CN117054141A - Sampling and detecting integrated device and liquid inlet device - Google Patents

Abstract

The application relates to a sampling and detecting integrated device which can simultaneously realize the functions of collecting excrement, dissolving and diluting samples and detecting the excrement into a whole, and can realize the functions of sealing storage and quantitative transmission of liquid, in particular to a device which solves the problem that an effective test result cannot be always obtained when samples such as excrement and the like are detected, so that the proportion of the obtained effective test result reaches or basically reaches 100%. The application also relates to a liquid inlet device, which can solve the problem of unsmooth liquid flowing channel under the condition that the whole liquid inlet device completes operation in a relatively closed space, a sealing film at the bottom of liquid needs to be broken to enable the liquid to flow downwards, and the area of the bottom surface where the sealing film is positioned is limited, and improves the liquid inlet efficiency.

Description

Sampling and detecting integrated device and liquid inlet device

Technical Field

The application relates to a sampling and detecting integrated device and a liquid inlet device.

Background

The traditional stool sampling device is a stool storage device similar to a small box, and after sampling, the stool is diluted by a tester and dripped into the reaction box for several minutes to observe the result. Such sampling and detection processes have long separation times, are inconvenient, and can easily cause contamination and deterioration. Recently, there have been disclosed devices for integrating sampling and testing (hereinafter referred to as "integrated devices" or "devices"), such as those disclosed in WO2018/149131 and CN110018013a, each of which includes a cap, a main body container, a test medium (e.g., test paper) holder, a sampling rod, a reservoir, and the like, and in use, a fecal sample is taken with the tip of the sampling rod and inserted into the reservoir of the testing device. The fecal sample is mixed with the liquid in the liquid storage cavity to form a sample solution, then the bottom of the liquid storage cavity is poked by a user through a sampling rod, the sample solution flows into a cavity or a groove at the bottom from the poked opening and flows to the bottom end of the test medium, and then a color band appears on the running board on the test medium through siphoning, so that the user observes the detection result.

In the prior art, the tip of the sampling rod is used for sampling and also needs to be moved a distance to break the bottom of the reservoir, which determines that its size must be relatively small; however, the opening of the reservoir that is perforated at the bottom must be relatively small, which results in a poor downward flow path for the sample solution, and sometimes does not flow effectively to the test medium holder, and therefore cannot contact the test medium (or the test medium cannot contact a sufficient amount of sample solution), and thus cannot run on the test medium, resulting in an effective test result that cannot always be obtained. Because the integrated device is usually disposable, once an effective test result cannot be obtained, the device has to be replaced for retesting, which not only causes waste of test products and materials, but also causes waste of time and energy of testers because the fecal sample cannot be collected at any time.

Under the condition that liquid is needed in a similar condition to the stool sampling device, namely, the whole liquid feeding device completes operation in a relatively airtight space, the sealing film at the bottom of the liquid needs to be broken to enable the liquid to flow downwards, and the area of the bottom surface where the sealing film is located is limited, the same problem can occur, namely, the problem that a channel for the liquid to flow downwards is not smooth.

Disclosure of Invention

The application aims to provide a sampling and detection integrated device which can solve the problem that an effective test result cannot be always obtained when a sample such as excrement is detected.

In a first aspect of the application, the application relates to an integrated sampling and testing device, comprising a cover 2 and a main body container 6, wherein a sampling rod 3 is connected to the cover 2, the main body container 6 comprises a pipe cavity 122 on one side and a testing cavity 121 on the other side, a liquid receiving cavity 9 is arranged at the bottom of the main body container 6, a testing medium fixing seat 106 is arranged at a position below the testing cavity 121 in the liquid receiving cavity 9, one end of the testing medium 59 is fixed in the testing medium fixing seat 106, the other end extends into the testing cavity 121, and the integrated sampling and testing device is characterized in that an inner pipe 4 is arranged in the pipe cavity 122, the sampling rod 3 is inserted into an inner cavity 125 of the inner pipe 4, the top of the inner pipe 4 is sealed by the cover 2, the bottom of the inner pipe 4 is sealed by a sealing film 7, a puncture piece 8 is arranged at the bottom end of the pipe cavity 122, a knife edge 46 is arranged above the puncture piece 8, and a communicating pipe cavity 122 and a liquid outlet channel 47 of the liquid receiving cavity 9 are arranged in the puncture piece 8.

