CN116919704B - Environment-friendly artificial fistula bag convenient to firmly connect and preparation method thereof - Google Patents

Environment-friendly artificial fistula bag convenient to firmly connect and preparation method thereof Download PDF

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Publication number
CN116919704B
CN116919704B CN202311198711.XA CN202311198711A CN116919704B CN 116919704 B CN116919704 B CN 116919704B CN 202311198711 A CN202311198711 A CN 202311198711A CN 116919704 B CN116919704 B CN 116919704B
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antioxidant
bag body
pla
chain extender
bag
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CN202311198711.XA
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CN116919704A (en
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阎泽朋
杨瑜
刘明哲
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Shandong Xuxi New Material Technology Co ltd
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Shandong Xuxi New Material Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F5/00—Orthopaedic methods or devices for non-surgical treatment of bones or joints; Nursing devices; Anti-rape devices
    • A61F5/44—Devices worn by the patient for reception of urine, faeces, catamenial or other discharge; Portable urination aids; Colostomy devices
    • A61F5/445—Colostomy, ileostomy or urethrostomy devices
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/08—Copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2403/00—Characterised by the use of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08J2403/02—Starch; Degradation products thereof, e.g. dextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2423/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2423/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2423/04—Homopolymers or copolymers of ethene
    • C08J2423/08—Copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2467/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2467/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/24—Acids; Salts thereof
    • C08K3/26—Carbonates; Bicarbonates
    • C08K2003/265—Calcium, strontium or barium carbonate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
    • Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
    • Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics

Abstract

The invention discloses an environment-friendly artificial fistula bag convenient for stable connection and a preparation method thereof, belonging to the technical field of artificial fistula bags, comprising a bag body, wherein the bag body comprises a front degradation membrane and a rear degradation membrane, and is characterized in that: the interface card is fixed on the rear degradation membrane and is made of PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant according to the mass ratio of 65-75:18-22:20-30:0.15-0.25:0.15-0.25 in sequence, and the interface card further comprises a rubber adhesion ring arranged on the binding belt, and the interface card is detachably and hermetically connected with the rubber adhesion ring. The artificial fistula bag not only meets the biological degradation performance of the bag body, but also enhances the hardness of the bag body at the site of the fistulization, thereby being beneficial to enhancing the stability of the connection between the bag body and the site of the fistulization; meanwhile, the interface can be connected with the internal degradation membrane through a heat sealing process, so that the process is simplified, and the connection strength is enhanced.

Description

Environment-friendly artificial fistula bag convenient to firmly connect and preparation method thereof
Technical Field
The invention belongs to the technical field of artificial fistula bags, and particularly relates to an environment-friendly artificial fistula bag convenient to firmly connect and a preparation method thereof.
Background
With the development of medical science and technology, a plurality of diseases can be effectively treated, and good news is brought to the life health of people. Among them, the ostomy makes a contribution which causes the number of fistulae to increase gradually, and the need for a household ostomy bag to serve the fistulae is increasing.
At present, most of household artificial fistula bags in the market are made of high polymer plastic film materials, patients are generally classified into common household garbage after using the household fistula bags, the common household garbage is generally incinerated, and the plastic fistula bags easily produce toxic and harmful substances such as dioxin in incineration, so that environmental pollution is caused, and the household fistula bags do not meet the social requirements of green development.
In recent years, with the development of emerging degradation materials, a variety of degradation films with different functions are emerging. Thus, it is contemplated that the use of a degradable film in an artificial fistula bag, but since the existing degradable films are all soft silk-thin articles, a sealed connection with the artificial fistula cannot be achieved.
Disclosure of Invention
The invention aims to solve the technical problem of providing an environment-friendly artificial fistula bag convenient for stable connection and a preparation method thereof, which are convenient for realizing reliable connection on the premise of biodegradation.
