGEF-UHFFFAOYSA-N 0.000 description 1
- 239000001069 triethyl citrate Substances 0.000 description 1
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
- 235000013769 triethyl citrate Nutrition 0.000 description 1
- XPQPWPZFBULGKT-UHFFFAOYSA-N undecanoic acid methyl ester Natural products CCCCCCCCCCC(=O)OC XPQPWPZFBULGKT-UHFFFAOYSA-N 0.000 description 1
- WCTNXGFHEZQHDR-UHFFFAOYSA-N valencene Natural products C1CC(C)(C)C2(C)CC(C(=C)C)CCC2=C1 WCTNXGFHEZQHDR-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000010698 whale oil Substances 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 229930007850 β-damascenone Natural products 0.000 description 1
- IHPKGUQCSIINRJ-UHFFFAOYSA-N β-ocimene Natural products CC(C)=CCC=C(C)C=C IHPKGUQCSIINRJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/72—Encapsulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
- Formation And Processing Of Food Products (AREA)
Abstract
本发明提供即便在高温多湿环境下也不会发生软化那样的情况,能够在热带等维持硬度且对胶囊施加力而能确认到碎裂的无缝胶囊。本发明涉及无缝胶囊及其制造方法,所述无缝胶囊的特征在于,其包含胶囊内容物和覆盖该胶囊内容物的覆膜层,前述覆膜层至少包含脱酰基型结冷胶和修饰淀粉,并且,前述胶囊内容物包含油性成分。
Description
技术领域
本发明涉及无缝胶囊及其制造方法,详细而言,涉及即便在高温多湿环境下也能够稳定崩解的无缝胶囊及其制造方法。
背景技术
无缝胶囊从粒径控制容易性、制造简略性等观点出发被用于多种用途。尤其是,封入有有用细菌的胶囊、封入有薄荷脑等香料的胶囊等已有销售。近年来其用途扩大,不仅像以往那样地寻求提高胶囊覆膜的强度而使其不易碎裂的技术,也寻求即便在热带那样的高温高湿环境下也稳定存在的技术。
WO2005/077419号公报(专利文献1)中提出了为了防止高温多湿下的附着而将酶分解卵磷脂配合至胶囊剂中。该技术是防止胶囊剂在高温多湿下发生附着的技术,也存在寻求即便在高温多湿环境下也能够维持胶囊覆膜材的硬度、对胶囊施加力而能够确认到碎裂的无缝胶囊的情况。尤其是,在作为热带季风气候的高温多湿且终年闷热的泰国曼谷等热带地域,有时寻求这种特性的无缝胶囊。
现有技术文献
专利文献
专利文献1:WO2005/077419A
发明内容
发明所要解决的课题
本发明提供即便在高温多湿环境下也不会发生软化那样的情况,能够在热带等维持硬度且对胶囊施加力而能够确认到破碎的无缝胶囊。
用于解决课题的手段
本发明人等为了解决上述目的而反复进行深入研究,结果发现:通过在胶囊的覆膜材料中使用特定材料,从而达成上述目的。
本发明提供以下的方式。
[1]无缝胶囊,其包含胶囊内容物和覆盖该胶囊内容物的覆膜层,所述胶囊的特征在于,
前述覆膜层至少包含脱酰基型结冷胶和修饰淀粉,
前述胶囊内容物包含油性成分。
[2]根据[1]所述的无缝胶囊,其中,前述覆膜层以按照覆膜重量基准计为70重量%以上且98.5重量%以下的量包含脱酰基型结冷胶,以按照覆膜重量基准计为0.01重量%以上且30重量%以下的量包含修饰淀粉。
[3]根据[1]或[2]所述的无缝胶囊,其特征在于,前述覆膜层还包含结晶纤维素。
[4]根据[1]~[3]中任一项所述的无缝胶囊,其特征在于,前述无缝胶囊的粒径为0.5~8.0mm,并且,覆膜率为5%以上且40%以下。
[5]根据[1]~[4]中任一项所述的无缝胶囊,其中,前述修饰淀粉为氧化淀粉。
[6]根据[1]~[5]中任一项所述的无缝胶囊,其中,前述胶囊内容物中的油状成分包含香料。
[7]根据[1]~[6]中任一项所述的无缝胶囊,其中,前述香料为选自留兰香、薄荷脑、薄荷、柑橘、柚子、玫瑰、柠檬、葡萄柚、金橘、桃子、苹果、香蕉、菠萝、葡萄、芒果、热带水果、蓝莓、蔓越橘、红豆越橘、美洲越橘、木莓、黑莓、洛根莓、美莓、博伊森树莓、草莓、欧洲越橘、接骨木果和醋栗中的至少一种。
[8]根据[1]~[7]中任一项所述的无缝胶囊,其中,前述无缝胶囊具有胶囊内容物与覆膜层的两层结构、或者在胶囊内容物与覆膜层之间具有中间层的三层结构。
[9]根据[1]~[8]中任一项所述的无缝胶囊,其特征在于,将前述无缝胶囊在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的载荷记作X(N),将破坏时位移记作Y(mm),同样地将前述无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的载重记作x(N),将破坏时位移记作y(mm)时,XY/xy的值处于0.76以上且1.15以下的范围内。
[10]根据[1]~[8]中任一项所述的无缝胶囊,其特征在于,将前述无缝胶囊在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的载荷记作X(N),将破坏时位移设为Y(mm),同样地将前述无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的载重记作x(N),将破坏时位移记作y(mm)时,XY/xy的值处于0.76以上且1.32以下的范围内。
