CN117089438A - Full-automatic nucleic acid molecule hybridization instrument - Google Patents
Full-automatic nucleic acid molecule hybridization instrument Download PDFInfo
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- CN117089438A CN117089438A CN202310881120.6A CN202310881120A CN117089438A CN 117089438 A CN117089438 A CN 117089438A CN 202310881120 A CN202310881120 A CN 202310881120A CN 117089438 A CN117089438 A CN 117089438A
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- acid molecule
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- 238000009396 hybridization Methods 0.000 title claims abstract description 26
- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 19
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 19
- 102000039446 nucleic acids Human genes 0.000 title claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 178
- 239000002699 waste material Substances 0.000 claims abstract description 58
- 230000007246 mechanism Effects 0.000 claims abstract description 23
- 239000011159 matrix material Substances 0.000 claims abstract description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 238000005485 electric heating Methods 0.000 claims description 9
- 239000000741 silica gel Substances 0.000 claims description 9
- 229910002027 silica gel Inorganic materials 0.000 claims description 9
- 239000011229 interlayer Substances 0.000 claims description 6
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000004891 communication Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to a full-automatic nucleic acid molecule hybridization instrument which comprises a shell, a reaction box, a cover plate, a waste liquid tank, a waste liquid box, a liquid pipeline and a plurality of liquid bottles, wherein a first support and a second support are arranged in the reaction box from top to bottom, the reaction box is arranged at the upper end of the first support, a plurality of reaction tanks with upper openings are distributed in the reaction box in a matrix mode, a liquid outlet is arranged on the bottom wall of the reaction tank, a first notch is arranged on one side of the shell, the waste liquid tank is assembled at the upper end of the second support through a first lifting mechanism, a blocking block is arranged in the waste liquid tank, a liquid leakage port is arranged on the bottom wall of the waste liquid tank, the waste liquid box is arranged below the liquid leakage port, a second notch is arranged on one side of the shell, a second lifting mechanism is arranged on the top wall in the shell, the cover plate is horizontally arranged above the reaction box and connected with the second lifting mechanism, a liquid inlet pipe corresponding to the waste liquid tank one by one, the liquid pipeline is arranged at the upper end of the cover plate and connected with the liquid inlet pipe, and the liquid pipeline inlet is connected with a liquid pump in each liquid bottle. The advantages are that: the space layout is more compact and the use is more convenient.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a full-automatic nucleic acid molecule hybridization instrument.
Background
The molecular hybridization instrument is a device for detecting whether the genome to be detected contains a known gene sequence by adopting a nucleic acid molecular hybridization technology, and is also in-vitro diagnosis equipment. It is generally necessary to add one or more reagents to a plurality of reaction tanks, react with or without heating, and remove the waste liquid from the reaction tanks after the measurement to be tested is completed.
Most of the existing molecular hybridization apparatuses are provided with a mechanical motion platform inside to realize mobile liquid injection of a liquid injection system, so that the requirements on control precision are high, meanwhile, the requirements on internal space are also high, and meanwhile, the manufacturing cost is also high.
Disclosure of Invention
The invention aims to provide a full-automatic nucleic acid molecule hybridization instrument, which effectively overcomes the defects of the prior art.
The technical scheme for solving the technical problems is as follows:
the utility model provides a full-automatic nucleic acid molecule hybridization appearance, which comprises a housing, the reaction box, the apron, the waste liquid groove, the waste liquid box, liquid pipeline and a plurality of liquid bottle, top-down is equipped with fretwork and the first support and the second support that the level set up in the aforesaid reaction box, above-mentioned reaction box is shelved in the aforesaid first support upper end, be the matrix distribution in the aforesaid reaction box and have a plurality of upper portion open reaction tank, the aforesaid reaction tank diapire is equipped with the liquid outlet that runs through from top to bottom, above-mentioned casing one side is equipped with the first breach that the aforesaid reaction box horizontal push in or took out, above-mentioned waste liquid groove passes through first elevating system and assembles in the upper end of above-mentioned second support, be equipped with the shutoff piece with above-mentioned liquid outlet one-to-one in the aforesaid waste liquid groove, above-mentioned waste liquid groove diapire is equipped with the weeping mouth, above-mentioned waste liquid box sets up in the diapire in the aforesaid casing on the diapire, and be located the below of weeping mouth, be equipped with the second breach that the aforesaid waste liquid groove horizontal push in or take out in the aforesaid casing on the roof, the upper portion, the aforesaid apron horizontal setting up in the aforesaid reaction box top, and the aforesaid is equipped with the aforesaid liquid inlet tube is connected with the aforesaid liquid inlet tube through the aforesaid liquid inlet, the upper end is connected to the liquid inlet tube one-to-feed liquor, the liquid pipeline is equipped with one-through to the aforesaid liquid in-feed liquor.