In order to solve the technical problems, the technical scheme of the invention is as follows: the utility model provides an environmental protection artificial fistula bag convenient to firm connection, includes the bag body, and the bag body includes preceding degradation diaphragm and back degradation diaphragm, its characterized in that: the interface card is fixed on the rear degradation membrane and is prepared from PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant, wherein the mass ratio of the PBS, the PLA, the active calcium powder, the compatilizer, the first chain extender to the first antioxidant is 65-75:18-22:20-30:0.15-0.25:0.15-0.25 in sequence;
still include the band, be fixed with rubber adhesion circle on the band, interface card and rubber adhesion circle detachable sealing connection.
Preferably, the front degradation membrane and the rear degradation membrane are composed of an outer protection layer, a middle barrier layer and an inner heat sealing layer;
the outer protective layer is prepared from PBAT, PLA, starch, a second chain extender and a second antioxidant, wherein the mass ratio of the PBAT, the PLA, the starch, the second chain extender and the second antioxidant is 70-90:6-8:20-30:1-3:0.15-0.25 in sequence;
the middle barrier layer is prepared from EVOH, polyhydroxyalkanoate and a third antioxidant, wherein the mass ratio of the EVOH to the polyhydroxyalkanoate to the third antioxidant is 45-55:45-55:0.2 in sequence;
the internal heat sealing layer is composed of PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant, wherein the mass ratio of the PBAT, the PLA, the third chain extender, the fourth antioxidant and the lubricant is 80-90:10-12:1-3:0.15-0.25:0.15-0.25 in sequence.
Preferably, the outer wall of the rear degradation membrane is coated with polylactic acid non-woven fabrics.
Preferably, the lower end of the bag body is provided with an opening communicated with the inner cavity of the bag body, the opening is provided with a sealing clamp, the sealing clamp is made of PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant, and the mass ratio of the PBS, the PLA, the active calcium powder, the compatilizer, the first chain extender to the first antioxidant is 65-75:18-22:20-30:0.15-0.25:0.15-0.25 in sequence.
Preferably, the interface card is in clamping connection with the rubber adhesive ring.
Preferably, the thickness of the front degradation membrane and the rear degradation membrane is 120-150 mu m, and the thickness ratio of the outer protective layer to the middle barrier layer to the inner heat sealing layer is 40:20:80.
The invention also provides a method for preparing the environment-friendly artificial fistula bag convenient for stable connection, which comprises the following steps:
(1) Preparing a special protective material: the PBAT, PLA, starch, a second chain extender and a second antioxidant are mixed sequentially according to the mass ratio of 70-90:6-8:20-30:1-3:0.15-0.25 to obtain a first mixture, and the first mixture is granulated to obtain a special material for protection;
(2) Preparing a special barrier material: mixing EVOH, polyhydroxyalkanoate and a third antioxidant sequentially according to the mass ratio of 45-55:45-55:0.2 to obtain a second mixture, and granulating the second mixture to obtain a special barrier material;
(3) Preparing a special material for heat sealing: the PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant are mixed sequentially according to the mass ratio of 80-90:10-12:1-3:0.15-0.25:0.15-0.25 to obtain a third mixture, and the third mixture is granulated to obtain a special heat sealing material;
(4) And (3) co-extrusion film forming: the special protective material prepared in the step (1), the special barrier material prepared in the step (2) and the special heat seal material prepared in the step (3) are subjected to multi-layer coextrusion blowing to form an outer protective layer, an intermediate barrier layer and an inner heat seal layer which are sequentially distributed from outside to inside of the degradation film, wherein the extrusion temperature of the special protective material and the special heat seal material is 200-220 ℃, and the extrusion temperature of the special barrier material is 160-180 ℃.
