CN116942550A - Cleaning composition and preparation method and application thereof - Google Patents

Cleaning composition and preparation method and application thereof Download PDF

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Publication number
CN116942550A
CN116942550A CN202310938216.1A CN202310938216A CN116942550A CN 116942550 A CN116942550 A CN 116942550A CN 202310938216 A CN202310938216 A CN 202310938216A CN 116942550 A CN116942550 A CN 116942550A
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CN
China
Prior art keywords
cleaning composition
amino acid
cleaning
foaming agent
taurine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202310938216.1A
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Chinese (zh)
Inventor
薛凯
邓洪英
吴东旭
冉佳艳
史权
王小兰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Dongli Great Health Research Institute Co ltd
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Shanghai Dongli Great Health Research Institute Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Shanghai Dongli Great Health Research Institute Co ltd filed Critical Shanghai Dongli Great Health Research Institute Co ltd
Priority to CN202310938216.1A priority Critical patent/CN116942550A/en
Publication of CN116942550A publication Critical patent/CN116942550A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00Anti-perspirants or body deodorants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005Antimicrobial preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

The invention relates to the technical field of cleaning agents, and particularly discloses a cleaning composition, a preparation method and application thereof. The cleaning composition of the present invention comprises: water, primary foaming agent, secondary foaming agent, chelating agent, bactericide, taurine and pH regulator; the bactericide is lauroyl arginine ethyl ester hydrochloride, and the mass ratio of the bactericide to the taurine is 1: (5-6). The invention discovers that taurine is a small molecular amino acid, can reduce the irritation of amino acid type bactericides, and further can be applied to cleaning female private parts related to mucous membrane tissues when the prepared composition contains the amino acid type bactericides.

