CN116935950A - Intelligent integrated management system of accurate medical molecular genetic laboratory - Google Patents

Abstract

The invention discloses an intelligent comprehensive management system of an accurate medical molecular genetic laboratory, which comprises the following components: the system comprises an application layer, a service layer and an infrastructure layer, wherein the application layer provides management operation and system management operation of specific application services; the service layer provides a background service operation interface entry and related function management services; the infrastructure layer provides computing, storage resources, and a network environment. The intelligent comprehensive management system of the precise medical molecular genetic laboratory has the following advantages: a comprehensive professional data platform is established as an infrastructure, clinical data and histology data are effectively integrated, a multi-level biomedical data system is formed, high-level scientific research and clinical application of accurate medicine are supported, and standard standards are established.

Description

Intelligent integrated management system of accurate medical molecular genetic laboratory

Technical Field

The invention relates to the technical field of laboratory management, in particular to an intelligent comprehensive management system of an accurate medical molecular genetic laboratory.

Background

Constructing a safe, stable, efficient, open and easy-to-use clinical data infrastructure by utilizing an advanced data technology, and constructing an international advanced and clinical scientific research collaborative precision medical molecular laboratory information management platform; forming a set of complete histology data management standard, clinical gene detection experiment standard and clinical data application and development standard in the field of accurate medical molecular experiments; supports the scientific research collaboration of clinical big data and promotes the conversion of scientific research results into accurate medical clinical application.

At present, the Chinese molecular diagnosis industry has fast development, more samples of a clinical laboratory and good benefit, but the problems accompanying the Chinese molecular diagnosis industry include difficult sample searching, difficult file storage, difficult data searching and the like, and clinicians, patients, inspection laboratories and genetics specialists may need to search data and information in a plurality of systems, for example, an HIS system only records registration information, does not have family information and family sample management, an LIS system only reflects detection results, does not detect SOP, reports a multistage audit management flow and the like, which causes the problem of data information island, increases workload, and is slow in communication, and the relationship between doctors and patients is tense.

At present, an HIS system or an LIS system is adopted in a medical molecular genetic laboratory, and the HIS system has the defect of recording only aiming at registration information, and does not have family information and family sample management. The LIS system has the defects of only embodying detection results, no detection SOP and reporting a multi-level auditing management flow.

Disclosure of Invention

The LIMS system is based on webpage development, can integrate information of doctors, patients, inspection laboratories and genetics specialists in series, standardizes sample collection, detection flow, experimental operation and report writing, intelligently calls historical family detection information, intelligent reference of the same site historical report and the like, effectively reduces the problem of low information utilization value caused by information island, can realize professional management of the whole life cycle of the patient family sample, and improves service standardization, collaborative efficiency, data safety and common building sharing of professional knowledge.

In order to achieve the above object, the present invention provides an intelligent integrated management system for an excimer genetic laboratory, comprising:

the application layer provides management operation and system management operation of specific application services;

the service layer provides a background service operation interface entry and related function management services;

an infrastructure layer providing computing, storage resources, and a network environment, wherein:

the intelligent comprehensive management system of the precise medical molecular genetic laboratory specifically comprises:

the user management module is used for managing the user information on line;

the permission management module isolates and manages permissions of users for accessing various resources;

the detection management module is used for carrying out online management on the gene detection application form of the detected person;

the sample library management module is used for managing the experimental samples on line;

the experiment task management module is used for managing experiment tasks, experiment steps, experiment quality control and experiment result information on line;

the gene data management module provides a safe and effective storage environment for gene data, clinical phenotype information and experimental information;

a phenotype data management module for querying each other for HPO phenotype information and genotype information;

the analysis tool management module provides a storage environment for using tools in gene analysis and provides basic services for construction of an analysis flow; the online and visual operation and the test of the analysis tool are supported;

an analysis flow management module providing a workflow management page supporting a biological information manager to manage and run a workflow in a graphical manner;

the task management module is used for managing all task names, task creation time, task current states, row parameters, operation logs and result reports;

the report management module is used for online management of detection result reports of report writers, auditors and issuers;

the statistical analysis module is used for statistics and analysis of service data;

the knowledge base module is used for carrying out online management on the gene information and providing a knowledge framework by taking diseases as topics;

and the in-hospital system docking module is used for docking with the in-hospital HIS, LIS, PACS and electronic medical record systems, capturing data by combining with actual business scenes of the molecular laboratory and storing related electronic medical record information.