On the basis of the technical scheme, the invention can be improved as follows.
Further, the intelligent control system further comprises a controller, wherein the controller is arranged in the shell, a touch screen connected with the controller is arranged on the outer surface of the shell, and the electric control valves are respectively connected with the controller.
Further, the first lifting mechanism comprises a plurality of first electric pushing rods, a controller with a screen is arranged in the shell, and the first electric pushing rods are connected with the controller.
Further, the second lifting mechanism comprises a plurality of second electric pushing rods, and the second electric pushing rods are connected with the controller.
Further, the liquid distributor comprises a flow channel, a liquid outlet communicated with the flow channel and a plurality of liquid inlets communicated with the flow channel are formed in the surface of the flow channel, the liquid outlet is connected and communicated with the liquid inlet pipe, the liquid inlets are respectively connected with a liquid pump matched with each liquid bottle through hoses, and a second electric control valve is respectively arranged at the liquid inlets and is connected with the controller.
Further, an interlayer cavity is arranged in the reaction box, an electric heating device is arranged in the interlayer cavity, and the electric heating device is connected with the controller.
Further, a plurality of ultraviolet light sources are embedded at the lower end of the cover plate, and the ultraviolet light sources are respectively connected with the controller.
Further, the bottom wall of the waste liquid tank is a conical surface, and the tip of the conical surface is located at the liquid leakage port.
Further, the plugging block comprises a vertical connecting column and a silica gel plug, wherein the connecting column is fixed on the inner bottom wall of the waste liquid tank, and the silica gel plug is wrapped and arranged outside the connecting column.
The beneficial effects of the invention are as follows: structural design is reasonable, and spatial layout is compacter, and it is more convenient to use, annotates the liquid that liquid process realized one to one through the feed liquor pipe, need not to annotate the liquid unit and remove, annotates liquid precision requirement and reduces by a wide margin, has effectively reduced manufacturing cost.
Drawings
FIG. 1 is a schematic diagram of the structure of a fully automatic nucleic acid molecule hybridization apparatus according to the present invention;
FIG. 2 is a sectional view showing the structure of a fully automatic nucleic acid molecule hybridization apparatus according to the present invention.
In the drawings, the list of components represented by the various numbers is as follows:
1. a housing; 2. a reaction cassette; 3. a cover plate; 4. a waste liquid tank; 5. a waste liquid box; 6. a liquid agent pipeline; 7. a first lifting mechanism; 8. a second lifting mechanism; 9. a shunt; 21. a first bracket; 22. a second bracket; 23. a reaction tank; 24. an electric heating device; 31. a liquid inlet pipe; 41. a block; 411. a connecting column; 412. and a silica gel plug.
Detailed Description
The principles and features of the present invention are described below with reference to the drawings, the examples are illustrated for the purpose of illustrating the invention and are not to be construed as limiting the scope of the invention.
Examples: as shown in fig. 1 and 2, the full-automatic nucleic acid molecule hybridization apparatus of this embodiment includes a casing 1, a reaction cassette 2, a cover plate 3, a waste liquid tank 4, a waste liquid tank 5, a liquid pipeline 6, and a plurality of liquid bottles (not shown in the drawings), wherein a first support 21 and a second support 22 are provided in the reaction cassette 2, which are hollowed out and horizontally disposed, from top to bottom, the reaction cassette 2 is placed on the upper end of the first support 21, a plurality of reaction tanks 23 with upper openings are distributed in a matrix in the reaction cassette 2, a liquid drain opening penetrating up and down is provided in the bottom wall of the reaction tank 23, a first notch for horizontally pushing in or pulling out the reaction cassette 2 is provided on one side of the casing 1, the waste liquid tank 4 is mounted on the upper end of the second support 22 by a first lifting mechanism 7, a plugging block 41 corresponding to the liquid drain opening is provided in the waste liquid tank 4, the bottom wall of the waste liquid tank 4 is provided on the bottom wall of the casing 1, a plurality of reaction tanks 23 are disposed below the liquid drain opening, a second notch for horizontally pushing out or pulling out the waste liquid tank 4 is provided on one side of the casing 1, a second lifting mechanism is provided on the side of the casing 3, a second liquid inlet 31 is connected to the liquid tank 3 and is connected to the upper end of the liquid tank 3 by a second lifting mechanism, and the liquid inlet 31 is connected to the liquid tank 3 and the liquid tank 3 is connected to the upper end of the liquid tank 3 by a second lifting mechanism, and the liquid tank 3 is connected to the liquid inlet 3 by a liquid inlet and the liquid pipe 3 is connected to the liquid tank 3 by a liquid inlet.