(5) And (3) bag making: heat-sealing the two heat-sealing layers of the degradation film prepared in the step (4) together to prepare a bag body; the obtained bag body is provided with a front degradation membrane and a rear degradation membrane;
(6) Preparing an interface card: PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed sequentially according to the mass ratio of 65-75:18-22:20-30:0.15-0.25:0.15-0.25 to obtain a fourth mixture, the fourth mixture is granulated to obtain a master batch, and the master batch is injection molded to obtain the interface card;
(7) Configuration: the interface card prepared in the step (6) is thermally sealed on the degradation membrane prepared in the step (4), and the interface card is positioned on the post degradation membrane of the bag body prepared in the step (5); or the interface card prepared in the step (6) is thermally sealed on the post-degradation membrane of the bag body prepared in the step (5);
the interface card can be in sealing connection with the rubber adhesive ring.
Preferably, in the step (5), an opening is reserved at the lower end of the bag body;
the method also comprises the steps of preparing the sealing clamp: PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed sequentially according to the mass ratio of 65-75:18-22:20-30:0.15-0.25:0.15-0.25 to obtain a fourth mixture, the fourth mixture is granulated to obtain a master batch, the master batch is injection molded to obtain a sealing clamp, and the sealing clamp is arranged on an opening of a bag body.
Preferably, in the step of preparing the interface card and the sealing clamp, the granulating temperature is 180-220 ℃ and the injection molding temperature is 200-230 ℃.
Preferably, the back degradable film sheet of the bag body is coated with polylactic acid non-woven fabric.
Preferably, the first chain extender, the second chain extender and the third chain extender are ADRs.
Preferably, the first antioxidant, the second antioxidant, the third antioxidant and the fourth antioxidant are antioxidants 168.
Preferably, the compatibilizer is a stearic acid.
Preferably, the lubricant is a stearate.
Preferably, the granulation temperature in step (1) and step (3) is 180 to 220 ℃.
Preferably, the granulation temperature in step (2) is 190 to 230 ℃.
Compared with the prior art, the invention has the beneficial effects that:
1. the interface card with a specific formula not only meets the biodegradability of the bag body, but also enhances the hardness of the bag body at the site of fistulization, thereby being beneficial to enhancing the stability of the connection between the bag body and the site of fistulization; meanwhile, the interface can be connected with the internal degradation membrane through a heat sealing process, so that the process is simplified, and the connection strength is enhanced.
2. The invention can apply the rubber adhesive ring on the skin of the fistulization part of a patient and fasten the rubber adhesive ring by the binding belt, thereby laying a precondition for the interface card to realize the stable connection with the fistulization part by the sealing connection with the rubber adhesive ring; and through detachable connection, the bag body can be replaced frequently on the premise of reducing the use cost by repeatedly using the binding belt for a plurality of times.
3. According to the invention, through the specific formulation of the front degradation membrane and the rear degradation membrane, the biological degradation can be performed more quickly, the barrier property is good, the exudation of the contained matters and the emission of peculiar smell are prevented, and the use experience is good; and the bag forming process can be simplified by thermally synthesizing the bag, and the bag has an outer protective layer with higher relative strength, thereby being beneficial to reducing the damage degree of the bag body.
4. Because the polylactic acid non-woven fabrics are coated on the outer wall of the rear degradation membrane, the abnormal sense caused by direct contact between the film bag body and the skin of a human body can be reduced, and the comfort level of a patient during wearing can be enhanced.
5. Because the lower end of the bag body is provided with an opening communicated with the inner cavity of the bag body, and the opening is provided with a sealing clamp, a patient can unload the contained objects in the bag at any time according to the needs, and the service time of the bag body is prolonged; the sealing clamp has the same hardness and degradability as the interface card, can be biodegraded finally while meeting the requirement of stable sealing, and is safe and environment-friendly.
6. The invention has unique conception, realizes each functional layer through the compatibility of raw materials, also gives consideration to the combination property of each functional layer, makes the functional layer become a tightly combined integrated structure, and is convenient for popularization and application in industry by being provided with a specific interface card for fistulization patients.
Drawings
FIG. 1 is a perspective view of the present invention;
FIG. 2 is a view in the direction A of FIG. 1;
fig. 3 is an enlarged view of a portion I in fig. 1.