In a preferred embodiment of the present invention, the online management of the user information by the user management module is specifically: the login information of the common user is initialized online by a system administrator; the system administrator is realized to configure user authority information and reset login passwords on line; the basic information of the account number is maintained by the common user.

In a preferred embodiment of the present invention, each type of resource in the rights management module includes one or a combination of any two or more of account number, subject information, detection result, detection report, and sample information.

In a preferred embodiment of the present invention, the on-line management of the gene detection application form of the subject by the detection management module specifically includes: when a sample manager of a laboratory receives a paper detection application form and a physical sample of a testee meeting the initial examination requirement of the laboratory offline, the beginning of a laboratory business process is symbolized; laboratory personnel can check and monitor basic information of a subject detection application, the progress condition of an experiment task and the report progress condition of a detection result through detection management.

In a preferred embodiment of the present invention, the on-line management of the experimental samples by the sample library management module is specifically: the system function is combined with the laboratory offline business operation to complete the pretreatment of samples and the management of laboratory samples in and out of warehouse; when the sample manager registers sample information, the system supports automatic generation of sample numbers according to the coding rules of the molecular diagnosis center, and is connected with a printer in a butting mode, so that printing of the sample numbers is realized.

In a preferred embodiment of the present invention, the on-line management of the experimental task, the experimental step, the experimental quality control, and the experimental result information by the experimental task management module is specifically: the administrator can combine the actual business situation, customize the experimental step and form information that each step needs to record; meanwhile, allowing an administrator to preset a responsible person of the experimental step; in the experimental process, the person in charge of the experimental step can be changed by combining the actual business situation; when the responsible person of each experimental step logs in the system, the responsible experimental information can be conveniently and rapidly inquired; the experimental tasks of the user and the experimental states of the tasks are rapidly positioned; supporting the association check of sample information and related experimental quality control information of an experimenter; the system function is combined with the actual off-line business of the molecular diagnosis center, so as to assist the experimenter in recording and managing the experimental process and experimental result information.

In a preferred embodiment of the present invention, the genetic data management module provides a safe and effective storage environment for genetic data, clinical phenotype information and experimental information, specifically: the method comprises the steps of supporting a common user to manage data uploaded to a platform; the method supports users to upload and download gene data conveniently and rapidly by using two modes of page uploading and client uploading.

In a preferred embodiment of the present invention, the phenotype data management module is configured to query HPO phenotype information and genotype information for each other specifically: supporting the retrieval of subject information by genetic information, and retrieving genetic information by phenotypic information; and managing one or more than two of HPO phenotype information, clinical electronic medical record information and follow-up information of the testee according to the dimensions of the testee and the sample.

In a preferred embodiment of the present invention, the phenotype data management module is configured to query each other for HPO phenotype information and genotype information, specifically: a) Laboratory personnel supplement HPO phenotype information; b) ICD classification is automatically carried out according to ICD10/11 diseases; c) The system supports the docking with an in-hospital dedicated disease follow-up system, records the unique identification number of the dedicated disease follow-up system, and supports the direct viewing of dedicated disease follow-up information of a certain subject.

In a preferred embodiment of the present invention, the analysis flow management module further provides a platform administrator with a workflow adding function, and a common user can configure operation parameters and support the existing analysis flow to be transplanted to the cloud and to perform online visual operation.

In a preferred embodiment of the invention, the task management module has rich chart display and data list display according to actual requirements in the analysis result report.

In a preferred embodiment of the invention, the report management module also supports checking report template configuration.

In a preferred embodiment of the present invention, the content of the report display generated by the statistical analysis module during the statistical and analysis of the business data includes: one or a combination of any two or more of resource usage, sample conditions, patient conditions, experimental progress, analytical progress, reporting conditions, laboratory and department personnel attendance.

By adopting the technical scheme, the intelligent comprehensive management system for the precise medical molecular genetic laboratory has the following advantages: a comprehensive professional data platform is established as an infrastructure, clinical data and histology data are effectively integrated, a multi-level biomedical data system is formed, high-level scientific research and clinical application of accurate medicine are supported, and standard standards are established.

