CN117064749A

CN117064749A - Split type double-chamber air pressure balanced liquid medicine transfer device

Info

Publication number: CN117064749A
Application number: CN202311115785.2A
Authority: CN
Inventors: 陈日志; 陈伟权; 唐秉华; 杨丽臻; 罗荣琼; 郑良宇
Original assignee: Zhanjiang Jianliyuan Medical Supplies Co ltd
Current assignee: Zhanjiang Jianliyuan Medical Supplies Co ltd
Priority date: 2023-08-31
Filing date: 2023-08-31
Publication date: 2023-11-17

Abstract

The invention discloses a split type double-chamber air pressure balanced liquid medicine transfer device which comprises a component I and a component II, wherein the component I comprises a first syringe, a first needle seat and a dispensing needle component, and the component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat; and in the fixed connection state of the component I and the component II, the puncture needle of the component II pierces the sealing plug in the air window of the component I and is communicated with the second channel in the first needle seat. The further improved liquid medicine transfer device can be conveniently applied to the injection equipment to carry out quantitative liquid medicine transmission on the basis of keeping the characteristics of tightness, air pressure balance and the like.

Description

Split type double-chamber air pressure balanced liquid medicine transfer device

Technical Field

The invention relates to the field of medical dispensing pipetting devices, in particular to a split type liquid medicine transfer device with double-chamber air pressure balance.

Background

Dangerous drugs, represented by chemotherapeutic drugs, are extremely dangerous to health of medical personnel engaged in the formulation and transport of such drugs for a long period of time. Some medical institutions build various facilities such as clean rooms and biological cabinets to reduce the risk of drug leakage, and the investment is large but the actual popularization and application effects are poor.

Chinese patent publication No. CN115607444B (CN 202211220305.4) discloses a double-chamber circulation sealed type liquid medicine transfer device and liquid medicine transfer system. The dispensing device is provided with the double-chamber injector, wherein one chamber is used for infusing liquid, the other chamber is used for balancing air pressure, the tightness of the dispensing process is effectively ensured, and the leakage risk is reduced.

Another application of drug fluid transfer devices (i.e. dispensers) is the realization of metered doses in a drug delivery device as a source of drug delivery. Generally, such dispensing devices require that the dispenser be mounted to a bolus device (e.g., a bolus device of the type WZS-50F6 for Medfusion, and a bolus device of the type SYS-52 for MEDCAPTAIN) that controls the amount/rate of infusion after the medicament is dispensed, the bolus device holding the syringe of the dispenser while pushing the plunger rod at a predetermined rate to effect a metered infusion. If the dual chamber syringe is directly mounted to the injection device, both piston rods will be pushed simultaneously, rendering the injection device inoperable or occupying space, thereby affecting the normal operation of other accessories.

Disclosure of Invention

Aiming at the problem that the novel medicine dispenser cannot be applied to the existing injection equipment, the invention aims to provide a split type double-chamber air pressure balanced medicine liquid transfer device. The further improved liquid medicine transfer device can be conveniently applied to the injection equipment to carry out quantitative liquid medicine transmission on the basis of keeping the characteristics of tightness, air pressure balance and the like.

In order to achieve the above purpose, the present invention adopts the following technical scheme.

A split type double-chamber air pressure balanced liquid medicine transfer device, comprising a component I and a component II, wherein:

the component I comprises a first syringe, a first needle seat and a dispensing needle component, wherein the first needle seat is fixedly connected with the first syringe through a connector on the first syringe, and the dispensing needle component is fixedly connected on the first needle seat;

the inside of the first needle seat is provided with a first channel and a second channel, the side surface is provided with a transom, and the tail end is provided with a cavity for connecting and fixing with a connector on the first syringe; the tail end of the first channel is communicated with the cavity, and the tail end of the second channel is communicated with the louver; a sealing plug is arranged in the transom;

the dispensing needle assembly comprises an infusion channel and an exhaust channel, wherein the infusion channel is communicated with the first channel, and the exhaust channel is communicated with the second channel;

the component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat;

in the fixed connection state of the component I and the component II, the puncture needle of the component II pierces the sealing plug in the air window of the component I and is communicated with the second channel in the first needle seat;

when the component I and the component II are separated, the sealing plug in the air window enables the air window to be in a sealing state.

In the present invention, unless otherwise indicated, when describing the structure of the assembly, the front end refers to the end to which the needle tip of the needle and/or the puncture needle is directed, and the rear end (or tip) refers to the opposite end.

The structure of a syringe is readily known and ascertainable to those skilled in the art and generally includes a syringe barrel and a plunger rod that is slidable back and forth along a lumen within the syringe barrel. Specifically, the first injector comprises a first injection cylinder and a first piston rod which can slide back and forth along the inner cavity in the first injection cylinder; the second syringe includes a second syringe barrel and a second piston rod slidable back and forth along the interior cavity within the second syringe barrel.

Preferably, in the fixedly connected state of the component I and the component II, the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction mode. Further preferably, a fastening structure is provided on an outer wall of at least one of the first syringe and the second syringe, so that the first syringe and the second syringe are detachably fixed to each other when being arranged side by side and in the same direction. More preferably, at least one of the first syringe and the second syringe is provided with a support portion on the wall of the barrel, and an end structure of the support portion is matched with an outer side wall of the opposite syringe, so that the first syringe and the second syringe are mutually supported by the support portion when being arranged side by side and in the same direction.

In the split type double-chamber air pressure balanced liquid medicine transfer device, the component I comprises a first injector, a first needle seat and a dispensing needle component.

Inside the first needle seat, the end of the second channel is communicated with the air window. When the puncture needle of the component II punctures the sealing plug in the air window of the component I, the second channel is communicated with the second injector through the puncture needle tube; when the component I and the component II are separated, the sealing plug in the air window can enable the air window to be in a sealing state and isolated from the outside.

