CN117054176A - Glucose solution preparation equipment - Google Patents

Glucose solution preparation equipment Download PDF

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Publication number
CN117054176A
CN117054176A CN202210489891.6A CN202210489891A CN117054176A CN 117054176 A CN117054176 A CN 117054176A CN 202210489891 A CN202210489891 A CN 202210489891A CN 117054176 A CN117054176 A CN 117054176A
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China
Prior art keywords
solution
tank
solution tank
glucose
pbs
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CN202210489891.6A
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Chinese (zh)
Inventor
王顺兵
陈志敏
陈鹏宇
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Shenzhen Guiji Sensing Technology Co ltd
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Shenzhen Guiji Sensing Technology Co ltd
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Priority to CN202210489891.6A priority Critical patent/CN117054176A/en
Publication of CN117054176A publication Critical patent/CN117054176A/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416Systems
    • G01N27/4163Systems checking the operation of, or calibrating, the measuring apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N2001/2893Preparing calibration standards

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

The disclosure describes a glucose solution preparation device, which is characterized by comprising a liquid storage tank, a first solution tank, a first measurement module arranged on the first solution tank, a second measurement module arranged on the second solution tank and a control module, wherein the liquid storage tank stores ultrapure water and conveys the ultrapure water to the first solution tank, the first solution tank utilizes the ultrapure water to prepare PBS solution and conveys the PBS solution to the second solution tank, the first measurement module measures the quantity of the solution of the first solution tank, the second solution tank utilizes the PBS solution to prepare glucose solution with target concentration, the second measurement module measures the quantity of the PBS solution of the second solution tank, the control module controls the liquid storage tank to convey the ultrapure water to the first solution tank and controls the conveying speed of the ultrapure water, and the control module controls the first solution tank to convey the PBS solution to the second solution tank and controls the conveying speed of the PBS solution. In this case, the glucose solution preparing apparatus can rapidly and accurately prepare the PBS solution and the glucose solution of the target concentration.

Description

Glucose solution preparation equipment
Technical Field
The present disclosure relates to the field of biomedical industry, and in particular, to a glucose solution preparing apparatus.
Background
Diabetes is a chronic life-long disease, and the treatment of diabetes is a comprehensive treatment which comprises diet, exercise, drug treatment, blood sugar detection and education for patients; wherein blood glucose self-monitoring is an important measure for guiding blood glucose control to reach standards.
The continuous blood glucose monitoring product is used for monitoring the glucose concentration in human blood glucose, can monitor the blood glucose condition of diabetics in real time, and needs to use a sensing electrode in the production process, the sensing electrode tests and corrects glucose solutions with different concentrations, and the glucose solutions with different concentrations are required to test, so that the tested glucose solutions cannot be reused, and a large amount of glucose solutions with different concentrations are required in the production process.
The existing glucose solution preparation is calculated according to the weight of glucose solute and the weight of ultrapure water, the relevant glucose solute is dissolved in the ultrapure water and then added into the ultrapure water with a certain volume for dissolution proportioning and stirring, if the glucose solution inventory with a certain concentration in the production process is used up, a long time is required for manual reconstitution or purchase, the speed of the traditional manual glucose solution preparation is slower, the cost is higher, and the efficiency of testing and correcting the sensing electrode in the sensing electrode electrochemical automation equipment is affected by preparing a new glucose solution or purchasing a new glucose solution.
Disclosure of Invention
The present disclosure has been made in view of the above-mentioned prior art, and an object thereof is to provide an apparatus capable of preparing glucose solutions of different concentrations, and to provide a method for preparing glucose solutions and PBS solutions of different target concentrations conveniently and rapidly.
The glucose solution preparation device is characterized by comprising a liquid storage tank, a first solution tank, a first measuring module, a second solution tank, a second measuring module and a control module, wherein the first measuring module is arranged on the first solution tank, the second measuring module is arranged on the second solution tank, the liquid storage tank is configured to store ultrapure water and deliver the ultrapure water to the first solution tank, the first solution tank is configured to prepare PBS solution by using the ultrapure water and deliver the PBS solution to the second solution tank, the first measuring module is configured to measure the solution quantity of the first solution tank, the second solution tank is configured to prepare glucose solution with a target concentration by using the PBS solution, the second measuring module is configured to measure the solution quantity of the second solution tank, the control module is configured to control the ultrapure water to be delivered to the first solution tank, and control the ultrapure water delivery speed based on the measured value of the first measuring module, and control the PBS solution delivery speed based on the measured value of the second measuring module. Thus, the first solution tank can rapidly and accurately prepare the PBS solution, and the second solution tank can rapidly and accurately prepare the glucose solution of the target concentration.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the glucose solution preparation apparatus is connected to an ultrapure water production apparatus, and the liquid storage tank is connected to the ultrapure water production apparatus through a pipe. Thus, the external ultrapure water producing apparatus can supply ultrapure water in real time to the liquid tank of the glucose solution preparing apparatus.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the first measurement module includes a first weighing apparatus disposed at a bottom of the first solution tank, the first weighing apparatus being configured to measure a weight of the solution transferred to the first solution tank. Thereby, the solution in the first solution tank can be weighed in real time.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the glucose solution preparing apparatus further includes a first solution tank holder for supporting the first solution tank and a second solution tank holder for supporting the second solution tank. Thus, the first solution tank support can support the first solution tank away from the first weighing device, and the second solution tank support can support the second solution tank away from the second weighing device.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the first solution tank holder is provided with a first clamping mechanism, the second solution tank holder is provided with a second clamping mechanism, the first clamping mechanism is configured to clamp the first solution tank to disengage the first solution tank from the first weighing apparatus, and the second clamping mechanism is configured to clamp the second solution tank to disengage the second solution tank from the second weighing apparatus. Therefore, the first solution tank can be separated from the first weighing equipment during solution stirring, and the second solution tank can be separated from the second weighing equipment during solution stirring, so that the impact of solution stirring on the weighing equipment is reduced.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the first solution tank further includes a first stirring device configured to stir the solution in the first solution tank after the first solution tank is separated from the first weighing apparatus, and the second solution tank further includes a second stirring device configured to stir the solution in the second solution tank after the second solution tank is separated from the second weighing apparatus. In this case, the first stirring device stirs the first solution tank solution after the first solution tank is separated from the first weighing apparatus, thereby reducing shaking impact on the first weighing apparatus when the first stirring device stirs the solution in the first solution tank; the second stirring device is used for stirring the solution in the second solution tank after the second solution tank is separated from the second weighing equipment, so that shaking impact on the second weighing equipment caused by the stirring of the solution in the second solution tank by the second stirring device is reduced.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the first measurement module includes a first liquid level sensor disposed inside the first solution tank, the first liquid level sensor being configured to measure a liquid level of the solution in the first solution tank. Thereby, the level of the solution of the first solution tank can be measured by the first level sensor.