Drawings

FIG. 1 is a schematic interface diagram of a subscriber management module according to the present invention.

FIG. 2 is a schematic diagram of an interface of the rights management module of the present invention.

Fig. 3 is an interface schematic diagram of a detection list information display module in the detection management module according to the present invention.

Fig. 4 is an interface schematic diagram of a new detection module in the detection management module according to the present invention.

Fig. 5 is an interface schematic diagram of an experimental task allocation module in the detection management module according to the present invention.

Fig. 6 is an interface schematic diagram of a sample information registration module in the detection management module according to the present invention.

Fig. 7 is an interface schematic diagram of an add-on detection report module in the detection management module according to the present invention.

Fig. 8 is an interface schematic diagram of a detection information search module in the detection management module according to the present invention.

FIG. 9 is a schematic diagram of an interface of a detection accessory management module in the detection management module according to the present invention.

FIG. 10 is a schematic diagram of an interface of a detection project management module in the detection management module according to the present invention.

Fig. 11 is an interface schematic diagram of an experimental sample list information display module in the sample library management module according to the present invention.

FIG. 12 is an interface diagram of a sample preprocessing module in the sample library management module of the present invention.

Fig. 13 is an interface schematic diagram of a sample in-out-in-storage recording module in a sample library management module according to the present invention.

Fig. 14 is an interface schematic diagram of an experimental task list module in the experimental task management module according to the present invention.

Fig. 15 is an interface schematic diagram of an experimental single-step experimental core information recording module in the experimental task management module of the present invention.

FIG. 16 is a schematic diagram of an interface for the operation of the experiment task batch start and end modules in the experiment task management module of the present invention.

Fig. 17 is an interface schematic diagram of an experimenter adjustment module in the experimental task management module of the invention.

Fig. 18 is an interface schematic diagram of an experimental task configuration module in the experimental task management module according to the present invention.

Fig. 19 is an interface schematic diagram of an experiment quality control management module in the experiment task management module of the present invention.

FIG. 20 is a schematic diagram of an interface of a gene data management module according to the present invention.

FIG. 21 is a diagram illustrating an interface of a data upload client in the Gene data management Module of the present invention.

FIG. 22 is a schematic interface diagram of a clinical phenotype data management module of the present invention.

FIG. 23 is a schematic interface diagram of a data query module in the clinical phenotype data management module of the present invention.

FIG. 24 is a schematic interface diagram of an analysis tool management module according to the present invention.

FIG. 25 is a schematic interface diagram of an analysis flow management module according to the present invention.

FIG. 26 is a schematic diagram of an interface of an analysis task management module according to the present invention.

Fig. 27 is an interface schematic diagram of a report list information display module in the report management module according to the present invention.

FIG. 28 is a schematic diagram of an interface of an online detection report writing module in the detection report management module according to the present invention.

FIG. 29 is a schematic diagram illustrating an interface of a report signature setting module in a detection report management module according to the present invention.

FIG. 30 is a diagram showing an interface of a gene information search module in the knowledge base management module according to the present invention.

FIG. 31 is a schematic diagram showing an interface of a gene information display module in the knowledge base management module according to the present invention.

FIG. 32 is a schematic interface diagram of a business statistics large screen in the statistics analysis module of the present invention.

FIG. 33 is a schematic diagram of an interface for business data management statistics in the statistics analysis module of the present invention.

FIG. 34 is a schematic diagram of an interface for traffic statistics in the statistics analysis module of the present invention.

Detailed Description

The invention is further described below with reference to the drawings and detailed description.

The invention relates to an intelligent comprehensive management system of an accurate medical molecular genetic laboratory, which comprises the following components:

the application layer provides management operation and system management operation of specific application services;

the service layer provides a background service operation interface entry and related function management services;

an infrastructure layer providing computing, storage resources and a network environment;

the intelligent comprehensive management system for the precise medical molecular genetic laboratory specifically comprises the following modules:

1. user management module

The user management module manages the user information online. The login information of the common user is initialized online by a system administrator; the system administrator is realized to configure user authority information and reset login passwords on line; the basic information of the account number is maintained by a common user (as shown in fig. 1).

