CN117119884A - Virus inactivating composition for liquid spray - Google Patents
Virus inactivating composition for liquid spray Download PDFInfo
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- CN117119884A CN117119884A CN202280028430.7A CN202280028430A CN117119884A CN 117119884 A CN117119884 A CN 117119884A CN 202280028430 A CN202280028430 A CN 202280028430A CN 117119884 A CN117119884 A CN 117119884A
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- 239000000203 mixture Substances 0.000 title claims abstract description 143
- 239000007921 spray Substances 0.000 title claims abstract description 58
- 230000000415 inactivating effect Effects 0.000 title claims abstract description 41
- 239000007788 liquid Substances 0.000 title claims abstract description 26
- 238000009835 boiling Methods 0.000 claims abstract description 273
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- 238000000034 method Methods 0.000 claims abstract description 52
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention provides a liquid spray virus inactivating composition and a virus inactivating method capable of inactivating viruses existing in the environment. The present invention relates to a virus inactivation method, which is characterized in that a composition containing A1) 40-90 mass% of glycol with a boiling point below 220 ℃ and a carbon number of 2-4 and 10-60 mass% of water is sprayed on the surface of an object which is worry of virus pollution.
Description
Technical Field
The invention relates to a virus inactivation composition for liquid spraying and a virus inactivation method.
Prior Art
Viral infections cause severe symptoms such as pneumonia, hepatitis, and encephalitis, which are typical of common cold symptoms, and are a permanent threat to humans. In recent years, influenza viruses have been abused worldwide, and sometimes pandemic is caused by the occurrence of new influenza with antigenic changes. In addition, SARS coronavirus-2 (SARS-CoV-2) appeared in 2019, which caused pandemic, and not only affected life and health, but also economic activity and social function.
Viruses are an infection that is amplified by contact infection of a finger or various instruments/members, coughing or sneezing, infection of droplets caused by direct inhalation of droplets generated by conversation, or infection of air caused by inhalation of nuclei of droplets floating in the air. Therefore, it is widely considered that in order to prevent the spread of infection, it is effective to remove or inactivate viruses and inactivate viruses that splash or float in a space by cleaning or sterilizing an object to which viruses may be attached.
(patent document 1) Japanese patent application laid-open No. 4-502616
Disclosure of Invention
The present invention relates to the following 1) to 3).
1) A virus-inactivating composition for liquid spray comprising A1) 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 and 10 to 60 mass% of water.
2) A method for inactivating viruses, which comprises spraying a composition containing A1) 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 and 10 to 60 mass% of water onto a hard or soft surface of an inanimate object or a waste which is concerned about contamination with viruses.
3) A method for inactivating viruses in a subject space, comprising spraying a composition containing 40 to 90 mass% of a glycol having a boiling point of A1) at or below 220 ℃ and a carbon number of 2 to 4 and 10 to 60 mass% of water onto a carrier, and evaporating the composition from the carrier so that the concentration of the glycol having a boiling point of A1) at or below 220 ℃ and a carbon number of 2 to 4 in the space becomes 20ppm or more.
Detailed Description
Conventionally, ethanol, sodium hypochlorite, chlorine dioxide, glutaraldehyde, and the like have been used for inactivating viruses. However, these agents have a high irritation to mucous membranes and skin, and therefore have limited uses due to safety problems and fear of allergy. In particular, it is not suitable for the use of a nebulizer to inactivate viruses. For example, the use of ethanol for the sterilization of a work space in a vehicle such as an automobile (garbage truck, bus, etc.), an electric car, or an airplane is limited because of the risk of ignition. In addition, as a method for chemically inactivating viruses existing in a space, spraying chlorine dioxide has been studied, but the effect thereof has not been confirmed.
Diols having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 are one of polyols, and are used in solvents, antifreeze, lubricating oils, pharmaceuticals, and the like. For example, patent document 1 discloses a virucidal liquid composition containing glutaraldehyde and glycol such as propylene glycol for reducing odor thereof in an amount of about 10 to 20% by weight. As described in patent document 1, it is reported that diols having a boiling point of 220 ℃ or lower, such as propylene glycol, and having 2 to 4 carbon atoms have an inactivating effect on influenza viruses and the like.
However, since a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 is a viscous liquid, it cannot be sprayed to inactivate viruses, and thus there has been no known antiviral agent for spraying which uses a virus inactivating effect of a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4.
The present invention relates to a virus inactivation composition for liquid spray and a virus inactivation method, which can inactivate viruses existing in the environment.
The present inventors have found that a composition having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 and a specific concentration of each of a glycol and a water can be sprayed, and that a virus inactivating effect can be exhibited by a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4. It has been found that alkyl glyceryl ether and a specific perfume have an effect of inactivating viruses, and that the virus inactivating effect is improved by combining these with a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4.
According to the present invention, it is possible to inactivate viruses attached to objects in living environments or viruses in spaces and prevent or reduce the spread of infection caused by the viruses.
The virus-inactivating composition for liquid spray of the present invention (hereinafter also referred to as composition) contains A1) a diol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4. In the composition of the present invention, a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 is preferably used as the virus-inactivating active ingredient.
In the present invention, the boiling point means an initial boiling point at 1 atmosphere or a temperature range in a boiling state.
Examples of the diols having a boiling point of 220℃or lower and a carbon number of 2 to 4 include:
ethylene glycol (boiling point 197 ℃ C.),
1, 2-propanediol (boiling point 188 ℃ C.), and,
1, 3-propanediol (boiling point 213 ℃ C.), and,
1, 2-butanediol (boiling point 192 ℃ C.), a catalyst,
1, 3-butanediol (boiling point 207 ℃ C.), and
2, 3-butanediol (boiling point 177 ℃).
Among these, 1, 2-propanediol (boiling point 188 ℃) is preferable, 2, 3-butanediol (boiling point 177 ℃), 1, 2-butanediol (boiling point 192 ℃) and ethylene glycol (boiling point 197 ℃) are more preferable from the viewpoint of easy evaporation after spraying of the liquid, and 1, 2-propanediol (boiling point 188 ℃) is more preferable from the viewpoint of less odor.
The composition of the present invention preferably contains, in addition to the above-mentioned A1) glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4, A2) glycol ether having a boiling point of 220 ℃ or less and a carbon number of 6. The content of A2) in the composition is 50% by mass or less, and the total amount of A1) and A2) exceeds 40% by mass and is 90% by mass or less.
Examples of the glycol ether having a boiling point of 220℃or lower and a carbon number of 6 include diethylene glycol monoethyl ether (alias ethyl carbitol, ethyl diethylene glycol, boiling point 202 ℃), and ethylene glycol monobutyl ether (alias butyl cellosolve, boiling point 171 ℃). Among them, diethylene glycol monoethyl ether is preferable from the viewpoint of less odor.
From the viewpoints of lowering the viscosity of the composition and facilitating spraying, and, in the case of containing a perfume, facilitating solubilizing the perfume, and improving the aroma-indicating property and antiviral effect by the perfume, A2) in the composition has a boiling point of 220 ℃ or less and a content of glycol ether having 6 carbon atoms of preferably 1 mass% or more, more preferably 3 mass% or more, and still more preferably 7 mass% or more. From the viewpoint of reducing the damaging property of the base material of the object for spraying, it is preferably 40% by mass or less, more preferably 30% by mass or less, further preferably 20% by mass or less, further preferably 15% by mass or less, and further preferably 10% by mass or less. In the present invention, the indication of the fragrance means that the fragrance is easily recognized and the disappearance thereof is easily known as an indicator of whether or not the fragrance is sprayed.
From the viewpoints of lowering the viscosity of the composition and facilitating spraying, and in the case of containing a perfume, facilitating solubilizing the perfume, and improving the aroma-indicating property and antiviral effect of the perfume, the mass ratio [ A2)/(A1) +a2) ] of A2) glycol ether having a boiling point of 220 ℃ or lower and a carbon number of 6 to A1) glycol ether having a boiling point of 220 ℃ or lower and a carbon number of 2 to A2) glycol ether having a boiling point of 220 ℃ or lower and a carbon number of 6 is preferably 0.05 or more, more preferably 0.1 or more, and further preferably 0.15 or more. In addition, from the viewpoint of reducing the base material damage of the object for spraying, it is preferably 1.0 or less, more preferably 0.5 or less, and further preferably 0.3 or less.
The composition of the present invention preferably further contains A3) an alkyl glyceryl ether from the viewpoint of reducing viscosity and from the viewpoint of inactivating viruses.
Examples of the alkyl glyceryl ether include alkyl glyceryl ethers having one alkyl group having 8 to 18 carbon atoms, preferably 8 to 14 carbon atoms, more preferably 8 to 12 carbon atoms, and still more preferably 8 to 10 carbon atoms. Examples of the "alkyl" may include a straight-chain alkyl group and a branched-chain alkyl group, and preferably a branched-chain alkyl group, more preferably a 2-ethylhexyl group, an isononyl group or an isodecyl group, and further preferably a 2-ethylhexyl group.
Among these, the alkyl glyceryl ether is preferably an alkyl glyceryl ether having one branched alkyl group having 8 to 12 carbon atoms, more preferably an alkyl glyceryl ether having one branched alkyl group having 8 carbon atoms, and still more preferably 2-ethylhexyl glyceryl ether.