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the first measurement module includes a PH sensor disposed inside the first solution tank, the PH sensor being configured to measure a PH value of the solution in the first solution tank. In this case, the pH of the PBS solution of the first solution tank can be measured in real time.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the second measuring module includes a second liquid level sensor disposed inside the second solution tank, the second liquid level sensor being configured to measure a liquid level of the solution in the second solution tank. Thereby, the level of the solution of the second solution tank can be measured by the second level sensor.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the second measurement module includes an analyzer disposed inside the second solution tank, the analyzer configured to measure a concentration of the glucose solution in the second solution tank. Thereby, the concentration of the stirred formulated glucose solution can be measured by the second measurement module and it is determined by the analyzer whether the concentration of the formulated glucose solution is within the target concentration range.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the concentration of the glucose solution prepared in the second solution tank is 2.2mmol/L, 5mmol/L, 10mmol/L, 15mmol/L, 20mmol/L, and 25mmol/L, respectively. Thus, the second solution tank can prepare 2.2mmol/L, 5mmol/L, 10mmol/L, 15mmol/L, 20mmol/L, and 25mmol/L respectively and deliver to the electrochemical automated testing equipment of the sensing electrode.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the liquid storage tank includes a liquid storage tank liquid pump that pumps ultrapure water in the liquid storage tank into the first solution tank, and a liquid storage tank peristaltic pump that pumps ultrapure water in the liquid storage tank into the first solution tank. In this case, the tank suction pump can pump the tank ultrapure water and add it to the first solution tank at different delivery rates, thereby controlling the amount of ultrapure water added to the first solution tank more accurately.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the control module starts and stops a liquid tank pump or a liquid tank peristaltic pump in the liquid tank based on the measurement value of the first measurement module. Therefore, the automatic control of the start and stop of the pumping of the ultrapure water by the liquid storage tank liquid pump and the pumping of the ultrapure water by the peristaltic pump can be realized.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the first solution tank includes a first solution tank pump and a first solution tank peristaltic pump, the first solution tank pump pumps the PBS solution in the first solution tank into the second solution tank, and the first solution tank peristaltic pump pumps the PBS solution in the first solution tank to be added precisely into the second solution tank. In this case, the peristaltic pump of the first solution tank can pump the PBS solution in the first solution tank and feed the PBS solution into the second solution tank at different delivery rates, thereby more precisely controlling the amount of PBS solution added to the second solution tank.
Additionally, in the glucose solution preparation apparatus related to the present disclosure, optionally, the control module starts and stops the first solution tank liquid pump or the first solution tank peristaltic pump in the first solution tank based on the measurement value of the second measurement module. Therefore, the automatic control of the start and stop of the pumping of the PBS solution by the first solution tank liquid pump and the pumping of the PBS solution by the first solution tank peristaltic pump can be realized.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the first solution tank further includes a first stirring device configured to stir the solution in the first solution tank after the liquid storage tank stops delivering the ultrapure water, and the second solution tank further includes a second stirring device configured to stir the solution in the second solution tank after the first solution tank stops delivering the PBS solution. In this case, the first stirring device stirs the PBS solution in the first solution tank, enabling the PBS solution in the first solution tank to be sufficiently mixed; the second stirring device stirs the glucose solution in the second solution tank, so that the glucose solution in the second solution tank can be fully mixed and the glucose solution at each position can reach the same concentration.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the glucose solution preparation apparatus further includes a first cleaning device disposed on the first solution tank, the first cleaning device being configured to clean the first solution tank before the PBS solution is prepared. In this case, the first cleaning device cleans the first solution tank to keep the first solution tank clean.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, a plurality of concentrations of glucose solutions are prepared by the glucose solution preparation apparatus, and the second solution tank is cleaned between preparing glucose solutions of different concentrations. In this case, the second solution tank can be kept clean, so that accurate preparation of glucose solutions of the respective target concentrations can be facilitated.
In addition, in the glucose solution preparation apparatus according to the present disclosure, optionally, the glucose solution preparation apparatus further includes a second cleaning device provided to the second solution tank, the second cleaning device being configured to clean the second solution tank before the glucose solution of the target concentration is prepared or after the glucose solution of the target concentration is prepared. Therefore, the second cleaning device can clean the second solution tank before or after preparing the glucose solution with the target concentration, and the second solution tank can be kept clean, so that the glucose solution with the corresponding target concentration can be accurately prepared.
In addition, in the glucose solution preparing apparatus according to the present disclosure, optionally, the glucose solution preparing apparatus further includes a display module that displays an operation condition of the glucose solution preparing apparatus and switches an automatic operation mode or a manual control mode of the glucose solution preparing apparatus by a manual input. Thus, the operator can control the glucose solution preparing apparatus in real time by an automatic working mode or a manual control mode.
In addition, in the glucose solution preparation device related to the present disclosure, optionally, the glucose solution preparation device is connected to a sensing electrode electrochemical automation test device, the control module is configured to deliver a portion of the PBS solution to the sensing electrode electrochemical automation test device after the PBS solution of the first solution tank is prepared, and the control module is configured to deliver to the sensing electrode electrochemical automation test device after the glucose solution of the target concentration of the second solution tank is prepared. Thus, the glucose solution preparation device can provide PBS solution to the sensing electrode electrochemical automatic test device, and the glucose solution preparation device can also provide glucose solutions with various concentrations to the sensing electrode electrochemical automatic test device.
According to the present invention, there is provided a glucose solution preparing apparatus capable of rapidly and accurately preparing a PBS solution and capable of rapidly and accurately preparing glucose solutions of various target concentrations.
Drawings
Fig. 1 is a schematic diagram showing the structure of a glucose solution preparing apparatus according to an example of the present embodiment.
Fig. 2 is a schematic diagram showing the structure of the whole connection of the liquid storage tank, the first solution tank, and the second solution tank according to the example of the present embodiment.
Fig. 3 is a schematic diagram showing a structure of a liquid storage tank according to an example of the present embodiment.
Fig. 4 is a schematic diagram showing the configuration of the first solution tank and the first weighing apparatus according to the example of the present embodiment.
Fig. 5 shows a schematic structural view of a second solution tank and a second weighing apparatus according to an example of the present embodiment.
Fig. 6 shows a flowchart of a PBS solution formulation method according to an example of this embodiment.
Fig. 7 is a flowchart showing a glucose solution preparation method according to an example of the present embodiment.
Reference numerals illustrate:
1 … … glucose solution preparation equipment
10 … …,101 … …,102 … …,
11 … … first solution tank, 111 … … first weighing device, 113 … … first solution tank holder, 114 … … first clamping mechanism, 115 … … first stirring device, 117 … … first solution tank pump, 118 … … first solution tank peristaltic pump,
12 … … second solution tank, 121 … … second weighing apparatus, 123 … … second solution tank holder, 124 … … second clamping mechanism, 125 … … second stirring device,
13 … … control module, 14 … … display module.
