CN1169562C - Extenal use ointment for restoring period of knocks and falls - Google Patents

Extenal use ointment for restoring period of knocks and falls Download PDF

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CN1169562C
CN1169562C CNB021223424A CN02122342A CN1169562C CN 1169562 C CN1169562 C CN 1169562C CN B021223424 A CNB021223424 A CN B021223424A CN 02122342 A CN02122342 A CN 02122342A CN 1169562 C CN1169562 C CN 1169562C
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blood
soft tissue
herba
tissue injury
use ointment
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CN1426809A (en
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董裕国
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Abstract

The present invention relates to external use ointment for the restoring period of knocks and falls, which comprises the Chinese medicinal raw materials with the following proportion by weight: 400 to 600 of wooden root bark, 80 to 120 of Spica Prunellae, 8 to 12 of inula herb, 15 to 25 of climbing groundsel herb, 25 to 35 of frankincense, 25 to 35 of myrrh, 180 to 220 of safflower, 2500 to 3500 of vegetable oil, 900 to 1200 of lead oxide and 60 to 100 of Bengal water dropwort. The external use ointment aims at the old soft tissue injury, the stagnation of qi and the blood stasis, and has the functions for dredging channels, removing obstruction in collaterals, dispelling wind and eliminating dampness, so the external use ointment has the satisfactory effect for treating the old soft tissue injury.

