CN117069557A - Preparation method of deuterated 3-formylindole - Google Patents

Preparation method of deuterated 3-formylindole Download PDF

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CN117069557A
CN117069557A CN202310933506.7A CN202310933506A CN117069557A CN 117069557 A CN117069557 A CN 117069557A CN 202310933506 A CN202310933506 A CN 202310933506A CN 117069557 A CN117069557 A CN 117069557A
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bromide
hydrogen
deuterated
formylindole
peroxide
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吕少英
王彬
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Deuterium Yiyou Deuterium Tianjin Pharmaceutical Co ltd
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Deuterium Yiyou Deuterium Tianjin Pharmaceutical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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Abstract

The invention provides a preparation method of deuterated 3-formylindole, which comprises the steps of dissolving a compound I and a compound II in deuterated water, and reacting under the conditions of bromide and an oxidant to generate a compound III, wherein a catalyst selected in the preparation method of deuterated 3-formylindole is cheap and easy to obtain, the cost is low, a deuterium source is deuterated water, the price is cheap and easy to obtain, the reaction is carried out at room temperature under mild reaction conditions, the reaction is simple, high-temperature heating is not needed, a noble metal catalyst is not needed, the reaction yield is improved, the deuteration degree is 90-99%, and the yield is high and can be fully utilized for the deuterium source.