The content of A3) alkyl glyceryl ether in the composition is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, further preferably 0.4% by mass or more, from the viewpoint of reducing viscosity and virus inactivation, and is preferably 2% by mass or less, more preferably 1% by mass or less, further preferably 0.9% by mass or less, further preferably 0.8% by mass or less, from the viewpoint of reducing irritation upon contact with a human body after spraying.
From the viewpoint of reducing the viscosity, the mass ratio [ A3)/A1) ] of the alkyl glyceryl ether of A3) to the glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 in the composition is preferably 0.001 or more, more preferably 0.005 or more, further preferably 0.01 or more, and from the viewpoint of reducing the irritation at the time of contact with a human body after spraying, is preferably 0.1 or less, more preferably 0.05 or less, further preferably 0.04 or less, further more preferably 0.03 or less.
The composition of the present invention preferably further contains a fragrance (in addition to the above-mentioned diol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4) as an indicator for judging whether or not spraying has been performed. The aroma indicator is an aroma that can be recognized when sprayed, but does not remain aroma for a long time, and is an indicator of whether or not an object has been sprayed.
From the viewpoint of indication, the boiling point of the perfume is preferably 120 ℃ to 260 ℃, more preferably 130 ℃ to 220 ℃, and even more preferably 140 ℃ to 220 ℃. In the present invention, the indication of the fragrance means that the fragrance is easily recognized and the disappearance thereof is easily known.
Examples of the perfume include: hydrocarbons, aldehydes, ketones, alcohols, phenols, lactones, esters, ethers, thiols, and the like. Among them, monoterpene hydrocarbons, aldehydes, alcohols, and esters are preferable from the viewpoint of pleasant quality of aroma and a large number of low-threshold compounds. These may be used alone or in combination of 2 or more.
Here, a low-threshold compound is preferable because the flavor can be perceived even in a small amount.
Examples of suitable monoterpene hydrocarbons include limonene (boiling point 177 ℃). The limonene can be used in the form of essential oil containing more limonene, lemon oil, orange oil, grapefruit oil, bergamot oil, grapefruit oil, etc.
Examples of suitable aldehydes, alcohols and esters include compounds represented by the following general formula (I).
R 1 -A(I)
(wherein R is 1 Represents a hydrocarbon group having 4 to 10 carbon atoms which may have a substituent; a represents a hydroxyl group or any one of the structures of the following (a) or (b);
R 2 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms. )
In the general formula (I), R is 1 Examples of the "hydrocarbon group having 4 to 10 carbon atoms" may include an aliphatic hydrocarbon group and an aromatic hydrocarbon group. The aliphatic hydrocarbon group may be any of linear, branched or cyclic, or may be saturated or unsaturatedAny one of saturation.
The saturated aliphatic hydrocarbon group may be a linear, branched or cyclic saturated aliphatic hydrocarbon group, and examples thereof include: alkyl groups such as n-butyl, isobutyl, sec-butyl, tert-butyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl and the like; cycloalkyl groups such as cyclobutyl, cyclopentyl, cyclohexyl, 2-isopropyl-5-methylcyclohexyl (menthyl), cycloheptyl, cyclooctyl, cyclononyl, and cyclodecyl.
The unsaturated aliphatic hydrocarbon group represents a linear, branched or cyclic unsaturated aliphatic hydrocarbon group having 1 or 2 or more double bonds in the molecule, and examples thereof include: alkenyl groups such as n-butenyl, isobutenyl, pentenyl, hexenyl, heptenyl, octenyl, 3, 7-dimethyl-6-octenyl, nonenyl, decenyl and the like; cycloalkenyl such as cyclobutenyl, cyclopentenyl, cyclohexenyl, 1-isopropyl-4-methyl-3-cyclohexenyl, and the like; alkadienyl groups such as butadienyl, pentadienyl, hexadienyl, heptadienyl, octadienyl, nonadienyl, decadienyl, 1, 5-dimethyl-1-vinyl-4-hexenyl, and 3, 7-dimethyl-2, 6-octadienyl (geranyl).
Examples of the aromatic hydrocarbon group include: aryl groups such as phenyl; aralkyl groups such as benzyl and phenethyl; styryl, phenylallyl (cinnamyl), and the like.
The substituent which may be substituted on the hydrocarbon group having 4 to 10 carbon atoms may preferably be an alkoxy group having 1 to 3 carbon atoms. The alkoxy group having 1 to 3 carbon atoms represents a linear or branched alkoxy group having 1 to 3 carbon atoms, and examples thereof include methoxy group, ethoxy group, n-propoxy group, and isopropoxy group.
In the general formula (I), R 2 The alkyl group having 1 to 3 carbon atoms represented by the formula (I) represents a linear, branched or cyclic alkyl group having 1 to 3 carbon atoms, and examples thereof include methyl, ethyl, n-propyl, isopropyl and cyclopropyl.
From the viewpoint of virus inactivation and the viewpoint of a large number of low-threshold compounds, a suitable perfume of the present invention is a compound represented by the general formula (I), wherein R 1 Is alkyl or alkenyl with 4-10 carbon atoms; a represents a hydroxyl group or is any of the structures of (a) or (b) above; r is R 2 A compound which is a hydrogen atom or a methyl group.
From the viewpoint of aroma indication, a more suitable perfume of the present invention is a perfume having a boiling point in the range of 120 ℃ to 260 ℃.
Examples of fragrances having boiling points of 120℃to 130 ℃):
Isoamyl formate (boiling point 123 ℃), butyl acetate (boiling point 126 ℃), cis-3-hexenal (boiling point 126 ℃), and the like.
Examples of fragrances having boiling points in excess of 130℃to 140 ℃):
3-methyl-1-butanol (isoamyl alcohol, boiling point 132 ℃), 1-pentanol (n-pentanol, boiling point 138 ℃), and the like.
Examples of fragrances having boiling points in excess of 140℃to 180 ℃):
isoamyl acetate (boiling point 142 ℃), trans-2-hexenal (boiling point 146 ℃), cis-3-hexenal formate (boiling point 155 ℃), hexyl formate (boiling point 155 ℃), trans-3-hexenol (boiling point 155 ℃), cis-3-hexenol (boiling point 156 ℃), hexanol (boiling point 156 ℃), trans-2-hexenol (boiling point 159 ℃), trimethylhexanal (3, 5-trimethylhexanal, boiling point 167 ℃), cis-3-hexenal acetate (boiling point 169 ℃), dimet (registered trademark, 2, 4-dimethyl-2-heptanol, boiling point 170 ℃), hexyl acetate (boiling point 172 ℃), 3-methyl-3-methoxybutanol (boiling point 174 ℃), heptanol (boiling point 175 ℃), limonene (boiling point 177 ℃), isoamyl butyrate (boiling point 178 ℃), benzaldehyde (boiling point 178 ℃), and the like.
Examples of perfumes having a boiling point of more than 180 to 220 ℃ or less:
MELONAL (2, 6-dimethyl-5-heptenal, boiling point 188 ℃), cycloevertal (registered trademark, 3, 6-dimethyl-3-cyclohexene-1-carbaldehyde, boiling point 189 ℃), trimethylhexanol (3, 5-trimethylhexanol, boiling point 193 ℃), dihydromyrcenol (boiling point 194 ℃), linalool (boiling point 199 ℃), linalool formate (boiling point 202 ℃), benzyl alcohol (boiling point 205 ℃), benzyl acetate (boiling point 212 ℃), dimethylbenzyl alcohol (2-methyl-1-phenylpropane-2-ol, boiling point 215 ℃), geranyl formate (boiling point 216 ℃), phenethyl alcohol (boiling point 219 ℃), linalyl acetate (boiling point 220 ℃), and solanum nigrum alcohol (hydratropic alchol, 2-phenylpropanol, boiling point 220 ℃), and the like.
Examples of perfumes having a boiling point of 220 to 260 ℃ or lower:
syringaldehyde (2- (4- (methylphenyl) acetaldehyde) (boiling point 221 ℃), phenylpropionaldehyde (boiling point 222 ℃), nightmaral (2-phenylpropionaldehyde, boiling point 222 ℃), phenylethyl formate (boiling point 226 ℃), geraniol (boiling point 230 ℃), citronellyl formate (boiling point 235 ℃), alloocimene alcohol (Mugul) (3, 7-dimethyl-4, 6-octadien-3-ol, boiling point 237 ℃), methoxy citronellal (boiling point 238 ℃), geranyl acetate (boiling point 245 ℃), cinnamyl formate (boiling point 250 ℃), cinnamyl formate (boiling point 252 ℃), and the like.
As the boiling point value of the perfume, the value of HP http:// www.thegoodscentscompany.com/760 mmhg of Good Scent Company can be used, and the values are not described in https:// www.chemsrc.com/en/, http:// www.chemspider.com/, chemical industry daily news of the new edition of the chemical and commercial knowledge supplement, 2016.
