CN117085084B - 一种肚脐贴及其制备方法 - Google Patents
一种肚脐贴及其制备方法 Download PDFInfo
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- CN117085084B CN117085084B CN202311294355.1A CN202311294355A CN117085084B CN 117085084 B CN117085084 B CN 117085084B CN 202311294355 A CN202311294355 A CN 202311294355A CN 117085084 B CN117085084 B CN 117085084B
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- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及医疗用品领域，具体为一种肚脐贴及其制备方法，包括表面涂布胶粘剂的粘贴单元；起固定作用的环形束缚单元；位于所述环形束缚单元内的药物单元和发热单元；及离型膜；所述药物单元的制备原料包括：生晒参20‑25份、鹿茸3‑6份、灵芝1‑2份、天门冬12‑15份、枸杞子5‑10份、肉苁蓉6‑10份、柏子仁3‑5份、山药8‑12份、熟地黄3‑6份、黄芪10‑15份、金银花2‑5份、山茱萸5‑10份、龙骨1‑2份、薄荷叶10‑20份、马钱子3‑5份、辅料0‑10份，本发明制备的肚脐贴能够显著增加氢化可的松导致的肾阳虚小鼠的性器官的脏器系数，提高交配能力，具有明显的补肾壮阳作用。
Description
技术领域
本发明涉及医疗用品领域，具体为一种肚脐贴及其制备方法。
背景技术
脐在腹部中央，中医称之“神阙穴”，寓意为神仙居住的地方，又名气舍、维会，为任脉所生，任脉总领人一身阴经，循行于胸腹正中，上联心肺，中经脾胃，下至会阴，所以神阙为经气的汇海，乃人体上下交会之中心。它与人体十二经脉相连、五脏六腑相通，是心肾交通的“门户”，被历代养生家誉为保健养生“要塞”，中医称之为十二经络之根、呼吸之门。
“脐疗”，是将药物放在脐中(神阙穴)，上面用胶布或纱布等覆盖固定，用以防治疾病的一种方法。其中最经典，流传到现在我们使用起来最普遍温和的，就是南怀瑾老先生在《我说参同契》里的秘方记载了：用桂圆肉，花椒，艾绒，捣碎混合在一起，睡觉敷在肚脐上，向全身传达真阳之气。
目前“脐疗”多用于治疗小儿胀气、增强脾胃机能，未见有能补肾壮阳的报道。
发明内容
发明目的：针对上述技术问题，本发明提出了一种肚脐贴及其制备方法。
所采用的技术方案如下：
一种肚脐贴，包括表面涂布胶粘剂的粘贴单元；
起固定作用的环形束缚单元；
位于所述环形束缚单元内的药物单元和发热单元；
及离型膜；
以重量份数计，所述药物单元的制备原料包括：
生晒参20-25份、鹿茸3-6份、灵芝1-2份、天门冬12-15份、枸杞子5-10份、肉苁蓉6-10份、柏子仁3-5份、山药8-12份、熟地黄3-6份、黄芪10-15份、金银花2-5份、山茱萸5-10份、龙骨1-2份、薄荷叶10-20份、马钱子3-5份、辅料0-10份。
进一步地，以重量份数计，所述药物单元的制备原料包括：
生晒参25份、鹿茸5份、灵芝2份、天门冬12份、枸杞子8份、肉苁蓉10份、柏子仁3份、山药8份、熟地黄5份、黄芪12份、金银花4份、山茱萸6份、龙骨1份、薄荷叶20份、马钱子3份、辅料8份。