Preferably, a through-stop module for controlling the through or the cut-off of the second channel is arranged in the second channel of the first needle seat so as to further ensure the tightness of the second channel relative to the outside. As one embodiment, the through-stop module is a rotatable through-stop valve, and a through hole is arranged in the valve; the through-stop valve enables the through hole to be aligned or misplaced with the second channel through rotation, and through or separation of the channels on two sides can be conveniently realized. As another embodiment, the stop module is a control valve, the control valve comprises a sliding block and a sliding groove, the sliding groove is arranged on the first needle seat in a penetrating way and penetrates through the second channel in the radial direction, the sliding block is slidably arranged in the sliding groove, and a through hole is arranged in the sliding block; when the sliding block slides to a preset position, two ends of the through hole are respectively butted with the second channel, and when the sliding block slides to a position outside the preset position, the outer side face of the sliding block cuts off the second channel.

As a preferred embodiment, the first hub is radially provided with a projection on the side adjacent to the second channel, and the louver is provided at the end of the projection. Further preferably, the length of the boss exceeds the radius of the first syringe barrel.

The sealing plug is made of an elastic material, preferably any one of rubber, silica gel and synthetic gel. Suitable elastic materials should meet the relevant criteria for medical materials, as will be readily appreciated and ascertained by those skilled in the art.

The dispensing needle assembly comprises an infusion channel and an exhaust channel, wherein the infusion channel is communicated with the first channel, and the exhaust channel is communicated with the second channel.

As one implementation mode, the dispensing needle assembly consists of a first needle tube and a second needle tube which are arranged in parallel and are fixedly connected to the first needle seat in a mode of embedding the rear ends. The inner cavity of the first needle tube forms an infusion channel, and the rear port is communicated with the first channel; the inner cavity of the second needle tube forms an exhaust channel, and the rear port is communicated with the second channel. It is particularly preferred that the first needle cannula, the first passageway and the first syringe are coaxially arranged.

As another implementation mode, the dispensing needle component is of a double-layer columnar structure and is provided with an inner column channel and a side ring channel, wherein one of the channels is used as an infusion channel, and the other channel is used as an exhaust channel. Preferably, the dispensing needle assembly consists of an inner needle tube and an outer needle tube, the inner needle tube is arranged inside the outer needle tube in a penetrating way, both ends of the inner needle tube extend out of the outer needle tube, at the moment, an inner column channel consists of an inner cavity of the inner needle tube, and a side ring channel consists of a cavity between the outer needle tube and the inner needle tube. The inner needle tube and the outer needle tube can be mutually independent, can be integrally formed and are fixedly connected with each other, and when the inner needle tube and the outer needle tube are of the latter type, the front end of the outer needle tube is preferably in closed fixed connection with the side wall of the front end of the inner needle tube. Further preferably, the front end of the inner needle tube is provided with an inclined opening, or the front end of the inner needle tube is provided with a tip and a side opening; the front side wall of the outer needle tube is provided with a side opening. The design of the opening is not only beneficial for the dispensing needle to penetrate into the container, but also can reduce interference between the inner column channel and the side ring channel. As a specific embodiment, the dispensing needle assembly, the first channel and the first syringe of the double-layer columnar structure are coaxially arranged, an inner column channel formed by the inner cavity of the inner needle tube is used as an infusion channel, and a side ring channel formed by the cavity between the outer needle tube and the inner needle tube is used as an exhaust channel. In another specific embodiment, in the dispensing needle assembly with the double-layer columnar structure, an inner column channel formed by the inner cavity of the inner needle tube is used as an exhaust channel, and a side ring channel formed by a cavity between the outer needle tube and the inner needle tube is used as an infusion channel.

Preferably, the assembly I further comprises a needle sealing assembly comprising a first sleeve arranged coaxially with the first needle hub, a first obturator and a first elastic member; wherein:

the first sleeve is of a hollow cylindrical structure with front and rear openings and is sleeved at the front end of the first needle seat in an axially movable manner;

the first sealing piece is made of elastic materials and is fixedly arranged in the front end cylinder body of the first sleeve; a duct for the needle tube to pass through is arranged in the first sealing piece, and the inner diameter of the duct is smaller than the outer diameter of the needle tube;

the first elastic piece is arranged between the first sealing piece and the first needle seat and supports the needle seat, and the first elastic piece provides axial elastic support for the first sealing piece at the front end;

under the non-pressure state, the first elastic piece extends axially, the first sleeve shields the needle tube inside the sleeve, and under the elastic action of the elastic material, the front end part of the needle tube is tightly wrapped by the first sealing piece, and the front end passage openings of the infusion passage and the exhaust passage are sealed;

under the pressure state, the first elastic piece is axially compressed, and the front end part of the needle tube including the front end passage opening of the infusion passage and the exhaust passage can pass through the hole of the first sealing piece and penetrate out of the first sleeve.

The needle head sealing assembly is arranged, so that the function of preventing puncture can be exerted, the medicine liquid preparation and transferring processes can be ensured to be in a fully-sealed state, and the risk of leakage of the medicine liquid from the front end passage opening is avoided. Components having similar structure and function have been reported in applicant's prior patents, such as CN115607444B, which is incorporated herein in its entirety.

