CN116889417A - Children heart CTA scanning system and contrast agent injection method thereof - Google Patents
Children heart CTA scanning system and contrast agent injection method thereof Download PDFInfo
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- 238000002347 injection Methods 0.000 title claims abstract description 102
- 239000007924 injection Substances 0.000 title claims abstract description 102
- 239000002872 contrast media Substances 0.000 title claims abstract description 72
- 238000000034 method Methods 0.000 title claims abstract description 44
- 230000001105 regulatory effect Effects 0.000 claims abstract description 44
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 32
- 239000011780 sodium chloride Substances 0.000 claims abstract description 32
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 230000000747 cardiac effect Effects 0.000 claims description 13
- 230000001276 controlling effect Effects 0.000 claims description 8
- 239000011259 mixed solution Substances 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 230000037396 body weight Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 2
- 238000002591 computed tomography Methods 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 208000002330 Congenital Heart Defects Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000012267 brine Substances 0.000 description 1
- 208000014387 congenital coronary artery anomaly Diseases 0.000 description 1
- 208000028831 congenital heart disease Diseases 0.000 description 1
- 201000011639 coronary artery anomaly Diseases 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000002169 extracardiac Effects 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003062 neural network model Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
- A61B6/035—Mechanical aspects of CT
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- A—HUMAN NECESSITIES
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- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
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- A61B6/48—Diagnostic techniques
- A61B6/481—Diagnostic techniques involving the use of contrast agents
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- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/503—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of the heart
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/178—Syringes
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- A61M5/2066—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically comprising means for injection of two or more media, e.g. by mixing
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
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- A—HUMAN NECESSITIES
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- A61M5/178—Syringes
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
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- A61M5/178—Syringes
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- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
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Abstract
The invention discloses a children heart CTA scanning system and a contrast agent injection method thereof, the scanning system comprises: CTA device and contrast agent injection device; the contrast medium injection device comprises a main control unit and an input unit; a display unit; the main control unit is respectively connected with a first high-pressure injection pump and a second high-pressure injection pump, the first high-pressure injection pump is provided with a contrast medium needle cylinder filled with contrast medium, and the second high-pressure injection pump is provided with a saline needle cylinder filled with saline; the liquid outlet ends of the contrast agent needle cylinder and the saline needle cylinder are respectively connected with the injection tube through a first regulating valve and a second regulating valve; the liquid outlet ends of the contrast agent needle cylinder and the saline needle cylinder are respectively connected with the liquid inlet end of the mixer through a third regulating valve and a fourth regulating valve; when the CTA scanning system adopts the contrast agent injection method to inject the contrast agent, the dosage of the contrast agent is reduced, good image quality is obtained, meanwhile, the consistency of images is ensured, and the treatment of the illness state of the sick children is easy.
Description
Technical Field
The invention relates to the technical field of CTA scanning, in particular to a children heart CTA scanning system and a contrast agent injection method thereof.
Background
Cardiac imaging plays an important role in both congenital and acquired heart disease. Cardiac computed tomography (angiography) CT (a) is now commonly used to assess complex coronary heart disease, providing information on endocardial and extracardiac anatomy, coronary arteries and vascular structures. Heart CTA has become the first examination method for congenital heart disease and coronary artery abnormality in children because of its ability to clearly show the structures of large blood vessels and coronary arteries of the heart. At present, the contrast agent is generally injected according to the experience when the heart CTA of the child is imaged by adopting a traditional two-stage injection scheme, but different children have different body types and different circulation times, and the injection with an experience value can cause poor imaging effect, influence the consistency of images, reduce the diagnosis accuracy, and especially cause the images to generate artifacts and cause certain harm to the bodies of the children after the excessive injection of the contrast agent.
In the prior art, chinese patent publication No. CN111991020a discloses a contrast agent injection method, apparatus, computer device and storage medium: the method comprises the steps of acquiring basic sign information of a detected person in an infrared scanning, text input or sensor sensing mode; extracting target sign characteristic information from basic sign information of the subject through a pre-trained recurrent neural network model; determining the dosage of the contrast agent to be infused based on the target physical characteristic information, and injecting the contrast agent according to the dosage of the contrast agent.
In the above scheme, although the injection amount of the contrast agent is determined according to the basic sign information of the subject, the injection amount of the contrast agent also needs to be adjusted by matching with parameters such as tube voltage, scanning time and the like of the CT equipment during CT scanning, otherwise, the problem of poor imaging quality is caused, and the diagnosis accuracy is reduced;
thus, there is a need for a personalized injection method for different children at cardiac CTA scan.
