CN117017400A - Medical oncology medicine intervention treatment device - Google Patents
Medical oncology medicine intervention treatment device Download PDFInfo
- Publication number
- CN117017400A CN117017400A CN202311060236.XA CN202311060236A CN117017400A CN 117017400 A CN117017400 A CN 117017400A CN 202311060236 A CN202311060236 A CN 202311060236A CN 117017400 A CN117017400 A CN 117017400A
- Authority
- CN
- China
- Prior art keywords
- blood
- bridge plug
- tumor
- built
- tube
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 25
- 238000011282 treatment Methods 0.000 title claims abstract description 18
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 78
- 230000036770 blood supply Effects 0.000 claims abstract description 73
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 46
- 239000008280 blood Substances 0.000 claims abstract description 45
- 210000004369 blood Anatomy 0.000 claims abstract description 41
- 230000002792 vascular Effects 0.000 claims abstract description 37
- 230000004087 circulation Effects 0.000 claims abstract description 30
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 28
- 239000001301 oxygen Substances 0.000 claims abstract description 28
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 25
- 210000003462 vein Anatomy 0.000 claims abstract description 18
- 210000000709 aorta Anatomy 0.000 claims abstract description 17
- 239000012528 membrane Substances 0.000 claims abstract description 8
- 230000017531 blood circulation Effects 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 25
- 229940041181 antineoplastic drug Drugs 0.000 claims description 17
- 238000003780 insertion Methods 0.000 claims description 6
- 230000037431 insertion Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 abstract description 26
- 230000000694 effects Effects 0.000 abstract description 9
- 201000011510 cancer Diseases 0.000 abstract description 7
- 208000005189 Embolism Diseases 0.000 abstract description 5
- 206010027476 Metastases Diseases 0.000 abstract description 4
- 230000009401 metastasis Effects 0.000 abstract description 4
- 210000001367 artery Anatomy 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 241000699670 Mus sp. Species 0.000 description 7
- 238000004088 simulation Methods 0.000 description 7
- 238000012549 training Methods 0.000 description 7
- 238000002512 chemotherapy Methods 0.000 description 6
- 210000004881 tumor cell Anatomy 0.000 description 6
- 239000002246 antineoplastic agent Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 238000000338 in vitro Methods 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 230000003073 embolic effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 230000004614 tumor growth Effects 0.000 description 2
- LHGMHYDJNXEEFG-UHFFFAOYSA-N 4-[4-(dimethylamino)phenyl]iminocyclohexa-2,5-dien-1-one Chemical compound C1=CC(N(C)C)=CC=C1N=C1C=CC(=O)C=C1 LHGMHYDJNXEEFG-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000010109 chemoembolization Effects 0.000 description 1
- 238000011281 clinical therapy Methods 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000011254 conventional chemotherapy Methods 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000005909 tumor killing Effects 0.000 description 1
- 210000003708 urethra Anatomy 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses a medical oncology medicine interventional therapy device, which comprises a guide wire, an internal tube and a blood vessel bridge plug, wherein the guide wire extends into a blood supply aorta of a tumor and a blood return vein of the tumor; the end part of the built-in pipe extending to the outside of the body is provided with a mounting hole, a blood circulation joint and an oxygen supply joint; also comprises an external blood supply machine; the invention utilizes the guide wire to place the built-in tube and the vascular bridge plug along the blood vessel to the position close to the blood supply of the tumor, the oxygen membrane bag on the side wall of the vascular bridge plug is inflated by injecting oxygen for pressurization, the embolism of the blood supply aorta of the tumor is carried out, the built-in tube and the vascular bridge plug form an extracorporeal circulation pipeline at the two ends of the blood supply and blood return of the tumor, the blood supply and blood return system of the tumor are isolated independently, and simultaneously, the medicine treatment and the extracorporeal blood supply are carried out, the metastasis of cancer cells is avoided, and the rehabilitation effect of the interventional therapy of the tumor medicine is improved.
Description
Technical Field
The invention belongs to the technical field of other instruments for introducing media into a body, and particularly relates to a medical oncology drug interventional therapy device.
Background
In modern medicine, there are many pre-cancer treatment methods, wherein the main treatment methods include chemotherapy, radiation therapy and excision therapy, and the above methods achieve the purpose of treating cancer by directly or indirectly destroying tumor cells, and the corresponding medicines need to be injected into the tumor positions, so as to provide a medicine foundation for the subsequent treatment process.