[11][1]所述的无缝胶囊的制造方法,其为利用滴加法来制造无缝胶囊的方法,所述滴加法中,将从内侧喷嘴和外侧喷嘴以同心圆状存在的双重喷嘴同时喷出的喷出液滴加至冷却液中,
所述制造方法的特征在于,
从内侧喷嘴喷出胶囊内容物液,
从外侧喷嘴喷出覆膜层液,
前述胶囊内容物液包含油性成分,且将胶囊内容物液的温度在5℃~30℃的范围内控制至设定值±2℃,
前述覆膜层液至少包含脱酰基型结冷胶和修饰淀粉,且将覆膜层液的温度在60℃~90℃的范围内控制为设定值±2℃,
前述冷却液包含油,且将冷却液的温度在10℃~30℃的范围内控制为设定值±2℃,
将前述覆膜层液的温度与前述冷却液的温度之差控制为30℃以上且80℃以下的范围。
[12][1]所述的无缝胶囊的制造方法,其为利用滴加法来制造无缝胶囊的方法,所述滴加法中,将从内侧喷嘴、中间喷嘴和外侧喷嘴以同心圆状存在的三重喷嘴同时喷出的喷出液滴加至冷却液中,
所述制造方法的特征在于,
从内侧喷嘴喷出胶囊内容物液,
从中间喷嘴喷出中间层液,
从外侧喷嘴喷出覆膜层液,
前述胶囊内容物液包含油性成分,且将胶囊内容物液的温度在5℃~30℃的范围内控制至设定值±2℃,
将前述中间层液的温度在40~85℃的范围内控制为设定值±2℃,
前述覆膜层液至少包含脱酰基型结冷胶和修饰淀粉,且将覆膜层液的温度在60℃~90℃的范围内控制为设定值±2℃,
前述冷却液包含油,且将冷却液的温度在10℃~30℃的范围内控制为设定值±2℃,
将前述覆膜层液的温度与前述冷却液的温度之差控制为30℃以上且80℃以下的范围。
[13]根据[11]或[12]所述的无缝胶囊的制造方法,其中,前述修饰淀粉为氧化淀粉。
[14]根据[11]~[13]中任一项所述的无缝胶囊的制造方法,其特征在于,前述覆膜层还包含结晶纤维素。
[15]根据[11]~[14]中任一项所述的无缝胶囊的制造方法,其中,前述胶囊内容物液中的油状成分包含香料。
[16]根据[11]~[15]中任一项所述的无缝胶囊的制造方法,其中,前述香料为选自留兰香、薄荷脑、薄荷、柑橘、柚子、玫瑰、柠檬、葡萄柚、金橘、桃子、苹果、香蕉、菠萝、葡萄、芒果、热带水果、蓝莓、蔓越橘、红豆越橘、美洲越橘、木莓、黑莓、洛根莓、美莓、博伊森树莓、草莓、欧洲越橘、接骨木果和醋栗中的至少一种。
发明效果
本发明中,通过使无缝胶囊的胶囊覆膜层使用脱酰基型结冷胶和修饰淀粉,从而即便无缝胶囊的覆膜率低,也不会在高温多湿环境下发生软化,能够维持硬度,在碎裂时维持发声。
附图说明
图1表示能够崩解的胶囊的一个实施方式的三层结构的无缝胶囊的示意图。
图2是适于使用三层喷嘴并通过滴加法来制造三层结构的无缝胶囊的制造装置的喷嘴部的剖视示意图。
具体实施方式
本发明提供无缝胶囊,其包含胶囊内容物和覆盖该胶囊内容物的覆膜层,所述无缝胶囊的特征在于,前述覆膜层包含脱酰基型结冷胶和修饰淀粉,前述胶囊内容物包含油性成分。无缝胶囊可以具有胶囊内容物与覆膜层的两层结构,另外,也可以具有在胶囊内容物与覆膜层之间具有中间层的三层结构。在三层结构的无缝胶囊的情况下,中间层有时也与胶囊内容物部分或全部混浊或混相而无法明确识别出中间层。以下,参照附图来说明三层结构的无缝胶囊。
图1表示能够崩解的胶囊的一个实施方式的示意图。如图1所示那样,无缝胶囊4是具有胶囊内容物1和覆膜层2,并根据需要还具有中间层3的无缝胶囊。胶囊内容物1被覆膜层2封入。胶囊的内容物1包含香料等油性成分,覆膜层2包含脱酰基型结冷胶和修饰淀粉。无缝胶囊4能够崩解,通过用指施加压力,从而覆膜层2发生破裂,胶囊内容物1被释放至胶囊外部。具体而言,通过使覆膜层2发生破损,从而释放出胶囊内容物1的油性成分即香料等,能够享受香气。在本说明书中,“能够崩解”是指:胶囊覆膜能够因外压而崩解,并释放出内容物。
<胶囊内容物>
关于胶囊内容物,以水作为主成分且包含油性成分的方式、包含油性成分作为主成分的方式、以及仅由油性成分构成的方式均可采用。具体而言,“包含油性成分作为主成分”是指:相对于胶囊内容物的总重量,油性成分例如占50重量%以上、优选占60重量%以上、更优选占70重量%以上、进一步优选占80重量%以上。具体而言,“以水作为主成分且包含油性成分”是指:相对于胶囊内容物的总重量,水成分例如占80重量%以下、优选占70重量%以下、更优选占60重量%以下。
作为油性成分,没有特别限定,可列举出例如香料、谷物油、果实油、亲油性溶剂等。油性成分优选包含香料,更优选包含香料和亲油性溶剂。另外,前述油性成分可使用公知材料,以油/水/油型乳液的形式进行制备。油性成分可以单独使用1种,也可以混合使用2种以上。
作为香料,只要是油性成分就没有特别限定,可以使用天然香料、合成香料中的任一者。香料可以单独使用1种,也可以混合使用2种以上。作为天然香料,没有特别限定,可列举出例如玫瑰、茉莉、苦橙·橙花油、白花母菊、依兰、老鹳草、桉树、澳洲茶树、苦橙叶、温州蜜橘、柑橘、柠檬、酸橙、香柠檬、胡椒、刺柏、香草、白檀、松树、日本扁柏、肉桂、乳香、没药、香根草、甘松、鸢尾草的根、薰衣草、柠檬草、罗勒、迷迭香、薄荷类(例如留兰香、薄荷脑、薄荷等)和莓类(例如蓝莓、蔓越橘、红豆越橘、美洲越橘、木莓、黑莓、洛根莓、美莓、博伊森树莓、草莓、欧洲越橘、接骨木果和醋栗等)等的油。作为合成香料,只要是一直以来出于赋予香气/香味的目的而使用的香料,就没有特别限定。可列举出例如酯类、醇类、醛类、酮类、酚类、醚类、内酯类、烃类、含氮化合物、含硫化合物类、酸类或它们的混合物等。
作为用作油性成分的香料的酯类,没有特别限定,可列举出例如甲酸丙酯、甲酸丁酯、甲酸戊酯、甲酸辛酯、甲酸里哪酯、甲酸香茅醇酯、甲酸香叶酯、甲酸橙花醇酯、甲酸松油酯、乙酸乙酯、乙酸异丙酯、乙酸异戊酯、乙酸己酯、乙酸顺式-3-己烯酯、乙酸反式-2-己烯酯、乙酸辛酯、乙酸壬酯、乙酸癸酯、乙酸十二烷基酯、乙酸二甲基十一碳二烯酯、乙酸苯仲乙酯、乙酸罗勒醇酯、乙酸月桂烯酯、乙酸二氢月桂烯酯、乙酸里哪酯、乙酸香茅醇酯、乙酸香叶酯、乙酸橙花醇酯、乙酸四氢铃兰醇酯、乙酸薰衣草酯、乙酸橙花叔醇酯、乙酸二氢枯茗酯、乙酸松油酯、乙酸柠檬油酯、乙酸诺卜醇酯、乙酸二氢松油酯、乙酸2,4-二甲基-3-环己烯基甲酯、乙酸柑青酯、乙酸波提酯、丙酸癸烯酯、丙酸里哪酯、丙酸香叶酯、丙酸橙花醇酯、丙酸松油酯、丙酸三环癸烯酯、丙酸苯仲乙酯、丙酸茴香偶酰基酯、丁酸辛酯、丁酸橙花醇酯、丁酸肉桂酯、异丁酸异丙酯、异丁酸辛酯、异丁酸里哪酯、异丁酸橙花醇酯、异戊酸里哪酯、异戊酸松油酯、异戊酸苯基乙酯、2-甲基戊酸2-甲基戊酯、3-羟基己烷酸甲酯、3-羟基己酸乙酯、辛酸甲酯、辛酸辛酯、辛酸里哪酯、壬烷酸甲酯、十一碳烯酸甲酯、苯甲酸里哪酯、肉桂酸甲酯、当归酸-3-甲基-3-丁烯-1-醇酯、牻牛儿酸甲酯、柠檬酸三乙酯、乙酰乙酸乙酯、2-己基乙酰乙酸乙酯、苄基乙酰乙酸乙酯、2-乙基丁酸烯丙酯、3-羟基丁酸乙酯、壬烷酸乙酯、癸酸乙酯、2,4-癸二烯酸乙酯、2,4-癸二烯酸丙酯、氨茴酸甲酯和里哪酯、N-甲基氨茴酸乙酯等。