Detailed Description
Hereinafter, preferred embodiments of the present disclosure will be described in detail with reference to the accompanying drawings. In the following description, the same members are denoted by the same reference numerals, and overlapping description thereof is omitted. In addition, the drawings are schematic, and the ratio of the sizes of the components to each other, the shapes of the components, and the like may be different from actual ones.
In addition, headings and the like referred to in the following description of the disclosure are not intended to limit the disclosure or scope thereof, but rather are merely indicative of reading. Such subtitles are not to be understood as being used for segmenting the content of the article, nor should the content under the subtitle be limited only to the scope of the subtitle.
The present disclosure provides a glucose solution formulation apparatus, the formulated glucose solution and PBS solution for providing various target concentrations of glucose solution or PBS solution to a sensing electrode electrochemical automated test apparatus.
Fig. 1 is a schematic diagram showing the structure of a glucose solution preparing apparatus 1 according to the example of the present embodiment, and fig. 2 is a schematic diagram showing the structure of a liquid reservoir 10, a first solution reservoir 11, and a second solution reservoir 12 according to the example of the present embodiment integrally connected.
In some examples, the glucose solution preparation apparatus 1 may include a fluid reservoir 10, a first solution reservoir 11, a first measurement module disposed in the first solution reservoir 11, a second solution reservoir 12, a second measurement module disposed in the second solution reservoir 12, a control module 13, and a display module 14.
Fig. 3 is a schematic diagram showing the structure of the liquid tank 10 according to the example of the present embodiment.
In some examples, the tank 10 may be used to store ultrapure water and deliver the ultrapure water to the first solution tank 11 through a pipe. The first solution tank 11 may receive ultrapure water transferred from the stock tank 10 and prepare a PBS solution using the ultrapure water. In some examples, the PBS solution may be referred to as a phosphate buffered solution. In other examples, the PBS solution may also be referred to as a 0mmol/L glucose solution. In some examples, the first solution tank 11 may deliver the formulated PBS solution to the second solution tank 12. In other examples, the first solution tank 11 may also deliver the formulated PBS solution to the dispensing barrels. In other examples, the first solution tank 11 may also deliver the formulated PBS solution to an external sensing electrode electrochemical automated test device.
In some examples, the first measurement module disposed at the first solution tank 11 may be configured to measure an amount of ultrapure water supplied to the first solution tank 11. In some examples, the first measurement module may measure the weight of ultrapure water. In another example, the first measurement module may also measure the level of ultrapure water.
In some examples, the PBS solution of the first solution tank 11 may be delivered to the second solution tank 12. The second measurement module may measure the amount of solution delivered to the second solution tank 12. In some examples, the second measurement module may measure the weight of the mixed solution of PBS solution and glucose solution. In other examples, the second measurement module may also measure the level of the mixed solution of PBS solution and glucose solution.
In some examples, the control module 13 may be configured to control the liquid storage tank 10 to supply ultrapure water to the first solution tank 11, and to control the supply speed of ultrapure water based on the measurement value of the first measurement module, and the supply speed of ultrapure water may be divided into a first supply speed, a second supply speed, and a third supply speed (described later in detail).
In some examples, the glucose solution preparation apparatus 1 may be connected to an external ultrapure water production apparatus to which the liquid reservoir 10 may be connected through a pipe, and the ultrapure water production apparatus may transmit ultrapure water to the liquid reservoir 10 through a pipe. Thereby, the ultrapure water producing apparatus can continuously supply ultrapure water to the glucose solution preparing apparatus 1.
In some examples, a PBS solute is required to be prepared before the PBS solution is prepared, the PBS solute may be composed of particles of sodium chloride, disodium hydrogen phosphate and sodium dihydrogen phosphate, the PBS solute with a target weight is placed into a beaker 1 filled with ultrapure water to be dissolved, after a period of dissolution, a PBS stock solution is formed, the PBS stock solution in the beaker 1 is poured into a first solution tank 11, then ultrapure water may be poured into the beaker 1 multiple times, and then the remaining PBS stock solution may be poured into the first solution tank 11 multiple times. Thereby, the PBS stock solution in the beaker 1 can be sufficiently poured into the first solution tank 11.
Fig. 4 is a schematic diagram showing the structures of the first solution tank 11 and the first weighing apparatus 111 according to the present embodiment example.
In some examples, the first measurement module may include a first weighing device 111 disposed at the bottom of the first solution tank 11, and the first weighing device 111 may measure the weight of the solution delivered to the first solution tank 11 (see fig. 4). In this case, the control module 13 is capable of controlling the delivery speed of the ultrapure water from the liquid storage tank 10 to the first solution tank 11 by measuring the weight of the solution in the first solution tank by the first weighing device 111.
In some examples, the first measurement module may further include a first level sensor disposed inside the first solution tank 11. The first level sensor may measure the level of the PBS solution in the first solution tank 11. In this case, the glucose solution preparing apparatus 1 can monitor the amount of the solution in the first solution tank 11 in real time by measuring the level of the PBS solution in the first solution tank 11 by the first level sensor.
In some examples, the glucose solution preparing apparatus 1 includes a first solution tank holder 113 for holding the first solution tank 11, the first solution tank holder 113 being provided with a first clamping mechanism 114, the first solution tank 11 further including a first stirring device 115, the first clamping mechanism 114 being capable of clamping the first solution tank 11 away from the first weighing apparatus 111 before the first stirring device 115 stirs the PBS solution of the first solution tank 11. Thus, when the first stirring device 115 stirs the PBS solution in the first solution tank 11, the shaking impact of the first solution tank 11 on the first weighing apparatus 111 during the stirring process can be reduced.
In some examples, the glucose solution preparing apparatus 1 may include a second solution tank holder 123 for holding the second solution tank 12. The second tank holder 123 may be provided with a second clamping mechanism 124. The second solution tank 12 may also include a second stirring device 125. In some examples, the second clamping mechanism 124 may clamp the second solution tank 12 off the second weighing apparatus 121 before the second stirring device 125 stirs the glucose solution of the second solution tank 12. Thus, when the second stirring device 125 stirs the glucose solution in the second solution tank 12, the shaking impact of the second solution tank 12 on the second weighing apparatus 121 during stirring can be reduced.
In some examples, the first measurement module may further include a PH sensor disposed inside the first solution tank 11, the PH sensor for measuring a PH value of the PBS solution in the first solution tank. In other examples, the first stirring device 115 stirs the PBS solution in the first solution tank 11, and after the PBS solution in the first solution tank 11 is stirred and mixed uniformly, the PH sensor measures the PH value of the solution in the first solution tank 11, and if the PH value is within the first preset range, the PBS solution in the first solution tank 11 is completely prepared.
In some examples, the first predetermined range may be a PH of 7.1 to 7.8.
In some examples, the glucose solution preparing apparatus 1 may include a first cleaning device disposed on the first solution tank 11, the first cleaning device configured to clean the first solution tank 11 prior to preparing the PBS solution. In other examples, the first cleaning device may be further configured to clean the first solution tank 11 after the PBS solution of the first solution tank 11 is drained.