As a preferred embodiment of the present invention, the needle seal assembly comprises a first sleeve, a first closure member, a first resilient member and an inner sleeve coaxially arranged, wherein:

the front end part of the first sleeve is smaller in inner diameter, and a composite cylindrical structure formed by a first cylindrical section with smaller inner diameter and a second cylindrical section with larger inner diameter is formed;

the first sealing piece is designed to be of an inverted T-shaped structure in cross section, the front diameter corresponds to the inner diameter of the first barrel section, the rear diameter corresponds to the inner diameter of the second barrel section, and therefore the first sealing piece can fill at least part of the inner cavity of the second barrel section while completely filling the inner cavity of the first barrel section;

the inner diameter of the inner sleeve corresponds to the outer diameter of the first needle seat, the outer diameter of the inner sleeve corresponds to the inner diameter of the second barrel section of the first sleeve, the front end face of the inner sleeve is closed, and a through hole for the needle tube to pass through is arranged on the end face of the inner sleeve; the inner sleeve is fixedly connected in the second barrel section of the first sleeve, and the front end face of the inner sleeve is abutted against the rear end face of the first sealing piece;

The first elastic piece is arranged in the inner sleeve, and two ends of the first elastic piece are respectively abutted against the inner surface of the front end of the inner sleeve and the front end face of the first needle seat.

Through improving the structure of first sleeve and first airtight piece and add the inner skleeve, first airtight piece is spacing fixed, and both ends all butt hard material around the first elastic component, and overall structure and performance are more stable. Further preferably, the outer wall of the inner sleeve is provided with a buckle, the second barrel section of the first sleeve is provided with a corresponding clamping hole, and the fixed connection between the first sleeve and the inner sleeve is realized through the cooperation of the buckle and the clamping hole when the inner sleeve is inserted into the first sleeve. Preferably, the rear end port of the inner sleeve is provided with an annular boss in a radially outward manner, and when the front end surface of the inner sleeve abuts against the rear end surface of the first sealing member, the annular boss at the rear end is exposed out of the first sleeve and abuts against the rear end of the first sleeve.

It will be readily appreciated that during use of the medical fluid transfer device of the present invention, the needle seal assembly remains attached to the first hub despite axial movement of the needle seal assembly in response to retraction of the first resilient member. As a preferred embodiment, both the front end inner surface of the inner sleeve and the front end surface of the first needle mount are provided with snap-fit structures, whereby a fixed connection with the first elastic member is achieved. As a further preferred embodiment, the side surface of the first needle seat is provided with an L-shaped groove consisting of an axial groove and a transverse groove (perpendicular to the axial groove), and the rear end of the inner sleeve is provided radially inwards with a sliding table which is embedded in the L-shaped groove and can slide along the groove. Through the position design of slip table and L shape recess, can nimble adjustment and restriction syringe needle seal assembly for the range of motion of first needle file. Along with the slip table backward slip along axial groove, first elastic component is compressed, the needle tubing wears out first airtight piece, rotates the slip table along horizontal groove after reaching the degree of setting, alright restriction syringe needle seal assembly's axial motion to reach spacing fixed effect.

The first closure member is made of an elastic material, preferably any one of rubber, silicone rubber, and synthetic rubber. Suitable elastic materials should meet the relevant criteria for medical materials, as will be readily appreciated and ascertained by those skilled in the art. In a preferred embodiment, the front end surface of the first sealing member protrudes beyond the front end surface of the first sleeve, so that the sealing member made of an elastic material can be attached to the glue port of the container during preparation and transfer of the liquid medicine, and the sealing member can better seal the opening of the container.

The first elastic member may be an elastically folded tube, a spring, or the like, preferably a spring.

It is easy to understand that for better connection with infusion tubes, drug vials, bolus devices, etc., the front end of the first sleeve is preferably provided with a fixed connection structure (e.g. a rotating snap structure, etc.) adapted to the pipetting connector for a fixed connection with the connector. The pipetting connectors are easily understood by those skilled in the art, and a large number of similar structures have been reported in the prior art, and the function of the pipetting connectors is mainly to realize auxiliary fixed connection between a liquid medicine transfer device and a liquid inlet of a transfusion tube interface, a bottle mouth or other equipment; preferably, the pipetting connector is provided with a closure (e.g. a rubber plug) at one end corresponding to the drug solution transfer device, which closure is pierceable by a needle tube, in order to better perform the closing function during infusion or drug solution transfer.

The component II comprises a second syringe, a second needle seat and a puncture needle fixedly connected to the second needle seat. And in the fixed connection state of the component I and the component II, the puncture needle of the component II pierces the sealing plug in the air window of the component I and is communicated with the second channel in the first needle seat.

It will be readily appreciated that the structural arrangement of the second hub and the needle in assembly II should correspond to the structural arrangement of the louver in assembly I. Preferably, when the first needle seat is radially provided with a protruding part at one side close to the second channel, and the louver is arranged at the tail end of the protruding part, the second needle seat and the puncture needle in the assembly II are arranged in a mode perpendicular to the second injection cylinder, and when the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction mode, the puncture needle transversely punctures the sealing plug to be communicated with the second channel in the first needle seat.

In order to achieve better system tightness, preferably, the assembly II further comprises a puncture needle sealing assembly comprising a second sleeve, a second closing element and a second elastic element arranged coaxially to the puncture needle; wherein,

the second sleeve is of a hollow cylindrical structure with an opening at the front end, and the rear end of the second sleeve is fixedly connected to the second needle seat;

The second sealing piece is made of elastic materials and is fixedly arranged in the front end cylinder body of the second sleeve; a pore canal for a puncture needle to pass through is arranged in the second sealing piece, and the inner diameter of the pore canal is smaller than the outer diameter of the puncture needle;

the second elastic piece is arranged between the second sealing piece and the second needle seat and supports the needle seat, and the second elastic piece provides axial elastic support for the second sealing piece at the front end;

under the non-pressure state, the second elastic piece axially stretches, the second sleeve shields the puncture needle inside the sleeve, and under the elastic action of the elastic material, the second sealing piece tightly wraps the front end part of the puncture needle to seal the puncture needle opening inside;

the second sealing member slides to the rear end under the pressed state, the second elastic member is axially compressed, and the front end of the puncture needle penetrates out of the second sealing member.