2. Rights management module

The rights management module is mainly used for isolating the rights of users, except for an administrator, each user can only see the folder and the data in the folder, no rights are given to other user data, and only the public data is read and written (as shown in figure 2).

The method is readable: information of the file can be seen in the system;

the method can write: files and their specific information may be created, modified and deleted.

3. Detection management module

The detection management module mainly realizes the on-line management of the gene detection application form of the testee. When a paper detection application form and a physical sample of a subject (a sample meeting the initial examination requirement of a laboratory) are received offline by a sample manager of the laboratory, the beginning of a laboratory business process is symbolized. Laboratory personnel can check and monitor basic information of a subject detection application, the progress condition of an experiment task and the report progress condition of a detection result through detection management.

The detection management module specifically comprises:

3.1. detection list information display module

The detection list information display module realizes that laboratory personnel view detection list information on line and detect the progress condition of the project of each subject. For example: the completion of the experimental task; report writing, auditing, issuing progress status, etc. (see fig. 3).

3.2. Newly added detection module

The newly added detection module realizes the online registration of the detection application form information of the detected person by the sample manager. The system supports batch uploading of detection information through Excel documents. The provided core functions all provide RESTful API, support the docking with the in-hospital system, and simplify the detection application information input operation (as shown in figure 4).

3.3. Experimental task distribution module

The experiment task allocation module realizes that a sample manager and a detection responsible person allocate specific experiment tasks, experiment responsible persons and other information according to detection items in a detection application form (as shown in figure 5).

3.4. Sample information registration module

The sample information registration module realizes sample management and registration of sample information of a subject by a registrar. For example: sample source, sample type, date of receipt, etc. (see fig. 6).

3.5. Adding detection report module

The addition detection report module is used for adding a detection report template of the detected person in combination with the detection project of the detection application form (as shown in fig. 7).

3.6. Detection information searching module

The detection information searching module realizes the retrieval and result display of laboratory personnel according to information such as detection numbers, names of detected subjects, detection items, inspection dates and the like (as shown in fig. 8).

3.7. Detecting attachment management module

The detection accessory management module realizes the online management of the data related to detection as accessories and supports the uploading, downloading and online display (formats: pictures and pdf documents) of the data (as shown in fig. 9).

3.8. Family information management module

The family information management module mainly constructs family information of a subject and a slave subject through the detection management module, correlates basic information and sample information, and supports searching according to family numbers.

3.9. Detection project management module

The detection project management module provides business processes related to detection projects and CRF field template configuration services. According to the actual situation, the inspection items currently involved are configured into the system. The support system administrator configures the experimental project, default experimenters, expected period of the experimental project and the like on line according to different detection projects (see fig. 10).

3.10. Clinical phenotype management module

The clinical phenotype management module is mainly used for recording HPO phenotype information when registering detection application forms and sample information. The laboratory staff adds HPO phenotype information to the subject according to the description information such as clinical characteristics, laboratory indexes and the like in the detection application form. Meanwhile, the experimenter is supported to combine the detection result information to modify/perfect HPO phenotype information.

4. Sample library management module

The sample library management module mainly realizes the on-line management of experimental samples. The system function is combined with the laboratory offline business operation to complete pretreatment of samples (sample separation, DNA extraction, bar code pasting and the like) and management of laboratory samples in and out of warehouse. When the sample manager registers sample information, the system supports automatic generation of sample numbers according to the coding rules of the molecular diagnosis center, and is connected with a printer in a butting mode, so that printing of the sample numbers is realized.

The sample library management module specifically comprises:

4.1. experimental sample list information display module

The experimental sample list information display module realizes that a sample manager and an experimenter view information of laboratory samples on line. For example: sample number, sample type, sample storage location (whole blood, reservoir, working fluid location) (see fig. 11).

4.2. Experimental sample classification retrieval module

The experimental sample classification retrieval module supports the on-line query retrieval of a sample manager and an experimenter according to the information such as sample numbers, sample types, sample storage positions (whole blood, liquid storage, working solution positions) and the like.

4.3. Sample preprocessing module

The sample preprocessing module is used for preprocessing the original sample of the testee by combining with the actual situation of a laboratory. For example: sample separation, sample DNA extraction and the like. When sample pretreatment is completed, laboratory samples (see fig. 12) are generated for specific warehousing.