Description

Be used for the convalescent externally applied ointment of traumatic injury
Technical field
The present invention relates to the analgesic solution (applies spirit) and the convalescent Wound healing paste (Caulis et Folium Pothi Repentis cream) at a kind of traumatic injury initial stage.
Technical background
At present, the Chinese medicine that is used for the traumatic injury treatment is a lot, has oral agents that external use liquid or unguentum are also arranged.Be seen in the more of report, but generally adopt a kind of prescription drug, lack specific aim interim of whole treatment.
Summary of the invention
The present invention seeks at different with the convalescent period in the early stage mechanism of traumatic injury, propose the analgesic solution (applies spirit) and the convalescent Wound healing paste (Caulis et Folium Pothi Repentis cream) at the initial stage that is applicable to respectively.
Prescription theory foundation of the present invention: (one) QI and blood and along being the basis (physiology) that body is kept normal physiological function:
1, " people's the owner, blood and gas ear ".QI and blood is to constitute human body, and keeps the most basic material of body vital functions." with transfer the five internal organs, spill old six internal organs, be can go into arteries and veins also.So follow about the arteries and veins, pass through the five internal organs, network six internal organs also ".Be that QI and blood can be irrigated the vital organs of the human body, warm whole body limbs moisten and support the extremity bones of the body collectively, flow round without stopping, to keep normal physiological function.
2, " qi warming body, blood nourishing " has only the vigorous tonneau of QI and blood just can give full play to it and limb muscles and bones warm moistened foster." the passages through which vital energy circulates person is so promoting the circulation of blood gas and seek negative and positive moistens muscles and bones, sharp joint person also ", " hereat vim and vigour and, then passages through which vital energy circulates is popular, the multiple negative and positive of battalion, powerful muscle and bone, the joint is clear sharp ".The activity of limbs joint be unable to do without the supply of QI and blood, positive what is called " all gas persons all belong to lung, the tide sunset of this extremity bones of the body collectively ... feet with sufficient blood can walk normally, the palm with sufficient blood can grip tightly, fingers with sufficient blood can work steadily ", be exactly this reason.In a word, all muscle muscles and bones all be unable to do without QI and blood nutrition, and the normal operation of QI and blood is the assurance of human body joint normal physiological activity.
(2) qi stagnation blood stasis is a soft tissue injury pathogenesis core (pathology):
1, with regard to soft tissue injury, qi depression to blood stasis is that wherein the pathology machine changes core.When limbs are subjected to the external force wound, local limbs flesh tendon damage, all can cause the meridian qi and blood dysfunction, produce a series of corresponding diseases.The QI and blood disorder is the inevitable outcome of soft tissue injury pathology.Gas-tight obstructed be for stagnating, blood from through or operation freely be not the stasis of blood.In the pathology and recovery from illness process of whole soft tissue injury, QI-blood circulation is nourished to change and is played crucial effects.Qi depression to blood stasis is present in the soft tissue injury course of disease all the time, is its pathogenesis core.
2, the soft tissue injury main clinical manifestation is pain, swelling, dysfunction.Point out in " interior warp " " impairment of QI resulting in pain, injury of configuration resulting in swelling ".The function of normal gas has the promotion excitation, " qi as the commander of blood ".Blood operation must have the promotion of gas.The logical dereliction of duty of injured then a surname of gas, obstructed and constipated still pain." stagnation of QI and blood may bring about pain " is the pathogenesis performance of impairment of QI.Shape is a parenchymal tissue, and soft tissue injury also comprises the destruction of form essence, and external force acts on the part, injures blood vessels, and sering is broken or block up stagnates, and blood is from warp, and building up does not loose forms swelling.Li Zhongzi's (bright) thinks: " a surname is logical in the gas happiness, and impairment of QI is then obstructed and constipated, so pain.Shape is that matter resembles, and shape is hindered then to delay and do not changed, so swollen ".Wu brings up logical (bright): say that " gas is invisible, death of illness pain; Blood is tangible, and death of illness is swollen.Local qi depression to blood stasis, passages through which vital energy circulates lose and support, obstacle also appears in trouble limb function thereupon.
3, local soft tissue is damaged, is injured QI and blood, and multipotency causes the dirty meridian qi and blood dysfunction of internal organs, produces the corresponding symptom of answering.Described in " roman class want ": " limb injury in outside, then QI and blood is hindered in interior, battalion defends does not to some extent pass through, function by discord ".Spell out local QI and blood and changed, further influenced the variation of function." vim and vigour discord, all kinds of diseases and ailments are change and give birth to " is exactly this reason.