The use process is as follows:
firstly, the reaction box 2 is pulled out (not separated) from a first notch on one side of the machine shell 1, then the hybridization membrane strip is put into a reaction groove 23 in the reaction box 2, then the reaction box 2 is pushed into the first notch, so that the reaction groove 23 is positioned above a corresponding blocking block 41, next, a second lifting mechanism 8 is operated to drive a cover plate 3 to move downwards and abut against the upper end of the reaction box 2, so that the cover plate 3 covers each reaction groove 23, simultaneously, a first lifting mechanism 7 is operated to drive a waste liquid groove 4 to move upwards, so that each blocking block 41 in the waste liquid groove 4 moves upwards to the upper end to block a liquid outlet of the bottom wall of the corresponding reaction groove 23, so that after preparation is finished, a liquid pump in one liquid agent bottle is started, the liquid agent is pumped through the liquid pump and is conveyed into each liquid inlet pipe 31 through the liquid agent pipeline 6, and the liquid agent (reagent) is injected into the corresponding reaction tank 23 through the liquid inlet pipe 31, so that the liquid agent (reagent) contacts with the hybridization membrane strip to perform the test process, the liquid agent is heated to meet the temperature in the test process, after the test is finished, the first lifting mechanism 7 is operated to drive the waste liquid tank 4 to move downwards, the blocking block 41 is separated from the liquid outlet, waste liquid in the reaction tank 23 can be discharged through the liquid outlet and falls into the waste liquid tank 4, then is converged to the liquid outlet along the bottom wall of the waste liquid tank 4, then falls into the waste liquid box 5 from the liquid outlet, after a period of time, the second lifting mechanism 8 is operated to drive the cover plate 3 to move upwards to return, then the reaction box 2 is pulled out from the first notch on one side of the machine shell 1, the hybridization membrane strip in the reaction tank 23 is taken out, the reaction box 2 is pushed into the machine shell, meanwhile, the second lifting mechanism 8 is operated to drive the cover plate 3 to move downwards, then, the liquid pump in the liquid bottle filled with the cleaning liquid is started, the cleaning liquid is injected into the liquid inlet pipe 31, the reaction tank 23 is flushed, the flushed waste liquid flows into the waste liquid tank 4 below from the liquid outlet of the bottom wall of the reaction tank 23, then flows into the waste liquid box 5 below through the liquid outlet of the waste liquid tank 4, and then the waste liquid box 5 is pulled out from the second notch on one side of the machine shell 1 to clean the waste liquid, so that the whole process is finished. In the whole device, the mechanical motion platform is not required inside the reaction tank 23, only two lifting mechanisms are required to realize, the internal space layout is more compact, one-to-one filling and cleaning in the reaction tank 1 are realized, movable filling is not required, the experimental period is shorter, and the production cost of the instrument is also reduced.
What needs to be stated is: the reaction box 2 and the waste liquid box 5 and the corresponding first notch and second notch all adopt the structural design that the existing key in the market pops up at present, the specific structure can refer to the structural design that the key of the water tank (box) of the existing steaming and baking box pops up in the market, after the reaction box 2 and the waste liquid box 5 are pushed into the corresponding first notch and second notch, the reaction box 2 and the waste liquid box 5 are automatically locked, after the key is pressed down, the reaction box 2 and the waste liquid box are automatically popped up at a slow speed, and the specific structure is not repeated here.