4.4. Sample information Excel export module

The sample information Excel export module realizes batch export of sample information into an Excel table, and assists a sample manager and an experimenter in searching corresponding samples in the experimental process.

4.5. Sample warehouse-in and warehouse-out recording module

The sample warehouse-in and warehouse-out recording module mainly records sample warehouse-in and warehouse-out recording information by taking a sample as a center. Support retrieval by sample number. When the experimenter performs the sample in-out operation, the experimenter needs to manage the sample and the experimental sample, fill in the sample consumption, and calculate and display the sample allowance (as shown in fig. 13).

4.6. Sample storage overdue reminding module

The sample storage overdue reminding module mainly realizes the on-line management of the valid period of the stored samples. The sample manager sets the storage validity period according to different types of samples and storage requirements. When a sample in the sample library is about to expire or has expired, the system highlights the sample. Meanwhile, searching according to the 'sample validity period' is supported.

5. Experiment task management module

The experiment task management module mainly realizes the on-line management of the molecular diagnosis center on the experiment tasks, the experiment steps, the experiment quality control and the experiment result information. The administrator can customize the experimental steps and the form information to be recorded for each step in combination with the actual business situation. Meanwhile, the manager is allowed to preset the responsible person of the experimental step. In the experimental process, the person responsible for the experimental steps can be changed by combining the actual business situation. When the responsible person of each experimental step logs in the system, the responsible experimental information can be conveniently and rapidly inquired. And the experimental tasks and the experimental states of the tasks are rapidly positioned. And supporting the association of the experimenters to view the sample information and the related experimental quality control information. The system function is combined with the actual off-line business of the molecular diagnosis center, so as to assist the experimenter in recording and managing the experimental process and experimental result information.

The experimental task management module specifically comprises:

5.1. experimental task list module

The experimental task list module displays information and progress conditions of each experimental task according to experimental task distribution conditions of an experimenter. For example: experiment number, experiment task, experimenter, task status, experiment start time, completion time, etc. (see fig. 14).

5.2. Experimental single-step experimental core information recording module

In the single-step experiment core information recording module, an experimenter can record key result records and quality control information in the experiment process step by step according to SOP information of different experiments (the experiment projects related to different detection projects and the recorded content of each experiment step may be different, and communication confirmation with a hospital is needed). When using the system management task, the experimenter can correlate the experiment task with the sample, and record the sample number used in the current experiment step, the information of the operator, the operation time and the like (as shown in fig. 15).

5.3. Experiment task batch starting and ending module

In the experiment task batch starting and ending module, actual business operation of a laboratory realizes batch starting and batch ending of experiment tasks. At the beginning of an experimental task, the lot number for this step is automatically generated and a query by lot number is supported (see fig. 16).

5.4. Experimenter adjusting module

The experimenter adjusting module mainly realizes the information of the experimenters who manage each step according to the experimental steps. The support system administrator assigns a default experiment responsible person according to the experiment steps. The experimenter information (fig. 17) responsible for each specific experimental step is adjusted according to the actual conditions during the experiment.

5.5. Experimental task classification retrieval module

The experimental task classification retrieval module supports online retrieval of information such as experimental numbers, sample numbers, experimental tasks, experimental responsible persons, experimental task states and the like.

5.6. Experimental task configuration module

The experimental task configuration module mainly realizes the default configuration of the experimenters corresponding to the experimental tasks, and a plurality of experimenters are supported to be grouped by default. The system administrator assigns default experiment responsible persons according to the experiment steps, and simultaneously supports reassignment of the experiment responsible persons in the experiment process, and achieves classified display according to the experiment tasks or responsible persons (as shown in fig. 18).

5.7. Experiment quality control management module

The experimental quality control management module realizes experimental quality control according to experimental SOP. When the data results generated during the course of the experiment are in the risk interval, the assignment of a specific experimental auditor audit confirmation is supported (see fig. 19).

6. Data management module

The data management module is mainly divided into two parts: a genetic data management module and a clinical phenotype data management module.