In some examples, the glucose solution preparing apparatus 1 may further include a second cleaning device provided to the second solution tank 12. The second cleaning device may be configured to clean the second solution tank 12 before or after the glucose solution of the target concentration is formulated. In other examples, the second cleaning device may also be configured to clean the second solution tank 12 after the glucose solution of the second solution tank 12 is exhausted.
In some examples, glucose solute is required to be prepared before glucose solution is prepared, glucose solute may be composed of medical glucose particles, a certain weight of glucose solute is prepared and put into beaker 2 containing PBS solution with a pH value within a first preset range for dissolution, glucose solution can be formed after glucose solute is dissolved in PBS solution, glucose solution in beaker 2 is poured into second solution tank 12, PBS solution with a pH value within the first preset range can be poured into beaker 2 a plurality of times later, solution in beaker 2 is shaken, and residual glucose solution in beaker 2 can be poured into second solution tank 12 a plurality of times later.
Fig. 5 shows a schematic configuration diagram of the second solution tank 12 and the second weighing apparatus 121 according to the present embodiment example.
In some examples, the second measurement module may include a second weighing device 121 (see fig. 5) disposed at the bottom of the second solution tank 12, and the second weighing device 121 may measure the weight of the solution of the second solution tank 12, enabling accurate formulation of the concentration of the target glucose solution in the second solution tank 12 by monitoring the total weight of the solution of the second solution tank 12.
In some examples, the second measurement module may also include a second level sensor disposed inside the second solution tank 12. The second level sensor may measure the level of the solution in the second solution tank 12. In this case, by monitoring the level or volume of the solution in the second solution tank 12, the glucose solution of the target concentration in the second solution tank 12 can be accurately prepared.
In some examples, the second measurement module includes an analyzer disposed inside the second solution tank 12, which may measure a concentration of the glucose solution at a target concentration in the second solution tank 12. In other examples, the second stirring device 125 may stir the glucose solution in the second solution tank 12, and after the glucose solution in the second solution tank 12 is uniformly stirred, the analyzer may be capable of measuring the concentration of the glucose solution of the target concentration in the second solution tank 12, and if the measured value is within a second preset range of the target concentration, the preparation of the glucose solution of the target concentration is completed.
In some examples, the second solution tank 12 may dispense glucose solutions at concentrations of 2.2mmol/L, 5mmol/L, 10mmol/L, 15mmol/L, 20mmol/L, and 25mmol/L, respectively, and each concentration of glucose solution may be dispensed through a purge bin or may be delivered to a sensing electrode electrochemical automated testing device.
In some examples, PBS solutions having a pH in the range of 7.1 to 7.8 may also be referred to as 0mmol/L glucose solutions.
(PBS solution preparation)
Fig. 6 shows a flow chart of a PBS solution formulation method related to the present disclosure.
In some examples, prior to preparing the PBS solution, the first solution tank 11 includes a first cleaning device that cleans the first solution tank 11 and the cleaned solution is discharged from the first solution tank 11.
In some examples, as shown in fig. 6, a PBS stock solution is prepared (step S100), a target weight of PBS solute is dissolved in a beaker 1 containing ultrapure water to form a PBS stock solution, and the PBS stock solution dissolved in the beaker 1 may be poured into a first solution tank 11. In some examples, ultrapure water may be poured into the beaker 1 and rinsed a plurality of times, and the rinse solution in the rinsed beaker 1 may be poured into the first solution tank 11. Thereby, the PBS stock solution can be sufficiently poured into the first solution tank 11.
In some examples, the control module 13 controls the liquid-tank drawing pump 101 and the liquid-tank peristaltic pump 102 to draw ultrapure water from the liquid-tank 10 to the first solution tank 11 (step S110), and in other examples, the first measurement module measures the solution amount of the first solution tank 11, and the control module 13 controls the delivery rate of ultrapure water according to the solution amount of the first solution tank 11, that is, the control module controls the delivery rate of ultrapure water from the liquid-tank drawing pump 101 and the liquid-tank peristaltic pump to draw the liquid-tank 10 and deliver to the first solution tank 11.
In some examples, the control module 13 controls the liquid storage tank liquid drawing pump 101 and the liquid storage tank peristaltic pump 102 to draw ultrapure water of the liquid storage tank 10 and accurately add water to the first solution tank 11, the first measuring module measures the amount of solution in the first solution tank 11, and when the measured value of the first measuring module is lower than a first predetermined value, the control module 13 sends an instruction to the liquid storage tank liquid drawing pump 101, the liquid storage tank liquid drawing pump 101 will draw ultrapure water of the liquid storage tank 10 and transmit the ultrapure water to the first solution tank 11, and the ultrapure water is delivered at a first delivery speed.
In some examples, when the measured value of the first measurement module of the solution in the first solution tank 11 reaches the first predetermined value, the control module 13 issues an instruction to the tank suction pump 101, and the tank suction pump 101 will adjust the speed at which the ultrapure water pumped from the tank 10 is transferred to the first solution tank 11 to the second transfer speed.
In some examples, when the measured value of the first measurement module of the solution in the first solution tank 11 reaches the second predetermined value, the control module 13 issues an instruction to the tank suction pump 101, and the tank suction pump 101 stops pumping ultrapure water of the tank 10. The control module 13 sends out instructions to the liquid storage tank peristaltic pump 102, the liquid storage tank peristaltic pump 102 pumps ultrapure water of the liquid storage tank 10 to the first solution tank 11 in a precise manner, and the pumping speed of the ultrapure water is the third pumping speed. Thereafter, the control module 13 may adjust the feeding speed of the ultrapure water pumped by the liquid storage tank peristaltic pump 102 to the first solution tank 11, and the feeding speed may be adjusted to the fourth feeding speed, the fifth feeding speed or the sixth feeding speed, according to the measured value of the first measuring module. Thus, the PBS solution can be rapidly and accurately formulated.
In some examples, after the measured value of the first measurement module reaches the third predetermined value, the peristaltic pump 102 of the liquid storage tank 10 stops pumping ultrapure water, the first clamping mechanism 114 clamps the first solution tank off the first weighing device 111 of the first measurement module, and the first stirring device 115 stirs the PBS solution in the first solution tank 11 (step S120).
In some examples, step S130 is performed after the first stirring device 115 is completed to stir the PBS solution in the first solution tank 11, the PH sensor will measure the PH value of the PBS solution in the first solution tank 11, and if the PH value of the PBS solution is within the first predetermined range, the PBS solution preparation in the first solution tank 11 is completed.
In some examples, step S190 may output a portion of the PBS solution to a dispensing bucket or a sensing electrode electrochemical automated test device after the first solution tank 11 is completed with the PBS solution.