Further preferably, the lancet sealing assembly further comprises a sliding sleeve coaxially disposed with the lancet. The sliding sleeve is of a hollow cylindrical structure with front and rear openings, is arranged in the second sleeve, the outer diameter of the sliding sleeve is matched with the inner diameter of the second sleeve, the sliding sleeve can slide in the second sleeve along the axial direction, and the second sealing piece is filled in the sliding sleeve. More preferably, the sliding sleeve is designed into a composite cylindrical structure consisting of a front cylinder section with a larger inner diameter and a rear cylinder section with a smaller inner diameter; accordingly, the second sealing piece is designed to be of a T-shaped structure in cross section, so that the second sealing piece can completely fill the inner cavity of the sliding sleeve.

In order to prevent the second closing element or the sliding sleeve filled with the second closing element from moving outside the second sleeve, a limiting structure, such as a radially inward boss or the like, is preferably provided at the front end of the second sleeve.

The second closure is made of an elastic material, preferably any one of rubber, silicone, synthetic rubber. Suitable elastic materials should meet the relevant criteria for medical materials, as will be readily appreciated and ascertained by those skilled in the art. The second elastic member may be an elastically folded tube, a spring, or the like, preferably a spring.

As a preferred embodiment of the liquid medicine transfer device, the first needle seat in the component I is radially provided with a protruding part at one side close to the second channel, and the louver is arranged at the tail end of the protruding part; the second needle seat, the puncture needle and the puncture needle sealing component in the component II are arranged in a mode of being perpendicular to the second injection cylinder; when the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction mode, the air window with the sealing plug arranged therein is inserted into the second sleeve and pushes the second sealing piece or the sliding sleeve filled with the second sealing piece to slide towards the rear end, the second elastic piece is axially compressed, and the front end part of the puncture needle penetrates out of the second sealing piece and pierces the sealing plug to be communicated with the second channel in the first needle seat. Further preferably, the front end of the second sleeve is provided with a fixed buckle structure, and the protruding part of the first needle seat is provided with a fixed clamping groove matched with the fixed buckle structure; when subassembly I and subassembly II fixed connection, fixed buckle structure and fixed draw-in groove are fixed each other.

The liquid medicine transfer device has the characteristic of double-chamber circulation, and after the component I and the component II are fixedly and hermetically connected, the infusion channel, the first channel, the cavity of the first needle seat and the first injection cylinder are sequentially communicated from front to back to form a sealed passage I; the exhaust channel, the second channel, the puncture needle tube and the second injection tube are sequentially communicated from front to back to form a closed passage II. The two closed passages I and II are mutually independent, and the closed passage I is used for conveying the liquid medicine in the preparation and transfer processes of the liquid medicine, and the closed passage II plays roles of conveying gas and balancing air pressure. The liquid medicine transfer device can be used for the purposes of preparing mixed medicines, transferring the prepared liquid medicine into an infusion bottle, a retention needle or a push injection device and the like. With a full understanding of the construction of the above-described medical fluid transfer device of the present invention, it will be readily apparent to those skilled in the art how to use it for the preparation and transfer of medical fluid, for example, see applicant's prior patent CN115607444B, which is incorporated herein in its entirety.

Correspondingly, the invention also relates to the application of the liquid medicine transfer device in quantitative transfusion; and a quantitative transfusion device comprising the liquid medicine transfer device.

It is easily understood that the liquid medicine transferor of the present invention has the following excellent effects as well, like the closed liquid medicine transferor of the double-chamber circulation in CN 115607444B: (1) The structural design is exquisite, and each part is the component of being convenient for batch production and equipment, need not to use the component that the structure is relatively complicated, need not to use specific equipment. (2) The product has stable structure and performance, low cost, high yield and convenient use. (3) In the process of preparing and transferring the medicine, the internal and external air pressures of the medicine liquid transferring system are completely balanced. (4) The preparation and transfer of the totally-enclosed medicine can be realized, the risk of medicine leakage is reduced to the maximum extent, and the sealing effect is excellent.

Not only this, the invention can also solve the problem that the novel double-chamber type medicine dispenser can not be applied to the existing injection equipment, and the biggest improvement is that: the liquid medicine transfer device is designed to be split, a user can conveniently separate the component I from the component II after preparing liquid medicine (the liquid medicine is positioned in the first injection cylinder), at the moment, the sealing plug seals the second channel again, and the component I can be conveniently installed on the push injection device for quantitative liquid medicine transmission.

Drawings

FIG. 1 is a schematic sectional view showing the structure of a drug solution transfer device of example 1 in a split state;

FIG. 2 is a schematic sectional view showing the structure of the drug solution shifter of example 1 in an assembled state;

FIG. 3 is a schematic sectional view showing the construction of the drug solution shifter of example 2 in an assembled state;

FIG. 4 is a schematic view showing the use state of the component I of the drug solution transferor of example 2 connected with a chemical pump;

FIG. 5 is a schematic sectional view showing the structure of the drug solution transporter in an assembled state of embodiment 3;

FIG. 6 is a representative physical diagram of a drug solution shifter;

FIG. 7 is a schematic view showing the use of the component I in the drug solution transporter in example 3 on a single-channel quantitative injector;

fig. 8 is a schematic sectional view of the drug solution transporter of example 4 in a split state.

Reference numerals: the first syringe 1, the first syringe barrel 11, the first piston rod 12, the connector 13, the first needle holder 2, the first channel 21, the second channel 22, the boss 23, the louver 24, the sealing plug 25, the stop valve 26, the fixing clip groove 27, the cavity 28, the dispensing needle assembly 3, the first needle tube 31, the second needle tube 32, the second syringe 4, the second syringe barrel 41, the second piston rod 42, the buckle structure 43, the support 44, the second needle holder 5, the puncture needle 6, the puncture needle sealing assembly 7, the second sleeve 71, the sliding sleeve 72, the second sealing member 73, the second elastic member 74, the fixing buckle structure 75, the needle sealing assembly 8, the first sleeve 81, the first sealing member 82, the inner sleeve 83, the first elastic member 84, the pipetting connector 9, the chemical pump 10, and the capsule 101.