The marks in the figure: 1. post-degrading the membrane; 2. front degradation membrane; 3. a binding belt; 4. sealing clips; 5. an interface card; 6. a rubber adhesive ring; 7. polylactic acid non-woven fabrics.
Detailed Description
The invention is described in further detail below in connection with specific embodiments.
When the bag is in a use state, one side of the bag body, which is worn close to a human body, is defined as a rear side, and the other side of the bag body, which is far away from the human body, is defined as a front side; one side close to the interior cavity of the bag is defined as the inner side, and the other side away from the interior cavity of the bag is defined as the outer side.
Example 1
An artificial fistula bag is made by the steps of:
(1) Preparing a special protective material: sequentially mixing PBAT, PLA, starch, a second chain extender and a second antioxidant according to the mass ratio of 70:8:20:3:0.25 to obtain a first mixture, and granulating the first mixture at the temperature of 180 ℃ to obtain a special material for protection;
(2) Preparing a special barrier material: mixing EVOH, polyhydroxyalkanoate and a third antioxidant sequentially according to the mass ratio of 45:55:0.2 to obtain a second mixture, and granulating the second mixture at the temperature of 190 ℃ to obtain a special barrier material;
(3) Preparing a special material for heat sealing: mixing PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant in sequence according to the mass ratio of 80:12:3:0.15:0.25 to obtain a third mixture, and granulating the third mixture at the temperature of 180 ℃ to obtain a special heat seal material;
(4) And (3) co-extrusion film forming: the special protective material prepared in the step (1), the special barrier material prepared in the step (2) and the special heat seal material prepared in the step (3) are subjected to multi-layer coextrusion blowing to form an outer protective layer, an intermediate barrier layer and an inner heat seal layer which are sequentially distributed from outside to inside of the degradation film, wherein the extrusion temperature of the special protective material and the special heat seal material is 200 ℃, and the extrusion temperature of the special barrier material is 160 ℃; the degradable film with the thickness of 120 mu m is prepared, wherein the thickness ratio of the outer protective layer to the middle barrier layer to the inner heat sealing layer is 40:20:80;
(5) And (3) bag making: the two internal heat sealing layers of the degradation films prepared in the step (4) are thermally bonded together to prepare a bag body, the obtained bag body is provided with a front degradation film sheet 2 and a rear degradation film sheet 1, and an opening is reserved at the lower end of the bag body;
(6) Preparing interface card 5 and sealing clamp 4: sequentially mixing PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant according to the mass ratio of 65:22:20:0.25:0.15:0.25 to obtain a fourth mixture, granulating the fourth mixture to obtain a master batch, wherein the granulating temperature of the master batch is 180 ℃, respectively preparing an interface card 5 and a sealing clamp 4 by injection molding of the master batch, and clamping the sealing clamp 4 on an opening of a bag body at the injection molding temperature of 200 ℃;
(7) Configuration: the interface card 5 prepared in the step (6) is thermally sealed on the degradation membrane prepared in the step (4), and the interface card 5 is positioned on the post degradation membrane 1 of the bag body prepared in the step (5); or the interface card 5 prepared in the step (6) is thermally sealed on the post-degradation membrane 1 of the bag body prepared in the step (5), and the interface card 5 can be in sealing connection with the rubber adhesive ring 6.
In order to enhance the comfort of wearing the bag body, the back degradable film 1 of the bag body is further coated with the polylactic acid non-woven fabric 7, and the polylactic acid non-woven fabric 7 and the coating technology thereof on the film are already mature prior art, and are not described in detail herein, and reference is made to the patent application with publication number CN 110641102A. The first chain extender, the second chain extender and the third chain extender are ADR, and other chain extenders can be adopted as long as the chain extender can play a role in chain extension, and the specific requirements on the materials of the chain extender are not met. The first antioxidant, the second antioxidant, the third antioxidant and the fourth antioxidant are antioxidant 168, and other antioxidants can be adopted in the same way. The compatilizer adopts stearic acid or other substances of stearic acid. The lubricant may be calcium stearate, or other specific stearate, as long as it is a stearate. The ADR and the antioxidant 168 used are already mature existing products, such as the chain extender ADR and the antioxidant 168 of Basoff, germany, and also the antioxidant 168 of Shanghai chemical Co., ltd, the chain extender ADR of Dongying sea Ruibao New Material Co., ltd.