进一步地，所述发热单元包括包括离子液体型聚合物固体电解质、无机盐、还原铁粉和活性炭。
进一步地，所述离子液体型聚合物固体电解质、还原铁粉、无机盐和活性炭的质量比为5-10：0.3-0.5：3-5：1。
进一步地，所述离子液体型聚合物固体电解质的制备方法如下：
氮气保护下，将N-乙烯基咪唑、溴乙酸甲酯、乙醇混合搅拌升温至65-75℃反应18-24h后冷却至室温，减压浓缩得到中间体A，氮气保护下，将中间体A、偶氮二异丁腈加入DMF中搅拌升温至65-75℃反应18-24h后冷却至室温，所得反应液倒入乙醚中，室温搅拌10-20h后过滤，得到中间体B，将中间体B加入水中搅拌溶解后再加入双三氟甲烷磺酰亚胺锂，室温搅拌3-5h，静置分层，取下层多次水洗后，真空干燥至恒重即可。
进一步地，所述辅料包括氧化锌、凡士林、羊毛脂和石蜡。
进一步地，所述氧化锌、凡士林、羊毛脂和石蜡的质量比为0.1-0.5：1-3：2-4：1-3。
本发明还提供了一种肚脐贴的制备方法：
将离子液体型聚合物固体电解质、还原铁粉、无机盐、活性炭混合均匀后压制，得到与所述环形束缚单元相匹配的发热单元，取生晒参、鹿茸、灵芝、天门冬、枸杞子、肉苁蓉、柏子仁、山药、熟地黄、黄芪、金银花、山茱萸、龙骨、薄荷叶、马钱子晒干后粉碎处理，加水煎煮取汁，加入辅料后减压浓缩得到稠膏，将稠膏均匀涂覆于所述发热单元表面，将所述环形束缚单元粘贴在所述粘贴单元上，再将涂覆有稠膏的发热单元固定在所述环形束缚单元内，最后粘上离型膜隔绝空气即可。
进一步地，发热单元制作时须在氮气保护下进行。
进一步地，加水煎煮时进行超声振荡。
本发明的有益效果：
本发明提供了一种肚脐贴，其中生晒参、灵芝和柏子仁能够安神增智，补脾益肺，鹿茸和肉苁蓉具有壮肾阳，益精血的作用，天门冬、金银花和薄荷叶疏散风热、养阴润燥能够调和药性，枸杞子滋补肝肾，益精明目，山药有补脾养胃，生津益肺，补肾涩精的功效，熟地黄能够滋阴，补血，黄芪能够补气升阳、固表止汗，山茱萸具有补益肝肾、收涩固脱的功效，龙骨具有镇惊安神，平肝潜阳，收敛固涩的功效，马钱子能够舒经活络，增强药效，经测试，本发明肚脐贴具有明显的补肾壮阳作用，能够增加动物机体生理功能，提高小鼠交配能力，能明显改善肾阳虚症状，具有补肾、壮阳的药理作用，发热单元的加入能够通过敷贴的热力提高肚脐贴药性成分的透皮渗透率，达到提高补肾壮阳效果的作用。
附图说明
图1为本发明实施例1中肚脐贴的结构示意图；
图中标号分别代表：
1-粘贴单元、2-胶粘剂、3-环形束缚单元、4-发热单元、5-药物单元、6-离型膜。
图2为本发明实施例1中发热单元的放热曲线图。
具体实施方式
实施例中未注明具体条件者，按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者，均为可以通过市售购买获得的常规产品。本发明未提及的技术均参照现有技术。
实施例1：
一种肚脐贴，包括表面涂布胶粘剂2(水性压敏胶)的粘贴单元1(弹力无纺布)；
起固定作用的环形束缚单元3(圆环形聚氨酯塑料)；
位于所述环形束缚单元内的药物单元5和发热单元4；
及离型膜6；
以重量份数计，药物单元5的制备原料包括：
生晒参25份、鹿茸5份、灵芝2份、天门冬12份、枸杞子8份、肉苁蓉10份、柏子仁3份、山药8份、熟地黄5份、黄芪12份、金银花4份、山茱萸6份、龙骨1份、薄荷叶20份、马钱子3份、氧化锌0.5份、凡士林2份、羊毛脂3.5份、石蜡2份。
发热单元4包括包括质量比为5-10：0.4：5：1的离子液体型聚合物固体电解质、氯化钠、还原铁粉和活性炭。
