CN116888138A - 放射性药物缀合组合物及其用途 - Google Patents

放射性药物缀合组合物及其用途 Download PDF

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Publication number
CN116888138A
CN116888138A CN202180092527.XA CN202180092527A CN116888138A CN 116888138 A CN116888138 A CN 116888138A CN 202180092527 A CN202180092527 A CN 202180092527A CN 116888138 A CN116888138 A CN 116888138A
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CN
China
Prior art keywords
conjugate
peptide
amino acid
protein
bond
Prior art date
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Pending
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CN202180092527.XA
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English (en)
Chinese (zh)
Inventor
黛博拉·查理奇
刘俊杰
宋肯
阿兰·农科维奇
德雷克·科尔
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Ruize Biological Co
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Ruize Biological Co
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Publication date
Application filed by Ruize Biological Co filed Critical Ruize Biological Co
Publication of CN116888138A publication Critical patent/CN116888138A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202180092527.XA 2020-11-30 2021-11-30 放射性药物缀合组合物及其用途 Pending CN116888138A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063119555P 2020-11-30 2020-11-30
US63/119,555 2020-11-30
PCT/US2021/061186 WO2022115778A1 (en) 2020-11-30 2021-11-30 Radiopharmaceutical conjugate compositions and uses thereof

Publications (1)

Publication Number Publication Date
CN116888138A true CN116888138A (zh) 2023-10-13

Family

ID=81753691

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180092527.XA Pending CN116888138A (zh) 2020-11-30 2021-11-30 放射性药物缀合组合物及其用途

Country Status (5)

Country Link
US (1) US20230158179A1 (https=)
EP (1) EP4251639A1 (https=)
JP (1) JP2023551539A (https=)
CN (1) CN116888138A (https=)
WO (1) WO2022115778A1 (https=)

Cited By (1)

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CN119874832A (zh) * 2025-01-13 2025-04-25 重庆医科大学 一种新型多肽荧光探针的制备方法及应用

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AU2023283882A1 (en) * 2022-06-10 2025-01-30 Peking University Trifunctional compound and use thereof
WO2024041574A1 (en) * 2022-08-24 2024-02-29 Suzhou Transcenta Therapeutics Co., Ltd. Non-invasive methods using anti-cldn18.2 antibody-radionuclide conjugates
CN117645652A (zh) * 2022-09-02 2024-03-05 核欣(苏州)医药科技有限公司 环肽及其制备方法、包括其的复合物、及其用途
PE20251640A1 (es) * 2022-09-07 2025-06-24 3B Pharmaceuticals Gmbh Ligandos de antigeno de membrana especifica de la prostata (psma) y uso de los mismos
WO2024073622A2 (en) * 2022-09-29 2024-04-04 Rayzebio, Inc. Radiopharmaceutical compositions targeting ephrin type-a receptor 2 and uses thereof
JP2025532958A (ja) * 2022-09-29 2025-10-03 ペプチドリーム株式会社 ＥｐｈＡ２結合保留ペプチド及びそれを含む組成物
WO2024183634A1 (en) * 2023-03-09 2024-09-12 Norroy Bioscience Co., Ltd. Radiolabeled antibody conjugates and uses thereof
JPWO2024195709A1 (https=) * 2023-03-17 2024-09-26
EP4692105A1 (en) * 2023-03-27 2026-02-11 Bivision Pharmaceuticals, Inc Cyclic polypeptide compound and use thereof
WO2024198838A1 (zh) * 2023-03-27 2024-10-03 晶核生物医药科技(南京)有限公司 环状多肽类化合物及其应用
KR20260009883A (ko) * 2023-05-24 2026-01-20 베이징 창핑 래보러토리 신규 삼관능 화합물 및 이의 용도
AU2024282578A1 (en) * 2023-05-31 2025-12-04 Full-Life Technologies Uk Limited Radioligands for targeting cell surface receptors and uses thereof
KR20260022328A (ko) * 2023-06-07 2026-02-19 레이즈바이오, 인크. 글리피칸-3을 표적화하는 방사성제약 조성물 및 그의 용도
CN121712788A (zh) * 2023-06-14 2026-03-20 马里亚纳肿瘤学公司 靶向dll3的肽及其构建体
CN121712787A (zh) * 2023-06-14 2026-03-20 马里亚纳肿瘤学公司 靶向dll3的肽及其构建体
KR20260026051A (ko) * 2023-06-14 2026-02-25 마리아나 온콜로지 인크. Dll3 표적화 펩티드 및 이의 구성체
AU2024326078A1 (en) * 2023-08-15 2026-02-19 Novartis Ag Fap targeting cyclic peptides and conjugates thereof
TW202517674A (zh) 2023-10-19 2025-05-01 德商拜耳廠股份有限公司 抗gpc3抗體及其放射性結合物
WO2025117586A1 (en) * 2023-11-27 2025-06-05 Mariana Oncology Inc. Dll3 targeting peptides and constructs thereof
WO2025137443A1 (en) 2023-12-22 2025-06-26 Rayzebio, Inc. Radiopharmaceutical compositions targeting somatostatin receptors and uses thereof
WO2025179168A1 (en) * 2024-02-22 2025-08-28 Mariana Oncology Inc. Synthesis of dll3-binding peptides
CN119119174B (zh) * 2024-09-12 2025-08-08 重庆医科大学附属第二医院 一种靶向caix和fap的化合物、其核素标记物、制法和应用

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US6017512A (en) 1992-06-23 2000-01-25 Diatide, Inc. Radiolabeled peptides
US5716596A (en) * 1992-06-23 1998-02-10 Diatide, Inc. Radioactively labeled somatostatin-derived peptides for imaging and therapeutic uses
PL3152226T3 (pl) 2014-06-06 2019-10-31 Univ Muenchen Tech Modyfikowane cyklopentapeptydy i ich zastosowania
US10421783B2 (en) * 2016-02-19 2019-09-24 The Curators Of The University Of Missouri Prostate-specific membrane antigen (PSMA) targeting peptides
AU2017281940C1 (en) 2016-06-24 2024-11-07 University Of Iowa Research Foundation Compositions and methods of treating melanoma
WO2020097531A1 (en) * 2018-11-08 2020-05-14 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
JP7801207B2 (ja) * 2019-07-08 2026-01-16 ３ベー ファーマシューティカルズ ゲーエムベーハー 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用
FI3997103T3 (fi) * 2019-07-08 2025-02-03 3B Pharmaceuticals Gmbh Fibroblastien aktivaatioproteiinin ligandia käsittäviä yhdisteitä ja niiden käyttö

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119874832A (zh) * 2025-01-13 2025-04-25 重庆医科大学 一种新型多肽荧光探针的制备方法及应用

Also Published As

Publication number Publication date
JP2023551539A (ja) 2023-12-08
US20230158179A1 (en) 2023-05-25
WO2022115778A1 (en) 2022-06-02
EP4251639A1 (en) 2023-10-04

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