6.1. Gene data management module

The gene data management module is mainly used for providing a safe and effective storage environment for gene data. And the common user is supported to manage the data which is uploaded to the system. The user can upload and download the gene data conveniently and rapidly by using two modes of page uploading and client uploading (shown in figures 20 and 21).

The browser supports uploading and downloading of data files with the data size not exceeding 100 MB;

the client supports uploading and downloading of data files with any size and supports breakpoint continuous transmission;

the client supports the cutting and blocking of the large gene data file and the compression algorithm on the FASTQ file.

6.2. Clinical phenotype data management module

The clinical phenotype data management module is used for collecting and storing clinical phenotype data and is mainly responsible for collecting, standardizing and storing basic information and report information of a subject. Aiming at clinical data such as related examination reports of the testees and pictures, the system provides a picture uploading tool for clinical users to upload related clinical data and image information. Subject HPO phenotype information, clinical electronic medical record information, follow-up information, etc. are managed in the dimensions of the subject and sample (see fig. 22).

a) Laboratory personnel (e.g.: sample administrator, enroller) to supplement HPO phenotype information;

b) According to ICD10/11 disease classification, for example, ICD classification is automatically performed after a certain disease is diagnosed;

c) Support interfacing with an in-hospital dedicated disease follow-up system. The unique identification number of the spot follow-up system is recorded in the molecular diagnosis center system, and the spot follow-up information of a certain subject is directly checked in the molecular diagnosis center system.

6.3. Data query module

The data query module mainly realizes the mutual query of HPO phenotype information and genotype information, supports the retrieval of the information of a subject through the gene information, and retrieves the gene information through the phenotype information (as shown in figure 23).

7. Analysis tool management module

In the analysis tool management module, a platform administrator uses a Docker to make a tool image, and the image is uploaded to the platform through a service provided by the platform. The administrator user can not only view the information of the tool list, the tool description, the tool version and the like on line, but also run the tool in a single step to test whether the tool can normally run and the running result (as shown in fig. 24).

8. Analysis flow management module

In the analysis flow management module, workflow management supports a biological information manager to realize management and operation functions of a gene analysis flow in a graphical mode. The system administrator has the added function of the genetic analysis flow, and the common user can only configure the operation parameters. Support for the migration of existing analysis procedures from hospitals into the system and for on-line visualization runs (see fig. 25).

9. Analysis task management module

The analysis task management module can mainly see all the information such as task names, task creation time, task current state and the like. Report management can mainly see information such as operation parameters, operation logs, result reports and the like. In the analysis result report, there are rich chart display, data list display and the like according to the actual requirements (fig. 26).

10. Detection report management module

The detection report management module mainly realizes the online management (writing, auditing, issuing, downloading, printing and the like) of the detection result report of a report writer, an auditor and an issuer. The system supports inspection report template configuration. The report template can support various content formats such as text, forms, pictures and the like. The system supports the operations of writing, auditing, issuing, downloading (PDF format), printing and the like of the report according to different role rights.

The detection report management module specifically comprises:

10.1 detection report list information display module

The detection report list information display module realizes the online management of the detection result report list information of the detected person by the report writer, the auditor and the issuer. Support for monitoring progress of the detection report from writing to issuing (see fig. 27).

10.2. On-line writing module for detection report

The detection report online writing module realizes that a report writer fills in core content in the detection report online and generates a final previewable and downloadable detection result report by combining with a default detection report template. By combining the information of the 'gene knowledge base', the description information corresponding to the gene locus can be automatically complemented when the report is written (as shown in figure 28).

10.3. Online auditing module for detection report

The on-line examination module of the detection report realizes examination of the detection result report of the examination by a report auditor, and can update the state of the detection result report into writing or waiting to be issued by combining the actual situation. And meanwhile, the report auditor submits audit suggestions in the audit process.

10.4. Detection report issuing module

After the detection report issuing module achieves detection report checking, the detection report issuing module can directly issue the detection report through the system. When the information is issued, the information of an experimenter, an auditor, an issuer and the like is automatically supplemented into the detection result report by combining the content of the actual report template.

10.5 report signature setup Module

The report signature setting module supports configuration of signature information at the user management module, and automatically generated pictures by using a word stock. When the issuer issues a report, the signature of the system configuration is read by default and the report fixed location is presented (see fig. 29).