The invention is also provided with a binding belt 3, the binding belt 3 is fixedly provided with a rubber adhesive ring 6, the interface card 5 and the rubber adhesive ring 6 are connected in a clamping way, in particular, a groove is formed in the rubber adhesive ring 6, a convex ring is arranged on the interface card 5, and the convex ring is clamped in the groove in a sealing way, so that the detachable sealing connection between the interface card 5 and the rubber adhesive ring 6 is realized.
When the artificial fistula bag is used, the rubber adhesive ring 6 is adhered to the skin of a fistulization part of a patient, the rubber adhesive ring 6 is further restrained and fixed by the strap 3, then the bag body is arranged on the rubber adhesive ring 6 through the interface card 5, so that the wearing of the artificial fistula bag by the patient is realized, the excreta of the human body is discharged into the artificial fistula bag through the interface card 5, the patient can open the sealing clamp 4 according to the situation, and the excreta in the artificial fistula bag is discharged through the opening at the bottom; the artificial fistula can be directly removed from the rubber adhesive ring 6, a new artificial fistula bag is replaced, and the removed artificial fistula bag can be put into daily life garbage for composting treatment and natural biodegradation, so that the environment-friendly requirement is met.
Example two
The present embodiment is different from the first embodiment in that:
in the step (1), PBAT, PLA, starch, a second chain extender and a second antioxidant are mixed sequentially according to the mass ratio of 90:6:30:1:0.15 to obtain a first mixture, and the first mixture is granulated at the temperature of 220 ℃ to obtain a special protection material;
in the step (2), EVOH, polyhydroxyalkanoate and a third antioxidant are mixed sequentially according to the mass ratio of 55:45:0.2 to obtain a second mixture, and the second mixture is pelletized at the temperature of 230 ℃ to obtain a special barrier material;
in the step (3), PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant are mixed in sequence according to the mass ratio of 90:10:1:0.25:0.15 to obtain a third mixture, and the third mixture is granulated at the temperature of 220 ℃ to obtain a special heat sealing material;
in the step (4), the extrusion temperature of the special protection material and the special heat seal material is 220 ℃, and the extrusion temperature of the special barrier material is 180 ℃; thus, a degraded film having a thickness of 150 μm was produced;
in the step (6), PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed in sequence according to the mass ratio of 75:18:30:0.15:0.25:0.15 to obtain a fourth mixture, wherein the granulating temperature of the master batch is 220 ℃, and the injection molding temperature is 230 ℃;
the remainder was the same as in the first embodiment.
Example III
The present embodiment is different from the first embodiment in that:
in the step (1), PBAT, PLA, starch, a second chain extender and a second antioxidant are mixed sequentially according to the mass ratio of 80:7:25:2:0.2 to obtain a first mixture, and the first mixture is granulated at the temperature of 200 ℃ to obtain a special protection material;
in the step (2), EVOH, polyhydroxyalkanoate and a third antioxidant are mixed sequentially according to the mass ratio of 50:50:0.2 to obtain a second mixture, and the second mixture is pelletized at the temperature of 210 ℃ to obtain a special barrier material;
in the step (3), PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant are mixed in sequence according to the mass ratio of 85:11:2:0.2:0.2 to obtain a third mixture, and the third mixture is granulated at the temperature of 200 ℃ to obtain a special heat sealing material;
in the step (4), the extrusion temperature of the special protection material and the special heat seal material is 210 ℃, and the extrusion temperature of the special barrier material is 170 ℃; thus, a degraded film having a thickness of 135 μm was produced;
in the step (6), PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed in sequence according to the mass ratio of 70:20:25:0.2:0.2:0.2 to obtain a fourth mixture, wherein the granulating temperature of the master batch is 200 ℃, and the injection molding temperature is 215 ℃;
the remainder was the same as in the first embodiment.