In the treatment of gastroenterology and oncology, an interventional treatment method is generally adopted, and currently, tumor interventional treatment is a minimally invasive tumor treatment method for precisely treating tumors or relieving symptoms under the guidance of X-ray, CT, MRI or ultrasonic imaging equipment, wherein the tumor interventional treatment is divided into vascular interventional treatment and non-vascular interventional treatment.
The vascular intervention is that through super-selection, anticancer drugs and vascular obstructive positions are filled in the blood supply arteries of the tumor, the drugs are locally filled into the tumor, so that the concentration of the local antitumor drugs is improved, the blood supply arteries of the tumor can be embolized, the tumor killing effect is enhanced, and the toxic and side effects on the whole body are small; non-vascular intervention refers to percutaneous aspiration of viscera through a natural opening or diameter of a physiological cavity of a human body by using various instruments outside blood vessels under the guidance of medical imaging equipment, and mainly comprises percutaneous aspiration biopsy technology, endoprosthesis, percutaneous tumor ablation and radioactive particle implantation.
The vascular intervention comprises two vascular interventions, namely catheter arterial infusion chemotherapy (TAI) and catheter arterial chemotherapy embolism (TACE), which are gradually matured in the clinical operation process, wherein the anti-tumor drugs are selectively injected into the tumor blood supply arteries through the catheter by the catheter arterial infusion chemotherapy (TAI), so that the purposes of improving the concentration of the tumor tissue drugs and enhancing the anti-tumor effect of the perfusion area are achieved, the anti-tumor effect can be obviously provided compared with the conventional chemotherapy, the oxygen supply arteries of the tumor are found through the catheter arterial chemotherapy embolism (TACE), the anti-tumor drugs and the embolic agents are simultaneously injected into the oxygen supply arteries of the tumor by the catheter technology, the peripheral vascular branches of the blood supply arteries of the tumor tissue are occluded, the anti-tumor drugs are slowly released in the tumor area, and the local radiotherapy effect is achieved, and the vascular intervention has the advantages that: 1) The medicine is locked in local part to exert the maximum anti-tumor effect and under the effect of systemic toxicity, 2) the blood supply vessel of the tumor is blocked, so that the tumor loses blood supply, thereby inhibiting the growth of the tumor.
Among them, both transcatheter arterial infusion chemotherapy (TAI) which does not prevent cancer cells from transferring to other sites via blood, and Transcatheter Arterial Chemoembolization (TACE) which easily causes normal tissue near a tumor to die quickly by stopping blood supply and also embolizes peripheral vascular branches of blood supply arteries of tumor tissue with great difficulty, have significant drawbacks, and thus a new interventional therapeutic device is required.
Disclosure of Invention
Therefore, the invention aims to provide a medical oncology medicine interventional therapy device, which is provided with a guide wire and an inner catheter along a tumor blood supply artery and blood return veins in a patient, wherein the end part of the inner catheter is provided with a blood vessel bridge plug, the inner catheter and the blood vessel bridge plug are placed in a position close to the tumor blood supply along a blood vessel by using the guide wire, an oxygen membrane bag on the side wall of the blood vessel bridge plug is inflated by injecting oxygen for pressurizing, the tumor blood supply artery is embolized, an extracorporeal circulation pipeline is formed at the two ends of the tumor blood supply blood return by using the inner catheter and the blood vessel bridge plug, a tumor blood supply blood return system is isolated independently, medicine therapy and extracorporeal blood supply are carried out, cancer cell metastasis is avoided, and the rehabilitation effect of the tumor medicine interventional therapy is improved.
In order to achieve the aim, the medical oncology medicine interventional therapy device comprises a guide wire extending into a tumor blood supply aorta, an inner catheter sleeved on the guide wire, a guide wire I extending into a tumor blood return vein and an inner catheter I sleeved on the guide wire I, wherein the ends of the inner catheter and the inner catheter I are respectively provided with a vascular bridge plug for embolizing the blood supply aorta and a vascular bridge plug I for embolizing the blood return vein, the outer walls of the vascular bridge plug and the vascular bridge plug I are respectively provided with a containing groove, the containing groove is internally provided with an oxygen membrane bag for inflating oxygen,
a central channel is arranged in the built-in tube and around the guide wire, a liquid outlet cavity communicated with the central channel is arranged in the blood vessel bridge plug and around the guide wire, and a liquid outlet communicated with one side of the blood supply aorta close to the tumor is arranged at the end part of the blood vessel bridge plug;
a central channel I is arranged in the built-in tube I and around the guide wire I, a liquid inlet cavity communicated with the central channel I is arranged in the vessel bridge plug I and around the guide wire I, and a liquid inlet communicated with one side of a blood return vein close to a tumor is arranged at the end part of the vessel bridge plug I;
the end part of the built-in tube extending to the outside of the body is provided with a mounting hole for accommodating the insertion of a guide wire, and the side wall of the built-in tube extending to the outside of the body is provided with a blood circulation joint and an oxygen supply joint;
the end part of the built-in tube I extending to the outside of the body is provided with a mounting hole I for accommodating insertion of a guide wire I, and the side wall of the built-in tube I extending to the outside of the body is provided with a blood return circulation joint and an oxygen supply joint I;
the blood supply device also comprises an external blood supply machine, wherein an external circulation pipeline is arranged on the external blood supply machine, and two ends of the external circulation pipeline are communicated with a blood supply circulation joint and a blood return circulation joint.