作为用作油性成分的香料的醇类,没有特别限定,可列举出例如3-庚醇、1-壬醇、正十一烷醇、2-十一烷醇、正十二烷醇、异戊烯醇、10-十一碳烯-1-醇、二氢里哪醇、四氢铃兰醇、月桂烯醇、二氢月桂烯醇、四氢月桂烯醇、罗勒烯醇、萜品醇、脱氢芳樟醇、3-侧柏醇、苄醇、β-苯基乙醇、α-苯基乙醇、3-甲基-1-戊醇、1-庚醇、2-庚醇、3-辛醇、1-壬醇、2-壬醇、2,6-二甲基庚醇、1-癸醇、反式-2-己烯醇、顺式-4-己烯醇、甲基三甲基环戊烯基丁烯醇、香茅醛、二氢月桂烯醇、玫红醇、香叶醇、橙花醇、里哪醇、四氢里哪醇、二甲基辛醇、羟基香茅醛、异蒲勒醇、薄荷脑(例如l-薄荷脑)、萜品醇、二氢萜品醇、葛缕醇、二氢葛缕醇、紫苏醇、4-侧柏醇、桃金娘烯醇、α-小茴香醇、法呢醇、橙花叔醇、雪松烯醇、茴香醇、氢化阿托醇、3-苯基丙基醇、肉桂醇、戊基肉桂醇等。
作为用作油性成分的香料的醛类,没有特别限定,可列举出例如乙醛、正己醛、正庚醛、正辛醛、正壬醛、2-甲基辛醛、3,5,5-三甲基己醛、癸醛、十一醛、2-甲基癸醛、十二醛、十三醛、十四醛、反式-2-己烯醛、反式-4-癸烯醛、顺式-4-癸烯醛、反式-2-癸烯醛、10-十一碳烯醛、反式-2-十一碳烯醛、反式-2-十二碳烯醛、3-十二碳烯醛、反式-2-十三碳烯醛、2,4-十六碳二烯醛、2,4-癸二烯醛、2,4-十二碳二烯醛、5,9-二甲基-4,8-癸二烯醛、柠檬醛、二甲基辛醛、α-亚甲基香茅醛、香茅醇氧基乙醛、桃金娘烯醛、橙花醛、α-或β-甜橙醛、柑青醛、苯基乙醛、辛醛二甲基缩醛、壬醛二甲基缩醛、癸醛二甲基缩醛、癸醛二乙基缩醛、2-甲基十一碳醛二甲基缩醛、柠檬醛二甲基缩醛、柠檬醛二乙基缩醛、柠檬醛丙二醇缩醛、正戊醛、异戊醛、2-甲基丁醛、2-戊烯醛、反式-2-庚烯醛、反式-2-壬烯醛、2,6-二甲基-5-庚烯醛、2,4-十一碳二烯醛、三甲基癸二烯醛、香茅醛、羟基香茅醛、藏红花醛、1-甲基-4-(4-甲基戊基)环己-3烯-1-甲醛、苯甲醛、对异丙基苯基乙醛、对甲基氢化阿托醛、苯丙醛、2-甲基-3-(4-甲基苯基)丙醛、仙客来醛、肉桂醛、水杨醛、茴香醛、对甲基苯氧基乙醛、乙醛二乙基缩醛、香茅醇甲基缩醛、乙醛2-苯基-2,4-戊二醇缩醛、2-己烯醛二乙基缩醛、顺式-3-己烯醛二乙基缩醛、庚醛二乙基缩醛、2-己基-5-甲基-1,3-二氧戊环、香茅醛环单二醇缩醛、羟基香茅醛二甲基缩醛、苯基乙醛二甲基缩醛等。
作为用作油性成分的香料的酮类,没有特别限定,可列举出例如2-戊酮、3-己酮、2-庚酮、3-庚酮、4-庚酮、2-辛酮、3-辛酮、2-壬酮、2-十一烷酮、甲基戊烯酮、二甲基辛烯酮、香叶基丙酮、法呢基丙酮、2,3,5-三甲基-4-环己烯基-1-甲基酮、橙花酮、诺卡酮、二氢诺卡酮、苯乙酮、4,7-二氢-2-异戊基-2-甲基-1,3-正丙基七环、2-戊酮、3-己酮、2-庚酮、2,3-己二酮、3-壬酮、乙基异戊酮、丁二酮、戊基环戊烯酮、2-环戊基环戊酮、己基环戊酮、庚基环戊酮、顺式-茉莉酮、二氢茉莉酮、三甲基戊基环戊酮、2-(2-(4-甲基)-3-环己烯-1-基)丙基环戊酮、大马酮、α-王朝酮、三甲基环己烯基丁烯酮、α-紫罗酮、β-紫罗酮、甲基紫罗酮、烯丙基紫罗酮、7-甲基-八氢-1,4-甲醇萘-6(2H)-酮、开司米酮、l-香芹酮、薄荷酮、樟脑、对甲基苯乙酮、对甲氧基苯乙酮、苯甲叉基丙酮、木莓酮、甲基萘基酮、二苯甲酮、糠醛丙酮、酱油酮、麦芽醇、乙基麦芽醇、乙酰乙酸乙酯乙二醇缩酮等。
作为用作油性成分的香料的酚类,没有特别限定,可列举出例如百里酚、香芹酚、β-萘酚异丁基醚、茴香脑、β-萘酚甲基醚、β-萘酚乙基醚、甲氧甲酚、藜芦醚、氢醌二甲基醚、2,6-二甲氧基苯酚、4-乙基愈创木酚、丁子香酚、异丁子香酚、乙基异丁子香酚、叔丁基氢醌二甲基醚等。
作为用作油性成分的香料的醚类,没有特别限定,可列举出例如癸基乙烯基醚、α-松油基甲基醚、异普双环烷、2,2-二甲基-5-(1-甲基-1-丙烯基)四氢呋喃、玫瑰呋喃、1,4-桉树脑、橙花醇氧化物、2,2,6-三甲基-6-乙烯基四氢吡喃、甲基己基醚、罗勒烯环氧化物、柠檬烯氧化物、胡椒醚(RHUBOFIX)、丁子香烯氧化物、里哪醇氧化物、5-异丙烯基-2-甲基-2-乙烯基四氢呋喃、橙花醇氧化物、玫瑰氧化物等。
作为用作油性成分的香料的内酯类,没有特别限定,可列举出例如γ-十一内酯、δ-十二内酯、γ-己内酯、γ-壬内酯、γ-癸内酯、γ-十二内酯、茉莉内酯、甲基-γ-癸内酯、7-癸烯内酯、茉莉酸内酯内酯、丙叉基苯酞、δ-己内酯、δ-2-癸烯内酯、ε-十二内酯、二氢香豆素、香豆素等。
作为用作油性成分的香料的烃类,没有特别限定,可列举出例如罗勒烯、柠檬烯、α-水芹烯、萜品烯、3-蒈烯、红没药烯、朱栾倍半萜、别罗勒烯、香叶烯、法呢烯、α-蒎烯、β-蒎烯、莰烯、萜品油烯、对伞花烃、雪松烯、β-丁子香烯、杜松萜烯等。
作为用作油性成分的香料的含氮化合物或含硫化合物类,没有特别限定,可列举出例如氨茴酸甲酯、氨茴酸乙酯、正甲基氨茴酸甲酯、正-2’-甲基戊亚基氨茴酸甲酯、女贞缩醛、十二烷腈、2-十三碳烯腈、香叶腈、香茅腈、3,7-二甲基-2,6-壬二烯腈、吲哚、5-甲基-3-庚酮肟、柠檬烯硫醇、1-对薄荷烯-8-硫醇、氨茴酸丁酯、氨茴酸顺式-3-己烯酯、氨茴酸苯基乙酯、氨茴酸肉桂酯、二甲硫醚、8-巯基薄荷酮等。
本发明的胶囊内容物可以进一步适当配合有赋形剂、稳定剂、表面活性剂、辅助剂或发泡剂等。这些配合剂的量没有特别限定,不能是阻碍本发明的无缝胶囊的作用的量。
<中间层>