Disclosure of Invention
Aiming at the problems of poor imaging effect of the heart CTA of the children, influence on image quality and reduction of diagnosis accuracy in the prior art, the invention provides a heart CTA scanning system of the children and a contrast agent injection method thereof;
a pediatric heart CTA scanning system comprising: CTA device and contrast agent injection device; the contrast agent injection device comprises a main control unit and an input unit; a display unit; the main control unit is respectively connected with a first high-pressure injection pump and a second high-pressure injection pump, a contrast medium needle cylinder filled with contrast medium is arranged on the first high-pressure injection pump, and a saline needle cylinder filled with saline is arranged on the second high-pressure injection pump; the liquid outlet ends of the contrast agent needle cylinder and the saline needle cylinder are respectively connected with the injection tube through a first regulating valve and a second regulating valve; the liquid outlet ends of the contrast agent needle cylinder and the saline needle cylinder are respectively connected with the liquid inlet end of the mixer through a third regulating valve and a fourth regulating valve, and the liquid outlet end of the mixer is connected with the injection tube through a check valve; the first regulating valve, the second regulating valve, the third regulating valve and the fourth regulating valve are respectively connected with the main control unit; the flow rate of the contrast agent or the saline can be controlled by controlling the first regulating valve or the second regulating valve, and the flow rate and the mixing proportion of the contrast agent and the saline mixed solution can be controlled by controlling the third regulating valve and the fourth regulating valve.
Preferably, the method for injecting the contrast agent by using the CTA scanning system comprises the following steps:
s1: setting injection time, including three phases, namely a first phase, injecting contrast agent and injecting for 10 seconds; in the second stage, injecting a mixed solution of contrast agent and saline for 13s; third, saline is injected for 6-10s;
s2: calculating injection flow rate according to the characteristic information of the infant;
s3: the injection flow rate and injection time were fine-tuned according to the parameters of the CTA device.
Preferably, in the step S1, the contrast agent and the saline are mixed according to a ratio of 3:7.
Preferably, in the step S2, the characteristic information includes a weight;
preferably, in the step S2, the flow rate calculating process is as follows:
s21, inputting weight parameters through an input unit;
s22, dividing the infant into corresponding weight ranges according to the weight of the infant, including less than 40kg,
40-60kg greater than 60kg;
s23: calculating the flow rate, namely multiplying the flow rate by the weight of the infant according to the coefficient corresponding to the weight range of the infant, wherein the coefficient is 0.1ml/s/kg when the flow rate is less than 40 kg; when the ratio is within the range of 40-60kg, the coefficient is 0.08ml/s/kg; above 60kg, the coefficient is 0.06ml/s/kg; the maximum flow rate is not more than 5ml/s.
Preferably, the step 3 specifically includes the following steps:
s31: finely adjusting the injection flow rate according to the CTA equipment tube voltage;
s32: fine-tuning injection time according to scan time t of the CTA device, wherein injection time = t+6s,6s is an empirical value, and is time for the contrast agent to reach enhanced peak concentration (threshold value of scan on CAT device) after being injected into the infant; the injection duration of the second and third phases is unchanged during the adjustment.
Preferably, in the step S31, the tube voltage is dynamically increased or decreased by 0.5ml/S for every 10kv of the flow rate.
Compared with the prior art, the invention has the following beneficial effects:
when the CTA scanning system adopts the contrast agent injection method to inject the contrast agent, the dosage of the contrast agent is reduced, artifacts generated by CT images are avoided, good image quality is obtained, meanwhile, the consistency of the images is ensured, and the image quality difference caused by different technicians adopting different experience values is avoided; the heart CTA scanning process of children is standardized and normalized, and the illness state of children is easy to treat.
Drawings
FIG. 1 is a pediatric cardiac CTA scanning system of the invention;
FIG. 2 is a flow chart of a method of contrast injection for a pediatric cardiac CTA scanning system of the invention;
FIG. 3 is a block diagram of the process of adjusting the injection flow rate in the contrast agent injection method of the present invention;
FIG. 4 is a block diagram of the process of adjusting the injection time in the contrast agent injection method of the present invention;
FIG. 5 is a comparative example one of a CTA scan image of a conventional injection method and the present injection method;
FIG. 6 is a comparative example two of a CTA scan image of a conventional injection method and the present injection method;
in the figure: 1. a main control unit; 2. CTA equipment; 3. an input unit; 4. a display unit; 5. a first high pressure syringe pump; 6. a second high pressure syringe pump; 7. a brine syringe; 9. a contrast agent syringe; 10. a first regulating valve; 11. a second regulating valve; 12. a third regulating valve; 13. a fourth regulating valve; 14. a mixer; 15. a check valve; 16. a syringe tube.