Detailed Description

For a better illustration of the objects, technical solutions and advantages of the present invention, the following detailed description of the present invention will be given with reference to the accompanying drawings and examples. The following examples are illustrative of the invention and are not intended to limit the scope of the invention.

Example 1

As shown in fig. 1, the split type double-chamber air pressure balanced liquid medicine transfer device comprises a component I and a component II. The liquid medicine transfer device is in a split state, and the components I and II are not fixedly connected.

The assembly I is constituted by a first syringe 1, a first needle holder 2 and a dispensing needle assembly 3.

The first syringe 1 includes a first syringe barrel 11, a first piston rod 12 slidable back and forth along the inner cavity in the first syringe barrel 11, and a joint 13 provided at the front end.

The first needle seat 2 is provided with a first channel 21 and a second channel 22 inside, and a protruding part 23 is radially arranged at one side close to the second channel 22, the length of the protruding part 23 exceeds the radius of the first injection tube 11, and the tail end of the protruding part 23 is provided with a louver 24. The end of the first needle holder 2 is provided with a cavity 28 for connection fixation with the connector 13 on the first syringe 1. The end of the first channel 21 communicates with the cavity 28 and the end of the second channel 22 communicates with the louver 24. A sealing plug 25 made of elastic medical silica gel is fixedly arranged in the air window 24 in an interference mode, and the sealing plug 25 enables the air window 24 to be in a sealing state and isolated from the outside.

The first needle holder 2 is fixedly connected with the first syringe 1 by inserting the connector 13 on the first syringe 1 into the cavity 28 at the end of the first needle holder 2.

The dispensing needle assembly 3 consists of a first needle tube 31 and a second needle tube 32 which are arranged in parallel and are fixedly connected to the first needle seat 2 in a mode that the rear ends of the two needle tubes are embedded. The inner cavity of the first needle tube 31 forms an infusion channel, and the rear port is communicated with the first channel 21; the interior cavity of the second needle cannula 32 forms a vent passageway and the rear port communicates with the second passageway 22. The first needle tube 31, the first channel 21 and the first syringe 1 are coaxially arranged.

The assembly II comprises a second syringe 4, a second needle holder 5, a needle 6 fixedly attached to the second needle holder 5, and a needle seal assembly 7.

The second syringe 4 includes a second syringe 41 having the same size as the first syringe 11, and a second piston rod 42 slidable back and forth along the inner cavity in the second syringe 41. The supporting part 44 is arranged on the wall of the second injection tube 41, and the end structure of the supporting part 44 is matched with the outer side wall of the first injection tube 11, so that the first injection tube 11 and the second injection tube 41 are mutually supported by the supporting part 44 when being arranged side by side and in the same direction, and a better fixing effect is achieved. The outer wall of the end of the second syringe 41 is provided with a snap-fit structure 43 so that the first syringe 11 and the second syringe 41 are detachably fixed to each other when they are arranged side by side and in the same direction.

The structural arrangement of the second needle mount 5 and the puncture needle 6 corresponds to the structural arrangement of the louver 24 in the assembly I. Specifically, the second needle seat 5 and the puncture needle 6 are disposed perpendicular to the second syringe 41, and when the first syringe 11 and the second syringe 41 are fixedly connected in a side-by-side and co-directional manner, the puncture needle 6 can transversely pierce the sealing plug 25 to communicate with the second channel 22 in the first needle seat 2.

The needle seal assembly 7 comprises a second sleeve 71, a sliding sleeve 72, a second obturator 73 and a second elastic element 74 arranged coaxially with the needle 6.

The second sleeve 71 has a hollow cylindrical structure with an open front end, and a rear end is fixedly connected to the second needle holder 5.

The slide sleeve 72 is a hollow cylindrical structure with front and rear openings, and is designed as a composite cylindrical structure composed of a front cylindrical section with a larger inner diameter and a rear cylindrical section with a smaller inner diameter. The sliding sleeve 72 is disposed in the second sleeve 71, and has an outer diameter adapted to an inner diameter of the second sleeve 71, and is slidable axially back and forth in the second sleeve 71.

The second closure member 73 is made of elastic medical grade silicone and is designed to have a T-shaped cross-section, completely filling the interior cavity of the sliding sleeve 72. The second sealing member 73 is provided with a hole through which the puncture needle 6 passes, and the inner diameter of the hole is smaller than the outer diameter of the puncture needle 6.

The second elastic element 74 is a spring and is arranged between the sliding sleeve 72 and the second needle seat 5, and the second elastic element 74 provides axial elastic support for the sliding sleeve 72 at the front end by depending on the needle seat 5. As shown in fig. 1, in the non-compressed state, the second elastic member 74 is axially stretched, the second sleeve 71 shields the puncture needle 6 inside the sleeve, and the second sealing member 73 tightly wraps the front end portion of the puncture needle 6 under the elastic force of the elastic material, sealing the puncture needle opening inside.

In order to prevent the sliding sleeve 72 filled with the second sealing member 73 from moving outside the second sleeve 71, a radially inward boss is provided at the front end of the second sleeve 71 to achieve the limiting purpose. Meanwhile, the front end of the second sleeve 71 is provided with a fixing and fastening structure 75, the fixing and fastening structure 75 is adapted to the fixing and fastening groove 27 provided on the protruding portion 23 of the first needle holder 2, and when the component I and the component II are fixedly connected, the fixing and fastening structure 75 and the fixing and fastening groove 27 are fixedly connected with each other.