本发明的无缝胶囊中,在胶囊内容物的外侧形成中间层。中间层至少为1层,可以为多层。在多层的情况下,可以以相同的配合来使用,也可以以不同的配合来使用,通常,中间层为1层。以下,为了简便而将中间层设为1层来进行说明。在中间层中,作为可用于制备胶囊内容物的油性组合物,可列举出例如橄榄油、荷荷巴油、玉米油、菜籽油、猪油、牛油、鲸油、蜂蜡、蓖麻油、大豆油、米油、米胚芽油、椰油、棕榈油、可可油、鳄梨油、澳洲坚果油、角鲨烷、貂油、海龟油、玉米油、中链脂肪酸甘油三酯(MCT)、长链脂肪酸甘油三酯(LCT)、碳原子数为8~30的烃类、蜜蜡、巴西棕榈蜡、米糠蜡、羊毛脂、液体石蜡、凡士林、碳原子数为4~30的脂肪酸、碳原子数为4~30的脂肪酸与蔗糖的酯、碳原子数为4~30的脂肪酸与甘油的酯、碳原子数为4~30的脂肪族醇、碳原子数为4~30的脂肪酸与碳原子数为4~30的脂肪族醇的酯、以及硅油等。可以仅使用它们中的1种,或者,也可以混合使用2种以上。这些油性组合物之中,更优选在-30℃~60℃的温度范围内的粘度为200mPa·s以下的液体油脂。
在中间层中,为了调整界面张力和粘性、比重,可以单独或组合配合卵磷脂或异丁酸乙酸蔗糖酯(SAIB)、二氧化硅。这些配合剂的量没有特别限定,不能是损害本发明的无缝胶囊的作用的量。
<覆膜层>
进一步利用覆膜层来覆盖中间层。覆膜层含有脱酰基型结冷胶和修饰淀粉。结冷胶(也被称为“结冷胶”)是由作为革兰氏阴性菌的伊乐假单胞菌(Pseudomonas elodea)产出的水溶性多糖类,且是直链状的杂多糖类,由葡萄糖、葡糖醛酸、葡萄糖、鼠李糖这四个糖的重复单元构成。结冷胶根据进行了1-3键合的葡萄糖中存在的乙酰基和甘油基的有无而存在脱酰基型结冷胶和天然型结冷胶这两种,本发明中可以使用脱酰基型结冷胶。脱酰基型结冷胶可以使用市售品,可列举出ケルコゲル(KELCOGEL:商标)F、ゲルザン(GELZAN:商标)CM(均为シーピーケルコ(CPKelco)公司制)。
脱酰基型结冷胶以按照覆膜重量基准计为70重量%以上且98.5重量%以下的量而含有于覆膜层。优选为70重量%以上且97重量%以下。若脱酰基型结冷胶少于70重量%,则胶囊覆膜的硬度不足而发生碎裂时不会发出声音。若超过98重量%,则存在变得过硬的倾向。
覆膜层也包含修饰淀粉(也被称为“加工淀粉”)。淀粉存在未修饰淀粉和修饰淀粉,未修饰淀粉可列举出例如玉米淀粉、糯玉米淀粉、木薯淀粉、马铃薯淀粉、米淀粉、小麦淀粉、西米淀粉中的任一者或它们的组合。修饰淀粉是对这些未修饰淀粉进行修饰(或加工)而得到的,其进行了氧化、酸处理、α化、乙酰化、醚化、磷酸交联、己二酸交联中的任一中处理或它们的组合处理。
未修饰淀粉的酸处理具有低粘度化、提高透明性/粘度稳定性等效果。α化具有冷水可溶效果。乙酰化具有降低糊化温度、提高透明性或保水性、耐老化性等效果。未修饰淀粉的氧化具有提高由淀粉的低粘度化带来的烹调时的作业效率、提高透明性等效果。另外,通过未修饰淀粉的氧化而将淀粉溶解于水等时,能够提高薄片的固体成分含量而不使其糊液高粘度化,因此,也具有提高粘度稳定性的效果。淀粉的醚化具有由糊化温度降低实现的软胶囊的粘接温度降低、提高透明性/保水性、耐老化性、耐盐性、耐剪切性等效果,另外,具有能够容易地制成薄片的优点。醚化存在例如羟丙基化等。淀粉的磷酸交联具有防止由酸、碱、机械剪切导致的粘度降低和凝胶崩解、使淀粉薄膜耐水化的效果。乙酰化具有由糊化温度降低实现的软胶囊的粘接温度降低、提高透明性等效果。本发明中使用的修饰淀粉优选为氧化淀粉。
本发明中,覆膜层以按照覆膜重量基准计为0.01重量%以上且小于30重量%的量包含修饰淀粉。修饰淀粉优选以0.02重量%以上且25重量%以下包含在覆膜层中。若修饰淀粉少于0.01重量%,则硬度不足,若超过30重量%,则存在变脆的倾向。
本发明的无缝胶囊的覆膜层可以以干燥状态根据需要含有增塑剂,作为上述增塑剂的例子,可列举出甘油、山梨糖醇等。上述增塑剂的配合量以干燥后的覆膜总重量为基准计为1~50质量%、优选为5~40质量%、更优选为15~30质量%。上述增塑剂的配合量小于1质量%时,覆膜不耐真空干燥,或者,在干燥状态下无法保持充分的柔软性而产生裂纹,若超过50质量%,则覆膜软化,在高温下发生附着、溶解。
本发明的无缝胶囊的覆膜层根据需要可以在上述组成的基础上,还包含结晶纤维素、纤维素衍生物、香料、甜味剂、着色剂、对羟基苯甲酸酯等防腐剂等在该领域中通常使用的各种添加剂。使用这种添加剂时的全部添加剂的总含量相对于胶囊覆膜层组合物中的总固体成分重量例如为0.01重量%~10重量%,优选为0.1重量%~5重量%。
结晶纤维素也被称为微晶纤维素,其是将由纤维性植物得到的α-纤维素用酸部分解聚并精制而得到的。其是葡萄糖单元借助β(1→4)糖苷键连接而得到的,不溶于水、稀酸和大多数的有机溶剂但具有吸湿性的化合物。由各公司销售有アビセルPH系列、セレックス101、セオルス、エムコセル、ビバセル系列等。纤维素衍生物是上述纤维素的羟基被烷基醚(-O-M)基和/或脂肪酸酯基(-C(=O)-M)(M:烷基)取代而得到的化合物,具有溶解于水等的性质。
本发明的无缝胶囊的直径(D)(mm)没有特别限定,可根据无缝胶囊的使用情况来设定。在实施方式中,胶囊的直径(D)为0.5~8.0mm、优选为1.0~7.0mm。
本发明的无缝胶囊在干燥后的覆膜层的覆膜率(%)通过{(覆膜的厚度)×2/D×100来提供,优选为5%以上且40%以下,优选的是,具有10%~35%是理想的。上述覆膜率小于5%时,覆膜强度低,若超过40%,则内容物量变少,崩解性也变差。
通过调整无缝胶囊的覆膜的组成和量、调整胶囊内容液的组成和量、调整胶囊制造工序(例如后述液中滴加法中的冷却工序、干燥工序等)等,从而能够将胶囊的直径和破坏强度调整至本发明的范围。
例如,在直径约为3.5mm的无缝胶囊的情况下,本发明的无缝胶囊的总重量优选为17~30mg,更优选为18~27mg,进一步优选为19~25mg。
在优选实施方式中,通过对本发明的无缝胶囊施加外压,从而胶囊覆膜发生破裂。在优选实施方式中,胶囊在破裂时崩开,发出破裂音。胶囊的形状没有特别限定,例如可以为球状,也可以为足球状。优选为球状,更优选为正球状。在制成正球状的情况下,更详细而言,胶囊的短径/长径之比没有特别限定,优选为0.90~1.00,更优选为0.95~1.00。
<无缝胶囊的碎裂性能>
如上所述那样,本发明的无缝胶囊具有特定的碎裂性能,具体而言,通过施加外压而使胶囊覆膜发生破裂,优选具有在无缝胶囊破裂时崩开、发出破裂音的性能。因此,本发明的无缝胶囊具有以下那样的碎裂特性。