Description

Preparation method of deuterated 3-formylindole
Technical Field
The invention belongs to the field of compound synthesis, and particularly relates to a preparation method of deuterated 3-formylindole.
Background
Deuterated compounds are increasingly important in mass spectrometry, reaction mechanism exploration, biological metabolic process discovery, and the use of deuterated drugs, where deuterated drugs may improve pharmacokinetic and/or toxicity properties, potentially more effective and safer than non-deuterated drugs. The 3-formylindole is an important intermediate in organic synthesis, various bioactive molecules can be prepared, and after deuterium replacement is carried out on hydrogen of aldehyde group, the C1 deuterated 3-formylindole can be provided, and has important significance in construction of various molecules.
The existing synthesis method is mainly based on Vilsmeier-Haack reaction 1, but the deuterium source is full deuterated DMF, and the price is high; the formylation reaction 2 catalyzed by visible light needs to use a less-common photocatalyst; photocatalytic formylation of glyoxylate 3 the required deuterium source is expensive perdeuterated glyoxylate. The above methods either have deuterium sources that are not readily available or require photocatalysts and special conditions for the reaction.
Disclosure of Invention
In view of this, the present invention aims to propose a preparation method of deuterated 3-formylindole, so as to solve the problems of difficult availability of deuterium sources, and the need of a photocatalyst and special conditions for the reaction in the prior art.
In order to achieve the above purpose, the technical scheme of the invention is realized as follows:
a process for preparing deuterated 3-formylindoles comprising the steps of: dissolving a compound I and a compound II in deuterated water, and reacting under the conditions of bromide and an oxidant to generate a compound III;
the compound I is of the formula One of the following;
compound ii formula:
compound iii formula: one of the following;
the substituent of R1 is one of hydrogen, alkyl, benzyl, tert-butoxycarbonyl, acetyl, aryl and alkenyl;
the substituent of R2 is one of hydrogen, alkyl, ester, aldehyde, alkyl oxygen, aryl oxygen, alkyl nitrogen, aryl nitrogen, alkynyl, alkene, cyano, nitro, halogen, aryl, heteroaryl and heterocycle;
r3 is one of alkyl, aryl and hydrogen;
r4 is one of alkyl, aryl and hydrogen;
r5 is one of alkyl, aryl and hydrogen.
The preparation method of deuterated 3-formylindole comprises the following preparation methods:
s1: dissolving a compound I in deuterated water, adding a compound II and a bromide catalyst, adding an oxidant into the mixture, and stirring for a period of time at room temperature;
s2: stopping adding the oxidant after the consumption of the reactant, extracting the obtained mixture by using an organic solvent, and recovering deuterated water at the lower layer; the organic phase is post-treated to obtain the product.
The preparation and synthesis route of the compound III is as follows:
preferably, the compound III is prepared by the synthetic route of
The post-treatment in the step S2 comprises washing, drying and filtering, and the obtained organic phase is distilled off the solvent.
Further, the bromide comprises one of N-bromosuccinimide, tetrabutylammonium bromide, hydrogen bromide, ammonia bromide, tetraoctylammonium bromide, tetra-N-butylphosphorus bromide, dibromotetrachloroethane and metal bromide;
the metal bromide comprises one of lithium bromide, potassium bromide, sodium bromide, copper bromide, ferric bromide, calcium bromide, aluminum bromide, magnesium bromide, strontium bromide, cobalt bromide and cesium bromide.
Further, the bromide is N-bromosuccinimide.
Further, the oxidant is an aqueous solution of oxygen and peroxide;
the peroxide comprises one of metal peroxide, hydrogen peroxide and organic peroxide;
the metal peroxide comprises sodium peroxide, oxone, K 2 S 2 O 8 One of the following;
the organic peroxide comprises one of dialkyl peroxide, peroxyester, peroxycarbonate, peroxybenzoic acid, and ketone peroxide.
Further, the oxidant is an aqueous solution of oxygen and hydrogen peroxide.
Further, R4 is hydrogen, R5 is aryl, preferably R4 is hydrogen, and R5 is a benzene ring.
Preferably, R3 is one of alkyl or hydrogen, more preferably, R3 is one of methane or hydrogen.
R1 is one of hydrogen, benzyl, tert-butyloxycarbonyl and acetyl; preferably, R2 is one of hydrogen, hydroxy, alkoxy, carboxy, carboxylate.
More preferably, compound II is N-methylaniline.
Further, the deuteration degree of the compound III obtained by the preparation method is 90-99%.
Compared with the prior art, the preparation method of the deuterated 3-formylindole has the following advantages:
1. the catalyst selected by the preparation method of the deuterated 3-formylindole is cheap and easy to obtain, and the cost is low.
2. The deuterium source of the patent is deuterium water, and the price is low and the deuterium source is easy to obtain.
3. The preparation method of the C1 deuterated 3-formylindole is carried out at room temperature, the reaction condition is mild, the reaction is simple, high-temperature heating is not needed, and the energy can be saved.
4. The reaction yield of the preparation method of the C1 deuterated 3-formylindole can be improved, the deuteration degree is 90-99%, and the yield is high and can be fully utilized for deuterium sources.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention. In the drawings:
FIG. 1 is a graph of data characterization of the product of example 1;
FIG. 2 is a nuclear magnetic resonance spectrum of normal 3-formylindole.
Detailed Description
It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other.
The invention will be described in detail below with reference to the drawings in connection with embodiments.
Example 1:
1.17 (10 mmol,1 equiv) g of indole was added to 25 ml of deuterated water, 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst dose here; no error; 10% mmol) were added respectively, the mixture was purged with oxygen and stirred at room temperature for 5 hours, TLC detected that the reaction was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation and the residue was subjected to column chromatography to give C1-3 formylindole 1.37 g in 94% yield and 98% deuteration.
The synthetic route for example 1 is as follows:
data characterisation of the product of example 1, as shown in figure 1: 1H-NMR (DMSO-d 6,400 MHz) 9.94 (s, 1H), 8.29 (s, 1H), 8.10 (d, 7.2Hz, 1H), 7.51 (d, 8.0Hz, 1H), 7.28-7.20 (m, 2H); 13C-NMR (DMSO-d 6,100 MHz): 185.00,138.53,137.07,124.14,123.49,122.16,120.85,118.18,112.45; FIG. 2 is a nuclear magnetic resonance spectrum of normal 3-formylindole, and the deuteration ratio can be demonstrated by comparing the two graphs.
Example 2:
1.17 (10 mmol,1 equiv) g of indole was added to 25 ml of deuterated water, 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.32 g of tetrabutylammonium bromide (10% mmol) were added respectively, the mixture was purged with oxygen and stirred at room temperature for 5 hours, TLC detected that the reaction was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation and the residue was subjected to column chromatography to give C1-3 formylindole 1.37 g, yield 90%, deuteration degree 99%.
Example 3:
1.17 (10 mmol,1 equiv) g of indole was added to 25 ml of deuterated water, 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.09 g of lithium bromide (10% mmol) were added respectively, oxygen was added to the mixture, stirring was carried out at room temperature for 5 hours, TLC detected that the reactants were depleted, and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, and the resulting organic phase was subjected to solvent evaporation and column chromatography to give C1-3 formylindole 1.37 g, yield 90%, deuteration 90%.
Example 4:
1.17 (10 mmol,1 equiv) g of indole was added to 25 ml of deuterated water, 1.8 g of N, N-dimethylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (10% mmol) were added respectively, the mixture was purged with oxygen and stirred at room temperature for 5 hours, TLC detected that the reaction was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation and the residue was subjected to column chromatography to give C1-3 formylindole 1.37 g in 95% yield and 99% deuteration.
Example 5:
1.17 (10 mmol,1 equiv) g of indole was added to 25 ml of deuterated water, 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (10% mmol) were added respectively, 2.1 ml (70%, 20mmol,2 equiv) of tert-butanol were added to the mixture and stirred at room temperature for 5 hours, TLC was checked, the consumption of the reactants was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, and the resulting organic phase was subjected to solvent evaporation and column chromatography to give C1-3 formylindole 1.37 g, 93% yield, 96% deuteration.
Example 6:
will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 90% and the deuteration degree was 98%.
Example 7
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the productThe yield was 87% and the deuteration degree was 96%.
Example 8
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 91% and the deuteration degree was 92%.
Example 9
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (here for the catalyst)The measurement is correct; 10% mmol) and the mixture was purged with oxygen and stirred at room temperature for 5 hours, and TLC was checked to see that the reaction was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the productThe yield was 75% and the deuteration degree was 95%.
Example 10
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the productThe yield was 95% and the deuteration degree was 95%.
Example 11
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. Organic compoundThe phases were washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and filtered, the resulting organic phase was subjected to solvent evaporation and the residue was subjected to column chromatography to give the productThe yield was 97% and the deuteration degree was 98%.
Example 12
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 82% and the deuteration degree was 90%.
Example 13
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 90% and the deuteration degree was 92%.
Example 14
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the productThe yield was 75% and the deuteration degree was 93%.
Example 15
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the productThe yield was 92% and the deuteration degree was 93%.
Example 16
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 69% and the deuteration degree was 94%.
Example 17
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 50% and the deuteration degree was 91%.
Example 18
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount here, noError; 10% mmol) and the mixture was purged with oxygen and stirred at room temperature for 5 hours, and TLC was checked to see that the reaction was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 92% and the deuteration degree was 88%.
Example 19
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 73% and the deuteration degree was 98%.
Example 20
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. Organic compoundThe phases were washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation and the residue was subjected to column chromatography to give the product +.>The yield was 98% and the deuteration degree was 90%.
Example 21
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 95% and the deuteration degree was 92%.
Example 22
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 96% and the deuteration degree was 98%.
Example 23
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 92% and the deuteration degree was 88%.
Example 24
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 95% and the deuteration degree was 96%.
Example 25
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 97% and the deuteration degree was 91%.
Example 26
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 82% and the deuteration degree was 86%.
Example 27
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (here for the catalyst)The measurement is correct; 10% mmol) and the mixture was purged with oxygen and stirred at room temperature for 5 hours, and TLC was checked to see that the reaction was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 80% and the deuteration degree was 91%.
Example 28
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 74% and the deuteration degree was 94%.
Example 29
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate to recover the deuterated water of the lower layer. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 68% and the deuteration degree was 91%.
Example 30
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 90% and the deuteration degree was 90%.
Example 31
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated saline, dried over anhydrous Na2SO4, and then filtered, the obtained organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the product +.>The yield was 91% and the deuteration degree was 90%.
Example 32
Will 10mmolTo 25 ml of deuterated water were added 1.6 g of N-methylaniline (15 mmol,1.5 equiv) and 0.18 g of NBS (catalyst amount, here; 10% mmol) respectively, and the mixture was purged with oxygen and stirred at room temperature for 5 hours, after which TLC detected that the reactant was depleted and the oxygen supply was stopped. The resulting mixture was extracted 3 times with ethyl acetate and the lower deuterated water was recovered. The organic phase was washed with NaHCO3 and saturated brine, dried over anhydrous Na2SO4, and then filtered, the resulting organic phase was subjected to solvent evaporation, and the residue was subjected to column chromatography to give the productThe yield was 80% and the deuteration degree was 93%.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.