As more suitable perfumes, as perfumes having a boiling point in the range of 120 ℃ to 220 ℃, there can be exemplified: the formate isovaleryl ester (boiling point 123 ℃), butyl acetate (boiling point 126 ℃), cis-3-hexenal (boiling point 126 ℃), 3-methyl-1-butanol (isoamyl alcohol, boiling point 132 ℃), 1-pentanol (n-pentanol, boiling point 138 ℃), isoamyl acetate (boiling point 142 ℃), trans-2-hexenal (boiling point 146 ℃), cis-3-hexeneformate (boiling point 155 ℃), hexyl formate (boiling point 155 ℃), trans-3-hexeneol (boiling point 155 ℃), cis-3-hexeneol (boiling point 156 ℃), hexanol), trans-2-hexeneol (boiling point 159 ℃), trimethylaldol (3, 5-trimethylaldol, boiling point 167 ℃), cis-3-hexeneacetate (boiling point 169 ℃), dimet-time 172 ℃), 3-methyl-3-methoxybutanol (174 ℃), heptanol (175 ℃), heptene (177 ℃), limonene (177 ℃), isopentenyl butyrate) (boiling point 178 ℃), benzaldehyde (boiling point 178 ℃), meclov), and butyl alcohol (meclov 188), linalool (boiling point 156), linalool (boiling point 193), linalool (202), linalool (aromatic alcohol (boiling point 193), linalool) Benzyl acetate (boiling point 212 ℃), dimethylbenzyl alcohol (boiling point 215 ℃), geranyl formate (boiling point 216 ℃), phenethyl alcohol (boiling point 219 ℃), black nightshade alcohol (boiling point 220 ℃), and linalyl acetate (boiling point 220 ℃).
The composition of the present invention preferably contains a perfume that not only serves as a fragrance indicator but also has a virus inactivating effect. Further suitable fragrances from the standpoint of viral inactivation are as follows.
Isoamyl formate (boiling point 123 ℃),
butyl acetate (boiling point 126 ℃ C.),
3-methyl-1-butanol (boiling point 132 ℃ C.),
1-pentanol (boiling point 138 ℃ C.),
isoamyl acetate (boiling point 142 ℃ C.),
trans-2-hexenal (boiling point 146 ℃),
cis-3-hexenyl formate (boiling point 155 ℃ C.), and,
Trans-3-hexenol (boiling point 155 ℃ C.), and,
Cis-3-hexenol (boiling point 156 ℃ C.), and,
Hexanol (boiling point 156 ℃ C.),
trans-2-hexenol (boiling point 159 ℃ C.), and,
3, 5-trimethylhexanal (trimethylhexanal) (boiling point 167 ℃ C.), and,
2, 4-dimethyl-2-heptanol (dimet al, boiling point 170 ℃ C.), and,
3-methyl-3-methoxybutanol (boiling point 174 ℃ C.),
heptanol (boiling point 175 ℃ C.),
benzaldehyde (boiling point 178 ℃),
2, 6-dimethyl-5-heptenal (MELONAL) (boiling point 188 ℃ C.), and,
3, 6-dimethyl-3-cyclohexene-1-carbaldehyde (Cycloevertal) (boiling point 189 ℃ C.), and,
3, 5-trimethylhexanol (trimethylhexanol) (boiling point 193 ℃ C.), and,
Dihydromyrcenol (boiling point 194 ℃),
linalyl formate (boiling point 202 ℃ C.), and,
Benzyl alcohol (boiling point 205 ℃),
benzyl acetate (boiling point 212 ℃ C.), and,
2-methyl-1-phenylpropane-2-ol (dimethylbenzyl alcohol) (boiling point 215 ℃ C.), phenethyl alcohol (boiling point 219 ℃ C.), and,
2-phenylpropanol (solanol) (boiling point 220 ℃ C.), and,
Phenylpropionaldehyde (boiling point 222 ℃ C.),
solanum nigrum aldehyde (boiling point 222 ℃),
phenyl ethyl formate (boiling point 226 ℃ C.),
3, 7-dimethyl-4, 6-octadien-3-ol (Mugul) (boiling point 237 ℃ C.), and,
Citronellyl formate (boiling point 235 ℃), and,
Methoxy citronellal (boiling point 238 ℃),
cinnamic alcohol (boiling point 250 ℃ C.),
cinnamyl formate (boiling point 252 ℃).
From the viewpoint of aroma-indicating property and virus inactivation, the composition of the present invention preferably contains a perfume having a boiling point of 120 ℃ to 260 ℃ in a range of preferably 0.001 to 1.0 mass%, more preferably 0.01 to 0.5 mass%.
The composition may also contain other fragrances (fragrances having boiling points of less than 120 ℃ or exceeding 260 ℃) in an amount of preferably 0.5 mass% or less, more preferably 0.1 mass% or less. In the composition, the proportion of the perfume having a boiling point of 120 ℃ to 260 ℃ is preferably 90% by mass or more, more preferably 95% by mass or more, based on the total perfume.
Further, in the composition of the present invention, the ratio of the perfume having a boiling point of 120 ℃ to 260 ℃ relative to A1) the diol having a boiling point of 220 ℃ or less and having 2 to 4 carbon atoms (perfume/diol having a boiling point of 220 ℃ or less and having 2 to 4 carbon atoms) is preferably 0.00001 to 0.1, more preferably 0.0001 to 0.01.
In addition to the above-mentioned components, the composition of the present invention may contain additives such as viscosity modifiers such as ethanol and isopropyl alcohol, nonvolatile antiviral and antibacterial agents such as benzalkonium chloride, dialkyldimethylammonium chloride, sodium hypochlorite, hypochlorous acid water, chlorous acid water, glutaraldehyde, surfactants (excluding benzalkonium chloride and dialkyldimethylammonium chloride), chelating agents, moisturizers, lubricants, auxiliaries, buffers, abrasives, electrolytes, bleaching agents, perfumes, dyes, foaming control agents, preservatives, essential oils, tackifiers, pigments, gloss enhancers, enzymes, lotions, dispersants, polymers, silicones, and hydrophilic substances, in a suitable combination, as far as the effects of the present invention are not impaired. The content of the additive may be appropriately set within a range that does not impair the object of the present invention, and it is preferable that the total content of the glycol having A1) boiling point of 220 ℃ or less and having 2 to 4 carbon atoms, water and the perfume in the composition is 80 mass% or more, and further 90 mass% or more. In particular, from the viewpoint of reducing the irritation to the human body during spraying, the non-volatile antiviral agent and the antibacterial agent are preferably not contained, and when contained, the content is preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 1% by mass or less, and preferably substantially none.
In the case of ethanol, it is preferably 10 mass% or less, more preferably 5 mass% or less, further preferably 1 mass% or less, and preferably substantially no ethanol is contained from the viewpoint of preventing ignition.
As shown in examples described later, A1) a composition having a boiling point of 220 ℃ or lower and a glycol having 2 to 4 carbon atoms and water each having a specific concentration range is suitable for spraying, and when the composition is sprayed to contact with influenza virus, the virus can be inactivated. Further, it was confirmed that alkyl glyceryl ether and a specific perfume have an effect of inactivating viruses, and that the combination of these with a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 improves the effect of inactivating viruses.
Therefore, a combination of a diol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4, and at least 1 selected from alkyl glyceryl ether and a specific perfume is useful as an active ingredient for virus inactivation, and is also useful for producing a virus-inactivated composition for liquid spraying.
Further, when a composition containing 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 and 10 to 60 mass% of water, or a composition containing 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4, 10 to 60 mass% of water, or at least 1 kind selected from alkyl glyceryl ether and a specific perfume is sprayed onto a subject suffering from viral contamination, the virus on the subject can be inactivated.
The content of the diol having A1) boiling point of 220 ℃ or less and a carbon number of 2 to 4 in the composition is 40 mass% or more, preferably 50 mass% or more, more preferably 60 mass% or more, still more preferably 70 mass% or more from the viewpoint of virus inactivation, and 90 mass% or less, preferably 80 mass% or less from the viewpoint of spray characteristics. The spray characteristics herein mean that the composition is less likely to remain in the discharge path in the container, and more of the formulation liquid is discharged to the object or space.
Examples of water include tap water, distilled water, ion-exchanged water, and purified water.
The water content in the composition is 10 mass% or more, preferably 20 mass% or more from the viewpoint of spray characteristics, and 60 mass% or less, preferably 50 mass% or less, more preferably 40 mass% or less from the viewpoint of virus inactivation.
From the viewpoint of virus inactivation and from the viewpoint of spray characteristics, it is preferable to mix and dissolve the glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 with water so as to achieve the concentration of the glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 and water in the above A1).
In the composition, from the viewpoint of virus inactivation, the mass ratio of the diol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 to water [ diol/water having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 ] is preferably 0.6 to 9.0, more preferably 1.0 to 4.0, still more preferably 1.5 to 4.0, and even more preferably 1.5 to 3.0, in terms of A1) ratio of the diol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 to water.
From the viewpoint of spray characteristics, the viscosity of the composition at 20℃is preferably 2 to 40 mPas, more preferably 3 to 20 mPas. The viscosity can be measured by means of an ultrasonic viscometer. In addition, in the case of use not involving ignition, ethanol or isopropanol may be contained as a viscosity adjuster, and in the case of containing these in the composition, the content thereof is preferably about 1 to 10% by mass in the composition.