将本发明的无缝胶囊在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的载荷记作X(N),同样地将本发明的无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的载重记作x(N)时,X/x的值没有特别限定,优选处于0.6以上且1.3以下的范围内,更优选处于0.7以上且1.2以下的范围内。
将本发明的无缝胶囊在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的破坏时位移记作Y(mm),同样地将本发明的无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的破坏时位移记作y(mm)时,Y/y的值优选处于0.9以上且2.1以下的范围内,更优选处于1.0以上且2.0以下的范围内。
具体而言,对于本发明的无缝胶囊而言,在内容物以油性成分作为主成分的胶囊的情况下,在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的载荷记作X(N),将破坏时位移记作Y(mm),同样地将无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的载重记作x(N),将破坏时位移记作y(mm)时,XY/xy(通过X与Y的乘积除以x与y的乘积而得到的值)的值优选处于0.76以上且1.15以下的范围内。若满足这种数值范围,则无缝胶囊因外压而碎裂,根据情况,发出崩开那样的破裂音。若上述XY/xy的值小于0.76,若值小于0.76,则在高温多湿状况下无法保持胶囊的强度,具有容易碎裂的缺点,若超过1.15,则在相同状况下,存在胶囊变得过于柔软、不易碎裂的缺点。另外,上述x、X、y和Y后的括弧内的记载是对单位加以记载,N为牛顿,mm为毫米。另外,关于“最小粒径方向”,无缝胶囊在制法上是接近大致正球的形状,但考虑到呈现足球状的情况,由于短径的方向最稳定,因此,将其设为最小粒径方向。
同样地,在内容物以水性成分作为主成分的胶囊的情况下,若上述XY/xy的值小于0.76,则具有在高温多湿状况下无法保持胶囊强度、容易碎裂的缺点,若超过1.32,则在相同的状况下具有胶囊过于柔软、不易碎裂的缺点。
本说明书中,破坏时的载荷和破坏时位移通过对无缝胶囊颗粒沿着垂直方向连续施加载荷直至崩解为止来测定。胶囊破坏瞬间的最大载荷为胶囊的破坏强度(N)。破坏强度(N)可以使用例如流变仪(由サン科学公司等上市销售)来测定。
本说明书中,胶囊的粒径可通过利用数字游标卡尺进行测定并采取平均值来评价。另外,本说明书中,胶囊的覆膜厚度可通过将胶囊对半切割,利用数字显微镜进行测定并采取平均值来评价。
<无缝胶囊的制造方法>
本发明的无缝胶囊利用所谓被称为滴加法的制造方法来制造。滴加法是从喷嘴向流体中滴加液滴,并利用借助表面张力而呈现球状的现象来制造的方法。本发明的无缝胶囊如上所述那样,可以具有胶囊内容物与覆膜层的两层结构,另外,也可以具有在胶囊内容物与覆膜层之间具有中间层的三层结构,因此,记载具有两层结构时的制造方法和具有三层结构时的制造方法。
(两层结构的无缝胶囊的制造方法)
无缝胶囊的制造方法,其基于滴加法,所述滴加法中,将从内侧喷嘴和外侧喷嘴以同心圆状存在的双重喷嘴同时喷出的喷出液滴加至冷却液中,
所述无缝胶囊的制造方法中,通过如下操作来进行制造:
从内侧喷嘴喷出胶囊内容物液,
从外侧喷嘴喷出覆膜层液,
前述胶囊内容物液包含油性成分,且将胶囊内容物液的温度在5℃~30℃(优选在10~30℃)的范围内控制至设定值±2℃(优选为±1℃),
前述覆膜层液至少包含脱酰基型结冷胶和修饰淀粉,且将覆膜层液的温度在60℃~90℃的范围内控制至设定值±2℃(优选为±1℃),
前述冷却液包含油,且将冷却液的温度在10℃~30℃(优选在12~30℃)的范围内控制至设定值±2℃(优选为±1℃),
将前述覆膜层液的温度与前述冷却液的温度之差控制至30℃以上且80℃以下(优选为35℃以上且73℃以下)的范围。
(三层结构的无缝胶囊的制造方法)
无缝胶囊的制造方法,其基于滴加法,所述滴加法中,将从内侧喷嘴、中间喷嘴和外侧喷嘴以同心圆状存在的三重喷嘴同时喷出的喷出液滴加至冷却液中,
所述无缝胶囊的制造方法中,通过如下操作来进行制造:
从内侧喷嘴喷出胶囊内容物液,
从中间喷嘴喷出中间层液,
从外侧喷嘴喷出覆膜层液,
前述胶囊内容物液包含油性成分,且将胶囊内容物液的温度在5℃~30℃(优选在10~30℃)的范围内控制至设定值±2℃(优选为±1℃),
将前述中间层液的温度在40℃~85℃(优选在45~85℃)的范围内控制至设定值±2℃(优选为±1℃),
前述覆膜层液至少包含脱酰基型结冷胶和修饰淀粉,且将覆膜层液的温度在60℃~90℃(优选在65~85℃)的范围内控制至设定值±2℃(优选为±1℃),
前述冷却液包含油,且将冷却液的温度在10℃~30℃(优选在12~30℃)的范围内控制为设定值±2℃,
将前述覆膜层液的温度与前述冷却液的温度之差控制至30℃以上且80℃以下(优选为35℃以上且73℃以下)的范围。
关于上述温度条件,如果是本领域技术人员,则可根据无缝胶囊所需的品质程度来适当选择。
在制造本发明的无缝胶囊时,满足上述的全部条件是特别重要的,如果是本领域技术人员,则可通过例如将PID控制与前馈控制加以组合来容易地进行上述温度控制,但不限定于这些控制方法。
图2中示出适合于使用三层喷嘴并通过滴加法来制造三层结构无缝胶囊的制造装置的喷嘴部的剖视示意图。
图2表示从喷嘴截面A喷出的无缝胶囊喷流B在冷却液18中断裂并逐渐形成各个无缝胶囊17的状态。喷嘴截面A处,内侧喷嘴11、中间喷嘴12和外侧喷嘴13以同心圆状存在,从内侧喷嘴11中喷出胶囊内容物液14,从中间喷嘴12(具体为中间喷嘴12与内侧喷嘴11之间)喷出中间层液15,从外侧喷嘴13(具体为外侧喷嘴13与中间喷嘴12之间)喷出覆膜层液16,三种溶液同时喷出而形成无缝胶囊喷流B。
如上操作而得到的无缝胶囊在5℃~30℃下进行2~12小时的通风干燥。另外,在需要进一步降低无缝胶囊的水分含量的情况下,可以在通风干燥后进一步进行真空干燥或真空冻结干燥。其是如下方法:在真空干燥中,将真空度保持至0.002~0.5MPa以下,进而,在真空冻结干燥中,在-20℃以下使其冻结并干燥。真空干燥或真空冻结干燥所需的时间没有特别限定,通常为5~60小时、优选为24~48小时。若为5小时以下,则干燥不充分,胶囊内存在的水对内容物造成不良影响。