In some examples, if the PH sensor measures that the PH of the solution in the first solution tank 11 is below the first preset range, a small amount of PBS stock solution may be added to the first solution tank 11, and the control module 13 will calculate, based on the actual PH measurement, that a certain weight of PBS solute and ultrapure water be added, dissolve the PBS solute in the ultrapure water in the beaker 1, and pour it into the first solution tank 11. The first solution tank 11 stirs the PBS solution in the first solution tank 11 by the first stirring device 115, and after the PBS solution is uniformly mixed, the PH sensor measures the PH value of the solution in the first solution tank 11 again, and if the PH value is within the first preset range, the PBS solution preparation is completed.
In some examples, if the PH sensor measures that the PH of the solution in the first solution tank 11 is higher than the first preset range, a small amount of ultrapure water needs to be added to the first solution tank 11, the control module 13 will calculate from the actual PH measurement value that a certain weight of ultrapure water needs to be added again, and the control module 13 will control the peristaltic pump 102 of the liquid storage tank to accurately feed the first solution tank 11. The first solution tank 11 stirs the PBS solution in the first solution tank 11 by the first stirring device 115, and after the PBS solution is uniformly mixed, the PH sensor measures the PH value of the solution in the first solution tank 11 again, and if the PH value is within the first preset range, the PBS solution preparation is completed.
In some examples, the glucose solution apparatus further comprises a display module 14, the display module 14 may display the operating condition of the first solution tank 11 of the glucose solution preparation apparatus 1, and the display module 14 may switch the operating mode of the glucose solution preparation apparatus 1 to an automatic operating mode or a manual operating mode. Therefore, the working condition of the equipment can be well monitored and timely adjusted.
(preparation of glucose solution)
Fig. 7 shows a flow chart of a glucose solution formulation method according to the present disclosure.
In some examples, as shown in fig. 7, steps S100-S130 are consistent with the formulation of the PBS solution in fig. 6, with the PBS solution in the first solution tank 11 being delivered to the second solution tank 12 for formulation of a glucose solution of a target concentration.
In some examples, the second cleaning device of the second solution tank 12 may need to clean the second solution tank 12 before preparing the glucose solution of the target concentration, and the cleaned solution may be drained from the second solution tank 12.
In some examples, step S140 may be performed after the PBS solution is prepared in the first solution tank 11, by dissolving a target weight of glucose solute in the PBS solution beaker 2 having a PH within a first predetermined range to form a glucose solution, which may be poured into the second solution tank 12.
In some examples, the PBS solution having a pH within the first predetermined range may be poured into beaker 2 a plurality of times, beaker 2 may be shaken, and then the glucose solution in beaker 2 may be poured into second solution tank 12 a plurality of times.
In some examples, the control module 13 controls the first solution tank drawing pump 117 and the first solution tank peristaltic pump 118 to draw the PBS solution of the first solution tank 11 to the second solution tank 12 (step S150).
In some examples, in step S160, the second measurement module measures the amount of solution of the second solution tank 12, and the control module 13 controls the conveyance speed of the PBS solution according to the amount of solution of the second solution tank 12.
In some examples, the measurement value of the second measurement module may be the weight of the solution in the second solution tank 12 measured by the second weighing apparatus 121 (see fig. 5). In other examples, the measurement value of the second measurement module may also be the level of the solution in the second solution tank 12 measured by the second level sensor. Thereby, the second measuring module can measure the amount of solution in the second solution tank 12.
In some examples, when the measured value of the second measurement module of the solution in the second solution tank 12 is lower than the fourth predetermined value, the control module 13 may issue an instruction to the first solution tank pump 117, and the first solution tank pump 117 conveys the PBS solution that is pumped in the first solution tank 11 to the second solution tank 12, and the speed of conveyance of the PBS solution is the seventh conveyance speed.
In some examples, when the measured value of the second measurement module of the solution in the second solution tank 12 reaches the fourth predetermined value, the control module 13 may issue a command to the first solution tank pump 117, and the first solution tank pump 117 will adjust the conveyance speed of the PBS solution in the first solution tank 11 to the second solution tank 12 to be the eighth conveyance speed.
When the module measurement reaches the fifth predetermined value, the control module 13 may issue a command to the first solution tank pump 117, and the first solution tank pump 117 stops pumping the PBS solution of the first solution tank. The control module 13 sends a command to the first solution tank peristaltic pump 118, the first solution tank peristaltic pump 118 pumps the PBS solution of the first solution tank 11 and conveys the PBS solution into the second solution tank 12, and the conveying speed of the first solution tank peristaltic pump 118 pumping the PBS solution to the first solution tank 11 is a ninth conveying speed.
In some examples, control module 13 may also adjust first solution tank peristaltic pump 118 to pump PBS solution from first solution tank 11 to second solution tank 12 at a tenth, eleventh, or twelfth delivery rate based on measurements of a second measurement module of solution in second solution tank 12. Thus, the control module 13 can slowly add liquid to the second solution tank 12 by controlling the liquid adding speed of the first peristaltic pump 118, which can be advantageous for controlling the amount of solution in the second solution tank.
In some examples, control module 13 may also control the rate of delivery of the PBS solution from first solution tank 11 to second solution tank 12 based on a measured difference between the amount of solution in second solution tank 12 and a preset target weight of the second solution tank 12 formulation solution. In some examples, when the measured difference between the amount of solution in the second solution tank 12 and the preset target weight of the solution formulated by the second solution tank 12 is the fourth difference, the control module 13 issues an instruction to the first solution tank pump 117, and the first solution tank pump 117 will pump the PBS solution of the first solution tank 11 and deliver to the second solution tank 12, with the speed of the PBS solution delivery being the seventh delivery speed.
In some examples, the seventh delivery rate may be a seventh delivery rate that may deliver 5 kilograms of PBS solution to the second solution tank 12 for 1 minute. Thus, the first solution tank pump 117 can deliver the PBS solution to the second solution tank 12 at a faster rate.
In some examples, when the measured difference between the amount of solution in the second solution tank 12 and the preset target weight of the second solution tank 12 formulation solution is the fifth difference, the control module 13 issues a command to the first solution tank pump 117, and the first solution tank pump 117 adjusts the conveyance speed at which the PBS solution of the first solution tank 11 is pumped and conveyed to the second solution tank 12 to the eighth conveyance speed. In some examples, the eighth delivery rate may be 1 minute to deliver 3 kg of PBS solution to the second solution tank 12. Thus, the first solution tank pump 117 can reduce the conveying speed of the PBS solution to the second solution tank 12, which is beneficial to controlling the amount of solution in the second solution tank 12.
In some examples, when the measured difference between the amount of solution in the second solution tank 12 and the preset target weight of the second solution tank 12 formulation solution is the fifth difference, the control module 13 may instruct the first solution tank pump 117 to stop pumping the PBS solution of the first solution tank by the first solution tank pump 117. The control module 13 sends a command to the first solution tank peristaltic pump 118, the first solution tank peristaltic pump 118 pumps the PBS solution of the first solution tank 11 to the second solution tank 12 for precise liquid adding, the pumping speed of the PBS solution is a ninth conveying speed, and the ninth conveying speed can be 3 minutes to convey 1 kg of PBS solution to the second solution tank 12. Thus, the first solution tank peristaltic pump is capable of delivering the PBS solution to the second solution tank 12 at a slow delivery rate, which is advantageous in controlling the amount of solution in the second solution tank 12.