Example IV
The present embodiment is different from the first embodiment in that:
in the step (1), PBAT, PLA, starch, a second chain extender and a second antioxidant are mixed sequentially according to the mass ratio of 70:6:20:1:0.15 to obtain a first mixture, and the first mixture is granulated at the temperature of 190 ℃ to obtain a special protection material;
in the step (2), EVOH, polyhydroxyalkanoate and a third antioxidant are mixed sequentially according to the mass ratio of 45:45:0.2 to obtain a second mixture, and the second mixture is pelletized at the temperature of 200 ℃ to obtain a special barrier material;
in the step (3), PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant are mixed in sequence according to the mass ratio of 80:10:1:0.15:0.15 to obtain a third mixture, and the third mixture is granulated at the temperature of 190 ℃ to obtain a special heat sealing material;
in the step (4), the extrusion temperature of the special protection material and the special heat seal material is 205 ℃, and the extrusion temperature of the special barrier material is 165 ℃; thus, a degradable film having a thickness of 130 μm was produced;
in the step (6), PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed in sequence according to the mass ratio of 65:18:20:0.15:0.15:0.15 to obtain a fourth mixture, wherein the granulating temperature of the master batch is 190 ℃, and the injection molding temperature is 210 ℃;
the remainder was the same as in the first embodiment.
Example five
The present embodiment is different from the first embodiment in that:
in the step (1), PBAT, PLA, starch, a second chain extender and a second antioxidant are mixed sequentially according to the mass ratio of 90:8:30:3:0.25 to obtain a first mixture, and the first mixture is granulated at the temperature of 210 ℃ to obtain a special protection material;
in the step (2), EVOH, polyhydroxyalkanoate and a third antioxidant are mixed sequentially according to the mass ratio of 55:55:0.2 to obtain a second mixture, and the second mixture is pelletized at 220 ℃ to obtain a special barrier material;
in the step (3), PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant are mixed in sequence according to the mass ratio of 90:12:3:0.25:0.25 to obtain a third mixture, and the third mixture is granulated at the temperature of 210 ℃ to obtain a special heat sealing material;
in the step (4), the extrusion temperature of the special protection material and the special heat seal material is 215 ℃, and the extrusion temperature of the special barrier material is 175 ℃; thus, a degraded film having a thickness of 140 μm was produced;
in the step (6), PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are sequentially mixed according to the mass ratio of 75:22:30:0.25:0.25:0.25 to obtain a fourth mixture, wherein the granulating temperature of the master batch is 210 ℃, and the injection molding temperature is 220 ℃;
the remainder was the same as in the first embodiment.
The manufactured artificial fistula bags of the embodiment are subjected to performance tests in terms of thickness, oxygen resistance, water vapor resistance, tensile strength, tearing strength, heat seal stripping, plane dart impact, shore hardness of interface cards and the like, and are subjected to comparison tests with the traditional polyethylene film artificial fistula bags (the interface cards are made of polyethylene). The oxygen blocking test is carried out according to the Coulomb meter detection method of the oxygen permeability test of the plastic film and the sheet of the packaging material of the national standard GB/T19789-2005, the water blocking steam test is carried out according to the cup type weight increasing and weight decreasing method of the water vapor permeability test of the plastic film and the sheet of the national standard GB/T1037-2020, the tensile strength test is carried out according to the test method of the tensile property of the plastic sheet of the ASTM standard D882-02, the tearing strength test is carried out according to the test method of the tensile property of the plastic sheet of the ASTM standard D1004-13, the plane dart drop impact test is carried out according to the free dart method of the impact resistance test method of the plastic film and the sheet of the national standard GB/T9639.1-2008, the heat sealing peeling strength test is carried out according to the test method of the peeling strength of the adhesive tape of the national standard GB/T2792-2014, and the Shore hardness test is carried out according to the pocket hardness test method of the rubber hardness tester of the national standard GB/T531-1999. The test results were as follows:
therefore, the artificial fistula bags prepared by the embodiments of the invention can be comparable with polyethylene films with mature technology in terms of tensile strength, tearing strength and plane dart impact, are obviously superior to the polyethylene films in terms of oxygen resistance, water vapor resistance, heat seal stripping and interface card Shore hardness, can completely replace the polyethylene film artificial fistula bags in the prior art, have no peculiar smell, have good seepage prevention performance and improve the experience of users.