实施例
接着,列举出实施例,更具体地说明本发明,但本发明不受这些实施例的限定性解释。在实施例中,份、%等只要没有特别指示,就基于重量或质量。
实施例1
将下述表1的覆膜层一栏记载的重量份的脱酰化结冷胶、氯化钙、氧化淀粉和蓝色一号与水32333重量份混合,在95℃下溶解并静置脱泡,制作胶囊覆膜液。
使用将前述胶囊覆膜液、作为中间层的蔗糖乙酸酯异丁酸酯857重量份与中链脂肪酸甘油三酯143重量份的混合物、作为胶囊内容物的l-薄荷脑200重量份、中链脂肪酸甘油三酯800重量份混合而得到的物质,并投入至无缝胶囊制造装置中,使用同心三重喷嘴,将胶囊内容物的温度设为10℃,将胶囊覆膜液、中间层的温度设为60℃,喷出至流动的中链脂肪酸甘油三酯(约30℃)中,制造胶囊。接着,对该胶囊进行干燥(25℃、湿度为50%RH以下)处理,得到粒径为3.5mm的无缝胶囊。表1也记载了中间层和胶囊内容物的组成和各自的液温、冷却液的液温。
测定所得干燥无缝胶囊的直径D(mm)和覆膜厚度T(μm),且计算覆膜率,将结果示于表2。干燥无缝胶囊的直径D(mm)利用游标卡尺,关于覆膜厚度T(μm),将胶囊对半切割,并利用数字显微镜(キーエンス公司(制)デジタルマイクロスコープvhd-5000),每一球测定5个点,取其平均值来进行测定。
将所得的各个干燥无缝胶囊刚刚在25℃且湿度为60%RH的环境下暴露2小时后的无缝胶囊的破坏所需的载荷x(N)和破坏时位移y(mm)、以及刚刚在60℃且湿度为90%RH环境下暴露2小时后的无缝胶囊的破坏所需的载荷X(N)和破坏时位移Y(mm)如下获得:使用综合物性测定装置(サン科学公司制、流变仪),按压直径10mm的圆形柱塞,以20mm/min的基台速度进行评价。将针对同一规格的20个胶囊而测得的平均断裂强度x(N)=Σn=1 20xn/20、X(N)=Σn=1 20Xn/20、位移的平均值y(mm)=Σn=1 20yn/20、Y(mm)=Σn=1 20Yn/20、XY/xy、X/x、Y/y记载于表2。
用手指抓住所得无缝胶囊,刚刚在60℃且湿度为90%RH环境下暴露2小时后,用手指施加力时,容易发出清脆的声音而碎裂,可享受所得无缝胶囊的碎裂音和触感。另外,也可享受薄荷脑的香气。表2中,按照以下的评价基准来记载作为“音”的碎裂状态。
○:音调高、音的振幅大
△:音调低、音的振幅小
×:没有声音
实施例2~7
除了将覆膜层、中间层和胶囊内容物的组成设为表1所示组成之外,与实施例1同样地制作无缝胶囊。针对所得胶囊,与实施例1同样地测定D(mm)、T(μm)、覆膜率、x(N)、y(mm)、X(N)、Y(mm),求出XY/xy、X/x和Y/y。将其结果记载于表2。另外,关于碎裂音和触感,也与实施例1同样地测定,在表2中记载“音”的评价。
实施例8
使用实施例1的覆膜液,将作为胶囊内容物液的柠檬油122重量份、中链脂肪酸甘油三酯532重量份、蔗糖乙酸酯异丁酸酯264重量份混合,使用同心双重喷嘴,将覆膜液加热至82℃,用25℃的内容液来制造胶囊。接着,对该胶囊进行干燥(25℃、湿度为50%RH以下)处理,得到无缝胶囊。针对所得无缝胶囊,与实施例1同样地测定D(mm)、T(μm)、覆膜率、x(N)、y(mm)、X(N)、Y(mm),求出XY/xy、X/x和Y/y。将其结果记载于表2。将所得无缝胶囊刚刚在60℃、湿度为90%RH环境下暴露于2小时后抓住,用手指施加力时,呈现仅发出沉闷音的结果,在表2中,“音”的评价为△。
[表1]
[表2]
实施例9
作为胶囊内容物液,使用对纯化水745重量份添加羧甲基纤维素4重量份而使其溶解后,添加甘油216重量份、对羟基苯甲酸丙酯10重量份、柠檬香料25重量份并使其充分悬浮而得到的物质,作为中间层,使用将蜂蜡450重量份、固化油脂320重量份、蔗糖乙酸酯异丁酸酯200重量份、大豆卵磷脂30重量份在80℃下溶解而得到的物质,覆膜液使用表3中记载的物质,使用同心三重喷嘴,将覆膜液加热至82℃,利用60℃的中间层、10℃的内容液来制造胶囊。接着,对该胶囊进行干燥(25℃、湿度为50%RH以下)处理,得到无缝胶囊。针对所得无缝胶囊,与实施例1同样地测定D(mm)、T(μm)、覆膜率、x(N)、y(mm)、X(N)、Y(mm),求出XY/xy、X/x和Y/y。将其结果记载于表4。将所得无缝胶囊在刚刚在60℃、湿度为90%RH的环境下暴露2小时后抓住,用手指施加力时,另外,针对碎裂音和触感,也与实施例1同样地测定,在表4中记载“音”的评价。
实施例10~16
将表3的覆膜层一栏记载的重量份的脱酰化结冷胶、氯化钙、氧化淀粉、蜂蜡和蓝色一号与纯化水混合,在95℃下溶解并静置脱泡,制作胶囊覆膜液。胶囊内容物液、作为中间层的表3中记载的混合液使用与实施例9同样制备的物质,使用同心三重喷嘴,保持表3中记载的各喷出液的温度来制造胶囊。接着,对该胶囊进行干燥(25℃、湿度为50%RH以下)处理,得到无缝胶囊。针对所得无缝胶囊,与实施例1同样地测定D(mm)、T(μm)、覆膜率、x(N)、y(mm)、X(N)、Y(mm),求出XY/xy、X/x和Y/y。将其结果记载于表4。将所得无缝胶囊在刚刚在60℃、湿度为90%RH的环境下暴露2小时后抓住,用手指施加力时,另外,针对碎裂音和触感,也与实施例1同样地进行测定,在表4中记载“音”的评价。
[表3]
[表4]
附图标记说明
1…胶囊内容物
2…中间层
3…覆膜层
4…无缝胶囊
A…喷嘴截面
B…无缝胶囊喷流
11…内侧喷嘴
12…中间喷嘴
13…外侧喷嘴
14…胶囊核溶液
15…中间层溶液
16…最外层溶液
17…三层结构无缝胶囊
18…冷却液
Claims (16)
1.无缝胶囊,其包含胶囊内容物和覆盖该胶囊内容物的覆膜层,所述无缝胶囊的特征在于,
前述覆膜层至少包含脱酰基型结冷胶和修饰淀粉,
前述胶囊内容物包含油性成分。
2.根据权利要求1所述的无缝胶囊,其中,前述覆膜层以按照覆膜重量基准计为70重量%以上且98.5重量%以下的量包含脱酰基型结冷胶,以按照覆膜重量基准计为0.01重量%以上且30重量%以下的量包含修饰淀粉。