In some examples, the control module 13 may also adjust a delivery rate of the PBS solution from the first solution tank 11 to the first solution tank 11 by the first solution tank peristaltic pump 118 according to a measured difference between an amount of the solution in the second solution tank 12 and a preset target weight of the solution formulated by the second solution tank 12, and the delivery rate may be a tenth delivery rate, an eleventh delivery rate, or a twelfth delivery rate. Thus, the control module 13 can slowly charge the second solution tank 12 by controlling the charging speed of the first peristaltic pump 118.
In some examples, the ninth conveying speed may be higher than the tenth conveying speed. The tenth conveying speed may be higher than the eleventh conveying speed. The eleventh conveying speed may be higher than the twelfth conveying speed. Thus, the first solution tank peristaltic pump 118 is capable of delivering the PBS solution to the second solution tank 12 at a slow delivery rate, which is advantageous in controlling the amount of solution in the second solution tank 12.
In some examples, when the measurement value of the solution second measurement module in the second solution tank 12 reaches a sixth predetermined value, the control module 13 may instruct the first solution tank peristaltic pump 118, and the first solution tank peristaltic pump 118 stops pumping the PBS solution in the first solution tank 11.
In some examples, the control module 13 may also instruct the second solution tank support 123 when the measured value of the solution second measuring module in the second solution tank 12 reaches a predetermined value, the second solution tank support 123 being provided with a second clamping mechanism 124, the second clamping mechanism clamping the second solution tank 12 away from the second weighing apparatus 121.
In some examples, step S160 instructs the second stirring device 125 to start stirring the glucose solution in the second solution tank 12 by the control module 13 after the second clamping mechanism 124 clamps the second solution tank 12 off the second weighing apparatus 121. In this case, stirring the glucose solution of the second solution tank 12 does not generate impact to the second weighing apparatus 121, and the second weighing apparatus 121 can maintain a good measurement state.
In some examples, step S170 may instruct the control module 13 to an analyzer inside the second solution tank 12 after the stirring of the glucose solution in the second solution tank 12 is completed, the analyzer will measure the concentration of the glucose solution of the target concentration in the second solution tank 12, and if the concentration measurement of the glucose solution of the target concentration is within the second predetermined range, the preparation of the glucose solution of the target concentration in the second solution tank 12 is completed.
In some examples, where the analyzer measures a measured value of the glucose solution at the target concentration in the second solution tank 12, if the measured value is higher than a second preset range of the target concentration, a certain amount of the PBS solution needs to be added to the second solution tank 12, and the control module 13 may calculate the amount of the PBS solution that needs to be added according to the measured value of the analyzer. The control module 13 may control the peristaltic pump 118 of the first solution tank to pump the PBS solution in the first solution tank 11 to the second solution tank 12, the second stirring device 125 may stir the glucose solution in the second solution tank 12 again, the analyzer measures the glucose solution with the target concentration in the second solution tank 12, and if the measured concentration value of the measured glucose solution is within the second preset range of the target concentration, the preparation of the glucose solution with the target concentration is completed.
In some examples, the analyzer measures the glucose solution of the target concentration in the second solution tank 12, if the measured value of the glucose solution of the target concentration is lower than the second preset range of the target concentration, a certain solution amount of glucose solution needs to be added to the second solution tank 12, the glucose solution preparation device can calculate the solution amount and the PBS solution amount of the glucose solution to be added, the second solution tank 12 is poured after the glucose solute of the target mass is dissolved in the PBS solution of the target mass, the second stirring device 125 stirs the glucose solution in the second solution tank 12 again, the analyzer measures the glucose solution of the target concentration in the second solution tank 12, and if the measured value of the concentration of the measured glucose solution is within the second preset range of the target concentration, the glucose solution preparation of the target concentration is completed.
In some examples, the second cleaning device may require cleaning of the second solution tank 12 prior to the preparation of each concentration of glucose solution between the preparation of different concentrations of glucose solutions.
In some examples, the glucose solution preparation apparatus 1 further comprises a display module 14, the display module 14 being capable of displaying the operating conditions of the glucose solution preparation apparatus 1 and switching the automatic operation mode or the manual control mode of the glucose solution preparation apparatus 1 by manual input. In this case, the operator can conveniently monitor the working condition of the glucose solution preparing apparatus, and can adjust the working condition of the apparatus in time.
In some examples, the glucose solution preparation device 1 may also be connected to an external sensor electrode electrochemical automation test device, the control module 13 being configured to deliver a portion of the PBS solution to the sensor electrode electrochemical automation test device 1 after the PBS solution preparation of the first solution tank 11 is completed, the control module 13 being configured to deliver a prepared glucose solution of a target concentration to the sensor electrode electrochemical automation test device after the glucose solution preparation of the target concentration of the second solution tank 12 is completed.
In some examples, the control module 13 may also be configured to deliver the formulated PBS solution to the racking tanks after the PBS solution formulation of the first solution tank 11 is completed. In other examples, the glucose solution preparing apparatus 1 further comprises a data processing device, wherein the data processing device can store the prepared PBS solution related preparation data, and the data processing device can print the prepared PBS solution related label on the sub-packaging barrel. Therefore, the recorded data of the PBS solution in the related production process can be well stored and traced.
In some examples, the control module 13 may be further configured to deliver the glucose solution to the dispensing barrel after the completion of the dispensing of the glucose solution of the target concentration from the second solution tank 12, and the relevant dispensing data of the glucose solution of the target concentration after the completion of the dispensing may be stored in the data processing device, and the data processing device may further print a label of the relevant glucose solution of the target concentration dispensed on the dispensing barrel. Therefore, the production record data of the glucose solution with the target concentration in the related production process can be well stored and traced.
In order to further explain the present invention, the glucose solution preparing method provided by the present invention will be described in detail with reference to the following examples, in which the glucose solution preparing apparatus 1 is connected to an external ultrapure water maker, the glucose solution preparing apparatus 1 obtains ultrapure water from the ultrapure water maker to the liquid storage tank 10, the liquid storage tank 10 supplies ultrapure water to the first solution tank 11, and the first cleaning device cleans the first solution tank 11 before preparing the PBS solution. In some examples, the first cleaning device may be a 360 degree rotation showerhead and the first cleaning device may rotate 360 degrees to clean the first solution tank 11.
In some examples, referring to fig. 6, a pre-configured weight of PBS solute may be placed into a beaker 1 containing ultrapure water for dissolution, the PBS solute may be dissolved in the beaker 1 over a period of time to form a PBS stock solution, and the PBS stock solution dissolved in the beaker 1 may be poured into the first solution tank 11.