其中，离子液体型聚合物固体电解质的制备方法如下：
氮气保护下，将7.06g N-乙烯基咪唑、11.47g溴乙酸甲酯、80mL乙醇混合搅拌升温至72℃反应24h后冷却至室温，减压浓缩得到中间体A，氮气保护下，将5g中间体A、0.05g偶氮二异丁腈加入50mL DMF中搅拌升温至70℃反应20h后冷却至室温，所得反应液倒入500mL乙醚中，室温搅拌15h后过滤，得到中间体B，将中间体B加入250mL水中搅拌溶解后再加入5g双三氟甲烷磺酰亚胺锂，室温搅拌5h，静置分层，取下层多次水洗后，真空干燥至恒重即可。
上述肚脐贴的制备方法：
氮气保护下，将离子液体型聚合物固体电解质、还原铁粉、无机盐、活性炭混合均匀后5MPa压制15s，得到与环形束缚单元形状相匹配的发热单元，取生晒参、鹿茸、灵芝、天门冬、枸杞子、肉苁蓉、柏子仁、山药、熟地黄、黄芪、金银花、山茱萸、龙骨、薄荷叶、马钱子晒干后粉碎处理过200目筛网，400W超声振荡下加水煎煮取汁，向所得料汁中加入氧化锌、凡士林、羊毛脂、石蜡后减压浓缩得到稠膏，将稠膏均匀涂覆于发热单元表面，将环形束缚单元粘贴在粘贴单元上，再将涂覆有稠膏的发热单元固定在环形束缚单元内，最后粘上离型膜隔绝空气即可。
实施例2：
与实施例1基本相同，区别在于，以重量份数计，药物单元的制备原料包括：
生晒参20-25份、鹿茸3-6份、灵芝1-2份、天门冬12-15份、枸杞子5-10份、肉苁蓉6-10份、柏子仁3-5份、山药8-12份、熟地黄3-6份、黄芪10-15份、金银花2-5份、山茱萸5-10份、龙骨1-2份、薄荷叶10-20份、马钱子3-5份、氧化锌0.5份、凡士林2份、羊毛脂3.5份、石蜡2份。
实施例3：
与实施例1基本相同，区别在于，以重量份数计，药物单元的制备原料包括：
生晒参20-25份、鹿茸3-6份、灵芝1-2份、天门冬12-15份、枸杞子5-10份、肉苁蓉6-10份、柏子仁3-5份、山药8-12份、熟地黄3-6份、黄芪10-15份、金银花2-5份、山茱萸5-10份、龙骨1-2份、薄荷叶10-20份、马钱子3-5份、氧化锌0.5份、凡士林2份、羊毛脂3.5份、石蜡2份。
实施例4：
与实施例1基本相同，区别在于，以重量份数计，药物单元的制备原料包括：
生晒参20-25份、鹿茸3-6份、灵芝1-2份、天门冬12-15份、枸杞子5-10份、肉苁蓉6-10份、柏子仁3-5份、山药8-12份、熟地黄3-6份、黄芪10-15份、金银花2-5份、山茱萸5-10份、龙骨1-2份、薄荷叶10-20份、马钱子3-5份、氧化锌0.5份、凡士林2份、羊毛脂3.5份、石蜡2份。
实施例5：
与实施例1基本相同，区别在于，以重量份数计，药物单元的制备原料包括：
生晒参20-25份、鹿茸3-6份、灵芝1-2份、天门冬12-15份、枸杞子5-10份、肉苁蓉6-10份、柏子仁3-5份、山药8-12份、熟地黄3-6份、黄芪10-15份、金银花2-5份、山茱萸5-10份、龙骨1-2份、薄荷叶10-20份、马钱子3-5份、氧化锌0.5份、凡士林2份、羊毛脂3.5份、石蜡2份。
性能测试：
体重接近(20±2g)的健康成年昆明种雄性小鼠，随机分为6组，每组10只，分别为实验组1-3及对照组1-3，除对照组2皮下注射生理盐水5mL/kg外，其余各组均注射氢化可的松25mg/kg，每日1次，连续7d，造模；
测试前1d用脱毛膏给小鼠腹部脱毛，备皮面积约为3cm×3cm，备皮区域清洗干净，实验组1-3分别用实施例1-3所制备的肚脐贴固定牢固，24h更换1次，连续用药15d，对照组1和2用实施例1中所制备不含药物单元的肚脐贴固定牢固，对照组3用无纺布固定牢固；