Further, the guide wire is set to 0.8mm-1.2mm.
Further, the diameter of the inner tube and the inner tube I is set to be 1.8-2mm.
Further, the diameters of the blood vessel bridge plug and the blood vessel bridge plug I are set to be 2-2.4mm, a conical surface is arranged on the blood vessel bridge plug, which is close to the edge, at the end part of the other end of the blood vessel bridge plug, which is far away from the liquid outlet, a blood supply hole communicated with one end of the tumor blood supply aorta, which is far away from the tumor, is arranged on the conical surface, and a blood supply channel which is communicated with the blood supply hole and the liquid outlet cavity is arranged on the blood vessel bridge plug.
Further, the built-in tube and the vascular bridge plug are arranged into an integral molding body, and the vascular bridge plug is formed by laser processing of medical PC materials.
The invention has the beneficial effects that:
the medical oncology medicine interventional therapy device is provided with a guide wire and an internal tube in a patient along a tumor blood supply artery and a blood return vein, the end part of the internal tube is provided with a blood vessel bridge plug, the internal tube and the blood vessel bridge plug are placed in the position close to the tumor blood supply along a blood vessel by using the guide wire, an oxygen membrane bag on the side wall of the blood vessel bridge plug is inflated by injecting oxygen for pressurizing, the embolism tumor blood supply aorta is carried out, an extracorporeal circulation pipeline is formed at the two ends of the tumor blood supply blood return by using the internal tube and the blood vessel bridge plug, a tumor blood supply blood return system is isolated independently, medicine therapy and extracorporeal blood supply are carried out, cancer cell metastasis is avoided, and the rehabilitation effect of the tumor medicine interventional therapy is improved.
Drawings
FIG. 1 is a schematic structural view of a medical oncology drug interventional therapy device of the present invention;
FIG. 2 is a vertical partial enlarged view of a vascular bridge plug in the medical oncology drug interventional therapy device of the present invention;
FIG. 3 is a cross-sectional enlarged view of a vascular bridge plug in the medical oncology drug interventional therapy device of the present invention;
fig. 4 is a schematic structural diagram of an extracorporeal circulation pipeline of the medical oncology drug interventional therapy device.
Reference numerals: 1-tumor; 2-blood supply aorta; 3-blood return vein; 4-tumor blood capillaries; 5-normal blood capillaries; 6-a guide wire; 7-a built-in tube; 8-vessel bridge plug; 9-a guide wire I; 10-a built-in pipe I; 11-vascular bridge plug I; 12-a receiving groove; 13-oxygen membrane vesicles; 14-a central passage; 15-a liquid outlet cavity; 16-a liquid outlet; 17-blood supply channel; 18-supplying blood holes; 19-an oxygen manifold; 20-oxygen passage; 21-blood circulation joint; 22-oxygen supply joint; 23-a blood return circulation junction; 24-an oxygen supply joint I; 25-an extracorporeal circulation circuit; 26-an in vitro blood supply machine.