4, soft tissue injury, qi depression to blood stasis, and then ((7) Chen Jianhong tries to make a comment that the wound blood stasis becomes numbness can to develop into numbness." Chinese bone injury " 1988.1 (3) .9)." interior warp. the numbness opinion " mention " and wet three gas of wind and cold are assorted extremely, close and be numbness also.Its migratory BI-syndrome caused mainly by pathogenic wind, BI-syndrome caused mainly by pathogenic cold being called painful BI, the dampness victor is an arthralgia caused mainly by damp ", study carefully its pathogenesis, not outer is that various pathogenic factor act on body, causes the disorder of passages through which vital energy circulates QI-blood circulation, the numbness resistance is obstructed, thereby causes a series of symptoms.So " doctor portion xerox " said: numbness person, to close also, pain is also.The wind-cold damp pathogen of diseases caused by exogenous pathogenic factor or interior life so so can close the yin channel arteries and veins, anemofrigid-damp arthralgia occurs, stops in the blood stasis that is caused by wound, and the gas defluidization is logical, more can block passages through which vital energy circulates, causes the QI and blood impatency and " the wound blood stasis becomes numbness " occur.Simultaneously, wound both can become numbness separately, also can with other paathogenic factors one body that works, cause arthromyodynia.Thereby cause the delay of the soft tissue injury course of disease.
(3) blood circulation promoting and blood stasis dispelling is the key (rule of treatment) of soft tissue injury treatment:
1, soft tissue injury and QI and blood, qi depression to blood stasis are its pathogenesis cores.The place one's entire reliance upon keeping of QI and blood of its recovery from illness process, and local stasis of blood stops amassing, the stagnation of QI is obstructed, obviously is unfavorable for the recovery of pathological changes.Thereby, at first should consider the keeping problem of vim and vigour for the treatment of soft tissue injury, to dredge dispelling stagnant Qi, dissipation blood stasis.The gas general rule not bitterly, the stasis of blood then pneumonedema of loosing, the vim and vigour smoothness, then muscles is moistened fosterly, the joint is sliding for it sharp, it is normal that limb function also recovers.
2, to the treatment of soft tissue injury, clinical not outer treatment by oral administration of medicines, external treatment two classes.Study carefully its pathogenesis, all cause the disorder of whole body QI and blood by local qi depression to blood stasis.Local QI and blood is unobstructed, and then the whole body QI and blood is also with suitable.So the treatment emphasis should be taken into account whole body improving local QI-blood circulation.Thereby external treatment has outside it original relatively.
3, in treatment to soft tissue injury, except blood circulation promoting and blood stasis dispelling, alleviating pain and detumescence and, more it should be noted that " the wound stasis of blood is because of becoming numbness ".The front was discussed, and wound both can become numbness separately, and easier closing with heresy rheumatism forms numbness.So in the middle of clinical treatment, except following the principle of " hard masses should be resolved gradually, disease with retention of pathogen in the body should be treated by elimination therapy ", and will note applying in a flexible way, adopt method eliminating evil or that set upright.
With regard to soft tissue injury, qi depression to blood stasis is that its pathology machine changes core.When limbs are subjected to the external force wound, local limbs flesh tendon damage all can consistent meridian qi and blood dysfunction, produces a series of corresponding symptoms.Gas-tight obstructed be for stagnating, blood from through or operation freely be not the stasis of blood.Gas-tight then pain, blood stasis is then swollen.In whole soft tissue injury pathology and recovery from illness process, QI-blood circulation is nourished to change and is played crucial effects.Thereby, should consider that at first QI and blood has the keeping problem for the treatment of soft tissue injury, to dredge dispelling stagnant Qi, dissipation blood stasis.Make the QI and blood smoothness, passages through which vital energy circulates is full, and muscles is supported, and the joint is sliding for it sharp, and it is normal that limb function also recovers.
The inventor finds out in long-term clinical practice, and for the treatment of soft tissue injury, key is early stage detumescence and pain relieving, and this is for the rehabilitation of pain and the generation of minimizing sequela, and is significant.Because traumatic injury is local injured, so employings distillate medicinal water is an excipient, help drug effect performance and easy to use, and the local skin absorption is rapider, act on more direct so that rapid alleviating pain and detumescence.At the pathogenic characteristic of acute soft tissue injury, serve as the main analgesic solution of forming with the flavour of a drug of blood circulation promoting and blood stasis dispelling, be used for the treatment of acute soft tissue injury, have tangible reducing swelling and alleviating pain effect.