In some examples, ultrapure water may be poured into the beaker 1 and rinsed a plurality of times, and the rinse solution in the rinsed beaker 1 may be poured into the first solution tank 11. Thereby, the PBS stock solution can be sufficiently poured into the first solution tank 11.
In some examples, the control module 13 controls the reservoir pump 101 and the reservoir peristaltic pump 102 to pump ultrapure water from the reservoir 10 to the first solution tank 11 with precise water addition, and the first measurement module may measure the amount of solution in the first solution tank 11. When the measured value of the first measuring module is lower than the first predetermined value, the control module 13 gives an instruction to the liquid reservoir pump 101, and the liquid reservoir pump 101 will pump ultrapure water of the liquid reservoir 10 and transmit to the first solution tank 11, the speed of ultrapure water delivery being the first delivery speed.
In some examples, when the measured value of the first measurement module of the solution in the first solution tank 11 reaches the first predetermined value, the control module 13 may issue a command to the tank suction pump 101, and the tank suction pump 101 will adjust the speed at which the ultrapure water pumped up to the solution tank 10 is transferred to the first solution tank 11 to the second transfer speed.
In some examples, when the measured value of the first measurement module of the solution in the first solution tank 11 reaches the second predetermined value, the control module 13 may issue an instruction to the tank suction pump 101, and the tank suction pump 101 stops pumping ultrapure water of the tank 10. The control module 13 may send a command to the liquid storage tank peristaltic pump 102, where the liquid storage tank peristaltic pump 102 pumps ultrapure water from the liquid storage tank 10 to the first solution tank 11, and the pumping speed of the ultrapure water is the third pumping speed. Thereafter, the control module 13 may adjust the feeding speed of the ultrapure water pumped by the liquid storage tank peristaltic pump 102 to the first solution tank 11, and the feeding speed may be adjusted to the fourth feeding speed, the fifth feeding speed or the sixth feeding speed, according to the measured value of the first measuring module. Thus, the PBS solution can be rapidly and accurately formulated.
In some examples, after the measured value of the first measurement module reaches the third predetermined value, the peristaltic pump 102 of the liquid storage tank 10 stops pumping ultrapure water, the first clamping mechanism 114 clamps the first solution tank off the first weighing device 111 of the first measurement module, and the first stirring device 115 stirs the PBS solution in the first solution tank 11.
In some examples, after the first stirring device 115 is completed stirring the PBS solution in the first solution tank 11, the PH sensor will measure the PH of the PBS solution in the first solution tank 11, and if the PH of the PBS solution is within a first predetermined range, the PBS solution formulation of the first solution tank 11 is completed.
In some examples, the second cleaning device cleans the second solution tank 12 prior to preparing the glucose solution of the target concentration, and in some examples, the second cleaning device may also be a 360 degree rotating showerhead, and the second cleaning device may rotate 360 degrees and clean the second solution tank 12.
In some examples, the second cleaning device may also rotate 360 degrees in multiple directions and clean the second solution tank 12.
In some examples, referring to fig. 7, the second solution tank 12 prepares a glucose solution of a target concentration, a pre-configured weight of glucose solute is placed into the beaker 2 containing the prepared PBS solution having a PH within a first predetermined range for dissolution, and after a period of dissolution, the glucose solution in the pre-dissolved beaker 2 is poured into the second solution tank 12.
Alternatively, PBS solution having a pH within a first predetermined range may be added to beaker 2 a plurality of times, and the solution in beaker 2 may be shaken, and the glucose solution in beaker 2 may be added to second solution tank 12 a plurality of times.
In some examples, control module 13 may control first solution tank pump 117 to pump the formulated PBS solution from first solution tank 11 to purge second solution tank 12 prior to formulating the glucose solution of the target concentration. After the cleaning is completed, the control module 13 may start and stop the first solution tank pump 117 or the first solution tank peristaltic pump 118 in the first solution tank based on the measurement value of the second measurement module. When the measured value of the second measurement module 110 is lower than the fourth predetermined value, the first solution tank pump 117 may pump the PBS solution in the first solution tank 11 to the second solution tank 12 at the seventh conveying speed, and when the measured value of the second measurement module reaches the fourth predetermined value, the first solution tank pump 117 may pump the PBS solution in the first solution tank 11 to the second solution tank 12 at the eighth conveying speed. When the measured value of the second measurement module reaches the fifth predetermined value, the control module 13 may issue an instruction that the first solution tank pump 117 stops operating and the first solution tank peristaltic pump 118 pumps the PBS solution in the first solution tank 11, the first solution tank peristaltic pump 118 delivering the PBS solution to the second solution tank 12 at the ninth delivery rate. This enables the solution amount in the second solution tank 12 to be controlled well.
In some examples, the control module 13 may also adjust a delivery speed of the first solution tank peristaltic pump 118 to pump the PBS solution in the first solution tank 11 to the second solution tank 12 according to the measurement value of the second measurement module, and the delivery speed may be adjusted to a tenth delivery speed, an eleventh delivery speed, or a twelfth delivery speed. In this case, a glucose solution of a corresponding target concentration can be rapidly and accurately prepared.
In some examples, after the first solution tank peristaltic pump 118 pumps the PBS solution in the first solution tank 11 to the second solution tank 12 to reach the sixth predetermined value, the first solution tank peristaltic pump 118 may stop pumping the PBS solution in the first solution tank 11, the second clamping mechanism 124 clamps the second solution tank 12 off the second weighing device 121, and the second stirring device 125 stirs the glucose solution in the second solution tank 12. Thus, a glucose solution having a uniform concentration can be formed.
In some examples, after the second stirring device 125 is completed to stir the glucose solution in the second solution tank 12, the analyzer measures a target concentration of the glucose solution in the second solution tank 12, and if the measured concentration measurement of the glucose solution is within the target concentration range, the preparation of the target concentration of the glucose solution is completed. The glucose solution of the target concentration formulated by the second solution tank 12 may be capable of being dispensed in a barrel, and may be capable of being delivered to an external sensing electrode electrochemical automated testing device.
In some examples, the second solution tank 12 may accurately formulate 2.2mmol/L, 5mmol/L, 10mmol/L, 15mmol/L, 20mmol/L, and 25mmol/L glucose solutions, respectively. Glucose solutions of 2.2mmol/L, 5mmol/L, 10mmol/L, 15mmol/L, 20mmol/L, and 25mmol/L can be used for sensing electrode testing and calibration in continuous monitoring blood glucose products.
In some examples, the PBS solution formulated in the first solution tank 11 may be dispensed through a dispensing barrel, and in other examples, the PBS solution formulated in the first solution tank 11 may be directly delivered to an external sensor electrode electrochemical automated testing device.
In some examples, the glucose solution of the target concentration formulated in the second solution tank 12 may be dispensed via a dispensing barrel, and in other examples, the glucose solution of the target concentration formulated in the second solution tank 12 may also be directly delivered to an external sensor electrode electrochemical automated testing device.