In one embodiment, a seal ring 5 is disposed between lumen 122 and inner tube 4.

In one embodiment, the sampling and detection integrated device of the present application includes a limit component, such as a limit block or limit catch.

In one embodiment, a separation layer 123 is arranged in the middle of the inner tube 4, a sample inlet hole 33 is arranged in the center of the separation layer 123, and the aperture of the sample inlet hole 33 is consistent with the cross-sectional shape of the sampling rod 3 and has a diameter compatible with the cross-sectional shape of the sampling rod.

In one embodiment, after the inner tube 4 is closed by the cap 2, the cap 2 is moved downward, and the inner tube 4 can be moved downward in synchronization with the cap 2.

In one embodiment, the inlet of the outlet channel 47 is located at the top surface, preferably the center of the top surface, of the piercing member 8.

In one embodiment, a lancing auxiliary member 100 is disposed on the top surface of the lancing element 8, the lancing auxiliary member 100 protrudes from the top surface of the lancing element 8, the height of the protrusions is not uniform, and the highest point of the protrusions is connected with the tip of the knife edge 46; preferably, the inlet of the liquid outlet channel 47 is located on the top surface of the piercing member 8, and the piercing aid 100 is ring-shaped and located around the inlet of the liquid outlet channel 47.

The sampling and detecting integrated device according to the first aspect of the application can effectively solve the problems, and simultaneously realize the functions of collecting excrement, dissolving and diluting samples and detecting the excrement, and the sealing storage and quantitative transmission of liquid, in particular to ensure that the proportion (also called as 'actual measurement rate' in the text) of the obtained effective test result reaches or basically reaches 100%.

In a second aspect the application relates to a liquid inlet device comprising a cover 2' and a body container 6', the body container 6' comprising a lumen 122', characterized in that the lumen 122' is provided with an inner tube 4', the top of the inner tube 4' being sealed with the cover 2', the bottom being sealed with a sealing film 7', and in that an upwardly directed knife edge 46' is provided in the lumen 122' at a position below the sealing film. In one embodiment, a seal ring 5' is disposed between lumen 122' and inner tube 4 '.

The person skilled in the art knows that the cap 2', the body container 6', the lumen 122', the inner tube 4', the sealing film 7', the knife edge 46' and the optional sealing ring 5' of the second aspect of the present application correspond to the cap 2, the body container 6, the lumen 122, the inner tube 4, the sealing film 7, the knife edge 46 and the optional sealing ring 5 of the first aspect, respectively, and thus the liquid inlet device of the second aspect has been implicitly disclosed in the sampling and detection integrated device of the first aspect, and can be directly and unambiguously obtained from the sampling and detection integrated device of the first aspect.

Under the conditions that the whole liquid inlet device completes operation in a relatively airtight space, the sealing film at the bottom of the liquid needs to be broken to enable the liquid to flow downwards, and the area of the bottom surface where the sealing film is located is limited, the liquid inlet device in the second aspect of the application can solve the problem that a downward flowing channel of the liquid is not smooth, and improves the liquid inlet efficiency. The second aspect of the application is therefore applicable to the integrated sampling and detection device of the first aspect of the application, as well as to similar situations as described above. The shape, position, etc. of the fluid passages and knife edge 46' in the fluid inlet device can be specifically set by those skilled in the art according to actual needs.

Drawings

Fig. 1 is a schematic structural view of an integrated device of the present application.

Fig. 2 is a schematic view of an embodiment of the inner tube 4 in the device of the application.

Fig. 3 is a schematic view of an embodiment of the piercing member 8 of the device of the application, wherein a is a longitudinal section, B is a top view, and C is a perspective view (the foregoing views are for reference only to the component structure, and the projection relationship may be inconsistent, but does not affect the overall presentation of the structure).

Fig. 4 is a schematic structural diagram of a sample injection device of the present application.

Detailed Description

In order to solve the problem that the opening poked by the tip of the sampling rod is too small to cause unsmooth liquid circulation in the prior art, the sampling and detecting integrated device disclosed by the application does not follow the technical thought that the opening is poked from the upper part in the prior art, but pokes the opening from the lower part, so that the opening can be enlarged, and the liquid flow can be promoted by virtue of a gas-liquid exchange principle, so that the sample solution is promoted.