Be used for traumatic injury initial stage analgesic analgesic solution (applies spirit) and form (weight ratio) by the volatile oil of following component:
Subdigitate wormwood herb 400~600 Herba Taraxacis 400~600 Cortex araliae chinensis root bark 1500~2500
Herba Senecionis Scandentis 800~1200 Herba Inulae 40~60 Herba Apiis 60~100
Main Ingredients and Appearance pharmacology and compatibility in the above-mentioned prescription are described as follows:
One, pharmacology:
Medicine name effect modern pharmacology
Subdigitate wormwood herb inrigorating qi and promoting blood circulation, channels sootheing and network vessel quickening analgesia, antiinflammatory action
Cortex araliae chinensis root bark dissipating blood stasis blood, detumescence poison, damp eliminating, analgesia, antihistamine, blood vessel dilating are done
Diuresis is used
Herba Senecionis Scandentis heat-clearing and toxic substances removing, the parasite killing broad-spectrum antibacterial action that makes eye bright
The Herba Apii suppressing the hyperactive liver, induce sweat, rash antiinflammatory, analgesic, diuresis
Two, compatibility mechanism:
The pathogenesis core of acute soft tissue injury is a qi depression to blood stasis, the place one's entire reliance upon keeping of QI and blood of its recovery from illness process.And local stasis of blood stops amassing, and the stagnation of QI obviously is unfavorable for the recovery of pathological changes for logical.Because to its treatment, to dredge dispelling stagnant Qi, the dissipation blood stasis is main.One applies clever analgesic solution with Cortex araliae chinensis root bark blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, is monarch drug.With the detumescence of subdigitate wormwood herb stasis-dispelling and pain-killing, principal drug assistance is ministerial drug to reach the merit of mediation dissipation; With Herba Apii, the pain relieving of Herba Senecionis Scandentis promoting blood circulation and detumescence, be adjuvant drug altogether.All medicines share, and gather blood circulation promoting and blood stasis dispelling altogether, the effect of reducing swelling and alleviating pain.Dosage form design is the external distillate medicinal water, is the power of the getting it filled focus of going directly rapidly, adapts to the pathogenic characteristic of acute soft tissue injury.
Three, preparation technology:
(1) clean weighing:
Six-element medical herbs such as subdigitate wormwood herb are all gathered by the said preparation conventional criteria, remove impurity, eluriate totally, cut the 2-3CM section, and are by the flavor weighing, standby.
(2) extract:
1, distillation:
Except that the Cortex araliae chinensis root bark, all the other five tastes place altogether and add water in the distillation in right amount, adopt hydrodistillation altogether, add thermal distillation, collect distillate 2000ml, and are standby.This is a first liquid.
2, decocting and concentrating:
The five tastes such as subdigitate wormwood herb after distillation add into the Cortex araliae chinensis root bark, decoct with water twice, and back 30-60 minute of at every turn boiling filters, the medicinal residues squeezing, and filtrate merges with pressed liquor, and water-bath is concentrated, add 1% active carbon boiling decoloring filter the 500ml medicinal liquid, this is a second liquid.
(3) dosing fill:
Get first liquid and second liquid and merge mixing, embedding 500ml or 250ml.
(4) check packing:
100 ℃, 30 minutes circulation steams, quality inspection, labeling are packed promptly.
Acute soft tissue injury easily forms local stagnation of QI-blood in convalescent period, and the existence that the stasis of blood stagnates not only makes the local coagulation of QI-blood of damage, space between skin and muscles is empty, defends outer function generation obstacle, and wind-cold damp pathogen can be attacked in an opponent's defence, is detained meridians, develop into numbness, with the rich mutually knot of QI and blood that the stasis of blood stagnates, making falls ill decreases touching difficulty more.Thereby, should improve the keeping of local QI and blood on the one hand for its treatment, to dredge dispelling stagnant Qi, the dissipation blood stasis is main; Should adopt channels sootheing and network vessel quickening according to the pain machine characteristics of the different courses of disease on the other hand, the method for expelling wind and removing dampness makes the QI and blood smoothness, and passages through which vital energy circulates is full, and muscles is moistened foster, defends outer function and recovers normal, and exopathogen is removed.
Wound healing paste (Caulis et Folium Pothi Repentis cream) is at old soft tissue injury qi depression to blood stasis, the meridian dredging that relaxes of holding concurrently again, and expelling wind and removing dampness, thereby be used for the treatment of old soft tissue injury, effect is satisfied.
Be used for the convalescent Wound healing paste of traumatic injury (Caulis et Folium Pothi Repentis cream) and constitute (weight ratio) by following component:
Cortex araliae chinensis root bark (Caulis et Folium Pothi Repentis cream) 400~600 Herba Inulae 8~12
Spica Prunellae 80~120 Herba Senecionis Scandentiss 15~25 Olibanums 25~35
Myrrha 25~36 Flos Carthamis 180~220 vegetable oil 2500~3500