The raw material composition expressed in a closed manner in the invention refers to main raw materials, namely raw materials with the percentage of more than 98.5 percent in the total mass of the raw materials and other trace auxiliary materials can be contained. That is, on the basis of the closed expression raw material composition of the present invention, if the ratio of the added auxiliary material in the total mass of the raw material is not more than 1.5%, the present invention still falls within the protection scope of the present invention.
In the above text, PBAT is a polybutylene terephthalate/adipate copolymer, PLA is polylactic acid, PBS is polybutylene succinate, and EVOH is an ethylene/vinyl alcohol copolymer.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the invention in any way, and any person skilled in the art may make modifications or alterations to the disclosed technical content to the equivalent embodiments. However, any simple modification, equivalent variation and variation of the above embodiments according to the technical substance of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims (9)

1. An environmental protection artificial fistula bag convenient to firm connection, includes the bag body, and the bag body includes preceding degradation diaphragm and back degradation diaphragm, its characterized in that: the interface card is fixed on the rear degradation membrane and is prepared from PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant, wherein the mass ratio of the PBS, the PLA, the active calcium powder, the compatilizer, the first chain extender to the first antioxidant is 65-75:18-22:20-30:0.15-0.25:0.15-0.25 in sequence;
the connector card is detachably connected with the rubber adhesive ring in a sealing way;
the front degradation membrane and the rear degradation membrane are composed of an outer protective layer, a middle barrier layer and an inner heat sealing layer;
the outer protective layer is prepared from PBAT, PLA, starch, a second chain extender and a second antioxidant, wherein the mass ratio of the PBAT, the PLA, the starch, the second chain extender and the second antioxidant is 70-90:6-8:20-30:1-3:0.15-0.25 in sequence;
the middle barrier layer is prepared from EVOH, polyhydroxyalkanoate and a third antioxidant, wherein the mass ratio of the EVOH to the polyhydroxyalkanoate to the third antioxidant is 45-55:45-55:0.2 in sequence;
the internal heat sealing layer is composed of PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant, wherein the mass ratio of the PBAT, the PLA, the third chain extender, the fourth antioxidant and the lubricant is 80-90:10-12:1-3:0.15-0.25:0.15-0.25 in sequence.
2. The environmentally friendly, securely attached, artificial fistula bag of claim 1 wherein: and the outer wall of the rear degradation membrane is coated with polylactic acid non-woven fabric.
3. An environmentally friendly fistula bag for facilitating secure attachment as set forth in claim 1 or 2 wherein: the lower end of the bag body is provided with an opening communicated with the inner cavity of the bag body, the opening is provided with a sealing clamp, the sealing clamp is made of PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant, and the mass ratio of the PBS, the PLA, the active calcium powder, the compatilizer, the first chain extender to the first antioxidant is 65-75:18-22:20-30:0.15-0.25:0.15-0.25 in sequence.
4. An environmentally friendly fistula bag for facilitating secure attachment as set forth in claim 1 or 2 wherein: the interface card is connected with the rubber adhesive ring in a clamping way.
5. An environmentally friendly fistula bag for facilitating secure attachment as set forth in claim 1 or 2 wherein: the thickness of the front degradation membrane and the rear degradation membrane is 120-150 mu m, and the thickness ratio of the outer protective layer to the middle barrier layer to the inner heat sealing layer is 40:20:80.