Detailed Description
Figures 1-5 of the drawings are incorporated in embodiments of the present invention; the technical scheme in the embodiment of the invention is clearly and completely described:
in one embodiment of the invention, as shown in FIG. 1, a pediatric cardiac CTA scanning system, comprising: CTA device and contrast agent injection device; the contrast agent injection device comprises a main control unit 1, a control unit and a control unit, wherein the main control unit is used for controlling the injection duration and the flow rate of contrast agent mainly according to input parameters; an input unit 3 for inputting basic characteristics of the infant, which may be height, weight, age, sex, etc.; a display unit 4 for displaying various states and parameters during the injection of the contrast agent; the main control unit 1 is respectively connected with a first high-pressure injection pump 5 and a second high-pressure injection pump 6, a contrast agent needle cylinder 9 filled with contrast agent is arranged on the first high-pressure injection pump 5, a saline water needle cylinder 7 filled with saline water is arranged on the second high-pressure injection pump 6, and the injection duration of the contrast agent, the saline water or the mixed solution of the contrast agent and the saline water is controlled by controlling the first high-pressure injection pump 5 and the second high-pressure injection pump 6; the liquid outlet ends of the contrast agent needle cylinder 9 and the saline needle cylinder 7 are respectively connected with an injection tube 16 through a first regulating valve 10 and a second regulating valve 11; the liquid outlet ends of the contrast agent needle cylinder 9 and the saline needle cylinder 7 are respectively connected with the liquid inlet end of the mixer 14 through a regulating valve III 12 and a regulating valve IV 13, and the liquid outlet end of the mixer 14 is connected with the injection tube 16 through a check valve 15; the first regulating valve 10, the second regulating valve 11, the third regulating valve 12 and the fourth regulating valve 13 are respectively connected with the main control unit 1; the flow rate of the contrast agent or the saline can be controlled by controlling the first regulating valve 10 or the second regulating valve 11, and the flow rate and the mixing proportion of the contrast agent and the saline mixture can be controlled by controlling the third regulating valve 12 and the fourth regulating valve 13.
As shown in fig. 2-6, the method for injecting contrast agent by using the CTA scanning system comprises the following steps:
s1: setting injection time, including three phases, namely a first phase, injecting contrast agent and injecting for 10 seconds; in the second stage, injecting a mixed solution of contrast agent and saline according to a ratio of 3:7 for 13s; thirdly, injecting saline for 6-10s;
s2: calculating injection flow rate according to the characteristic information of the infant, wherein the characteristic information comprises weight, and the flow rate calculating process comprises the following steps:
s21, inputting weight parameters through an input unit 3;
s22, dividing the infant into corresponding weight ranges according to the weight of the infant, wherein the weight ranges are smaller than 40kg,40-60kg is larger than 60kg;
s23: calculating the flow rate, namely multiplying the flow rate by the weight of the infant according to the coefficient corresponding to the weight range of the infant, wherein the coefficient is 0.1ml/s/kg when the flow rate is less than 40 kg; when the ratio is within the range of 40-60kg, the coefficient is 0.08ml/s/kg; above 60kg, the coefficient is 0.06ml/s/kg; the maximum flow rate is not more than 5ml/s.
S3: finely adjusting the injection flow rate and the injection time according to the parameters of the CTA equipment;
wherein, include:
s31: the injection flow rate is finely adjusted according to the tube voltage of the CTA equipment, and the tube voltage rises or falls by 0.5ml/s every 10kv flow rate dynamically when the tube voltage is adjusted;
s32: fine-tuning injection time according to scan time t of the CTA device, wherein injection time = t+6s,6s is an empirical value, and is time for the contrast agent to reach enhanced peak concentration (threshold value of scan on CAT device) after being injected into the infant; the injection time length of the second period and the third period is unchanged during adjustment;
feasibility verification of the injection method:
collecting 150 CTA images of infants injected by the method, and scoring the CTA images; the scoring criteria and results are shown in table 1:
TABLE 1CTA image criteria and results
After verification, 90% of images can reach 3 points or more, and 100% of case images can reach 2 points or more, so that a three-stage injection scheme is indicated to be feasible;
compared with the effect of the traditional second-stage injection method:
as shown in fig. 5 and 6, the two different levels of the same infant are compared after the traditional two-stage injection method and the method are adopted respectively; the CTA scan image after the traditional two-stage injection method is adopted in fig. 5a and 6a, and the CTA scan image after the injection method of the invention is adopted in fig. 5b and 6b, so that the hardening ray artifact is serious, the right heart and the room space are affected to be observed, the contrast agent is uniformly mixed by adopting the injection method of the invention, the room space is clearly displayed, and in addition, the contrast agent consumption of the infant is 27ml, compared with the contrast agent consumption of 40ml required by the infant weighing the same as the traditional two-stage injection method, the contrast agent consumption is obviously reduced.