3.根据权利要求1或2所述的无缝胶囊,其特征在于,前述覆膜层还包含结晶纤维素。
4.根据权利要求1~3中任一项所述的无缝胶囊,其特征在于,前述无缝胶囊的粒径为0.5~8.0mm,并且,覆膜率为5%以上且40%以下。
5.根据权利要求1~4中任一项所述的无缝胶囊,其中,前述修饰淀粉为氧化淀粉。
6.根据权利要求1~5中任一项所述的无缝胶囊,其中,前述胶囊内容物中的油状成分包含香料。
7.根据权利要求1~6中任一项所述的无缝胶囊,其中,前述香料为选自留兰香、薄荷脑、薄荷、柑橘、柚子、玫瑰、柠檬、葡萄柚、金橘、桃子、苹果、香蕉、菠萝、葡萄、芒果、热带水果、蓝莓、蔓越橘、红豆越橘、美洲越橘、木莓、黑莓、洛根莓、美莓、博伊森树莓、草莓、欧洲越橘、接骨木果和醋栗中的至少一种。
8.根据权利要求1~7中任一项所述的无缝胶囊,其中,前述无缝胶囊为胶囊内容物与覆膜层的两层结构、或者在胶囊内容物与覆膜层之间具有中间层的三层结构。
9.根据权利要求1~8中任一项所述的无缝胶囊,其特征在于,将前述无缝胶囊在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的载荷记作X(N),将破坏时位移记作Y(mm),同样地将前述无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的载重记作x(N),将破坏时位移记作y(mm)时,XY/xy的值处于0.76以上且1.15以下的范围内。
10.根据权利要求1~8中任一项所述的无缝胶囊,其特征在于,将前述无缝胶囊在60℃且相对湿度为90%RH的条件下保存60分钟后,朝着最小粒径方向按压而被破坏所需的载荷记作X(N),将破坏时位移记作Y(mm),同样地将前述无缝胶囊在25℃且相对湿度为60%RH的条件下保存120分钟后,朝着最小粒径方向按压而被破坏所需的载重记作x(N),将破坏时位移记作y(mm)时,XY/xy的值处于0.76以上且1.32以下的范围内。
11.权利要求1所述的无缝胶囊的制造方法,其为利用滴加法来制造无缝胶囊的方法,所述滴加法中,将从内侧喷嘴和外侧喷嘴以同心圆状存在的双重喷嘴同时喷出的喷出液滴加至冷却液中,所述制造方法的特征在于,
从内侧喷嘴喷出胶囊内容物液,
从外侧喷嘴喷出覆膜层液,
前述胶囊内容物液包含油性成分,且将胶囊内容物液的温度在5℃~30℃的范围内控制至设定值±2℃,
前述覆膜层液至少包含脱酰基型结冷胶和修饰淀粉,且将覆膜层液的温度在60℃~90℃的范围内控制至设定值±2℃,
前述冷却液包含油,且将冷却液的温度在10℃~30℃的范围内控制至设定值±2℃,
前述覆膜层液的温度与前述冷却液的温度之差控制至30℃以上且80℃以下的范围。
12.权利要求1所述的无缝胶囊的制造方法,其为利用滴加法来制造无缝胶囊的方法,所述滴加法中,将从内侧喷嘴、中间喷嘴和外侧喷嘴以同心圆状存在的三重喷嘴同时喷出的喷出液滴加至冷却液中,所述制造方法的特征在于,
从内侧喷嘴喷出胶囊内容物液,
从中间喷嘴喷出中间层液,
从外侧喷嘴喷出覆膜层液,
前述胶囊内容物液包含油性成分,且将胶囊内容物液的温度在5℃~30℃的范围内控制至设定值±2℃,
将前述中间层液的温度在40~85℃的范围内控制为设定值±2℃,
前述覆膜层液至少包含脱酰基型结冷胶和修饰淀粉,且将覆膜层液的温度在60℃~90℃的范围内控制为设定值±2℃,
前述冷却液包含油,且将冷却液的温度在10℃~30℃的范围内控制为设定值±2℃,
将前述覆膜层液的温度与前述冷却液的温度之差控制为30℃以上且80℃以下的范围。
13.根据权利要求11或12所述的无缝胶囊的制造方法,其中,前述修饰淀粉为氧化淀粉。
14.根据权利要求11~13中任一项所述的无缝胶囊的制造方法,其特征在于,前述覆膜层还包含结晶纤维素。
15.根据权利要求11~14中任一项所述的无缝胶囊的制造方法,其中,前述胶囊内容物液中的油状成分包含香料。
16.根据权利要求11~15中任一项所述的无缝胶囊的制造方法,其中,前述香料为选自留兰香、薄荷脑、薄荷、柑橘、柚子、玫瑰、柠檬、葡萄柚、金橘、桃子、苹果、香蕉、菠萝、葡萄、芒果、热带水果、蓝莓、蔓越橘、红豆越橘、美洲越橘、木莓、黑莓、洛根莓、美莓、博伊森树莓、草莓、欧洲越橘、接骨木果和醋栗中的至少一种。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2021061495 | 2021-03-31 | ||
JP2021-061495 | 2021-03-31 | ||
PCT/JP2022/016185 WO2022210939A1 (ja) | 2021-03-31 | 2022-03-30 | 高温多湿環境でも安定して崩壊可能なシ-ムレスカプセルおよびその製造方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN117120042A true CN117120042A (zh) | 2023-11-24 |
Family
ID=82929889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202280026256.2A Pending CN117120042A (zh) | 2021-03-31 | 2022-03-30 | 即便在高温多湿环境下也能够稳定崩解的无缝胶囊及其制造方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20240180219A1 (zh) |
EP (1) | EP4316472A1 (zh) |
JP (2) | JP7122495B1 (zh) |
KR (1) | KR20230163395A (zh) |
CN (1) | CN117120042A (zh) |
BR (1) | BR112023017615A2 (zh) |
CA (1) | CA3211920A1 (zh) |
MX (1) | MX2023011551A (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7372714B1 (ja) | 2022-11-01 | 2023-11-01 | 富士カプセル株式会社 | 水封入カプセル及びその製造方法 |