Description of the embodiments
Preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
1-4 are schematic structural views of the medical oncology drug interventional therapy device of the invention; the invention discloses a medical medicine interventional therapy device for oncology, which comprises a guide wire 6 extending into a blood supply aorta 2 of a tumor 1, an embedment tube 7 sleeved on the guide wire 6, a guide wire I9 extending into a blood return vein 3 of the tumor 1, and an embedment tube I10 sleeved on the guide wire I9, wherein the ends of the embedment tube 7 and the embedment tube I10 are respectively provided with a vascular bridge plug 8 for embolizing the blood supply aorta and a vascular bridge plug I11 for embolizing the blood return vein, the outer walls of the vascular bridge plug 8 and the vascular bridge plug I11 are respectively provided with a containing groove 12, the containing groove 12 is internally provided with an oxygen membrane bag 13 for inflating oxygen,
a central channel 14 is arranged in the inner tube 7 around the guide wire 6, a liquid outlet cavity 15 communicated with the central channel 14 is arranged in the blood vessel bridge plug 8 around the guide wire 6, and a liquid outlet 16 communicated with one side of the blood supply aorta 2 close to the tumor is arranged at the end part of the blood vessel bridge plug 8;
a central channel I is arranged in the built-in tube I10 and positioned around the guide wire I, a liquid inlet cavity communicated with the central channel I is arranged in the blood vessel bridge plug I and positioned around the guide wire I, and a liquid inlet communicated with one side of a blood return vein close to a tumor is arranged at the end part of the blood vessel bridge plug I;
the end part of the built-in tube 7 extending to the outside of the body is provided with a mounting hole for accommodating the insertion of the guide wire 6, and the side wall of the built-in tube 7 extending to the outside of the body is provided with a blood circulation joint 21 and an oxygen supply joint 22;
the end part of the built-in tube I extending to the outside of the body is provided with a mounting hole I for accommodating insertion of a guide wire I, and the side wall of the built-in tube I extending to the outside of the body is provided with a blood return circulation joint 23 and an oxygen supply joint I24;
the blood supply device further comprises an external blood supply machine 26, an external circulation pipeline 25 is arranged on the external blood supply machine 26, and two ends of the external circulation pipeline 25 are communicated with the blood supply circulation joint 21 and the blood return circulation joint 23.
In this embodiment, all be provided with seal wire and built-in pipe along tumour blood supply artery and back blood intravenous in the patient, built-in pipe tip sets up the blood vessel bridging plug, utilize the seal wire to put into built-in pipe and blood vessel bridging plug along the blood vessel and be close to tumour blood supply department, make the oxygen membrane bag inflation on the blood vessel bridging plug lateral wall through the injection oxygen pressurization, carry out embolism tumour blood supply aorta, utilize built-in pipe and blood vessel bridging plug to form the extracorporeal circulation pipeline at tumour blood supply back blood both ends, keep apart tumour blood supply blood return system alone, carry out the medicine treatment simultaneously and extracorporeal blood supply, avoid cancer cell metastasis, improve tumour medicine intervention treatment rehabilitation effect.
In a preferred embodiment, the guide wire 6 is set to be 0.8mm-1.2mm, the diameters of the built-in tube 7 and the built-in tube I10 are set to be 1.8-2mm, and the structure of the embodiment avoids thrombus and improves the interventional treatment efficiency.
In a preferred embodiment, the diameters of the blood vessel bridge plug 8 and the blood vessel bridge plug I11 are set to be 2-2.4mm, the end part of the other end of the blood vessel bridge plug 8, which is far away from the liquid outlet, is close to the edge, a conical surface is arranged, a blood supply hole 18 communicated with one end of the tumor blood supply aorta, which is far away from the tumor, is arranged on the conical surface, and a blood supply channel 17 communicated with the blood supply hole and the liquid outlet cavity is arranged on the blood vessel bridge plug, so that the blood vessel bridge plug 8 and the blood vessel bridge plug I11 can circulate blood at two sides of the blood vessel bridge plug 8 and the blood vessel bridge plug I11 before an embolic pipeline is not formed, and thrombus is avoided.
In a preferred embodiment, the inner tube 7 and the vascular bridge 8 are provided as an integral body, the vascular bridge is formed by laser processing of medical PC materials, and the structure is convenient for processing operation in the embodiment.
The medical oncology drug interventional therapy device of the embodiment performs interventional therapy training method under a transparent visual model as follows:
1) Constructing an interventional therapy training system: the interventional training system comprises an indwelling needle puncture kit and a puncture model, wherein,
the indwelling needle puncture kit comprises an indwelling needle, a guide wire and an indwelling tube;
the puncture model comprises a transparent simulation part for simulating tumor tissues, a vein tube for simulating vein vessels, a liquid supply box, an arterial tube for simulating vein vessels, a delivery pump for delivering simulated blood and a switch for controlling the start/stop of the delivery pump, wherein containers which are communicated with the vein tube and the arterial tube are arranged in the simulation part, and the container is used for tumor blood supply capillary vessels and normal blood supply capillary vessels.