Fig. 2 shows the drug solution shifter in a state where the component I and the component II are fixedly connected. The first syringe 11 and the second syringe 41 are fixedly connected in a side-by-side and equidirectional manner, the louver 24 provided with the sealing plug 25 therein is inserted into the second sleeve 71 and pushes the sliding sleeve 72 filled with the second sealing member 73 to slide toward the rear end, the second elastic member 74 is axially compressed, and the front end portion of the puncture needle 6 penetrates the second sealing member 73 and pierces the sealing plug 25 to communicate with the second channel 22 in the first needle holder 2. At the same time, the fixing clip structure 75 is connected and fixed with the fixing clip groove 27.

As shown in fig. 2, after the component I and the component II are fixedly and hermetically connected, the infusion channel, the first channel 21, the cavity 28 of the first needle seat 2 and the first syringe 11 are sequentially communicated from front to back to form a sealed passage I; the vent passage, the second passage 22, the puncture needle tube and the second syringe 41 are sequentially communicated from front to back to form a closed passage II. The two closed passages I and II are mutually independent, and the closed passage I is used for conveying the liquid medicine in the preparation and transfer processes of the liquid medicine, and the closed passage II plays roles of conveying gas and balancing air pressure.

Example 2

FIG. 3 shows another embodiment of the split dual chamber pressure balanced medical fluid transfer device of the present invention. Compared with the liquid medicine transferer of example 1, the difference is mainly that: the assembly I further comprises a needle seal assembly 8.

The needle sealing assembly 8 comprises a first sleeve 81, a first obturator 82, an inner sleeve 83 and a first elastic member 84 arranged coaxially to the first needle mount 2.

The front end portion of the first sleeve 81 has a smaller inner diameter, and forms a composite tubular structure composed of a first tubular section having a smaller inner diameter and a second tubular section having a larger inner diameter. Two buckling structures are symmetrically arranged on the front-end extension surface of the first barrel section so as to be fixedly connected with the pipetting connector; the second barrel section is symmetrically provided with two clamping holes on the barrel wall adjacent to the rear port.

The first closure 82 is made of resilient medical grade silicone having an inverted T-shaped cross-section with a front diameter equal to the inner diameter of the first barrel section and a length slightly greater than the axial length of the first barrel section and a rear diameter equal to the inner diameter of the second barrel section. The first closing member 82 completely fills the first barrel section inner cavity and the second barrel section front end inner cavity while the front end surface protrudes beyond the front end surface of the first sleeve 81. The first sealing member 82 is provided with a hole through which the first needle tube 31 and the second needle tube 32 pass, and the hole has an inner diameter smaller than the outer diameter of the needle tube.

The inner diameter and the outer diameter of the inner sleeve 83 correspond to the outer diameter of the first needle seat 2 and the inner diameter of the second barrel section of the first sheath 81, respectively, the front end face thereof is closed and provided with a through hole for the first needle tube 31 and the second needle tube 32 to pass through, the rear port is provided with an annular boss in a radially outward manner, and two buckles matched with the clamping holes are symmetrically arranged on the outer wall adjacent to the rear port.

The inner sleeve 83 is inserted into the second barrel section of the first sheath 81, and fixed connection between the inner sleeve 83 and the second barrel section is achieved through matching of the buckle and the clamping hole, meanwhile, the front end face of the inner sleeve 83 is abutted against the rear end face of the first sealing piece 82, and the annular boss at the rear end is exposed out of the first sheath 81 and is abutted against the rear end of the first sheath 81.

The first elastic member 84 is a spring, and is disposed in the inner sleeve 83, and both ends thereof are respectively abutted against the inner surface of the front end of the inner sleeve 83 and the front end surface of the first needle holder 2.

The side face of the first needle holder 2 is symmetrically provided with two L-shaped grooves consisting of an axial groove and a transverse groove, and correspondingly, the rear end of the inner sleeve 83 is radially and inwardly symmetrically provided with two sliding tables which are embedded in the L-shaped grooves and can slide along the grooves.

As shown in fig. 3, in the non-pressurized state of the needle sealing assembly 8 of the assembly I, the first elastic member 84 extends axially, the sliding table of the inner sleeve 83 is located at the front end of the axial groove on the side surface of the first needle holder 2, the first sheath 81 shields the first needle tube 31 and the second needle tube 32 inside the first sheath 81, and under the elastic force of the silica gel, the first sealing member 82 tightly wraps the front end parts of the first needle tube 31 and the second needle tube 32, so that the front end passage openings of the infusion passage and the exhaust passage are sealed.

The medical fluid transfer device of the present invention is designed to be split such that a user can easily separate the components I and II after preparing the medical fluid (the medical fluid is in the first syringe 11), and the second passage 22 is sealed again by the sealing plug 25. The separate assembly I may be very conveniently docked with a pipetting connector for medical fluid transfer or mounted to a bolus device for metered medical fluid transfer.

The application of pipetting to a chemotherapeutic pump can be seen in fig. 4, comprising:

the first step is to fixedly connect the component I with one end (provided with a rubber plug) of the pipetting connector 9 by a buckle, and fixedly butt-connect the other end of the pipetting connector 9 to a transfusion tube interface of the chemical pump 10.

In the second step, the first syringe 1 is pushed forward, so that the front end portions of the first needle tube 31 and the second needle tube 32 including the front end passage openings of the infusion path and the exhaust path are passed out of the first sealing member 82, and are communicated with the inner cavity of the pipetting connector 9 after piercing the rubber stopper. The sliding table of the inner sleeve 83 slides backward synchronously along the axial groove, and moves into the transverse groove by rotating the first syringe 1 or the first sheath 81, so that the axial movement of the needle sealing assembly 8 is limited, and the effect of limiting and fixing is achieved.

Third, the first piston rod 12 is pushed to push the liquid medicine prepared in the first injection cylinder 11 into the chemotherapy pump 10 through the infusion channel, and the capsule body in the chemotherapy pump 10 is gradually expanded to increase the pressure. In this process, since the exhaust passage is blocked by the sealing plug 25, the high-pressure medical fluid does not leak from the exhaust passage.