11. Knowledge base management module

The knowledge base management module mainly realizes the on-line management of gene information, and provides a knowledge framework for the subjects by using diseases, such as: clinical symptoms, treatment routes, disease ICD-10, phenotypic HPO, and the like. Supporting the search for diseases and phenotypes, and displaying the searched results on line, wherein the contents comprise: basic information, mutation information, expression level, related diseases, references, and the like.

11.1. Gene information search module

The gene information search module supports the search conditions such as gene names, mutation sites and the like to search for gene information (see FIG. 30).

11.2. Gene information display module

The gene information display module mainly realizes the online display of the gene detailed information (as shown in fig. 31).

11.13. Gene information import module

The gene information import module mainly realizes that a system administrator downloads a knowledge base data import template Excel in a unified format on line. And the template data importing function is supported, and batch uploading and knowledge base information updating are realized.

12. Statistical analysis module

The statistical analysis module mainly realizes the service data statistical function of the molecular diagnosis center. The system needs to support a Dashboard display function, and the displayed content comprises: resource usage, sample conditions, patient conditions, experimental progress, analytical progress, reporting conditions, laboratory and laboratory personnel attendance, and the like.

The statistical analysis module specifically comprises:

12.1 System statistics Large Screen

The system statistics large screen mainly realizes service statistics of the molecular diagnosis center. Each teacher in the molecular diagnosis center can view the business progress in real time (fig. 32 and 33).

12.2 service statistics Module

The business statistics module combines the actual demands of all teachers in a laboratory, performs data statistics according to dimensions of samples, detection projects, HPO phenotypes, gene loci and the like, and supports the derivation of statistical results from Excel (shown in figure 34).

13. In-hospital system docking

The method comprises the steps of supporting docking with a hospital HIS, LIS, PACS and an electronic medical record system, combining actual business scene capture data of a molecular laboratory, and storing related electronic medical record information; the gene detection report supporting the molecular diagnosis system of Xinhua hospital can be directly transmitted back to the HIS system in the hospital. The subject can download and print the gene detection result report through the in-hospital HIS system.

The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the foregoing embodiments, which have been described in the foregoing embodiments and description merely illustrates the principles of the invention, and that various changes and modifications may be effected therein without departing from the spirit and scope of the invention as defined in the appended claims and their equivalents.

Claims (13)

1. An intelligent integrated management system for an accurate medical molecular genetic laboratory, which is characterized by comprising:

the application layer provides management operation and system management operation of specific application services;

the service layer provides a background service operation interface entry and related function management services;

an infrastructure layer providing computing, storage resources, and a network environment, wherein:

the intelligent comprehensive management system of the precise medical molecular genetic laboratory specifically comprises:

the user management module is used for managing the user information on line;

the permission management module isolates and manages permissions of users for accessing various resources;

the detection management module is used for carrying out online management on the gene detection application form of the detected person;

the sample library management module is used for managing the experimental samples on line;

the experiment task management module is used for managing experiment tasks, experiment steps, experiment quality control and experiment result information on line;

the gene data management module provides a safe and effective storage environment for gene data, clinical phenotype information and experimental information;

a phenotype data management module for querying each other for HPO phenotype information and genotype information;

the analysis tool management module provides a storage environment for using tools in gene analysis and provides basic services for construction of an analysis flow; the online and visual operation and the test of the analysis tool are supported;

an analysis flow management module providing a workflow management page supporting a biological information manager to manage and run a workflow in a graphical manner;

the task management module is used for managing all task names, task creation time, task current states, row parameters, operation logs and result reports;

the report management module is used for online management of detection result reports of report writers, auditors and issuers;

the statistical analysis module is used for statistics and analysis of service data;

the knowledge base module is used for carrying out online management on the gene information and providing a knowledge framework by taking diseases as topics;

and the in-hospital system docking module is used for docking with the in-hospital HIS, LIS, PACS and electronic medical record systems, capturing data by combining with actual business scenes of the molecular laboratory and storing related electronic medical record information.

2. The intelligent integrated management system of an excimer inheritance laboratory of claim 1, wherein the on-line management of user information by the user management module is specifically: the login information of the common user is initialized online by a system administrator; the system administrator is realized to configure user authority information and reset login passwords on line; the basic information of the account number is maintained by the common user.