Description

Cleaning composition and preparation method and application thereof
Technical Field
The invention relates to the technical field of personal care detergents, in particular to a cleaning composition, a preparation method and application thereof.
Background
The perineum of female has special structure, the skin is tender and involves the vulva, and microorganisms are easy to breed. It is therefore desirable that the private parts cleaning products must be mild and have an antibacterial or bacteriostatic effect.
Many private cleaning mousses on the market are compounded by using sodium (or ammonium) laureth sulfate and cocamidopropyl betaine with low content as foaming agents, and although the cleaning force is enough, the cleaning force cannot prove to be mild to the skin or vulva of sensitive parts, and bactericides such as triclosan or triclocarban contained in the cleaning mousse have cancerogenic risks and have been phased out. Other products also use chlorhexidine acetate or polyhexamethylene biguanide hydrochloride as bactericides, but they are chemically synthesized bactericides, and although the sterilizing effect is excellent, the safety of the bactericides is always subject to consumer problems, and meanwhile, the bactericides belong to cationic bactericides and cannot be compounded with high-foam anionic surfactants such as sodium laureth sulfate, so that the foaming performance of the product is poor. In addition, various plant extracts are declared to be used as bacteriostats, but in practice, the bacteriostats are not ideal, and the plant extracts often have color or unpleasant smell, have complex components and seriously affect the stability of the products, so the plant extracts are often used as conceptual additives, the addition amount is not more than 0.2%, and the sterilization effect still needs to be represented by chemical synthesized bactericides, such as triclosan and the like.
Therefore, further research into a mild and effective cleaning and sterilizing product is necessary.
Disclosure of Invention
One of the purposes of the invention is to provide a cleaning product with mild cleaning, bacteriostasis and peculiar smell removal.
In order to achieve the object, the technical scheme of the invention is as follows:
the present invention provides a cleaning composition comprising: water, primary foaming agent, secondary foaming agent, chelating agent, bactericide, taurine and pH regulator; the bactericide is lauroyl arginine ethyl ester hydrochloride, and the mass ratio of the bactericide to the taurine is 1: (5-6), preferably 1: (5.1-5.2).
The research of the invention finds that lauroyl arginine ethyl ester hydrochloride is an amino acid type bactericide, is an arginine derivative, has good antibacterial effect on staphylococcus aureus and candida albicans, but has strong irritation under the effective addition amount, and can not be independently used as an ideal bactericide to be applied to cleaning compositions with mild use effects.
Therefore, the invention is greatly researched, and the prior art discloses a method for reducing the irritation of the formula as a whole by compounding an amino acid type surfactant with milder properties, namely, sodium methyl cocoyl taurate, with other surfactants, so that the addition amount of the other surfactants is reduced. However, when other surfactants in the formulation are milder than sodium methyl cocoyl taurate, the effect of the addition of sodium methyl cocoyl taurate to reduce irritation is lost. And the method cannot reduce the irritation of the amino acid type bactericide, namely lauroyl arginine ethyl ester hydrochloride.
Through further research, the invention discovers that when the taurine which is a small molecular amino acid with a specific proportion is added into the formula, the irritation of the lauroyl arginine ethyl ester hydrochloride is unexpectedly greatly reduced, so that the formula is still moderate in whole under the condition of adding an effective amount, the application of the lauroyl arginine ethyl ester hydrochloride in cleaning tissues which are particularly sensitive to irritation (such as the skin and the vulva of female perineum parts) is suitable, and the application field of the lauroyl arginine ethyl ester hydrochloride is expanded.
The effect of reducing the irritation of the cleaning composition is reduced if the amount of taurine added is reduced, and if the amount is increased, the cost is adversely reduced.
In the cleaning composition of the invention, the primary foaming agent is sodium lauroyl oat amino acid and/or sodium cocoyl malate, and the secondary foaming agent is potassium cocoyl hydrolyzed oat protein; the mass ratio of the primary foaming agent to the secondary foaming agent is (1.2-3): 1, preferably 2.5:1.
The primary and secondary foaming agents used in the present invention are mild to the skin and eyes and are suitable for use in cleansers that may contact mucosal tissue. In addition, the main foaming agent and the secondary foaming agent are properly mixed, so that the cleaning force, the mildness and the foam effect can be simultaneously achieved. If the ratio of the two is 9:1, the product viscosity is low, and the foam is sparse and not dense. When the ratio of the two is 1:1, the viscosity of the product is too high, the foam state is not ideal, the production and the use are inconvenient, and the body feeling is uncomfortable.
In the cleaning composition of the present invention, the chelating agent is tetrasodium glutamate diacetate; the pH regulator is glutamic acid.
The chelating agent used in the invention is amino acid type chelating agent, and can be synergistic and antiseptic.
All active components of the invention are amino acid or derivatives thereof, so that consumers can more easily identify the identity of the amino acid type lotion, and the lotion has no stimulation to human skin and eyes after being integrally matched, has slight stimulation to mucous membrane tissues, and is suitable for daily cleaning of skin and vulva of female perineum parts.
The cleaning composition of the present invention comprises: 2% -3% of lauroyl oat amino acid sodium and/or 2% -3% of cocoyl apple amino acid sodium, 1.8% -2.2% of cocoyl hydrolyzed oat protein potassium, 0.05% -0.08% of tetra sodium glutamate diacetate, 0.3% -0.4% of lauroyl arginine ethyl ester hydrochloride, 1.5% -2% of taurine, 0.1% -0.2% of glutamic acid and the balance of water.
Preferably, the cleaning composition of the present invention comprises: 2.5% of lauroyl oat amino acid sodium and/or 2.5% of cocoyl apple amino acid sodium, 2.0% of cocoyl hydrolyzed oat protein potassium, 0.06-0.062% of tetra sodium glutamate diacetate, 0.35% of lauroyl arginine ethyl ester hydrochloride, 1.8% of taurine, 0.16% of glutamic acid and the balance of water.
The invention combines the cleaning effect, foaming effect, bacteriostasis effect, moisturizing effect and cost of the composition through a reasonable formula.
The composition obtained by the invention has the appearance: clear transparent liquid, no viscosity. Can be matched with a mousse foaming bottle to produce abundant foam; pH (direct assay): 5.0-5.5; stability: 45+/-1 ℃ for 24 hours, and recovering the room temperature to be normal; -5+/-2 ℃ for 24 hours, and recovering the room temperature to be normal.
The invention also provides a method for preparing the cleaning composition, which comprises the steps of mixing all components except the pH regulator and then adding the pH regulator.
The invention further provides an application of the cleaning composition or the cleaning composition prepared by the method in cleaning female private parts.
The invention further provides a female private parts cleaning mousse comprising a mousse foam bottle and a cleaning composition, the cleaning composition being disposed in the mousse foam bottle, the cleaning composition being as described above or prepared by the method described above.
The invention has the advantages that:
the invention provides a cleaning composition based on amino acid or derivatives thereof, which successfully applies an amino acid type bactericide with good antibacterial effect and strong irritation to the cleaning composition which needs a particularly mild effect, and the obtained cleaning composition has mild overall, good cleaning antibacterial effect and abundant foam, and is suitable for cleaning private parts of women.
Detailed Description
Preferred embodiments of the present invention will be described in detail below with reference to examples. It is to be understood that the following examples are given for illustrative purposes only and are not intended to limit the scope of the present invention. Various modifications and alterations of this invention may be made by those skilled in the art without departing from the spirit and scope of this invention.
The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials, reagents and the like used in the examples below, unless otherwise indicated, are all those available commercially or may be prepared by methods conventional in the art.
The sodium lauroyl oat amino acid used in the specific embodiment part of the invention is 20% sodium lauroyl oat amino acid aqueous solution, 20% sodium cocoyl malate aqueous solution, 30% potassium cocoyl hydrolyzed oat protein aqueous solution, 47% tetra sodium glutamate diacetate aqueous solution, and 20% ethyl lauroyl arginine hydrochloride.
Examples 1 to 3
This example provides cleaning compositions, with the following materials in mass percent as shown in table 1.
TABLE 1
The preparation method comprises the following steps:
at normal temperature, adding metering water into a stirring kettle, adding No. 1-6 raw materials according to the sequence of the raw materials in the formula, stirring at 30-50rpm for 10 minutes, and finally adding the formula amount of glutamic acid to adjust the pH value, and filtering and discharging.
Comparative example 1
This comparative example provides a cleaning composition having a formulation substantially the same as example 1, except that sodium methyl cocoyl taurate was used in place of taurine in the same amount.
Comparative example 2
This comparative example provides a cleaning composition having a formulation substantially the same as example 1, except that sodium methyl lauroyl taurate was used in place of taurine in the same amount.
Experimental example
This experimental example tests the performance of the cleaning compositions prepared in the above examples and comparative examples. The method comprises the following steps:
1. toxicology and bacteriostasis test: reference is made to the method described in the 2002 edition of the disinfection specification.
2. Irritation test: adopting a zein method, specifically taking 10ml of cleaning composition, diluting one time, dividing the cleaning composition into two parts, adding 0.5g zein into one part, stirring for 2 hours at 25 ℃, then filtering, and measuring the mass fraction of nitrogen of the filtrate by adopting a micro Kjeldahl nitrogen determination method to be A; another cleaning composition without Zein was measured by the same method for nitrogen mass fraction B, a-b=zein value, and the level of Zein value was used to obtain the irritation intensity of the cleaning composition.
3. Foam effect test: 10ml of a standard hard water-formulated 0.1% cleaning composition was added to a 100ml stoppered cylinder, shaken 30 times, and after standing for 1 minute, the foam height was measured.
4. Cleaning force test: referring to the test method of detergency in GB/T1224-2012 liquid detergent for clothing, the test concentration is 0.2%, and the cleaning force on JB-03 sebum dirt cloth is required to be larger than or equal to that of a standard laundry detergent.
The results of each set of tests are shown in Table 2 below.
TABLE 2
While the invention has been described in detail in the foregoing general description and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.