Specifically, at the time of sampling, the cap 2 is opened, a sample is collected by the tip of the sampling rod 3 (for example, by bringing the sampling portion into contact with the sample), the sampling rod 3 is inserted back into the inner cavity 125 of the inner tube 4, the inner cavity 125 of the inner tube 4 is sealed by the cap 2, and the device is flicked to sufficiently dissolve the sample in the solution. During detection, the inner tube 4 is moved downwards (for example, the inner tube 4 can be set to be capable of moving downwards synchronously with the cover 2, at the moment, the inner tube 4 is moved by moving the cover 2 downwards), so that the knife edge 46 of the puncture member 8 is poked through the sealing film 7 at the bottom end of the inner tube 4 from below, at the moment, gas exchange starts, and the gas in the tube cavity 122 enters the inner cavity 125 of the inner tube 4 through the small hole formed by the knife edge; with further downward movement of the inner tube 4, the piercing member 8 can break through the sealing membrane 7 with a larger area, so that the pierced opening is enlarged; and the sample solution is further pushed to flow out of the liquid outlet channel 47 due to sufficient air pressure in the cavity 125 caused by the air-liquid exchange. Thereby, the sample solution can flow into the liquid receiving tank 9 more smoothly, solving the aforementioned technical problems in the prior art.

The technical scheme of the sampling and detecting integrated device of the application is specifically described below.

In one embodiment, lumen 122 may be, for example, cylindrical and test lumen 121 may be, for example, rectangular. In one embodiment, the top of the test chamber 121 may be vented to allow the air pressure inside and outside the integrated device to be balanced.

In one embodiment, the sampling rod 3 head end has a grooved structure (e.g., a threaded structure) to facilitate sampling.

In one embodiment, the lumen 125 of the inner tube 4 holds a liquid (e.g., buffer, etc.) known in the art for dissolving the sample in an amount sufficient to sufficiently dissolve the sample on the sampling wand 3 to form a sample solution.

In one embodiment, lumen 122 and the upper portion of inner tube 4 may be closed by cap 2 at the same time, or lumen 122 may be closed by inner tube 4. For example, a seal ring 5 may be provided between the lumen 122 and the inner tube 4, which may both prevent liquid from escaping from the gap between the lumen 122 and the inner tube 4 and help promote gas-liquid exchange. Those skilled in the art will appreciate that, to enable the purposes of the present application, the seal ring 5 should not cause relative movement between the lumen 122 and the inner tube 4; during the test, the sealing ring 5 preferably remains sealed throughout the relative movement of the lumen 122 and the inner tube 4. It should be noted that "sealing ring" is to be understood broadly herein as all configurations capable of sealing between the inner wall of lumen 122 and the outer wall of inner tube 4, i.e. also including sealing rings, gaskets or other shaped sealing structures capable of producing the same effect.

In one embodiment, a separation layer 123 is arranged in the middle of the inner tube 4, a sample injection hole 33 is formed in the center of the separation layer 123, and the aperture of the sample injection hole 33 is consistent with the cross section shape of the sampling rod 3 (for example, the sample injection hole is round) and has a diameter suitable for the diameter, so that when the sampling rod 3 with a sample passes through, the sample injection hole can be sealed by the sampling rod 3, and the excessive sample on the surface of the sampling rod 3 can be scraped, so that the sample solution can be prevented from overflowing. The sampling rod 3 may be further provided with a sealing member at a position corresponding to the sampling hole 33 to enhance the sealing effect therein. In another embodiment, to facilitate the passage of the sampling rod 3, the top surface of the barrier 123 may be configured as a funnel with the sample inlet 33 at the bottom of the funnel.

In one embodiment, test medium 59 may be a dipstick or any other test medium known in the art.

In one embodiment, the integrated device of the present application may contain a stop assembly to prevent inadvertent pushing of the cap 2 when it is not desired (e.g., when it has not been sampled yet) to allow the sealing membrane 7 to be poked open. The limiting component can be a limiting block (refer to WO 2018/149131) or a limiting buckle (refer to CN110018013 a), for example.

In one embodiment, the test chamber 121 may be integrally formed of a transparent material or may have a transparent window to allow a user to view the running board from the outside and determine the detection result.

In one embodiment, the sealing film 7 is made of a material that can achieve both good sealing and is easily pierced, such as an aluminum foil film or a plastic film. In one embodiment, the sealing film 7 is sealed by means of heat sealing.