The spraying amount of the composition is preferably in the range of 0.1g to 500 g/min, more preferably 10g to 500 g/min, still more preferably 20g to 100 g/min. In order to set the spray amount as described above, an atomizing nozzle is preferably used for a nebulizer. An atomizing device such as an atomizer (nebulizer) may be used to set the spray amount to 0.1 g/min to 1 g/min, and a dispersing device such as a cleaning nozzle or a sprayer may be used to set the spray amount to 50 g/min to 500 g/min.
Further, in the case of spraying in an enclosed space or a semi-enclosed space, the spraying amount is preferably 50g to 200g/m with respect to the target space 3 。
The range of the liquid pressure of the composition to be supplied to the sprayer nozzle is preferably 0.1MPa or more, more preferably 0.15MPa or more, from the viewpoint of easy spraying of the viscous liquid, and is preferably 2.5MPa or less, more preferably 0.7MPa or less, from the viewpoint of complete spraying.
The diameter of the passage of the foreign matter in the nozzle of the atomizer (the diameter of the largest sphere that can pass through the smallest flow path in the nozzle) is preferably 0.05mm or more, more preferably 0.1mm or more, further preferably 0.15mm or more, from the viewpoint of easy spraying of the viscous liquid, and preferably 0.5mm or less, more preferably 0.4mm or less, more preferably 0.3mm or less, from the viewpoint of complete spraying.
Viruses to be inactivated by the virus of the present invention include all kinds of viruses, regardless of the kind of nucleic acid (RNA, DNA) and the presence or absence of an envelope.
Examples of viruses having an envelope include: influenza viruses with RNA as nucleic acid; coronavirus; SARS coronavirus; SARS coronavirus-2; RS virus; mumps virus; lassa virus; dengue virus; rubella virus; human immunodeficiency virus, human herpesvirus having DNA as nucleic acid; vaccinia virus; hepatitis B virus, and the like.
In addition, as viruses having no envelope, there can be mentioned norovirus having RNA as a nucleic acid; poliovirus; echovirus (ECHO virus); hepatitis A virus; hepatitis E virus; rhinovirus (rhinovirus); astrovirus (Astrovirus); rotavirus (Rotavirus); coxsackievirus (Coxsackievirus); enterovirus (Enterovirus); such as viruses (sapoviruses), adenoviruses (adenoviruses) having DNA as nucleic acid; b19 virus; papilloma virus (papova virus); human papilloma virus, and the like.
Among them, viruses having an envelope are preferable, viruses having an envelope and having RNA as a nucleic acid are more preferable, and influenza virus, human coronavirus, SARS coronavirus-2 are more preferable.
In addition, SARS coronavirus-2 (severe acute respiratory syndrome coronavirus 2,Severe acute respiratory syndrome coronavirus 2,SARS-CoV-2) is a SARS-associated coronavirus responsible for acute respiratory disease (COVID-19).
In the present invention, inactivation of a virus means an action of decreasing or eliminating the activity of the virus and eliminating the infectivity of a host cell.
The virus inactivation can be confirmed, for example, by contacting a test article with a virus, then infecting the virus with a host cell, and measuring the viral infectivity value. Here, the host cell may be a cell which can proliferate a target virus, and for example, a dog kidney cell (MDCK), a Vero kidney epithelial cell (Vero), a duck embryo stem cell-derived cultured cell line (EB 66) may be used in the case of influenza virus, and for example, a human coronavirus, a human ileocecum cancer cell (HCT-8), a VeroE kidney epithelial cell (VeroE 6), and a human liver cancer-derived cultured cell line (Huh 7) may be used in the case of human coronavirus.
Examples of the object to be subjected to contamination with viruses include the skin or mucous membrane of an animal to which viruses are attached, a hard or soft surface of an inanimate object, objects such as waste, and a space in which viruses splash or float. Here, examples of the surface of the inanimate object include: hard surfaces such as counters, sinks, cosmetic rooms, toilets, baths, shower racks, floors, windows, door handles, walls, drain openings, plumbing pipes, etc. in household or commercial facilities; hard surfaces for various appliances, tools, and miscellaneous goods such as kitchen supplies, furniture, telephones, and toys; and soft surfaces of fiber products (carpets, decorative carpets, curtains, cloth furniture, clothing, masks, etc.).
Examples of the waste include general waste (household waste such as food residue, toilet paper, and mask) and industrial waste (sludge, feces, and medical waste). When the waste is contained in the bag, the surface of the bag may be sprayed.
The space may be a space in a general household such as a restaurant kitchen, bedroom, child's house, bathroom, and toilet; in shops, restaurants, hotels, hospitals, workshops, livestock houses, factories, welfare facilities, educational facilities, movie theaters, museums, karaoke cabins, and the like; vehicles such as automobiles (garbage trucks, buses and the like), electric cars and airplanes; and a quasi-closed space (cabinet, storehouse, closet, etc., and storage box (toy, microphone for karaoke, tableware, seasoning, writing tool, stationery)), etc.
Examples of the method of spraying the composition include a method of spraying the composition by filling a known spray container such as a trigger sprayer container (direct pressure or accumulator type) or a dispenser type pump spray container, an aerosol spray container provided with a pressure-resistant container, or the like, with a spray amount being appropriately adjusted. Examples of the method include a method of spraying the virus into a space where the virus exists by filling the virus into a pressurized air atomizing device (electric or manual), an atomizer (nebuliser), an atomizing device such as a diffuser, a diffuser nozzle, or a spraying device such as a sprayer. In the present invention, these containers and devices are also referred to as nebulizers.
In addition, when it is not desired to excessively wet an object which is likely to be contaminated with viruses, the object and a carrier which temporarily receives the composition may be placed in a sealable space, the composition may be temporarily sprayed onto the carrier, and then a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 may be evaporated to fill the container, and the object may be indirectly treated with the glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4.
The time point at which the carrier and the object are placed in the sealable space and the time point at which the composition is sprayed onto the carrier can be arbitrarily set. The carrier is preferably a foam sponge, nonwoven fabric, paper or the like having a large surface area so that a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 is easily evaporated.
In the following, a method of spraying the composition onto a subject who is concerned about contamination with viruses in a garbage truck will be described.
The garbage truck is provided with an inlet for inputting and recycling waste and a packing box for storing the input waste.
When an operator puts waste into a put-in port or performs a pushing-in operation for storing the put-in waste in a packing box, a bag containing the waste may be broken. At this time, if the waste contained in the broken bag is contaminated with viruses, the viruses may spread into the space near the inlet, and there is a concern that the viruses may be exposed to the viruses by the operator of the garbage truck.
From the viewpoint of reducing the possibility of exposing the operator of the garbage truck to viruses, it is preferable to spray the composition to the inlet.
In addition, from the viewpoint of completely spraying the entire surface of the subject suffering from virus contamination, the spraying direction is preferably from the upper portion of the inlet toward the lower portion and/or the side surface of the inlet.
Further, the time point of spraying is preferably spraying in response to driving of the drawing-in device or the insertion device.
In the following, a method of spraying the composition onto a subject who is concerned about virus contamination in a livestock house will be described in particular.
In the animal house, it is preferable that a plurality of sprayers are provided on the ceiling of the animal house and facing downward Fang Penwu. The number of sprayers provided in the animal house is preferably 100m in view of complete and complete spraying 2 More preferably 1 or more, still more preferably 2 or more, still more preferably 3 or more, from the viewpoint of economyIn view of this, it is preferably 30 or less, more preferably 20 or less, and even more preferably 10 or less.
The time point of spraying may be at the time point when virus contamination (e.g., avian influenza confirmation) is found in the house, or may be performed prophylactically.
The average particle diameter of the spray particles is preferably 5 μm or more, more preferably 10 μm or more, further preferably 50 μm or more from the viewpoint of being able to spray the target site and being less susceptible to the air flow, and is preferably 500 μm or less, more preferably 200 μm or less, further preferably 150 μm or less, further preferably 100 μm or less from the viewpoint of suppressing the amount of the composition to be used and completely spraying and from the viewpoint of volatilizing and easily inactivating viruses in the space. The average particle diameter of the spray particles is a volume-based median particle diameter (D50) measured by a laser diffraction type particle analyzer, and can be measured by a method described in examples described later.
In the present invention, from the viewpoint of properly delivering the composition to the surface or space of an object which is concerned about contamination with viruses, in other words, from the viewpoint of preventing the loss caused by evaporation of a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 before delivery, it is preferable to spray the composition in a state where it is not heated (non-heated state). Examples of the spraying method in a non-heated state include the spraying method using a trigger sprayer, atomizer, sprayer, and washer nozzle as described above. The temperature of the composition at the time of spraying is preferably 20 to 40 ℃.
That is, in the present invention, a virus inactivation method that can inactivate viruses in a non-heated state and is safer can be provided. In addition, since spraying is used, the composition can be applied to an object more reliably.
When the composition is sprayed onto the object in a non-heated state, the distance between the spray nozzle for spraying the composition and the object is preferably 3m or less, more preferably 1m or less, from the viewpoint of more efficiently feeding the composition to the object and maximizing virus inactivation. In particular, when the virus is inactivated by spraying a glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 onto a carrier and then evaporating the glycol, the carrier is preferably sprayed within 50cm, more preferably within 30cm, from the viewpoint of preventing the composition from adhering to the surroundings.
After spraying the composition, the composition is preferably left for 30 minutes or longer, from the viewpoint of bringing a diol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 into contact with a virus to exert a sufficient virus inactivating effect.