6. A method of making an environmentally friendly fistula bag of any one of claims 1 to 5 that facilitates secure attachment, comprising: the method comprises the following steps:
(1) Preparing a special protective material: the PBAT, PLA, starch, a second chain extender and a second antioxidant are mixed sequentially according to the mass ratio of 70-90:6-8:20-30:1-3:0.15-0.25 to obtain a first mixture, and the first mixture is granulated to obtain a special material for protection;
(2) Preparing a special barrier material: mixing EVOH, polyhydroxyalkanoate and a third antioxidant sequentially according to the mass ratio of 45-55:45-55:0.2 to obtain a second mixture, and granulating the second mixture to obtain a special barrier material;
(3) Preparing a special material for heat sealing: the PBAT, PLA, a third chain extender, a fourth antioxidant and a lubricant are mixed sequentially according to the mass ratio of 80-90:10-12:1-3:0.15-0.25:0.15-0.25 to obtain a third mixture, and the third mixture is granulated to obtain a special heat sealing material;
(4) And (3) co-extrusion film forming: the special protective material prepared in the step (1), the special barrier material prepared in the step (2) and the special heat seal material prepared in the step (3) are subjected to multi-layer coextrusion blowing to form an outer protective layer, an intermediate barrier layer and an inner heat seal layer which are sequentially distributed from outside to inside of the degradation film, wherein the extrusion temperature of the special protective material and the special heat seal material is 200-220 ℃, and the extrusion temperature of the special barrier material is 160-180 ℃;
(5) And (3) bag making: heat-sealing the two heat-sealing layers of the degradation film prepared in the step (4) together to prepare a bag body; the obtained bag body is provided with a front degradation membrane and a rear degradation membrane;
(6) Preparing an interface card: PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed sequentially according to the mass ratio of 65-75:18-22:20-30:0.15-0.25:0.15-0.25 to obtain a fourth mixture, the fourth mixture is granulated to obtain a master batch, and the master batch is injection molded to obtain the interface card;
(7) Configuration: the interface card prepared in the step (6) is thermally sealed on the degradation membrane prepared in the step (4), and the interface card is positioned on the post degradation membrane of the bag body prepared in the step (5); or the interface card prepared in the step (6) is thermally sealed on the post-degradation membrane of the bag body prepared in the step (5);
the interface card can be in sealing connection with the rubber adhesive ring.
7. The method for making an environmentally friendly fistula bag convenient for firm attachment of claim 6 wherein: in the step (5), an opening is reserved at the lower end of the bag body;
the method also comprises the steps of preparing the sealing clamp: PBS, PLA, active calcium powder, a compatilizer, a first chain extender and a first antioxidant are mixed sequentially according to the mass ratio of 65-75:18-22:20-30:0.15-0.25:0.15-0.25 to obtain a fourth mixture, the fourth mixture is granulated to obtain a master batch, the master batch is injection molded to obtain a sealing clamp, and the sealing clamp is arranged on an opening of a bag body.
8. The method for making an environmentally friendly fistula bag convenient for firm attachment of claim 7 wherein: in the step of preparing the interface card and the sealing clamp, the granulating temperature is 180-220 ℃ and the injection molding temperature is 200-230 ℃.
9. The method of making an environmentally friendly fistula bag facilitating secure attachment as set forth in any one of claims 6 to 8 wherein: the back degradation membrane of the bag body is coated with polylactic acid non-woven fabrics.
CN202311198711.XA 2023-09-18 2023-09-18 Environment-friendly artificial fistula bag convenient to firmly connect and preparation method thereof Active CN116919704B (en)

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US5009648A (en) * 1989-03-22 1991-04-23 E. R. Squibb & Sons, Inc. Starch containing film ostomy pouches
CN1197399A (en) * 1996-05-03 1998-10-28 巴克斯特国际有限公司 Oriented medical tubing
CN105176018A (en) * 2015-10-19 2015-12-23 福建师范大学 PBS (Poly Butylene Succinate)/PHB (Polyhydroxybutyrate) material for 3D (Three-dimensional) printing and preparation method thereof
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