3. The intelligent comprehensive management system of the precise medical molecular genetic laboratory of claim 1, wherein each type of resource in the rights management module comprises one or a combination of more than two of account number, subject information, detection result, detection report and sample information.

4. The intelligent comprehensive management system of the precise medical molecular genetic laboratory of claim 1, wherein the detection management module is used for on-line management of the gene detection application form of the subject, specifically: when a sample manager of a laboratory receives a paper detection application form and a physical sample of a testee meeting the initial examination requirement of the laboratory offline, the beginning of a laboratory business process is symbolized; laboratory personnel can check and monitor basic information of a subject detection application, the progress condition of an experiment task and the report progress condition of a detection result through detection management.

5. The intelligent comprehensive management system of the precise medical molecular genetic laboratory of claim 1, wherein the sample library management module is used for managing experimental samples on line specifically: the system function is combined with the laboratory offline business operation to complete the pretreatment of samples and the management of laboratory samples in and out of warehouse; when the sample manager registers sample information, the system supports automatic generation of sample numbers according to the coding rules of the molecular diagnosis center, and is connected with a printer in a butting mode, so that printing of the sample numbers is realized.

6. The intelligent comprehensive management system of the precise medical molecular genetic laboratory of claim 1, wherein the on-line management of the experimental task, the experimental step, the experimental quality control and the experimental result information by the experimental task management module is specifically: the administrator can combine the actual business situation, customize the experimental step and form information that each step needs to record; meanwhile, allowing an administrator to preset a responsible person of the experimental step; in the experimental process, the person in charge of the experimental step can be changed by combining the actual business situation; when the responsible person of each experimental step logs in the system, the responsible experimental information can be conveniently and rapidly inquired; the experimental tasks of the user and the experimental states of the tasks are rapidly positioned; supporting the association check of sample information and related experimental quality control information of an experimenter; the system function is combined with the actual off-line business of the molecular diagnosis center, so as to assist the experimenter in recording and managing the experimental process and experimental result information.

7. The intelligent integrated management system of an excimer inheritance laboratory according to claim 1, wherein the gene data management module provides a safe and effective storage environment for gene data, clinical phenotype information and experimental information, specifically: the method comprises the steps of supporting a common user to manage data uploaded to a platform; the method supports users to upload and download gene data conveniently and rapidly by using two modes of page uploading and client uploading.

8. The intelligent integrated management system of an excimer inheritance laboratory according to claim 1, wherein the phenotype data management module is used for inquiring HPO phenotype information and genotype information with each other specifically: supporting the retrieval of subject information by genetic information, and retrieving genetic information by phenotypic information; and managing one or more than two of HPO phenotype information, clinical electronic medical record information and follow-up information of the testee according to the dimensions of the testee and the sample.

9. The intelligent integrated management system for an excimer laser laboratory according to claim 8, wherein the phenotype data management module is further configured to query the HPO phenotype information and the genotype information for each other: a) Laboratory personnel supplement HPO phenotype information; b) ICD classification is automatically carried out according to ICD10/11 diseases; c) The system supports the docking with an in-hospital dedicated disease follow-up system, records the unique identification number of the dedicated disease follow-up system, and supports the direct viewing of dedicated disease follow-up information of a certain subject.

10. The intelligent comprehensive management system of the precise medical molecular genetic laboratory of claim 1, wherein the analysis flow management module further provides a workflow adding function for a platform administrator, and a common user can configure operation parameters and support the existing analysis flow to be transplanted to the cloud and to be visually operated on line.

11. The intelligent integrated management system of the precise medical molecular genetic laboratory of claim 1, wherein the task management module has rich chart display and data list display according to actual requirements in the analysis result report.

12. The integrated intelligent management system for an excimer laser genetics laboratory of claim 1 wherein said report management module further supports inspection report template configuration.

13. The intelligent integrated management system for an excimer laser genetics laboratory of claim 1 wherein said statistics analysis module is adapted to display reports of business data statistics and analysis comprising: one or a combination of any two or more of resource usage, sample conditions, patient conditions, experimental progress, analytical progress, reporting conditions, laboratory and department personnel attendance.