In the present invention, from the viewpoint of virus inactivation, A1) the concentration of a diol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 in the target space at the time of virus inactivation in the space is preferably 20ppm (volume concentration, the same applies hereinafter) or more, more preferably 50ppm or more, still more preferably 70ppm or more, still more preferably 74ppm or more, still more preferably 80ppm or more, still more preferably 84ppm or more, still more preferably 87ppm or more.
A1 The relationship between the concentration of 1, 2-propanediol in the space and the virus inactivation in a diol having a boiling point of 220℃or less and a carbon number of 2 to 4 can be examined by the following method, wherein the virus inactivation effect is 99% when the concentration in the space is 87ppm and 53% when the concentration in the space is 20 ppm. The concentration (predicted value) at which the desired virus inactivation effect is exhibited may be obtained from a regression equation based on the number measurement result. In addition, the same method can be used for the diols having A1) boiling point of 220 ℃ or lower and a carbon number of 2 to 4 other than 1, 2-propanediol.
1. Method of
Influenza virus type A (A/Puerto Rico/8/1934, H1N 1) strain was used as the test strain. The following operations are performed in advance: at the bottom of a 1L glass bottle manufactured by Tokyo Nitro instruments, 1000. Mu.L of 1, 2-propanediol-impregnated cotton balls were allowed to stand on the bottom surface, and stirred at 500rpm for 30 minutes using a stirrer at about 23 ℃. Or the following operations are performed: a glass bottle having 1. Mu.L of 1, 2-propanediol aqueous solution (0.3 g/mL) dropwise added to the bottom surface was allowed to stand in a 60℃incubator for 30 minutes, and then stirred at about 23℃for 30 minutes using a rotor and a stirrer at 500 rpm. By these operations, the concentration in the space of 1, 2-propanediol is equilibrated.
1.5. Mu.L of influenza virus (8.3X10) 5 FFU) was dried on the cover of the tube for 30 minutes. The cap with the virus attached thereto was rapidly placed in a glass bottle, and 1, 2-propanediol was allowed to react with the virus at room temperature (about 23 ℃) for 30 minutes. At this time, 1, 2-propanediol is not in direct contact with the virus. After the reaction, the virus was recovered in a medium, inoculated into MDCK cells (from dog kidney tubular epithelial cells) previously cultured in a 12-well tray, and cultured at 37 ℃ at 5% co 2 After about 18 hours of incubation under the conditions, the number of foci (focus) formed was determined and the viral infectivity value was determined. The virus inactivating activity of 1, 2-propanediol was calculated from the following formula (5), assuming that the infectivity value at the time of reaction with the control mineral oil was 100%. The test was performed 3 times.
Virus inactivation Effect= -Log [ infectivity value of 1, 2-propanediol/infectivity value of control ] (5)
When measuring the concentration of 1, 2-propanediol in the space, the concentration of 1, 2-propanediol in the space was determined by inserting a gas trap tube having a PTFE tube (manufactured by NICHIAS Co.) into a hole of a cover having a hole of 3.5mm in diameter and allowing the cover to stand for 30 minutes under virus-free conditions. The analysis method and conditions are described in the examples below.
In the present invention, from the viewpoint of virus inactivation, A1) the preferable concentration of the target surface of a diol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 is 0.14mg/cm 2 The concentration is more preferably 0.20mg/cm 2 The above is more preferably 0.25mg/cm 2 The above.
The concentration of the object surface of the diol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 can be measured by capturing the diol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 on the surface by a glass, a plastic dish or the like, then extracting the surface with a solvent such as methanol, ethanol, or acetone, and obtaining the concentration by gas chromatography mass spectrometry (GC/MS).
With respect to the above embodiments, the present invention further discloses the following modes.
< 1 > a virus-inactivating composition for liquid spray comprising A1) 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 and 10 to 60 mass% of water.
< 2 > a method for inactivating viruses, wherein a composition containing A1) 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 and 10 to 60 mass% of water is sprayed onto a hard or soft surface of an inanimate object or waste which is concerned about contamination with viruses.
< 3 > a method for inactivating viruses in a subject space, wherein a composition containing 40 to 90 mass% of a glycol having a boiling point of A1) 220 ℃ or less and a carbon number of 2 to 4 and 10 to 60 mass% of water is sprayed onto a carrier, and the composition is evaporated from the carrier so that the concentration of the glycol having a boiling point of A1) 220 ℃ or less and a carbon number of 2 to 4 in the space becomes 20ppm or more.
The composition or method according to any one of < 4 > and < 1 > to < 3 >, wherein the composition further comprises A2) a glycol ether having a boiling point of 220 ℃ or less and a carbon number of 6.
The composition or method described in < 5 > as < 4 >, wherein A2) in the composition has a boiling point of 220 ℃ or less and a content of glycol ether having 6 carbon atoms of preferably 1 mass% or more, more preferably 3 mass% or more, further preferably 7 mass% or more, and further preferably 40 mass% or less, more preferably 30 mass% or less, further preferably 20 mass% or less, further preferably 15 mass% or less, further more preferably 10 mass% or less.
A composition or method according to < 6 > such as < 4 > or < 5 >, wherein the mass ratio of A2) glycol ether having a boiling point of 220 ℃ or less and a carbon number of 6 to A1) glycol ether having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 to A2) glycol ether having a boiling point of 220 ℃ or less and a carbon number of 6 [ A2)/(A1) +A2) ] is preferably 0.05 or more, more preferably 0.1 or more, still more preferably 0.15 or more, still more preferably 1.0 or less, still more preferably 0.5 or less, and still more preferably 0.3 or less.
A composition or method according to any of < 7 > as defined in any of < 1 > to < 3 >, wherein the composition further comprises A3) an alkyl glyceryl ether.
The composition or method described in < 8 > or < 7 >, wherein the content of A3) alkyl glyceryl ether in the composition is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, further preferably 0.4% by mass or more, and further preferably 2% by mass or less, more preferably 1% by mass or less, further preferably 0.9% by mass or less, further more preferably 0.8% by mass or less.
A composition or method as described in < 9 > such as < 7 > or < 8 >, wherein the mass ratio [ A3)/A1 ] of the C2-4 diol to A1) having a boiling point of 220 ℃ or less, based on A3) in the composition, is preferably 0.001 or more, more preferably 0.005 or more, still more preferably 0.01 or more, still more preferably 0.1 or less, still more preferably 0.05 or less, still more preferably 0.04 or less, still more preferably 0.03 or less.
The composition or method of any of < 10 > as recited in any of < 1 > to < 3 >, wherein the composition further comprises at least 1 fragrance selected from the group consisting of.
Isoamyl formate (boiling point 123 ℃),
butyl acetate (boiling point 126 ℃ C.),
3-methyl-1-butanol (boiling point 132 ℃ C.),
1-pentanol (boiling point 138 ℃ C.),
isoamyl acetate (boiling point 142 ℃ C.),
trans-2-hexenal (boiling point 146 ℃),
cis-3-hexenyl formate (boiling point 155 ℃ C.), and,
Trans-3-hexenol (boiling point 155 ℃ C.), and,
Cis-3-hexenol (boiling point 156 ℃ C.), and,
Hexanol (boiling point 156 ℃ C.),
trans-2-hexenol (boiling point 159 ℃ C.), and,
3, 5-trimethylhexanal (boiling point 167 ℃ C.), and,
2, 4-dimethyl-2-heptanol (boiling point 170 ℃ C.), a process for preparing the same,
3-methyl-3-methoxybutanol (boiling point 174 ℃ C.),
heptanol (boiling point 175 ℃ C.),
benzaldehyde (boiling point 178 ℃),
2, 6-dimethyl-5-heptenal (boiling point 188 ℃ C.), and,
3, 6-dimethyl-3-cyclohexene-1-carbaldehyde (boiling point 189 ℃ C.), and,
3, 5-trimethylhexanol (boiling point 193 ℃ C.), and,
Dihydromyrcenol (boiling point 194 ℃),
linalyl formate (boiling point 202 ℃ C.), and,
Benzyl alcohol (boiling point 205 ℃),
benzyl acetate (boiling point 212 ℃ C.), and,
2-methyl-1-phenylpropan-2-ol (boiling point 215 ℃ C.),
phenethyl alcohol (boiling point 219 ℃),
2-phenylpropionaldehyde (boiling point 220 ℃ C.),
Phenylpropionaldehyde (boiling point 222 ℃ C.),
solanum nigrum aldehyde (boiling point 222 ℃),
phenethyl formate (boiling point 226 ℃ C.), and,
3, 7-dimethyl-4, 6-octadien-3-ol (boiling point 237 ℃ C.), and,
Citronellyl formate (boiling point 235 ℃), and,
Methoxy citronellal (boiling point 238 ℃),
cinnamic alcohol (boiling point 250 ℃), and
cinnamyl formate (boiling point 252 ℃).
The composition or method described in < 11 > or < 10 >, wherein the content of the perfume in the composition is preferably 0.001 mass% or more, more preferably 0.01 mass% or more, and further preferably 1.0 mass% or less, more preferably 0.5 mass% or less.