In one embodiment, when the cap 2 is moved downward after the inner tube 4 is closed by the cap 2, the inner tube 4 can be moved downward in synchronization with the cap 2, and when moved downward until the sealing film 7 contacts the knife edge 46, the knife edge starts to scratch the sealing film 7. Further downward moving of the inner tube 4, the sealing film 7 may be partially or entirely destroyed by the piercing member 8.

In one embodiment, the shape, size and height of the penetrating member 8 are not particularly limited, and may be, for example, cylindrical, conical, frustoconical, or the like. The inlet and shape of the liquid outlet channel 47 and the number, position and shape of the knife edges 46 are not particularly limited as long as it is ensured that the sample solution can flow into the liquid outlet channel 47 after the sealing film 7 is peeled off, and those skilled in the art can design the liquid outlet channel according to the actual situation. For example, the inlet of the liquid outlet channel 47 may be located at the top surface, preferably the center of the top surface, of the piercing member 8, and the number of the knife edges 46 may be 1, 2, 3, 4 or more; when the number of the knife edges 46 is more than 2, the knife edges can be symmetrically distributed around the center of the top surface of the puncture member 8, and the shape and the size of the knife edges can be the same or different.

In a more preferred embodiment, in order to enhance the puncturing effect, a puncturing aid 100 may be disposed on the top surface of the puncturing element 8, wherein the puncturing aid 100 protrudes from the top surface of the puncturing element 8, the height of the protrusions is not uniform, and the highest point of the protrusions is connected with the tip of the knife edge 46; in a still more preferred embodiment, the inlet of the liquid outlet channel 47 is located on the top surface of the piercing member 8, and the piercing aid 100 is annular and located around the inlet of the liquid outlet channel 47. This structure helps to break the sealing film 7 more rapidly during the downward movement of the inner tube 4, while achieving gas-liquid exchange, facilitating the outflow of the sample solution from the liquid outlet channel 47.

The sampling and detecting integrated device of the present application will be described in more detail with reference to the drawings. The structures illustrated in the figures are for illustrative purposes only and are not intended to limit the scope of the present application.

One general embodiment of the integrated sampling and testing device of the present application is shown in the schematic diagram of fig. 1, in which the general configuration and positional relationship among the cap 2, the sampling rod 3, the main body container 6, the testing chamber 121, the lumen 122, the inner tube 4, the inner cavity 125 of the inner tube 4, the sealing film 7, the piercing member 8, the knife edge 46, the liquid outlet channel 47, the liquid receiving chamber 9, the testing medium fixing seat 106, and the testing medium 59 are shown.

An embodiment of the inner tube 4 of the present application is shown in fig. 2, in which a top surface 32 (which is a portion closed by the cap 2 in this embodiment), a partition layer 123, a sample introduction hole 33, a seal ring 5, and a sealing film 7 are shown, and the top surface of the partition layer 123 is funnel-shaped.

One embodiment of the lancing element 8 of the present application is shown in FIG. 3 (for ease of reference of positional relationship, while showing a portion of the test medium 59), wherein the outlet channel 47, lancing auxiliary 100 and knife edge 46 are shown, the inlet of the outlet channel 47 being centered on the top surface of the lancing element 8; the number of the knife edges 46 is 4, the knife edges have different heights and are arrayed in a cross shape around the center of the top surface of the puncture member 8; the lancing aid 100 is located at the inlet periphery of the liquid outlet channel 47, and its highest point of projection is connected to the highest knife edge of the 4 knife edges 46.

In order to verify the technical effects obtained by the present application, the device having the basic structure shown in fig. 1, the inner tube 4 shown in fig. 2, and the piercing member 8 shown in fig. 3 was used to perform the test operation by the test person and the non-test person, the non-test person operated 200 sets, the test person operated 1800 sets, and the test by the 2000 sets of test devices were performed cumulatively, wherein the test person was a professional who performed the product development and test by the present company, and the non-test person was a person who performed no related work related to the product development and test by the present company. In the test operation by the test person and the non-test person, the actual measurement rate was 100%.

One general embodiment of the liquid inlet device of the present application is shown in the schematic view of fig. 4, in which the general construction and positional relationship between the cap 2', the main body container 6', the lumen 122', the inner tube 4', the inner cavity 125' of the inner tube 4', and the sealing film 7' are shown, which are consistent with the corresponding components in the integrated sampling and detecting device shown in fig. 1. The knife edge 46' and the specific path of the liquid after it has flowed down are not shown in fig. 4 and can be designed by a person skilled in the art according to the actual situation and requirements.