Example 3

FIG. 5 shows yet another form of split dual chamber pressure balanced medical fluid transfer device of the present invention. Compared with the liquid medicine transferer of example 2, the difference is mainly that: a rotatable through-stop valve 26 for controlling the through or the blocking of the second channel 22 is arranged in the second channel 22 of the first needle seat 2, and a through hole is arranged in the valve. The through-stop valve 26 is rotated to align or misalign the through-hole with the second channel, so that the through-hole or the separation of the channels on both sides can be conveniently realized.

FIG. 6 is a schematic representation of a drug solution transfer device. In the drawings, fig. 6a is a sample plan in assembled state; FIG. 6b is a sample plan in a split state; fig. 6c is a sample view of various connectors.

Unlike existing dual-chamber drug fluid transfer devices, the drug fluid transfer device of the present invention can be conveniently adapted to existing bolus devices for quantitative drug fluid transfer. As shown in fig. 7, a method for use on a single channel quantitative bolus comprising the steps of:

in the first step, after the drug solution is prepared (the drug solution is in the first syringe 11), the component I and the component II are separated, and the through-valve 26 is rotated so that the inner through-hole thereof is offset from the second passage 22. At this time, the second passage 22 is sealed again by the sealing plug 25, and the second passage 22 is blocked by the check valve 26, and the double safety ensures the tightness of the exhaust passage.

And secondly, fixedly connecting the component I with one end (provided with a rubber plug) of the pipetting connector 9 through a buckle, and fixedly butt-connecting the other end of the pipetting connector 9 to an infusion tube interface.

Third, the first syringe 1 is pushed forward, so that the front end portions of the first needle tube 31 and the second needle tube 32 including the front end passage openings of the infusion path and the exhaust path pass out of the first sealing member 82, and communicate with the inner cavity of the pipetting connector 9 after piercing the rubber stopper. The sliding table of the inner sleeve 83 slides backward synchronously along the axial groove, and moves into the transverse groove by rotating the first syringe 1 or the first sheath 81, so that the axial movement of the needle sealing assembly 8 is limited, and the effect of limiting and fixing is achieved.

Fourth, the fixing hook on the quantitative injector is pulled to fix the first injection cylinder 11 on the quantitative injector, the tail end neck of the first piston rod 12 is mounted on the fixing clamp, and the liquid pushing end is abutted against the rear end face of the first piston rod 12.

Fifth, an infusion program is set, and the first piston rod 12 is pushed at a preset speed, so that the liquid medicine in the first injection cylinder 11 is quantitatively delivered into the infusion tube.

In the above application, the connection between the component I and the dosing injector does not leak. The first syringe 11 can be stably mounted to the quantitative injector without occupying a space of the quantitative injector.

It will be readily appreciated that the medical fluid transfer device of the present invention is equally applicable to dual or more channel metered dose infusers.

Example 4

FIG. 8 shows yet another form of split dual chamber pressure balanced medical fluid transfer device of the present invention. Compared with the liquid medicine transferer of example 3, the difference is mainly that: the dispensing needle assembly 3 is of a double-layer columnar structure and consists of an inner needle tube and an outer needle tube which are integrally formed and fixedly connected with each other, the inner needle tube is arranged inside the outer needle tube in a penetrating mode, and two ends of the inner needle tube extend out of the outer needle tube. At this time, an inner column passage formed by the inner cavity of the inner needle tube is used as an exhaust passage, and a side ring passage formed by the cavity between the outer needle tube and the inner needle tube is used as an infusion passage. The front end of the inner needle tube is a tip and is provided with a side opening, and the side wall of the front end of the outer needle tube is provided with a side opening.

The foregoing embodiments have described primarily the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the foregoing embodiments, which have been described in the foregoing description merely illustrates the principles of the invention, and that various changes and modifications may be made therein without departing from the spirit and scope of the invention, which is defined in the appended claims.

Claims

1. A split type double-chamber air pressure balanced liquid medicine transfer device, comprising a component I and a component II, wherein:

2. The medical fluid transfer device of claim 1, wherein: the first injector comprises a first injection cylinder and a first piston rod which can slide back and forth along the inner cavity in the first injection cylinder; the second injector comprises a second injection cylinder and a second piston rod which can slide back and forth along the inner cavity in the second injection cylinder;

preferably, in the fixedly connected state of the component I and the component II, the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction mode;

further preferably, a fastening structure is arranged on the outer wall of at least one of the first injection cylinder and the second injection cylinder, so that the first injection cylinder and the second injection cylinder are detachably fixed with each other when being arranged side by side and in the same direction; and/or at least one of the first injection cylinder and the second injection cylinder is provided with a supporting part on the cylinder wall, and the end structure of the supporting part is matched with the outer side wall of the opposite injection cylinder, so that the first injection cylinder and the second injection cylinder are mutually supported by the supporting part when being arranged side by side and in the same direction.

3. The medical fluid transfer device of claim 1, wherein: a through-stop module for controlling the second passage to be communicated or cut off is arranged in the second passage of the first needle seat;

preferably, the through-stop module is a rotatable through-stop valve, and a through hole is arranged in the valve; the through-stop valve enables the through hole and the second channel to be aligned or misplaced through rotation, so that the through or separation of the channels on two sides is realized; or,

the stop module is a control valve, the control valve comprises a sliding block and a sliding groove which is arranged on the first needle seat in a penetrating way and penetrates through the second channel from the radial direction, the sliding block is slidably arranged in the sliding groove, and a through hole is arranged in the sliding block; when the sliding block slides to a preset position, two ends of the through hole are respectively butted with the second channel, and when the sliding block slides to a position outside the preset position, the outer side face of the sliding block cuts off the second channel.