Lead orthoplumbate 900~1200 Herba Apiis 60~100.
Its pharmacology of each component and compatibility mechanism in the said components are described as follows:
One, pharmacology:
Medicine name function modern pharmacology
Caulis et Folium Pothi Repentis dissipating blood stasis for subsidence of swelling, expelling wind and removing dampness analgesia, antihistamine, blood vessel dilating effect
Subdigitate wormwood herb inrigorating qi and promoting blood circulation, channels sootheing and network vessel quickening analgesia, antiinflammatory action
Olibanum is invigorated blood circulation and is stretched muscle pain relieving, detumescence and promoting granulation analgesia, antiinflammatory action
The analgesia of Myrrha promoting blood circulation, removing blood stasis and relieving pain, antiinflammatory action
Herba Senecionis Scandentis heat-clearing and toxic substances removing, the parasite killing broad-spectrum antibacterial action that makes eye bright
Two, compatibility mechanism:
Acute soft tissue is lost in treatment, and the course of disease is delayed, and then reports to be the old soft tissue injury.This moment since local stagnation of QI-blood with the passing of time, the meridians impatency is obstructed, muscles loses in moistening foster, very easily directly or have a cold damp and hot heresy and develop into numbness.Thereby to its treatment except blood circulation promoting and blood stasis dispelling, also should correspondingly adopt channels sootheing and network vessel quickening, the method for expelling wind and removing dampness.Caulis et Folium Pothi Repentis cream is monarch drug with Caulis et Folium Pothi Repentis blood circulation promoting and blood stasis dispelling, expelling wind and removing dampness, with Olibanum, Myrrha blood circulation promoting and blood stasis dispelling, the subdigitate wormwood herb channels sootheing and network vessel quickening, Herba Apii promoting blood circulation and detumescence dampness removing, principal drug assistance is with promoting blood circulation to remove obstruction in the collateral, and expelling wind and removing dampness is ministerial drug altogether, Herba Senecionis Scandentis, the medicine-feeding of Spica Prunellae association are adjuvant drug with mass dissipating and swelling eliminating altogether.All medicines share, and gather the effect of blood circulation promoting and blood stasis dispelling, channels sootheing and network vessel quickening, expelling wind and removing dampness altogether.Dosage form design is an external-use ointment, is longer at the old soft tissue injury course of disease, and the characteristics that patient's condition is touching make the efficacy of a drug relax performance enduringly, to reach the merit that promoting blood circulation to remove obstruction in the collateral reaches heresy.
Three, preparation technology:
(1) selection of base starting material and spice are handled
1, material choice:
(1) vegetable oil: take by weighing commercially available vegetable oil 3000g.
(2) Plumbum preparatium: take by weighing purity 98% above lead orthoplumbate 900-1260g, fry and do, cross the 80-100 mesh sieve, place dry place, standby.
2, spice is handled:
By said preparation standard acquisition Herba Inulae, Herba Senecionis Scandentis, Spica Prunellae, subdigitate wormwood herb, Herba Apii, Caulis et Folium Pothi Repentis and be cut into segment, the weighing of fortune flavor.Get Olibanum, Myrrha is ground into fine powder, and is standby.
(2) preparation:
1, the extraction of spice (enduring withered removing slag):
Get vegetable oil and put in the pot, blow up a day Rhizoma cypripedii macranthi after the slight fever earlier, treat friedly after withered and yellow, descend surplus medicines such as Herba Inulae again, constantly stir, fried to surperficial dark brown inside when sallow until spice, raise with iron wire and to drag for medicinal residues, leave and take medicine oil.
2, oil refining:
Get above-mentioned medicine oil, continue to temper, treat that oily temperature rises to 320-330 ℃ and uses moderate heat instead, and the oil of constantly raising, when waiting oil refining oil smoke, oil bloom to occur and drip into pearl.
3, pilling and pasting:
The medicine oil that refining is good connects pot and is put in steady place from fire, adds lead orthoplumbate Plumbum preparatium, and spreading is even, maintenance speed, and ceaselessly equidirectional stirring, in case the heavy poly-the bottom of a pan of Plumbum preparatium treats that white cigarette emits to the greatest extent, temperature is declined to become the thick plaster of pitchy.
4, remove " fire-toxin ":
Above-mentioned plaster is blown slowly in the impouring water, constantly stir, constantly change cooling water, wait and take out pressure-raising repeatedly after condensing, and make agglomerate, be dipped in 5-7 day in the cold water, change water every day once with wooden stick.
5, the stand is coated with:
Get the plaster agglomerate and put in the water-bath and melt, be blended into Olibanum, Myrrha fines, stir evenly, pick a certain amount of plaster (about 4.5g) stand with bamboo let and be applied on the clothed mounting.
(3) check packing:
Check coating weight difference limit, appearance character.Labeling, packing, seasoning.