2) Starting a delivery pump, so that simulated blood returns to the liquid supply box along the liquid supply box, the delivery pump, the arterial tube, the transparent simulation part and the venous tube, and setting the pressure of the arterial tube and the venous tube so as to simulate arterial pressure and veins;
3) Determining puncture points on arterial ducts and venous ducts, and sterilizing the puncture points;
4) On arterial and venous vessels; holding an indwelling needle in the puncture kit, performing puncture training according to the indwelling needle specification, and introducing a guide wire into the transparent simulation part to be positioned between a tumor blood-supply capillary and a normal blood-supply capillary;
5) Introducing an indwelling needle built-in tube between a tumor blood supply capillary and a normal blood supply capillary along a guide wire;
6) The external blood circulation joint and the return blood circulation joint of the built-in tube donors of the arterial tube and the venous tube are connected with a second circulation system, and the arterial tube and the venous tube are plugged by the vascular bridge plug and the vascular bridge plug I, so that internal circulation and external double circulation are realized.
In interventional therapy training of the interventional therapy device, the arterial tube and the venous tube are constructed in the puncture model, the venous tube passes through the simulation part, the purpose of simulating blood vessels can be achieved, the conveying pump and the container are constructed in the puncture model, the conveying pump, the arterial tube and the venous tube are communicated with the container, accordingly, a circulation channel for simulating blood can be established in the puncture model, the purpose of simulating blood flow in the blood vessels can be achieved, the puncture model and the puncture training method are enabled to be more vivid, the simulated blood in the arterial tube and the venous tube has certain pressure, the problem of simulating arterial blood and venous blood pressure can be solved, after the arterial tube and the venous tube are plugged by the vascular bridge plug I, internal and external double circulation of the transparent simulation part is achieved, different color liquids are added through the transparent simulation part, the change of the liquid color in the internal and external double circulation is observed, and the using state of the interventional therapy device for oncology medicine is mastered.
The medical oncology drug interventional therapy device of the embodiment performs interventional clinical therapy training under a mice experiment as follows:
1) Animals and groupings: randomly dividing 20 mice into an experimental group a (10) and a group b control group (10), and numbering and feeding;
2) And (3) establishing a model: taking tumor cells, washing the tumor cells with sterile physiological saline, properly diluting, adding 10 microliters of 0.4% phenol blue into 40 microliters of cell suspension, staining and microscopic examination and counting to obtain the tumor cell suspension with the concentration of 3 x 10 6 Tumor cell suspensions per ml, 0.1 ml of tumor cell suspension was inoculated at different sites of each 2 mice of the experimental group a (10) and the control group b (10), and the distribution thereof (1-2 cases of kidney, 3-4 cases of colon, 5-6 cases of uterus, 7-8 cases of abdomen and 9-10 cases of urethra);
3) Establishing an interventional therapy model: establishing a tumor drug interventional therapy device for mice in the experiment A group; forming an in-vivo and in-vitro double-circulation blood channel;
4) After inoculation, the inoculation part is observed daily for infection, and the tumor has natural regression after growth.
As a result, in the experimental process, the white mice die rapidly due to the thrombus arrival caused by the vascular bridge plug, wherein the tumor growth of the white mice in the experimental group a is obviously slower than that of the white mice in the control group b, thus adopting an in-vitro and in-vivo double-circulation blood channel, and the application of the drug intervention treatment in the extracorporeal circulation blood channel has obvious inhibition effect on the tumor growth and diffusion.
Finally, it is noted that the above-mentioned preferred embodiments are only intended to illustrate rather than limit the invention, and that, although the invention has been described in detail by means of the above-mentioned preferred embodiments, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the scope of the invention as defined by the appended claims.