Claims (10)

1. A process for the preparation of deuterated 3-formylindoles, characterized in that: the method comprises the following steps: dissolving a compound I and a compound II in deuterated water, and reacting under the conditions of bromide and an oxidant to generate a compound III;
the compound I is of the formula One of the following;
compound ii formula:
the substituent of R1 is one of hydrogen, alkyl, benzyl, tert-butoxycarbonyl, acetyl, aryl and alkenyl;
the substituent of R2 is one of hydrogen, alkyl, ester, aldehyde, alkyl oxygen, aryl oxygen, alkyl nitrogen, aryl nitrogen, alkynyl, alkene, cyano, nitro, halogen, aryl, heteroaryl and heterocycle;
r3 is one of alkyl, aryl and hydrogen;
r4 is one of alkyl, aryl and hydrogen;
r5 is one of alkyl, aryl and hydrogen.
2. The method for preparing deuterated 3-formylindole according to claim 1, wherein: the bromide comprises one of N-bromosuccinimide, tetrabutylammonium bromide, hydrogen bromide, ammonium bromide, tetraoctylammonium bromide, tetra-N-butyl phosphorus bromide, dibromotetrachloroethane and metal bromide;
the metal bromide comprises one of lithium bromide, potassium bromide, sodium bromide, copper bromide, ferric bromide, calcium bromide, aluminum bromide, magnesium bromide, strontium bromide, cobalt bromide and cesium bromide.
3. The method for preparing deuterated 3-formylindole according to claim 1, wherein: the bromide is N-bromosuccinimide.
4. The method for preparing deuterated 3-formylindole according to claim 1, wherein: the oxidant is oxygen or aqueous solution of peroxide.
5. The method for preparing deuterated 3-formylindole according to claim 4, wherein: the peroxide comprises one of metal peroxide, hydrogen peroxide and organic peroxide;
the metal peroxide comprises sodium peroxide, oxone, K 2 S 2 O 8 One of the following;
the organic peroxide comprises one of dialkyl peroxide, peroxyester, peroxycarbonate, peroxybenzoic acid, and ketone peroxide.
6. The method for preparing deuterated 3-formylindole according to claim 1, wherein: the oxidant is oxygen or hydrogen peroxide water solution.
7. The method for preparing deuterated 3-formylindole according to claim 1, wherein: r4 is hydrogen and R5 is aryl.
Preferably, R3 is one of alkyl or hydrogen, more preferably, R3 is one of methane or hydrogen;
r1 is one of hydrogen, benzyl, tert-butyloxycarbonyl and acetyl; preferably, R2 is one of hydrogen, hydroxy, alkoxy, carboxy, carboxylate.
8. The method for preparing deuterated 3-formylindole according to claim 1, wherein: r4 is hydrogen and R5 is benzene ring.
9. The method for preparing deuterated 3-formylindole according to claim 1, wherein: the compound II is N-methylaniline.
10. The method for preparing deuterated 3-formylindole according to claim 1, wherein: the deuteration degree of the compound III obtained by the preparation method is 90-99%.
CN202310933506.7A 2023-07-27 2023-07-27 Preparation method of deuterated 3-formylindole Pending CN117069557A (en)

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