In some examples, the second solution tank 12 may accurately formulate glucose solutions of other concentrations. The prepared glucose solution with other target concentration can be packaged by a packaging barrel or other containers.
While the disclosure has been described in detail in connection with the drawings and embodiments, it should be understood that the foregoing description is not intended to limit the disclosure in any way. Modifications and variations of the present disclosure may be made as desired by those skilled in the art without departing from the true spirit and scope of the disclosure, and such modifications and variations fall within the scope of the disclosure.

Claims (21)

1. A glucose solution preparation device is characterized by comprising a liquid storage tank, a first solution tank, a first measuring module, a second solution tank, a second measuring module and a control module, wherein the first measuring module and the second solution tank are arranged on the first solution tank,
the reservoir is configured to store ultrapure water and deliver ultrapure water to the first solution tank,
the first solution tank is configured to prepare a PBS solution using ultrapure water and to deliver the PBS solution to the second solution tank,
the first measurement module is configured to measure a solution quantity of the first solution tank,
the second solution tank is configured to formulate a glucose solution of a target concentration with a PBS solution,
the second measurement module is configured to measure a solution quantity of the second solution tank,
the control module is configured to control the liquid storage tank to supply ultrapure water to the first solution tank and control the speed of ultrapure water supply based on the measured value of the first measurement module,
the control module is configured to control the first solution tank to convey PBS solution to the second solution tank, and control the conveying speed of the PBS solution based on the measured value of the second measurement module.
2. The glucose solution preparing apparatus as set forth in claim 1, wherein,
The glucose solution preparation equipment is connected with the ultrapure water preparation equipment, and the liquid storage tank is connected with the ultrapure water preparation equipment through a pipeline.
3. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the first measurement module includes a first weighing device disposed at a bottom of the first solution tank, the first weighing device configured to measure a weight of the solution of the first solution tank.
4. The glucose solution preparing apparatus as set forth in claim 3, wherein,
the glucose solution preparation apparatus further includes a first solution tank holder for supporting the first solution tank and a second solution tank holder for supporting the second solution tank.
5. The glucose solution preparing apparatus as set forth in claim 4, wherein,
the first solution tank support is provided with a first clamping mechanism, the second solution tank support is provided with a second clamping mechanism, the first clamping mechanism is configured to clamp the first solution tank so that the first solution tank is separated from the first weighing device, and the second clamping mechanism is configured to clamp the second solution tank so that the second solution tank is separated from the second weighing device.
6. The glucose solution preparing apparatus as set forth in claim 5, wherein,
the first solution tank further comprises a first stirring device, the first stirring device is configured to stir the solution in the first solution tank after the first solution tank is separated from the first weighing equipment, and the second solution tank further comprises a second stirring device, and the second stirring device is configured to stir the solution in the second solution tank after the second solution tank is separated from the second weighing equipment.
7. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the first measurement module includes a first level sensor disposed inside the first solution tank, the first level sensor configured to measure a level of a solution in the first solution tank.
8. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the first measurement module includes a PH sensor disposed inside the first solution tank, the PH sensor configured to measure a PH value of a solution in the first solution tank.
9. The glucose solution preparing apparatus as set forth in claim 1, wherein,
The second measurement module includes a second level sensor disposed inside the second solution tank, the second level sensor configured to measure a level of solution in the second solution tank.
10. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the second measurement module includes an analyzer disposed inside the second solution tank, the analyzer configured to measure a concentration of a glucose solution in the second solution tank.
11. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the concentration of the glucose solution prepared in the second solution tank is 2.2mmol/L, 5mmol/L, 10mmol/L, 15mmol/L, 20mmol/L and 25mmol/L respectively.
12. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the liquid storage tank comprises a liquid storage tank liquid drawing pump and a liquid storage tank peristaltic pump, wherein the liquid storage tank liquid drawing pump pumps ultrapure water in the liquid storage tank into the first solution tank, and the liquid storage tank peristaltic pump pumps ultrapure water in the liquid storage tank into the first solution tank.
13. The glucose solution preparing apparatus as set forth in claim 1, wherein,
The control module starts and stops a liquid storage tank liquid pump or a liquid storage tank peristaltic pump in the liquid storage tank based on the measured value of the first measuring module.
14. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the first solution tank comprises a first solution tank liquid-drawing pump and a first solution tank peristaltic pump, the first solution tank liquid-drawing pump pumps PBS solution in the first solution tank to the second solution tank, and the first solution tank peristaltic pump pumps PBS solution in the first solution tank to the second solution tank in a precise liquid adding mode.
15. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the control module starts and stops a first solution tank liquid pump or a first solution tank peristaltic pump in the first solution tank based on the measured value of the second measurement module.
16. The glucose solution preparing apparatus according to claim 1 or 5, wherein,
the first solution tank further comprises a first stirring device, the first stirring device is configured to stir the solution in the first solution tank after the liquid storage tank stops delivering ultrapure water, and the second solution tank further comprises a second stirring device, and the second stirring device is configured to stir the solution in the second solution tank after the first solution tank stops delivering PBS solution.
17. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the glucose solution preparing apparatus further includes a first cleaning device disposed in the first solution tank, the first cleaning device configured to clean the first solution tank prior to preparing the PBS solution.
18. The glucose solution preparing apparatus as set forth in claim 1, wherein,
and (3) preparing glucose solutions with various concentrations by using the glucose solution preparation equipment, and cleaning the second solution tank between the glucose solutions with different concentrations.
19. The glucose solution preparing apparatus as set forth in claim 18, wherein,
the glucose solution preparing apparatus further includes a second cleaning device provided to the second solution tank, the second cleaning device being configured to clean the second solution tank before or after preparing the glucose solution of the target concentration.
20. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the glucose solution preparing apparatus further includes a display module that displays an operating condition of the glucose solution preparing apparatus and switches an automatic operation mode or a manual control mode of the glucose solution preparing apparatus by a manual input.
21. The glucose solution preparing apparatus as set forth in claim 1, wherein,
the control module is configured to convey a portion of the PBS solution to the sensing electrode electrochemical automatic testing device after the PBS solution in the first solution tank is prepared, and the control module is configured to convey the PBS solution to the sensing electrode electrochemical automatic testing device after the glucose solution with the target concentration in the second solution tank is prepared.
CN202210489891.6A 2022-05-07 2022-05-07 Glucose solution preparation equipment Pending CN117054176A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210489891.6A CN117054176A (en) 2022-05-07 2022-05-07 Glucose solution preparation equipment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210489891.6A CN117054176A (en) 2022-05-07 2022-05-07 Glucose solution preparation equipment

Publications (1)

Publication Number Publication Date
CN117054176A true CN117054176A (en) 2023-11-14

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Family Applications (1)

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CN202210489891.6A Pending CN117054176A (en) 2022-05-07 2022-05-07 Glucose solution preparation equipment

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Country Link
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