Claims (5)
1. Medical oncology medicine intervenes treatment device, its characterized in that: comprises a guide wire extending into a tumor blood supply aorta, a built-in tube sleeved on the guide wire, a guide wire I extending into a tumor blood return vein and a built-in tube I sleeved on the guide wire I, wherein the ends of the built-in tube and the built-in tube I are respectively provided with a vascular bridge plug for embolizing the blood supply aorta and a vascular bridge plug I for embolizing the blood return vein, the outer walls of the vascular bridge plug and the vascular bridge plug I are respectively provided with a containing groove, an oxygen membrane bag for inflating oxygen is arranged in the containing groove,
a central channel is arranged in the built-in tube and around the guide wire, a liquid outlet cavity communicated with the central channel is arranged in the blood vessel bridge plug and around the guide wire, and a liquid outlet communicated with one side of the blood supply aorta close to the tumor is arranged at the end part of the blood vessel bridge plug;
a central channel I is arranged in the built-in tube I and around the guide wire I, a liquid inlet cavity communicated with the central channel I is arranged in the vessel bridge plug I and around the guide wire I, and a liquid inlet communicated with one side of a blood return vein close to a tumor is arranged at the end part of the vessel bridge plug I;
the end part of the built-in tube extending to the outside of the body is provided with a mounting hole for accommodating the insertion of a guide wire, and the side wall of the built-in tube extending to the outside of the body is provided with a blood circulation joint and an oxygen supply joint;
the end part of the built-in tube I extending to the outside of the body is provided with a mounting hole I for accommodating insertion of a guide wire I, and the side wall of the built-in tube I extending to the outside of the body is provided with a blood return circulation joint and an oxygen supply joint I;
the blood supply device also comprises an external blood supply machine, wherein an external circulation pipeline is arranged on the external blood supply machine, and two ends of the external circulation pipeline are communicated with a blood supply circulation joint and a blood return circulation joint.
2. The medical oncology drug intervention device of claim 2 wherein: the guide wire is arranged to be 0.8mm-1.2mm.
3. The medical oncology drug intervention device of claim 3 wherein: the diameters of the built-in pipe and the built-in pipe I are set to be 1.8-2mm.
4. The medical oncology drug intervention device of claim 1 wherein: the diameter of the blood vessel bridge plug and the diameter of the blood vessel bridge plug I are set to be 2-2.4mm, a conical surface is arranged on the blood vessel bridge plug, which is close to the edge, at the end part of the other end of the blood vessel bridge plug, which is far away from the liquid outlet, a blood supply hole communicated with one end of the tumor blood supply aorta, which is far away from the tumor, is arranged on the conical surface, and a blood supply channel which is communicated with the blood supply hole and the liquid outlet cavity is arranged on the blood vessel bridge plug.
5. The medical oncology drug intervention device of claim 1 wherein: the built-in tube and the vascular bridge plug are arranged as an integrated body, and the vascular bridge plug is formed by laser processing of medical PC materials.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311060236.XA CN117017400A (en) | 2023-08-22 | 2023-08-22 | Medical oncology medicine intervention treatment device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311060236.XA CN117017400A (en) | 2023-08-22 | 2023-08-22 | Medical oncology medicine intervention treatment device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117017400A true CN117017400A (en) | 2023-11-10 |
Family
ID=88635205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311060236.XA Withdrawn CN117017400A (en) | 2023-08-22 | 2023-08-22 | Medical oncology medicine intervention treatment device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117017400A (en) |
-
2023
- 2023-08-22 CN CN202311060236.XA patent/CN117017400A/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2868559B2 (en) | Retrograde perfusion treatment device | |
| JP2776526B2 (en) | Improved retroperfusion | |
| CN103961788B (en) | Occlusion perfusion catheter | |
| US4447236A (en) | Infusion catheter system | |
| JP4224608B2 (en) | Infusion therapy equipment | |
| MX2007008129A (en) | Retrograde perfusion of tumor sites. | |
| JP7280268B2 (en) | Procedure simulator | |
| JP2009034462A (en) | Perfusion system for therapy of pancreas | |
| JPH08508186A (en) | Balloon catheter and device for perfusion with balloon catheter | |
| CN209771078U (en) | drug delivery device | |
| CN106535785A (en) | Selectively delivering particles into the distal portion of the left gastric artery | |
| CN111330137A (en) | Drug delivery device | |
| CN209392017U (en) | Foley's tube and its system | |
| CN117017400A (en) | Medical oncology medicine intervention treatment device | |
| CN110251778A (en) | A kind of Internal Medicine-Oncology drug delivery device | |
| CN109124719A (en) | Foley's tube and its system | |
| CN210249997U (en) | Cyst puncture trocar | |
| CN112638460B (en) | Balloon within balloon catheter systems and methods of use | |
| CN203090200U (en) | Novel double-balloon catheter | |
| CN111569180A (en) | Disposable bladder perfusion apparatus | |
| CN218075915U (en) | Arterial perfusion chemoembolization structure | |
| CN220938760U (en) | Phototherapy balloon catheter system | |
| CN117179844B (en) | Device for blocking and treating vascular lesions and malignant tumors | |
| CN216908898U (en) | Multi-lumen microcatheter for drug delivery | |
| US20060015065A1 (en) | Method of drug perfusion in paraaortic lymph node tumors, sheath for inserting catheter, and oxygenated blood perfusion apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20231110 |