The foregoing description is only a preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to apply equivalents and modifications according to the technical scheme and the modified concept of the present invention within the scope of the present invention.
Claims (8)
1. A pediatric heart CTA scanning system comprising: CTA device and contrast agent injection device; the method is characterized in that: the contrast agent injection device comprises a main control unit and an input unit; a display unit; the main control unit is respectively connected with a first high-pressure injection pump and a second high-pressure injection pump, a contrast medium needle cylinder filled with contrast medium is arranged on the first high-pressure injection pump, and a saline needle cylinder filled with saline is arranged on the second high-pressure injection pump; the liquid outlet ends of the contrast agent needle cylinder and the saline needle cylinder are respectively connected with the injection tube through a first regulating valve and a second regulating valve; the liquid outlet ends of the contrast agent needle cylinder and the saline needle cylinder are respectively connected with the liquid inlet end of the mixer through a third regulating valve and a fourth regulating valve, and the liquid outlet end of the mixer is connected with the injection tube through a check valve; the first regulating valve, the second regulating valve, the third regulating valve and the fourth regulating valve are respectively connected with the main control unit; the flow rate of the contrast agent or the saline can be controlled by controlling the first regulating valve or the second regulating valve, and the flow rate and the mixing proportion of the contrast agent and the saline mixed solution can be controlled by controlling the third regulating valve and the fourth regulating valve.
2. A method of contrast injection for a pediatric cardiac CTA scanning system according to claim 1 wherein: the method comprises the following steps:
s1: setting injection time;
s2: calculating injection flow rate according to the characteristic information of the infant;
s3: the injection flow rate and injection time were fine-tuned according to the parameters of the CTA device.
3. A method of contrast injection for a pediatric cardiac CTA scanning system according to claim 2 wherein: the injection time in the step S1 comprises three periods, namely a first period, a contrast agent injection period and an injection period of 10S; in the second stage, injecting a mixed solution of contrast agent and saline for 13s; and in the third stage, saline is injected for 6-10s.
4. A method of contrast injection for a pediatric cardiac CTA scanning system according to claim 1 wherein: in the step S1, the contrast agent and the saline are mixed according to a ratio of 3:7.
5. A method of contrast injection for a pediatric cardiac CTA scanning system according to claim 1 wherein: in the step S2, the characteristic information includes a body weight.
6. A method of contrast injection for a pediatric cardiac CTA scanning system as defined in claim 5 wherein: in the step S2, the flow rate calculating process is as follows:
s21, inputting weight parameters through an input unit;
s22, dividing the infant into corresponding weight ranges according to the weight of the infant, including less than 40kg,
40-60kg greater than 60kg;
s23: calculating the flow rate, namely multiplying the flow rate by the weight of the infant according to the coefficient corresponding to the weight range of the infant, wherein the coefficient is 0.1ml/s/kg when the flow rate is less than 40 kg; when the ratio is within the range of 40-60kg, the coefficient is 0.08ml/s/kg; above 60kg, the coefficient is 0.06ml/s/kg; the maximum flow rate is not more than 5ml/s.
7. A method of contrast injection for a pediatric cardiac CTA scanning system according to claim 1 wherein: the step 3 specifically comprises the following steps:
s31: finely adjusting the injection flow rate according to the CTA equipment tube voltage;
s32: fine-tuning the injection time according to the scan time t of the CTA device, injection time = t+6s; the injection duration of the second and third phases is unchanged during the adjustment.
8. A method of contrast injection for a pediatric cardiac CTA scanning system as defined in claim 7 wherein: when the injection flow rate is finely adjusted in the step S31, the tube voltage is dynamically increased or decreased by 0.5ml/S every 10kv flow rate.
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