JPWO2024096059A1 (zh) * | 2022-11-01 | 2024-05-10 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005170929A (ja) * | 2003-11-18 | 2005-06-30 | Showa Sangyo Co Ltd | ソフトカプセル基剤 |
EP1721619A4 (en) | 2004-02-17 | 2012-09-05 | Eisai R&D Man Co Ltd | PREPARATION FOR FLEXIBLE CAPSULE |
US7494667B2 (en) * | 2004-03-02 | 2009-02-24 | Brunob Ii B.V. | Blends of different acyl gellan gums and starch |
WO2007012981A2 (en) * | 2005-06-21 | 2007-02-01 | V. Mane Fils | Gellan seamless breakable capsule and process for manufacturing thereof |
US20070034827A1 (en) * | 2005-12-02 | 2007-02-15 | Zhixin Li | Blends of gelling and non-gelling starches with gellan gums and plasticizer |
JP2009040716A (ja) * | 2007-08-08 | 2009-02-26 | Oyo Seikagaku Kenkyusho | 軟カプセル皮膜組成物 |
-
2022
- 2022-03-30 CN CN202280026256.2A patent/CN117120042A/zh active Pending
- 2022-03-30 JP JP2022525269A patent/JP7122495B1/ja active Active
- 2022-03-30 BR BR112023017615A patent/BR112023017615A2/pt unknown
- 2022-03-30 CA CA3211920A patent/CA3211920A1/en active Pending
- 2022-03-30 KR KR1020237032625A patent/KR20230163395A/ko unknown
- 2022-03-30 EP EP22781149.4A patent/EP4316472A1/en active Pending
- 2022-03-30 MX MX2023011551A patent/MX2023011551A/es unknown
- 2022-03-30 US US18/552,544 patent/US20240180219A1/en active Pending
- 2022-08-05 JP JP2022125336A patent/JP2022159397A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2022159397A (ja) | 2022-10-17 |
EP4316472A1 (en) | 2024-02-07 |
BR112023017615A2 (pt) | 2023-10-10 |
KR20230163395A (ko) | 2023-11-30 |
CA3211920A1 (en) | 2022-10-06 |
US20240180219A1 (en) | 2024-06-06 |
MX2023011551A (es) | 2023-10-10 |
JPWO2022210939A1 (zh) | 2022-10-06 |
JP7122495B1 (ja) | 2022-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN113316398B (zh) | 无缝胶囊以及包含其的过滤器和吸烟器具 | |
JP7064466B2 (ja) | 崩壊可能なカプセル及びその製造方法並びに崩壊可能なカプセルを含む喫煙器具 | |
CN117120042A (zh) | 即便在高温多湿环境下也能够稳定崩解的无缝胶囊及其制造方法 | |
JP2010530240A (ja) | 押出デリバリーシステム | |
JP2012526547A (ja) | 顆粒状のデリバリーシステム | |
CA3119497C (en) | High amylose starch based capsules and method of making same | |
JP2020115848A (ja) | シ−ムレスカプセルならびにこれを含むフィルターおよび喫煙器具 | |
WO2022210939A1 (ja) | 高温多湿環境でも安定して崩壊可能なシ-ムレスカプセルおよびその製造方法 | |
Sánchez-Vega et al. | Opuntia spp. Products and by-products as a potential source of edible films and coatings | |
US20040180068A1 (en) | Cellulose-based particles or liquids and methods for their preparation and use | |
RU2774539C1 (ru) | Бесшовная капсула, а также фильтр и курительное оборудование, включающие в себя такую капсулу | |
EP4420534A1 (en) | Smokeless tobacco product for oral use and soft capsule used therein |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 40100332 Country of ref document: HK |