In this embodiment, the first bracket 21 and the second bracket 22 are hollow flat plate brackets with upper and lower through areas in the middle. Or may be designed as a drawer-shaped holder that mates with the reaction cassette 2 and the waste liquid cassette 5.
In this embodiment, a first electrically controlled valve is disposed at the lower end of each liquid inlet pipe 31, and the purpose of this is: when the hybridization membrane strips are not added into all the reaction tanks 23 in one test, the first electric control valve of the liquid inlet pipe 31 corresponding to the reaction tank 23 for adding the hybridization membrane strips can be opened in a targeted manner when the liquid is added later, so that accurate liquid adding is realized.
As a preferred embodiment, the device further comprises a controller, the controller is disposed in the housing 1, a touch screen (denoted by a in the figure) connected to the controller is disposed on the outer surface of the housing 1, and the first electrically controlled valves are respectively connected to the controller and are connected to a power supply through the controller.
In the above embodiment, the apparatus is provided with a controller (PLC or conventional industrial personal computer) and is connected with related electronic components (such as a first electronic control valve), and intelligent and automatic operation is realized through conventional setting of parameters and programs.
As a preferred embodiment, the first lifting mechanism 7 includes a plurality of first electric pushers, a controller with a screen is provided in the casing 1, and the first electric pushers are connected to the controller and are connected to a power supply through the controller.
In the above embodiment, the controller controls the plurality of first electric pushrods to start, thereby driving the waste liquid tank 4 to rise and fall, and realizing automatic operation.
Similarly, the second lifting mechanism 8 includes a plurality of second electric pushing rods, and the second electric pushing rods are connected to the controller and connected to a power supply through the controller.
As a preferred embodiment, the liquid dispenser further comprises a flow divider 9, a flow passage is provided inside the flow divider 9, a liquid outlet communicated with the flow passage and a plurality of liquid inlets communicated with the flow passage are provided on the surface of the flow divider 9, the liquid outlet is connected and communicated with the liquid inlet pipe 31, the liquid inlets are respectively connected with a liquid pump adapted in each liquid bottle through hoses, and second electric control valves (not shown) are respectively provided at the liquid inlets and are connected with the controller.
In the above embodiment, the flow divider 9 is designed so that the liquid agent can be smoothly dispensed to the liquid inlet pipe 31 via the liquid pump, thereby smoothly entering the corresponding reaction tank 23.
In this embodiment, an interlayer cavity is provided in the reaction cassette 2, and an electric heating device 24 is provided in the interlayer cavity, and the electric heating device 24 is connected to the controller. The electric heating means 24 employs an electric heating plate, preferably disposed around the bottom wall of each reaction tank 23, for heating each reaction tank 23.
As a preferred embodiment, a plurality of ultraviolet light sources are embedded in the lower end of the cover plate 3, and the ultraviolet light sources are respectively connected with the controller.
In the above embodiment, the ultraviolet light source is designed to sterilize the reaction tank 23 after the test (cleaning) is completed, so that the subsequent test can be performed without cross contamination.
In a preferred embodiment, the bottom wall of the waste liquid tank 4 is tapered, and a tapered tip is located at the liquid leakage port.
In the above embodiment, the conical surface design of the bottom wall of the waste liquid tank 4 is beneficial to the downward flow of the liquid in the waste liquid tank, so that the liquid is discharged more thoroughly.
As a preferred embodiment, the plugging block 41 includes a vertical connection column 411 and a silica gel plug 412, the connection column 411 is fixed on the inner bottom wall of the waste liquid tank 4, and the silica gel plug 412 is wrapped and disposed outside the connection column 411.
In the above embodiment, the plugging block 41 has a reasonable structural design, is relatively stable to install, and is supported by the connecting column 411 inside the silica gel plug 412, so that the deformation of the silica gel plug in the horizontal direction is avoided.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present invention.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present invention, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present invention, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
While embodiments of the present invention have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the invention, and that variations, modifications, alternatives and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the invention.