4. The medical fluid transfer device of claim 1, wherein: the first needle seat is radially provided with a protruding part at one side close to the second channel, and the louver is arranged at the tail end of the protruding part; preferably, the length of the boss exceeds the radius of the first syringe barrel.

5. The medical fluid transfer device of claim 1, wherein: the dispensing needle assembly consists of a first needle tube and a second needle tube which are arranged in parallel and are fixedly connected to the first needle seat in a mode that the rear ends of the first needle tube and the second needle tube are embedded;

Wherein the inner cavity of the first needle tube forms an infusion channel, and the rear port is communicated with the first channel; the inner cavity of the second needle tube forms an exhaust channel, and the rear port is communicated with the second channel.

6. The medical fluid transfer device of claim 1, wherein: the dispensing needle component is of a double-layer columnar structure and is provided with an inner column channel and a side ring channel, wherein one of the channels is used as an infusion channel, and the other channel is used as an exhaust channel;

preferably, the dispensing needle assembly consists of an inner needle tube and an outer needle tube, the inner needle tube is arranged inside the outer needle tube in a penetrating way, both ends of the inner needle tube extend out of the outer needle tube, at the moment, an inner column channel consists of an inner cavity of the inner needle tube, and a side ring channel consists of a cavity between the outer needle tube and the inner needle tube.

7. The medical fluid transfer device of claim 1, wherein: assembly I further comprises a needle seal assembly comprising a first sleeve coaxially disposed with the first hub, a first closure member and a first resilient member; wherein,

8. The medical fluid transfer set according to claim 7, wherein: the needle seal assembly comprises a first sleeve, a first sealing member, a first elastic member and an inner sleeve which are coaxially arranged, wherein:

9. The medical fluid transfer set according to claim 8, wherein:

the outer wall of the inner sleeve is provided with a buckle, the second barrel section of the first sleeve is provided with a corresponding clamping hole, and when the inner sleeve is inserted into the first sleeve, the fixed connection between the first sleeve and the inner sleeve is realized through the matching of the buckle and the clamping hole;

preferably, the rear end port of the inner sleeve is provided with an annular boss in a radially outward manner, and when the front end surface of the inner sleeve abuts against the rear end surface of the first sealing member, the annular boss at the rear end is exposed out of the first sleeve and abuts against the rear end of the first sleeve.

10. The medical fluid transfer set according to claim 8, wherein: the inner surface of the front end of the inner sleeve and the front end face of the first needle seat are both provided with buckling structures, so that the fixed connection with the first elastic piece is realized.

11. The medical fluid transfer set according to claim 8, wherein: the side of the first needle seat is provided with an L-shaped groove formed by an axial groove and a transverse groove, the rear end of the inner sleeve is radially inwards provided with a sliding table, and the sliding table is embedded into the L-shaped groove and can slide along the groove.

12. The medical fluid transfer device according to claim 7 or 8, wherein: the front end face of the first sealing piece protrudes out of the front end face of the first sleeve.

13. The medical fluid transfer device according to claim 7 or 8, wherein: the front end of the first sleeve is provided with a fixed connection structure matched with the connector so as to be fixedly connected with the connector.

14. The medical fluid transfer set forth in claim 4, wherein: the second needle seat and the puncture needle in the component II are arranged in a mode of being perpendicular to the second injection tube, and when the first injection tube and the second injection tube are fixedly connected in a side-by-side and same-direction mode, the puncture needle transversely pierces the sealing plug and is communicated with the second channel in the first needle seat.

15. The medical fluid transfer device of claim 1, wherein: the assembly II further comprises a puncture needle sealing assembly, wherein the puncture needle sealing assembly comprises a second sleeve, a second sealing piece and a second elastic piece, and the second sleeve, the second sealing piece and the second elastic piece are coaxially arranged with the puncture needle; wherein,

16. The medical fluid transfer set of claim 15, wherein: the puncture needle sealing assembly further comprises a sliding sleeve coaxially arranged with the puncture needle; the sliding sleeve is of a hollow cylindrical structure with front and rear openings, is arranged in the second sleeve, the outer diameter of the sliding sleeve is matched with the inner diameter of the second sleeve, the sliding sleeve can slide in the second sleeve along the axial direction, and the second sealing piece is filled in the sliding sleeve;

Preferably, the sliding sleeve is designed into a composite cylindrical structure consisting of a front cylinder section with a larger inner diameter and a rear cylinder section with a smaller inner diameter; accordingly, the second sealing piece is designed to be of a T-shaped structure in cross section, so that the second sealing piece can completely fill the inner cavity of the sliding sleeve.

17. The medical fluid transfer device according to claim 15 or 16, wherein: the first needle seat in the component I is radially provided with a protruding part at one side close to the second channel, and the transom is arranged at the tail end of the protruding part; the second needle seat, the puncture needle and the puncture needle sealing component in the component II are arranged in a mode of being perpendicular to the second injection cylinder; when the first injection cylinder and the second injection cylinder are fixedly connected in a side-by-side and same-direction mode, the air window with the sealing plug arranged therein is inserted into the second sleeve and pushes the second sealing piece or the sliding sleeve filled with the second sealing piece to slide towards the rear end, the second elastic piece is axially compressed, and the front end part of the puncture needle penetrates out of the second sealing piece and pierces the sealing plug to be communicated with the second channel in the first needle seat.

18. The medical fluid transfer device according to claim 15 or 16, wherein: the front end of the second sleeve is provided with a fixed buckle structure, and the protruding part of the first needle seat is provided with a fixed clamping groove matched with the fixed buckle structure; when subassembly I and subassembly II fixed connection, fixed buckle structure and fixed draw-in groove are fixed each other.

19. Use of the medical fluid transfer device of any one of claims 1-18 for quantitative infusion.

20. A metered dose infusion device comprising the fluid transfer device of any one of claims 1-18.