The composition or method described in < 12 > such as < 10 > or < 11 >, wherein the ratio of the perfume to the glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4 (perfume/glycol having a boiling point of 220 ℃ or less and a carbon number of 2 to 4) in the composition is preferably 0.00001 or more, more preferably 0.0001 or less, still more preferably 0.1 or less, still more preferably 0.01 or less, relative to A1).
The composition or method according to any one of < 13 > and < 1 > to < 3 >, wherein the composition further comprises A2) a glycol ether having a boiling point of 220 ℃ or less and a carbon number of 6, and at least 1 perfume selected from the group consisting of.
Isoamyl formate (boiling point 123 ℃),
butyl acetate (boiling point 126 ℃ C.),
3-methyl-1-butanol (boiling point 132 ℃ C.),
1-pentanol (boiling point 138 ℃ C.),
isoamyl acetate (boiling point 142 ℃ C.),
trans-2-hexenal (boiling point 146 ℃),
cis-3-hexenyl formate (boiling point 155 ℃ C.), and,
Trans-3-hexenol (boiling point 155 ℃ C.), and,
Cis-3-hexenol (boiling point 156 ℃ C.), and,
Hexanol (boiling point 156 ℃ C.),
trans-2-hexenol (boiling point 159 ℃ C.), and,
3, 5-trimethylhexanal (boiling point 167 ℃ C.), and,
2, 4-dimethyl-2-heptanol (boiling point 170 ℃ C.), a process for preparing the same,
3-methyl-3-methoxybutanol (boiling point 174 ℃ C.),
heptanol (boiling point 175 ℃ C.),
benzaldehyde (boiling point 178 ℃),
2, 6-dimethyl-5-heptenal (boiling point 188 ℃ C.), and,
3, 6-dimethyl-3-cyclohexene-1-carbaldehyde (boiling point 189 ℃ C.), and,
3, 5-trimethylhexanol (boiling point 193 ℃ C.), and,
Dihydromyrcenol (boiling point 194 ℃),
linalyl formate (boiling point 202 ℃ C.), and,
Benzyl alcohol (boiling point 205 ℃),
benzyl acetate (boiling point 212 ℃ C.), and,
2-methyl-1-phenylpropan-2-ol (boiling point 215 ℃ C.),
phenethyl alcohol (boiling point 219 ℃),
2-phenylpropionaldehyde (boiling point 220 ℃ C.),
phenylpropionaldehyde (boiling point 222 ℃ C.),
solanum nigrum aldehyde (boiling point 222 ℃),
phenethyl formate (boiling point 226 ℃ C.), and,
3, 7-dimethyl-4, 6-octadien-3-ol (boiling point 237 ℃ C.), and,
Citronellyl formate (boiling point 235 ℃), and,
Methoxy citronellal (boiling point 238 ℃),
cinnamic alcohol (boiling point 250 ℃), and
cinnamyl formate (boiling point 252 ℃).
A composition or method as described in < 14 > and < 13 > wherein the composition further comprises A3) an alkyl glyceryl ether.
The method of any one of < 15 > as defined in < 2 >, < 4 > to < 14 >, wherein the hard or soft surface or waste of the inanimate object which is concerned to be contaminated with the virus is preferably a hard or soft surface or waste of a garbage truck.
The method of < 16 > or < 15 >, wherein the composition is preferably sprayed from the upper part of the inlet of the garbage truck toward the lower part and/or the inside of the side surface of the inlet.
Examples (example)
Examples 1 to 7 and comparative examples 1 to 3 inactivation of influenza virus
The composition was prepared by mixing 1, 2-propanediol (p.g.) with water so AS to reach the concentration shown in table 1, and virus inactivation test was performed in 36L-volume acrylic resin container (trade name, suction box 10L 350×490×240mm manufactured by AS ONE) using the obtained composition. In examples 5, 6 and 7, the perfume compositions shown in a) to c) of table 2 were further mixed. Influenza virus type A (A/Puerto Rico/8/1934, H1N 1) strain was used as the test strain.
Specifically, the composition was sprayed 1 min×3 times (30 seconds at 2 minute intervals) in a container using a compressor type sprayer (manufactured by NE-C803, OMRON, median spray particle diameter: about 5 μm), and at the same time, influenza virus liquid was sprayed (5×10) by the compressor type sprayer 6 FFU/mL) for 3 minutes, and allowed to stand for 3 minutes.
The total amount of the discharged liquid is 0.63g to 0.79g per 36L for 1 min X3 times.
The virus floating in the container space was collected into a total of 3mL of serum-free medium in the bubbler using an aspirator, and collected for 2 minutes. Viruses falling onto a tray previously set on the bottom surface of an acrylic resin container were recovered with 3mL of serum-free medium. After dilution of the recovered virus solution, the virus solution was inoculated into MDCK cells (from dog kidney tubular epithelial cells) previously cultured in a 12-well dish, and cultured at 37℃with 5% CO 2 After about 18 hours of incubation under the conditions, the number of foci formed was determined and the viral infectivity value was determined.
The virus inactivation effect was obtained by the following formula (1). The higher the number, the more excellent the virus inactivation effect, and in this example, less than 30% was regarded as ineffective.
Virus inactivation Effect (%) = [1- (number of infected cells when test article was sprayed/number of infected cells when comparative example 1 (water) was sprayed) ]. Times.100 (1)
In addition, the spray characteristics were judged from the spray weight of the sprayer and from the following formula (2), and less than 90% was judged as defective.
Spray characteristics (%) = (spray weight of test article/spray amount of example 3) ×100 (2)
The surface concentration of 1, 2-propanediol falling onto the surface of the object was determined from the abundance ratio (abundance) of 1, 2-propanediol by adding dropwise 5ml of methanol to the compositions of comparative examples 1 to 3 and examples 1 to 7 falling onto the surface of a plastic culture dish having a diameter of 5cm, and subjecting the extract to GC/MS method.
The results are shown in tables 1 and 2.
TABLE 1
TABLE 2
a) Equivalent preparation (0.02X4) of trans-2-hexenal, n-amyl alcohol, isoamyl alcohol and cis-3-hexeneformate
b) Equal amount of cis-3-hexenol, trans-2-hexenol, isoamyl butyrate, 3-methyl-3-methoxybutanol (0.02X4)
c) Equivalent formulation of trans-2-hexenal, cis-3-hexeneformate, trans-3-hexenol, trans-2-hexenol, 3-methyl-3-methoxybutanol (0.02X15)
As shown in table 1, the compositions of examples 1 to 7 were excellent in spray characteristics, and the compositions showed a virus inactivating effect of 30% or more against either one or both of the floating viruses on the surface of an object or in a space by spraying.
Further, as shown in Table 2, in examples 5, 6 and 7 in which a perfume having a virus inactivating effect was mixed, the virus inactivating effect was improved.
Example 8
The inlet of the garbage truck (medium-sized truck is about 1 m) 3 ) The composition having a 1, 2-propanediol concentration of 80 mass% and a water concentration of 20 mass% was used to test whether an effective concentration was achieved.
Using 2m with door 3 Is made of stainless steel. A total of 40g of the composition was sprayed onto 3 sides and the bottom using a trigger sprayer.
In addition, the median particle diameter (D50) of the composition of example 8 on a volume basis generated by the spray was 89.0 μm as measured according to the following conditions.
< measurement conditions of D50 >
A laser diffraction type particle size distribution measuring apparatus (manufacturer: spraytec, manufactured by Malvern Co., ltd.) was used with a lens of 300mm
Spray direction: spraying in the horizontal direction
Measurement area: the measuring device was disposed so that a place 15cm away from the discharge port of the atomizer in the horizontal direction (spray direction) became a measurement area
Sampling time: 1s
After spraying, the door was closed and left to stand. In the gas analysis, a gas trapping tube (Tenax (registered trademark) TA: manufactured by GERBESEL) was inserted from a hole in the door for 1, 2-propanediol concentration in the space, and the inside air was trapped by sucking for 1 minute at a suction amount of 100 mL/minute.
The captured air was analyzed using a gas chromatography mass spectrometry (GC/MS) device with a thermal desorption system. The GC/MS analysis conditions were set as: the GC column was DB-WAX (manufactured by Agilent), and the temperature raising conditions were set to 40 ℃ (3 minutes) to 6 ℃/minute to 70 ℃ -3 ℃/minute to 240 ℃. The p.g. was determined by injecting a predetermined amount of methanol dilution into a Tenax adsorption tube, and then analyzing the mixture by a GC/MS apparatus equipped with a thermal desorption system in the same manner as described above, and creating a calibration curve based on the detected values.
As a result, after 30 minutes, it was confirmed that the 1, 2-propanediol concentration in the space reached 84ppm.
Example 9
Assuming that there is a possibility of virus infection by a kindergarten child or a school-age child, a composition having a 1, 2-propanediol concentration of 80 mass% and a water concentration of 20 mass% was used to test whether an effective concentration was achieved.
10 sponges were placed on the bottom of a commercially available 68L polypropylene storage box, and the composition was sprayed from 30cm above the sponges 16g (20 times) or 24g (30 times) in total using a trigger sprayer. Further, a wire mesh was laid, and then 20 toys were filled from above, and placed with a cover. The concentration of 1, 2-propanediol in the storage box was measured in the same manner as in example 8.