One applies clever analgesic solution and Caulis et Folium Pothi Repentis Wound healing paste respectively at the pathogenic characteristic of the different courses of disease of soft tissue injury, based on the medicine of blood circulation promoting and blood stasis dispelling, hold concurrently with channels sootheing and network vessel quickening, expelling wind and removing dampness, the product of the strong muscle of QI invigorating, prescription is rigorous, and compatibility is precise and appropriate, thereby soft tissue injury there is better curative effect, compare with the similar medicine of present clinical use, it is fast to have produce effects, makes the characteristics of making good use of.Its dosage form is an external preparation, and is easy to use, safe, have no side effect.
The present invention proves this product steady quality through stability test and skin allergy test, and skin is not had part and systemic anaphylaxis.The institute for drug control, Baoji proves up to specification by standard test simultaneously.(seeing Appendix 1)
The present invention treats soft tissue injury and observes treatment 573 routine patients through Feng County institute of traditional Chinese medicine, 152 routine patients are organized in the treatment of contrast ZHENGHONGHUA YOU, clinical observation result shows that a deposited clever analgesic solution was used for the acute soft tissue injury average cure time 4.77 days, total effective rate 99%, cure rate is 93%, effect really, and is evident in efficacy, obviously is better than the control drug ZHENGHONGHUA YOU.Show that the Caulis et Folium Pothi Repentis Wound healing paste is used for the treatment of the recovery of old soft tissue injury, total effective rate 94%, cure rate are 62%, and effect really, and is evident in efficacy.(seeing Appendix 2)
Embodiment 1: be used for traumatic injury initial stage analgesic solution (applies spirit) and consist of: subdigitate wormwood herb 500g, Herba Taraxaci 500g, Cortex araliae chinensis root bark 2000g, Herba Senecionis Scandentis 1000g, Herba Inulae 50g.
Preparation method: with above-mentioned subdigitate wormwood herb, Herba Taraxaci, Herba Senecionis Scandentis, Herba Inulae, Herba Apii mixing and water adding distillation extraction, collect distillate 2000ml, collect aforementioned medicinal residues and Cortex araliae chinensis root bark and merge decocting 2 times, each 1 hour, add 1% activated carbon decolorizing and filter to such an extent that 500ml and front distillate merge through sterilization promptly.
Being used for the convalescent Wound healing paste of traumatic injury (Caulis et Folium Pothi Repentis cream) consists of: Cortex araliae chinensis root bark 500g, Herba Inulae 10g, Spica Prunellae 100g, Herba Senecionis Scandentis 20g, Olibanum 30g, Myrrha 30g, Flos Carthami 200g, Herba Apii 100g.
Preparation method:
Vegetable oil 3000g is heated to 200-220 ℃; add into the Cortex araliae chinensis root bark fried to withered and yellow, constantly stir after adding Herba Inulae, Herba Apii, Spica Prunellae, Herba Senecionis Scandentis, Flos Carthami again, fried drag for medicinal residues after sallow to spice, medicine oil continues to temper, rise to 320-330 ℃ and add lead tetroxide when using moderate heat to 360 ℃ instead and become paste etc. oily temperature, be blended into the stand behind Olibanum, the Myrrha porphyrize and be coated with promptly.
Embodiment 2: analgesic solution is formed:
Subdigitate wormwood herb 600g, Herba Taraxaci 400g, Aralia root veneer 1500g, Herba Senecionis Scandentis 1200g, Herba Inulae 40g, Herba Apii 60g.
Wound healing paste is formed:
Aralia root veneer 500g, Herba Senecionis Scandentis 20g, Herba Inulae 10g, Spica Prunellae 100g, Olibanum 30g, Myrrha 30g, Flos Carthami 200g, Herba Apii 60g.
Preparation method is all identical with example 1.
Embodiment 3: analgesic solution is formed:
Subdigitate wormwood herb 400g, Herba Taraxaci 600g, Aralia root veneer 2500g, Herba Senecionis Scandentis 800g, Herba Inulae 60g, Herba Apii 90g.
Wound healing paste is formed:
Aralia root veneer 400g, Herba Senecionis Scandentis 25g, Herba Inulae 8g, Spica Prunellae 80g, Olibanum 35g, Myrrha 35g, Flos Carthami 220g, Herba Apii 70g.
Preparation method is with embodiment 1.

Claims (1)

1, a kind of convalescent externally applied ointment of traumatic injury that is used for is characterized in that being made by following Chinese medicinal raw materials in proportion by weight:
Figure C021223420002C1
Wood root bark 400~600, Spica Prunellae 80~120, Herba Inulae 8~12,
Herba Senecionis Scandentis 15~25, Olibanum 25~35, Myrrha 25~35,
Flos Carthami 180~220, vegetable oil 2500~3500, lead orthoplumbate 900~1200,
Herba Apii 60~100.
CNB021223424A 1999-05-14 1999-05-14 Extenal use ointment for restoring period of knocks and falls Expired - Fee Related CN1169562C (en)

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Application Number Priority Date Filing Date Title
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Related Parent Applications (1)

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CN99115779A Division CN1096276C (en) 1999-05-14 1999-05-14 Antalgic liquid for early stage of bone fracture and injury and ointment for its recovery stage

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CN1169562C true CN1169562C (en) 2004-10-06

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CN104997919A (en) * 2015-08-24 2015-10-28 陕西绿色医疗科技有限公司 Plaster for treating qi-stagnation and blood stasis

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