Claims (8)

1. A cleaning composition comprising: water, primary foaming agent, secondary foaming agent, chelating agent, bactericide, taurine and pH regulator; the bactericide is lauroyl arginine ethyl ester hydrochloride, and the mass ratio of the bactericide to the taurine is 1: (5-6).
2. The cleaning composition of claim 1, wherein the primary foaming agent is sodium lauroyl oat amino acid and/or sodium cocoyl malate and the secondary foaming agent is potassium cocoyl hydrolyzed oat protein; the mass ratio of the primary foaming agent to the secondary foaming agent is (1.2-3): 1.
3. the cleaning composition of claim 2 wherein the chelating agent is tetrasodium glutamate diacetate; the pH regulator is glutamic acid.
4. A cleaning composition according to any one of claims 1 to 3, comprising: 2% -3% of lauroyl oat amino acid sodium and/or 2% -3% of cocoyl apple amino acid sodium, 1.8% -2.2% of cocoyl hydrolyzed oat protein potassium, 0.05% -0.08% of tetra sodium glutamate diacetate, 0.3% -0.4% of lauroyl arginine ethyl ester hydrochloride, 1.5% -2% of taurine, 0.1% -0.2% of glutamic acid and the balance of water.
5. The cleaning composition of claim 4, comprising: 2.5% of lauroyl oat amino acid sodium and/or 2.5% of cocoyl apple amino acid sodium, 2.0% of cocoyl hydrolyzed oat protein potassium, 0.06-0.062% of tetra sodium glutamate diacetate, 0.35% of lauroyl arginine ethyl ester hydrochloride, 1.8% of taurine, 0.16% of glutamic acid and the balance of water.
6. A process for preparing a cleaning composition according to any one of claims 1 to 5, wherein the pH adjuster is added after mixing the components other than the pH adjuster.
7. Use of a cleaning composition according to any one of claims 1 to 5 or a cleaning composition prepared by a process according to claim 6 for cleaning female private parts.
8. A female private cleaning mousse comprising a mousse foam bottle and a cleaning composition disposed in the mousse foam bottle, the cleaning composition being as claimed in any one of claims 1 to 5 or produced by the method of claim 6.
CN202310938216.1A 2023-07-28 2023-07-28 Cleaning composition and preparation method and application thereof Pending CN116942550A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310938216.1A CN116942550A (en) 2023-07-28 2023-07-28 Cleaning composition and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202310938216.1A CN116942550A (en) 2023-07-28 2023-07-28 Cleaning composition and preparation method and application thereof

Publications (1)

Publication Number Publication Date
CN116942550A true CN116942550A (en) 2023-10-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN202310938216.1A Pending CN116942550A (en) 2023-07-28 2023-07-28 Cleaning composition and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN116942550A (en)

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