As a result, after 6 hours, it was confirmed that the 1, 2-propanediol concentration in the storage box reached 50ppm at 20 times of spraying and reached 74ppm at 30 times of spraying.
Examples 10 to 12
The spray characteristics of the sprayer were tested assuming that the garbage inlet in the garbage truck was sprayed. The nebulizer body was changed from a front nozzle unit to an atomizing nozzle unit (manufactured by in-tank corporation, hollow cone nozzle KB 80125N: foreign matter passing diameter 0.3 mm) using Mister Auto 2.5L (maximum pressure about 0.3 MPa) manufactured by Kagaku Co., ltd. As spray solutions, the formulation solutions of examples 10 to 12 shown in table 3 were prepared.
As a result, the conical spray was successful without any problem.
TABLE 3
Examples 13 and 14
The effect of improving the spray characteristics of the component A2) was tested. The nebulizer body was a Mister Auto 2.5L (maximum pressure of about 0.3 MPa) manufactured by Kagaku Co., ltd.) and the front nozzle portion was an atomizing nozzle (hollow cone nozzle KB 8010N: foreign matter passing diameter 0.25mm manufactured by Pond Co., ltd.). In the spray liquid, a mixed liquid having a 1, 2-propanediol concentration of 60 mass% and a water concentration of 40 mass% was prepared in example 13, and a mixed liquid having a 1, 2-propanediol concentration of 60 mass%, a diethylene glycol monoethyl ether concentration of 10 mass% and a water concentration of 30 mass% was prepared in example 14. The diameter of a circle of the wet portion formed on the bottom surface was measured by spraying a metal holder vertically downward for 10 seconds while fixing the nozzle portion so that the height thereof became 30 cm.
As a result, example 14 exhibited a finer and stable spray pattern, and as for the diameter, example 13 was 20cm, and example 14 was 23cm. It was shown that by adding component A2), the cone-like spray pattern can be improved.
The median particle diameter (D50) of the formulation of example 13 was 75.0 μm based on the volume of the formulation at the time of spraying, as measured under the following conditions.
< measurement conditions of D50 >
A laser diffraction type particle size distribution measuring apparatus (manufacturer: spraytec, manufactured by Malvern Co., ltd.) was used with a lens of 300mm
Spray direction: spraying in the horizontal direction
Measurement area: the measuring device was disposed so that a place 15cm away from the discharge port of the atomizer in the horizontal direction (spray direction) became a measurement area
Sampling time: 1s
For comparison, instead of the above spraying, the formulation of example 13 was sprayed using the compressor sprayer (NE-C803, manufactured by OMRON Co.) used in example 1. Specifically, a metal bracket was used in the same manner as described above, and the nozzle portion was fixed so as to have a height of 30 cm. In the state of the product, the ejection direction was the horizontal direction, so that the hose bent into a crank shape was connected so as to be able to spray vertically downward, and the spraying was performed vertically downward for 10 seconds.
As a result, the spray particles spread in a range of about 20cm from the discharge port, and it was not confirmed that a stable spray pattern was present on the drop surface. The median particle diameter (D50) measured in terms of volume basis at the time of spraying according to the above conditions was 4 μm.
Example 15 and example 16 (Virus inactivation test by spraying)
1. Method of
The virus inactivation test was performed in a 36L volume acrylic resin container (trade name, suction box 10L 350X 490X 240mm manufactured by AS ONE). Influenza virus type A (A/Puerto Rico/8/1934, H1N 1) strain was used as the test strain. Influenza virus liquid (1.8X10) 8 FFU/mL) is sprayed by a compressor sprayer (NE-C803, manufactured by omron). The compositions were prepared by mixing 1, 2-propanediol (p.g., manufactured by fuji film and photoplethysm corporation) and 2-ethylhexyl glycerol ether (GE-EH, manufactured by fuji film and photoplethysm corporation) with water so as to reach the concentrations (mass%) shown in table 4, and spraying the mixture into the acrylic resin container from the hole in the central portion of the cap via a sprayer. The nebulizer body used Mister Auto2.5L (maximum pressure about 0.3 MPa) manufactured by Kagaku Co., ltd.) and the tip nozzle portion was changed to a nozzle for fine mist (manufactured by in-tank Co., ltd., hollow cone nozzle KB 8010N: foreign matter passing diameter 0.25 mm).
Specifically, the acrylic tank was alternately sprayed with the composition for 5 seconds, the virus for 10 seconds, and the composition for 5 seconds, and then allowed to stand. 15 minutes after the start of the test, 4 sheets of the serum-free medium (manufactured by Thermo Fisher Scientific) which had fallen to the bottom surface of the acrylic resin container were collected by each tray with 1.2mL of the serum-free mediumViruses on plates (manufactured by AGC TECHNO GLASS Co.) 3cm in diameter. After dilution of the recovered virus solution, MDCK cells (derived from dog kidney tubular epithelial cells) previously cultured in a 12-well plate were infected, and the virulence value was determined by a lesion formation test (Focus Forming Assay). Specifically, at 37℃5% CO 2 After about 18 hours of incubation under the conditions, the number of foci formed was determined and the viral infectivity value was determined.
The virus inactivating effect of the composition was determined by the following formula (7) using the value of the infectivity at the time of reaction with water as a control.
Virus inactivation Effect (Log reduction) = -Log 10 [ infectivity value at composition spraying/infectivity value of control ]](7)
The viscosity of the compositions of example 15 and example 16 shown in table 4 was measured under the following conditions.
< measurement conditions of viscosity >)
Ultrasonic viscometer apparatus (manufactured by Maruyasu industries, inc., VISCOTECH)
Measurement temperature of 20 DEG C
The amount of the filler in the sensor portion was about 0.2g
After spraying, the median particle diameter (D50) of each composition shown in table 4 was measured based on the volume of the sprayed liquid obtained by spraying.
< measurement conditions of D50 >
A laser diffraction type particle size distribution measuring apparatus (manufacturer: spraytec, manufactured by Malvern Co., ltd.) was used with a lens of 300mm
Spray direction: spraying in the horizontal direction
Measurement area: the measuring device was disposed so that a place 15cm away from the discharge port of the atomizer in the horizontal direction (spray direction) became a measurement area
Sampling time: 1s
The results are shown in table 4. The results represent the average of 4 plates. The higher the number, the more excellent the virus inactivating effect. The detection limit of the test was 99.97% (3.56 Log reduction), and the activity value of the sample (P.G.40 mass% + GE-EH 0.7 mass%) below the detection limit, which was the detection amount of the viral load value, was > 99.97 (> 3.56).
TABLE 4
Formulation examples 1 and 2 for liquid spray virus inactivation composition and inactivation of influenza virus in liquid phase of reference example 1
1. Method of
Influenza virus type A (A/Puerto Rico/8/1934, H1N 1) strain was used as the test strain. Sample solutions were prepared in such a manner that the final concentrations (v/v%) became as shown in Table 4 below. Influenza virus solution (6.0X10) in Hybridoma-SFM medium (Thermo Fisher Scientific) as solvent 5 FFU) 5 μl was reacted with 45 μl of the sample solution at room temperature (about 23 ℃) for 5 minutes. After the reaction, the virus was diluted with medium, inoculated into MDCK cells (from dog kidney tubular epithelial cells) previously cultured in a 12-well tray, and cultured at 37℃with 5% CO 2 After about 18 hours of incubation under the conditions, the number of foci formed was determined and the effect of virus inactivation was determined. The virus inactivating effect of each sample solution was calculated according to the following formula (6) using the infectivity value at the time of reaction with water as a control. The test was performed the following number of times.
Virus inactivation Effect= -Log [ infectivity value of sample solution/infectivity value of control ] (6)
2. Results
The results are shown in Table 5. After multiple trials, the average is represented by two significant digits.
As shown in Table 5, it was confirmed that 2-ethylhexyl glycerol ether had an effect of inactivating viruses, and that the composition of formulation example 2 in which 2-ethylhexyl glycerol ether was mixed had an improved effect of inactivating viruses.
As a result, it was found that a composition containing A1) 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 and 10 to 60 mass% of water, and A3) an alkyl glyceryl ether is useful as a virus-inactivating composition for liquid spraying.
TABLE 5
| Blending components | Formulation example 1 | Formulation example 2 | Reference example 1 |
| 1, 2-propanediol | 63 | 40 | 0 |
| 2-ethylhexyl glyceryl ether | 0 | 1 | 1 |
| Cis-3-hexenyl formate | 0.01 | 0.09 | 0 |
| Hexyl acetate | 0.09 | 0.01 | 0 |
| Water and its preparation method | 36.9 | 58.9 | 99.0 |
| Totalizing | 100.0 | 100.0 | 100.0 |
| Virus inactivation Effect (Log reduction value) | 3.2 | 5.7 or more | 2.3 |
| (number of tests) | 3 | 2 | 1 |
* Penetol GE-EH flower Wang Zhizao
* Measuring above a limit value
Reference example 2 fragrance indicator test
1. Method of
Compositions a to M prepared by mixing 1, 2-propanediol (p.g.) with water and a perfume to the concentrations shown in table 6 were filled into trigger containers, and fragrance indicators were tested. Specifically, a 40L garbage bag was filled with waste paper and left to stand outdoors (air temperature about 15 ℃). The composition was sprayed 10 times or 20 times from above obliquely onto the surface of each garbage bag, and the fragrance intensity immediately after spraying, after 30 minutes and after 60 minutes was evaluated from a distance of 30cm according to the following 6-stage odor intensity expression method. A composition having a fragrance intensity of 2.5 or more immediately after spraying and a fragrance intensity of 1 or less after 30 minutes or 60 minutes was judged to be suitable as an indicator. Compositions having fragrance intensity greater than 1 were judged unsuitable.