The sampling and detecting integrated device of the present application is a scenario to which the liquid feeding device of the present application is applied, and in the case where the effect of the sampling and detecting integrated device of the present application has been verified in the foregoing, those skilled in the art can recognize that the liquid feeding device of the present application can achieve such effects: the liquid inlet device is integrally operated in a relatively airtight space, the sealing film at the bottom of the liquid needs to be broken to enable the liquid to flow downwards, and the area of the bottom surface where the sealing film is located is limited, so that the problem that a channel for the liquid to flow downwards is not smooth is solved, and the liquid inlet efficiency is improved.

The terms "upper" and "lower" as used herein with respect to the sampling and testing integrated device ("top" and "bottom") refer to the orientation of the integrated device when placed upright. The orientations "up" and "down" ("top" and "bottom") used in describing the fluid intake device in this specification are all intended to correspond to the orientations referred to in describing the integrated device.

It will be appreciated by those skilled in the art that modifications (additions and/or deletions) may be made to the parts, structures, movements, and fittings described herein without departing from the full scope and spirit of the application, which is intended to cover such modifications and any and all equivalents thereof.

Claims (11)

1. The utility model provides an integrated device is detected in sample, it includes lid (2) and main part container (6), be connected with sampling rod (3) on lid (2), main part container (6) contain lumen (122) and test chamber (121) of opposite side of one side, there is liquid receiving cavity (9) main part container (6) bottom, there is test medium fixing base (106) in the position of test chamber (121) below in liquid receiving cavity (9), one end of test medium (59) is fixed in test medium fixing base (106), the other end extends to in test chamber (121), a serial communication port, place inner tube (4) in lumen (122), sampling rod (3) insert in inner tube (4) inner chamber (125), the top of inner tube (4) is sealed with lid (2), the bottom is sealed with sealing membrane (7), and lumen (122) bottom has puncture piece (8), there is communicating pipe (46) puncture piece (8) top, there are liquid passage (47) of lumen (122) and liquid receiving cavity (9) in puncture piece (8).

2. The integrated sampling and testing device according to claim 1, characterized in that a sealing ring (5) is arranged between the lumen (122) and the inner tube (4).

3. The integrated sampling and testing device of any one of claims 1-2, comprising a limiting assembly.

4. The integrated sampling and testing device of claim 3, wherein the stop assembly is a stop block or a stop catch.

5. The integrated sampling and detection device according to any one of claims 1 to 4, wherein a separation layer (123) is arranged in the inner tube (4), a sample inlet hole (33) is arranged in the center of the separation layer (123), and the aperture of the sample inlet hole (33) is consistent with the cross-sectional shape and the diameter of the sampling rod (3) is compatible.

6. The integrated sampling and testing device according to any one of claims 1-5, characterized in that the inlet of the outlet channel (47) is located at the top surface of the piercing member (8).

7. The integrated sampling and testing device according to claim 6, characterized in that the inlet of the liquid outlet channel (47) is located in the center of the top surface of the piercing member (8).

8. The integrated sampling and testing device according to any one of claims 1-7, characterized in that a penetration aid (100) is arranged on the top surface of the penetration member (8), said penetration aid (100) protruding from the top surface of the penetration member (8) with a non-uniform height, the highest point of the protrusion being connected to the tip of the knife edge (46).

9. The integrated sampling and testing device according to claim 8, characterized in that the inlet of the liquid outlet channel (47) is located on the top surface of the piercing member (8), and the piercing aid (100) is ring-shaped and located around the inlet of the liquid outlet channel (47).

10. A liquid inlet device comprising a cover (2 ') and a main body container (6 '), wherein the main body container (6 ') comprises a tube cavity (122 '), characterized in that an inner tube (4 ') is placed in the tube cavity (122 '), the top of the inner tube (4 ') is sealed by the cover (2 '), the bottom is sealed by a sealing film (7 '), and an upward knife edge (46 ') is arranged at a position below the sealing film in the tube cavity (122 ').

11. The liquid inlet device according to claim 10, characterized in that a sealing ring (5 ') is arranged between the lumen (122 ') and the inner tube (4 ').