Claims (9)
1. A full-automatic nucleic acid molecule hybridization instrument, characterized in that: the device comprises a shell (1), a reaction box (2), a cover plate (3), a waste liquid tank (4), a waste liquid box (5), a liquid pipeline (6) and a plurality of liquid bottles, wherein a first bracket (21) and a second bracket (22) which are hollowed out and horizontally arranged are arranged in the reaction box (2) from top to bottom, the reaction box (2) is placed at the upper end of the first bracket (21), a plurality of reaction grooves (23) with upper openings are distributed in the reaction box (2) in a matrix manner, a liquid draining port penetrating through the bottom wall of the reaction groove (23) up and down is arranged on one side of the shell (1), a first notch for horizontally pushing or pulling the reaction box (2) is arranged on one side of the shell (1), the waste liquid tank (4) is assembled at the upper end of the second bracket (22) through a first lifting mechanism (7), a liquid draining port is arranged in the waste liquid tank (4), a liquid draining port is arranged on the bottom wall of the reaction box (2), the bottom wall of the reaction box (5) is arranged on the shell (1) and is provided with a second notch for horizontally pushing or pulling the waste liquid tank (4) up and down, the waste liquid tank (4) is arranged on one side of the shell (8) and is connected with the second lifting mechanism (8), the waste liquid tank is characterized in that liquid inlet pipes (31) corresponding to the waste liquid tanks (4) one by one are arranged on the cover plate (3) in a penetrating mode, liquid pipelines (6) are arranged at the upper ends of the cover plate (3) and are connected and communicated with the liquid inlet pipes (31), first electric control valves are respectively arranged at the lower ends of the liquid inlet pipes (31), and inlets of the liquid pipelines (6) are connected with liquid pumps matched with the liquid bottles through hoses.
2. The fully automated nucleic acid molecule hybridization apparatus according to claim 1, wherein: the intelligent control system is characterized by further comprising a controller, wherein the controller is arranged in the casing (1), a touch screen connected with the controller is arranged on the outer surface of the casing (1), and the first electric control valves are respectively connected with the controller.
3. The fully automated nucleic acid molecule hybridization apparatus according to claim 2, wherein: the first lifting mechanism (7) comprises a plurality of first electric push rods, a controller with a screen is arranged in the shell (1), and the first electric push rods are connected with the controller.
4. The fully automated nucleic acid molecule hybridization apparatus according to claim 2, wherein: the second lifting mechanism (8) comprises a plurality of second electric push rods, and the second electric push rods are connected with the controller.
5. The fully automated nucleic acid molecule hybridization apparatus according to claim 2, wherein: the liquid distributor is characterized by further comprising a flow divider (9), wherein a flow passage is arranged inside the flow divider (9), a liquid outlet communicated with the flow passage and a plurality of liquid inlets communicated with the flow passage are formed in the surface of the flow divider, the liquid outlet is connected and communicated with the liquid inlet pipe (31), the liquid inlets are respectively connected with each liquid pump matched with the liquid agent bottle through hoses, and a second electric control valve is respectively arranged at the liquid inlet and connected with the controller.
6. The fully automated nucleic acid molecule hybridization apparatus according to claim 2, wherein: an interlayer cavity is arranged in the reaction box (2), an electric heating device (24) is arranged in the interlayer cavity, and the electric heating device (24) is connected with the controller.
7. The fully automated nucleic acid molecule hybridization apparatus according to claim 2, wherein: the lower end of the cover plate (3) is embedded with a plurality of ultraviolet light sources which are respectively connected with the controller.
8. The fully automated nucleic acid molecule hybridization apparatus according to claim 1, wherein: the bottom wall of the waste liquid tank (4) is a conical surface, and the tip of the conical surface falls at the liquid leakage port.
9. The fully automated nucleic acid molecule hybridization apparatus according to any one of claims 1 to 8, wherein: the plugging block (41) comprises a vertical connecting column (411) and a silica gel plug (412), wherein the connecting column (411) is fixed on the inner bottom wall of the waste liquid tank (4), and the silica gel plug (412) is wrapped and arranged outside the connecting column (411).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310881120.6A CN117089438A (en) | 2023-07-18 | 2023-07-18 | Full-automatic nucleic acid molecule hybridization instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310881120.6A CN117089438A (en) | 2023-07-18 | 2023-07-18 | Full-automatic nucleic acid molecule hybridization instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117089438A true CN117089438A (en) | 2023-11-21 |
Family
ID=88768825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310881120.6A Pending CN117089438A (en) | 2023-07-18 | 2023-07-18 | Full-automatic nucleic acid molecule hybridization instrument |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117089438A (en) |
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2023
- 2023-07-18 CN CN202310881120.6A patent/CN117089438A/en active Pending
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