健康成年昆明种雌性小鼠于交配测试前48h和前3d按照0.2ml/10g灌胃补佳乐混悬液，使之发情，交配测试时，将雄性小鼠单独放入笼中，使其适应环境5min，然后放入1只雌鼠，观察并记录雄鼠首次捕捉雌鼠的时间、20min内雄鼠捕捉雌鼠的次数、20min内交配次数；
次日，脱颈椎处死雄性小鼠，迅速分离睾丸、附睾，剖取精囊腺、包皮腺称湿重，计算脏器系数；
测试结果如下表1所示：
表1：
由上表1可知，本发明制备的肚脐贴能够显著增加氢化可的松导致的肾阳虚小鼠的性器官的脏器系数，提高交配能力，具有明显的补肾壮阳作用。
以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
Claims (5)
1.一种补肾壮阳的肚脐贴，其特征在于，包括表面涂布胶粘剂的粘贴单元；
起固定作用的环形束缚单元；
位于所述环形束缚单元内的药物单元和发热单元；
及离型膜；
以重量份数计，所述药物单元由以下原料制备而成：
生晒参20-25份、鹿茸3-6份、灵芝1-2份、天门冬12-15份、枸杞子5-10份、肉苁蓉6-10份、柏子仁3-5份、山药8-12份、熟地黄3-6份、黄芪10-15份、金银花2-5份、山茱萸5-10份、龙骨1-2份、薄荷叶10-20份、马钱子3-5份、辅料0-10份；
所述发热单元包括离子液体型聚合物固体电解质、无机盐、还原铁粉和活性炭；
所述离子液体型聚合物固体电解质、还原铁粉、无机盐和活性炭的质量比为5-10：0.3-0.5：3-5：1；
所述离子液体型聚合物固体电解质的制备方法如下：
氮气保护下，将N-乙烯基咪唑、溴乙酸甲酯、乙醇混合搅拌升温至65-75℃反应18-24h后冷却至室温，减压浓缩得到中间体A，氮气保护下，将中间体A、偶氮二异丁腈加入DMF中搅拌升温至65-75℃反应18-24h后冷却至室温，所得反应液倒入乙醚中，室温搅拌10-20h后过滤，得到中间体B，将中间体B加入水中搅拌溶解后再加入双三氟甲烷磺酰亚胺锂，室温搅拌3-5h，静置分层，取下层多次水洗后，真空干燥至恒重即可；
所述辅料包括氧化锌、凡士林、羊毛脂和石蜡；
所述氧化锌、凡士林、羊毛脂和石蜡的质量比为0.1-0.5：1-3：2-4：1-3。
2.如权利要求1所述的肚脐贴，其特征在于，以重量份数计，所述药物单元由以下原料制备而成：
生晒参25份、鹿茸5份、灵芝2份、天门冬12份、枸杞子8份、肉苁蓉10份、柏子仁3份、山药8份、熟地黄5份、黄芪12份、金银花4份、山茱萸6份、龙骨1份、薄荷叶20份、马钱子3份、辅料8份。
3.一种如权利要求1或2所述的补肾壮阳的肚脐贴的制备方法，其特征在于，将离子液体型聚合物固体电解质、还原铁粉、无机盐、活性炭混合均匀后压制，得到与所述环形束缚单元相匹配的发热单元，取生晒参、鹿茸、灵芝、天门冬、枸杞子、肉苁蓉、柏子仁、山药、熟地黄、黄芪、金银花、山茱萸、龙骨、薄荷叶、马钱子晒干后粉碎处理，加水煎煮取汁，加入辅料后减压浓缩得到稠膏，将稠膏均匀涂覆于所述发热单元表面，将所述环形束缚单元粘贴在所述粘贴单元上，再将涂覆有稠膏的发热单元固定在所述环形束缚单元内，最后粘上离型膜隔绝空气即可。
4.如权利要求3所述的肚脐贴的制备方法，其特征在于，发热单元制作时须在氮气保护下进行。
5.如权利要求3所述的肚脐贴的制备方法，其特征在于，加水煎煮时进行超声振荡。
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