(6-stage odor intensity representation)
0: odorless, 1: barely perceptible odor, 2: weak smell, 3: smell, 4: stronger odor, 5: intense smell
2. Results
The results are shown in table 6.
Reference example 3 inactivation of influenza Virus of perfume
1. Method of
Influenza virus type A (A/Puerto Rico/8/1934, H1N 1) strain was used as the test strain. The fragrance shown in Table 7 was impregnated into a cotton ball in an amount of 75. Mu.L, and the cotton ball was sealed by adhering a double-sided tape to a cap portion of a 15mL glass bottle (Maruemu Corporation), so that the fragrance of the fragrance was filled for 30 minutes. Influenza virus was allowed to 1.5. Mu.L (8.3X10) 5 FFU) was dried on the cover of the frozen vial (Thermo Fisher Scientific) for 30 minutes. The cap of the vial with the virus attached was placed in a glass vial and the fragrance compound was allowed to react with the virus for 30 minutes at room temperature (about 23 ℃). At this time, the perfume compound is placed in the cap portion of the bottle, and the virus is placed in the bottom portion of the bottle, maintaining a state in which the perfume compound is not in direct contact with the virus. After the reaction, viruses were recovered using a hybrid-SFM medium (Thermo Fisher Scientific) and inoculated into MDCK cells (from dog kidney tubular epithelial cells) previously cultured in a 12-well tray at 37℃with 5% CO 2 After about 18 hours of incubation under the conditions, the number of foci formed was determined and the viral infectivity value was determined. The virus inactivating activity of each perfume was calculated from the following formula (3) using the infectivity value at the time of reaction with mineral oil as a control. The test was performed 3 times.
Virus inactivation Effect= -Log [ infectivity value of perfume/infectivity value of control ] (3)
2. Results
The results are shown in table 7. The average of 3 times is represented by a significant digit.
TABLE 7
| Test examples | Boiling point (. Degree. C.) | Virus inactivation Effect (log reduction value) | |
| 1 | Isopentyl formate | 123 | About 1 |
| 2 | Butyl acetate | 126 | About 4 |
| 3 | 3-methyl-1-butanol | 132 | About 7 |
| 4 | 1-pentanol | 138 | About 7 |
| 5 | Isoamyl acetate | 142 | About 2 |
| 6 | Trans-2-hexenal | 146 | About 7 |
| 7 | Cis-3-hexenyl formate | 155 | About 7 |
| 8 | Trans-3-hexenol | 155 | About 7 |
| 9 | Cis-3-hexenol | 156 | About 7 |
| 10 | Hexanol | 156 | About 4 |
| 11 | Trans-2-hexenol | 159 | About 7 |
| 12 | Trimethyl hexanal | 167 | About 4 |
| 13 | Dimetol | 170 | About 4 |
| 14 | 3-methyl-3-methoxybutanol | 174 | About 7 |
| 15 | Heptanol (heptanol) | 175 | About 4 |
| 16 | Benzaldehyde | 178 | About 7 |
| 17 | MELONAL | 188 | About 4 |
| 18 | Cyclovertal | 189 | About 4 |
| 19 | Trimethyl hexanol | 193 | About 4 |
| 20 | Dihydromyrcenol | 194 | About 4 |
| 21 | Linalyl formate | 202 | About 7 |
| 22 | Benzyl alcohol | 205 | About 7 |
| 23 | Benzyl acetate | 212 | About 6 |
| 24 | Dimethylbenzyl alcohol | 215 | About 4 |
| 25 | Phenethyl alcohol | 219 | About 7 |
| 26 | Solanum nigrum alcohol | 220 | About 4 |
| 27 | Phenyl propanal | 222 | About 4 |
| 28 | Solanum nigrum aldehyde | 222 | About 4 |
| 29 | Benzoic acid phenethyl ester | 226 | About 7 |
| 30 | Ocimum basilicum enol (Mugol) | 237 | About 4 |
| 31 | Citronellyl formate | 235 | About 4 |
| 32 | Methoxy citronellal | 238 | About 4 |
| 33 | Cinnamic alcohol | 250 | About 4 |
| 34 | Cinnamyl formate | 252 | About 7 |
Reference example 4 inactivation of coronaviruses of the inventive product
1. Method of
SARS-CoV-2JPN/Kanagawa/KUH003 was used as the test strain. To 27. Mu.L of the solution having the composition shown in Table 7, 3. Mu.L of the virus suspension was added and mixed. Reacting for 5 min at room temperature After 5 minutes, the cells were diluted 10-fold with a cell maintenance medium (a medium obtained by adding 2% fetal bovine serum, 100U/mL penicillin, 100. Mu.g/mL streptomycin, and 418 1mg/mL geneticin to Dalberg modified eagle Medium (NACALAAI TESQUE, INC.)) and the cells were diluted 3-fold in stages. In advance with 96 hole tray culture of VeroE6/TMPRSS2 cells, each hole inoculated with diluted reaction solution 100u L, 37 degrees C, 5%CO 2 Infection is carried out for about 1 hour under the condition. After infection, the dilutions were removed entirely, washed 2 times with cell maintenance medium, and incubated with fresh cell maintenance medium for 3 days. After the culture, the presence or absence of morphological changes of cells (cell modifying effect: CPE) was observed by using an inverted phase contrast microscope, and the 50% tissue culture infection amount (TCID) was calculated by the Behrens-Karber method 50 ) The viral infection value was converted into a viral infection value per 1mL of the reaction solution. The virus inactivating activity of each solution was calculated according to the following formula (4) using the infectivity value at the time of reaction with water as a control. The test was performed 3 times.
Virus inactivation Effect = control logTCID 50 LogTCID of the reaction solution/mL 50 Infectivity value of/mL control](4)
2. Results
The results are shown in table 8.
TABLE 8
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Claims (12)
1. A method for inactivating viruses, wherein,
the virus inactivation method is to spray a composition containing A1) 40 to 90 mass% of glycol with a boiling point of 220 ℃ or lower and a carbon number of 2 to 4 and 10 to 60 mass% of water onto the surface of an object which is worry to be polluted by the virus.
2. The method for inactivating viruses according to claim 1, wherein,
the spraying mode is a non-heating mode.
3. A method for inactivating viruses according to claim 1 or 2, wherein,
the virus inactivation method is to spray by using any sprayer selected from a pressurized air atomizing spraying device, an atomizing device and a diffusion device.
4. A method for inactivating viruses according to claim 3, wherein,
the average particle diameter of the spray particles is 5-500 μm at a point 15cm from the spray outlet of the sprayer in the spray direction.
5. The method for inactivating viruses according to any one of claim 1-4, wherein,
the composition is sprayed in an amount of 0.1g to 500 g/min.
6. The method for inactivating viruses according to any one of claim 2 to 5, wherein,
when the composition is sprayed onto an object in a non-heated state, the distance between the spray opening from which the composition is sprayed and the object is within 3 m.
7. The method for inactivating viruses according to any one of claim 1 to 6, wherein,
The virus is an RNA virus having an envelope.
8. A method for inactivating viruses in a subject space, wherein,
the virus inactivation method is to spray a composition containing 40-90 mass% of glycol with a boiling point of A1) below 220 ℃ and a carbon number of 2-4 and 10-60 mass% of water onto a carrier, and evaporate the composition from the carrier so that the concentration of the glycol with a boiling point of A1) below 220 ℃ and a carbon number of 2-4 in a space reaches more than 20 ppm.
9. A composition comprising, in a major proportion,
the composition is a liquid spray virus-inactivating composition,
contains A1) 40 to 90 mass% of a glycol having a boiling point of 220 ℃ or lower and a carbon number of 2 to 4, and 10 to 60 mass% of water.
10. The composition of claim 9, wherein,
further comprising A3) an alkyl glyceryl ether.
11. The composition according to claim 9 or 10, wherein,
further contains a perfume having a boiling point of 120 ℃ to 260 ℃.
12. The composition according to any one of claim 9 to 11, wherein,
the viscosity of the composition at 20 ℃ is 2-40 mPas.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021-069361 | 2021-04-15 | ||
| JP2021-173096 | 2021-10-22 | ||
| JP2022-018951 | 2022-02-09 | ||
| JP2022018951 | 2022-02-09 | ||
| PCT/JP2022/017875 WO2022220290A1 (en) | 2021-04-15 | 2022-04-14 | Virus inactivation composition for liquid atomization |
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| Publication Number | Publication Date |
|---|---|
| CN117119884A true CN117119884A (en) | 2023-11-24 |
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ID=88804279
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280028430.7A Pending CN117119884A (en) | 2021-04-15 | 2022-04-14 | Virus inactivating composition for liquid spray |
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| Country | Link |
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| CN (1) | CN117119884A (en) |
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2022
- 2022-04-14 CN CN202280028430.7A patent/CN117119884A/en active Pending
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